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Transcranial alternating current

Koji Ishikuro, Nobuhiro Dougu, Takamasa Nukui, Mamoru Yamamoto, Yuji Nakatsuji, Satoshi Kuroda, Isao Matsushita, Hiroshi Nishimaru, Mariana F P Araujo, Hisao Nishijo
Parkinson's disease (PD) is a neurodegenerative disorder with motor and non-motor symptoms due to degeneration of dopaminergic neurons. The current pharmacological treatments induce complications associated with long-term use. However, current stimulation techniques for PD treatment, such as deep brain stimulation (DBS), are too invasive. In this context, non-invasive brain stimulation including transcranial direct current stimulation (tDCS) may be a safe and effective alternative treatment for PD. We previously reported that anodal tDCS over the frontal polar area (FPA) improved motor functions in heathy subjects...
2018: Frontiers in Aging Neuroscience
Florian H Kasten, Burkhard Maess, Christoph S Herrmann
Non-invasive approaches to modulate oscillatory activity in the brain are increasingly popular in the scientific community. Transcranial alternating current stimulation (tACS) has been shown to modulate neural oscillations in a frequency-specific manner. However, due to a massive stimulation artifact at the targeted frequency, little is known about effects of tACS during stimulation. It remains unclear how the continuous application of tACS affects event-related oscillations during cognitive tasks. Depending on whether tACS influences pre- or post-stimulus oscillations, or both, the endogenous, event-related oscillatory dynamics could be pushed in various directions or not at all...
May 2018: ENeuro
Eugen Kvašňák, Richard Rokyta
Treatment of pain is one of the most important aims of medicine. Over the past several decades, invasive, semi-invasive and non-invasive brain stimulation methods have been tested and implemented for modulation of the pain. In this review we bring the overview of those methods including stimulation of both the deep brain structures utilizing invasive and semi-invasive techniques and brain cortex stimulated by non-invasive transcranial magnetic and electrical techniques. The potentially beneficial method which could modulate the pain by stimulating the deep brain with the interferential transcranial alternating current are discussed as well...
July 31, 2018: General Physiology and Biophysics
Jamila Andoh, Reiko Matsushita, Robert J Zatorre
Non-invasive brain stimulation (NIBS) has been widely used as a research tool to modulate cortical excitability of motor as well as non-motor areas, including auditory or language-related areas. NIBS, especially transcranial magnetic stimulation (TMS) and transcranial direct current stimulation, have also been used in clinical settings, with however variable therapeutic outcome, highlighting the need to better understand the mechanisms underlying NIBS techniques. TMS was initially used to address causality between specific brain areas and related behavior, such as language production, providing non-invasive alternatives to lesion studies...
2018: Frontiers in Neuroscience
Nicholas Ketz, Aaron Jones, Natalie Bryant, Vincent P Clark, Praveen K Pilly
Benefits in long-term memory retention and generalization have been shown to be related to sleep-dependent processes, which correlate with neural oscillations as measured by changes in electric potential. The specificity and causal role of these oscillations, however, are still poorly understood. Here, we investigated the potential for augmenting endogenous Slow-Wave (SW) oscillations in humans with closed-loop transcranial alternating current stimulation (tACS) with an aim towards enhancing the consolidation of recent experiences into long-term memory...
July 23, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
Shota Miyaguchi, Naofumi Otsuru, Sho Kojima, Kei Saito, Yasuto Inukai, Mitsuhiro Masaki, Hideaki Onishi
Transcranial alternating current stimulation (tACS) can be used to modulate oscillatory brain activity. In this study, we investigated whether tACS applied over the primary motor cortex (M1) and cerebellar cortex region improved motor performance. We applied tACS (1.0 mA) to 20 healthy adults while they performed an isometric force task with some visuomotor control using their right index finger. Gamma (70 Hz) oscillations in the Experiment 1 or beta (20 Hz) oscillations in the Experiment 2 were applied for 30 s over the left M1, right cerebellar hemisphere or both regions ("M1-Cerebellum"), and errors performing the task were compared...
2018: Frontiers in Behavioral Neuroscience
Vanteemar S Sreeraj, Venkataram Shivakumar, Selvaraj Sowmya, Anushree Bose, Hema Nawani, Janardhanan C Narayanaswamy, Ganesan Venkatasubramanian
Transcranial alternating current stimulation (tACS), a noninvasive brain stimulation technique that uses low-intensity alternating current, has been postulated to be a potential therapeutic option in treating the cognitive deficits in schizophrenia. Transcranial alternating current stimulation synchronizes the neural oscillations to the applied stimulation frequency in the stimulated cortical regions. In this report, we have reviewed the literature pertinent to the clinical application of tACS in psychiatric disorders; in addition, we have described the clinical use of online theta tACS in a schizophrenia patient with cognitive deficits...
July 17, 2018: Journal of ECT
Martine R van Schouwenburg, Lynn K A Sörensen, Raza de Klerk, Leon C Reteig, Heleen A Slagter
In a previous study using transcranial alternating current stimulation (tACS), we found preliminary evidence that phase coherence in the alpha band (8-12 Hz) within the fronto-parietal network may critically support top-down control of spatial attention (van Schouwenburg et al., 2017). Specifically, synchronous alpha-band stimulation over the right frontal and parietal cortex (0° relative phase) was associated with changes in performance and fronto-parietal coherence during a spatial attention task as compared to sham stimulation...
2018: Frontiers in Neuroscience
Daniel L Madden, Martin V Sale, Gail A Robinson
INTRODUCTION: Normal aging is associated with deficits in various aspects of spoken language production, including idea generation and selection, and involves activity in frontal brain areas including left inferior frontal cortex (LIFG). These conceptual preparation processes, largely involving executive control, precede formulation and articulation stages and are critical for language production. Noninvasive brain stimulation (e.g., transcranial direct current stimulation, tDCS) has proven beneficial for age-related fluency and naming deficits, but this has not been extended to conceptual preparation mechanisms...
July 17, 2018: Journal of Clinical and Experimental Neuropsychology
Thomas Reed, Roi Cohen Kadosh
In this review, we describe transcranial electrical stimulation (tES) techniques currently being used in neuroscientific research, including transcranial direct current (tDCS), alternating current (tACS) and random noise (tRNS) stimulation techniques. We explain how these techniques are used and summarise the proposed mechanisms of action for each technique. We continue by describing how each method has been used to alter endogenous neuronal oscillations and connectivity between brain regions, and we conclude by highlighting the varying effects of stimulation and discussing the future direction of these stimulation techniques in research...
July 13, 2018: Journal of Inherited Metabolic Disease
M Wischnewski, M Engelhardt, M A Salehinejad, D J L G Schutter, M-F Kuo, M A Nitsche
Transcranial alternating current stimulation (tACS) has been shown to modulate neural oscillations and excitability levels in the primary motor cortex (M1). These effects can last for more than an hour and an involvement of N-methyl-d-aspartate receptor (NMDAR) mediated synaptic plasticity has been suggested. However, to date the cortical mechanisms underlying tACS after-effects have not been explored. Here, we applied 20 Hz beta tACS to M1 while participants received either the NMDAR antagonist dextromethorphan or a placebo and the effects on cortical beta oscillations and excitability were explored...
July 10, 2018: Cerebral Cortex
Tomer Fekete, Andrey R Nikolaev, Floris De Knijf, Aleksandra Zharikova, Cees van Leeuwen
Transcranial alternating-current stimulation (tACS) for entraining alpha activity holds potential for influencing mental function, both in laboratory and clinical settings. While initial results of alpha entrainment are promising, questions remain regarding its translational potential-namely if tACS alpha entrainment is sufficiently robust to context and to what extent it can be upscaled to multi-electrode arrangements needed to direct currents into precise brain loci. We set out to explore these questions by administering alternating current through a multi-electrode montage (mtACS), while varying background task...
2018: Frontiers in Neuroscience
Heiko I Stecher, Christoph S Herrmann
Transcranial alternating current stimulation (tACS) has found widespread use as a basic tool in the exploration of the role of brain oscillations. Many studies have shown that frequency-specific tACS is able to not only alter cognitive processes during stimulation, but also cause specific physiological aftereffects visible in the electroencephalogram (EEG). The relationship between the emergence of these aftereffects and the necessary duration of stimulation is inconclusive. Our goal in this study was to narrow down the crucial length of tACS-blocks, by which aftereffects can be elicited...
2018: Frontiers in Psychology
Esin Turkakin, Seda Akbıyık, Bihter Akyol, Ceren Gürdere, Yusuf Ö Çakmak, Fuat Balcı
One of the critical factors that guide choice behavior is the prior bias of the decision-maker with respect to different options, namely, the relative readiness by which the decision-maker opts for a specific choice. Although previous neuroimaging work has shown decision bias related activity in the orbitofrontal cortex, intraparietal sulcus (IPS) and dorsolateral prefrontal cortex, in a recent work by Javadi et al. (2015), primary motor cortex was also implicated. By applying transcranial direct current stimulation (tDCS), they have revealed a causal role of the primary motor cortex excitability in the induction of response time (RT) differences and decision bias in the form of choice probability...
2018: Frontiers in Neuroscience
Chiahao Lu, Sommer L Amundsen Huffmaster, Paul J Tuite, Colum D MacKinnon
OBJECTIVE: We investigated if anodal transcranial direct current stimulation (A-tDCS), applied over the supplementary motor areas (SMAs), could improve gait initiation in Parkinson's disease (PD) with freezing of gait (FOG). METHODS: In this double-blinded cross-over pilot study, ten PD with FOG underwent two stimulation sessions: A-tDCS (1 mA, 10 min) and sham stimulation. Eight blocks of gait initiation were collected per session: (1) pre-tDCS, with acoustic cueing; (2) pre-tDCS, self-initiated (no cue); and (3-8) post-tDCS, self-initiated...
June 28, 2018: Journal of Neurology
Shane Fresnoza, Monica Christova, Theresa Feil, Eugen Gallasch, Christof Körner, Ulrike Zimmer, Anja Ischebeck
Transcranial alternating current stimulation (tACS) can modulate brain oscillations, cortical excitability and behaviour. In aging, the decrease in EEG alpha activity (8-12 Hz) in the parieto-occipital and mu rhythm in the motor cortex are correlated with the decline in cognitive and motor functions, respectively. Increasing alpha activity using tACS might therefore improve cognitive and motor function in the elderly. The present study explored the influence of tACS on cortical excitability in young and old healthy adults...
June 26, 2018: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
Sanne Koops, Jan Dirk Blom, Ouarda Bouachmir, Margot I Slot, Bas Neggers, Iris E Sommer
OBJECTIVE: Transcranial direct current stimulation (tDCS) could be a treatment option for medication-resistant auditory hallucinations (AH), but so far results have been inconclusive, and large sample trials have been missing. This study used tDCS as a treatment method for these hallucinations in a double-blind, placebo-controlled study with a relatively large sample size. METHODS: Fifty-four patients of several diagnostic categories with medication-resistant AH were randomized and treated during 10 sessions of 20 min each, with either 2 mA tDCS or placebo, administered on five consecutive days (i...
June 19, 2018: Schizophrenia Research
Samar S Ayache, Moussa A Chalah
Multiple sclerosis (MS) is a neurological disease of the central nervous system characterized by inflammation, demyelination and neurodegeneration. Throughout the disease process, patients may complain of a panel of sensory, motor, cognitive and behavioral symptoms. Fatigue is a debilitating manifestation of central nervous system diseases with physical, cognitive and psychosocial dimensions. In MS, fatigue could be very frequent concerning up to 90% of patients and may have a drastic impact on their quality of life...
June 15, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
Chun-Hung Chang, Hsien-Yuan Lane, Chieh-Hsin Lin
Brain stimulation techniques can modulate cognitive functions in many neuropsychiatric diseases. Pilot studies have shown promising effects of brain stimulations on Alzheimer's disease (AD). Brain stimulations can be categorized into non-invasive brain stimulation (NIBS) and invasive brain stimulation (IBS). IBS includes deep brain stimulation (DBS), and invasive vagus nerve stimulation (VNS), whereas NIBS includes transcranial magnetic stimulation (TMS), transcranial direct current stimulation (tDCS), transcranial alternating current stimulation (tACS), electroconvulsive treatment (ECT), magnetic seizure therapy (MST), cranial electrostimulation (CES), and non-invasive VNS...
2018: Frontiers in Psychiatry
Jacquelyn MacDonell, Niravkumar Patel, Gregory Fischer, E Clif Burdette, Jiang Qian, Vaibhav Chumbalkar, Goutam Ghoshal, Tamas Heffter, Emery Williams, Matthew Gounis, Robert King, Juliette Thibodeau, Gene Bogdanov, Olivia W Brooks, Erin Langan, Roy Hwang, Julie G Pilitsis
BACKGROUND: Ablative lesions are current treatments for epilepsy and brain tumors. Interstitial magnetic resonance (MR) guided focused ultrasound (iMRgFUS) may be an alternate ablation technique which limits thermal tissue charring as compared to laser therapy (LITT) and can produce larger ablation patterns nearer the surface than transcranial MR guided focused ultrasound (tcMRgFUS). OBJECTIVE: To describe our experience with interstitial focused ultrasound (iFUS) ablations in swine, using MR-guided robotically assisted (MRgRA) delivery...
June 14, 2018: Neurosurgery
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