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Observation management

Neha Rastogi, Surbhi Khurana, Balaji Veeraraghavan, Francis Yesurajan Inbanathan, Suresh Kumar Rajamani Sekar, Deepak Gupta, Keshav Goel, Ashish Bindra, Navdeep Sokhal, Ashutosh Panda, Rajesh Malhotra, Purva Mathur
OBJECTIVE: This study describes a detailed epidemiological and molecular characterization of an outbreak of Burkholderia cepacia at a neuro-trauma intensive care unit of a level-1 trauma centre. It emphasizes stringent infection control interventions taken to successfully curb this outbreak. METHODS: Clinical and microbiological data was reviewed for the patients, who had more than one blood culture that grew B. cepacia. Bacterial identification and antimicrobial susceptibility was done using automated VITEK II systems...
October 17, 2018: International Journal of Infectious Diseases: IJID
Chuanju Dong, Shengnan Kong, Xianhu Zheng, Jiangfan Zhang, Guoxing Nie, Xuejun Li, Peng Xu
Interleukin-17 (IL17) family cytokines are well known for having pro-inflammatory actions as important mediators of mucosal immune responses and are tightly regulated by various kinds of signals. However, most studies of IL17 genes have focused on mammals, and much less is known about IL17 genes in fish species. To better understand the scope and actions of the IL17 gene family in common carp, we characterized seven IL17 gene homologs from genomic and transcriptomic databases that could be classified into three subclasses according to different comparative genomic analyses...
October 17, 2018: Gene
Christopher Kabrhel, Rachel Rosovsky, Christopher Baugh, Jean Connors, Benjamin White, Nicholas Giordano, Jasmine Torrey, Erin Deadmon, Blair Alden Parry, Sean Hagan, Hui Zheng
OBJECTIVE: Determine whether a protocol combining risk-stratification, treatment with the direct acting oral anticoagulant rivaroxaban, and defined follow-up is associated with a greater proportion of patients with venous thromboembolism (VTE) treated as outpatients, without hospital admission. METHODS: We performed a multicenter study of patients diagnosed with VTE (pulmonary embolism [PE] or deep vein thrombosis [DVT]) in two urban EDs, 18 months before and 18 months after implementation of an outpatient VTE treatment protocol...
October 20, 2018: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
Devendra Saksena, S Muralidharan, Yugal K Mishra, Vivek Kanhere, Bipin Bihari Mohanty, C P Srivastava, Jagdish Mange, Manish Puranik, Manoj P Nair, Pankaj Goel, Pankaj Srivastava, R M Krishnan, Sathyaki Nambala, Vikrama Raja
Background: Prosthetic valve implantation requires postoperative prophylactic anticoagulation to preclude thrombotic events. The aim of this review is to assess the role of anticoagulation therapy in the management of valve replacement patients. Methodology: Literature from PubMed, Embase, Medline and Google Scholar were searched using the terms "valvular heart disease", "anticoagulant", "mechanical heart valve", "bioprosthesis", "bridging", "Vitamin K antagonist (VKA)", and "acenocoumarol"...
January 2018: Journal of the Association of Physicians of India
Nan Hong, Min Chen, Nan Xu, Abdullah M S Al-Hatmi, Chao Zhang, Wei H Pan, Ferry Hagen, Teun Boekhout, Jianping Xu, Xian B Zou, Wan Q Liao
Cryptococcosis is a life-threatening mycosis primarily occurring in adult patients particularly those with immunosuppression such as HIV infection/AIDS. The number of reported cases of pediatric cryptococcosis has increased in the last decade around the world, including China. However, current information on the characteristics of cryptococcosis in children, particularly the genotypic diversity and antifungal susceptibility of the isolates, is limited. In the present study, a total of 25 pediatric isolates of Cryptococcus neoformans were genotyped using the ISHAM-MLST scheme...
October 19, 2018: Mycoses
Wangshou Zhang, Dongqiang Chen, Hengpeng Li
The water quality of headwater streams is a worldwide concern because of their critical roles in supplying clean water for drinking and other consumptive uses. Here, we evaluate temporal trends and spatial dynamics of the permanganate index (COD), ammonia-nitrogen (AN), and total phosphorus (TP) for 31 sites in headwater watersheds of the Huai River Basin, China. The seasonal Mann-Kendall test and correlation and variance analyses were applied to long-term time series (2003-2010) of water quality data in order to investigate the patterns of water quality trends, as well as their linkages with the watershed landscape...
October 19, 2018: Environmental Science and Pollution Research International
Taylor C Harris, Rijk de Rooij, Ellen Kuhl
Cerebral atrophy in response to traumatic brain injury is a well-documented phenomenon in both primary investigations and review articles. Recent atrophy studies focus on exploring the region-specific patterns of cerebral atrophy; yet, there is no study that analyzes and synthesizes the emerging atrophy patterns in a single comprehensive review. Here we attempt to fill this gap in our current knowledge by integrating the current literature into a cohesive theory of preferential brain tissue loss and by identifying common risk factors for accelerated atrophy progression...
October 17, 2018: Annals of Biomedical Engineering
M Rodríguez-Barranco, E Salamanca-Fernández, M L Fajardo, E Bayo, Y-L Chang-Chan, J Expósito, C García, J Tallón, P Minicozzi, M Sant, D Petrova, M A Luque-Fernandez, M-J Sánchez
PURPOSE: The third most frequently diagnosed cancer in Europe in 2018 was lung cancer; it is also the leading cause of cancer death in Europe. We studied patient and tumor characteristics, and patterns of healthcare provision explaining regional variability in lung cancer survival in southern Spain. METHODS: A population-based cohort study included all 1196 incident first invasive primary lung cancer (C33-C34 according to ICD-10) cases diagnosed between 2010 and 2011 with follow-up until April 2015...
October 19, 2018: Clinical & Translational Oncology
Taha B M J Ouarda, Christian Charron
Persistent extreme heat events are of growing concern in a climate change context. An increase in the intensity, frequency and duration of heat waves is observed in several regions. Temperature extremes are also influenced by global-scale modes of climate variability. Temperature-Duration-Frequency (TDF) curves, which relate the intensity of heat events of different durations to their frequencies, can be useful tools for the analysis of heat extremes. To account for climate external forcings, we develop a nonstationary approach to the TDF curves by introducing indices that account for the temporal trend and teleconnections...
October 19, 2018: Scientific Reports
Fabrizio Maggi, Daniele Focosi, Maura Statzu, Gabriele Bianco, Cristina Costa, Lisa Macera, Pietro Giorgio Spezia, Chiara Medici, Eliseo Albert, David Navarro, Carolina Scagnolari, Mauro Pistello, Rossana Cavallo, Guido Antonelli
Monitoring the human virome has been recently suggested as a promising and novel area of research for identifying new biomarkers which would help physicians in the management of transplant patients. Imbalance of the immune system in transplant recipients has a significant impact on replication of Torquetenovirus (TTV), the most representative and abundant virus of human virome. TTV kinetic was studied by real-time PCR in 280 liver or kidney transplant recipients who underwent different drug regimens to maintain immunosuppression...
October 19, 2018: Scientific Reports
Mohammad Rostami, Seyyed Jalal Younesi, Farahnaz Mohammadi Shahboulaghi, Seyed Kazem Malakouti, Mahshid Foroughan
INTRODUCTION: The rates of suicide in the elderly population are generally higher than other age groups. Models of suicide that explain the phenomenon of suicide in later life may have research, clinical and educational implications for the field of ageing. The primary purpose of this systematic review is to identify and review existing models of suicide that have a particular focus on the elderly. METHODS AND ANALYSIS: The authors intend reviewing the findings of observational studies including cohort studies, cross-sectional studies, case-control studies, and qualitative studies such as grounded theory designs which are published in Google Scholar, Scopus, PsycINFO, PubMed, Web of Science, Cochrane Database of Systematic Reviews and research-related journals...
October 18, 2018: BMJ Open
Onur Asan, Farion Cooper Ii, Sneha Nagavally, Rebekah J Walker, Joni S Williams, Mukoso N Ozieh, Leonard E Egede
BACKGROUND: Emerging health technologies are increasingly being used in health care for communication, data collection, patient monitoring, education, and facilitating adherence to chronic disease management. However, there is a lack of studies on differences in the preference for using information exchange technologies between patients with chronic and nonchronic diseases and factors affecting these differences. OBJECTIVE: The purpose of this paper is to understand the preferences and use of information technology for information exchange among a nationally representative sample of adults with and without 3 chronic disease conditions (ie, cardiovascular disease [CVD], diabetes, and hypertension) and to assess whether these preferences differ according to varying demographic variables...
October 18, 2018: Journal of Medical Internet Research
William Ngo, Sruthi Srinivasan, Lyndon Jones
PURPOSE: To determine the effectiveness of the MGDRx EyeBag in managing meibomian gland dysfunction. METHODS: This was a prospective, randomized, controlled, observer-masked, bilateral eye study that enrolled 29 participants. Participants were randomized into either the EyeBag group or the control group. The EyeBag group used the EyeBag 10minutes 2x/day, and the control group remained on their own dry eye treatment regimen (if applicable). All participants were observed at baseline, 2 weeks (2wk) and 4 weeks (4wk)...
October 16, 2018: Journal of Optometry
Georgios Klironomos, Lior Gonen, Karolyn Au, Eric Monteiro, Alireza Mansouri, Mazda Keki Turel, Ian Witterick, Alan Vescan, Gelareh Zadeh, Fred Gentili
During the last two decades evolution of the endoscopic endonasal approaches (EEA) has offered the option of minimally invasive techniques in the management of esthesioneuroblastomas (ENB), either as endoscope assisted cranial resection or as pure endoscopic procedures. This study presents the use of pure EEA in the management of ENB in our center, along with a literature review. We retrospectively reviewed the clinical, radiology and pathology records of patients with ENB treated during the period July 2006 to January 2016...
October 16, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
Behnam Nabavizadeh, Reza Khorramirouz, Erfan Amini, Farhad Pishgar, Asal Hojjat, Abdol-Mohammad Kajbafzadeh
OBJECTIVE: To assess the role of urinary carbohydrate antigen 19-9 (CA19-9) measurement in determining optimal management of ureteropelvic junction obstruction (UPJO) and predicting failure of conservative management. PATIENTS AND METHODS: Children with UPJO diagnosed between December 2012 and April 2015 were included. Depending on clinical and para-clinical findings, patients were divided into three groups: Group 1 consisted of patients who were considered for non-operative management with improvement of the condition during the course of follow-up...
October 2, 2018: Journal of Pediatric Surgery
Masahiko Okumura, Sebastien Kerisit, Ian C Bourg, Laura N Lammers, Takashi Ikeda, Michel Sassi, Kevin M Rosso, Masahiko Machida
Insights at the microscopic level of the process of radiocesium adsorption and interaction with clay mineral particles have improved substantially over the past several years, triggered by pressing social issues such as management of huge amounts of waste soil accumulated after the Fukushima Dai-ichi nuclear power plant accident. In particular, computer-based molecular modeling supported by advanced hardware and algorithms has proven to be a powerful approach. Its application can now generally encompass the full complexity of clay particle adsorption sites from basal surfaces to interlayers with inserted water molecules, to edges including fresh and weathered frayed ones...
October 16, 2018: Journal of Environmental Radioactivity
S Buyle-Bodin, A Amad, F Medjkane, S Bourion-Bedes, P Thomas, T Fovet
BACKGROUND: In France, on the first of January 2018, 772 underage persons were in jail or about 1.1 % of the incarcerated population. The prevalence of psychiatric disorders among those inmates is high. As a result psychiatric care (and particularly full-time hospitalization) is essential for this population. The unités hospitalières spécialement aménagées (UHSA) are full-time inpatient hospitalization units for inmates in France. Adults but also underage inmates can be admitted to UHSA for voluntary or involuntary hospitalization...
October 16, 2018: L'Encéphale
S Tordjman, L Vaivre-Douret, S Chokron, S Kermarrec
We have been sensitized to children with high intellectual potential (HIP) having difficulties given the number of children consulting in our outpatient medico-psychological centres for scholastic problems (possibly leading to school failure), anxiety disorders or behavioral disorders such as attention deficit/hyperactivity disorder (ADHD), and in which a high intellectual potential was discovered during psychological assessments. It is the contrast, and more precisely the paradox, between the high intellectual potential of these children and their scholastic difficulties (including school failure), and the psychic suffering expressed by some of them, which led us to question, challenge and propose therapeutic and educational care adapted to these children...
October 16, 2018: L'Encéphale
Petra Mäkelä, Mary Godfrey, Andrea Cradduck-Bamford, Graham Ellis, Sasha Shepperd
BACKGROUND: Attempts to design services to support the delivery of healthcare closer to home have taken various forms as countries respond to an increase in hospital admission rates for older people, who are at risk of hospital-acquired morbidity, prolonged lengths of stay and readmission. Evidence to support the development of these services is limited. We are conducting a process evaluation, alongside a UK multi-site randomised trial, to understand the contexts and practices of implementing geriatrician-led admission avoidance hospital at home services and to explore ways that the intervention might be effective, under what conditions, for whom, and how it differs from inpatient care...
October 19, 2018: Trials
Wilbroad Mutale, Susan Cleary, Jill Olivier, Roma Chilengi, Lucy Gilson
BACKGROUND: Under the Doris Duke Charitable Foundation's African Health Initiative, five Population Health Implementation and Training partnerships were established as long-term health system strengthening projects in five Sub-Saharan Countries. In Zambia, the Centre for Infectious Disease Research in Zambia began to implement the Better Health Outcomes through Mentorship and Assessments (BHOMA) in 2009. This was a combined community and health systems project involving 42 public facilities and their catchment populations...
October 19, 2018: BMC Health Services Research
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