keyword
https://read.qxmd.com/read/38498074/promoting-effect-of-tivc-mxene-on-cathodic-electrogenerated-chemiluminescence-of-ru-bpy-3-2-and-its-application-in-the-sensitive-detection-of-sulfite
#1
JOURNAL ARTICLE
Haifeng Yao, Xinyi Wang, Yongping Dong, Mingfu Ye
The enhanced cathodic ECL of Ru(bpy)3 2+ at a bimetallic element MXenes (TiVC MXene) modified electrode in neutral aqueous condition is reported. TiVC MXene significantly catalyzed the oxygen reduction reaction (ORR) as well as the electrochemical reduction of Ru(bpy)3 2+ to produce reactive oxygen species and Ru(bpy)3 + . The obtained hydroxyl radical (OH∙) not only oxidized Ru(bpy)3 + to generate Ru(bpy)3 2+* and emit light through coreactant pathway, but also oxidized Ru(bpy)3 2+ to Ru(bpy)3 3+ , which caused an annihilation ECL reaction...
March 18, 2024: Mikrochimica Acta
https://read.qxmd.com/read/38497930/er-stress-promotes-mitochondrial-calcium-overload-and-activates-the-ros-nlrp3-axis-to-mediate-fatty-liver-ischemic-injury
#2
JOURNAL ARTICLE
Fei Li, Zhu Guan, Yiyun Gao, Yan Bai, Xinyu Zhan, Xingyue Ji, Jian Xu, Haoming Zhou, Zhuqing Rao
BACKGROUND: Fatty livers are widely accepted as marginal donors for liver transplantation but are more susceptible to liver ischemia and reperfusion (IR) injury. Increased macrophage-related inflammation plays an important role in the aggravation of fatty liver IR injury. Here, we investigate the precise mechanism by which endoplasmic reticulum (ER) stress activates macrophage NOD-like receptor thermal protein domain-associated protein 3 (NLRP3) signaling by regulating mitochondrial calcium overload in fatty liver IR...
April 1, 2024: Hepatology Communications
https://read.qxmd.com/read/38497734/oxidative-stress-endothelial-dysfunction-and-n-acetylcysteine-in-type-2-diabetes-mellitus
#3
JOURNAL ARTICLE
Xin Li, Junyong Zou, Aiping Lin, Jingshu Chi, Hong Hao, Hong Chen, Zhenguo Liu
Cardiovascular diseases (CVDs) remain the leading cause of morbidity and mortality globally. Endothelial dysfunction is closely associated with the development and progression of CVDs. Patients with diabetes mellitus (DM) especially type-2 DM exhibit a significant endothelial cell dysfunction with substantially increased risk for CVDs. Excessive reactive oxygen species (ROS) and oxidative stress are important contributing factors to endothelial cell dysfunction and subsequent CVDs. ROS production is significantly increased in DM and is critically involved in the development of endothelial dysfunction in diabetic patients...
March 18, 2024: Antioxidants & Redox Signaling
https://read.qxmd.com/read/38497722/assessment-of-small-vessel-function-using-7t-mri-in-patients-with-sporadic-cerebral-small-vessel-disease-the-zoom-svds-study
#4
JOURNAL ARTICLE
Hilde Van Den Brink, Stanley Pham, Jeroen C Siero, Tine Arts, Laurien Onkenhout, Hugo Kuijf, Jeroen Hendrikse, Joanna M Wardlaw, Martin Dichgans, Jaco J Zwanenburg, Geert Jan Biessels
BACKGROUND AND OBJECTIVES: Cerebral small vessel disease (cSVD) is a major cause of stroke and dementia, but little is known about disease mechanisms at the level of the small vessels. 7T-MRI allows assessing small vessel function in vivo in different vessel populations. We hypothesized that multiple aspects of small vessel function are altered in patients with cSVD and that these abnormalities relate to disease burden. METHODS: Patients and controls participated in a prospective observational cohort study, the ZOOM@SVDs study...
March 12, 2024: Neurology
https://read.qxmd.com/read/38497587/injectable-nanocomposite-hydrogels-with-strong-antibacterial-osteoinductive-and-ros-scavenging-capabilities-for-periodontitis-treatment
#5
JOURNAL ARTICLE
Yue Yu, Ziying You, Xin Li, Feng Lou, Ding Xiong, Ling Ye, Zhenming Wang
Injectable antibacterial and osteoinductive hydrogels have received considerable attention for promoting bone regeneration owing to their versatile functionalities. However, a current hydrogel with antibacterial, osteoinductive, and antioxidant properties by a facile method for periodontitis treatment is still missing. To overcome this issue, we designed an injectable hydrogel system (GPM) composed of gelatin, Ti3 C2 T x MXene nanosheets, and poly-l-lysine using a simple enzymatic cross-linking technique. Physicochemical characterization demonstrated that the GPM hydrogel matrix exhibited excellent stability, moderate tissue adhesion ability, and good mechanical behavior...
March 18, 2024: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/38497434/enhanced-ros-scavenging-and-tissue-adhesive-abilities-in-injectable-hydrogels-by-protein-modification-with-oligoethyleneimine
#6
JOURNAL ARTICLE
Debabrata Palai, Miho Ohta, Iga Cetnar, Tetsushi Taguchi, Akihiro Nishiguchi
Postsurgical treatment comprehensively benefits from the application of tissue-adhesive injectable hydrogels, which reduce postoperative complications by promoting wound closure and tissue regeneration. Although various hydrogels have been employed as clinical tissue adhesives, many exhibit deficiencies in adhesive strength under wet conditions or in immunomodulatory functions. Herein, we report the development of reactive oxygen species (ROS) scavenging and tissue-adhesive injectable hydrogels composed of polyamine-modified gelatin crosslinked with the 4-arm poly (ethylene glycol) crosslinker...
March 18, 2024: Biomaterials Science
https://read.qxmd.com/read/38497341/external-stimuli-responsive-strategies-for-surface-modification-of-orthopedic-implants-killing-bacteria-and-enhancing-osteogenesis
#7
REVIEW
Xujie Liu, Zhenzhen Feng, Zhili Ran, Yaoxun Zeng, Guining Cao, Xinyi Li, Huiling Ye, Meijing Wang, Wanting Liang, Yan He
Bacterial infection and insufficient osteogenic activity are the main causes of orthopedic implant failure. Conventional surface modification methods are difficult to meet the requirements for long-term implant placement. In order to better regulate the function of implant surfaces, especially to improve both the antibacterial and osteogenic activity, external stimuli-responsive (ESR) strategies have been employed for the surface modification of orthopedic implants. External stimuli act as "smart switches" to regulate the surface interactions with bacteria and cells...
March 18, 2024: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/38497338/therapeutic-strategies-to-modulate-gut-microbial-health-approaches-for-sarcopenia-management
#8
REVIEW
Shreya Das, B Preethi, Sapana Kushwaha, Richa Shrivastava
Sarcopenia is a progressive and generalized loss of skeletal muscle and functions associated with ageing with currently no definitive treatment. Alterations in gut microbial composition have emerged as a significant contributor to the pathophysiology of multiple diseases. Recently, its association with muscle health has pointed to its potential role in mediating sarcopenia. The current review focuses on the association of gut microbiota and mediators of muscle health, connecting the dots between the influence of gut microbiota and their metabolites on biomarkers of sarcopenia...
March 6, 2024: Histology and Histopathology
https://read.qxmd.com/read/38497259/when-the-microbiome-shapes-the-host-immune-evolution-implications-for-infectious-disease
#9
REVIEW
Mark A Hanson
The microbiome includes both 'mutualist' and 'pathogen' microbes, regulated by the same innate immune architecture. A major question has therefore been: how do hosts prevent pathogenic infections while maintaining beneficial microbes? One idea suggests hosts can selectively activate innate immunity upon pathogenic infection, but not mutualist colonization. Another idea posits that hosts can selectively attack pathogens, but not mutualists. Here I review evolutionary principles of microbe recognition and immune activation, and reflect on newly observed immune effector-microbe specificity perhaps supporting the latter idea...
May 6, 2024: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://read.qxmd.com/read/38497023/aldosterone-methylglyoxal-and-glycated-albumin-interaction-with-macrophage-cells-affects-their-viability-activation-and-differentiation
#10
JOURNAL ARTICLE
Saee Zambre, Nilima Bangar, Armaan Mistry, Poonam Katarmal, Mohd Shahnawaz Khan, Irshad Ahmed, Rashmi Tupe, Bishnudeo Roy
BACKGROUND: The inflammatory response in diabetes is strongly correlated with increasing amounts of advanced glycation end products (AGEs), methylglyoxal (MGO), aldosterone (Aldo), and activation of macrophages. Aldo is known to be associated with increased pro-inflammatory responses in general, but its significance in inflammatory responses under glycated circumstances has yet to be understood. In the current work, the aim of our study was to study the macrophage immune response in the presence of AGEs, MGO, and Aldo to comprehend their combined impact on diabetes-associated complications...
March 12, 2024: ACS Omega
https://read.qxmd.com/read/38496906/protective-effect-of-inonotus-obliquus-polysaccharide-on-mgo-induced-nonenzymatic-glycation-fibroblasts
#11
JOURNAL ARTICLE
Chunyu Chen, Xiaoxing Liu, Yingying Lin, Li Li, Miaomiao Guo, Fan Yi
BACKGROUND: The nonenzymatic glycation of fibroblasts causes functional downregulation and behavioral disorders in the skin. METHODS: To investigate the effect of Inonotus obliquus on the nonenzymatic glycation of skin, we examined the inhibition of advanced glycation end products (AGEs) using four extraction methods: n-butanol, ethyl acetate, n-hexane and aqueous alcohol precipitation. The physical properties and chemical structure of the most effective, purified, crude I...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38496895/metformin-alleviates-junctional-epithelium-senescence-via-the-ampk-sirt1-autophagy-pathway-in-periodontitis-induced-by-hyperglycemia
#12
JOURNAL ARTICLE
Xiaoyuan Ye, Yumin Wang, Yanying Tian, Ruonan Bi, Mingyue Li, Chunyan Yang, Li Zhang, Yuguang Gao
The junctional epithelium (JE) serves a crucial protective role in the periodontium. High glucose-related aging results in accelerated barrier dysfunction of the gingival epithelium, which may be associated with diabetic periodontitis. Metformin, an oral hypoglycemic therapeutic, has been proposed as a anti-aging agent. This study aimed to clarify the effect of metformin on diabetic periodontitis and explore its mechanism in ameliorating senescence of JE during hyperglycemia. The db/db mice was used as a diabetic model mice and alterations in the periodontium were observed by hematoxylin-eosin staining and immunohistochemistry...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38496603/targeting-linc00152-activates-camp-ca-2-ferroptosis-axis-and-overcomes-tamoxifen-resistance-in-er-breast-cancer
#13
Ozge Saatci, Rashed Alam, Kim-Tuyen Huynh-Dam, Aynur Isik, Meral Uner, Nevin Belder, Pelin Gulizar Ersan, Metin Cetin, Unal Metin Tokat, Mustafa Emre Gedik, Hilal Bal, Ozlem Sener Sahin, Yasser Riazalhosseini, Denis Thieffry, Daniel Gautheret, Besim Ogretmen, Sercan Aksoy, Aysegul Uner, Aytekin Akyol, Ozgur Sahin
Tamoxifen has been the mainstay therapy to treat early, locally advanced, and metastatic estrogen receptor-positive (ER+) breast cancer, constituting around 75% of all cases. However, emergence of resistance is common, necessitating the identification of novel therapeutic targets. Here, we demonstrated that long-noncoding RNA LINC00152 confers tamoxifen resistance via blocking tamoxifen-induced ferroptosis, an iron-mediated cell death. Mechanistically, inhibiting LINC00152 reduces the mRNA stability of phosphodiesterase 4D ( PDE4D ), leading to activation of cAMP/PKA/CREB axis and increased expression of TRPC1 Ca 2+ channel...
November 5, 2023: bioRxiv
https://read.qxmd.com/read/38496404/revised-mechanism-of-hydroxyurea-induced-cell-cycle-arrest-and-an-improved-alternative
#14
Alisa E Shaw, Jackson E Whitted, Mattias N Mihelich, Hannah J Reitman, Adam J Timmerman, Grant D Schauer
Replication stress describes various types of endogenous and exogenous challenges to DNA replication in S-phase. Stress during this critical process results in helicase-polymerase decoupling at replication forks, triggering the S-phase checkpoint, which orchestrates global replication fork stalling and delayed entry into G2. The replication stressor most often used to induce the checkpoint response is hydroxyurea (HU), a chemotherapeutic agent. The primary mechanism of S-phase checkpoint activation by HU has thus far been considered to be a reduction of dNTP synthesis by inhibition of ribonucleotide reductase (RNR), leading to helicase-polymerase decoupling and subsequent activation of the checkpoint, mediated by the replisome associated effector kinase Mrc1...
March 4, 2024: bioRxiv
https://read.qxmd.com/read/38496062/atracurium-induced-bronchospasm-with-flat-capnograph-at-induction-of-general-anaesthesia-a-case-report
#15
Alfie Wright, Thomas Leahy
Benzylisoquinolinium neuromuscular blocking agents can precipitate bronchospasm either through allergy/anaphylaxis or isolated stimulation of mast cell histamine release. This report presents a 75-year-old female who attended the day surgery unit for a rigid cystoscopy under general anaesthesia. She had a hyper-reactive airway history of mild historic asthma and sensitivity to aerosols. After administration of atracurium at induction of anaesthesia, ventilation became challenging with no chest rise and a flat CO2 trace...
February 2024: Curēus
https://read.qxmd.com/read/38496047/the-nexus-of-innovation-electrochemically-synthesizing-h-2-o-2-and-its-integration-with-downstream-reactions
#16
REVIEW
Qiu Jiang, Yuan Ji, Tingting Zheng, Xu Li, Chuan Xia
Hydrogen peroxide (H2 O2 ) represents a chemically significant oxidant that is prized for its diverse applicability across various industrial domains. Recent innovations have shed light on the electrosynthesis of H2 O2 through two-electron oxygen reduction reactions (2e- ORR) or two-electron water oxidation reactions (2e- WOR), processes that underscore the attractive possibility for the on-site production of this indispensable oxidizing agent. However, the translation of these methods into practical utilization within chemical manufacturing industries remains an aspiration rather than a realized goal...
March 13, 2024: ACS Mater Au
https://read.qxmd.com/read/38495901/suppression-of-inflammation-in-adipocyte-macrophage-coculture-by-passion-fruit-seed-extract-insights-into-the-p38-and-nf-%C3%B2-b-pathway
#17
JOURNAL ARTICLE
Sukanya Chusongdam, Wanwipha Woonnoi, Furoida Moolsup, Chakkapat Aenglong, Pennapa Chonpathompikunlert, Supita Tanasawet, Jirawat Saetan, Wanida Sukketsiri
Obesity, which is characterized by chronic low-grade inflammation, involves the infiltration of immune cells into adipose tissue, leading to the secretion of inflammatory cytokines and subsequent inflammation. Therefore, the aim of this study was to examine the potential of passion fruit seed extract (PSEE) in mitigating lipopolysaccharide (LPS)-induced inflammation in a coculture system comprising macrophages and adipocytes. PSEE demonstrated significant reductions in reactive oxygen species (ROS) and nitric oxide (NO) levels, primarily achieved through the downregulation of inducible nitric oxide synthase (iNOS) protein expression in LPS-induced adipocyte-macrophage cocultures...
2024: Advances in pharmacological and pharmaceutical sciences
https://read.qxmd.com/read/38495756/plant-growth-regulators-mitigate-oxidative-damage-to-rice-seedling-roots-by-nacl-stress
#18
JOURNAL ARTICLE
Yaxin Wang, Li-Ming Zhao, Naijie Feng, Dianfeng Zheng, Xue Feng Shen, Hang Zhou, Wenxin Jiang, Youwei Du, Huimin Zhao, Xutong Lu, Peng Deng
The aim of this experiment was to investigate the effects of exogenous sprays of 5-aminolevulinic acid (5-ALA) and 2-Diethylaminoethyl hexanoate (DTA-6) on the growth and salt tolerance of rice ( Oryza sativa L.) seedlings. This study was conducted in a solar greenhouse at Guangdong Ocean University, where 'Huanghuazhan' was selected as the test material, and 40 mg/L 5-ALA and 30 mg/L DTA-6 were applied as foliar sprays at the three-leaf-one-heart stage of rice, followed by treatment with 0.3% NaCl (W/W) 24 h later...
2024: PeerJ
https://read.qxmd.com/read/38495619/the-role-of-mitochondria-in-eosinophil-function-implications-for-severe-asthma-pathogenesis
#19
REVIEW
Janice Koranteng, Kian Fan Chung, Charalambos Michaeloudes, Pankaj Bhavsar
Mitochondria are key metabolic hubs involved in cellular energy production and biosynthesis. ATP is generated primarily by glucose and fatty acid oxidation through the tricarboxylic acid (TCA) cycle and oxidative phosphorylation (OXPHOS) in the mitochondria. During OXPHOS there is also production of reactive oxygen species (ROS), which are involved in the regulation of cellular function. Mitochondria are also central in the regulating cell survival and death, particularly in the intrinsic apoptosis pathway...
2024: Frontiers in Cell and Developmental Biology
https://read.qxmd.com/read/38495545/evaluation-of-antioxidants-ability-to-enhance-hyaluronic-acid-based-topical-moisturizers
#20
JOURNAL ARTICLE
Joshua Zeichner, Tanja Bussmann, Julia M Weise, Elisabeth Maass, Andrea Krüger, Anne-Kathleen Schade, Edward Lain, Kavita Mariwalla, Frank Kirchner, Zoe D Draelos
BACKGROUND: Hyaluronic acid (HA) is a unique molecule of the extracellular matrix with multiple biological activities. In skin, HA plays an essential role as a humectant, capable of binding up to 1,000 times its mass with water, providing skin with moisture and viscoelastic properties. HA concentration and synthesis decrease significantly in aging skin, due to exogenous and endogenous factors, including photoaging and HA metabolism. A key driver for HA degradation and reduced concentration is mediated via induction of reactive oxygen species (ROS) and other free radicals...
March 2024: Journal of Clinical and Aesthetic Dermatology
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