keyword
https://read.qxmd.com/read/38508668/inhaled-versus-systemic-corticosteroids-for-acute-exacerbations-of-copd-a-systematic-review-and-meta-analysis
#21
REVIEW
Efthymia Papadopoulou, Sulaiman Bin Safar, Ali Khalil, Jan Hansel, Ran Wang, Alexandru Corlateanu, Konstantinos Kostikas, Stavros Tryfon, Jørgen Vestbo, Alexander G Mathioudakis
This meta-analysis compares the efficacy and safety of inhaled versus systemic corticosteroids for COPD exacerbations.Following a pre-registered protocol, we appraised eligible randomised controlled trials (RCTs) according to Cochrane methodology, performed random-effects meta-analyses for all outcomes prioritised in the European Respiratory Society COPD core outcome set and rated the certainty of evidence as per Grading of Recommendations Assessment, Development and Evaluation methodology.We included 20 RCTs totalling 2140 participants with moderate or severe exacerbations...
January 31, 2024: European Respiratory Review: An Official Journal of the European Respiratory Society
https://read.qxmd.com/read/38508342/musculoskeletal-crosstalk-in-chronic-obstructive-pulmonary-disease-and-comorbidities-emerging-roles-and-therapeutic-potentials
#22
REVIEW
Kevin Mou, Stanley M H Chan, Ross Vlahos
Chronic Obstructive Pulmonary Disease (COPD) is a multifaceted respiratory disorder characterized by progressive airflow limitation and systemic implications. It has become increasingly apparent that COPD exerts its influence far beyond the respiratory system, extending its impact to various organ systems. Among these, the musculoskeletal system emerges as a central player in both the pathogenesis and management of COPD and its associated comorbidities. Muscle dysfunction and osteoporosis are prevalent musculoskeletal disorders in COPD patients, leading to a substantial decline in exercise capacity and overall health...
March 18, 2024: Pharmacology & Therapeutics
https://read.qxmd.com/read/38507607/the-effect-of-chronic-altitude-exposure-on-copd-outcomes-in-the-spiromics-cohort
#23
JOURNAL ARTICLE
Rajat Suri, Daniela Markovic, Han Woo, Mehrdad Arjomandi, R Graham Barr, Russell P Bowler, Gerard Criner, Jeffrey L Curtis, Mark T Dransfield, M Bradley Drummond, Spyridon Fortis, MeiLan K Han, Eric A Hoffman, Robert J Kaner, Joel D Kaufman, Jerry A Krishnan, Fernando J Martinez, Jill Ohar, Victor E Ortega, Robert Paine Iii, Xavier Soler, Prescott G Woodruff, Nadia N Hansel, Christopher B Cooper, Donald P Tashkin, Russell G Buhr, Igor Z Barjaktarevic
RATIONALE: Individuals with COPD have airflow obstruction and maldistribution of ventilation. For those living at high altitude, any gas exchange abnormality is compounded by reduced partial pressures of inspired oxygen. OBJECTIVES: Does residence at higher-altitude exposure affect COPD outcomes, including lung function, imaging characteristics, symptoms, health status, functional exercise capacity, exacerbations, or mortality? METHODS: From the SPIROMICS cohort, we identified individuals with COPD living below 1,000 ft (305 m) elevation (n= 1,367) versus above 4,000 ft (1,219 m) elevation (n= 288)...
March 20, 2024: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/38505074/differential-response-to-roflumilast-in-patients-with-chronic-obstructive-pulmonary-disease-real-world-evidence
#24
JOURNAL ARTICLE
Hyun Woo Lee, Jiyu Sun, Hyo-Jin Lee, Jung-Kyu Lee, Tae Yeon Park, Eun Young Heo, Chin Kook Rhee, Deog Kyeom Kim
BACKGROUND: Roflumilast is effective in reducing acute exacerbation in patients with chronic obstructive pulmonary disease (COPD) at high risk of severe exacerbation. Clinical traits related to the benefits of roflumilast need to be evaluated in patients with COPD. METHODS: A longitudinal observational study in patients newly diagnosed with COPD was conducted using claims data from the Health Insurance Review and Assessment Service in South Korea from 2012-2020 after a 2-year washout period...
February 29, 2024: Journal of Thoracic Disease
https://read.qxmd.com/read/38505044/a-comparison-of-gold-2019-and-2023-recommendations-to-contemporaneous-real-world-inhaler-treatment-patterns-for-chronic-obstructive-pulmonary-disease-management-in-singapore
#25
JOURNAL ARTICLE
Rayan Alsuwaigh, Anthony Yii, Chee Hong Loh, Xiaomeng Xu, Priti Bahety, Aldo A Navarro Rojas, Dominique Milea, Augustine Tee
BACKGROUND: In 2019 and 2023, the Global Initiative for Chronic Obstructive Lung Disease (GOLD) provided updated strategies for modifying the therapy of patients with chronic obstructive pulmonary disease (COPD) and high exacerbation risk. A key update since the 2019 guidelines recommends considering blood eosinophil count to guide decisions on inhaled corticosteroid (ICS) treatment. To evaluate the potential impact of these updated recommendations, this study aimed to assess how extensively future practice would diverge from contemporaneous prescribing practices at a single center in Singapore, assuming adherence to the 2019 and 2023 GOLD guidelines...
February 29, 2024: Journal of Thoracic Disease
https://read.qxmd.com/read/38503629/efficacy-of-nemiralisib-in-chronic-obstructive-pulmonary-disease-a-systematic-review
#26
REVIEW
Hongkuan Yang, Shuifeng He, Linbao Liang, Junjie Pan
PURPOSE: Chronic obstructive pulmonary disease (COPD) is a major public health concern. Exacerbation of COPD leads to poor health and frequent episodes of increased systemic and airway inflammation. Immunomodulatory drugs have garnered extensive attention because they may reduce the rate of COPD exacerbation. This review aimed to evaluate the efficacy and safety of nemiralisib in COPD patients. METHODS: Medical databases, including the Cochrane Library, EMBASE, and PubMed, were queried from inception to June 2023 to identify randomized controlled trials (RCTs) on the efficacy of nemiralisib in COPD patients...
March 18, 2024: Clinical Therapeutics
https://read.qxmd.com/read/38503466/review-of-the-evidence-for-pulmonary-rehabilitation-in-copd-clinical-benefits-and-cost-effectiveness
#27
JOURNAL ARTICLE
Courtney E Lamberton, Christopher L Mosher
COPD is a common and lethal chronic condition, recognized as a leading cause of death worldwide. COPD is associated with significant morbidity and disability, particularly among older adults. The disease course is marked by periods of stability and disease exacerbations defined by worsening respiratory status resulting in a high burden of health care utilization and an increased risk of mortality. Treatment is focused on pharmacologic therapies, but these are not completely effective. Pulmonary rehabilitation (PR) represents a key medical intervention for patients with chronic respiratory diseases, including COPD...
March 19, 2024: Respiratory Care
https://read.qxmd.com/read/38503465/pulmonary-rehabilitation-mechanisms-of-functional-loss-and-benefits-of-exercise
#28
JOURNAL ARTICLE
Linda Nici
Exercise limitation is a characteristic feature of chronic respiratory diseases such as COPD and is associated with poor outcomes including decreased functional status and health-related quality of life and increased mortality. The mechanisms responsible for exercise limitation are complex and include ventilatory limitation, cardiovascular impairment, and skeletal muscle dysfunction. In addition, comorbidities such as cardiovascular disease are common in this population and can further impact exercise capacity...
March 19, 2024: Respiratory Care
https://read.qxmd.com/read/38502541/rsv-related-community-copd-exacerbations-and-novel-diagnostics-a-binational-prospective-cohort-study
#29
JOURNAL ARTICLE
Dexter J Wiseman, Ryan S Thwaites, Andrew I Ritchie, Lydia Finney, Mairi Macleod, Faisal Kamal, Hassan Shahbakhti, Lisa H van Smoorenburg, Huib A Kerstjens, Joanne Wildenbeest, Deniz Öner, Jeroen Aerssens, Guy Berbers, Rutger Schepp, Ashley Uruchurtu, Benedikt Ditz, Louis Bont, James P Allinson, Maarten van den Berge, Gavin C Donaldson, Peter J Openshaw, Jadwiga Wedzicha
RATIONALE: Respiratory syncytial virus (RSV) is a common global respiratory virus increasingly recognized as a major pathogen in frail older adults and as a cause of chronic obstructive pulmonary disease (COPD) exacerbations. There is no single test for RSV in adults with acceptable diagnostic accuracy. Trials of RSV vaccines have recently shown excellent safety and efficacy against RSV in older adults; defining the frequency of RSV-related community infections and COPD exacerbations is important for vaccine deployment decisions...
March 19, 2024: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/38502239/risk-of-cardiovascular-events-after-acute-exacerbations-of-chronic-obstructive-pulmonary-disease-in-patients-receiving-long-term-low-dose-azithromycin
#30
JOURNAL ARTICLE
Tommaso Bucci, Dennis Wat, Dilip Nazareth, Sarah Sibley, Dan Wootton, Gregory Yh Lip, Freddy Frost
No abstract text is available yet for this article.
March 19, 2024: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/38500792/copd-assessment-test-and-risk-of-readmission-in-patients-with-bronchiectasis-a-prospective-cohort-study
#31
JOURNAL ARTICLE
Juan Wang, Xiaoting Chen, Siqi He, Jing Li, Tianyuan Ma, Lu Liu, Lei Zhang, Xiaoning Bu
INTRODUCTION: Readmission following bronchiectasis exacerbation is a common and challenging clinical problem and few simple predictive tools exist. The COPD Assessment Test (CAT) is an easy-to-use questionnaire. This study aims to evaluate the predictive value of CAT scores in determining the risk of readmission in patients with bronchiectasis exacerbation. METHODS: We conducted a prospective cohort study in 106 bronchiectasis patients admitted with exacerbation...
March 2024: ERJ Open Research
https://read.qxmd.com/read/38500152/characteristics-associated-with-sf-36-in-alpha-1-antitrypsin-deficiency-associated-copd-a-cross-sectional-analysis
#32
JOURNAL ARTICLE
Radmila Choate, Kristen E Holm, Robert A Sandhaus, David M Mannino, Charlie Strange
BACKGROUND: Generic measures of health-related quality of life (HRQoL), such as the 36-Item Short Form Survey (SF-36), are widely used in assessing chronic conditions. These tools have an advantage over disease-specific instruments, as they allow comparisons across different health conditions and with the general population. In alpha-1 antitrypsin deficiency (AATD)-associated chronic obstructive pulmonary disease (COPD), HRQoL research remains scarce. This cross-sectional study evaluates the factors associated with HRQoL in a cohort of patients with AATD-associated COPD...
March 18, 2024: BMC Pulmonary Medicine
https://read.qxmd.com/read/38499651/prediction-model-and-assessment-of-malnutrition-in-patients-with-stable-chronic-obstructive-pulmonary-disease
#33
JOURNAL ARTICLE
Xurui Shen, Ruiqi Qian, Yuan Wei, Zhichao Tang, Huafei Zhong, Jianan Huang, Xiuqin Zhang
Chronic obstructive pulmonary disease (COPD) combined with malnutrition results in decreased exercise capacity and a worse quality of life. We aimed to develop an observational case-control study to explore the effective and convenient method to identify potential individuals is lacking. This study included data from 251 patients with COPD and 85 participants in the control group. Parameters and body composition were compared between groups, and among patients with varied severity. The LASSO approach was employed to select the features for fitting a logistic model to predict the risk of malnutrition in patients with stable COPD...
March 18, 2024: Scientific Reports
https://read.qxmd.com/read/38499274/dynamic-hyperinflation-is-a-risk-factor-for-mortality-and-severe-exacerbations-in-copd-patients
#34
JOURNAL ARTICLE
Isabel Lorenzana, Raúl Galera, Raquel Casitas, Elisabet Martínez-Cerón, María Alejandra Castillo, Enrique Alfaro, Carolina Cubillos-Zapata, Francisco García-Río
OBJECTIVE: To assess if dynamic hyperinflation is an independent risk factor for mortality and severe exacerbations in COPD patients. METHODS: A cohort of 141 patients with stable COPD and moderate to very severe airflow limitation, treated according to conventional guidelines, was followed for a median of 9 years. Clinical characteristics were recorded and arterial blood gases, pulmonary function tests, 6-min walk and incremental exercise test with measurement of respiratory pattern and operative lung volumes were performed...
March 16, 2024: Respiratory Medicine
https://read.qxmd.com/read/38497202/gaining-insights-into-chronic-obstructive-pulmonary-disease-exacerbation-through-emerging-biomarkers-and-the-chronic-obstructive-pulmonary-disease-assessment-test-score
#35
JOURNAL ARTICLE
Megha Hegde, Saurav Raj, Aishwarya S Pattanshetti, Sanatkumar Bharamu Nyamagoud
Chronic obstructive pulmonary disease (COPD), a leading cause of mortality and morbidity, presents significant challenges, particularly with exacerbations, which drastically impact patients' health and healthcare costs. The Global Initiative for Chronic Obstructive Lung Disease guidelines recommend comprehensive assessments beyond spirometry, with the COPD assessment test (CAT) emerging as a pivotal tool. Despite its utility, the relationship between CAT scores and specific biomarkers during exacerbations remains unclear...
March 14, 2024: Monaldi Archives for Chest Disease
https://read.qxmd.com/read/38495475/kynurenine-pathway-in-respiratory-diseases
#36
REVIEW
Guillaume Pamart, Philippe Gosset, Olivier Le Rouzic, Muriel Pichavant, Odile Poulain-Godefroy
The kynurenine pathway is the primary route for tryptophan catabolism and has received increasing attention as its association with inflammation and the immune system has become more apparent. This review provides a broad overview of the kynurenine pathway in respiratory diseases, from the initial observations to the characterization of the different cell types involved in the synthesis of kynurenine metabolites and the underlying immunoregulatory mechanisms. With a focus on respiratory infections, the various attempts to characterize the kynurenine/tryptophan (K/T) ratio as an inflammatory marker are reviewed...
2024: International Journal of Tryptophan Research: IJTR
https://read.qxmd.com/read/38495215/efficacy-of-acupuncture-in-acute-exacerbation-of%C3%A2-chronic-obstructive-pulmonary-disease-a-systematic-review-and-meta-analysis
#37
REVIEW
Chunyan Yang, Hao Tian, Guixing Xu, Qin Luo, Mingsheng Sun, Fanrong Liang
PURPOSE: The effect of acupuncture as adjunctive therapy for acute exacerbation of chronic obstructive pulmonary disease (AECOPD) was controversial. Thus, we aimed to evaluate the effects of acupuncture for treating AECOPD. METHODS: Eight databases were searched from database inception to July 30, 2023. All RCTs compared acupuncture plus conventional western medicine with conventional western medicine alone were included. Outcomes were quality of life, lung function, blood oxygen condition, exercise capacity, daily symptoms, duration of hospitalization, and adverse events...
2024: International Journal of Chronic Obstructive Pulmonary Disease
https://read.qxmd.com/read/38490695/characteristics-and-phenotypes-of-a-copd-cohort-from-referral-hospital-clinics-in-uganda
#38
JOURNAL ARTICLE
Patricia Alupo, Levicatus Mugenyi, Winceslaus Katagira, Alex Kayongo, Joanitah Nalunjogi, Trishul Siddharthan, John R Hurst, Bruce Kirenga, Rupert Jones
INTRODUCTION: Chronic obstructive pulmonary disease (COPD) is a heterogeneous condition with varied clinical and pathophysiological characteristics. Although there is increasing evidence that COPD in low-income and middle-income countries may have different clinical characteristics from that in high-income countries, little is known about COPD phenotypes in these settings. We describe the clinical characteristics and risk factor profile of a COPD population in Uganda. METHODS: We cross sectionally analysed the baseline clinical characteristics of 323 patients with COPD aged 30 years and above who were attending 2 national referral outpatient facilities in Kampala, Uganda between July 2019 and March 2021...
March 15, 2024: BMJ Open Respiratory Research
https://read.qxmd.com/read/38488853/efficacy-and-safety-of-once-daily-vilanterol-fluticasone-furoate-mdi-in-persistent-asthma-phase-3-od-inhale-study
#39
JOURNAL ARTICLE
Avdhesh Kumar, Manish Kumar Jain, Vijaykumar Bhagwan Barge, Raghumanda Sunil Kumar, Neeraj Gupta, Harendra Yadav, Amitava Pal, Vivek Eknath Redkar, Asish Mondal, Rahul Kumar Rathore, Pavankumar Daultani, Ashok Jaiswal, Ravi T Mehta
Introduction: Once-daily inhalers have been shown to improve adherence leading to lesser discontinuation compared to twice- or thrice-daily inhalers in management of asthma. Combination of Vilanterol and Fluticasone Furoate (VI/FF) is approved for management of asthma and COPD and is available as a dry powder inhaler. Pressurized-Metered Dose Inhalers (pMDIs) offer ease-of-use and therapy alternatives for patients with low inspiratory flow. This study assessed the efficacy and safety of a new once-daily pMDI containing VI/FF in individuals diagnosed with persistent asthma...
March 15, 2024: Journal of Asthma
https://read.qxmd.com/read/38487534/immunoproteomics-enable-broad-identification-of-new-aspergillus-fumigatus-antigens-in-severe-equine-asthma
#40
JOURNAL ARTICLE
Maria-Christin Jentsch, Sabrina Lübke, Wieland Schrödl, Daniela Volke, Andor Krizsan, Ralf Hoffmann, Sarah Kaiser-Thom, Vinzenz Gerber, Eliane Marti, Bettina Wagner, Christiane L Schnabel
INTRODUCTION: Severe equine asthma (SEA) is a common chronic disease of adult horses with characteristic recurrent airway obstruction and similarities to neutrophilic asthma in humans. As an extrinsic stimulus, hay dust exposure is a major risk factor and induces acute exacerbation in susceptible horses. However, single inducing agents of SEA have hardly been identified on a molecular basis. Aspergillus fumigatus ( A. fumigatus ) is a common mold species in hay and has been described as a major provoking agent of SEA...
2024: Frontiers in Immunology
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