Yingchun Yang, Rong Yang, Fangqing Deng, Luqiu Yang, Guanghao Yang, Yanyan Liu, Qing Tian, Zixi Wang, Aipeng Li, Li Shang, Genyang Cheng, Lianbing Zhang
An improved innate immunity will respond quickly to pathogens and initiate efficient adaptive immune responses. However, up to now, there have been limited clinical ways for effective and rapid consolidation of innate immunity. Here, we report that cutaneous irradiation with blue light of 450 nm rapidly stimulates the innate immunity through cell endogenous reactive oxygen species (ROS) regulation in a noninvasive way. The iron porphyrin-containing proteins, mitochondrial cytochrome c (Cyt-c), and cytochrome p450 (CYP450) can be mobilized by blue light, which boosts electron transport and ROS production in epidermal and dermal tissues...
April 12, 2024: ACS Pharmacology & Translational Science