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Ashley Rankin, CaSandra Swearingen-Stanborough, Douglas A Granger, Jennifer Byrd-Craven
Attunement, or synchrony, of behavior and physiology has been well documented in family, mother-child, and romantic relationships. This study aimed to determine whether attunement of the hypothalamic-pituitary-adrenal (HPA) axis occurs in women's close friendships, and the role of a common social style, co-rumination in that attunement. Saliva samples (later assayed for cortisol) were collected from 37 dyads (74 individuals) during a laboratory task in which they were either asked to work together toward a common goal (control task) or discuss interpersonal problems, providing opportunity for co-rumination...
July 26, 2018: Psychoneuroendocrinology
Saul Lozano-Fuentes, Joan L Kenney, Wendy Varnado, Brian D Byrd, Kristen L Burkhalter, Harry M Savage
The rapid expansion of Zika virus (ZIKV), following the recent outbreaks of Chikungunya virus, overwhelmed the public health infrastructure in many countries and alarmed many in the scientific community. Aedes aegypti (L.) (Diptera: Culicidae) and Aedes albopictus (Skuse) (Diptera: Culicidae) have previously been incriminated as the vectors of these pathogens in addition to dengue virus. In our study, we challenged low generation Ae. aegypti (Chiapas, Mexico) and Ae. albopictus (North Carolina, Mississippi), with three strains of ZIKV, Puerto Rico (GenBank: KU501215), Honduras (GenBank: KX694534), and Miami (GenBank: MF988743)...
August 9, 2018: Journal of Medical Entomology
James Brian Byrd, David E Newby, Julie A Anderson, Peter M A Calverley, Bartolome R Celli, Nicholas J Cowans, Courtney Crim, Fernando J Martinez, Jørgen Vestbo, Julie Yates, Robert D Brook
Aims: To characterize the relationship between blood pressure (BP) or heart rate and mortality and morbidity in chronic obstructive pulmonary disease (COPD). Methods and results: We performed post hoc analysis of baseline BP or heart rate and all-cause mortality and cardiovascular events in the SUMMIT trial. SUMMIT was a randomized double-blind outcome trial of 16 485 participants (65 ± 8 years, 75% male, and 47% active smokers) enrolled at 1368 sites in 43 countries...
August 7, 2018: European Heart Journal
Kaitlyn M Eck, Colleen L Delaney, Miriam P Leary, Oluremi A Famodou, Melissa D Olfert, Karla P Shelnutt, Carol Byrd-Bredbenner
Larger portion sizes have increased in tandem with the rise in obesity. Elucidation of the cognitions of children and parents related to portion size is needed to inform the development of effective obesity prevention programs. This study examined cognitions of parents ( n = 36) and their school-age children (6 to 11 years; n = 35) related to portion sizes via focus group discussions. Parents and children believed controlling portion sizes promoted health and weight control. Some parents felt controlling portions was unnecessary, particularly if kids were a healthy weight because kids can self-regulate intake...
August 8, 2018: Nutrients
Susan Morgello, Michelle Jacobs, Jacinta Murray, Desiree Byrd, Eric Neibart, Letty Mintz, Gregory Meloni, Christina Chon, John Crary
With aging of HIV populations, there is concern that Alzheimer's disease (AD) may become prevalent and difficult to distinguish from HIV-associated neurocognitive disorders. To date, there are no reports documenting histologically verified Alzheimer's neuropathology in individuals with HIV and dementia. Herein, we report two antiretroviral-treated, virally suppressed, HIV-infected individuals autopsied by the Manhattan HIV Brain Bank. Subject A presented to study at 52 years, already dependent in instrumental activities of daily living (ADLs), with severe cognitive impairment inclusive of learning and memory dysfunction...
August 9, 2018: Journal of Neurovirology
Sean David Reiff, Rose Mantel, Lisa L Smith, Joseph T Greene, Elizabeth M Muhowski, Catherine A Fabian, Virginia M Goettl, Minh Tran, Bonnie Harrington, Kerry A Rogers, Farrukh T Awan, Kami Maddocks, Leslie Andritsos, Amy M Lehman, Deepa Sampath, Rosa Lapalombella, Sudharshan Eathiraj, Giovanni Abbadessa, Brian Schwartz, Amy Johnson, John C Byrd, Jennifer A Woyach
Targeted inhibition of Bruton's tyrosine kinase (BTK) with the irreversible inhibitor ibrutinib has improved outcomes for patients with hematologic malignancies, including chronic lymphocytic leukemia (CLL). Here we describe preclinical investigations of ARQ 531, a potent, reversible inhibitor of BTK with additional activity against Src family kinases and kinases related to ERK signaling. We hypothesized that targeting additional kinases would improve global inhibition of signaling pathways, producing more robust responses...
August 9, 2018: Cancer Discovery
Shailender Bhatia, Natalie J Miller, Hailing Lu, Natalie Vandeven Vandeven, Dafina Ibrani, Michi Shinohara, David Byrd, Upendra Parvathaneni, Rima M Kulikauskas, Jan Ter Meulen, Frank J Hsu, David M Koelle, Paul Nghiem
PURPOSE: G100 is a toll-like receptor 4 (TLR4) agonist that triggers innate and adaptive anti-tumor immune responses in preclinical models. This pilot study assessed the safety, efficacy, and immunologic activity of intratumoral (IT) administration of G100 in patients with Merkel cell carcinoma (MCC). EXPERIMENTAL DESIGN: Patients with loco-regional MCC (n=3; Cohort A) received neoadjuvant IT G100 (2 weekly doses at 5 μg/dose) followed by surgery and radiotherapy; patients with metastatic MCC (n=7; Cohort B) received 3 doses in a 6-week cycle and could receive additional cycles with/without radiotherapy...
August 9, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
Laura Adamovicz, Katie Leister, John Byrd, Christopher A Phillips, Matthew C Allender
Sustainable wildlife populations depend on healthy individuals, and the approach to determine wellness of individuals is multifaceted. Blood gas analysis serves as a useful adjunctive diagnostic test for health assessment, but it is uncommonly applied to terrestrial reptiles. This study established reference intervals for venous blood gas panels in free-living eastern box turtles ( Terrapene carolina carolina , N = 102) from Illinois and Tennessee, and modeled the effects of environmental and physiologic parameters on each blood gas analyte...
2018: Conservation Physiology
Yoonjeong Lee, Samantha Gordon Danner, Benjamin Parrell, Sungbok Lee, Louis Goldstein, Dani Byrd
This study uses a maze navigation task in conjunction with a quasi-scripted, prosodically controlled speech task to examine acoustic and articulatory accommodation in pairs of interacting speakers. The experiment uses a dual electromagnetic articulography set-up to collect synchronized acoustic and articulatory kinematic data from two facing speakers simultaneously. We measure the members of a dyad individually before they interact, while they are interacting in a cooperative task, and again individually after they interact...
2018: PloS One
Elizabeth M Byrd, Rita J Jablonski, David E Vance
BACKGROUND: Anosognosia for hemiplegia (AHP) after stroke is a complex cognitive behavioral disorder that removes awareness of one-sided paralysis (hemiplegia). As a result, stroke survivors afflicted with AHP may be more likely to have unrealistic expectations for stroke rehabilitation, display unsafe behaviors and experience falls, and ultimately suffer the physical and psychological consequences of frequent falling. OBJECTIVE: The purpose of this article is to describe AHP by discussing anosognosia within the context of contemporary theoretical understandings, examining current imaging evidence of the disorder, and summarizing emerging interventions designed to reinstate self-awareness in anosognosic patients...
August 6, 2018: Rehabilitation Nursing: the Official Journal of the Association of Rehabilitation Nurses
Neha G Goyal, Kami J Maddocks, Amy J Johnson, John C Byrd, Travis D Westbrook, Barbara L Andersen
Background: Chronic lymphocytic leukemia is the most prevalent adult leukemia. The disease is incurable with a cycling of treatment and relapse common. Little is known about the psychological and physical functioning of patients with relapsed/refractory chronic lymphocytic leukemia. Cancer-specific stress is an important individual difference variable that predicts psychological and physical outcomes. Purpose: To examine cancer-specific stress at treatment initiation as a predictor of psychological and physical functioning trajectories in patients with relapsed/refractory chronic lymphocytic leukemia during the first 5 months of treatment...
March 15, 2018: Annals of Behavioral Medicine: a Publication of the Society of Behavioral Medicine
Geoffrey A Coalson, Courtney T Byrd, Shanley B Treleaven, Lillian Dang
Non-word repetition is weaker for adults who stutter (AWS) compared to adults who do not stutter (AWNS) as phonological demands increase. However, non-word stimuli used in previous studies varied by length, but did not vary with regard to segmental or metrical complexity. The purpose of the present study was to examine the unique influence of these two distinct types of complexity on non-word repetition in AWS and AWNS via administration of the Test of Phonological Structure (TOPhS). Twenty-four adults (12 AWNS, 12 AWS) repeated 96 non-words within a soundproof booth immediately after auditory presentation...
August 7, 2018: Clinical Linguistics & Phonetics
M Byrd, C E Dixon, B Lucke-Wold
Concussion in athletes can contribute to early neuropsychological changes that may be indicative of future neurodegenerative disease. One of the hallmark findings of chronic traumatic encephalopathy is anxiety and impulsive behavior that often develops early in the course of the disease. The behavioral dysfunction can be grouped into a broader category referred to as cognitive disruption. The current gold standard for diagnosing chronic neurodegeneration is post-mortem evaluation of tauopathy to identify neurofibrillary tau tangles in neurons...
May 2018: Journal of Neurology and Psychology
Dustin A Pardini, Amy L Byrd, Samuel W Hawes, Meagan Docherty
OBJECTIVE: The aims of this study were to examine whether dispositional interpersonal callousness, negative emotionality, and hyperactivity/impulsivity uniquely influence the development of childhood-onset conduct problems and persistent criminal behavior in males, and to determine whether specific facets of negative emotionality (dysregulated anger versus anxiety) in childhood are differentially associated with the development of chronic antisocial behavior. METHOD: Childhood dispositional features and conduct problems were assessed semiannually using parent- and teacher-report measures across 9 consecutive assessments in a school-based sample of 503 boys (∼7-11 years of age)...
August 2018: Journal of the American Academy of Child and Adolescent Psychiatry
Brett A Izzo, Charles J Stoudenmire, Benjamin F Byrd
No abstract text is available yet for this article.
December 2017: CASE: Cardiovascular Imaging Case Reports
William V Padula, Jeromie Ballreich, Gerard F Anderson
In 2018, the Medicare Part D catastrophic threshold is $5000 in out-of-pocket total drug spending incurred by the beneficiary. Above this, Medicare pays 80%, prescription drug plans (PDPs) pay 15%, and beneficiaries pay a 5% copay. However, recent growth in catastrophic spending is caused by expensive specialty drugs. The 5% copay, on top of out-of-pocket spending, could result in beneficiaries not accessing specialty drugs. To assist beneficiaries, the Medicare Payment Advisory Commission (MedPAC) proposes to eliminate beneficiary catastrophic cost sharing, while PDPs pay 80% and Medicare pays 20%...
July 30, 2018: Applied Health Economics and Health Policy
Daniel A Hunter, Leah K Bartel, Ian Byrd, Bethany Bogan, Wilson Yau, Ji Wu, Worlanyo Eric Gato
Titanium dioxide nanofiber (TDNF) is widely used in the manufacture of various household products, including cosmetics. As a result, the possibility exists for TDNFs to affect human health. Because the kidneys are responsible for filtering out waste from the blood, the goal of the present study was to investigate the short-term effects of TDNF on kidney function of male Sprague Dawley rats. To achieve study objectives, 6- to 7-wk-old male rats were exposed via oral gavage to a total of 0, 40, and 60 parts per million of TDNF for 2 wk...
2018: Journal of Environmental Pathology, Toxicology and Oncology
David Galloway, Ethan Mezoff, Wujuan Zhang, Melissa Byrd, Conrad Cole, Inmaculada Aban, Samuel Kocoshis, Kenneth Dr Setchell, James E Heubi
BACKGROUND: We determined qualitative and quantitative serum unconjugated bile acid (SUBA) levels among children with history of intestinal failure (IF) and suspected small bowel bacterial overgrowth (SBBO). METHODS: This was a single-center, case-control pilot study conducted at Cincinnati Children's Hospital Medical Center. Children with history of IF and suspected SBBO were enrolled as subjects. Age-matched children without IF or suspected SBBO served as controls...
July 23, 2018: JPEN. Journal of Parenteral and Enteral Nutrition
John C Byrd, Amy S Ruppert, Nyla A Heerema, Alese E Halvorson, Eva Hoke, Mitchell R Smith, John E Godwin, Stephen Couban, Todd A Fehniger, Michael J Thirman, Martin S Tallman, Frederick R Appelbaum, Richard M Stone, Sue Robinson, Julie E Chang, Sumithra J Mandrekar, Richard A Larson
Prior to novel targeted agents for chronic lymphocytic leukemia (CLL), the best chemoimmunotherapy regimen in patients with non-del(11q) disease was unclear. The role of lenalidomide was also not defined. This phase 2 study randomized 342 untreated patients with non-del(11q) CLL requiring therapy to fludarabine plus rituximab (FR; n = 123), FR plus lenalidomide consolidation (FR+L; n = 109), or FR plus cyclophosphamide (FCR; n = 110) and compared 2-year progression-free survival (PFS) rates of each to the historical control rate with FC (60%)...
July 24, 2018: Blood Advances
John C Byrd
No abstract text is available yet for this article.
July 19, 2018: Blood
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