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Xiaoyan Zhang, Zhan-Qiu Liu, Dara Singh, David K Powell, Charles S Chung, Kenneth S Campbell, Jonathan F Wenk
The present study assessed the acute effects of isoproterenol on left ventricular (LV) mechanics in healthy rats with the hypothesis that ß-adrenergic stimulation influences the mechanics of different myocardial regions of the LV wall in different ways. To accomplish this, magnetic resonance images were obtained in the LV of healthy rats with or without isoproterenol infusion. The LV contours were divided into basal, mid-ventricular, and apical regions. Additionally, the mid-ventricular myocardium was divided into three transmural layers with each layer partitioned into four segments (i...
August 4, 2018: Journal of Biomechanical Engineering
Xiaoye Li, Zi Wang, Qibing Wang, Qing Xu, Qianzhou Lv
Acute coronary syndrome (ACS) has become a vital disease with high mortality worldwide. A combined anti-platelet therapy (aspirin and a P2Y12 antagonist) is commonly used to prevent re-infarction in ACS patients who have undergone percutaneous coronary intervention (PCI). Clopidogrel, a P2Y12 antagonist, plays an important role in the inhibition of platelet aggregation (IPA). However, it is a pro-drug requiring bio-transformation by cytochrome P450 (CYP450). The aim of this study is to unravel the effect of clopidogrel-associated genetic variants on inhibition of platelet activity and clinical outcomes in ACS patients...
August 11, 2018: Basic & Clinical Pharmacology & Toxicology
K-A Dawn Lim, Hwei Wuen Chan, Ce Zheng, Maria C Aquino, Robert Ritch, Paul Tk Chew
IMPORTANCE: Argon laser peripheral iridoplasty (ALPI) could be effective in widening residual angle closure following laser peripheral iridotomy (LPI). BACKGROUND: We investigated changes in angle parameters following ALPI and its safety profile in this study. DESIGN: Retrospective, observational case series. PARTICIPANTS: The records from a single center, of 36 patients (60 eyes) who underwent ALPI, for residual angle closure following LPI, were reviewed...
August 11, 2018: Clinical & Experimental Ophthalmology
T Kotwica, J Relewicz, A Rojek, M Tupikowska-Marzec, M Kabaj, B Karolko, J Maj, G Bednarek-Tupikowska, W Kosmala, J C Szepietowski, M Przewlocka-Kosmala
BACKGROUND: Psoriasis has been shown to increase cardiovascular risk, and a contributor to this might be enhanced myocardial fibrosis promoted by the disease-associated proinflammatory milieu. OBJECTIVE: We sought to investigate the relationship of galectin-3 (Gal-3) - a recognized mediator of fibrosis with inflammatory activation and left ventricular (LV) systolic and diastolic function in patients with psoriasis. METHODS: We enrolled 102 psoriatic patients (mean age: 52...
August 11, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
Syed Yaseen Naqvi, Anas Jawaid, Ilan Goldenberg, Valentina Kutyifa
PURPOSE OF REVIEW: Cardiac resynchronization therapy (CRT) is an effective treatment option for therapy-refractory mild to severe heart failure (HF) patients with reduced ejection fraction and left ventricular (LV) conduction delay. Multiple clinical trials have shown that CRT improves cardiac function and overall quality of life, as well as reduces HF hospitalizations, health care costs, and mortality. RECENT FINDINGS: Despite its effectiveness, the "non-response" rate to CRT is around 30%, remaining a major challenge that faces electrophysiologists and researchers...
August 10, 2018: Current Heart Failure Reports
Liqiong Lv, Huawei Lv, Xujun Qiu, Jizhong Yan, Shengqiang Tong
Racemic trans-paroxol, trans-N-methylparoxetine and trans-paroxetine containing two chiral centres were stereoselectively separated using countercurrent chromatography with hydroxypropyl-β-cyclodextrin as the chiral selector. A two-phase solvent system composed of n-butyl acetate and 0.1 mol L-1 sodium carbonate-sodium bicarbonate buffer at pH 9.2 (1:1, v/v) was selected, and 0.10 mol L-1 hydroxypropyl-β-cyclodextrin was added to the aqueous phase as the chiral selector. Racemic trans-N-methylparoxetine and racemic trans-paroxol (20 mg of each) were stereoselectively separated by countercurrent chromatography in an individual run, yielding 7...
July 27, 2018: Journal of Chromatography. A
Eleonora Avenatti, Stephen H Little, Colin M Barker, Sherif F Nagueh
Left atrial (LA) reverse remodeling occurs after transcatheter mitral valve repair, but additional data are needed about changes in LA function. Changes in LA stiffness in patients undergoing MitraClip implantation were evaluated. Baseline, procedural, and 30-day follow-up clinical and imaging data of patients undergoing MitraClip were reviewed. LA operating chamber stiffness was calculated as the ratio of systolic change in LA pressure to LA systolic strain and to stroke volume. Matched preprocedure and postprocedure LA strain analyses were performed in 35 patients, 21 with primary and 14 with functional mitral regurgitation (MR)...
July 5, 2018: American Journal of Cardiology
Jianzhong Su, Yung-Hsin Huang, Xiaodong Cui, Xinyu Wang, Xiaotian Zhang, Yong Lei, Jianfeng Xu, Xueqiu Lin, Kaifu Chen, Jie Lv, Margaret A Goodell, Wei Li
BACKGROUND: Cancers have long been recognized to be not only genetically but also epigenetically distinct from their tissues of origin. Although genetic alterations underlying oncogene upregulation have been well studied, to what extent epigenetic mechanisms, such as DNA methylation, can also induce oncogene expression remains unknown. RESULTS: Here, through pan-cancer analysis of 4174 genome-wide profiles, including whole-genome bisulfite sequencing data from 30 normal tissues and 35 solid tumors, we discover a strong correlation between gene-body hypermethylation of DNA methylation canyons, defined as broad under-methylated regions, and overexpression of approximately 43% of homeobox genes, many of which are also oncogenes...
August 10, 2018: Genome Biology
Vicente Mora, Ildefonso Roldán, Elena Romero, Assumpció Saurí, Diana Romero, Jana Pérez-Gozalbo, Natalia Ugalde, Javier Bertolín, Melisa Rodriguez-Israel, Carmen Pérez-Olivares Delgado, Jorge A Lowenstein
BACKGROUND: According to the ventricular myocardial band model, the diastolic isovolumetric period is a contraction phenomenon. Our objective was to employ speckle-tracking echocardiography (STE) to analyze myocardial deformation of the left ventricle (LV) and to confirm if it supports the myocardial band model. METHODS: This was a prospective observational study in which 90 healthy volunteers were recruited. We evaluated different types of postsystolic shortening (PSS) from an LV longitudinal strain study...
August 9, 2018: Journal of Cardiovascular Development and Disease
Mingwei Zhao, Wenjiao Lv, Yuyang Li, Caili Dai, Hongda Zhou, Xuguang Song, Yining Wu
Nanofluids have increasingly drawn interest in recent years with their various applications in a number of fields. The method for the preparation of stable nanofluids is a key concern for extending the application of nanofluids. This study focuses on the effect of pH, dosage of surfactant (TX-100), and nanofluid concentration on the stability of a silica nanofluid. Particle size and zeta potential are two important factors to consider in evaluating the stability of the silica nanofluid. Results indicate that the stability of the silica nanofluid highly depends on pH, dosage of surfactant (TX-100), and nanofluid concentration...
August 8, 2018: Materials
Nataliia V Shults, Oleksiy Melnyk, Dante I Suzuki, Yuichiro J Suzuki
Right-sided heart failure is the major cause of death among patients who suffer from various forms of pulmonary hypertension and congenital heart disease. The right ventricle (RV) and left ventricle (LV) originate from different progenitor cells and function against very different blood pressures. However, differences between the RV and LV formed after birth have not been well defined. Work from our laboratory and others has accumulated evidence that redox signaling, oxidative stress and antioxidant regulation are important components that define the RV/LV differences...
August 8, 2018: Antioxidants (Basel, Switzerland)
Cuicui Lv, Bolong Liang, Kexun Li, Yong Zhao, Hongwen Sun
The slow oxygen reduction reaction (ORR) hampers the efficiency of microbial fuel cells (MFCs) to a large extent, which usually requires catalysts to facilitate the electron transfer. The major challenge of the existed non-precious metals in place of the noble metal catalysts (Pt, Pd, Au et al.) for ORR is their low efficiency, which urgently needs special route to tackle this issue. Herein, we report a simple and convenient technique using prussian blue analogues as precursor to directly synthesize the N-doped graphene encapsulated CoFe alloy which is present in "Core-Shell" structure via calcination of Co2 Fe(CN)6 in inert condition...
October 15, 2018: Biosensors & Bioelectronics
Manuel Ignacio Monge García, Arnoldo Santos, Beatriz Diez Del Corral, Pedro Guijo González, Manuel Gracia Romero, Anselmo Gil Cano, Maurizio Cecconi
PURPOSE: To determine whether noradrenaline alters the arterial pressure reflection phenomena in septic shock patients and the effects on left ventricular (LV) efficiency. MATERIAL AND METHODS: Thirty-seven septic shock patients with a planned change in noradrenaline dose. Timing and magnitude (Reflection Magnitude and Augmentation Index) of arterial reflections were evaluated. Total, steady, and oscillatory LV power (also expressed as fraction of the total power), subendocardial viability ratio (SEVR), energy efficiency and transmission ratios were used as a marker of LV efficiency...
July 29, 2018: Journal of Critical Care
Shih-Lin Chang, Ya-Wen Hsiao, Yung-Nan Tsai, Shien-Fong Lin, Shuen-Hsin Liu, Yenn-Jiang Lin, Li-Wei Lo, Fa-Po Chung, Tze-Fan Chao, Yu-Feng Hu, Ta-Chuan Tuan, Jo-Nan Liao, Yu-Cheng Hsieh, Tsu-Juey Wu, Satoshi Higa, Shih-Ann Chen
BACKGROUND: We aimed to investigate the impact of interleukin (IL)-17 on ventricular remodeling and the genesis of ventricular arrhythmia (VA) in an ischemic heart failure (HF) model. The expression of the proinflammatory cytokine IL-17 is upregulated during myocardial ischemia and plays a fundamental role in postinfarct inflammation. However, the influence of IL-17 on the genesis of VA has not yet been studied. METHODS AND RESULTS: The level of inflammation and Th17 cell (CD4+ IL-17+ ) expression in the rabbit model of ischemic HF were studied by flow cytometry, quantitative polymerase chain reaction (qPCR), and enzyme-linked immunosorbent assay (ELISA)...
August 7, 2018: Journal of Molecular and Cellular Cardiology
Yanbo Teng, Yanjun Ding, Mingming Zhang, Xinren Chen, Xizi Wang, Hang Yu, Chonghui Liu, Hongchao Lv, Ruijie Zhang
Lung cancer is the leading cause of cancer-related death worldwide. Most lung cancer is non-small cell lung cancer (NSCLC), in which malignant cells form in the lung epithelium. Mutations in multiple genes and environmental factors both contribute to NSCLC, and although some NSCLC susceptibility genes have been characterized, the pathogenesis of this disease remains unclear. To identify genes conferring NSCLC risk and determine their associated pathological mechanism, we combined genome-wide haplotype associated analysis with gene prioritization using 224,677 SNPs in 37 NSCLC cell lines and 116 unrelated European individuals...
August 7, 2018: Journal of Theoretical Biology
Wenfeng Du, Honggang Cheng, Lipan Peng, Daogui Yang, Chenggang Yang
Our study desired to investigate how miR-34c-3p regulates colon cancer cell proliferation and what is the relationship between miR-34c-3p and EIF3D. HCEpiC (normal human colonic epithelial cells), SW620, HT-29, SW480, and HCT-116 (human colon cancer cells lines) were used in our study. SW620 cells were chosen and divided into blank, miR-34c-3p mimics, miR-34c-3p NC, miR-34c-3p inhibitors, Lv-EIF3D, Lv-NC, and miR-34c-3p mimics+Lv-EIF3D groups. qRT-PCR was used for the detection of miR-34c-3p and EIF3D mRNA expressions...
August 9, 2018: Anti-cancer Drugs
Xiu-He Lv, Bo-Ling Wang, Guo-Wu Cao
BACKGROUND: The role of narrow band imaging (NBI) for surveillance colonoscopy in patients with inflammatory bowel disease (IBD) is debatable. We aim to compare NBI versus other endoscopic techniques in surveillance of IBD basing on current evidences. METHODS: A systematic search of PubMed, Embase, and the Cochrane Library databases was conducted for relevant studies. To assess the detection efficacy, we estimated risk ratios (RRs) for dichotomous outcomes and mean differences (MDs) for continuous outcomes...
August 9, 2018: Journal of Clinical Gastroenterology
Fang Yao, Yihong Fan, Bin Lv, Conghua Ji, Li Xu
The aim of this study was to examine the expression of serological markers in patients with inflammatory bowel disease in China, and determine the diagnostic utility of serological markers, individually and in combination, for the diagnosis and differential diagnosis of Crohn's disease (CD).Serum samples were obtained from 160 participants in Eastern China. Among the participants, 98 were diagnosed with CD, 33 had ulcerative colitis (UC), and 29 were healthy controls (HC). The serum samples were tested for the presence of antibodies against outer membrane porin C (anti-OmpC), Pseudomonas fluorescens bacterial sequence I2 (anti-I2), anti-laminarin (anti-L), anti-chitin (anti-C), anti-chitobioside carbohydrate antibody (ACCA), anti-laminaribioside carbohydrate antibody (ALCA), anti-mannobioside carbohydrate antibody (AMCA), and anti-Saccharomyces cerevisiae antibody (ASCA) by indirect enzyme-linked immunosorbent assay (ELISA)...
August 2018: Medicine (Baltimore)
Lingzhi Ni, Keke Li, Longfei Jiang, Jie Chen, Yanyan Chen, Xiaoman Li, Na Lin, Frank Thorn, Ruzhi Deng
PURPOSE: The purposes of the study were to analyze patient use and satisfaction with low vision aids (LVAs) at the Wenzhou Medical University Low Vision and Rehabilitation Center and to assess the promotion of visual rehabilitation services as a new responsibility for nurses in China. METHODS: Records of 178 patients with low vision (LV) from the Low Vision and Rehabilitation Center examined between October 2015 and October 2016 included basic patient information (e...
August 8, 2018: Rehabilitation Nursing: the Official Journal of the Association of Rehabilitation Nurses
You-Cai Zhu, Wen-Xian Wang, Chun-Wei Xu, Wu Zhuang, Zheng-Bo Song, Kai-Qi Du, Gang Chen, Tang-Feng Lv, Yong Song
In non-small cell lung cancer (NSCLC), driver gene alterations, such as EGFR, ALK, MET, and ROS1, are usually mutually exclusive. Few clinical cases with co-existing ROS1 fusion and de-novo MET amplification have been reported. In addition, the efficacy of crizotinib in Chinese patients with driver co-existing alterations is uncertain. A 65-year-old female was diagnosed with lung adenocarcinoma metastatic to the brain. She had sufficient tumor tissue for detection of the target gene; however, common driver gene mutations, such as EGFR-wild and ALK-negative, were not initially detected...
August 10, 2018: Cancer Biology & Therapy
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