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https://www.readbyqxmd.com/read/29793167/improvement-of-neuronal-differentiation-by-carbon-monoxide-role-of-pentose-phosphate-pathway
#1
Ana S Almeida, Nuno L Soares, Catarina O Sequeira, Sofia A Pereira, Ursula Sonnewald, Helena L A Vieira
Over the last decades, the silent-killer carbon monoxide (CO) has been shown to also be an endogenous cytoprotective molecule able to inhibit cell death and modulate mitochondrial metabolism. Neuronal metabolism is mostly oxidative and neurons also use glucose for maintaining their anti-oxidant status by generation of reduced glutathione (GSH) via the pentose-phosphate pathway (PPP). It is established that neuronal differentiation depends on reactive oxygen species (ROS) generation and signalling, however there is a lack of information about modulation of the PPP during adult neurogenesis...
May 15, 2018: Redox Biology
https://www.readbyqxmd.com/read/29792947/trail-attenuates-sulforaphane-mediated-nrf2-and-sustains-ros-generation-leading-to-apoptosis-of-trail-resistant-human-bladder-cancer-cells
#2
Cheng-Yun Jin, Ilandarage Menu Neelaka Molagoda, Wisurumuni Arachchilage Hasitha Maduranga Karunarathne, Sang-Hyuck Kang, Cheol Park, Gi-Young Kim, Yung Hyun Choi
Tumor necrosis factor-related apoptosis inducing ligand (TRAIL) can preferentially initiate apoptosis in malignant cells with minimal toxicity to normal cells. Unfortunately, many human cancer cells are refractory to TRAIL-induced apoptosis through many unknown mechanisms. Here, we report that TRAIL resistance can be reversed in human bladder cancer cell lines by treatment with sulforaphane (SFN), a well-known chemopreventive isothiocyanate in various cruciferous vegetables. Combined treatment with SFN and TRAIL (SFN/TRAIL) significantly induced apoptosis concomitant with activation of caspases, loss of mitochondrial membrane potential (MMP), Bid truncation, and induction of death receptor 5...
May 21, 2018: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29792932/cystine-glutamate-transporter-system-x-c-is-involved-in-nitric-oxide-production-in-mouse-peritoneal-macrophages
#3
Sho Kobayashi, Shinji Hamashima, Takujiro Homma, Mami Sato, Ryosuke Kusumi, Shiro Bannai, Junich Fujii, Hideyo Sato
The amino acid transport system xc - is important for maintaining intracellular glutathione levels and extracellular redox balance. The main component of system xc - , xCT, is strongly induced by various stimuli, including oxidative stress and bacterial lipopolysaccharides (LPS) in macrophages. In the present study, we investigated the production of nitric oxide by LPS-stimulated mouse peritoneal macrophages isolated from both xCT-deficient and wild-type mice. After culturing macrophages in the presence of LPS for 24-48 h, nitrite levels in the medium of xCT-deficient macrophages were significantly decreased compared to that of wild-type cells...
May 21, 2018: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/29792889/ros-triggered-degradable-iron-chelating-nanogels-safely-improving-iron-elimination-in-vivo
#4
Zhi Liu, Jing Qiao, Tamas Nagy, May P Xiong
Iron-mediated generation of highly toxic Reactive Oxygen Species (ROS) plays a major role in the process leading to iron overload-related diseases. The long-term subcutaneous administration of Deferoxamine (DFO) is currently clinically-approved to improve patient symptoms and survival. However, non-specific toxicity and short circulation times of the drug in humans often leads to poor patient compliance. Herein, thioketal-based ROS-responsive polymeric nanogels containing DFO moieties (rNG-DFO) were designed to chelate iron and to degrade under oxidative stimuli into fragments <10 nm to enhance excretion of iron-bound chelates...
May 21, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29792861/nlgn3-protects-retinal-cells-from-h-2-o-2-via-activating-nrf2-signaling
#5
Xiu-Miao Li, Dan Huang, Qing Yu, Jin Yao, Jian Yang
Intensified oxidative stress can cause severe damage to human retinal pigment epithelium (RPE) cells and retinal ganglion cells (RGCs). The potential effect of neuroligin-3 (NLGN3) against the process is studied here. Our results show that NLGN3 efficiently inhibited hydrogen peroxide (H2 O2 )-induced death and apoptosis in human RPE cells and RGCs. H2 O2 -induced reactive oxygen species (ROS) production, lipid peroxidation and DNA damage in retinal cells were alleviated by NLGN3. NLGN3 activated nuclear-factor-E2-related factor 2 (Nrf2) signaling, enabling Nrf2 protein stabilization, nuclear translocation and expression of key anti-oxidant enzymes (HO1, NOQ1 and GCLC) in RPE cells and RGCs...
May 21, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29792811/tandem-mass-spectrometry-of-peptide-ions-by-microwave-excited-hydrogen-and-water-plasmas
#6
Yuji Shimabukuro, Hidenori Takahashi, Shinichi Iwamoto, Koichi Tanaka, Motoi Wada
A thermal cracking cell that served as the atomic hydrogen source for hydrogen attachment/abstraction dissociation (HAD) analysis has an intrinsic problem to produce a beam of atoms reactive against heated tungsten capillary. A plasma excited by 2.45 GHz microwave power can deliver reactive species to a quadrupole ion trap confining analyte ions without excessive heating of the radical source components. The radical (H•) production performance of the developed source was evaluated by optical emission spectroscopy and H• attachment reaction to fullerene ions...
May 24, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29792731/apr3-modulates-oxidative-stress-and-mitochondrial-function-in-arpe-19-cells
#7
Yuan Li, Xuan Zou, Jing Gao, Ke Cao, Zhihui Feng, Jiankang Liu
Impairment of retinal pigment epithelial (RPE) cells is considered a key contributor to the development of age-related macular degeneration. Apoptosis-related protein 3 (APR3) was recently discovered after treatment with all- trans retinoic acid, a pivotal molecule in RPE cells. However, the function of APR3 remains poorly understood. In the present study, we found that APR3 could interact with nuclear factor (erythroid-derived 2)-like 2, which is a regulator of phase II enzymes, and that knockdown of APR3 promoted nuclear factor (erythroid-derived 2)-like 2 nuclear translocation and activated expression of phase II enzymes, which was accompanied by improved redox status and mitochondrial activity...
May 24, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29792682/calix-4-arene-based-redox-sensitive-molecular-probe-for-sers-guided-recognition-of-labile-iron-pool-in-tumor-cells
#8
Padincharapad Sreedevi, Jyothi B Nair, Preethanuj Preethalayam, Benadicta S Jeeja, Cherumuttathu H Suresh, Kaustabh Kumar Maiti, Ramavarma Luxmi Varma
Targeting the intracellular 'labile' iron pool is turned as a key modulator for cancer progression since the former is responsible for several pathological processes in tumor cells. Herein, we report a non- fluorescent calix[4]arene based triazole appended molecular probe (PTBC) for redox-specific detection of Fe3+ under physiological condition by UV-vis, FT-IR, 1H NMR, HR-MS spectroscopies, ITC and the binding strategy between Calix[4]arene and Fe3+ was modeled by DFT calculations. As a new insight PTBC probe showed significant Raman fingerprint through surface enhanced Raman scattering (SERS) modality revealing the ultrasensitive detection of Fe3+ with a LOD of 2 nM...
May 24, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29792415/two-photon-active-organotin-iv-complexes-for-antibacterial-function-and-superresolution-bacteria-imaging
#9
Lei Hu, Hui Wang, Tingting Xia, Bin Fang, Yu Shen, Qiong Zhang, Xiaohe Tian, Hongping Zhou, Jieying Wu, Yupeng Tian
Antibacterial agents with two-photon absorption are expected to play a significant role in biomedical science. Herein, two novel organotin complexes, HLSn1 and HLSn2, based on coumarin were designed, synthesized, and systematically investigated. It was found that these complexes possessed suitable two-photon-active cross sections in the near-infrared region. Moreover, complex HLSn1 could efficiently inhibit the growth of Gram-negative Escherichia coli and Gram-positive Bacillus subtilis, especially the latter with a minimum inhibitory concentration (MIC; 90%) of 2 ± 0...
May 24, 2018: Inorganic Chemistry
https://www.readbyqxmd.com/read/29792391/role-of-neutrophils-in-equine-asthma
#10
Benjamin Uberti, Gabriel Morán
Neutrophilic bronchiolitis is the primary lesion in asthma-affected horses. Neutrophils are key actors in host defense, migrating toward sites of inflammation and infection, where they act as early responder cells toward external insults. However, neutrophils can also mediate tissue damage in various non-infectious inflammatory processes. Within the airways, these cells likely contribute to bronchoconstriction, mucus hypersecretion, and pulmonary remodeling by releasing pro-inflammatory mediators, including the cytokines interleukin (IL)-8 and IL-17, neutrophil elastase, reactive oxygen species (ROS), and neutrophil extracellular traps (NETs)...
May 24, 2018: Animal Health Research Reviews
https://www.readbyqxmd.com/read/29792365/protective-effects-of-piceatannol-on-methylglyoxal-induced-cytotoxicity-in-mc3t3-e1-osteoblastic-cells
#11
Kwang Sik Suh, Suk Chon, Eun Mi Choi
Methylglyoxal (MG) is a reactive α-oxoaldehyde that increases under diabetic conditions and subsequently contributes to the complications associated with this disease. Piceatannol is a naturally occurring analogue of resveratrol that possesses multiple biological functions. The present study investigated the effects of piceatannol on MG-induced cytotoxicity in MC3T3-E1 osteoblastic cells. Piceatannol significantly restored MG-induced reductions in cell viability and reduced lactate dehydrogenase release in MG-treated MC3T3-E1 osteoblastic cells, which suggests that it suppressed MG-induced cytotoxicity...
June 2018: Free Radical Research
https://www.readbyqxmd.com/read/29792199/nanoparticle-delivery-of-grape-seed-derived-proanthocyanidins-to-airway-epithelial-cells-dampens-oxidative-stress-and-inflammation
#12
S Castellani, A Trapani, A Spagnoletta, L di Toma, T Magrone, S Di Gioia, D Mandracchia, G Trapani, E Jirillo, M Conese
BACKGROUND: Chronic respiratory diseases, whose one of the hallmarks is oxidative stress, are still incurable and need novel therapeutic tools and pharmaceutical agents. The phenolic compounds contained in grape are endowed with well-recognized anti-oxidant, anti-inflammatory, anti-cancer, and anti-aging activities. Considering that natural anti-oxidants, such as proanthocyanidins, have poor water solubility and oral bioavailability, we have developed a drug delivery system based on solid lipid nanoparticles (SLN), apt to encapsulate grape seed extract (GSE), containing proanthocyanidins...
May 23, 2018: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29792156/design-synthesis-and-biological-evaluation-of-1h-1-2-3-triazole-linked-1h%C3%A2-dibenzo-b-h-xanthenes-as-inductors-of-ros-mediated-apoptosis-in-the-breast-cancer-cell-line-mcf-7
#13
Carolina S Bortolot, Luana da S M Forezi, Roberta K F Marra, Marcelo I P Reis, Barbara V F E Sa, Ricardo Imbroisi Filho, Zeinab Ghasemishahrestani, Mauro Sola-Penna, Patricia Zancan, Vitor F Ferreira, Fernando de C da Silva
BACKGROUND: Low molecular weight 1,2,3-triazoles and naphthoquinones are endowed with various types of biological activity, such as against cancer, HIV and bacteria. However, in some cases, the conjugation of these two nuclei considerably increases their biological activities Objective: In this work, we decided to study the synthesis and screening of bis-naphthoquinones and xanthenes tethered to 1,2,3-triazoles against cancer cell lines, specifically the human breast cancer cell line MCF-7...
May 23, 2018: Medicinal Chemistry
https://www.readbyqxmd.com/read/29791845/equilibrative-nucleoside-transporter-3-regulates-t-cell-homeostasis-by-coordinating-lysosomal-function-with-nucleoside-availability
#14
Chin-Wen Wei, Chia-Ying Lee, Ding-Jin Lee, Chang-Feng Chu, Ju-Chu Wang, Tien-Chiao Wang, Wann-Neng Jane, Zee-Fen Chang, Chuen-Miin Leu, Ivan L Dzhagalov, Chia-Lin Hsu
T cells are a versatile immune cell population responding to challenges by differentiation and proliferation followed by contraction and memory formation. Dynamic metabolic reprogramming is essential for T cells to meet the biosynthetic needs and the reutilization of biomolecules, processes that require active participation of metabolite transporters. Here, we show that equilibrative nucleoside transporter 3 (ENT3) is highly expressed in peripheral T cells and has a key role in maintaining T cell homeostasis by supporting the proliferation and survival of T cells...
May 22, 2018: Cell Reports
https://www.readbyqxmd.com/read/29791833/maternal-and-postnatal-high-fat-diets-with-high-6-3-ratios-affect-the-reproductive-performance-of-male-offspring-in-the-mouse
#15
S Bianconi, G Stutz, M R Solís, A C Martini, L M Vincenti, M F Ponzio, E Luque, C Avendaño, P Quiroga, M E Santillán
High-fat diets (HFDs) are an acknowledged risk factor for male subfertility, but the underlying mechanisms remain unclear. In the present study we compared the effects of two HFDs with different ω6:ω3 ratios, one enriched with soy oil (SOD; ω6:ω3=9.62) and another enriched with sunflower oil (SFOD; ω6:ω3=51.55), with those of a commercial diet (CD; ω6:ω3=19.87), supplied from pregnancy to adulthood, on morphometric parameters and reproductive performance in adult male mice (recommended ω6:ω3 for rodents=1-6)...
May 24, 2018: Reproduction, Fertility, and Development
https://www.readbyqxmd.com/read/29791805/identifying-the-nonradical-mechanism-in-the-peroxymonosulfate-activation-process-singlet-oxygenation-versus-mediated-electron-transfer
#16
Eun-Tae Yun, Jeong Hoon Lee, Jaesung Kim, Hee-Deung Park, Jaesang Lee
Select persulfate activation processes were demonstrated to initiate oxidation not reliant on sulfate radicals, though the underlying mechanism has yet to be identified. This study explored singlet oxygenation and mediated electron transfer as plausible nonradical mechanisms for organic degradation by carbon nanotube (CNT)-activated peroxymonosulfate (PMS). The degradation of furfuryl alcohol (FFA) as a singlet oxygen (1O2) indicator and the kinetic retardation of FFA oxidation in the presence of L-histidine and azide as 1O2 quenchers apparently supported a role of 1O2 in the CNT/PMS system...
May 23, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29791149/a-tricopper-i-complex-competent-for-o-atom-transfer-c-h-bond-activation-and-multiple-o-2-activation-steps
#17
Brian J Cook, Gianna N Di Francesco, Matthew T Kieber-Emmons, Leslie J Murray
Oxygenation of a tricopper(I) cyclophanate (1) affords reactive transients competent for C-H bond activation and O atom transfer to various substrates (including toluene, dihydroanthracene, and ethylmethylsulfide) based on 1 H NMR, gas chromatography/mass spectrometry (MS), and electrospray ionization (ESI)/MS data. Low product yields (<1%) are determined for C-H activation substrates (e.g, toluene, ethylbenzene), which we attribute to competitive ligand oxidation. The combined stopped-flow UV/visible, electron paramagnetic resonance, ESI/MS, 1 H NMR, and density functional theory (DFT) results for reaction of 1 with O2 are consistent with transient peroxo- and di(oxo)-bridged intermediates...
May 23, 2018: Inorganic Chemistry
https://www.readbyqxmd.com/read/29790749/anti-inflammatory-activity-of-8-hydroxydaidzein-in-lps-stimulated-bv2-microglial-cells-via-activation-of-nrf2-antioxidant-and-attenuation-of-akt-nf-%C3%AE%C2%BAb-inflammatory-signaling-pathways-as-well-as-inhibition-of-cox-2-activity
#18
Pei-Shan Wu, Hsiou-Yu Ding, Jui-Hung Yen, Shu-Fen Chen, Kuan-Han Lee, Ming-Jiuan Wu
It was demonstrated that isoflavones can cross the blood-brain barrier, making them desirable candidate agents for the prevention of neurological symptoms. 8-Hydroxydaidzein (8-OHD, 4',7,8-trihydoxyisoflavone) is an isoflavone found only in fermented soy food. Current results showed that 8-OHD inhibited LPS-stimulated production of nitric oxide (NO) and proinflammatory cytokines, such as tumor necrosis factor (TNF)-α and interleukin (IL)-6, by inhibiting gene expression in BV2 microglial cells. Moreover, 8-OHD markedly quenched reactive oxygen species (ROS) and activated NF-E2-related factor 2 (Nrf2) so as to upregulate expression of Phase II enzymes, including heme oxygenase (HO)-1, NAD(P)H quinone dehydrogenase 1 (NQO1), and the modifier subunit of glutamate cysteine ligase (GCLM)...
May 23, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29790387/crosstalk-between-connexin-32-and-mitochondrial-apoptotic-signaling-pathway-plays-a-pivotal-role-in-renal-ischemia-reperfusion-induced-acute-kidney-injury
#19
Chaojin Chen, Yao Weifeng, Wu Shan, Zhou Shaoli, Gu Yu, Ge Mian, Li Xiang, Guihua Chen, Joseph A Bellanti, Songguo Zheng, Dongdong Yuan, Ziqing Hei
AIMS: Perioperative acute kidney injury (AKI) resulting from renal ischemia reperfusion (IR) is not conducive to the postoperative surgical recovery. Our previous study demonstrated that reactive oxygen species (ROS) transmitted by gap junction (GJ) composed of connexin32 (Cx32) contributed to AKI. However, the precise pathophysiologic mechanisms were unknown. The present study focuses on the underlying mechanisms related to ROS transmitted by Cx32 responsible for AKI aggravation. RESULTS: In a set of vivo studies, renal IR was found to cause severe impairment in renal tissues with massive ROS generation, and occurred contemporaneously with activation of NF-κB/p53/PUMA-mediated mitochondrial apoptosis pathways...
May 23, 2018: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/29790350/glutaredoxin-deletion-shortens-chronological-life-span-in-saccharomyces-cerevisiae-via-ros-mediated-ras-pka-activation
#20
Yan Liu, Fan Yang, Siying Li, Junbiao Dai, Haiteng Deng
Glutaredoxins (GRXs), small redox proteins that use reduced glutathione (GSH) as an electron donor, are key components of the cellular antioxidant system. In this study, we used Saccharomyces cerevisiae as a model system to investigate the effects of GRX deletion on yeast chronological life span (CLS). Deletion of either Grx1 or Grx2 shortened yeast CLS. Quantitative proteomics revealed that GRX deletion decreased expression of stress-response proteins, leading to increased cellular reactive oxygen species (ROS) accumulation and, subsequently, intracellular acidification...
May 23, 2018: Journal of Proteome Research
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