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Jinhua Jiang, Lu Lv, Shenggan Wu, Xuehua An, Feidi Wang, Xinju Liu, Xueping Zhao
Kresoxim-methyl (KM) is a broad spectrum strobilurin fungicide that has been used widely on crops around the world. In the present study, we aimed to investigate the toxic effects of KM using various sublethal endpoints during zebrafish (Danio rerio) larval development. Results showed that the LC50 values of KM to zebrafish at multiple life stages (embryo, larvae, juvenile and adult) were 0.340, 0.224, 0.328 and 0.436 mg/L, respectively. The transcription patterns of 45 genes involved in hypothalamic-pituitary-thyroid/gonadal (HPT/HPG) axis, oxidative stress and apoptosis revealed KM could affect zebrafish larval development at multiple pathways...
December 8, 2018: Chemosphere
Jian Wang, Qing-Jun Zhang, Timothy J Pirolli, Zhi-Ping Liu, LaShondra Powell, Edward B Thorp, Michael Jessen, Joseph M Forbess
BACKGROUND: The pedicled greater omentum has been shown to offer benefit in ischemic heart disease for both animal models and human patients. The impact of cardio-omentopexy in a pressure overload model of left ventricular hypertrophy (LVH) is unknown. METHODS: LVH was created in rats by banding the ascending aorta after right thoracotomy (n=23). Sham surgery was performed in 12 additional rats. Six weeks post-banding, surviving LVH rats were assigned to cardio-omentopexy via left thoracotomy (LVH+Om, n=8) or sham left thoracotomy (LVH, n=8)...
December 12, 2018: Annals of Thoracic Surgery
Ping Hu, Huairong Yang, Bo Lv, Daoyuan Zhao, Jing Wang, Weiyun Zhu
The objective of the present study was to explore the changes in fatty acids (FAs) and minerals composition in sow milk in order to improve the knowledge about FAs and mineral requirements for piglets. The FAs and minerals composition in the sow milk samples which were collected from ten sows during a period of 16 days of lactation was analysed. The proportion of FAs in sow milk has a significant increase in C8:0, C10:0, C12:0, C14:0, C16:0, C14:1 and C16:1 FAs and the sum of saturated fatty acids (SFAs) according to the lactation period (p < 0...
December 14, 2018: Journal of Animal Physiology and Animal Nutrition
Yun Liu, Yue Chang, Shuxiong Lu, Yuan-Yuan Xiang
Accumulating research works have reported that long noncoding RNAs (lncRNAs) are involved in various cancers, including cervical cancer. LncRNA DGCR5 has been identified in many cancers. However, the biological role of DGCR5 in cervical cancer remains barely known. We aimed to investigate the biological function of DGCR5 in cervical cancer progression. Here, in our current study, we observed that DGCR5 was downregulated in human cervical cancer cell lines (MS751, SiHa, HeLa, and HT-3) compared with the primary normal cervical squamous cells (NCSC1 and NCSC2)...
December 14, 2018: Journal of Cellular Physiology
Manuel Ignacio Monge Garcia, Zhongping Jian, Jos J Settels, Feras Hatib, Maurizio Cecconi, Michael R Pinsky
To compare the effective arterial elastance (Ea) obtained from the arterial pressure with Ea calculated from left-ventricular (LV) pressure-volume analysis. Experimental study. LV pressure-volume data was obtained with a conductance catheter and arterial pressures were measured via a fluid-filled catheter placed in the proximal aorta, femoral and radial arteries. Ea was calculated as LV end-systolic pressure (ESP)/stroke volume (SV). Experimental protocol consisted sequentially changing afterload (phenylephrine/nitroprusside), preload (bleeding/fluid), and contractility (esmolol/dobutamine)...
December 14, 2018: Journal of Clinical Monitoring and Computing
Nicola Galea, Gian Marco Dacquino, Rosa Maria Ammendola, Simona Coco, Luciano Agati, Laura De Luca, Iacopo Carbone, Francesco Fedele, Carlo Catalano, Marco Francone
OBJECTIVES: To investigate the prognostic role of early post-infarction cardiac magnetic resonance (CMR) on long-term risk stratification of ST segment elevation myocardial infarction (STEMI) patients with preserved left ventricular ejection fraction (LVEF). METHODS: Seventy-seven STEMI patients treated by primary percutaneous coronary intervention (PCI) and LVEF > 50% at CMR were included. The median time between STEMI and CMR was 5 days (IQR 2-8). LV volumes and function, area at risk (on T2 weighted images), infarcted myocardium (on late enhanced images), intramyocardial hemorrhage, and early and late microvascular obstruction (MVO) were detected and measured...
December 14, 2018: European Radiology
Rossana Orabona, Edoardo Sciatti, Enrico Vizzardi, Federico Prefumo, Ivano Bonadei, Adriana Valcamonico, Marco Metra, Roberto Lorusso, Chahinda Ghossein-Doha, Marc E A Spaanderman, Tiziana Frusca
Excessive left ventricular (LV) mass (LVM) increase results in inefficient LV work with high energy waste and a negative prognostic effect. We aimed to investigate the presence of inappropriate LVM and to calculate the myocardial mechanoenergetic efficiency index (MEEi) in asymptomatic women with a history of early-onset (EO) or late-onset (LO) pre-eclampsia (PE). Among all women diagnosed with PE in the years 2009-2013, after applying inclusion/exclusion criteria and cost-effectiveness analysis, we randomly selected thirty women who experienced EO-PE, thirty with a previous LO-PE and thirty healthy controls to undergo echocardiography from 6 months to 4 years after delivery...
December 14, 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
J Podolec, J Baran, M Siedlinski, M Urbanczyk, M Krupinski, K Bartus, L Niewiara, M Podolec, T Guzik, L Tomkiewicz-Pajak, M Komar, A Kablak-Ziembicka
Regulated on Activation Normal T Expressed and Secreted (RANTES) chemokine is involved in the initiation of inflammation and immune-cell recruitment. Interleukin -6 (IL-6) is used as a general index of severity of the chronic inflammatory process. Finally, transforming growth factor-β (TGF-β) is an immune biomarker potentially involved in the regulation of valve fibrosis and calcification. The aim of this study was to analyze selected biomarkers associated with the different stages of immune-pathogenesis in aortic stenosis...
August 2018: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
Mengxia Chen, Qing Zhang, Chengwei Zhang, Xiaozhi Zhao, Giancarlo Marra, Jie Gao, Xiaoyu Lv, Bing Zhang, Yao Fu, Feng Wang, Xuefeng Qiu, Hongqian Guo
Purpose: To explore whether 68 Ga-PSMA PET/CT (PET/CT) or the combination of mpMRI and 68 Ga-PSMA PET/CT (com-MRI/PET) can improve the detection of csPCa. Methods: We retrospectively enrolled 54 patients who underwent both mpMRI and PET/CT before radical prostatectomy. Regions of interest (ROI) on imaging from mpMRI, PET/CT and pathology were marked. A lesion was defined when ROI was marked in the same location on continuous imaging at any of the imaging setting. All lesions were recorded by Prostate Imaging Reporting and Data System (PI-RADS), miPSMA expression score (MI-ES) and pathology results and analyzed...
December 14, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
Zuo-Lin Li, Lin-Li Lv, Tao-Tao Tang, Bin Wang, Ye Feng, Le-Ting Zhou, Jing-Yuan Cao, Ri-Ning Tang, Min Wu, Hong Liu, Steven D Crowley, Bi-Cheng Liu
Hypoxia promotes tubulointerstitial inflammation in the kidney. Although hypoxia inducible factor-1α (HIF-1α) is a master regulator of the response to hypoxia, the exact mechanisms through which HIF-1α modulates the induction of tubulointerstitial inflammation are still largely unclear. We demonstrated tubulointerstitial inflammation and increased tubular HIF-1α expression in murine models of ischemia/reperfusion injury and unilateral ureteral obstruction. Increased expression of HIF-1α in tubular epithelial cells was associated with selective shedding of microRNA-23a (miRNA-23a)-enriched exosomes in vivo and systemic inhibition of miRNA-23a prior to ischemia/reperfusion injury attenuated tubulointerstitial inflammation...
December 7, 2018: Kidney International
Weifeng Sun, Junyuan Lv, Liren Duan, Ruoran Lin, Yugang Li, Shanqiong Li, Chen Fu, Lin Zhao, Shijie Xin
Vascular remodeling is mainly caused by excessive proliferation of vascular smooth muscle cells (VSMCs). Noncoding RNAs (ncRNAs) have emerged as important regulators in diverse pathological processes. Previous work has shown the functions and mechanisms of long noncoding RNA H19 (LncRNA H19) on VSMCs. As long noncoding RNAs (lncRNAs) are complex in their mechanisms of action, the aim of the study is to identify if there are any other molecular mechanisms of LncRNA H19 on VSMCs. In vivo studies demonstrated that cyclin D1 was overexpressed in neointima of balloon-injured artery...
December 11, 2018: Biochemical and Biophysical Research Communications
Hassan Alkhawam, Rahil Rafeedheen, Elsayed Abo-Salem
Right ventricular (RV) dysfunction following surgical implantation of a left ventricular assist device (LVAD) is a well-documented phenomenon, and it is associated with poor outcomes. We are reporting a 25-year-old male patient who presented to the hospital with flu-like symptoms, hypotension and acute hypoxic respiratory failure. The patient's Laboratory data was significant for elevated troponin, and his Chest X-ray showed acute pulmonary edema. Echocardiogram revealed reduced left ventricular (LV) ejection fraction and normal RV function...
December 11, 2018: Heart & Lung: the Journal of Critical Care
Fei Kong, Juan Jin, Xiaolin Lv, Yubo Han, Xue Liang, Yanyu Gao, Xinglin Duan
OBJECTIVE: Coronary heart disease is a common cause of death and disability worldwide and mainly results from myocardial ischemia-reperfusion (I/R) injury. This study aimed to elucidate the roles and possible mechanism of long noncoding RNA Component Of Mitochondrial RNA Processing Endoribonuclease (RMRP) in protecting against ischemic myocardial injury. MATERIAL AND METHODS: The H9c2 cardiomyocytes were cultured under hypoxia condition to induce myocardial injury...
January 2019: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Yudong Xie, Yanping Lv, Yanli Zhang, Zhenzhen Liang, Lili Han, Yiyang Xie
LATS2 is a classical tumor suppressor that affects non-small cell lung cancer proliferation and mobilization. However, its role in lung cancer cell apoptosis is unknown. The aim of our study is to explore whether LATS2 activates mitochondria-related apoptosis in lung cancer cells. In the present study, A549 non-small cell lung cancer cells were transfected with a LATS2 adenovirus to induce LATS2 overexpression. Cell apoptosis was evaluated via the MTT assay, TUNEL staining, western blotting, trypan blue staining and ELISA...
January 2019: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Zhenzhang Chen, Xiao Hu, Yuan Wu, Li Cong, Xia He, Jianwei Lu, Jifeng Feng, Delin Liu
OBJECTIVE: Esophageal cancer is one of the deadliest cancers worldwide occurring at upper gastrointestinal tract. This study aimed to explore the possible role of long non-coding RNA X Inactive Specific Transcript (XIST) in the development of esophageal cancer. MATERIAL AND METHODS: The lncRNA XIST expressions both in esophageal cancer tissues and in cells were investigated. The TE-1 and SKGT-4 cells were transfected with LV-sh-XIST and LV-scramble for the further detection of the effects of XIST expression on cell biological processes, including proliferation, apoptosis and the expression of apoptosis-related proteins, migration, invasion and the expression of epithelial-mesenchymal transition markers...
January 2019: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Lin Shi, Yi Wu, Dian Liang Lv, Lei Feng
OBJECTIVES: Scutellarein is a flavonoid monomer found in traditional Chinese medicine such as Scutellaria barbata. This study aimed to investigate the cytotoxic effect of scutellarein treatment on multiple myeloma (MM) cells. METHODS: circulating B lymphocytes (CBL) isolated from healthy donors' peripheral blood served as control for MM.1R and IM-9 MM cells. CLB and MM cells were treated with various concentrations of scutellarein before their cell viability and apoptosis being evaluated...
January 2019: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Xiaolei Yang, Jie Gu, Haichen Lv, Huihua Li, Yunpeng Cheng, Yang Liu, Yinong Jiang
Hyperuricemia is an important risk factor for vascular inflammation, yet the potential mechanisms of uric acid (UA) in endothelial cells are not well understood. UA has been found to stimulate renin-angiotensin system (RAS) activation in human umbilical vein endothelial cells (HUVECs). (Pro)renin receptor ((P)RR) is widely expressed in endothelial cells and able to induce RAS activation. Whether UA-induced endothelial cell inflammation is via up-regulating (P)RR remained unknown. Primary HUVECs were cultured and treated with UA, under the condition of (P)RR or AT1 silencing...
January 2019: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Ling Zhu, Lihong Tong, Nan Zhao, Jie Li, Yizhong Lv
Based on the interaction between mesoscopic biochar materials and nanomaterials, the synergistic mechanism of the two materials in the process of cadmium remediation was studied. K2 CO3 activated porous biochar (KBC) loaded with nano-zero-valent iron (nZVI)/nano-α-hydroxy-iron oxide (nHIO) was studied. Macroscopically, batch adsorption experiments were carried out to describe the adsorption properties of the composites. Microscopically, the changes of surface chemical states were characterized by electron microscopy, XRD, FTIR and XPS...
December 7, 2018: Chemosphere
Xiang Liu, Lingtong Zhou, Peng Heng, Jingcheng Xiao, Junping Lv, Qingmiao Zhang, Michael E Hickey, Qin Tu, Jinyi Wang
The development of hepatocyte cultures in vitro holds great significance in the study of bioartificial liver support systems. Electrospun fiber cultures have received widespread attention as an effective method to culture hepatocytes in vitro. Polylactic acid (PLA) -a synthetic polymer with high biocompatibility and biodegradability- is widely used to fabricate electrospun fibers in the biomedical field. However, the use of PLA is limited in cell cultures due to its brittleness, strong hydrophobicity, and lack of biologically active functional groups...
September 28, 2018: Colloids and Surfaces. B, Biointerfaces
Neil T Srinivasan, Michele Orini, Rui Providencia, Ron Simon, Martin Lowe, Oliver R Segal, Anthony W Chow, Richard J Schilling, Ross J Hunter, Peter Taggart, Pier D Lambiase
BACKGROUND: The relationship between the surface ECG T-wave to intracardiac repolarization is poorly understood. OBJECTIVES: This study aimed to examine the association between intracardiac ventricular repolarization and the T-wave on the body surface ECG (SECGTW ). METHODS: 10 normal heart patients (age 35 +/- 15yrs, 6Male), were studied. Decapolar EP catheters were placed in the right ventricle (RV) and lateral left ventricle (LV) to record in an apico-basal orientation and lateral LV branch of the coronary sinus (CS) for transmural (TM) recording...
December 11, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
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