keyword
https://read.qxmd.com/read/38515369/adjunctive-use-of-hyperbaric-oxygen-therapy-in-veterinary-dentistry-and-oral-surgery-a-case-series
#21
JOURNAL ARTICLE
Melanie Hunt, Danielle Mendelsohn, Katherine Queck, Carlos Rice
Hyperbaric oxygen therapy (HBOT) is utilized as an adjunctive treatment for human and veterinary patients with compromised tissues. Medical records from two veterinary hospitals with HBOT chambers were searched for small animal veterinary dentistry and oral surgery specialty patients. The HBOT records were combined with the medical records from the referring specialty veterinary dentistry and oral surgery services. Clinical indications for HBOT treatments associated with a positive outcome in this case series included resistant bacterial infections, electrical cord injury, bite wound injuries, osteomyelitis, crush/traumatic injuries including mandibular fractures, oral surgery performed at previously irradiated sites, and osteonecrosis, presumably radiation induced...
March 22, 2024: Journal of Veterinary Dentistry
https://read.qxmd.com/read/38513152/intercalary-resection-of-the-tibia-for-primary-bone-tumors-are-vascularized-fibula-autografts-with-or-without-allografts-a-durable-reconstruction
#22
JOURNAL ARTICLE
Domenico Andrea Campanacci, Roberto Scanferla, Mariagrazia Marsico, Federico Scolari, Guido Scoccianti, Giovanni Beltrami, Luca Delcroix, Marco Innocenti, Rodolfo Capanna
BACKGROUND: Reconstruction with vascularized fibula grafts (VFG) after intercalary resection of sarcoma may offer longevity by providing early graft-host union and fracture healing. The ability of the fibula to hypertrophy under mechanical stress, as well as vascularized bone in the area, may also be advantageous, given that soft tissues may be compromised because of resection, chemotherapy, or radiation therapy. VFG with a massive allograft combines the primary mechanical stability of the graft with the biological potential of the vascularized fibula; however, complications and the durability of this combined reconstruction are not well described...
March 21, 2024: Clinical Orthopaedics and related Research
https://read.qxmd.com/read/38510622/single-and-multilevel-corpectomy-and-vertebral-body-replacement-for-treatment-of-spinal-infections-a-retrospective-single-center-study-of-100-cases
#23
JOURNAL ARTICLE
J Neuhoff, O Berkulian, A Kramer, S Thavarajasingam, A Wengert, P Schleicher, A Pingel, F Kandziora
BACKGROUND: The optimal operative approach for treating spinal infections remains a subject of debate. Corpectomy and Vertebral Body Replacement (VBR) have emerged as common modalities, yet data on their feasibility and complication profiles are limited. METHODS: This retrospective single-center study examined 100 consecutive cases (2015-2022) that underwent VBR for spinal infection treatment. A comparison between Single-level-VBR and Multi-level-VBR was performed, evaluating patient profiles, revision rates, and outcomes...
2024: Brain Spine
https://read.qxmd.com/read/38508732/-hereditary-sensory-and-autonomic-neuropathy-1e-showing-hyperreflexia-a-case-report
#24
JOURNAL ARTICLE
Hitoshi Hayashida, Yukimasa Arita, Kishin Koh, Yoshihisa Takiyama, Koji Ikezoe
A 52-year-old man had developed hearing loss since childhood, as well as recurrent foot ulcers and osteomyelitis since his forties. He presented with gait disturbance and dysarthria that had worsened over four years and a month, respectively. Neurological exams revealed cognitive impairment, proximal weakness of the lower extremities, generalized hyperrflexia, ataxia, sensory disturbances predominant in deep sensation, urinary retention, and gait instability. On nerve conduction study, no sensory nerve action potentials were evoked in the upper and lower limbs...
March 20, 2024: Rinshō Shinkeigaku, Clinical Neurology
https://read.qxmd.com/read/38508383/use-of-recombinant-human-bone-morphogenetic-protein-2-after-anterior-cervical-corpectomy-and-fusion-for-the-treatment-of-vertebral-osteomyelitis
#25
JOURNAL ARTICLE
Adriana Vazquez Medina, Gisela Murray Ortiz, Samuel Estronza Ojeda, Aixa de Jesus Espinosa, Emil A Pastrana
OBJECTIVE: To report the operative outcomes after treating vertebral osteomyelitis patients with an anterior cervical corpectomy and fusion procedure using recombinant human bone morphogenetic protein-2 as graft material. MATERIALS AND METHODS: A retrospective review of electronic medical records of 26 adult patients who underwent an anterior cervical corpectomy and fusion procedure for cervical osteomyelitis using rhBMP-2 at the University of Puerto Rico University District Hospital was performed...
March 18, 2024: World Neurosurgery
https://read.qxmd.com/read/38505897/the-impact-of-patient-characteristics-on-outcomes-of-surgically-managed-vertebral-osteomyelitis-in-the-united-states-insights-from-a-national-database-study
#26
JOURNAL ARTICLE
Jennifer Kurowicki, Stuart Changoor, Daniel Coban, Neil Patel, Kumar Sinha, Ki Hwang, Arash Emami
This study was conducted to assess the patient characteristics, types of treatment, and outcomes of patients who are surgically treated for vertebral osteomyelitis (VO) in the United States. VO can be treated with or without surgical intervention. Surgically treated cases of VO are associated with significant morbidity and mortality, and incur major healthcare costs. There are few studies assessing the characteristics and outcomes of patients with VO who are treated surgically, as well as the overall impact of surgically managed VO on the healthcare system of the United States...
2024: Journal of Long-term Effects of Medical Implants
https://read.qxmd.com/read/38505636/myocardial-calcification-an-unusual-complication-of-remote-trauma-with-coidentified-amyloidosis
#27
Zachary Alan Wilkinson, Alison Krywanczyk
We present the heart of a 38-year-old man with paraplegia due to a remote traumatic spinal cord injury. In the 20 years following his injury, he experienced chronic decubitus ulcers, osteomyelitis, neurogenic bladder, malnutrition, and urinary tract infections. He was admitted to the hospital with septic shock secondary to multiple decubitus ulcers and osteomyelitis and expired after a two-month hospitalization. At autopsy, there was marked replacement of left ventricle and interventricular septal myocardium by gritty, firm, yellow-white tissue...
March 2024: Academic Forensic Pathology
https://read.qxmd.com/read/38505530/staphylococcus-aureus-panton-valentine-leukocidin-worsens-acute-implant-associated-osteomyelitis-in-humanized-brgsf-mice
#28
JOURNAL ARTICLE
Marloes I Hofstee, Claudia Siverino, Motoo Saito, Himanshu Meghwani, James Tapia-Dean, Samson Arveladze, Maria Hildebrand, Javier Rangel-Moreno, Martijn Riool, Stephan Zeiter, Sebastian A J Zaat, T Fintan Moriarty, Gowrishankar Muthukrishnan
Staphylococcus aureus is the most common pathogen that causes implant-associated osteomyelitis, a clinically incurable disease. Immune evasion of S. aureus relies on various mechanisms to survive within the bone niche, including the secretion of leukotoxins such as Panton-Valentine leukocidin (PVL). PVL is a pore-forming toxin exhibiting selective human tropism for C5a receptors (C5aR1 and C5aR2) and CD45 on neutrophils, monocytes, and macrophages. PVL is an important virulence determinant in lung, skin and soft tissue infections...
February 2024: JBMR Plus
https://read.qxmd.com/read/38505528/-18-f-sodium-fluoride-pet-ct-visualizes-disease-activity-in-chronic-nonbacterial-osteitis-in-adults
#29
JOURNAL ARTICLE
Anne T Leerling, Frits Smit, Zita Spӓth, Ana Navas Cañete, Lioe-Fee de Geus-Oei, Alina van de Burgt, Olaf M Dekkers, Wouter van der Bruggen, Natasha M Appelman-Dijkstra, Dennis Vriens, Elizabeth M Winter
Chronic nonbacterial osteitis (CNO) is a rare disease spectrum, which lacks biomarkers for disease activity. Sodium fluoride-18 positron emission tomography/computed tomography ([18 F]NaF-PET/CT) is a sensitive imaging tool for bone diseases and yields quantitative data on bone turnover. We evaluated the capacities of [18 F]NaF-PET/CT to provide structural and functional assessment in adult CNO. A coss-sectional study was performed including 43 adult patients with CNO and 16 controls (patients referred for suspected, but not diagnosed with CNO) who underwent [18 F]NaF-PET/CT at our expert clinic...
February 2024: JBMR Plus
https://read.qxmd.com/read/38504031/bacterial-osteomyelitis-in-pediatric-patients-a-comprehensive-review
#30
REVIEW
Ricardo Restrepo, Halley J Park, S Pinar Karakas, Luisa F Cervantes, Felipe G Rodriguez-Ruiz, Anna Maria Zahrah, Emilio J Inarejos-Clemente, Marcelo Laufer, Verena M Shreiber
Bacterial osteomyelitis, an inflammatory response in the bone caused by microorganisms, typically affects the metaphysis in the skeletally immature. Bacterial osteomyelitis possesses a significant diagnostic challenge in pediatric patients due to its nonspecific clinical presentation. Because the metaphysis is the primary focus of infection in skeletally immature patients, understanding the normal physiologic, maturation process of bones throughout childhood allows to understand the pathophysiology of osteomyelitis...
March 20, 2024: Skeletal Radiology
https://read.qxmd.com/read/38503690/extended-spectrum-beta-lactamase-escherichia-coli-diabetic-foot-osteomyelitis-causing-sausage-toe-deformity-successful-therapy-with-ertapenem-in-the-outpatient-setting
#31
JOURNAL ARTICLE
Georgios S Papaetis, Elena A Dionysiou, Ifigenia S Charalambous, Panagiotis T Doukanaris
BACKGROUND Diabetic foot osteomyelitis is a high-morbidity and debilitating complication of diabetic foot ulcers that contributes to significantly worse quality of life in the affected population and higher cost of healthcare services. One of the clinical presentations of diabetic foot osteomyelitis is the 'sausage' toe deformity, which affects the phalanges (local soft tissue infection and underlying bony changes). This deformity is highly suggestive of the presence of osteomyelitis. Unfortunately, during recent years, the emergence of antibiotic-resistant bacteria have created great difficulties in choosing appropriate empirical antibiotics for the treatment of diabetic foot infections...
March 8, 2024: American Journal of Case Reports
https://read.qxmd.com/read/38499893/geriatric-chronic-recurrent-multifocal-osteomyelitis-crmo-mimicking-multifocal-multiple-myeloma-a-first-in-an-octogenarian
#32
JOURNAL ARTICLE
Jonathan Sgaglione, Andrew Muran, Matthew Rhode, Howard J Goodman, Morris C Edelman, Suhail Ahmed Shah, Andrew S Greenberg, Shachar Kenan
Chronic recurrent multifocal osteomyelitis (CRMO), an autoinflammatory bone disorder characterized by non-bacterial osteomyelitis causing recurrent multifocal bone lesions, is a well-known, yet uncommon pediatric condition that rarely affects adults; to date, it has never been diagnosed over the age of 75. The following report will discuss the first octogenarian diagnosed with CRMO and therefore represents an exceptionally rare presentation of a rare disease. An 83-year-old woman presented with progressive right shoulder, forearm, and hip pain, with associated weight loss and global weakness, requiring a wheelchair for mobility...
March 19, 2024: Skeletal Radiology
https://read.qxmd.com/read/38499694/epidemiology-and-risk-factors-for-extension-of-necrotizing-otitis-externa
#33
JOURNAL ARTICLE
Elise Krawiec, Esteban Brenet, France Truong, Yohan Nguyen, Dimitri Papthanassiou, Marc Labrousse, Xavier Dubernard
PURPOSE: Necrotizing otitis externa (OEN) is an aggressive and morbid infection of the external acoustic meatus. What are the risk factors for OEN extension? METHODS: French monocentric retrospective study (2004-2021), including patients with OEN defined by the association of an inflamed EAM, a positive nuclear imaging, the presence of a bacteriological sample and the failure of a well-followed local and/or general antibiotic treatment. OEN was extensive if it was associated with vascular or neurological deficits, if nuclear imaging fixation and/or bone lysis extended beyond the tympanic bone...
March 18, 2024: European Archives of Oto-rhino-laryngology
https://read.qxmd.com/read/38498913/mycobacterium-xenopi-vertebral-osteomyelitis-in-a-patient-with-systemic-lupus-erythematosus-illustrative-case
#34
JOURNAL ARTICLE
Ryan Kelly, Josha Woodward, Jacob B Gerzenshtein, Mariam Aziz, John E O'Toole
BACKGROUND: Mycobacterium xenopi is a common nontuberculous Mycobacterium (NTM) that is slow growing and an infrequent cause of infection. When infections do occur, it is by exposure to contaminated soil or water or to infectious aerosols. Nontuberculous mycobacterial infections in the spine are exceedingly rare. Risk factors can include immunosuppression, particularly human immunodeficiency virus; however, other systemic diseases such as systemic lupus erythematosus (SLE) have been reported...
March 18, 2024: J Neurosurg Case Lessons
https://read.qxmd.com/read/38496839/bibliometric-analysis-of-systematic-review-and-meta-analysis-on-diabetic-foot-ulcer
#35
JOURNAL ARTICLE
Yanyan Wang, Cong Wang, Lei Zheng
Many clinical management strategies have been proposed to deal with diabetic foot ulcers. However, the occurrence and recurrence of foot ulcers remain the major problems for diabetics. This study aims to identify, visualize, and characterize the meta-analyses on diabetic foot ulcer research. Articles published online were retrieved from the Web of Science core collection database using a search query incorporating MeSH terms and topics related to diabetic foot ulcers and meta-analysis. The publications were then analyzed for basic characteristics, including publication year, countries, topics covered, references, and keywords discussed in the articles...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38496112/munchausen-syndrome-in-the-context-of-liaison-psychiatry-a-case-report-and-a-narrative-review
#36
Odete Nombora, Eva Mendes, André Oliveira, Lúcia Ribeiro
Munchausen Syndrome (MS) has been widely recognized as a severe manifestation of factitious disorder, a condition where individuals intentionally fabricate or exaggerate symptoms for psychological gratification. It represents a complex diagnostic challenge due to its elusive nature and intricate relationship with various medical conditions. We present a clinical case of a 44-year-old woman observed in the context of Liaison Psychiatry, demonstrating the intricate interplay between chronic medical conditions, psychiatric factors, and the challenges in diagnosing and managing MS...
February 2024: Curēus
https://read.qxmd.com/read/38496067/osteomyelitis-of-frontal-sinus-a-rare-sequelae-of-acute-bacterial-sinusitis-associated-with-anatomical-variations-in-the-frontal-sinus-drainage-pathway
#37
Smriti Wadhwa, Shraddha Jain, Jaya Gupta, Harshil Dobariya, Nikhil Pantbalekundri
Frontal osteomyelitis is characterized by localized osteal inflammation of the frontal bone. This is a rare complication of acute frontal sinusitis. The present case is being reported to highlight the likely role of anatomical variations in frontal sinus drainage pathways in the causation of this complication apart from other known predisposing factors like young age and immunocompromised state. The patient initially presented with seizures, fever, and headache and was diagnosed with viral encephalitis. However, the symptoms gradually progressed to cause right eye swelling and an increase in the severity of headache without any nasal complaints...
February 2024: Curēus
https://read.qxmd.com/read/38492335/examining-the-causal-relationship-between-circulating-immune-cells-and-the-susceptibility-to-osteomyelitis-a-mendelian-randomization-study
#38
JOURNAL ARTICLE
Chun-Gui Liu, Dong-Yang Li, Xi Gao, Teng Ma, Kun Zhang, De-Yin Liu
BACKGROUND: Osteomyelitis is considered as a deleterious inflammatory condition affecting the bone, primarily attributed to pathogenic infection. However, the underlying factors predisposing individuals to osteomyelitis remain incompletely elucidated. The immune system plays a multifaceted role in the progression of this condition, yet previous observational studies and randomized controlled trials investigating the association between circulating immune cell counts and osteomyelitis have been constrained...
March 15, 2024: International Immunopharmacology
https://read.qxmd.com/read/38491234/differential-diagnosis-of-diabetic-foot-osteomyelitis-and-charcot-neuropathic-osteoarthropathy-with-deep-learning-methods
#39
JOURNAL ARTICLE
Maide Cakir, Gökalp Tulum, Ferhat Cuce, Kerim Bora Yilmaz, Ayse Aralasmak, Muhammet İkbal Isik, Hüseyin Canbolat
Our study aims to evaluate the potential of a deep learning (DL) algorithm for differentiating the signal intensity of bone marrow between osteomyelitis (OM), Charcot neuropathic osteoarthropathy (CNO), and trauma (TR). The local ethics committee approved this retrospective study. From 148 patients, segmentation resulted in 679 labeled regions for T1-weighted images (comprising 151 CNO, 257 OM, and 271 TR) and 714 labeled regions for T2-weighted images (consisting of 160 CNO, 272 OM, and 282 TR). We employed both multi-class classification (MCC) and binary-class classification (BCC) approaches to compare the classification outcomes of CNO, TR, and OM...
March 15, 2024: J Imaging Inform Med
https://read.qxmd.com/read/38491225/pictorial-review-challenges-in-distinguishing-bilateral-metaphyseal-marrow-abnormalities-on-magnetic-resonance-imaging
#40
JOURNAL ARTICLE
Sean M Booth, Tejas H Kapadia, Vivian Tang, Amit F Maniyar
The paediatric metaphysis is afflicted by a wide range of pathological processes as it is the most metabolically active and well-vascularised part of the developing skeleton. This review focuses on metaphyseal marrow signal change detected with magnetic resonance imaging, which is most often occult on radiographs. When bilateral, these imaging appearances frequently present a diagnostic quandary. This review assists the radiologist to confidently dismiss physiological signal change and confidently work through the differential diagnosis...
March 16, 2024: Pediatric Radiology
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