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Jorrit B A Welling, Jorine E Hartman, Nick H T Ten Hacken, Ina Franz, Jean-Paul Charbonnier, Eva M van Rikxoort, Huib A M Kerstjens, Karin Klooster, Dirk-Jan Slebos
BACKGROUND: Absence of interlobar collateral ventilation using the Chartis measurement is the key predictor for successful endobronchial valve treatment in severe emphysema. Chartis was originally validated in spontaneous breathing patients under conscious sedation (CS); however, this can be challenging due to cough, mucus secretion, mucosal swelling, and bronchoconstriction. Performing Chartis under general anesthesia (GA) avoids these problems and may result in an easier procedure with a higher success rate...
August 16, 2018: Respiration; International Review of Thoracic Diseases
Dijiong Wu, Keding Shao, Qihao Zhou, Jie Sun, Ziqi Wang, Fei Yan, Tingting Liu, Xiangping Wu, Baodong Ye, He Huang, Yuhong Zhou
BACKGROUND/AIMS: Although the cure rate of acute promyelocytic leukemia (APL) has exceeded 90%, the relapse/refractory APL that resistant to all-trans retinoic acid (ATRA) or ATO was still serious concern. Matrine (MAT) could improve the differentiation ability of ATRA-resistant APL cells. This study aimed to explore how the APL-specific fusion protein was degraded in ATRA-resistant APL with the application of MAT and ATRA. METHODS: ATRA-sensitive (NB4) and ATRA-resistant (NB4-LR1) cell lines were used...
August 16, 2018: Cellular Physiology and Biochemistry
F Masi, A Rizzo, R Bresciani, N Martinuzzi, S D Wallace, D Van Oirschot, F Macor, T Rossini, R Fornaroli, V Mezzanotte
Treatment wetlands (TWs) have shown good capacity in dye removal from textile wastewater. However, the high hydraulic retention times (HRTs) required by these solutions and the connected high area requirements, remain a big drawback towards the application of TWs for dye treatment at full scale. Aerated TWs are interesting intensified solutions that attempt to reduce the TW required area. Therefore, an aerated CW pilot plant, composed of a 20 m2 horizontal subsurface flow TW (HF) and a 21 m2 Free Water System (FWS), equipped with aeration pipelines, was built and monitored to investigate the potential reduction of required area for dye removal from the effluent wastewater of a centralized wastewater treatment plant (WWTP)...
August 10, 2018: Science of the Total Environment
Saumaya Kirti, Vinay M Bhandari, Jyotsnarani Jena, Arnab S Bhattacharyya
In the present study, two synthesis methods of nanocomposites-one involving a mixture of biomass and the other using chemical modification were investigated to evaluate practical application of green approach in pollution control, specifically for water and wastewater treatment. Newer multifunctional superparamagnetic nanocomposites using biomaterials such as unripened fruit of Cassia fistula (Golden shower) and Aloe vera were developed as an example of green approach while chemical modification was illustrated using n-octanol...
August 13, 2018: Journal of Environmental Management
Ju Shen, Guohe Huang, Chunjiang An, Pei Song, Xiaying Xin, Yao Yao, Rubing Zheng
Multi-soil-layering (MSL) system was developed as an attractive alternative to traditional land-based treatment techniques. Within MSL system, the environmental cleanup capability of soil is maximized, while the soil microbial communities may also change during operation. This study aimed to reveal the nature of biophysiological changes in MSL systems during operation. The species diversity in soil mixture blocks was analyzed using Illumina HiSeq sequencing of the 16S rRNA gene. The interactive effects of operating factors on species richness, community diversity and bacteria abundance correlated with COD, N and P removal were revealed through factorial analysis...
August 13, 2018: Journal of Environmental Management
Elaine L Hill
This research exploits the introduction of shale gas wells in Pennsylvania in response to growing controversy around the drilling method of hydraulic fracturing. Using detailed location data on maternal addresses and GIS coordinates of gas wells, this study examines singleton births to mothers residing close to a shale gas well from 2003 to 2010 in Pennsylvania. The introduction of drilling increased low birth weight and decreased term birth weight on average among mothers living within 2.5 km of a well compared to mothers living within 2...
August 13, 2018: Journal of Health Economics
Christopher M Whaley, Timothy T Brown
This paper examines how health care providers respond to a reference pricing insurance program that increases consumer cost sharing when consumers choose high-priced surgical providers. We use geographic variation in the population covered by the program to estimate supply-side responses. We find limited evidence of market segmentation and price reductions for providers with baseline prices above the reference price. Finally, approximately 75% of the reduction in provider prices is in the form of a positive externality that benefits a population not subject to the program...
July 26, 2018: Journal of Health Economics
Achyut Adhikari, Veerachandra K Yemmireddy, Michael J Costello, Peter M Gray, Russ Salvadalena, Barbara Rasco, Karen Killinger
The effect of storage temperature and time on the viability of several foodborne bacterial pathogens inoculated into vacuum-packed canned pasteurized cow's milk cheese was investigated. Three popular cheese styles namely, a semi-soft white Monterey Jack style cheese, and two Cheddar cheeses vacuum packaged in mason jars were inoculated with a 3-strain cocktail of each of the following microbes at the mean concentrations listed: Escherichia coli O157:H7 (6.6 log CFU/g), Salmonella spp. (6.3 log CFU/g), Listeria innocua (6...
July 25, 2018: International Journal of Food Microbiology
Xiaoxiang Cheng, Daoji Wu, Heng Liang, Xuewu Zhu, Xiaobin Tang, Zhendong Gan, Jiajian Xing, Xinsheng Luo, Guibai Li
Algal extracellular organic matter (EOM) released from Microcystis aeruginosa can cause severe membrane fouling during algae-laden water treatment. To solve this problem, three typical sulfate radical-based advanced oxidation processes (SR-AOPs), i.e., ferrous iron/peroxymonosulfate (Fe(II)/PMS), UV/PMS and UV/Fe(II)/PMS, were employed as membrane pretreatment strategies. Their performance on mitigating EOM fouling of a ceramic UF membrane was systematically investigated and compared in the present study. The results indicated that SR-AOPs pretreatments could promote the reduction of DOC and UV254 , and the removal performance showed an apparent regularity of UV/Fe(II)/PMS > Fe(II)/PMS > UV/PMS...
August 8, 2018: Water Research
Tyler F Marcet, Natalie L Cápiro, Yi Yang, Frank E Löffler, Kurt D Pennell
Coupling in situ thermal treatment (ISTT) with microbial reductive dechlorination (MRD) has the potential to enhance contaminant degradation and reduce cleanup costs compared to conventional standalone remediation technologies. Impacts of low-temperature ISTT on Dehalococcoides mccartyi (Dhc), a relevant species in the anaerobic degradation of cis-1,2-dichloroethene (cis-DCE) and vinyl chloride (VC) to nontoxic ethene, were assessed in sand-packed columns under dynamic flow conditions. Dissolved tetrachloroethene (PCE; 258 ± 46 μM) was introduced to identical columns bioaugmented with the PCE-to-ethene dechlorinating consortium KB-1® ...
July 31, 2018: Water Research
Alankrita Raghavan, James M Wright, Christina Wright, Martha Sajatovic, Jonathan Miller
BACKGROUND: Cranioplasty after decompressive craniectomy is sometimes associated with significant morbidity. Dural substitutes during the initial decompression operation may improve outcome. METHODS: We performed a meta-analysis of online peer-reviewed databases to determine the impact of dural substitutes during decompressive craniectomy on operative metrics and outcome after subsequent cranioplasty. RESULTS: Nine studies published between 2006 and 2018 were identified that reported results from 922 patients undergoing autologous cranioplasty...
August 13, 2018: World Neurosurgery
K E Brown, J L Neva, S J Feldman, W R Staines, L A Boyd
Sensorimotor integration is the process through which somatosensory information is incorporated to inform motor output. Given its important behavioural implications, understanding the influence of healthy aging on the underlying neurophysiology of sensorimotor integration and whether it is modifiable through intervention is important. The aims of the current work were to: 1) profile aging-related differences in sensorimotor integration, and 2) to determine if sensorimotor integration in older adults can be modulated in response to sensory training...
August 13, 2018: Experimental Gerontology
Daniela Giustarini, Federico Galvagni, Isabella Dalle Donne, Aldo Milzani, Filiberto Maria Severi, Annalisa Santucci, Ranieri Rossi
Several drugs are currently in use as glutathione (GSH) enhancers in clinical, pre-clinical and experimental research. Here we compare the ability of N-acetylcysteine (NAC), 2-oxothiazolidine-4-carboxylic acid (OTC), glutathione ethyl ester (GSH-EE) and N-acetylcysteine ethyl ester (NACET) to increase the intracellular concentration of GSH using primary human umbilical vein endothelial cells (HUVEC) as in vitro model. Our experiments highlighted that NACET is largely the most efficient molecule in increasing the intracellular levels of GSH, cysteine, and γ-glutamylcysteine...
August 13, 2018: Free Radical Biology & Medicine
Fernanda Severo Sabedra Sousa, Paloma Taborda Birmann, Renata Balaguez, Diego Alves, César Augusto Brüning, Lucielli Savegnago
α-(phenylselanyl) acetophenone (PSAP) is an organoselenium compound that presents antidepressive-like and antinociceptive effect in animal models. In this study, we evaluate the potential pharmacological effects of PSAP on acute stress restriction (ARS)-induced depressive and anxiogenic-like behavior associated with hyperalgesia and mechanical allodynia in male adult Swiss mice (25-35 g). The ARS is an unavoidable stress situation that was applied for a period of 4 h using an individual rodent restraint...
August 13, 2018: Neurochemistry International
Tiziana Vercillo, Sean O'Neil, Fang Jiang
The ability to constantly anticipate events in the world is critical to human survival. It has been suggested that predictive processing originates from the motor system and that incoming sensory inputs can be altered to facilitate sensorimotor integration. In the current study, we investigated the role of the readiness potentials, i.e. the premotor brain activity registered within the fronto-parietal areas, in sensorimotor integration. We recorded EEG data during three conditions: a motor condition in which a simple action was required, a visual condition in which a visual stimulus was presented on the screen, and a visuomotor condition wherein the visual stimulus appeared in response to a button press...
August 13, 2018: NeuroImage
Xiao Du, Shaoping Yin, Fang Zhou, Xu Du, Jianan Xu, Xiaochen Gu, Guangji Wang, Juan Li
Stimuli-responsive nanocarriers have demonstrated their potentials in optimizing chemotherapeutics and anticancer efficacy. In this study, a mixed micelle system (THSP) was prepared by combining reduction-sensitive hyaluronic acid-poly(lactide) (HA-ss-PLA) conjugates and D-α-tocopheryl polyethylene glycol 1000 succinate (TPGS), with objective to achieve multiple functionalities of selective intracellular rapid release, active targeting capability and multidrug resistance reversal. The mixed micelle possessed desirable particle diameter of 124...
August 13, 2018: International Journal of Pharmaceutics
T D Paula, B R Silva, M D Grando, H C D Souza, L M Bendhack
AIM: To investigate the molecular mechanisms and cellular signaling pathways involved in the activation of TP receptors and the consequent induction of contractile responses in coronary arteries of renal hypertensive (2K-1C) rats. METHODS AND RESULTS: The coronary perfusion pressure (CPP) was lower in 2K-1C rats during increased coronary flow as measured by the Langendorff technique. The coronary contraction and relaxation were evaluated by vascular reactivity studies, and the molecular mechanisms were investigated on the basis of the protein expression of TP receptors, Cav-1, eNOS, COX-1, and COX-2, as measured by Western blot...
August 13, 2018: Journal of Molecular and Cellular Cardiology
Katrin Roth, Hans Peter Zahradnik, Wolfgang R Schäfer
OBJECTIVE: To compare the effects of chlormadinone acetate (CMA), dienogest (DNG) and drospirenone (DRSP) on prostaglandin biosynthesis in a human endometrial explants model. STUDY DESIGN: Human endometrial explants obtained by aspiration curettage and human endometrial YHES cells were stimulated with interleukin-1ß (IL-1ß) and exposed to CMA, DNG, DRSP or dexamethasone (DEX; YHES cells). Cellular messenger RNA (mRNA) levels of cyclooxygenase-2 (COX-2) were analyzed by reverse transcription-quantitative real-time polymerase chain reaction (RT-qPCR)...
August 13, 2018: Contraception
Jin-Heng Li, Li-Jun Wu, Ren-Jie Song, Shenglian Luo
A new palladium-catalysed reductive [5+1] cycloaddition of 3-acetoxy-1,4-enynes with CO enabled by hydrosilanes is developed for producing valuable functionalized phenols. This methodology employs hydrosilanes as the external functional reagents to fulfil the [5+1] carbonylative benzannulation, and is featured as a conceptually and mechanistically novel carbonylative cycloaddition route to construct substituted phenols through the formation of four new chemical bonds with excellent functional group tolerance...
August 16, 2018: Angewandte Chemie
Kim Vieira Kayat, Luiz Roisman, Claudio Zett, Eduardo A Novais, Michel Eid Farah
BACKGROUND AND OBJECTIVE: To illustrate how optical coherence tomography (OCT) angiography (OCTA) can be misinterpreted if not evaluated along with structural en face OCT to analyze the signal intensity. PATIENTS AND METHODS: Patients with different macular diseases associated with suspicious flow impairment in the choriocapillaris were recruited to be imaged on the RTVue XR Avanti device (Optovue, Fremont, CA) with the Angio Retina mode. En face OCT angiograms, structural en face OCT, and corresponding OCT B-scans with flow signal overlaid were compared to evaluate the correspondence of signal strength to areas of flow reduction in the choriocapillaris...
August 1, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
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