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Jackson J Scheib, Joanna M Pozzuto, Christine A Byrd-Jacobs
BACKGROUND: Deafferentation of the zebrafish olfactory bulb allows investigation of neuroplasticity in a particularly dynamic brain region of a popular model animal known for its regenerative abilities. Current methods to remove sensory input to the zebrafish olfactory bulb differ in the extent of deafferentation and potential for recovery. NEW METHOD: We present a novel method of olfactory bulb deafferentation using continuous wax plug insertions into the nasal cavity of zebrafish...
October 11, 2018: Journal of Neuroscience Methods
Melissa D Olfert, Makenzie L Barr, Camille M Charlier, Oluremi A Famodu, Wenjun Zhou, Anne E Mathews, Carol Byrd-Bredbenner, Sarah E Colby
Self-reported height and weight, if accurate, provide a simple and economical method to track changes in body weight over time. Literature suggests adults tend to under-report their own weight and that the gap between self-reported weight and actual weight increases with obesity. This study investigates the extent of discrepancy in self-reported height, weight, and subsequent Body Mass Index (BMI) versus actual measurements in young adults. Physically measured and self-reported height and weight were taken from 1562 students...
October 11, 2018: International Journal of Environmental Research and Public Health
DeAnnah R Byrd, Gilbert C Gee, Wassim Tarraf
Objectives: Studies of older U.S. adults have consistently found that African Americans perform worse on cognitive measures than whites, but there are inconsistencies as to whether these findings hold over time. Moreover, studies have focused on adults 51 and older, without considering younger ages; thus it is unclear the age at which these disparities surface. The present study examines black-white disparities in mental status trajectories among adults as young as 25 years over a 25-year period...
December 2018: SSM—Population Health
Elizabeth R Duvall, Jennifer Pan, Kim Tien T Dinh, Majd Al Shaarani, Golden Pan, Marlyn P Langford, William A Byrd
Purpose: To show the utility of MRI and histology in diagnosing rare cases of trigeminal hypertrophic interstitial neuropathy (HIN). Observations: A 57-year-old African-American woman presented with a 4-year history of right eye proptosis with tearing, headaches, and worsening right-sided trigeminal neuralgia symptoms and jaw pain. HIV and diabetes tests were negative and thyroid function was normal. MRI identified abnormal thickening of all trigeminal nerve divisions and proptosis secondary to right trigeminal nerve V1 division enlargement...
December 2018: American Journal of Ophthalmology Case Reports
Christopher J Walker, Christopher C Oakes, Luke K Genutis, Brian Giacopelli, Sandya Liyanarachchi, Deedra Nicolet, Ann-Kathrin Eisfeld, Markus Scholz, Pamela Brock, Jessica Kohlschmidt, Krzysztof Mrózek, Marius Bill, Andrew J Carroll, Jonathan E Kolitz, Bayard L Powell, Eunice S Wang, Dietger W Niederwieser, Richard M Stone, John C Byrd, Sebastian Schwind, Albert de la Chapelle, Clara D Bloomfield
No abstract text is available yet for this article.
October 5, 2018: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
M Gentry Byrd, Rocio B Quinonez, Kelly Lipp, Alice Chuang, Ceib Phillips, Jane A Weintraub
OBJECTIVES: To evaluate characteristics of pregnant women served through the University of North Carolina's (UNC) prenatal oral health program (pOHP) dental clinic and community healthcare pathways to inform efforts in promoting prenatal oral health policies. METHODS: The pOHP provides medical and dental students and practitioners with interprofessional experiences caring for pregnant women. A retrospective chart audit captured 314 pregnant women who made appointments over 33 months...
October 4, 2018: Journal of Public Health Dentistry
Brian D Byrd, Carl J Williams, J Erin Staples, Kristen L Burkhalter, Harry M Savage, Michael S Doyle
No abstract text is available yet for this article.
October 5, 2018: MMWR. Morbidity and Mortality Weekly Report
Andreas Keyser, Simon Schopka, Carsten Jungbauer, Maik Foltan, Christof Schmid
BACKGROUND: In cases of lead failure after implantation of pacemakers (PM) or implantable cardioverter defibrillators (ICD) early lead replacement may be challenging. Puncture of the subclavian vein bears possible complications such as pneumothorax, hematothorax, and damage of leads to be left in place. To avoid venous puncture PM or ICD leads were replaced using a flexible polypropylene sheath (Byrd-sheath). METHOD: From January 2010 through December 2017, 55 patients underwent early lead exchange avoiding venous puncture...
October 3, 2018: Journal of Cardiothoracic Surgery
Jacqueline C Barrientos, Jan A Burger, John C Byrd, Peter Hillmen, Cathy Zhou, Joi Ninomoto, Danelle F James, Thomas J Kipps
Increased absolute lymphocyte count (ALC) is a key feature of chronic lymphocytic leukemia (CLL) but is also observed during treatment with B-cell receptor pathway inhibitors including ibrutinib, a first-in-class inhibitor of Bruton's tyrosine kinase. In patients with CLL treated with single-agent ibrutinib in two multicenter, open-label, randomized, phase 3 studies (RESONATE-2, NCT01722487; RESONATE, NCT01578707), lymphocytosis was observed in 77 of 136 (57%) patients treated in first-line and 133 of 195 (69%) relapsed/refractory patients...
October 2, 2018: Leukemia & Lymphoma
Colin Fuller, J Kenneth Byrd, Michael Groves
Although the field of otolaryngology has experienced a decline in the number of applicants to our residency programs, otolaryngology remains a highly competitive field with an extremely strong applicant pool. Many highly qualified candidates cannot obtain a position in our field each year, and many of these candidates choose to reapply the next year. Data are lacking regarding reapplicants' success rate and the best gap year employment and training options for these reapplicants. Reapplicants were studied prospectively via a two-stage survey during the 2014-2015 and 2015-2016 application cycles...
September 2018: Ear, Nose, & Throat Journal
Bridgett Byrd Sellars, Dennis R Sherrod, Lolita Chappel-Aiken
No abstract text is available yet for this article.
October 2018: Nursing Management
Alicia K Byrd, Matthew R Bell, Kevin D Raney
In addition to unwinding double-stranded nucleic acids, helicase activity can also unfold noncanonical structures such as G-quadruplexes.  We previously characterized Pif1 helicase catalyzed unfolding of parallel G-quadruplex DNA.  Here we characterized unfolding of telomeric G-quadruplex which can fold into anti-parallel and mixed hybrid structures and found significant differences.  Telomeric DNA sequences are unfolded more readily than the parallel quadruplex formed by the c-MYC promoter in K+   Furthermore, we found that under conditions in which the telomeric quadruplex is less stable, such as in Na+ , Pif1 traps thermally melted quadruplexes in the absence of ATP, leading to the appearance of increased product formation under conditions in which the enzyme is pre-incubated with the substrate...
September 26, 2018: Journal of Biological Chemistry
Jordan Beardslee, Sachiko Datta, Amy Byrd, Madeline Meier, Seth Prins, Magdalena Cerda, Dustin Pardini
Although peer behavior and parent-child-conflict have been associated with adolescent and young adults' behavior, prior studies have not adequately controlled for selection effects and other confounders, or examined whether associations change across the transition to adulthood or by race. Using annual data from young men followed from 17-26, within-individual change models examined whether substance use or offending increased in the year after boys began affiliating with friends who engaged in substance use/offending and/or experienced increased parent-son-conflict...
June 2018: Criminal Justice and Behavior
Jacqueline C Barrientos, Susan O'Brien, Jennifer R Brown, Neil E Kay, Nishitha M Reddy, Steven Coutre, Constantine Tam, Stephen Mulligan, Ulrich Jaeger, Stephen Devereux, Christopher Pocock, Tadeusz Robak, Stephen J Schuster, Anna Schuh, Devinder Gill, Adrian Bloor, Claire Dearden, Carol Moreno, Gavin Cull, Mike Hamblin, Jeffrey A Jones, Karl Eckert, Isabelle G Solman, Samuel Suzuki, Emily Hsu, Danelle F James, John C Byrd, Peter Hillmen
BACKGROUND: Ibrutinib compared with ofatumumab significantly improves progression-free and overall survival in patients with previously treated chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL). PATIENTS AND METHODS: Measures of well-being were assessed in RESONATE, where previously treated patients with CLL/SLL were randomized to receive ibrutinib 420 mg/day (n = 195) or ofatumumab (n = 196) for up to 24 weeks. Endpoints included hematologic function, Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F), disease-related symptoms, European Organization for Research and Treatment of Cancer Quality of Life Questionnaires Core 30 (EORTC QLQ-C30), and medical resource utilization...
August 18, 2018: Clinical Lymphoma, Myeloma & Leukemia
Aya T Nanba, Taweesak Wannachalee, James J Shields, James B Byrd, William E Rainey, Richard J Auchus, Adina F Turcu
Context: Many antihypertensive medications modulate the renin-angiotensin-aldosterone system, possibly skewing the diagnosis and subtyping of primary aldosteronism (PA). Particularly, mineralocorticoid receptor antagonists (MRA) might raise renin and stimulate aldosterone synthesis from non-autonomous areas, potentially obscuring lateralization on adrenal vein sampling (AVS). Withdrawal of MRA in severe PA, however, can precipitate hypokalemia and/or hypertension and therefore is not always practical...
September 14, 2018: Journal of Clinical Endocrinology and Metabolism
Alex J Fauer, Flora Hoodin, Leah Lalonde, Josh Errickson, Lyndsey Runaas, Tracey Churay, Sajjad Seyedsalehi, Casiana Warfield, Grant Chappell, Kristina Brookshire, Dima Chaar, Ji Youn Shin, Michelle Byrd, John Magenau, David A Hanauer, Sung Won Choi
PURPOSE: We developed BMT Roadmap, a health information technology (HIT) application on a tablet, to address caregivers' unmet needs with patient-specific information from the electronic health record. We conducted a preliminary feasibility study of BMT Roadmap in caregivers of adult and pediatric HSCT patients. The study was registered on (NCT03161665; NCT02409121). METHODS: BMT Roadmap was delivered to 39 caregivers of adult and pediatric patients undergoing first-time HSCT at a single study site...
September 20, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
Courtney T Byrd, Zoi Gkalitsiou, Danielle Werle, Geoffrey A Coalson
The purpose of this follow-up study was to explore the effectiveness of an intensive treatment program- Camp Dream. Speak. Live .-within older, school-age children who stutter. Twenty-three school-age children who stutter (age range: 7-14 years) attended this week-long intensive therapy program for the first time. Outcome measures included Overall Assessment of the Speaker's Experience of Stuttering and the Patient Reported Outcomes Measurement Information System Pediatric Peer Relationships Form. Findings demonstrate significant improvements in quality of life and communication attitudes can be achieved in a short period of time when increasing fluency is not a target...
September 19, 2018: Seminars in Speech and Language
David C Stockwell, Cherie Thomas, Evan S Fieldston, Matt Hall, Angela S Czaja, Erika L Stalets, Jefry Biehler, Maeve Sheehan, Dorothy Foglia, Susan Byrd, Richard E McClead
Objectives: Develop and test a new metric to assess meaningful variability in inpatient flow. Methods: Using the pediatric administrative dataset, Pediatric Health Information System, that quantifies the length of stay (LOS) in hours, all inpatient and observation encounters with 21 common diagnoses were included from the calendar year 2013 in 38 pediatric hospitals. Two mutually exclusive composite groups based on diagnosis and presence or absence of an ICU hospitalization termed Acute Care Composite (ACC) and ICU Composite (ICUC), respectively, were created...
January 2018: Pediatric Quality & Safety
Shreela V Sharma, Elizabeth Vandewater, Ru-Jye Chuang, Courtney Byrd-Williams, Steven Kelder, Nancy Butte, Deanna M Hoelscher
BACKGROUND: This study presents the impact of a 2-year implementation of Coordinated Approach to Child Health Early Childhood (CATCH EC), a preschool-based healthy nutrition and physical activity program, on child BMI z-scores, BMI percentiles, diet, physical activity, and sedentary behaviors among 3- to 5-year old children across Head Start centers in Houston and Austin, Texas. METHODS: We used a quasi-experimental study design with serial cross-sectional data collection (Intervention catchment area: n = 12 centers, 353 parent-child dyads in Year 1; n = 12 centers, 365 parent-child dyads; Comparison catchment area: n = 13 centers in year 1, 319 parent child dyads; and n = 12 centers, 483 parent-child dyads in year 2)...
September 18, 2018: Childhood Obesity
Jacob Freeman, Jacopo A Baggio, Erick Robinson, David A Byers, Eugenia Gayo, Judson Byrd Finley, Jack A Meyer, Robert L Kelly, John M Anderies
We conduct a global comparison of the consumption of energy by human populations throughout the Holocene and statistically quantify coincident changes in the consumption of energy over space and time-an ecological phenomenon known as synchrony. When populations synchronize, adverse changes in ecosystems and social systems may cascade from society to society. Thus, to develop policies that favor the sustained use of resources, we must understand the processes that cause the synchrony of human populations. To date, it is not clear whether human societies display long-term synchrony or, if they do, the potential causes...
October 2, 2018: Proceedings of the National Academy of Sciences of the United States of America
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