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https://www.readbyqxmd.com/read/30116725/optimizing-enteral-nutrition-for-growth-in-pediatric-chronic-kidney-disease-ckd
#1
REVIEW
Christina L Nelms
Growth in pediatric Chronic Kidney Disease is important for long-term outcomes including final adult height and cognitive function. However, there are many barriers for children with chronic kidney disease to achieve adequate nutritional intake to optimize growth. This review highlights these unique concerns, including route of nutrition, dialysis contributions and biochemical indices. Fitting the enteral feeding to the patients' needs involves choosing an appropriate product or products, limiting harmful nutrients in excess, notably aluminum, and altering for electrolyte and micronutrient needs...
2018: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/30095668/gender-dysphoria-in-youth-an-overview-for-primary-care-providers
#2
Brayden N Kameg, Donna G Nativio
BACKGROUND AND PURPOSE: Primary care providers who encounter children are often the first line of contact for individuals with gender dysphoria, which occurs when sex assigned at birth is incongruent with one's true, expressed sexual identity. Because those with untreated gender dysphoria are at risk of a variety of negative outcomes, including mood symptomatology, suicidality, substance use disorders, and other psychosocial risk factors, it is critical that health care providers are adept in the provision of holistic, patient-centered care...
August 6, 2018: Journal of the American Association of Nurse Practitioners
https://www.readbyqxmd.com/read/30082544/clinicoepidemiological-profiles-clinical-practices-and-the-impact-of-holistic-care-interventions-on-outcomes-of-pediatric-hematolymphoid-malignancies-a-7-year-audit-of-the-pediatric-hematolymphoid-disease-management-group-at-tata-memorial-hospital
#3
Gaurav Narula, Maya Prasad, Shalini Jatia, Papagudi G Subramanian, Nikhil Patkar, Prashant Tembhare, Dhanlaxmi Shetty, Nehal Khanna, Siddharth Laskar, Tanuja Shet, Sridhar Epari, Seema Kembhavi, Sneha Shah, Sajid Qureshi, Sumeet Gujral, Shripad D Banavali
INTRODUCTION: The Pediatric Hematolymphoid Disease Management Group (PHL-DMG) at a tertiary cancer care hospital developed extensive patient support programs to improve retention and outcomes while focusing on protocols adapted to meet patient needs. An audit of measures and outcomes was done for a 7-year period from January 2010 to December 2016. MATERIALS AND METHODS: DMG protocols and patient support activities over the study period were documented and audited...
October 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/30081442/where-are-you-going-nephrology-considerations-on-models-of-care-in-an-evolving-discipline
#4
Giorgina Barbara Piccoli, Conrad Breuer, Gianfranca Cabiddu, Angelo Testa, Christelle Jadeau, Giuliano Brunori
Nephrology is a complex discipline, including care of kidney disease, dialysis, and transplantation. While in Europe, about 1:10 individuals is affected by chronic kidney disease (CKD), 1:1000 lives thanks to dialysis or transplantation, whose costs are as high as 2% of all the health care budget. Nephrology has important links with surgery, bioethics, cardiovascular and internal medicine, and is, not surprisingly, in a delicate balance between specialization and comprehensiveness, development and consolidation, cost constraints, and competition with internal medicine and other specialties...
August 3, 2018: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/30080803/logistics-of-withdrawal-of-life-sustaining-therapies-in-picu
#5
Karen Dryden-Palmer, Cathy Haut, Samantha Murphy, Patricia Moloney-Harmon
OBJECTIVES: To describe practical considerations and approaches to best practices for end-of-life care for critically ill children and families in the PICU. DATA SOURCES: Literature review, personal experience, and expert opinion. STUDY SELECTION: A sampling of the foundational and current evidence related to the withdrawal of life-sustaining therapies in the context of childhood critical illness and injury was accessed. DATA EXTRACTION: Moderated by the authors and supported by lived experience...
August 2018: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/30077137/customizable-biomaterials-as-tools-for-advanced-anti-angiogenic-drug-discovery
#6
REVIEW
Eric H Nguyen, William L Murphy
The inhibition of angiogenesis is a critical element of cancer therapy, as cancer vasculature contributes to tumor expansion. While numerous drugs have proven to be effective at disrupting cancer vasculature, patient survival has not significantly improved as a result of anti-angiogenic drug treatment. Emerging evidence suggests that this is due to a combination of unintended side effects resulting from the application of anti-angiogenic compounds, including angiogenic rebound after treatment and the activation of metastasis in the tumor...
July 26, 2018: Biomaterials
https://www.readbyqxmd.com/read/30074515/systems-biology-approaches-to-identify-disease-mechanisms-and-facilitate-targeted-therapy-in-the-management-of-glomerular-disease
#7
Habib Hamidi, Matthias Kretzler
PURPOSE OF REVIEW: Current clinical pathological classifications of glomerular diseases are inadequate at predicting patient disease progression or response to therapy. With the advent of precision medicine and its successes in oncology, it is important to understand if similar approaches in glomerular diseases can improve patient management. The purpose of this review is to summarize approaches to obtain comprehensive molecular profiles from human biopsies and utilize them to define the pathophysiology of glomerular failure...
August 1, 2018: Current Opinion in Nephrology and Hypertension
https://www.readbyqxmd.com/read/30066731/statistical-analysis-plan-for-early-goal-directed-therapy-using-a-physiological-holistic-view-the-andromeda-shock-a-randomized-controlled-trial
#8
Glenn Hernández, Alexandre Biasi Cavalcanti, Gustavo Ospina-Tascón, Arnaldo Dubin, Francisco Javier Hurtado, Lucas Petri Damiani, Gilberto Friedman, Ricardo Castro, Leyla Alegría, Maurizio Cecconi, Jean-Louis Teboul, Jan Bakker
BACKGROUND: ANDROMEDA-SHOCK is an international, multicenter, randomized controlled trial comparing peripheral perfusion-targeted resuscitation to lactate-targeted resuscitation in patients with septic shock in order to test the hypothesis that resuscitation targeting peripheral perfusion will be associated with lower morbidity and mortality. OBJECTIVE: To report the statistical analysis plan for the ANDROMEDA-SHOCK trial. METHODS: We describe the trial design, primary and secondary objectives, patients, methods of randomization, interventions, outcomes, and sample size...
July 30, 2018: Revista Brasileira de Terapia Intensiva
https://www.readbyqxmd.com/read/30066265/spiritual-and-religious-healing-practices-some-reflections-from-saudi-national-center-for-complementary-and-alternative-medicine-riyadh
#9
Naseem Akhtar Qureshi, Asim Abdelmoneim Khalil, Saud Mohammad Alsanad
Traditional practices constituting spiritual and religious (S/R) healing are an important component of the holistic healthcare model and are used in health, well-being, and treating a variety of diseases around the world. The main focus of this review is to summarize the Complementary and Alternative Medicine (CAM) studies that especially target S/R healing practices in Saudi Arabia (SA) and discuss the results in light of relevant international literature. From year 2013-2017, electronic searches of PubMed, OvidSP, Google Scholar, and two publishing housing Web sites (Sciencedomain...
July 31, 2018: Journal of Religion and Health
https://www.readbyqxmd.com/read/30065553/non-pharmacological-therapies-for-inflammatory-bowel-disease-recommendations-for-self-care-and-physician-guidance
#10
REVIEW
Whitney Duff, Natasha Haskey, Gillian Potter, Jane Alcorn, Paulette Hunter, Sharyle Fowler
We performed a scoping review on sought-after complementary therapies for patients with inflammatory bowel disease (IBD), specifically diet, physical activity and exercise (PA/E), and psychotherapy. We aim to update patients with IBD on therapies for self-care and provide physicians with guidance on how to direct their patients for the management of IBD. A search of MEDLINE, EMBASE, and PUBMED was completed in Sept 2016. Studies on diet, PA/E, or psychotherapy in patients with IBD were included. Medical Subject Heading terms and Boolean operators were used...
July 28, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/30056925/holistic-long-term-care-over-elderly-kidney-transplant-recipients
#11
E Wlodarczyk, Z Wlodarczyk, L Paczek, A Szymanska, M Glyda, A Adamowicz, G Baczyk, A Ulatowska
Kidney transplantation is an optimal method of renal replacement therapy in patients with phase V chronic kidney disease. Elderly patients (older than 60 years) with a kidney transplant create a significant and constantly growing pool of patients with this type of organ transplantation. In this group of patients, long-term care should be particularly stringent and vigilant. Apart from typical conditions associated with chronic kidney disease and possible post-transplant complications as well as side effects of immunosuppressive treatment, the patient also experiences changes and limitations associated with the progress of age and diseases typical for old age, characterized by a higher risk of infection, and changed pharmacokinetics/pharmacodynamics...
July 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/30047071/longitudinal-changes-in-the-quality-of-life-of-oral-cancer-patients-during-the-perioperative-period
#12
Takayuki Aoki, Yoshihide Ota, Takatsugu Suzuki, Yuya Denda, Ken-Ichi Aoyama, Takeshi Akiba, Mariko Naito, Toshihiro Arai
BACKGROUND: There are few quality of life (QOL) studies that have focused on the experiences of oral cancer patients. Therefore, the present study aimed to investigate how the QOL for patients with oral cancer changed perioperatively. METHODS: Eighty-three participants undergoing radical therapy completed assessments of QOL at pre-treatment, treatment completion, and 1-, 3-, and 6-months post-treatment. The Japanese version of the FACT-H&N, comprising the subscales of "physical well-being (PWB)," "social/family well-being (SWB)," "emotional well-being (EWB)," "functional well-being (FWB)," and "additional head- and neck-specific concerns(HN)" was used to assess QOL...
July 25, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/30042369/comorbidities-complications-and-non-pharmacologic-treatment-in-idiopathic-pulmonary-fibrosis
#13
REVIEW
Paloma Millan-Billi, Candela Serra, Ana Alonso Leon, Diego Castillo
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive and fatal disease. The treatment is challenging and nowadays a comprehensive approach based not only in pharmacological strategies is necessary. Identification and control of comorbidities, non-pharmacological treatment, prevention and management of exacerbations as well as other areas of care (social, psychological) are fundamental for a holistic management of IPF. Gastroesophageal reflux, pulmonary hypertension, obstructive sleep apnea, combined with emphysema, lung cancer and cardiovascular involvement are the main comorbidities associated with IPF...
July 24, 2018: Medical Sciences: Open Access Journal
https://www.readbyqxmd.com/read/30042201/low-level-antimicrobials-in-the-medicinal-leech-select-for-resistant-pathogens-that-spread-to-patients
#14
Lidia Beka, Matthew S Fullmer, Sophie M Colston, Michael C Nelson, Emilie Talagrand-Reboul, Paul Walker, Bradley Ford, Iain S Whitaker, Brigitte Lamy, Johann Peter Gogarten, Joerg Graf
Fluoroquinolones (FQs) and ciprofloxacin (Cp) are important antimicrobials that pollute the environment in trace amounts. Although Cp has been recommended as prophylaxis for patients undergoing leech therapy to prevent infections by the leech gut symbiont Aeromonas , a puzzling rise in Cp-resistant (Cpr ) Aeromonas infections has been reported. We report on the effects of subtherapeutic FQ concentrations on bacteria in an environmental reservoir, the medicinal leech, and describe the presence of multiple antibiotic resistance mutations and a gain-of-function resistance gene...
July 24, 2018: MBio
https://www.readbyqxmd.com/read/30041208/total-renal-care-approach-for-patients-with-end-stage-renal-disease
#15
Yuka Kamijo, Shino Fujimoto, Yoshitaka Ishibashi
BACKGROUND: Advances in dialysis medicine have enabled end-stage renal disease (ESRD) patients to live longer. ESRD patients and their family members experience the illness in everyday life, and patients are required to manage their own disease to live longer. Psychological flexibility benefits a person and leads to healthier outcomes. Constructing an independent-minded attitude toward their lives with ESRD is preferably needed. SUMMARY: Holistic care is needed to see patients with ESRD and their families because they are faced with life-long illness...
2018: Contributions to Nephrology
https://www.readbyqxmd.com/read/30027403/mutual-concessions-and-compromises-between-stromal-cells-and-cancer-cells-driving-tumor-development-and-drug-resistance
#16
REVIEW
Pritish Nilendu, Sachin C Sarode, Devashree Jahagirdar, Ishita Tandon, Shankargouda Patil, Gargi S Sarode, Jayanta K Pal, Nilesh Kumar Sharma
BACKGROUND: Various cancers have been found to be associated with heterogeneous and adaptive tumor microenvironments (TMEs) and to be driven by the local TMEs in which they thrive. Cancer heterogeneity plays an important role in tumor cell survival, progression and drug resistance. The diverse cellular components of the TME may include cancer-associated fibroblasts, adipocytes, pericytes, mesenchymal stem cells, endothelial cells, lymphocytes and other immune cells. These components may support tumor development through the secretion of growth factors, evasion from immune checkpoints, metabolic adaptations, modulations of the extracellular matrix, activation of oncogenes and the acquisition of drug resistance...
July 19, 2018: Cellular Oncology (Dordrecht)
https://www.readbyqxmd.com/read/30015539/defending-the-art-of-physical-therapy-expanding-inquiry-and-crafting-culture-in-support-of-therapeutic-alliance
#17
Nicole Brun-Cottan, Danny McMillian, Jennifer Hastings
The successful practice of physical therapy requires a professional culture that places value on the interpersonal relationships that foster healing, and the face time required to build those relationships. Pressures on current practice are not facilitating this approach. The drive for increased productivity, cost effectiveness and ultimately, profit, are changing the landscape in which we practice. This phenomenon is fueled by an overemphasis on quantitative research in evidence-based medicine and an underappreciation of clinical expertise and patient values...
July 17, 2018: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/29998539/promoting-functional-independence-in-people-with-alzheimer-s-disease-outcomes-of-a-home-based-occupational-therapy-intervention-in-spain
#18
Adriana Ávila, Iván De-Rosende-Celeiro, Gabriel Torres, Mirian Vizcaíno, Manuel Peralbo, Montserrat Durán
Nonpharmacologic therapies such as occupational therapy (OT) are promising for people with Alzheimer's disease (AD). However, more research is needed to better understand the effectiveness of home-based OT programs. This pilot study aimed to assess the effects of a home-based, high-intensity and multicomponent OT intervention on the activities of daily living of people with AD in Spain. The secondary objective was to examine its impact on the cognitive functions. A multiple-baseline intrasubject design was used...
July 11, 2018: Health & Social Care in the Community
https://www.readbyqxmd.com/read/29990850/appraisal-of-mechanisms-of-radioprotection-and-therapeutic-approaches-of-radiation-countermeasures
#19
REVIEW
Krishna N Mishra, Belal A Moftah, Ghazi A Alsbeih
Radiation countermeasures are radioprotective agents that reduce the harmful effects of ionizing radiation. They have wide range of applications extending from protection of normal tissues of cancer patients during radiotherapy to safeguard people aftermath of radiologic or nuclear accidents. Despite the screening of thousands of natural and synthetic compounds, only few found place in clinic with limited tolerance. Therefore, mechanistic understanding is essential in the development of more suitable and customized radiation countermeasure agents...
July 3, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29989063/oncograms-visualize-factors-influencing-long-term-survival-of-cancer-patients-treated-with-adenoviral-oncolytic-immunotherapy
#20
Otto Hemminki, Minna Oksanen, Kristian Taipale, Ilkka Liikanen, Anniina Koski, Timo Joensuu, Anna Kanerva, Akseli Hemminki
The first US Food and Drug Administration (FDA)- and EMA-approved oncolytic virus has been available since 2015. However, there are no markers available that would predict benefit for the individual patient. During 2007-2012, we treated 290 patients with advanced chemotherapy-refractory cancers, using 10 different oncolytic adenoviruses. Treatments were given in a Finnish Medicines Agency (FIMEA)-regulated individualized patient treatment program (the Advanced Therapy Access Program [ATAP]), which required long-term follow-up of patients, which is presented here...
June 29, 2018: Molecular Therapy Oncolytics
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