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Hyung-Jin Won, Hyun-Ju Ji, Jae Kyeong Song, Yeon-Dong Kim, Hyung-Sun Won
The aim of this study was to clarify the topographical relationships between the greater occipital nerve and the trapezius muscle and between the greater occipital nerve and the occipital artery in the occiput in order to increase the success rate of greater occipital nerve blockade. Fifty-six halved heads of 28 cadavers were used in this study. The piercing points and the courses of the greater occipital nerve and occipital artery were analyzed by dividing a line connecting between the external occipital protuberance and mastoid process into three equal parts...
2018: PloS One
Monica C Campos, Jamille G Dombrowski, Jody Phelan, Claudio R F Marinho, Martin Hibberd, Taane G Clark, Susana Campino
Zika virus infections can cause a range of neurologic disorders including congenital microcephaly. However, while Zika infections have been notified across all regions in Brazil, there has been an unusual number of congenital microcephaly case notifications concentrated in the Northeast of the country. To address this observation, we investigated epidemiological data (2014-2016) on arbovirus co-distribution, environmental and socio-economic factors for each region in Brazil. Data on arbovirus reported cases and microcephaly were collected from several Brazilian Ministry of Health databases for each Federal unit...
2018: PloS One
Yelena Y Janjigian, Johanna Bendell, Emiliano Calvo, Joseph W Kim, Paolo A Ascierto, Padmanee Sharma, Patrick A Ott, Katriina Peltola, Dirk Jaeger, Jeffry Evans, Filippo de Braud, Ian Chau, Christopher T Harbison, Cecile Dorange, Marina Tschaika, Dung T Le
Purpose Metastatic esophagogastric cancer treatments after failure of second-line chemotherapy are limited. Nivolumab demonstrated superior overall survival (OS) versus placebo in Asian patients with advanced gastric or gastroesophageal junction cancers. We assessed the safety and efficacy of nivolumab and nivolumab plus ipilimumab in Western patients with chemotherapy-refractory esophagogastric cancers. Patients and Methods Patients with locally advanced or metastatic chemotherapy-refractory gastric, esophageal, or gastroesophageal junction cancer from centers in the United States and Europe received nivolumab or nivolumab plus ipilimumab...
August 15, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
Ju Tian, Xiao Xuan Lei, Li Xuan, Jian Bing Tang, Biao Cheng
BACKGROUND AND OBJECTIVES: Plasma skin regeneration (PSR) and platelet-rich plasma(PRP) have gained popularity in the treatment of acne scars due to their efficacy and improved tolerability. The objective of this investigation was to evaluate the synergistic effect of PRP plus PSR (plasma-combined regeneration technology, PCRT) in managing facial acne scars. METHODS: From March 2015 to June 2017,a total of 25 cases with facial atrophic acne scars were treated with PCRT treatment for three to five times...
August 15, 2018: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
Lenycia de Cassya Lopes Neri, Denise Pimentel Bergamaschi, Luiz Vicente Ribeiro Ferreira da Silva Filho
OBJECTIVE: To evaluate the nutritional profile of the population assisted at a reference center for cystic fibrosis treatment. METHODS: Cross-sectional study including patients with cystic fibrosis assisted at a pediatric reference center in São Paulo, Brazil, in 2014. All patients attending regular visits who agreed to participate in the study were included. A questionnaire on dietary habits (24-hour diet recall) and socioeconomic characteristics was applied. Anthropometric data (compared with the reference from the World Health Organization, 2006 and 2007) and pulmonary function data were collected from medical records...
August 9, 2018: Revista Paulista de Pediatria: Orgão Oficial da Sociedade de Pediatria de São Paulo
Rarianne Carvalho Peruhype, Fernando Mitano, Juliana Feliciati Hoffmann, Catiucia de Andrade Surniche, Pedro Fredemir Palha
OBJECTIVE: to investigate the planning pathways in the transfer of Directly Observed Treatment of tuberculosis. METHOD: a qualitative study conducted using interviews and a semi-structured guide, administered to five subjects who were among the coordinators and managers of the tuberculosis control programs, and the secretary of health of a municipality in the south of Brazil. Situational Strategic Planning and Discourse Analysis of the French matrix were the theoretical and analytical references used, respectively...
August 9, 2018: Revista Latino-americana de Enfermagem
Laura Luque-Sastre, Edward M Fox, Kieran Jordan, Séamus Fanning
Listeria species are ubiquitous in nature and can adapt to survive in a variety of niches, including food processing environments. Listeria species that colonize these environments may also have the potential to persist. Food safety strategies designed to manage these niches include regular cleaning and disinfection with proven sanitizers containing biocide-active compounds. Typically, these sanitizers are effective against bacteria growing under planktonic conditions, but their efficacy may be compromised when bacteria are contained in biofilms...
August 15, 2018: Journal of Food Protection
Y N Prashantha, P N Suman Rao, Saudamini Nesargi, B S Chandrakala, Kalyan Chakravarthy Balla, A Shashidhar
BACKGROUND: Different methods have been used for therapeutic hypothermia for neonates with moderate-to-severe hypoxic ischaemic encephalopathy (HIE). As standard cooling devices are expensive, there is a need to establish the safety and efficacy of low-cost devices such as ice packs (IP) and phase changing material (PCM). AIM: To assess the efficacy and safety of therapeutic hypothermia (TH) and the clinico-laboratory profile of neonates who underwent cooling with IP or PCM...
August 15, 2018: Paediatrics and International Child Health
Stefano Gentileschi, Antonio Vitale, Donato Rigante, Giuseppe Lopalco, Giacomo Emmi, Ida Orlando, Gerardo Di Scala, Jurgen Sota, Claudia Fabiani, Bruno Frediani, Mauro Galeazzi, Giovanni Lapadula, Florenzo Iannone, Luca Cantarini
BACKGROUND: Clinical research is needed to identify patients with axial spondyloarthritis (axSpA) who are more likely to be responsive to interleukin (IL)-17 inhibition. OBJECTIVES: To evaluate short-term efficacy of secukinumab in the management of axSpA. METHODS: Twenty-one patients (7 males, 14 females) with axSpA were consecutively treated with secukinumab. Laboratory and clinical assessments were based on erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), Ankylosing Spondylitis Disease Activity Score (ASDAS)-CRP, and Bath Ankylosing Spondylitis Disease Activity Index (BASDAI)...
July 2018: Israel Medical Association Journal: IMAJ
Hung-Wen Lai, Shou-Tung Chen, Shih-Lung Lin, Chih-Jung Chen, Ya-Ling Lin, Shu-Hsin Pai, Dar-Ren Chen, Shou-Jen Kuo
BACKGROUND: Experience with application of a robotic surgery platform in the management of breast cancer is limited. The preliminary results of the robotic nipple-sparing mastectomy (R-NSM) and immediate breast reconstruction (IBR) with Gel implant procedure are reported. METHODS: The medical records of patients from a single institution who underwent an R-NSM and IBR with Gel implant procedure for breast cancer during the period March 2017 to February 2018 were assessed...
August 14, 2018: Annals of Surgical Oncology
Cassandra Formeck, Agnieszka Swiatecka-Urban
Atypical hemolytic uremic syndrome (aHUS) is a rare and complex disease resulting from abnormal alternative complement activation with a wide range of clinical presentations. Extra-renal manifestations of aHUS can involve many organ systems, including the peripheral and central nervous, gastrointestinal, cardiovascular, integumentary, pulmonary, as well as the eye. While some of these extra-renal manifestations occur in the acute phase of aHUS, some can also occur as long-term sequelae of unopposed complement activation...
August 14, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
Katherine Smiley, Love Ofori, Cindy Spangler, Rebecca Acquaah-Arhin, Deborah Deh, Juliana Enos, Stephen Manortey, Frank Baiden, Samuel Finlayson, Raymond Price, Marta McCrum
BACKGROUND: The Volta River Authority Hospital (VRAH) is a district hospital associated with a large public works project in Akosombo, Ghana, that has developed a reputation for high-quality care. We hypothesized that this stems from a culture of safety and standardized processes typical of high-risk engineering environments. To investigate this, we evaluated staff and patient perceptions of safety and quality, as well as perioperative process variability. MATERIALS AND METHODS: The Safety Attitudes Questionnaire (SAQ) and Hospital Consumer Assessment of Healthcare Providers and Systems (HCAHPS) surveys were used to evaluate staff and patient perceptions of safety...
August 14, 2018: World Journal of Surgery
Shren Chetty, Kalai Naidu
Background: Africa is profoundly stricken by the HIV pandemic. People living with HIV/AIDS are more likely to be diagnosed with psychiatric disorders than the general population. We describe the prevalence of different mood and psychiatric disorders in HIV/AIDS infected patients with serious mental illness. Materials and Methods: We retrospectively sourced data from 105 patient files, at Weskoppies Hospital, between January 2012 and December 2016. Results: 56 patients had a psychotic disorder; 27 patients had a mood disorder and three patients had a cognitive disorder...
2018: African Journal of Infectious Diseases
Wei Liu, Qiang Wu, Xiao-Jie Yang, Jing Huang
Objective: To evaluate the trend of change in the efficacy and safety of catheter ablation compared with antiarrhythmic drug therapy (ADT) for rhythm control in patients with atrial fibrillation (AF) over time. Methods: The online databases PubMed and EMBASE were searched for relevant studies. STATA software (version 12.0) was used to perform the meta-analysis and meta-regression. Results: Fifteen randomized controlled trials including 2249 patients with AF were identified...
June 2018: Journal of Geriatric Cardiology: JGC
Ángel Borque-Fernando, José Rubio-Briones, Luis M Esteban, Yan Dong, Ana Calatrava, Álvaro Gómez-Ferrer, Enrique Gómez-Gómez, Jesús M Gil Fabra, Nuria Rodríguez-García, Pedro Á López González, Jorge García-Rodríguez, Miguel Rodrigo-Aliaga, Bernardo Herrera-Imbroda, Juan Soto-Villalba, Sara Martínez-Breijo, Virginia Hernández-Cañas, Ana M Soto-Poveda, Carlos Sánchez-Rodríguez, Carlos Carrillo-George, Yumaira E Hernández-Martínez, David Okrongly
BACKGROUND: Management of active surveillance (AS) in low-risk prostate cancer (PCa) patients could be improved with new biomarkers, such as the 4Kscore test. We analyze its ability to predict tumor reclassification by upgrading at the confirmatory biopsy at 6 months. METHODS: Observational, prospective, blinded, and non-randomized study, within the Spanish National Registry on AS (AEU/PIEM/2014/0001; NCT02865330) with 181 patients included after initial Bx and inclusion criteria: PSA ≤10 ng/mL, cT1c-T2a, Grade group 1, ≤2 cores, and ≤5 mm/50% length core involved...
August 14, 2018: Prostate Cancer and Prostatic Diseases
Hiroshi Itoh, Isao Kurihara, Kazutoshi Miyashita
In recent years, several post-interventional analyses of large-scale randomized controlled clinical trials have given us a new concept regarding the risk management of hypertension and cardiovascular diseases. The beneficial effects of intensive treatments were extended even after the interventions ended. This phenomenon is known as "metabolic memory" or "legacy effect", and we recognized its clinical significance. A certain level of evidence in human and animal studies employing organ transplantation techniques has indicated that this type of "memory" resides in each organ and could be transferrable, erasable, and rewritable, which is similar to neuronal and immune "memory"...
August 14, 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
Bhumika Aggarwal, Aruni Mulgirigama, Norbert Berend
Exercise-induced bronchoconstriction (EIB) can occur in individuals with and without asthma, and is prevalent among athletes of all levels. In patients with asthma, symptoms of EIB significantly increase the proportion reporting feelings of fearfulness, frustration, isolation, depression and embarrassment compared with those without symptoms. EIB can also prevent patients with asthma from participating in exercise and negatively impact their quality of life. Diagnosis of EIB is based on symptoms and spirometry or bronchial provocation tests; owing to low awareness of EIB and lack of simple, standardised diagnostic methods, under-diagnosis and mis-diagnosis of EIB are common...
August 14, 2018: NPJ Primary Care Respiratory Medicine
Zach Rozenbaum, Yoav Granot, Arie Steinvil, Shmuel Banai, Ariel Finkelstein, Yanai Ben-Gal, Gad Keren, Yan Topilsky
BACKGROUND: Severe aortic stenosis (AS) and severe tricuspid regurgitation (TR) may coexist. The aim of this study was to determine the change in right ventricular (RV) function and TR after surgical aortic valve replacement combined with tricuspid valve repair (SAVR+TVr), transcatheter aortic valve replacement (TAVR), or conservative management and compare outcomes dependent on RV functional parameters and treatment allocation. METHODS: A retrospective analysis was conducted in 147 consecutive patients with severe AS and TR of baseline and 6-month clinical and echocardiographic parameters, including quantitative estimation of RV size and function (end-diastolic and end-systolic areas, tricuspid annular plane systolic excursion, fractional area change, and Tei index)...
August 11, 2018: Journal of the American Society of Echocardiography
Ethan J Rowin, Barry J Maron, Aalap Chokshi, Muhil Kannappan, Knarik Arkun, Wendy Wang, Hassan Rastegar, Martin S Maron
Hypertrophic cardiomyopathy (HC) has historically been characterized as a disease of substantial left ventricular hypertrophy, often associated with dynamic left ventricular outflow tract obstruction. However, we have recently encountered patients with subaortic obstruction and only minimal basal septal thickness, raising important management implications. Thereby, we sought to characterize the natural history and treatment strategies for this under-recognized subgroup of HC patients with dynamic obstruction...
July 17, 2018: American Journal of Cardiology
Yizhou Zhao, Mathieu Castonguay, Derek Wilke, Zhaolin Xu, Madelaine Plourde, Liam Mulroy, Mary MacNeil, David Bowes
INTRODUCTION: Large cell neuroendocrine carcinoma (LCNEC) is a rare type of high-grade pulmonary neuroendocrine tumor. The study objective is to investigate its survival outcomes, incidence of brain metastases, and patterns of recurrence. METHODS: This is a single center study of patients with pathologic diagnosis of pulmonary LCNEC. Patient data were collected retrospectively and analyzed, including survival, incidence of brain metastases, and patterns of recurrence...
May 24, 2018: Current Problems in Cancer
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