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https://www.readbyqxmd.com/read/29684683/brain-related-proteins-as-potential-csf-biomarkers-of-alzheimer-s-disease-a-targeted-mass-spectrometry-approach
#1
Ilijana Begcevic, Davor Brinc, Marshall Brown, Eduardo Martinez-Morillo, Oliver Goldhardt, Timo Grimmer, Viktor Magdolen, Ihor Batruch, Eleftherios P Diamandis
Alzheimer's disease (AD) is the most common cause of dementia, characterized by progressive cognitive decline. The main disease hallmarks include amyloid beta aggregates and neurofibrillary tangles. Brain pathology is reflected in cerebrospinal fluid (CSF); the core biomarkers amyloid beta 1-42, total and phosphorylated tau protein levels are changed, relative to cognitively normal elderly. Still, there is a need for additional biomarkers which could identify disease more accurately and at an earlier stage, predict severity and be used in research settings...
April 20, 2018: Journal of Proteomics
https://www.readbyqxmd.com/read/29684670/evaluation-of-the-bisap-scoring-system-in-prognostication-of-acute-pancreatitis-a-prospective-observational-study
#2
Sumitra Hagjer, Nitesh Kumar
INTRODUCTION: Severe acute pancreatitis has a high mortality and its early identification is important for management and risk stratification. The bedside index for severity in acute pancreatitis (BISAP) is a simple scoring system done at admission which predicts the severity of pancreatitis. Procalcitonin is an inflammatory marker which is raised very early and helps in early prediction of the severity of disease. This study aims to evaluate the BISAP score and Procalcitonin in prognostication of acute pancreatitis...
April 20, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29684513/adult-chiari-i-malformations-an-analysis-of-surgical-risk-factors-and-complications-using-an-international-database
#3
Abhiraj D Bhimani, Darian R Esfahani, Steven Denyer, Ryan G Chiu, David Rosenberg, Ashley L Barks, Gregory D Arnone, Ankit I Mehta
BACKGROUND: Chiari I malformations are common in adults, and a frequent procedure in neurosurgical practice. Despite a number of studies, to date there is no consensus about the indications or surgical technique for this common condition. Growing emphasis on value-based care has emphasized reduction of readmissions and reoperations, and is particularly relevant in Chiari, which has traditionally been associated with a high complication rate. OBJECTIVE: To provide a contemporary surgical profile of risk factors and complications for Chiari I malformations in adults...
April 20, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29684484/characterization-of-long-non-coding-rnas-to-reveal-potential-prognostic-biomarkers-in-hepatocellular-carcinoma
#4
REVIEW
Yijie Ma, Tong Luo, Dong Dong, Xubo Wu, Yilin Wang
Dysregulation of long non-coding RNAs (lncRNAs) plays critical roles in a variety of biological processes. Recent studies have documented that lncRNAs can function as potential biomarkers in cancer prognosis, however, little is known in hepatocellular carcinoma (HCC). To identify lncRNA signatures that have prognostic values in HCC, we analyzed lncRNA expression profiles of 364 HCC patients from The Cancer Genome Atlas (TCGA) dataset. A set of four lncRNAs was identified to be significantly associated with the overall survival...
April 20, 2018: Gene
https://www.readbyqxmd.com/read/29684407/modelling-singular-perturbation-and-bifurcation-analyses-of-bitrophic-food-chains
#5
B W Kooi, J C Poggiale
Two predator-prey model formulations are studied: for the classical Rosenzweig-MacArthur (RM) model and the Mass Balance (MB) chemostat model. When the growth and loss rate of the predator is much smaller than that of the prey these models are slow-fast systems leading mathematically to singular perturbation problem. In contradiction to the RM-model, the resource for the prey are modelled explicitly in the MB-model but this comes with additional parameters. These parameter values are chosen such that the two models become easy to compare...
April 20, 2018: Mathematical Biosciences
https://www.readbyqxmd.com/read/29684383/prognostic-role-of-haematological-indices-in-sudden-sensorineural-hearing-loss-review-and-meta-analysis
#6
REVIEW
Zaizai Cao, Ziyue Li, Haijie Xiang, Saiyu Huang, Jinjian Gao, Xiang Zhan, Xiuxiu Zhen, Bangliang Li, JianBin Wu, Bobei Chen
BACKGROUND: Complete blood count (CBC) is an important blood test in clinical practice, and it has been recently used to predict the prognosis of patients with sudden sensorineural hearing loss (SSNHL). Some haematological indices of the CBC test have been reported to be associated with the clinical outcome of SSNHL. However, the prognostic value of these haematological indices in SSNHL is currently under debate. Here, we performed a meta-analysis to investigate the association between haematological indices of the CBC test and clinical outcomes in patients with SSNHL...
April 20, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29684381/serum-chloride-as-a-novel-marker-for-adding-prognostic-information-of-mortality-in-chronic-heart-failure
#7
Yang Zhang, Rui Peng, Xinqiang Li, Jinxing Yu, Xi Chen, Zhou Zhou
BACKGROUND: Serum chloride concentrations have clinical significance in the prognosis of heart failure (HF). Little is known regarding the prognostic value of serum chloride in patients with chronic heart failure (CHF). This study sought to investigate the prognostic ability of admission serum chloride for long-term mortality in CHF patients. METHODS: We recruited 1021 patients diagnosed with CHF. Participants were followed up for all-cause mortality at 21 ± 9 months to establish the survival models and analyze the association between admission serum chloride concentrations and death risk...
April 20, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29684375/cumulative-effect-of-preoperative-risk-factors-on-mortality-after-pediatric-heart-transplantation
#8
Matthew J O'Connor, Andrew C Glatz, Joseph W Rossano, Robert E Shaddy, Rachel Ryan, Chitra Ravishankar, Stephanie Fuller, Christopher E Mascio, J William Gaynor, Kimberly Y Lin
BACKGROUND: Risk assessment in heart transplantation is critical for candidate selection, but current models inadequately assess individual risk of postoperative mortality. We sought to identify risk factors and develop a scoring system to predict mortality following heart transplantation in children. METHODS: The records of patients undergoing heart transplantation at our institution from 2010 - 2016 were reviewed. Clinical characteristics were recorded and compared between survivors and non-survivors...
April 20, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29684318/does-size-matter-when-calculating-the-correct-tidal-volume-for-pediatric-mechanical-ventilation-a-hypothesis-based-on-forced-vital-capacity
#9
Gina J Kim, Christopher J L Newth, Robinder G Khemani, Suzy L Wong, Allan L Coates, Patrick A Ross
BACKGROUND: Tidal volumes standardized to predicted body weight are recommended for adult mechanical ventilation, but children are frequently ventilated using measured body weight. Our goal is to examine the difference in forced vital capacity (FVC ml/kg) using measured compared to predicted body weight in children. METHODS: Retrospective analysis of outpatient pulmonary function tests (PFTs) from two datasets. Dataset one: 6 to 19 year old children undergoing PFTs from the nationally-representative Canadian Health Measures Survey...
April 20, 2018: Chest
https://www.readbyqxmd.com/read/29684291/short-term-prediction-of-coronary-heart-disease-mortality-in-the-czech-republic-based-on-data-from-1968-2014
#10
Jindra Reissigová, Miroslav Zvolský
OBJECTIVES: The aim was to explore the patterns of the coronary heart disease (CHD) mortality rates over the past almost 50 years (1968-2014) in the Czech Republic, and to predict the mortality rates in 2015-2019. METHODS: The number of deaths from CHD and the population size were stratified by sex and age. The mortality rates were age-standardized to European population. Their values in 2015-2019 were estimated using the joinpoint log-linear regression, local log-linear regression and negative binomial log-linear regression, separately for males and females...
March 2018: Central European Journal of Public Health
https://www.readbyqxmd.com/read/29684288/endobronchial-ultrasound-for-nodal-staging-of-non-small-cell-lung-cancer-patients-with-radiologically-normal-mediastinum-a-meta-analysis
#11
Hazem El-Osta, Pushan Jani, Ali Mansour, Philip Rascoe, Syed Jafri
RATIONALE: An accurate assessment of the mediastinal lymph nodes status is essential in the staging and treatment planning of potentially resectable non-small cell lung cancer (NSCLC). OBJECTIVES: We performed this meta-analysis to evaluate the role of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) in detecting occult mediastinal disease in NSCLC with no radiologic mediastinal involvement. METHODS: The PubMed, Embase, and Cochrane libraries were searched for studies describing the role of EBUS-TBNA in lung cancer patients with radiologically negative mediastinum...
April 23, 2018: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29684277/immunopet-imaging-of-endogenous-and-transfected-prolactin-receptor-tumor-xenografts
#12
Sarah M Cheal, Shutian Ruan, Darren R Veach, Valerie A Longo, Blesida J Punzalan, Jiong Wu, Edward K Fung, Marcus P Kelly, Jessica R Kirshner, Jason T Giurleo, George Ehrlich, Amy Q Han, Gavin Thurston, William C Olson, Pat B Zanzonico, Steven M Larson, Jorge A Carrasquillo
OBJECTIVE: Antibodies labeled with positron-emitting isotopes have been used for tumor detection, predicting which patients may respond to tumor antigen-directed therapy, and assessing pharmacodynamic effects of drug interventions. Prolactin receptor (PRLR) is overexpressed in breast and prostate cancers and is a new target for cancer therapy. We evaluated REGN2878, an anti-PRLR monoclonal antibody, as an immunoPET reagent. METHODS: REGN2878 was labeled with Zr-89 after conjugation with desferrioxamine B or labeled with I-131/I-124...
April 23, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29684255/molecular-profiling-of-post-reperfusion-milieu-determines-acute-kidney-injury-after-liver-transplantation-a-prospective-study
#13
Carlo Pulitano, Phong Ho, Deborah Verran, Charbel Sandroussi, David Joseph, David G Bowen, Geoffrey W McCaughan, Michael Crawford, Nicholas Shackel
Acute kidney injury (AKI) after liver transplantation (LT) is a common event, but its pathogenesis remains unclear. The aim of this prospective study is to investigate the potential relationship between post-reperfusion gene expression, serum mediators, and the onset of AKI after LT. Sixty-five consecutive patients undergoing LT were included in the study. Reverse transcription polymerase chain reaction (RT- PCR), was performed on liver biopsies. Gene expression of 23 genes involved in ischemia reperfusion injury (IRI) was evaluated...
April 23, 2018: Liver Transplantation
https://www.readbyqxmd.com/read/29684252/index-of-healthy-aging-in-chinese-older-adults-china-health-and-retirement-longitudinal-study
#14
Chenkai Wu, Anne B Newman, Bi-Rong Dong, Michelle C Odden
OBJECTIVES: To characterize the distribution of an index of healthy aging-the Chinese Healthy Aging Index (CHAI)-in Chinese adults aged 60 and older according to sociodemographic characteristics and geographic region and to examine the association between the CHAI and mortality, disability, and functional limitation over 4 years. DESIGN: Nationally representative cohort study. SETTING: China Health and Retirement Longitudinal Study. PARTICIPANTS: Chinese adults aged 60 and older (N=3,740)...
April 23, 2018: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29684178/the-network-structure-of-schizotypal-personality-traits
#15
Eduardo Fonseca-Pedrero, Javier Ortuño, Martin Debbané, Raymond C K Chan, David Cicero, Lisa C Zhang, Colleen Brenner, Emma Barkus, Richard J Linscott, Thomas Kwapil, Neus Barrantes-Vidal, Alex Cohen, Adrian Raine, Michael T Compton, Erin B Tone, Julie Suhr, Felix Inchausti, Julio Bobes, Axit Fumero, Stella Giakoumaki, Ioannis Tsaousis, Antonio Preti, Michael Chmielewski, Julien Laloyaux, Anwar Mechri, Mohamed Aymen Lahmar, Viviana Wuthrich, Frank Larøi, Johanna C Badcock, Assen Jablensky, Adela M Isvoranu, Sacha Epskamp, Eiko I Fried
Elucidating schizotypal traits is important if we are to understand the various manifestations of psychosis spectrum liability and to reliably identify individuals at high risk for psychosis. The present study examined the network structures of (1) 9 schizotypal personality domains and (2) 74 individual schizotypal items, and (3) explored whether networks differed across gender and culture (North America vs China). The study was conducted in a sample of 27001 participants from 12 countries and 21 sites (M age = 22...
April 19, 2018: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/29684041/public-perceptions-about-climate-change-mitigation-in-british-columbia-s-forest-sector
#16
Guillaume Peterson St-Laurent, Shannon Hagerman, Robert Kozak, George Hoberg
The role of forest management in mitigating climate change is a central concern for the Canadian province of British Columbia. The successful implementation of forest management activities to achieve climate change mitigation in British Columbia will be strongly influenced by public support or opposition. While we now have increasingly clear ideas of the management opportunities associated with forest mitigation and some insight into public support for climate change mitigation in the context of sustainable forest management, very little is known with respect to the levels and basis of public support for potential forest management strategies to mitigate climate change...
2018: PloS One
https://www.readbyqxmd.com/read/29683980/evaluation-of-serum-procollagen-c-proteinase-enhancer-1-level-as-a-fibrosis-marker-in-patients-with-chronic-hepatitis-b
#17
Onur Gokce, Seren Ozenirler, Aysegul Atak Yucel, Nihan Oruklu, Guldal Yilmaz Esendagli, Sevilay Karahan
AIM: Although liver biopsy has long been considered the gold standard for staging fibrosis, because of the disadvantages and risks of biopsy, several noninvasive processes such as serum biomarkers have been introduced for the assessment of liver fibrosis. The aim of this study was to assess the diagnostic value of serum procollagen C-proteinase enhancer 1 (PCPE-1) as a noninvasive fibrosis marker in treatment-naive chronic hepatitis B patients. PATIENTS AND METHODS: This study included 126 patients with biopsy-proven hepatitis B and 50 healthy controls...
April 20, 2018: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29683918/detection-of-persisting-concussion-effects-on-neuromechanical-responsiveness
#18
Gary B Wilkerson, Dustin C Nabhan, Chad J Prusmack, William J Moreau
PURPOSE: Assessment of various indices of neuromechanical responsiveness for association with concussion history. METHODS: An observational cohort study included 48 elite athletes (34 males: 23.8 ±4.4 years; 14 females: 25.4 ±4.5 years) who performed visuomotor reaction time (VMRT) tests involving rapid manual contact with illuminated target buttons that included 2 dual-task conditions: 1) simultaneous oral recitation of scrolling text (VMRT+ST) and 2) simultaneous verbal responses to identify the right or left direction indicated by the center arrow of the Eriksen flanker test (VMRT+FT)...
April 21, 2018: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29683909/acog-committee-opinion-no-734-the-role-of-transvaginal-ultrasonography-in-evaluating-the-endometrium-of-women-with-postmenopausal-bleeding
#19
(no author information available yet)
Cancer of the endometrium is the most common type of gynecologic cancer in the United States. Vaginal bleeding is the presenting sign in more than 90% of postmenopausal women with endometrial carcinoma. Clinical risk factors for endometrial cancer, including but not limited to age, obesity, use of unopposed estrogen, specific medical comorbidities (eg, polycystic ovary syndrome, type 2 diabetes mellitus, atypical glandular cells on screening cervical cytology), and family history of gynecologic malignancy also should be considered when evaluating postmenopausal bleeding...
May 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29683904/acog-committee-opinion-no-734-summary-the-role-of-transvaginal-ultrasonography-in-evaluating-the-endometrium-of-women-with-postmenopausal-bleeding
#20
(no author information available yet)
Cancer of the endometrium is the most common type of gynecologic cancer in the United States. Vaginal bleeding is the presenting sign in more than 90% of postmenopausal women with endometrial carcinoma. Clinical risk factors for endometrial cancer, including but not limited to age, obesity, use of unopposed estrogen, specific medical comorbidities (eg, polycystic ovary syndrome, type 2 diabetes mellitus, atypical glandular cells on screening cervical cytology), and family history of gynecologic malignancy also should be considered when evaluating postmenopausal bleeding...
May 2018: Obstetrics and Gynecology
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