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My journals

Rexford S Ahima
This issue of the Journal of Clinical Investigation marks the transition of the position of editor from Gordon Tomaselli to me. It is with great humility that I begin my tenure as the editor of the flagship journal of the American Society for Clinical Investigation (ASCI). On behalf of the JCI editorial board and editorial staff, I wish Gordon Tomaselli all the best in his new position as the dean of the Albert Einstein College of Medicine.
July 2, 2018: Journal of Clinical Investigation
Rosanne Beuthin
Accessing medical assistance in dying (MAiD) became legal in Canada in June, 2016. This marks a unique time in our history, as eligible persons can now opt for an assisted death and health care professionals can be involved without criminal repercussion. I used an autoethnographic approach to explore and describe my experience of implementing and coordinating a new MAiD program in a local health authority. Part I is a self-reflexive narrative based on journal entries about my immersion in this practice role over a 6 month period...
September 2018: Qualitative Health Research
Caroline West
Supercritical fluid chromatography (SFC), which employs pressurized carbon dioxide as the major component of the mobile phase, has been known for several decades but has faced a significant resurgence of interest in the recent years, thanks to the development of modern instruments to comply with current expectations in terms of robustness and sensitivity. This review is focused on the recent literature, specifically since the introduction of modern systems but in relation to older literature, to identify the changing trends in application domains...
July 27, 2018: Analytical and Bioanalytical Chemistry
Nicole M Le Douarin, Elisabeth Dupin
The neural crest has been the main object of my investigations during my career in science, up to now. It is a fascinating topic for an embryologist because of its two unique characteristics: its large degree of multipotency and the fact that its development involves a phase during which its component cells migrate all over the embryo and settle in elected sites where they differentiate into a large variety of cell types. Thus, neural crest development raises several specific questions that are at the same time, of general interest: what are the mechanisms controlling the migratory behavior of the cells that detach from the neural plate borders? What are the migration routes taken by the neural crest cells and the environmental factors that make these cells stop in elected sites where they differentiate into a definite series of cell types? When I started to be interested in the neural crest, in the late 1960s, this embryonic structure was the subject of investigations of only a small number of developmental biologists...
July 23, 2018: Developmental Biology
Mohamed Omar
Dear Editor, I have read the article entitled "Papillary vs Nonpapillary Puncture in Percutaneous Nephrolithotomy: A Prospective Randomized Trial, that just was published in Journal of EndourologyVol. 31, No. S1. I want to congratulate the authors for this article, and respectfully submit these comments. In the article, it has been indicated that infundibular approach for PCNL to the posterior middle renal calyces is not associated with higher blood loss or transfusion rate in comparison to the respective approach to the fornix of the papilla ...
July 26, 2018: Journal of Endourology
Sten Orrenius
My research activity started with studies on drug metabolism in rat liver microsomes in the early 1960s. The CO-binding pigment (cytochrome P450) had been discovered a few years earlier and was subsequently found to be involved in steroid hydroxylation in adrenal cortex microsomes. Our early studies suggested that it also participated in the oxidative demethylation of drugs catalyzed by liver microsomes, and that prior treatment of the animals with phenobarbital caused increased levels of the hemoprotein in the liver, and similarly enhanced rates of drug metabolism...
July 25, 2018: Annual Review of Pharmacology and Toxicology
(no author information available yet)
Reports an error in "Procedural frames in negotiations: How offering my resources versus requesting yours impacts perception, behavior, and outcomes" by Roman Trötschel, David D. Loschelder, Benjamin P. Höhne and Johann M. Majer ( Journal of Personality and Social Psychology , 2015[Mar], Vol 108[3], 417-435). In the article "Procedural Frames in Negotiations: How Offering My Resources Versus Requesting Yours Impacts Perception, Behavior, and Outcomes" by Roman Trötschel, David D. Loschelder, Benjamin P...
August 2018: Journal of Personality and Social Psychology
Jelte M Wicherts
SummaryIn their response to my criticism of their recent article in Journal of Biosocial Science (te Nijenhuis et al., 2017), te Nijenhuis and van den Hoek (2018) raise four points none of which concerns my main point that the method of correlated vectors (MCV) applied to item-level data represents a flawed method. Here, I discuss te Nijenhuis and van den Hoek's four points. First, I argue that my previous application of MCV to item-level data showed that the method can yield nonsensical results. Second, I note that meta-analytic corrections for sampling error, imperfect measures, restriction of range and unreliability of the vectors are futile and cannot help fix the method...
July 17, 2018: Journal of Biosocial Science
Gaia T Koster, T Truc My Nguyen, Adrien E D Groot, Jonathan M Coutinho, Jan Bosch, Heleen M den Hertog, Marianne A A van Walderveen, Ale Algra, Marieke J H Wermer, Yvo B Roos, Nyika D Kruyt
INTRODUCTION: Time is the most crucial factor limiting efficacy of intravenous thrombolysis (IVT) and intra-arterial thrombectomy (IAT). The delay between alarming the Emergency Medical Services (EMS) dispatch office and IVT/IAT initiation, that is, the 'total system delay' (TSD), depends on logistics and team effort. A promising method to reduce TSD is real-time audio-visual feedback to caregivers involved. With 'A Reduction in Time with Electronic Monitoring in Stroke' (ARTEMIS), we aim to investigate the effect of real-time audio-visual feedback on actual TSD to IVT/IAT to caregivers...
June 27, 2018: BMJ Open
Sven Nyholm
In their article in this journal, Sabine Müller, Merlin Bittlinger, and Henrik Walter launch a sweeping attack against what they call the "personal identity debate" as it relates to patients treated with deep brain stimulation (DBS). In this critique offered by Müller et al., the personal identity debate is said to: (a) be metaphysical in a problematic way, (b) constitute a threat to patients, and (c) use "vague" and "contradictory" statements from patients and their families as direct evidence for metaphysical theories...
2018: Neuroethics
Denys Wheatley
My concern in this presentation is with the falling standard of papers, particularly primary research articles, in the scientific and medical literature. Few of our younger generation of scientists (and many older ones) have never had specific training in how to write a good paper, and yet this is the major product of all research effort that has been done, perhaps over a year or more. This is a situation that has to be corrected by all institutions, universities and similar bodies, who need to introduce into the curriculum a course (not just a token lecture) that deals with the complexity of writing a lucid paper that is succinct and written with style...
June 14, 2018: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
Alison Searle
The relationship between pain as a physical and emotional experience and the concept of suffering as an essential aspect of sanctification for faithful believers was a paradoxical and pressing theological and phenomenological issue for puritan and non-conformist communities in 17th-century England. Pain allows the paradox of non-conformists' valorisation and suppression of corporeality to be explored due to its simultaneous impact on the mind and body and its tendency to leak across boundaries separating an individual believer from other members of their family or faith community...
June 2018: Medical Humanities
Paul E Terry
Opioid addiction has been cast as a "disease of despair."1 I agree, but I wonder still: If tobacco and opioids were on a spectrum relative to the relief they provide from social, emotional, financial, and other sources of pain in the lives of the disenfranchised, could it be that they are indeed 2 sides of the same coin? For individuals in despair, pain relief is a complicit actor in what will become pleasure seeking and, for smokers, vice versa. Every year, almost as many people are dying by incidentally being near smokers as are dying by accidentally overdosing...
June 2018: American Journal of Health Promotion: AJHP
Michael H Bennett
This report is a product of the VA Evidence-based Synthesis Program. The purpose is to provide "timely and accurate syntheses of targeted healthcare topics …. to improve the health and healthcare of Veterans". The authors have made a comprehensive search and analysis of the literature and make recommendations to assist clinicians in dealing with veterans suffering from either traumatic brain injury (TBI) or post-traumatic stress disorder (PTSD). The report is timely and of great potential impact given the vigorous and lengthy debate among hyperbaric physicians and lay people determined to find an answer for the large numbers of veterans deeply affected with some combination of PTSD and post-concussion dysfunction...
June 30, 2018: Diving and Hyperbaric Medicine: the Journal of the South Pacific Underwater Medicine Society
Cindy Lee
This is a personal account of some of the people and factors that were important in my career in chemical oceanography. I also discuss two areas of oceanographic research and training that I think need more attention. The first is how the difficulty in getting appropriate samples hampers our ability to fully understand biogeochemical processes in the sea. I have worked on dissolved materials, suspended and sinking particles, and sediments in lakes, oceans, rivers, and aerosols. Sample collection problems affect all those areas, although to different degrees...
May 31, 2018: Annual Review of Marine Science
Mark G Siegel
There continues to be controversy over the timing of anterior cruciate ligament (ACL) surgery. Early or delayed intervention after ACL injury is a topic that has not been settled. The issue is whether ACL tears should have surgery performed in an expedient manner. Or is delay an option with no repercussions to the health of the knee? My associates in nonsurgical specialties wave the New England Journal of Medicine to support their view that surgery is not needed. I routinely espouse the literature confirming that delay of surgery may cause future damage...
June 2018: Arthroscopy: the Journal of Arthroscopic & related Surgery
Alex Broadbent
This article is a reply to two critics of my "Prediction, Understanding, and Medicine," published elsewhere in this journal issue. In that essay, I argued that medicine is best understood not as essentially a curative enterprise, but rather as one essentially oriented towards prediction and understanding. Here, I defend this position from several criticisms made of it.
May 9, 2018: Journal of Medicine and Philosophy
Markus M Lerch
The European Pancreatic Club Lifetime Achievement award is a distinction awarded for research on the pancreas. It comes with the obligation to submit a review article to the society's journal, Pancreatology. Since the research topics of my group have recently been covered in reviews and book chapters I want to use this opportunity to appraise the stations of my clinical and research education, the projects that I pursued and abandoned, the lessons I have learned from them, and the women and men who influenced my training and development as a physician scientist...
June 2018: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
Mathew Mercuri
Clinical practice guidelines (CPGs) and clinical pathways have become important tools for improving the uptake of evidence-based care. Where CPGs are good, adherence to the recommendations within is thought to result in improved patient outcomes. However, the usefulness of such tools for improving patient important outcomes depends both on adherence to the guideline and whether or not the CPG in question is good. This begs the question of what it is that makes a CPG good? In this issue of the Journal, Djulbegovic and colleagues offer a theory to help guide the development of CPGs...
April 17, 2018: Journal of Evaluation in Clinical Practice
Timothy J Hunt, Jefferson C Brand, Michael J Rossi, James H Lubowitz
The 2018 Arthroscopy Association of North America Annual Meeting represents an opportunity to deepen one's understanding of a wide variety of topics. Arthroscopy journal readers have diverse practices and interests, and the meeting is designed to accommodate individual needs. The constructivist learning theory provides that scholars learn in many different ways. Thus, to enrich your learning experience, selected recently published Arthroscopy articles are suggested to supplement material presented at the meeting...
April 2018: Arthroscopy: the Journal of Arthroscopic & related Surgery
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