keyword
https://read.qxmd.com/read/38547389/clinical-and-radiological-septic-joint-analysis-of-spontaneous-sternoclavicular-joint-infections-achieving-the-best-outcomes-a-systems-engineering-approach
#1
JOURNAL ARTICLE
Tanushri Pothini, Charles D Wilmot, John K Waters, Michael A Wait, Scott I Reznik, Kirk G Jordan, Jacqueline T Caire, John M Ashworth, Leah C Cady, Jerzy R Lysikowski, Christina F Yen, Robert C Weinschenk, Richard Samade, Michael E Jessen, Andrew Kusiak, Kemp H Kernstine
PURPOSE: Spontaneous sternoclavicular joint infection (SSCJI) is a rare and poorly understood disease process. This study aims to identify factors guiding effective management strategies for SSCJI by using data mining. METHODS: An IRB-approved retrospective review of patients from two large hospitals (2010 to 2022) was conducted. Spontaneous sternoclavicular joint infection is defined as a joint infection without direct trauma or radiation, direct instrumentation, or contiguous spread...
March 28, 2024: European Journal of Cardio-thoracic Surgery
https://read.qxmd.com/read/38546315/septic-arthritis-of-the-sternoclavicular-joint
#2
JOURNAL ARTICLE
George V Koshy, Richard Davis, Christopher Wilson
INTRODUCTION: Sternoclavicular joint (SCJ) septic arthritis is a rare but rapidly fatal joint infection. Without proper medical or surgical management, it can progress to osteomyelitis, chest wall abscess, mediastinitis, or myositis. CASE REPORT: A 57-year-old male with a past history of intravenous drug use presented to the emergency department (ED) with chest tenderness of one week duration. Vital signs were unremarkable, and exam was notable for tender, raised right SCJ without any fluctuance...
February 2024: Clinical Practice and Cases in Emergency Medicine
https://read.qxmd.com/read/38544962/squamous-cell-carcinoma-arising-from-chronic-osteomyelitis-of-the-femur-a-case-report
#3
Nan Jiang, Yu-Sheng Yang, Qing-Rong Lin, Yan-Jun Hu, Bin Yu
Although chronic osteomyelitis (COM) affecting the extremities is a frequently occurring disease, the incidence of squamous cell carcinoma (SCC) arising from COM is rare. Consequently, understanding the diagnosis, treatment and prognosis of such a disorder remains limited. In the present study, a case of COM-associated SCC was demonstrated. A 65-year-old woman arrived to the Southern Medical University Nanfang Hospital (Guangzhou, China) with multiple sinus tracts and skin ulcers in the distal part of her left thigh, persisting for over 50 years following an open pierce injury by an ox horn...
May 2024: Biomedical Reports
https://read.qxmd.com/read/38541644/the-vascularized-fibula-as-salvage-procedure-in-extremity-reconstruction-a-retrospective-analysis-of-time-to-heal-and-possible-confounders
#4
JOURNAL ARTICLE
Christian Smolle, Judith C J Holzer-Geissler, Patrick Mandal, Jessica Schwaller, Gert Petje, Johannes Rois, Lars-Peter Kamolz, Werner Girsch
The vascularized fibula transfer is a well-established technique for extremity reconstruction, but operative planning and patient selection remains crucial. Although recently developed techniques for bone reconstruction, such as bone segment transfer, are becoming increasingly popular, bone defects may still require vascularized bone grafts under certain circumstances. In this study, 41 cases, 28 (68%) men and 13 (32%) women (median age: 40 years), were retrospectively analyzed. Therapy-specific data (flap vascularity [free vs...
February 28, 2024: Life
https://read.qxmd.com/read/38541108/infective-endocarditis-by-capnocytophaga-species-a-narrative-review
#5
REVIEW
Despoina Spentzouri, Stella Baliou, Petros Ioannou
Bacteria belonging to the genus Capnocytophaga are thin, capnophilic, Gram-negative bacilli with tapered ends that include nine species that are isolated from the mouth of humans and animals and, from a phylogenetical perspective, they belong to the family Flavobacteriaceae . Two more species, namely C. endodontalis and C. stomatis have been recovered from a periapical abscess and human and animal infections, respectively. Capnocytophaga spp. can cause serious and potentially life-threatening infections in humans, such as bacteremia and meningitis, most commonly in the context of penetrating trauma as a result of contact with animals, especially after animal bites...
February 24, 2024: Medicina
https://read.qxmd.com/read/38540007/use-of-a-custom-made-patellar-groove-replacement-in-an-american-staffordshire-terrier-puppy-with-a-severe-bone-defect-in-the-femoral-trochlea-caused-by-hematogenous-osteomyelitis
#6
Enrico Panichi, Sara Sassaroli, Giorgio Maria Ciccarese, Valentina Riccio, Caterina Balestriere, Marco Barbaccia, Fulvio Cappellari, Ekaterina Burkhan, Angela Palumbo Piccionello
An 8-month-old male American Staffordshire terrier was referred for a no-weightbearing lameness of the right pelvic limb, hyperthermia, lethargy and inappetence. Two months before, endocarditis was diagnosed and treated in another veterinary hospital. Orthopedic, radiographic and tomographic examinations revealed a bone sequestrum of 4 × 1.4 cm and active periosteal reaction of the caudo-lateral cortical in the metaphysis and the distal third of the right femoral diaphysis, medullary osteolysis and interruption of the cranio-medial cortical profile, with involvement of the femoral trochlea leading to a secondary medial patella luxation...
March 15, 2024: Animals: An Open Access Journal From MDPI
https://read.qxmd.com/read/38539335/pediatric-patients-with-osteomyelitis-and-or-septic-joint-undergoing-surgical-debridement-have-equivalent-short-term-outcomes-with-or-without-preoperative-mri
#7
JOURNAL ARTICLE
E Graham Englert, Collin L Braithwaite, Maria E Aguirre-Flores, Aaron W Lam, Mohamed Sarraj, Abigail Kumagai, E Dimitra Bednar, Adam M Gordon, Ibrahim Salama, Jacob Keeley, Indu Pathak, Waleed Kishta, Ahmed M Thabet, Amr Abdelgawad, Ehab Saleh
The purpose of this study was to determine if short-term outcomes differed for pediatric patients with suspected musculoskeletal infection with or without a preoperative MRI. This was a multicenter, retrospective review of patients aged 0-16 years who presented with atraumatic extremity pain, underwent irrigation and debridement (I&D), and received at least one preoperative or postoperative MRI over a 10-year period. Primary outcomes were time to OR, total I&Ds, readmission rate, time from OR to discharge, and total number of MRIs...
March 2, 2024: Children
https://read.qxmd.com/read/38537273/eradication-of-staphylococcus-aureus-in-implant-associated-osteomyelitis-by-an-injectable-in-situ-forming-depot-antibiotics-delivery-system
#8
JOURNAL ARTICLE
Albert Juan Fuglsang-Madsen, Nicole Lind Henriksen, Elizabeth Serrano Chávez, Lasse Andersson Kvich, Julie Knippel Melsted Birch, Katrine Top Hartmann, Thomas Eriksen, Thomas Bjarnsholt, Hans Gottlieb, Thomas Lars Andresen, Louise Kruse Jensen, Jonas Rosager Henriksen, Anders Elias Hansen
BACKGROUND: Bone infections from Staphylococcus aureus are notoriously difficult to treat and have high recurrence rates. Local antibiotic delivery systems hold the potential to achieve high in situ antibiotic concentrations, which are otherwise challenging to achieve via systemic administration. Existing solutions have been shown to confer suboptimal drug release and distribution. Here we present and evaluate an injectable in situ-forming depot system termed CarboCell. The CarboCell technology provides sustained and tuneable release of local high-dose antibiotics...
March 27, 2024: Journal of Infectious Diseases
https://read.qxmd.com/read/38534643/evaluation-of-the-potential-of-chitosan-nanoparticles-as-a-delivery-vehicle-for-gentamicin-for-the-treatment-of-osteomyelitis
#9
JOURNAL ARTICLE
Elliot Simpson, Humera Sarwar, Iain Jack, Deborah Lowry
Chitosan nanoparticle delivery systems have the potential for enhancing bone healing and addressing osteomyelitis. The objective was to deliver antimicrobial agents capable of preventing or treating osteomyelitis. Each formulation was optimized to achieve desired characteristics in terms of size (ranging from 100 to 400 nm), PDI (less than 0.5), zeta potential (typically negative), and in vitro release profiles for gentamicin. Entrapment percentages varied with gentamicin ranging from 10% to 65%. The chitosan nanoparticles exhibited substantial antimicrobial efficacy, particularly against P...
February 22, 2024: Antibiotics
https://read.qxmd.com/read/38533511/bones-on-fire-illuminating-osteomyelitis-through-the-radiant-lens-of-18-f-fdg-pet-ct
#10
REVIEW
Mei Yang, Quanhui Tan, Zhenghao Tang
Osteomyelitis is an inflammatory process that is caused by an infecting microorganism and leads to progressive bone destruction and loss. Osteomyelitis can occur at any age and can involve any bone. The infection can be limited to a single portion of the bone or can involve several regions, such as marrow, cortex, periosteum, and the surrounding soft tissue. Early and accurate diagnosis plays a crucial role in reducing unnecessary treatment measures, improving the patient's prognosis, and minimizing time and financial costs...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38532027/diagnostic-imaging-of-the-diabetic-foot-an-eanm-evidence-based-guidance
#11
JOURNAL ARTICLE
Chiara Lauri, Edel Noriega-Álvarez, Riddhika M Chakravartty, Olivier Gheysens, Andor W J M Glaudemans, Riemer H J A Slart, Thomas C Kwee, Frédéric Lecouvet, Emmanouil Panagiotidis, Jules Zhang-Yin, Jose Luis Lazaro Martinez, Benjamin A Lipsky, Luigi Uccioli, Alberto Signore
PURPOSE: Consensus on the choice of the most accurate imaging strategy in diabetic foot infective and non-infective complications is still lacking. This document provides evidence-based recommendations, aiming at defining which imaging modality should be preferred in different clinical settings. METHODS: This working group includes 8 nuclear medicine physicians appointed by the European Association of Nuclear Medicine (EANM), 3 radiologists and 3 clinicians (one diabetologist, one podiatrist and one infectious diseases specialist) selected for their expertise in diabetic foot...
March 27, 2024: European Journal of Nuclear Medicine and Molecular Imaging
https://read.qxmd.com/read/38530971/thorax-support-vest-to-prevent-sternal-wound-infections-in-cardiac-surgery-patients-a-systematic-review-and-meta-analysis
#12
JOURNAL ARTICLE
Tulio Caldonazo, Michele Dell'Aquila, Gianmarco Cancelli, Lamia Harik, Giovanni Soletti, Johannes Fischer, Hristo Kirov, Mohamed Rahouma, Mudathir Ibrahim, Michelle Demetres, Kevin R An, Leonard Girardi, Torsten Doenst, Mario Gaudino
OBJECTIVES: Midline sternotomy is the main surgical access for cardiac surgeries. The most prominent complication of sternotomy is sternal wound infection (SWI). The use of a thorax support vest (TSV) that limits thorax movement and ensures sternal stability has been suggested to prevent postoperative SWI. We performed a meta-analysis to evaluate differences in clinical outcomes with and without the use of TSV after cardiac surgery in randomized trials. METHODS: The primary outcome was deep SWI (DSWI)...
March 26, 2024: Interdiscip Cardiovasc Thorac Surg
https://read.qxmd.com/read/38524868/the-potential-of-sheep-in-preclinical-models-for-bone-infection-research-a-systematic-review
#13
REVIEW
Michael L C Beagan, Chris H Dreyer, Louise K Jensen, Henrik E Jensen, Thomas E Andersen, Soeren Overgaard, Ming Ding
BACKGROUND: Reliable animal models are critical for preclinical research and should closely mimic the disease. With respect to route of infection, pathogenic agent, disease progression, clinical signs, and histopathological changes. Sheep have similar bone micro- and macrostructure as well as comparable biomechanical characteristics to humans. Their use in bone research is established, however their use in bone infection research is limited. This systematic review will summarise the key features of the available bone infection models using sheep, providing a reference for further development, validation, and application...
March 2024: Journal of Orthopaedic Translation
https://read.qxmd.com/read/38524360/comparative-analysis-of-surgical-outcomes-in-children-with-type-3-and-type-4-lateral-physeal-condylar-humerus-fractures-in-china-closed-reduction-percutaneous-pinning-crpp-vs-open-reduction-internal-fixation-orif
#14
JOURNAL ARTICLE
Md Fahim Muntasir Islam Sojib, Yan Song Wang
BACKGROUND: Lateral physeal condylar humerus fractures in pediatric patients aged 1-13 rank as the second most common elbow injury, occurring with a frequency ranging from 5% to 16.8%. There exists an ongoing debate regarding the surgical management of these fractures. This study aims to evaluate the efficacy of Open Reduction and Internal Fixation (ORIF) and Closed Reduction and Percutaneous Pinning (CRPP) as suitable surgical treatments for displaced unstable fractures of the lateral condyle physeal humerus in children...
August 2024: Journal of Orthopaedics
https://read.qxmd.com/read/38524043/excision-of-invasive-squamous-cell-carcinoma-complicated-by-osteomyelitis-and-tobacco-use-a-case-report
#15
Harriet Kaye Austin, Gloria M Gamboa, Carlene Waters-Hollingsworth
Squamous cell carcinoma (SCC) is a common type of skin cancer that can be treated through surgical excision using Mohs micrographic surgery (MMS) which results in minimal scarring and low complications. Soft tissue defects as a result of MMS that are too large to be primarily closed can be repaired with secondary intention healing through the use of biologic prosthetics that promote dermal regeneration and tissue remodeling with high success rates. Other non-surgical treatment options include chemotherapy (topical or systemic), radiation, or immunotherapy for advanced skin cancers...
February 2024: Curēus
https://read.qxmd.com/read/38524028/a-rare-case-of-fungal-osteomyelitis-of-the-distal-tibia-in-a-pediatric-patient
#16
Syed Faisal Afaque, Udit Agrawal, Dilip K Shankhwar, Suresh Chand, Vikas Verma
Staphylococcus aureus infection is the most common cause of osteomyelitis. Over 100,000 fungal species have been described; only 150 are pathogenic to humans. These opportunistic infections frequently enter the body due to a decrease in host defense or through an invasive gateway, such as a dental extraction or skin discontinuity due to trauma. Symptoms and radiological examination often mimic those of other etiologies, which can lead to substantial delays in treatment. Our case is a 13-year-old healthy boy with no history of immune incompetency who presented to us with complaints of pain and swelling over his left ankle and leg with an on-and-off history of fever for 15 days...
February 2024: Curēus
https://read.qxmd.com/read/38522433/the-impact-of-inflammatory-biomarkers-on-amputation-rates-in-patients-with-diabetic-foot-ulcers
#17
JOURNAL ARTICLE
Yun Xu, Ruina Geng, Xiangyu Meng, Zhipeng Feng, Xu Wang, Guanying Zhang, Liwei Bai
Diabetic Foot Ulcers (DFUs) are a major complication of diabetes, often leading to amputation. Understanding the relationship between haematological inflammatory markers and the incidence of amputation in DFU patients with infectious complications is crucial for improving management and outcomes. This retrospective study, conducted from May 2020 to October 2022, involved 109 patients with DFUs, categorised into amputation (AM) and non-amputation (NAM) groups. Patients were evaluated for various factors, including demographic data, DFU duration, and blood parameters such as haemoglobin A1c (HbA1c), haemoglobin (Hb), albumin (ALB), white blood cell count (WBC), erythrocyte sedimentation rate (ESR), procalcitonin (PCT), C-reactive protein (CRP), platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR), and lymphocyte-to-monocyte ratio (LMR)...
April 2024: International Wound Journal
https://read.qxmd.com/read/38520367/surgical-management-of-diabetic-foot-burns-is-associated-with-poor-outcomes-a-systematic-review-and-meta-analysis
#18
JOURNAL ARTICLE
Brigette Cannata, Nicolas Malkoff, Deborah Choe, Artur Manasyan, Haig A Yenikomshian, T Justin Gillenwater
There is no consensus for the optimal management of diabetic foot burn injuries. Here, we systematically identify studies reporting on diabetic foot burns and evaluate outcomes among patients managed operatively versus non-operatively. PubMed, Embase, and Web of Science were searched. Screening was performed by independent reviewers. Primary research studies with English full texts published between 1980 to 2023 that discussed outcomes of foot burns in adults with diabetes were included and critically appraised using validated tools...
March 23, 2024: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://read.qxmd.com/read/38516544/management-and-outcomes-of-necrotizing-otitis-externa-a-retrospective-cohort-study-in-a-tertiary-referral-center
#19
JOURNAL ARTICLE
Eleonora G M Vosbeek, Louise V Straatman, Arthur J A T Braat, Bart de Keizer, Hans G X M Thomeer, Adriana L Smit
OBJECTIVES: Necrotizing otitis externa (NOE) is a rare infection of the ear that causes osteomyelitis. We aimed to evaluate treatment outcomes and the role of imaging in diagnosing and monitoring disease resolution in a single-center study of patients with NOE. METHODS: In this retrospective cohort study, patients with NOE who were diagnosed and treated in a tertiary otology center in Utrecht, The Netherlands, between January 1, 2013 and August 1, 2022, were included...
December 2023: Otol Neurotol Open
https://read.qxmd.com/read/38516171/a-review-on-gold-nanoparticles-as-an-innovative-therapeutic-cue-in-bone-tissue-engineering-prospects-and-future-clinical-applications
#20
JOURNAL ARTICLE
Dae Hyeok Yang, Haram Nah, Donghyun Lee, Sung Jun Min, Seulki Park, Sang-Hyun An, Jianxin Wang, Huining He, Kyu-Sun Choi, Wan-Kyu Ko, Jae Seo Lee, Il Keun Kwon, Sang Jin Lee, Dong Nyoung Heo
Bone damage is a complex orthopedic problem primarily caused by trauma, cancer, or bacterial infection of bone tissue. Clinical care management for bone damage remains a significant clinical challenge and there is a growing need for more advanced bone therapy options. Nanotechnology has been widely explored in the field of orthopedic therapy for the treatment of a severe bone disease. Among nanomaterials, gold nanoparticles (GNPs) along with other biomaterials are emerging as a new paradigm for treatment with excellent potential for bone tissue engineering and regenerative medicine applications...
June 2024: Materials today. Bio
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