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Copd exacerbations

Stephen Milne, Don D Sin
No abstract text is available yet for this article.
August 14, 2018: Respirology: Official Journal of the Asian Pacific Society of Respirology
Wassim W Labaki, MeiLan K Han
No abstract text is available yet for this article.
2018: International Journal of Chronic Obstructive Pulmonary Disease
Marco Mantero, Dejan Radovanovic, Pierachille Santus, Francesco Blasi
The major determinant of the decline in lung function, quality of life, and the increased mortality risk in patients with COPD is represented by severe acute exacerbations of the disease, that is, those requiring patients' hospitalization, constituting a substantial social and health care burden in terms of morbidity and medical resource utilization. Different long-term therapeutic strategies have been proposed so far in order to prevent and/or reduce the clinical and social impact of these events, the majority of which were extrapolated from trials initially focused on the effect of long-acting muscarinic antagonist and subsequently on the efficacy of long-acting β2-agonists in combination or not with inhaled corticosteroids...
2018: International Journal of Chronic Obstructive Pulmonary Disease
Adam J Białas, Paweł P Liberski, Anna Zielińska, Anna Kumor-Kisielewska, Karolina Szewczyk, Joanna Miłkowska-Dymanowska, Przemysław Sitarek, Wojciech J Piotrowski, Paweł Górski
Introduction: Exacerbations of chronic obstructive pulmonary disease (ECOPD) are important events in the course of the disease, negatively influencing health status and disease progression. Therefore, there is a strong need for deeper understanding of the pathology of ECOPD to elaborate new therapeutic approaches and ameliorate prognoses. Contributions of mitochondria to pathobiology of COPD are still under investigation, although growing evidence suggests their important role in this disease...
2018: International Journal of Chronic Obstructive Pulmonary Disease
Jeetvan G Patel, Anna D Coutinho, Orsolya E Lunacsek, Anand A Dalal
Purpose: This study aimed to measure the true burden of COPD by calculating incremental direct and indirect costs. Direct medical resource use, productivity metrics, and COPD-specific resource use and costs were also evaluated. Patients and methods: This was a retrospective, observational, matched cohort study using administrative claims data from the Truven Health MarketScan® Commercial Claims and Encounters and the Health and Productivity Management databases (2007-2010)...
2018: International Journal of Chronic Obstructive Pulmonary Disease
Jose Luis Lopez-Campos, Bernardino Alcázar Navarrete, Joan B Soriano, Juan J Soler-Cataluña, José Miguel Rodríguez González-Moro, Manuel E Fuentes Ferrer, Myriam Calle Rubio
Purpose: Current COPD management recommendations indicate that pharmacological treatment can be stepped up or down, but there are no recommendations on how to make this adjustment. We aimed to describe pharmacological prescriptions during a routine clinical visit for COPD and study the determinants of changing therapy. Methods: EPOCONSUL is a Spanish nationwide observational cross-sectional clinical audit with prospective case recruitment including 4,508 COPD patients from outpatient respiratory clinics for a period of 12 months (May 2014-May 2015)...
2018: International Journal of Chronic Obstructive Pulmonary Disease
Swati Gulati, Aline N Zouk, Jonathan P Kalehoff, Christopher S Wren, Peter N Davison, Denay Porter Kirkpatrick, Surya P Bhatt, Mark T Dransfield, James Michael Wells
Background: Systemic corticosteroids (SC) are an integral part of managing acute exacerbations of COPD (AECOPD). However, the optimal dose and duration vary widely in clinical practice. We hypothesized that the use of a "PowerPlan" order set in the electronic health system (EHS) that includes a 5-day SC order would be associated with a reduced steroid dose and length of stay (LOS) for individuals hospitalized with AECOPD. Patients and methods: We conducted a retrospective cohort study of Medicare recipients discharged with an AECOPD diagnosis from our University Hospital from 2014 to 2016...
2018: International Journal of Chronic Obstructive Pulmonary Disease
Yong Suk Jo, Yee Hyung Kim, Jung Yeon Lee, Kyungjoo Kim, Ki-Suck Jung, Kwang Ha Yoo, Chin Kook Rhee
Background and objective: The rate of obesity is increasing in Asia, but the clinical impact of body mass index (BMI) on the outcome of chronic obstructive pulmonary disease (COPD) remains unknown. We aimed to assess this impact while focusing on the risk of exacerbation, health-care utilization, and medical costs. Methods: We examined 43,864 subjects registered in the Korean National Health and Nutrition Examination Survey (KNHANES) database from 2007 to 2012, and linked the data of COPD patients who had mild to moderate airflow obstruction (n = 1,320) to National Health Insurance (NHI) data...
2018: International Journal of Chronic Obstructive Pulmonary Disease
Xiaoyan Chen, Jinguo Liu, Mengchan Zhu, Bijie Hu, Fengxi Bai, Wenting Jin, Jian Zhou, Cuicui Chen, Yuanlin Song, Jue Pan
BACKGROUND: Progranulin is a pleiotropic glycosylated protein precursor that plays an important role in inflammation. Limited data exist regarding the role of progranulin in the acute exacerbation of chronic obstructive pulmonary disease (AECOPD). OBJECTIVES: The study is to assess the efficiency of progranulin as a circulating biomarker of AECOPD. METHODS: The plasma progranulin levels were measured and compared in patients with AECOPD (n = 52), patients with stable COPD (n = 56) and healthy controls (n = 36)...
August 12, 2018: Clinical Respiratory Journal
Jeffrey Thiboutot, Wu Yuan, Hyeon-Cheol Park, Andrew D Lerner, Wayne Mitzner, Lonny B Yarmus, Xingde Li, Robert H Brown
OBJECTIVE: To review the recent advances in available technologies for imaging COPD and present the novel optical coherence tomography (OCT) airway imaging technology. MATERIALS AND METHODS: This is an unstructured review of published evidence of available pulmonary imaging technologies along with a demonstration of state-of-the-art OCT imaging technology of in vivo human and animal airways. RESULTS: Advanced imaging techniques such as Magnetic Resonance (MR) imaging using hyperoloarized noble gases, micro-Computed Tomography (micro-CT), and OCT aim to further our understanding of COPD...
August 6, 2018: Academic Radiology
Marc Miravitlles
No abstract text is available yet for this article.
August 9, 2018: American Journal of Respiratory and Critical Care Medicine
A Wilke, H Semper, C Gross, C Grohé
BACKGROUND: Augmentation with human alpha-1 proteinase inhibitor is the only specific treatment for Alpha-1-Antitrypsin Deficiency (AATD), a rare genetic disease with symptoms of progressive COPD. OBJECTIVES: A prospective long-term exploration of outcomes during the "Alpha-1-Mobile" home care AAT augmentation program in seven advanced-stage patients. METHODS: Patients received weekly i. v. AAT augmentation and COPD therapy. Symptoms, lung function, health status, quality-of-life aspects, and safety were documented continuously...
August 2018: Pneumologie
Feruza Turan Sönmez, Recep Eröz
Objective To investigate whether argyrophilic nucleolar organizing region-associated protein (AgNOR) parameters can be used as a biomarker that could potentially help with the management and clinical prognosis of chronic obstructive pulmonary disease (COPD) exacerbation. Methods This case-control study enrolled patients with COPD who were admitted to the Emergency Department and healthy sex- and age-matched control subjects. Peripheral blood samples were collected at hospital admission and the peripheral lymphocytes were silver-stained to investigate the quantity and distribution of AgNOR proteins...
August 8, 2018: Journal of International Medical Research
Byeong Gon Kim, Pureun Haneul Lee, Sun Hye Lee, Ae Rin Baek, Jong Sook Park, Junehyuk Lee, Sung Woo Park, Do Jin Kim, Choon Sik Park, An Soo Jang
PURPOSE: The tight junction protein claudin-5 (CLDN5) is critical to the control of endothelial cellular polarity and pericellular permeability. The role of CLDN5 in chronic obstructive pulmonary disease (COPD) remains unclear. The aim of this study was to investigate the association between CLDN5 levels and clinical variables in patients with COPD. METHODS: In total, 30 patients with COPD and 30 healthy controls were enrolled in the study. The plasma CLDN5 level was checked in patients with stable or exacerbated COPD and in healthy controls...
September 2018: Allergy, Asthma & Immunology Research
Elisenda Gómez-Angelats, Carolina Sánchez
Chronic obstructive pulmonary disease (COPD) is the second leading cause of emergency department (ED) admissions to hospital, and nearly a third of patients with acute exacerbation (AE) of COPD are re-admitted to hospital within 28 days after discharge. It has been suggested that nearly a third of COPD admissions could be avoided through the implementation of evidence-based care interventions. A COPD discharge bundle is a set of evidence-based practices, aimed at improving patient outcomes after discharge from AE COPD; body of evidence supports the usefulness of discharge care bundles after AE of COPD, although there is a lack of consensus of what interventions should be implemented...
August 7, 2018: Medical Sciences: Open Access Journal
Yochai Adir, Omar Hakrush, Michal Shteinberg, Sonia Schneer, Alvar Agusti
Whether the level of circulating eosinophils in chronic obstructive pulmonary disease (COPD) patients can predict the risk of exacerbations of COPD (ECOPD) or response to treatment is debated. Here, we evaluate the prevalence of elevated eosinophils in COPD patients and its relationship with severe ECOPD requiring hospitalisation. We retrospectively reviewed the charts of COPD patients hospitalised in our centre between January 1, 2005 and November 30, 2015 because of ECOPD or other reasons (controls). In a second analysis, the ECOPD patients were divided into two subgroups based on having ECOPD in the next year after the index event or not...
July 2018: ERJ Open Research
Songül Özyurt, Bilge Yılmaz Kara, Neslihan Özçelik, Ünal Şahin
OBJECTIVES: Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) are major components of COPD-related socioeconomic burden. Upper or lower respiratory tract infections, usually caused by respiratory viruses or bacteria, are common causes of AECOPD. Vaccination aganist influenza virus and Streptoccus pneumoniae , the most prevalent agents, is recommended by COPD guidelines. The aims of this study were to determine the factors affecting vaccination among patients with COPD and to assess the effect of vaccination status on AECOPD...
July 2018: Turkish Thoracic Journal
Ingela Henoch, Claes-Göran Löfdahl, Ann Ekberg-Jansson
Introduction : Chronic obstructive pulmonary disease (COPD) contributes to impaired health-related quality of life (HRQoL). Patient education and smoking cessation programs are recommended to reduce the number of exacerbations and hospitalizations, but the effects of such programs have yet to be explored in larger samples. Objective : The aim was to explore the longitudinal effects of patient education and smoking cessation programs on exacerbations and hospital admissions in patients with COPD. Design : This is a register study where data from the Swedish National Airway Register, including 20,666 patients with COPD, were used...
2018: European Clinical Respiratory Journal
E V Bolotova, V V Yavlyanskaya, A V Dudnikova
The aim of the study was to examine the relationship of vitamin D levels with markers of cardiorenal syndrome in patients with COPD depending on the severity of bronchial obstruction.198 patients with COPD were divided into 2 groups depending on the severity of bronchial obstruction. A deficiency of vitamin D was significantly more prevalent in COPD patients with GFRcys <60 ml/min/1,73 m2 compared to patients with preserved renal function. A medium positive correlation of vitamin D levels with the severity of bronchial obstruction (r=0,419, p=0,001), medium negative correlation of vitamin D levels with exacerbation frequency (r=0,421, p=0,01) and CRP (r=0,301, p=0,02) were observed...
2018: Advances in Gerontology, Uspekhi Gerontologii
Laura J Spece, Eric M Epler, Lucas M Donovan, Matthew F Griffith, Margaret P Collins, Laura C Feemster, David H Au
RATIONALE: Hospital readmissions are an important cause of morbidity and mortality among patients with COPD. While comorbidities are associated with outcomes in COPD, it is unknown how they affect treatment choices. OBJECTIVE: We sought to examine whether comorbidity was associated with readmission, mortality, and delivery of in-hospital treatment for COPD exacerbations. METHODS: We performed a cohort study of veterans hospitalized with a COPD exacerbation to six Veterans Affairs hospitals between 2005-2011...
August 4, 2018: Annals of the American Thoracic Society
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