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Amneet Sandhu, Joseph L Schuller, Wendy S Tzou, Alexis Z Tumolo, William H Sauer, Duy T Nguyen
A 62-year-old man was referred to our institution for high-density, symptomatic PVCs with resultant decrease in LV function having failed prior ablation attempts. Successful, durable ablation of the patient's mid-myocardial PVC arising from the LV summit region was achieved through the proximal great cardiac vein with ablation depth augmented by use of half-normal saline irrigant. Though standard ablation of ventricular arrhythmias using normal saline irrigation from the coronary venous system has been well-reported, this may be of limited value in addressing mid-myocardial sites of origin...
October 20, 2018: Pacing and Clinical Electrophysiology: PACE
Navin K Kapur, Colin S Hirst
Limited data exploring the utility of IABPs in shock without acute myocardial infarction exist. Counterpulsation pumps depend on native LV contractile function. Hemodynamic monitoring with a pulmonary artery catheter should help guide management of the cardiogenic shock patient. More studies are required to identify the optimal patient population and hemodynamic parameters best suited for IABP therapy.
October 1, 2018: Catheterization and Cardiovascular Interventions
Hui-Deng Long, Yu-Shui Ma, Hui-Qiong Yang, Shao-Bo Xue, Ji-Bin Liu, Fei Yu, Zhong-Wei Lv, Ji-Yu Li, Ru-Ting Xie, Zheng-Yan Chang, Gai-Xia Lu, Wen-Ting Xie, Da Fu, Li-Juan Pang
Hsa-MicroRNA-124a-3p (hsa-miR-124-3p) is involved in tumor progression in certain malignant tumors. However, its function and clinical implication in hepatocellular carcinoma (HCC) have not yet been illustrated. In this study, we explored the expression and prognostic value of hsa-miR-124-3p in patients with HCC. Hsa-miR-124-3p expression in HCC was analyzed in silico, which was subsequently confirmed by quantitative PCR in 155 HCC biopsy samples. Overall survival (OS) and disease-free survival in HCC patients was evaluated by Kaplan-Meier survival analysis, and univariate and multivariate Cox proportional hazard models were used...
October 19, 2018: Molecular Biology Reports
Philip Brainin, Sofie Reumert Biering-Sørensen, Rasmus Møgelvang, Martina Chantal de Knegt, Flemming Javier Olsen, Søren Galatius, Gunnar Hilmar Gislason, Jan Skov Jensen, Tor Biering-Sørensen
Post-systolic shortening (PSS) does not contribute to the ejection of blood and may inhibit diastolic filling. We determined normal values of PSS in healthy subjects and investigated associations with echocardiographic and invasive measures of systolic and diastolic function. We prospectively analyzed participants from the general population (n = 620, mean age 47 ± 14 years) with no cardiovascular disease. Participants underwent echocardiography, including speckle tracking assessment of the post-systolic index (PSI), strain and time...
October 19, 2018: International Journal of Cardiovascular Imaging
Sascha Ketelhut, Ingomar W Franz, Reinhard G Ketelhut
INTRODUCTION: Left ventricular hypertrophy (LVH) can be successfully reduced by antihypertensive medication. Both hypertension and aerobic exercise can cause increases in left ventricular mass (LV-mass). AIM: Therefore, hypertensive athletes with LVH were studied to investigate the effect of antihypertensive medication on LV-mass reduction despite continuing their regular intensive exercise programs. METHODS: 14 previously untreated hypertensive male athletes (A) with LVH and a prolonged history of endurance training where included in the study...
October 20, 2018: High Blood Pressure & Cardiovascular Prevention: the Official Journal of the Italian Society of Hypertension
Meng-Jie Zhao, Si-Yuan Chen, Xiao-Ying Qu, Bilal Abdul-Fattah, Ting Lai, Meng Xie, Shi-di Wu, You-Wen Zhou, Chang-Zheng Huang
Keloid may induce severe impairment of life quality for the patients, although keloid is a cutaneous benign tumor. Collagen triple helix repeat containing protein 1 (Cthrc1) was identified as a novel gene that was originally found in adventitial fibroblasts after arterial injury. To address the role of Cthrc1 in keloid, the expression level of Cthrc1 was assessed in normal skin and keloid tissue, as well as in normal fibroblasts (NFs) and keloid fibroblasts (KFs) by using quantitative PCR, Western blotting and immunohistochemical analysis...
October 2018: Current medical science
Ji Wu, Xien Liu, Xiao Zhang, Zhiyang He, Ping Lv
Mastering of medical knowledge to human is a lengthy process that typically involves several years of school study and residency training. Recently, deep learning algorithms have shown potential in solving medical problems. Here we demonstrate mastering clinical medical knowledge at certificated-doctor-level via a deep learning framework Med3R, which utilizes a human-like learning and reasoning process. Med3R becomes the first AI system that has successfully passed the written test of National Medical Licensing Examination in China 2017 with 456 scores, surpassing 96...
October 19, 2018: Nature Communications
Hannah A Cooper, Satoru Eguchi
Ischemia reperfusion (I/R) injury is a common event following myocardial infarction (MI) resulting in excessive oxidative stress, calcium overload, inflammation, and cardiomyocyte death. Mitochondrial homeostasis including their dynamics are imbalanced in cardiac I/R injury in favor of increased mitochondrial fission. Inhibition of mitochondrial fission prior to I/R injury is protective and improves cardiac function following MI. Clinically, patients with MI often receive treatment following initiation of the ischemic event...
October 31, 2018: Clinical Science (1979-)
Na Luo, Jing Sui, Jiayu Chen, Fuquan Zhang, Lin Tian, Dongdong Lin, Ming Song, Vince D Calhoun, Yue Cui, Victor M Vergara, Fanfan Zheng, Jingyu Liu, Zhenyi Yang, Nianming Zuo, Lingzhong Fan, Kaibin Xu, Shengfeng Liu, Jian Li, Yong Xu, Sha Liu, Luxian Lv, Jun Chen, Yunchun Chen, Hua Guo, Peng Li, Lin Lu, Ping Wan, Huaning Wang, Huiling Wang, Hao Yan, Jun Yan, Yongfeng Yang, Hongxing Zhang, Dai Zhang, Tianzi Jiang
BACKGROUND: In the past decades, substantial effort has been made to explore the genetic influence on brain structural/functional abnormalities in schizophrenia, as well as cognitive impairments. In this work, we aimed to extend previous studies to explore the internal mediation pathway among genetic factor, brain features and cognitive scores in a large Chinese dataset. METHODS: Gray matter (GM) volume, fractional amplitude of low-frequency fluctuations (fALFF), and 4522 schizophrenia-susceptible single nucleotide polymorphisms (SNP) from 905 Chinese subjects were jointly analyzed, to investigate the multimodal association...
October 16, 2018: EBioMedicine
Kunhao Yang, Zhongqiu Li, Yueguang Lv, Chuyi Yu, Peilong Wang, Xiaoou Su, Li Wu, Yujian He
An electrochemical aptasensor for ultrasensitive detection of hydroxylated polychlorinated biphenyl (OH-PCB) was developed. In this work, the sulfydryl aptamer selected for OH-PCB was easily immobilized on the surface of the modified glassy carbon electrode via Au-S bond due to incorporation of gold nanoparticles/poly dimethyl diallyl ammonium chloride-graphene composite. The fabrication process of the electrochemical aptasensor was characterized by electrochemical impedance spectroscopy and cyclic voltammetry...
December 24, 2018: Analytica Chimica Acta
Wen-Tong Liu, Yu-Jin Lv, Rui-Cheng Yang, Ji-Yang Fu, Lu Liu, Huan Wang, Qi Cao, Chen Tan, Huan-Chun Chen, Xiang-Ru Wang
BACKGROUND: Bacterial meningitis remains a big threat to the integrity of the central nervous system (CNS), despite the advancements in antimicrobial reagents. Escherichia coli is a bacterial pathogen that can disrupt the CNS function, especially in neonates. E. coli meningitis occurs after bacteria invade the brain microvascular endothelial cells (BMECs) that form a direct and essential barrier restricting the entry of circulating microbes and toxins to the brain. Previous studies have reported on several cellular proteins that function during meningitic E...
October 19, 2018: Journal of Neuroinflammation
Pengjun Wang, Tengbo Yu, Qiulan Lv, Shaoke Li, Xuexiao Ma, Guanpin Yang, Daxing Xu, Xiu Liu, Guangtao Wang, Zeqing Chen, Shi-Chao Xing
Cell adhesion was the first step of bone reconstruction. While hydroxyapatite (HA)/graphene composites had been utilized for improving the cell adhesion and bone osteogenesis, the impact of cell adhesion and HA/graphene composites, especially HA/hydrophilic graphene (HG) composites, on internal interaction force and external surface properties remained poorly understood. Here, higher stability HA/HG composites were synthesized without extra ion introduction with in situ self-assembling method. And with XRD, FT-IR, XPS and Raman analyses, the evidences of the formation of HA and the introduction of HG was clear...
October 10, 2018: Colloids and Surfaces. B, Biointerfaces
Xufei Li, Junzhi Sun, Yangli Che, Yan Lv, Fang Liu
In order to control bacterial pollution in water treatment, it is necessary to prepare efficient antibacterial materials. Novel chitosan chloride-graphene oxide (CSCl@GO) composites were prepared via a one-step solution blending method. The composites were characterized by FT-IR, XRD and TEM techniques. The antibacterial mechanism of CSCl@GO composites was investigated using gram-negative bacteria E. coli and gram-positive bacteria S. aureus as two model microorganisms. The antibacterial properties of CSCl@GO composites for complex bacteria in the cooling water system were researched...
October 16, 2018: International Journal of Biological Macromolecules
Xin Guo, Jing Wang, Jingjuan Pang, Yueying Lu, Shaobo Lv, Ning Wang, Jie Yuan
BACKGROUND: The aim of this study was to investigate the serum non-high-density lipoprotein cholesterol (non-HDLC) levels of first-episode, drug-naive depressive patients and the correlative factors. METHODS: The study group comprised 308 subjects including 150 drug-naive patients with first-episode depressive disorder and 158 control subjects diagnosed in the Affiliated Kailuan Mental Health Center, North China University of Science and Technology, Tangshan, Hebei, China, from June 2014 to November 2015...
October 19, 2018: Journal of Clinical Psychopharmacology
Rui Adão, Pedro Mendes-Ferreira, Carolina Maia-Rocha, Diana Santos-Ribeiro, Patrícia Gonçalves Rodrigues, André Vidal-Meireles, Cláudia Monteiro-Pinto, Luís D Pimentel, Inês Falcão-Pires, Gilles W De Keulenaer, Adelino F Leite-Moreira, Carmen Brás-Silva
We have previously shown that treatment with recombinant human neuregulin-1 (rhNRG-1) improves pulmonary arterial hypertension (PAH) in a monocrotaline (MCT)-induced animal model, by decreasing pulmonary arterial remodeling and endothelial dysfunction, as well as by restoring RV function. Additionally, rhNRG-1 treatment showed direct myocardial anti-remodelling effects in a model of pressure loading of the RV without PAH. This work aimed to study the intrinsic cardiac effects of rhNRG-1 on experimental PAH and RV pressure overload, and more specifically on diastolic stiffness, at both the ventricular and cardiomyocyte level...
October 19, 2018: Clinical and Experimental Pharmacology & Physiology
Y C Zhu, W X Wang, C W Xu, Q X Zhang, K Q Du, G Chen, T F Lv, Y Song
No abstract text is available yet for this article.
October 18, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
Muxin Lu, Yajuan Deng, Yi Luo, Junping Lv, Tianbao Li, Juan Xu, Shu-Wei Chen, Jinyi Wang
The development of an effective method for detecting heavy metal ions remains a serious task due to their high toxicity to public health and environments. Herein, a new electrochemical method based on a graphene aerogel (GA) and metal-organic framework (MOF) composites was developed for simultaneous detection of multiple heavy metal ions in aqueous solutions. The GA-MOF composites were synthesized via the in situ growth of the MOF UiO-66-NH2 crystal on the GA matrix. GA not only serves as the backbone for UiO-66-NH2 but also enhances the conductivity of the composites by accelerating the electron transfer in the matrix...
October 19, 2018: Analytical Chemistry
Shixiong Jiang, Dazhuang Miao, Muhong Wang, Jiachen Lv, Yihui Wang, Jinxue Tong
Colorectal cancer (CRC) remains both common and fatal, and its successful treatment is greatly limited by the development of stem cell-like characteristics (stemness) and chemoresistance. MiR-30-5p has been shown to function as a tumor suppressor by targeting the Wnt/β-catenin signaling pathway, but its activity in CRC has never been assessed. We hypothesized that miR-30-5p exerts anti-oncogenic effects in CRC by regulating the USP22/Wnt/β-catenin signaling axis. In the present study, we demonstrate that tissues from CRC patients and human CRC cell lines show significantly decreased miR-30-5p family expression...
October 19, 2018: Journal of Cellular and Molecular Medicine
J-H Jiang, Q-Y Lv, Y-X Yi, J Liao, X-W Wang, W Zhang
OBJECTIVE: We investigate whether microRNA-200a could regulate proliferation and invasion of ovarian cancer cells, thereby participating in the occurrence and development of ovarian cancer. We also explore the specific mechanism of microRNA-200a in regulating ovarian cancer. PATIENTS AND METHODS: Expression level of microRNA-200a in ovarian cancer tissues and paracancerous tissues were detected by quantitative Real-time polymerase chain reaction (qRT-PCR). The regulatory effects of microRNA-200a on proliferation and invasion of ovarian cancer cells were examined by Cell counting kit-8 (CCK-8) and cell invasion assay, respectively...
October 2018: European Review for Medical and Pharmacological Sciences
Michael P Gannon, Shahryar G Saba, Benjamin J Hirsh, Jonathan L Halperin, Mario J Garcia, Sean P Pinney, Martin E Goldman
A left ventricular (LV) false tendon is a frequently visualized structure in echocardiography with unclear clinical significance. We present the case of a false tendon serving as a nidus for thrombus in a post-orthotopic heart transplantation patient. Three-dimensional transthoracic echocardiography (3DTTE) was utilized to visualize a LV mass and facilitate its identification as a thrombus as well as the surrounding structures. Using datasets from 3DTTE, the lack of ventricular wall attachment and circumferential formation of the thrombus around the false tendon was identified...
October 18, 2018: Echocardiography
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