Federica Baffetta, Cecilia Buonsanti, Luca Moraschini, Susanna Aprea, Martina Canè, Stefano Lombardi, Mario Contorni, Simona Rondini, Ashwani Kumar Arora, Monia Bardelli, Oretta Finco, Davide Serruto, Silvia Rossi Paccani
Chronic obstructive pulmonary disease (COPD) is a common chronic respiratory illness in older adults. A major cause of COPD-related morbidity and mortality is acute exacerbation of COPD (AECOPD). Bacteria in the lungs play a role in exacerbation development, and the most common pathogen is non-typeable Haemophilus influenzae (NTHi). A vaccine to prevent AECOPD containing NTHi surface antigens was tested in a clinical trial. This study measured IgG and IgA against NTHi vaccine antigens in sputum. Sputum samples from 40 COPD patients vaccinated with the NTHi vaccine were collected at baseline and 30 days after the second dose...
December 31, 2024: Human Vaccines & Immunotherapeutics