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Cardiomyocytes and Sirt-3

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https://www.readbyqxmd.com/read/29849892/short-duration-swimming-exercise-after-myocardial-infarction-attenuates-cardiac-dysfunction-and-regulates-mitochondrial-quality-control-in-aged-mice
#1
Dajun Zhao, Yang Sun, Yanzhen Tan, Zhengbin Zhang, Zuoxu Hou, Chao Gao, Pan Feng, Xing Zhang, Wei Yi, Feng Gao
Background: Exercise benefits to cardiac rehabilitation (CR) following stable myocardial infarction (MI). The suitable exercise duration for aged patients with coronary heart disease (CHD) remains controversial, and the underlying molecular mechanism is still unclear. Methods and Results: 18-Month-old mice after stable MI were randomly submitted to different durations of exercise, including 15 and 60 min swimming training (ST) once per day, five times a week for 8 weeks...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29532856/sirt3-deficiency-exacerbates-p53-parkin%C3%A2-mediated-mitophagy-inhibition-and-promotes-mitochondrial-dysfunction-implication-for-aged-hearts
#2
Yan Li, Ying Ma, Liqiang Song, Lu Yu, Le Zhang, Yingmei Zhang, Yuan Xing, Yue Yin, Heng Ma
Mitochondrial dynamics have critical roles in aging, and their impairment represents a prominent risk factor for myocardial dysfunction. Mitochondrial deacetylase sirtuin (SIRT)3 contributes greatly to the prevention of redox stress and cell aging. The present study explored the role of SIRT3 on myocardium aging. Western blot analysis demonstrated that SIRT3 expression levels were significantly lower in the myocardia of aged mice compared with young mice. Immunoprecipitation and western blot assays indicated that the activity of mitochondrial manganese superoxide dismutase (MnSOD) and peroxisome proliferator‑activated receptor γ coactivator (PGC)‑1α was reduced in the aged heart...
June 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28503736/hydrogen-sulfide-pretreatment-improves-mitochondrial-function-in-myocardial-hypertrophy-via-a-sirt3-dependent-manner
#3
Guoliang Meng, Jieqiong Liu, Shangmin Liu, Qiuyi Song, Lulu Liu, Liping Xie, Yi Han, Yong Ji
BACKGROUND AND PURPOSE: Hydrogen sulfide (H2 S) is a gaseous signal molecule with antioxidative properties. Sirtuin 3 (SIRT3) is closely associated with mitochondrial function and oxidative stress. The study was to investigate whether and how H2 S improved myocardial hypertrophy via a SIRT3-dependent manner. EXPERIMENTAL APPROACH: Neonatal rat cardiomyocytes were pretreated with NaHS (50 μM) for 4 h followed by angiotensin II (Ang II, 100 nM) for 24 h. SIRT3 was silenced with siRNA technology...
April 2018: British Journal of Pharmacology
https://www.readbyqxmd.com/read/27634872/mitochondrial-aldehyde-dehydrogenase-obliterates-insulin-resistance-induced-cardiac-dysfunction-through-deacetylation-of-pgc-1%C3%AE
#4
Nan Hu, Jun Ren, Yingmei Zhang
Insulin resistance contributes to the high prevalence of type 2 diabetes mellitus, leading to cardiac anomalies. Emerging evidence depicts a pivotal role for mitochondrial injury in oxidative metabolism and insulin resistance. Mitochondrial aldehyde dehydrogenase (ALDH2) is one of metabolic enzymes detoxifying aldehydes although its role in insulin resistance remains elusive. This study was designed to evaluate the impact of ALDH2 overexpression on insulin resistance-induced myocardial damage and mechanisms involved with a focus on autophagy...
November 22, 2016: Oncotarget
https://www.readbyqxmd.com/read/26053177/resveratrol-upregulates-cardiac-sdf-1-in-mice-with-acute-myocardial-infarction-through-the-deacetylation-of-cardiac-p53
#5
Wang Hong, Shimosawa Tatsuo, Wang Shou-Dong, Zhang Qian, Hou Jian-Feng, Wang Jue, Jin Chen, Qian Hai-Yan, Yang Yue-Jin
AIMS: We previously demonstrated that resveratrol (RSV) administration causes cardiac stromal cell-derived factor (SDF)-1 upregulation and can enhance the mobilization of stem cells in mice with acute myocardial infarction (AMI). However, the upstream signal transduction involved in SDF-1 regulation in the setting of AMI and RSV administration remains unclear. Because RSV is a sirtuin 1 (SIRT1) activator and SIRT proteins act as deacetylases, we investigated the role of SIRT1 in SDF-1 upregulation and its subsequent effects...
2015: PloS One
https://www.readbyqxmd.com/read/25975092/high-dose-of-epigallocatechin-3-gallate-inhibits-proliferation-and-induces-apoptosis-of-h9c2-cardiomyocytes-through-down-regulation-of-sirt1
#6
Yi Cai, Li Zhao, Yuan Qin, Yanhuan He
BACKGROUND: Previous studies have suggested that high doses of (-)-epigallocatechin-3-gallate (EGCG) can induce toxicity in the liver, kidneys, and intestine. However, there have been no reports of myocardiotoxicity following treatment with EGCG. In this study, we investiged the proliferation and apoptosis of H9C2 cardiomyocytes treated with high dose of EGCG. METHODS: Cell proliferation was measured by CCK8 assay, cell apoptosis rate was evaluated by TUNEL assay, and the expression alterations of Sirtuin 1 (SIRT1) protein was detected by Western blotting...
January 2015: Die Pharmazie
https://www.readbyqxmd.com/read/25863291/nad-dependent-sirt1-deactivation-has-a-key-role-on-ischemia-reperfusion-induced-apoptosis
#7
Arianna Cattelan, Giulio Ceolotto, Sergio Bova, Mattia Albiero, Maniselvan Kuppusamy, Sara De Martin, Andrea Semplicini, Gian Paolo Fadini, Saula Vigili de Kreutzenberg, Angelo Avogaro
Ischemia-reperfusion (IR) leads to severe organ injury and dysfunction. Sirtuins (SIRTs) are a family of histone deacetylases (HDACs) that require nicotinamide adenine dinucleotide (NAD(+)) for the deacetylation reaction. SIRTs play a major role in counteracting cellular stress and apoptosis. This study aimed to investigate the mechanisms of heart protection against apoptosis by SIRTs and the molecular pathways involved in SIRTs regulation and function in a rat model of IR injury. Hearts of male Wistar-Kyoto rats were subjected to 30-min ischemia followed by reperfusion up to 6h...
July 2015: Vascular Pharmacology
https://www.readbyqxmd.com/read/25330674/-protection-of-hypothermic-preserved-isolated-rat-hearts-by-resveratrol-and-its-underlying-mechanism
#8
Wei-Ming Sun, Ming-Zhi Zheng, Lei Ying, Xiao-Ming Yu, Si-Wen Wu, Ying-Ying Chen, Yue-Liang Shen, Yang Wang
OBJECTIVE: To investigate whether resveratrol (RES) plays a protective role in hypothermic preserved isolated rat hearts and whether it is mediated by regulation of silent information regulator protein-1 (Sirt-1) expression. METHODS: The Langendorff model of isolated rat heart was used. After stored in different Celsior solution at 4 degrees C for 9 h, SD rat hearts were randomly divided into 7 groups: blank control group;9 h group (soley hypothermic preservation for 9 h); RES group (3, 10, 30 micromol/L RES treatment plus hypothermic preservation for 9 h ), niacinamide (NAM) group (40 micromol/L NAM added in Celsior solution plus hypothermic preservation for 9 h), RES + NAM group (30 micromol/L RES and 40 micromol/L NAM were added in Celsior solution plus hypothermic preservation for 9 h)...
July 2014: Chinese Journal of Applied Physiology
https://www.readbyqxmd.com/read/25148910/exercise-training-enhanced-sirt1-longevity-signaling-replaces-the-igf1-survival-pathway-to-attenuate-aging-induced-rat-heart-apoptosis
#9
Chao-Hung Lai, Tsung-Jung Ho, Wei-Wen Kuo, Cecilia-Hsuan Day, Pei-Ying Pai, Li-Chin Chung, Po-Hsiang Liao, Feng-Huei Lin, En-Ting Wu, Chih-Yang Huang
Cardiovascular disease is the second leading cause of death (9.1 %) in Taiwan. Heart function deteriorates with age at a rate of 1 % per year. As society ages, we must study the serious problem of cardiovascular disease. SIRT1 regulates important cellular processes, including anti-apoptosis, neuronal protection, cellular senescence, aging, and longevity. In our previous studies, rats with obesity, high blood pressure, and diabetes exhibiting slowed myocardial performance and induced cell apoptosis were reversed via sports training through IGF1 survival signaling compensation...
2014: Age (2005-)
https://www.readbyqxmd.com/read/24535021/short%C3%A2-term-calorie-restriction-activates-sirt1%C3%A2-4-and-%C3%A2-7-in-cardiomyocytes-in-vivo-and-in-vitro
#10
Wei Yu, Hui-Fen Zhou, Rui-Bo Lin, Yu-Cai Fu, Wei Wang
Calorie restriction (CR) has been shown to increase longevity and mitigate age‑associated diseases in various organisms. Numerous studies have identified that sirtuin 1 (SIRT1) is upregulated by CR. However, the expression of SIRT isoforms 2‑7 in response to CR in cardiomyocytes has yet to be elucidated. Therefore, the present study aimed to investigate the cellular localization and expression of SIRT1‑7 in cardiomyocytes. Twenty SD rats were fed either ad libitum (AL) or a CR diet (60% of AL) for three weeks...
April 2014: Molecular Medicine Reports
https://www.readbyqxmd.com/read/23201401/sirt3-protects-cardiomyocytes-from-oxidative-stress-mediated-cell-death-by-activating-nf-%C3%AE%C2%BAb
#11
Chun-Juan Chen, Yu-Cai Fu, Wei Yu, Wei Wang
Oxidative stress-mediated cell death in cardiomyocytes reportedly plays an important role in many cardiac pathologies. Our previous report demonstrated that mitochondrial SIRT3 plays an essential role in mediating cell survival in cardiac myocytes, and that resveratrol protects cardiomyocytes from oxidative stress-induced apoptosis by activating SIRT3. However, the exact mechanism by which SIRT3 prevents oxidative stress remains unknown. Here, we show that exposure of H9c2 cells to 50 μM H(2)O(2) for 6h caused a significant increase in cell death and the down-regulation of SIRT3...
January 11, 2013: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/19415680/effects-of-resveratrol-on-h-2-o-2-induced-apoptosis-and-expression-of-sirts-in-h9c2-cells
#12
Wei Yu, Yu-Cai Fu, Xiao-Hui Zhou, Chun-Juan Chen, Xin Wang, Rui-Bo Lin, Wei Wang
Resveratrol, a polyphenol found in fruits, has been demonstrated to activate Sir2. Though many studies have demonstrated that resveratrol can activate SIRT1, whether it has effect on other sirtuins (SIRT2-7) are unknown. The present study shows that exposure of H9c2 cells to 50 microM H(2)O(2) for 6 h caused a significant increase in apoptosis, as evaluated by TUNEL and flow cytometry (FCM), but pretreatment of resveratrol (20 microM) eliminated H(2)O(2)-induced apoptosis. Resveratrol also prevented H(2)O(2)-induced caspase-3 activation...
July 1, 2009: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/18710944/sirt3-is-a-stress-responsive-deacetylase-in-cardiomyocytes-that-protects-cells-from-stress-mediated-cell-death-by-deacetylation-of-ku70
#13
Nagalingam R Sundaresan, Sadhana A Samant, Vinodkumar B Pillai, Senthilkumar B Rajamohan, Mahesh P Gupta
There are seven SIRT isoforms in mammals, with diverse biological functions including gene regulation, metabolism, and apoptosis. Among them, SIRT3 is the only sirtuin whose increased expression has been shown to correlate with an extended life span in humans. In this study, we examined the role of SIRT3 in murine cardiomyocytes. We found that SIRT3 is a stress-responsive deacetylase and that its increased expression protects myocytes from genotoxic and oxidative stress-mediated cell death. We show that, like human SIRT3, mouse SIRT3 is expressed in two forms, a approximately 44-kDa long form and a approximately 28-kDa short form...
October 2008: Molecular and Cellular Biology
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