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https://www.readbyqxmd.com/read/30504351/adult-and-pediatric-mechanical-circulation-a-guide-for-the-hematologist
#1
REVIEW
Lisa Baumann Kreuziger, M Patricia Massicotte
Mechanical circulatory support (MCS) is the overarching term that encompasses the temporary and durable devices used in patients with severe heart failure. MCS disturbs the hematologic and coagulation system, leading to platelet activation, activation of the contact pathway of coagulation, and acquired von Willebrand syndrome. Ischemic stroke and major hemorrhage occur in up to 30% of patients. Hematologists are an essential part of the MCS team because they understand the delicate balance between bleeding and clotting and alteration of hemostasis with antithrombotic therapy...
November 30, 2018: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/30504337/evaluation-and-management-of-heavy-menstrual-bleeding-in-adolescents-the-role-of-the-hematologist
#2
REVIEW
Sarah H O'Brien
Heavy menstrual bleeding (HMB) is frequently reported by adolescents. The role of the hematologist is threefold in evaluating such patients: (1) perform a clinical and laboratory evaluation for an underlying bleeding disorder on the basis of the degree of clinical suspicion, (2) identify and manage any concomitant iron deficiency, and (3) provide input to the referring provider regarding the management of HMB, particularly for patients with identified hemostatic defects. Several clues in the menstrual history should raise suspicion for an underlying bleeding disorder, such as menses lasting >7 days, menstrual flow which soaks >5 sanitary products per day or requires product change during the night, passage of large blood clots, or failure to respond to conventional therapies...
November 30, 2018: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/30504296/approach-to-the-treatment-of-the-older-unfit-patient-with-myeloma-from-diagnosis-to-relapse-perspectives-of-a-us-hematologist-and-a-geriatric-hematologist
#3
REVIEW
Tanya M Wildes, Kenneth C Anderson
Mrs. A. is a 73-year-old woman who has developed increasing fatigue and lower back pain over the past year. The pain limits her exercise tolerance such that she can now walk only 1 block. She is a retired schoolteacher who does volunteer efforts in her community but has limited her activities due to fatigue. Karnofsky performance status is 70%. She has a history of chronic hypertension treated with a diuretic, adult-onset diabetes mellitus treated with metformin, and hypothyroidism treated with levothyroxine...
November 30, 2018: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/30504295/treatment-approach-for-the-older-unfit-patient-with-myeloma-from-diagnosis-to-relapse-perspectives-of-a-european-hematologist
#4
REVIEW
Thierry Facon, Kenneth Anderson
Mrs. A. is a 73-year-old woman who has developed increasing fatigue and lower back pain over the past year. The pain limits her exercise tolerance such that she can now walk only 1 block. She is a retired schoolteacher who does volunteer efforts in her community but has limited her activities due to fatigue. Karnofsky performance status is 70%. She has a history of chronic hypertension treated with a diuretic, adult-onset diabetes mellitus treated with metformin, and hypothyroidism treated with levothyroxine...
November 30, 2018: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/30504207/treating-childhood-acute-lymphoblastic-leukemia-in-a-country-with-no-pediatric-hematologist-oncologist-a-belize-m%C3%A3-rida-joint-venture
#5
Ellsworth Grant, Pablo González-Montalvo, Francisco Pantoja-Guillén, Gabriela Escamilla
No abstract text is available yet for this article.
November 30, 2018: Blood Advances
https://www.readbyqxmd.com/read/30487959/interaction-between-herpes-virus-infections-and-il10-and-risk-of-bone-marrow-suppression
#6
R Yaghobi, F Alizadeh, A Khodavandi
Background: Syndrome of transient bone marrow suppression may result from various extra-hematological diseases, such as immunological deregulations, and viral infectious diseases secondarily affecting the function of hematopoietic stem cells. Objective: To evaluate the pathogenic role of herpes viruses and their contraction with IL10 cytokine gene polymorphism, which can impair hematopoiesis in patients with transient bone marrow suppression. Methods: In a cross-sectional study 30 patients who admitted to Namazi Hospital, affiliated to Shiraz University of Medical Sciences, with transient bone marrow suppression were recruited...
2018: International Journal of Organ Transplantation Medicine
https://www.readbyqxmd.com/read/30485475/cutaneous-manifestations-of-hematologic-malignancies
#7
Giulia Merlo, Emanuele Cozzani, Filippo Canale, Maurizio Miglino, Massimiliano Gambella, Martina Burlando, Aurora Parodi
In recent years, dermatologic manifestations in oncohematologic patients have become more common. The aim of our study was to determine the incidence and heterogeneity of skin manifestations in patients followed at our Hematology Department. This observational monocentrical study was conducted on 60 patients. We divided the observed conditions in exanthematous, purpuric, vesicular-bullous, papulo-nodular, urticarial and eczematous manifestations. Moreover, all lesions were classified according to pathogenesis, in: (1) specific skin manifestations, caused by neoplastic skin infiltration; (2) immune-mediated manifestations, based on immunological mechanisms; (3) skin lesions due to immunodeficiency...
November 28, 2018: Hematological Oncology
https://www.readbyqxmd.com/read/30473467/flow-cytometry-and-immune-thrombocytopenic-purpura
#8
REVIEW
Hadi Goubran, Caroline Hart, Ibraheem Othman, Jerard Seghatchian
Although Immune thrombocytopenic purpura is a common disorder that family physicians, internists and hematologists face in their everyday practice, its diagnosis rests only on "exclusion" and its therapy is based on algorithms where "trial and error" is the rule. Flow cytometry, if simplified and standardized, could provide a quicker and better diagnostic accuracy. Studies of the lymphocyte subset using flow cytometry and more elaborate immune studies are paving the way for a better understanding of the disease and in identification of prognostic markers...
October 30, 2018: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/30459131/current-approach-to-early-gastrointestinal-and-liver-complications-of-hematopoietic-stem-cell-transplantation
#9
Erden Atilla, Pınar Ataca Atilla, Güldane Cengiz Seval, Mehmet Bektaş, Taner Demirer
The gastrointestinal (GI) system is one of the most commonly affected sites during a hematopoietic stem cell transplantation (HSCT) due to toxicities of preparative regimens, the accompanying immunodeficiency, and organ damage caused by graft versus host disease. In this review, we focus on early GI and liver complications following autologous (auto-) and allogeneic (allo-) HSCT and clarify both the risk factors and therapeutic strategies. Early GI and liver complications associated with HSCT remain challenging issues...
November 19, 2018: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
https://www.readbyqxmd.com/read/30451209/leukostasis-retinopathy-an-uncommon-visual-threatening-complication-of-chronic-myeloid-leukemia-with-severe-hyperleukocytosis-a-case-report-and-review-of-the-literature
#10
Bo Chen, Xiaoqin Yan, Xian Zhang, Hong Yang
To describe a rare case of an unusual visual threatening complication of chronic myeloid leukemia (CML). A 21-year-old male visited the hospital complaining of 1-week painless binocular acute visual loss without any other symptoms. The patient was diagnosed with CML. He then received emergent leukapheresis with imatinib treatment, which achieved obvious hematological remission. However, the visual acuity did not recover along with the CML remission and ocular structure relief. CML-related leukostasis could induce severe leukostasis retinopathy...
December 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/30429157/evaluation-and-management-of-heavy-menstrual-bleeding-in-adolescents-the-role-of-the-hematologist
#11
Sarah H O'Brien
Heavy menstrual bleeding (HMB) is frequently reported by adolescents. The role of the hematologist is threefold in the evaluation of such patients: 1) perform a clinical and laboratory evaluation for an underlying bleeding disorder based on the degree of clinical suspicion, 2) identify and manage any concomitant iron deficiency, and 3) provide input to the referring provider regarding the management of HMB, particulary for patients with identified hemostatic defects. Several clues in the menstrual history should raise suspicion for an underlying bleeding disorder, such as menses lasting >7 days, menstrual flow which soaks >5 products daily or requires product change during the night, passage of large blood clots, or failure to respond to conventional therapies...
November 14, 2018: Blood
https://www.readbyqxmd.com/read/30409091/whatever-happened-to-the-shwartzman-phenomenon
#12
Abdullah B Chahin, Jason M Opal, Steven M Opal
Ninety years ago, Gregory Shwartzman first reported an unusual discovery following the intradermal injection of sterile culture filtrates from principally Gram-negative strains from bacteria into normal rabbits. If this priming dose was followed in 24 h by a second intravenous challenge (the provocative dose) from same culture filtrate, dermal necrosis at the first injection site would regularly occur. This peculiar, but highly reproducible, event fascinated the microbiologists, hematologists, and immunologists of the time, who set out to determine the mechanisms that underlie the pathogenesis of this reaction...
November 2018: Innate Immunity
https://www.readbyqxmd.com/read/30396506/-evaluation-of-management-disparity-in-patients-with-chronic-lymphocytic-leukemia-in-france
#13
Yann Rateau, Michael Harbouche, Gandhi Damaj, Xavier Troussard
Environmental factors have an impact on the effectiveness of treatments for chronic lymphocytic leukemia: vulnerability, organization of the supply of care and proximity of the patient to health professionals. The disparity of care was assessed; vulnerability by the European index of deprivation, the provision of care by values of localized potential accessibility to general practitioners, nurses and pharmacists and hospital supply by the density of hematologists and time access to the center. The data, extracted from the public databases for each grouped island for statistical information, were cross-referenced to apply a principal component analysis and group them into 4 clusters...
November 2, 2018: Bulletin du Cancer
https://www.readbyqxmd.com/read/30396479/oral-manifestations-in-stem-cell-transplantation-for-acute-myeloid-leukemia
#14
Alexandru Mester, Alexandra Irimie, Liana Oprita, Delia Dima, Bobe Petrushev, Ondine Lucaciu, Radu-Septimiu Campian, Alina Tanase
Acute myeloid leukemia is a highly aggressive malignancy with a high morbidity rate, for which an accurate and rapid diagnostic is essential. Acute myeloid leukemia manifestations frequently include oral abnormalities. Still, there is a limited number of studies reporting the incidence of oral manifestations in acute leukemia, the prevalence of periodontal status and periodontal parameters in these patients. Our aim was to emphasize the importance of early recognition by the dental practitioners of oral cavity manifestations as signs of acute myeloid leukemia, so that prompt referral to the hematologists is being done, and appropriate treatment is offered...
December 2018: Medical Hypotheses
https://www.readbyqxmd.com/read/30385205/oncofertility-what-can-we-do-from-bench-to-bedside
#15
Hua Zhao, Lei Jin, Yufeng Li, Cuilian Zhang, Renjie Wang, Yuehan Li, Weiming Huang, Chenchen Cui, Hanwang Zhang, Hui Wang, Ding Ma, Shujie Liao
Continuous improvement in diagnosis and treatment has significantly increased the survival of cancer patients. Treatments for neoplastic disease, including radiotherapy, chemotherapy, and surgery or combined therapy with the above methods, may lead to premature ovarian insufficiency (POI) or substantial male germ cell loss. For the patients it is a seriously double whammy. Therefore, reproductive medicine experts strongly suggest that all young patients diagnosed with a malignant tumor should immediately undergo a consultation with suggestions for fertility and endocrine function protection and preservation...
October 30, 2018: Cancer Letters
https://www.readbyqxmd.com/read/30384814/management-of-hemophagocytic-lympho-histiocytosis-in-critically-ill-patients
#16
Virginie Lemiale, Sandrine Valade, Laure Calvet, Eric Mariotte
Hemophagocytic syndrome remains a rare but life-threatening complication and is associated with intensive care unit (ICU) admission. The pathophysiology is based on a defect of cytotoxicity in T cells that results in a state of hyperinflammation in the presence of a trigger. As a consequence, patients may develop multiorgan failure. The diagnosis of hemophagocytic syndrome (HS) remains difficult and relies on persistant high-grade fevers in the absence of infection and on constellation of laboratory parameters...
November 1, 2018: Journal of Intensive Care Medicine
https://www.readbyqxmd.com/read/30374765/g-csf-guideline-adherence-in-germany-an-update-with-a-retrospective-and-representative-sample-survey
#17
Hartmut Link, Markus Kerkmann, Laura Holtmann, Petra Ortner
BACKGROUND: Current guidelines (GL) recommend neutropenia prophylaxis with G-CSF after chemotherapy (CTX) for patients with high (≥ 20%), or, if additional risk factors are present, intermediate (≥ 10-20%) risk of febrile neutropenia. The first sample survey in 2012 (NP1) showed lack of GL adherence. The aim of this second sample survey was to evaluate if GL adherence and implementation have improved. METHODS: The sample size represented 1.0% of the incidences of lung and 1...
October 29, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/30374757/-who-classification-of-myeloid-neoplasms
#18
REVIEW
C Wickenhauser
In 2014, two advisory committees (one each for myeloid and lymphoid neoplasms) of about 100 pathologists, hematologists, oncologists, and geneticists met in Chicago to revise the WHO diagnostic criteria. The goal was to define disease entities that should be modified, removed, or added based on new insights. In particular, to improve a biologically meaningful classification, a number of new molecular genetic markers were included, which had proved to be of diagnostic and/or prognostic relevance. The resulting differentiated diagnostic procedure is a challenge for the hematopathologist...
October 29, 2018: Der Pathologe
https://www.readbyqxmd.com/read/30373387/a-practical-guide-to-the-management-of-the-fetus-and-newborn-with-hemophilia
#19
Paul C Moorehead, Anthony K C Chan, Brigitte Lemyre, Rochelle Winikoff, Heather Scott, Sue Ann Hawes, Manohar Shroff, Aidan Thomas, Victoria E Price
Newborns with hemophilia are at risk of intracranial hemorrhage, extracranial hemorrhage, and other bleeding complications. The safe delivery of a healthy newborn with hemophilia is a complex process that can begin even before conception, and continues throughout pregnancy, birth, and the newborn period. This process involves the expectant parents and a wide variety of health-care professionals: genetic counselors, obstetricians, neonatologists, pediatricians, radiologists, adult and pediatric hematologists, and nurses with expertise in hemophilia...
October 29, 2018: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/30362247/how-i-approach-managing-student-athletes-at-risk-for-bleeding
#20
Char M Witmer
Frequently, pediatric hematologists need to provide guidance regarding sports participation for children with congenital coagulopathies, immune thrombocytopenia, and those receiving anticoagulation. Although sports participation has clear health and psychosocial benefits, it can be associated with harm secondary to bleeding from injury. Decision-making for sports involvement should be individualized, patient centered, and well informed. This review focuses on the current data regarding the benefit as well as risks for sports participation and provides a framework for advising and supporting the student athlete who is at risk for bleeding...
October 26, 2018: Pediatric Blood & Cancer
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