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https://www.readbyqxmd.com/read/29933410/identification-of-dna-methylation-prognostic-signature-of-acute-myelocytic-leukemia
#1
Haiguo Zhang, Guanli Song, Guanbo Song, Ruolei Li, Min Gao, Ling Ye, Chengfang Zhang
BACKGROUND: The aim of this study is to find the potential survival related DNA methylation signature capable of predicting survival time for acute myelocytic leukemia (AML) patients. METHODS: DNA methylation data were downloaded. DNA methylation signature was identified in the training group, and subsequently validated in an independent validation group. The overall survival of DNA methylation signature was performed. Functional analysis was used to explore the function of corresponding genes of DNA methylation signature...
2018: PloS One
https://www.readbyqxmd.com/read/29933406/anemia-modifies-the-prognostic-value-of-glycated-hemoglobin-in-patients-with-diabetic-chronic-kidney-disease
#2
I-Ching Kuo, Hugo You-Hsien Lin, Sheng-Wen Niu, Jia-Jung Lee, Yi-Wen Chiu, Chi-Chih Hung, Shang-Jyh Hwang, Hung-Chun Chen
A common complication of chronic kidney disease (CKD), anemia can influence glycated hemoglobin (HbA1c) levels. In diabetic patients, anemia occurs earlier and with higher severity over the course of CKD stages. To elucidate the effect of hemoglobin (Hb) on the predictive value of HbA1c, we enrolled 1558 diabetic patients with stages 3-4 CKD, categorized according to baseline Hb and HbA1c quartiles. Linear regression revealed that higher HbA1c correlated significantly with higher Hb in the Hb < 10 g/dL group (β = 0...
2018: PloS One
https://www.readbyqxmd.com/read/29933272/electroencephalographic-arousal-patterns-under-dexmedetomidine-sedation
#3
Jamie W Sleigh, Susana Vacas, Alana M Flexman, Pekka O Talke
BACKGROUND: The depth of dexmedetomidine-induced sedation is difficult to assess without arousing the patient. We evaluated frontal electroencephalogram (EEG) as an objective measure of dexmedetomidine-induced sedation. Our aims were to characterize the response patterns of EEG during a wide range of dexmedetomidine-induced sedation and to determine which spectral power best correlated with assessed levels of dexmedetomidine-induced sedation. METHODS: Sedline EEG sensor was positioned on the forehead of 16 volunteers...
June 20, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29933195/bioelectrical-impedance-analysis-a-new-method-to-evaluate-lymphoedema-fluid-status-and-tissue-damage-after-gynaecological-surgery-a-systematic-review
#4
REVIEW
Madeleine Asklöf, Preben Kjølhede, Ninnie Borendal Wodlin, Lena Nilsson
The aim of this descriptive review is to summarise the current knowledge of non-invasive bioelectrical impedance analysis (BIA) used with gynaecological surgical patients in regard to postoperative development of lymphoedema and determination of perioperative fluid balance, and as a prognostic factor in cancer mortality and a predictor of postoperative complications. The databases PubMed, MEDLINE, Scopus Web of Science, the Cochrane Library, and reference lists of selected articles were searched for relevant articles published during the period January 2008-April 2018...
June 18, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29933057/evidence-for-a-shared-representation-of-sequential-cues-that-engage-sign-tracking
#5
Elizabeth B Smedley, Kyle S Smith
Sign-tracking is a phenomenon whereby cues that predict rewards come to acquire their own motivational value (incentive salience) and attract appetitive behavior. Typically, sign-tracking paradigms have used single auditory, visual, or lever cues presented prior to a reward delivery. Yet, real world examples of events often can be predicted by a sequence of cues. We have shown that animals will sign-track to multiple cues presented in temporal sequence, and with time develop a bias in responding toward a reward distal cue over a reward proximal cue...
June 19, 2018: Behavioural Processes
https://www.readbyqxmd.com/read/29932945/regional-radiation-dose-response-modeling-of-functional-liver-in-hepatocellular-carcinoma-patients-with-longitudinal-sulfur-colloid-spect-ct-a-proof-of-concept
#6
Ryan G Price, Smith Apisarnthanarax, Stephanie K Schaub, Matthew J Nyflot, Tobias R Chapman, Manuela Matesan, Hubert J Vesselle, Stephen R Bowen
We report on patient-specific quantitative changes in longitudinal sulfur colloid SPECT/CT as a function of regional radiation dose distributions to normal liver in a cohort of hepatocellular carcinoma patients. Dose-response thresholds and slopes varied with baseline liver function metrics, and extreme values were found in patients with fatal hepatotoxicity. Dose-response modeling of normal liver in individual HCC patients has potential to characterize in vivo radiosensitivity, identify high risk subgroups, and personalize treatment planning dose constraints...
June 19, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29932892/can-copeptin-and-troponin-t-ratio-predict-final-infarct-size-and-myocardial-salvage-index-in-patients-with-st-elevation-myocardial-infarction-a-sub-study-of-the-danami-3-trial
#7
Ásthildur Árnadóttir, Mikkel Schoos, Jacob Lønborg, Kiril Ahtarovski, Henning Kelbæk, Steffen Helqvist, Dan Høfsten, Peter Clemmensen, Thomas Engstrøm, Lars Nepper-Christensen, Niels Vejlstrup, Lars Køber, Kasper Iversen
BACKGROUND: Primary percutaneous coronary intervention (pPCI) is recommended in patients presenting with ST-elevation myocardial infarction (STEMI) within <12 h of symptom onset. However, patients-reported symptom duration is not always reliable. Cardiac specific troponin T (cTnT) and the endogenous stress marker copeptin have different temporal release patterns for myocardial infarction MI. We hypothesized that copeptin/troponin-ratio is associated to the duration of coronary occlusion and therefore inversely proportional to myocardial salvage...
June 19, 2018: Clinical Biochemistry
https://www.readbyqxmd.com/read/29932858/not-all-ductal-carcinomas-in-situ-are-created-idle-indolent-lesions-of-epithelial-origin
#8
Melissa Alexander, Jessica Beyda, Anupma Nayak, Shabnam Jaffer
CONTEXT: - Mammographic screening has increased the incidence of ductal carcinoma in situ (DCIS), but this has not been accompanied by a decline in the incidence of invasive carcinoma (IC). Consequently, the surgical treatment of DCIS has recently been questioned, with some advocating only surveillance (with or without neoadjuvant endocrine therapy) after a core biopsy diagnosis of DCIS. OBJECTIVES: - To examine the predictive value of a core biopsy diagnosis of DCIS, particularly the upgrade rate to IC, and to identify associated factors...
June 22, 2018: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/29932840/identification-and-characterization-of-candidates-involved-in-production-of-omegas-in-microalgae-a-gene-mining-and-phylogenomic-approach
#9
Vikas U Kapase, Asha A Nesamma, Pannaga P Jutur
Optimizing the production of the high-value renewables such as OMEGAs through pathway engineering requires an in-depth understanding of the structure-function relationship of genes involved in the OMEGA biosynthetic pathways. In this preliminary study, our rationale is to identify and characterize the ∼221 putative genes involved in production of OMEGAs using bioinformatic analysis from the Streptophyte (plants), Chlorophyte (green algae), Rhodophyta (red algae), and Bacillariophyta (diatoms) lineages based on their phylogenomic profiling, conserved motif/domain organization and physico-chemical properties...
June 22, 2018: Preparative Biochemistry & Biotechnology
https://www.readbyqxmd.com/read/29932827/early-gender-differences-in-core-values-predict-anticipated-family-versus-career-orientation
#10
Katharina Block, Antonya Marie Gonzalez, Toni Schmader, Andrew Scott Baron
Communion and agency are often described as core human values. In adults, these values predict gendered role preferences. Yet little work has examined the extent to which young boys and girls explicitly endorse communal and agentic values and whether early gender differences in values predict boys' and girls' different role expectations. In a sample of 411 children between the ages of 6 and 14 years, we found consistent gender differences in endorsement of communal and agentic values. Across this age range, boys endorsed communal values less and agentic values more than did girls...
June 1, 2018: Psychological Science
https://www.readbyqxmd.com/read/29932682/precision-mass-measurements-of-58-63-cr-nuclear-collectivity-towards-the-n-40-island-of-inversion
#11
M Mougeot, D Atanasov, K Blaum, K Chrysalidis, T Day Goodacre, D Fedorov, V Fedosseev, S George, F Herfurth, J D Holt, D Lunney, V Manea, B Marsh, D Neidherr, M Rosenbusch, S Rothe, L Schweikhard, A Schwenk, C Seiffert, J Simonis, S R Stroberg, A Welker, F Wienholtz, R N Wolf, K Zuber
The neutron-rich isotopes ^{58-63}Cr were produced for the first time at the ISOLDE facility and their masses were measured with the ISOLTRAP spectrometer. The new values are up to 300 times more precise than those in the literature and indicate significantly different nuclear structure from the new mass-surface trend. A gradual onset of deformation is found in this proton and neutron midshell region, which is a gateway to the second island of inversion around N=40. In addition to comparisons with density-functional theory and large-scale shell-model calculations, we present predictions from the valence-space formulation of the ab initio in-medium similarity renormalization group, the first such results for open-shell chromium isotopes...
June 8, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/29932430/dynamic-data-monitoring-improves-predictive-analytics-for-failed-extubation-in-the-icu
#12
Jessica Keim-Malpass, Kyle B Enfield, James Forrest Calland, Douglas E Lake, Matthew T Clark
Predictive analytics monitoring that informs clinicians of the risk for failed extubation would help minimize both the duration of mechanical ventilation and the risk of emergency re-intubation in ICU patients. We hypothesized that dynamic monitoring of cardiorespiratory data, vital signs, and lab test results would add information to standard clinical risk factors. To develop predictive analytic models for patients who failed extubation in critical care settings in an academic medical center using standard and novel risk factors...
June 22, 2018: Physiological Measurement
https://www.readbyqxmd.com/read/29932401/can-multiphase-ct-scan-distinguish-between-papillary-renal-cell-carcinoma-type-1-and-type-2
#13
Ahmet Bindayi, Michelle L Mcdonald, Alp T Beksac, Gerant Rivera-Sanfeliz, Ahmed Shabaik, Fiona Hughes, Lejla Aganovic, Donna E Hansel, Ithaar H Derweesh
OBJECTIVE: To investigate the utility of multiphase computed tomography (CT) and percutaneous renal mass biopsy (PRMB) in differentiating between papillary renal cell carcinoma (pRCC)-Type 1 and -Type 2, as emerging data have suggested differential enhancement patterns in different renal tumor histologies. MATERIAL AND METHODS: Retrospective analysis of 51 patients (23 pRCC-Type 1/28 pRCC-Type 2) who underwent multiphase CT followed by surgery from July 2011 to April 2016 was performed...
July 2018: Turkish Journal of Urology
https://www.readbyqxmd.com/read/29932266/eanm-ean-recommendations-for-the-use-of-brain-18-f-fluorodeoxyglucose-positron-emission-tomography-fdg-pet-in-neurodegenerative-cognitive-impairment-and-dementia-delphi-consensus
#14
Flavio Nobili, Javier Arbizu, Femke Bouwman, Alexander Drzezga, Federica Agosta, Peter Nestor, Zuzana Walker, Marina Boccardi
BACKGROUND: Recommendations for using FDG-PET to support the diagnosis of dementing neurodegenerative disorders are sparse and poorly structured. METHODS: We defined 21 questions on diagnostic issues and on semi-automated analysis to assist visual reading. Literature was reviewed to assess study design, risk of bias, inconsistency, imprecision, indirectness and effect size. Critical outcomes were sensitivity, specificity, accuracy, positive/negative predictive value, area under the receiving operating characteristic curve, and positive/negative likelihood ratio of FDG-PET in detecting the target conditions...
June 22, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29932100/in-silico-docking-and-in-vitro-approaches-towards-bace1-and-cholinesterases-inhibitory-effect-of-citrus-flavanones
#15
Seungeun Lee, Kumju Youn, GyuTae Lim, Jinhyuk Lee, Mira Jun
Alzheimer&rsquo;s disease (AD) is the most prevalent neurodegenerative disease, distinctively characterized by senile plaques, neurofibrillary tangles, and synaptic loss, finally resulting in neuronal death. &beta;-Site amyloid precursor protein (APP) cleaving enzyme 1 (BACE1) and cholinesterases have been identified as therapeutic targets for AD, and the discovery of their inhibitors is of critical importance for developing preventive strategies for AD. To discover natural multi-target compounds possessing BACE1, acetylcholinesterase (AChE), and butyrylcholinesterase (BChE) inhibitory properties, major citrus flavanones including hesperetin, naringenin, and hesperidin were evaluated...
June 22, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29931785/optimisation-of-the-medium-for-the-growth-of-nitrobacter-winogradskyi-by-statistical-method
#16
Yun Zhang, Yang Zhang, Jie Gao, Qiuxuan Shen, Zhihui Bai, Xuliang Zhuang, Guoqiang Zhuang
Although Nitrobacter winogradskyi is an important chemoorganotrophic organism for the study of nitrite-oxidizing bacteria (NOB) physiology as well as nitrification, until now, the mixotrophic medium for this organism growth has not been optimized, comprehensively. In this study, we aimed to improve the growth medium of N. winogradskyi using the one-factor-at-a-time (NaNO2 , glycerol, pH) method. In addition, a further experimental design was carried out based on Central Composite Design (CCD) with response surface methodology (RSM)...
June 21, 2018: Letters in Applied Microbiology
https://www.readbyqxmd.com/read/29931725/use-of-positive-contrast-radiography-to-identify-synovial-involvement-in-horses-with-traumatic-limb-wounds
#17
H A Bryant, J J Dixon, R Weller, D M Bolt
BACKGROUND: The diagnostic value of positive contrast radiography in the work-up of suspected synovial infection in horses with limb wounds near synovial structures has yet to be systematically evaluated. OBJECTIVES: To determine the specificity, sensitivity and positive and negative predictive values of positive contrast radiography for identification of synovial infection in a population of horses with limb wounds. STUDY DESIGN: Retrospective case study comparing the performance of positive contrast radiography to the gold standard of synovial fluid cytology in horses presenting with limb wounds in the vicinity of synovial structures...
June 21, 2018: Equine Veterinary Journal
https://www.readbyqxmd.com/read/29931641/direct-and-indirect-photolysis-of-the-antibiotic-enoxacin-kinetics-of-oxidation-by-reactive-photo-induced-species-and-simulations
#18
Arlen Mabel Lastre-Acosta, Bruna Barberato, Marcela Prado Silva Parizi, Antonio Carlos Silva Costa Teixeira
The purpose of this study was to investigate the aqueous phase photochemical behavior of enoxacin (ENO), an antibiotic selected as a model pollutant of emerging concern. The second-order reaction rate constants of ENO with hydroxyl radicals (HO● ) and singlet oxygen (1 O2 ) were determined at pH 3, 7, and 9. Also, the rate constants of the electron transfer reaction between ENO and triplet states of chromophoric dissolved organic matter (3 CDOM*) are reported for the first time, based on anthraquinone-2-sulfonate (AQ2S) as CDOM proxy...
June 21, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29931633/prediction-and-optimization-of-ci-engine-performance-fuelled-with-calophyllum-inophyllum-diesel-blend-using-response-surface-methodology-rsm
#19
Paramaguru Venugopal, Ramesh Kasimani, Suresh Chinnasamy
The transportation demand in India is increasing tremendously, which arouses the energy consumption by 4.1 to 6.1% increases each year from 2010 to 2050. In addition, the private vehicle ownership keeps on increasing almost 10% per year during the last decade and reaches 213 million tons of oil consumption in 2016. Thus, this makes India the third largest importer of crude oil in the world. Because of this problem, there is a need of promoting the alternative fuels (biodiesel) which are from different feedstocks for the transportation...
June 21, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29931570/comparison-of-preoperative-and-postoperative-measurements-of-optical-low-coherence-reflectometry-biometry-and-assessment-of-its-refractive-predictability
#20
İrfan Akalın, Melek Tüfek, Mustafa Türkyılmaz, Faruk Öztürk
PURPOSE: To compare the preoperative and postoperative measurements of optical low-coherence reflectometry (OLCR) biometry and assessment of its refractive predictability. METHODS: A total of 114 eyes of 102 patients who underwent cataract treatment were prospectively examined. The axial length (AL), central corneal thickness (CCT), anterior chamber depth (ACD), lens thickness (LT), K (keratometry) 1, K2, K average (KAVE) and K astigmatic (KAST) values were recorded using Lenstar LS 900 (Haag-Streit, Koeniz, Switzerland) OLCR device...
June 21, 2018: International Ophthalmology
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