Luna Zhai, Wangling Hu, Jingyong Li, Dan Li, Ni Xia, Tingting Tang, Shaofang Nie, Min Zhang, Jiao Jiao, Bingjie Lv, Fen Yang, Yuzhi Lu, Lingfeng Zha, Muyang Gu, Xiajun Hu, Shuang Wen, Desheng Hu, Li Zhang, Weimin Wang, Xiang Cheng
Immune cell infiltration is a significant pathological process in abdominal aortic aneurysms (AAA). T cells, particularly CD4+ T cells, are essential immune cells responsible for substantial infiltration of the aorta. Regulatory T cells (Tregs) in AAA have been identified as tissue-specific; however, the time, location, and mechanism of acquiring the tissue-specific phenotype are still unknown. Using single-cell RNA sequencing (scRNA-seq) on CD4+ T cells from the AAA aorta and spleen, we discovered heterogeneity among CD4+ T cells and identified activated, proliferating and developed aorta Tregs...
April 18, 2024: Immunology