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Transcranial alternating current

X Moisset, J-P Lefaucheur
The use of medications in chronic neuropathic pain may be limited with regard to efficacy and tolerance. Therefore, non-pharmacological approaches, using electrical stimulation of the cortex has been proposed as an alternative. First, in the early nineties, surgically-implanted epidural motor cortex stimulation (EMCS) was proven to be effective to relieve refractory neuropathic pain. Later, non-invasive stimulation techniques were found to produce similar analgesic effects, at least by means of repetitive transcranial magnetic stimulation (rTMS) targeting the primary motor cortex (M1)...
October 12, 2018: Revue Neurologique
B Chi, B Chau, E Yeo, P Ta
BACKGROUND: Treatment of spinal cord injury (SCI)-associated neuropathic pain is challenging, with limited efficacy and no definitive options, and SCI patients often show resistance to pharmacologic treatment. Virtual reality (VR) therapy is a non-invasive, non-pharmacologic alternative with minimal adverse effects. OBJECTIVE: To investigate the effect of VR therapy on SCI-associated neuropathic pain in a systematic review. METHODS: Articles needed to 1) be written in English; 2) include adult subjects, with at least half the study population with a SCI diagnosis; 3) involve any form of VR therapy; and 4) assess neuropathic pain by quantitative outcome measures...
October 9, 2018: Annals of Physical and Rehabilitation Medicine
Eduardo de Souza Nicolau, Kevin Augusto Farias de Alvarenga, Helia Tenza-Ferrer, Matheus Carvalho Alves Nogueira, Fernanda Donizete Rezende, Nycolle Ferreira Nicolau, Mélcar Collodetti, Débora Marques de Miranda, Luiz Alexandre Viana Magno, Marco Aurélio Romano-Silva
Transcranial direct current stimulation (tDCS) is a non-invasive neuromodulation technique proposed as an alternative or complementary treatment for several neuropsychiatric diseases. The biological effects of tDCS are not fully understood, which is in part explained due to the difficulty in obtaining human brain tissue. This protocol describes a tDCS mouse model that uses a chronically implanted electrode allowing the study of the long-lasting biological effects of tDCS. In this experimental model, tDCS changes the cortical gene expression and offers a prominent contribution to the understanding of the rationale for its therapeutic use...
September 23, 2018: Journal of Visualized Experiments: JoVE
A K Martin, J Huang, A Hunold, M Meinzer
Theories of right temporoparietal junction (rTPJ) function in social cognition include self-other distinction, self-inhibition, or embodied rotation, whereas the dorsomedial prefrontal cortex (dmPFC) is associated with integrating social information. However, no study has provided causal evidence for dissociable roles of the rTPJ and dmPFC in social cognition. A total of 52 healthy young adults were stratified to receive either dmPFC or rTPJ anodal high-definition transcranial direct current stimulation (HD-tDCS) in a sham-controlled, double-blinded, repeated measures design...
October 1, 2018: Cerebral Cortex
Gabriele Fusco, Michele Scandola, Matteo Feurra, Enea F Pavone, Simone Rossi, Salvatore M Aglioti
Cognitive control during conflict monitoring, error processing, and post-error adjustment appear to be associated with the occurrence of midfrontal theta (MFϴ). While this association is supported by correlational EEG studies, much less is known about the possible causal link between MFϴ and error and conflict processing. In the present study, we aimed to explore the role of band-specific effects in modulating the error system during a conflict resolution. In turn, we delivered transcranial alternating current stimulation (tACS) at different frequency bands (delta δ, theta θ, alpha α, beta β, gamma γ) and sham stimulation over the medial frontal cortex (MFC) in 36 healthy participants performing a modified version of the Flanker task...
September 30, 2018: European Journal of Neuroscience
Sangtae Ahn, Julianna H Prim, Morgan L Alexander, Karen L McCulloch, Flavio Fröhlich
Chronic pain is associated with maladaptive reorganization of the central nervous system. Recent studies have suggested that disorganization of large-scale electrical brain activity patterns such as neuronal network oscillations in the thalamo-cortical system plays a key role in the pathophysiology of chronic pain. Yet, little is known about if and how such network pathologies can be targeted with non-invasive brain stimulation as a non-pharmacological treatment option. We hypothesized that alpha oscillations, a prominent thalamo-cortical activity pattern in the human brain, are impaired in chronic pain and can be modulated with transcranial alternating current stimulation (tACS)...
September 27, 2018: Journal of Pain: Official Journal of the American Pain Society
Hisato Sugata, Kazuhiro Yagi, Shogo Yazawa, Yasunori Nagase, Kazuhito Tsuruta, Takashi Ikeda, Kojiro Matsushita, Masayuki Hara, Kenji Kawakami, Keisuke Kawakami
Motor function can be modulated by transcranial alternating current stimulation (tACS) in alpha, beta, and high-gamma frequencies. However, few studies have investigated tACS-induced behavioral changes in combination with endogenous oscillatory neural activity in detail. Herein, we investigated the effect of tACS on motor learning capacity and endogenous oscillatory neural activity. Fifty-two healthy volunteers were randomly assigned to four stimulation groups (10 Hz, 20 Hz, 70 Hz, or sham) and performed a visually cued button press motor learning task before and after tACS, which was delivered at the left primary motor area...
November 1, 2018: Neuroscience
Cristina Ottaviani, Francesco Mancini, Samantha Provenzano, Alberto Collazzoni, Francesca D'Olimpio
Previous studies empirically support the existence of a distinctive association between deontological (but not altruistic) guilt and both disgust and obsessive-compulsive (OC) symptoms. Given that the neural substrate underlying deontological guilt comprises brain regions strictly implicated in the emotion of disgust (i.e. the insula), the present study aimed to test the hypothesis that indirect stimulation of the insula via transcranial direct current stimulation (tDCS) would enhance disgust and morality in the deontological domain...
October 2018: Neuropsychologia
Jim D Herring, Sophie Esterer, Tom R Marshall, Ole Jensen, Til O Bergmann
Low frequency oscillations such as alpha (8-12 Hz) are hypothesized to rhythmically gate sensory processing, reflected by 40-100 Hz gamma band activity, via the mechanism of pulsed inhibition. We applied transcranial alternating current stimulation (TACS) at individual alpha frequency (IAF) and flanking frequencies (IAF-4 Hz, IAF+4 Hz) to the occipital cortex of healthy human volunteers during concurrent magnetoencephalography (MEG), while participants performed a visual detection task inducing strong gamma-band responses...
September 19, 2018: NeuroImage
Rahul Venugopal, Arun Sasidharan, Vrinda Marigowda, Gulshan Kumar, Ajay Kumar Nair, Sumit Sharma, Chetan S Mukundan, Bindu M Kutty
OBJECTIVE: Conventional polysomnographic recordings reflect brain dynamics associated with sleep architecture. We hypothesized that noninvasive tools like transcranial alternating current stimulation (tACS) and acoustic stimulation (for generating event related potentials [ERPs]) would help to predict sleep stability and provide a window to actively assess brain activity during sleep. MATERIALS AND METHODS: Twelve healthy male volunteers participated in the multiple whole-night polysomnography (PSG) recording protocol...
September 20, 2018: Neuromodulation: Journal of the International Neuromodulation Society
Nora Behler, Bianka Leitner, Eva Mezger, Elif Weidinger, Richard Musil, Bernhard Blum, Beatrice Kirsch, Linda Wulf, Lisa Löhrs, Christine Winter, Frank Padberg, Ulrich Palm
Introduction : Current pathophysiological hypotheses of Gilles de la Tourette Syndrome (GTS) refer to temporally abnormal neuronal activation in cortico-striato-thalamo-cortical (CSTC) networks. Modifying cortical activity by non-invasive brain-stimulation appears to be a new treatment option in GTS. Background : Previous studies suggested therapeutic effects of cathodal transcranial direct current stimulation (tDCS) to pre-supplementary motor areas (SMA), however, treatment modalities concerning electrode placement, current intensity and stimulation-rate have not been systematically explored...
2018: Frontiers in Behavioral Neuroscience
Jana Klaus, Dennis J L G Schutter
Previous language production studies targeting the inferior frontal and superior temporal gyrus using anodal tDCS have provided mixed results. Part of this heterogeneity may be explained by limited target region focality of conventionally used electrode montages. We examined the focality of conventionally and alternative electrode montages. Electrical field distributions of anodal tDCS targeting IFG and pSTG were simulated in conventional setups (anodal electrode over left IFG/pSTG, reference electrode over right supraorbital region) and an alternative electrode montage in four different brains...
2018: PloS One
Andrea Guerra, Matteo Bologna, Giulia Paparella, Antonio Suppa, Donato Colella, Vincenzo Di Lazzaro, Peter Brown, Alfredo Berardelli
Transcranial alternating current stimulation (tACS) is a noninvasive neurophysiological technique that can entrain brain oscillations. Only few studies have investigated the effects of tACS on voluntary movements. We aimed to verify whether tACS, delivered over M1 at beta and gamma frequencies, has any effect on repetitive finger tapping as assessed by means of kinematic analysis. Eighteen healthy subjects were enrolled. Objective measurements of repetitive finger tapping were obtained by using a motion analysis system...
2018: Neural Plasticity
Alberto Herrero Babiloni, Samuel Guay, Donald R Nixdorf, Louis de Beaumont, Gilles Lavigne
Background: Transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) are non-invasive brain stimulation techniques that are being explored as therapeutic alternatives for the management of various chronic pain conditions. Objective: The primary objective of this systematic review is to assess the efficacy of TMS and tDCS in reducing clinical pain intensity in chronic orofacial pain (OFP) disorders. The secondary objectives are to describe adverse effects, duration of relief, and TMS/tDCS methodologies used in chronic OFP disorders...
2018: Journal of Pain Research
Koji Ishikuro, Nobuhiro Dougu, Takamasa Nukui, Mamoru Yamamoto, Yuji Nakatsuji, Satoshi Kuroda, Isao Matsushita, Hiroshi Nishimaru, Mariana F P Araujo, Hisao Nishijo
Parkinson's disease (PD) is a neurodegenerative disorder with motor and non-motor symptoms due to degeneration of dopaminergic neurons. The current pharmacological treatments induce complications associated with long-term use. However, current stimulation techniques for PD treatment, such as deep brain stimulation (DBS), are too invasive. In this context, non-invasive brain stimulation including transcranial direct current stimulation (tDCS) may be a safe and effective alternative treatment for PD. We previously reported that anodal tDCS over the frontal polar area (FPA) improved motor functions in heathy subjects...
2018: Frontiers in Aging Neuroscience
Florian H Kasten, Burkhard Maess, Christoph S Herrmann
Non-invasive approaches to modulate oscillatory activity in the brain are increasingly popular in the scientific community. Transcranial alternating current stimulation (tACS) has been shown to modulate neural oscillations in a frequency-specific manner. However, due to a massive stimulation artifact at the targeted frequency, little is known about effects of tACS during stimulation. It remains unclear how the continuous application of tACS affects event-related oscillations during cognitive tasks. Depending on whether tACS influences pre- or post-stimulus oscillations, or both, the endogenous, event-related oscillatory dynamics could be pushed in various directions or not at all...
May 2018: ENeuro
Eugen Kvašňák, Richard Rokyta
Treatment of pain is one of the most important aims of medicine. Over the past several decades, invasive, semi-invasive and non-invasive brain stimulation methods have been tested and implemented for modulation of the pain. In this review we bring the overview of those methods including stimulation of both the deep brain structures utilizing invasive and semi-invasive techniques and brain cortex stimulated by non-invasive transcranial magnetic and electrical techniques. The potentially beneficial method which could modulate the pain by stimulating the deep brain with the interferential transcranial alternating current are discussed as well...
July 31, 2018: General Physiology and Biophysics
Jamila Andoh, Reiko Matsushita, Robert J Zatorre
Non-invasive brain stimulation (NIBS) has been widely used as a research tool to modulate cortical excitability of motor as well as non-motor areas, including auditory or language-related areas. NIBS, especially transcranial magnetic stimulation (TMS) and transcranial direct current stimulation, have also been used in clinical settings, with however variable therapeutic outcome, highlighting the need to better understand the mechanisms underlying NIBS techniques. TMS was initially used to address causality between specific brain areas and related behavior, such as language production, providing non-invasive alternatives to lesion studies...
2018: Frontiers in Neuroscience
Nicholas Ketz, Aaron P Jones, Natalie B Bryant, Vincent P Clark, Praveen K Pilly
Benefits in long-term memory retention and generalization have been shown to be related to sleep-dependent processes, which correlate with neural oscillations as measured by changes in electric potential. The specificity and causal role of these oscillations, however, are still poorly understood. Here, we investigated the potential for augmenting endogenous slow-wave (SW) oscillations in humans with closed-loop transcranial alternating current stimulation (tACS) with an aim toward enhancing the consolidation of recent experiences into long-term memory...
August 15, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
Shota Miyaguchi, Naofumi Otsuru, Sho Kojima, Kei Saito, Yasuto Inukai, Mitsuhiro Masaki, Hideaki Onishi
Transcranial alternating current stimulation (tACS) can be used to modulate oscillatory brain activity. In this study, we investigated whether tACS applied over the primary motor cortex (M1) and cerebellar cortex region improved motor performance. We applied tACS (1.0 mA) to 20 healthy adults while they performed an isometric force task with some visuomotor control using their right index finger. Gamma (70 Hz) oscillations in the Experiment 1 or beta (20 Hz) oscillations in the Experiment 2 were applied for 30 s over the left M1, right cerebellar hemisphere or both regions ("M1-Cerebellum"), and errors performing the task were compared...
2018: Frontiers in Behavioral Neuroscience
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