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https://www.readbyqxmd.com/read/30315848/clinical-solutions-to-chronic-pain-and-the-opiate-epidemic
#1
REVIEW
Matthew Murray, Alexander Stone, Virginia Pearson, Glenn Treisman
The current opiate epidemic has caused tens of thousands of deaths annually and hundreds of billions in economic losses. From 1979 to 2015, accidental opiate-related deaths increased by 4250%. Despite its magnitude, the driving forces remain poorly understood. A narrow understanding by physicians, administrators, and policy makers has resulted in a clinical approach to chronic pain treatment misguided by expediency, shortsighted cost reduction, pharmaceutical profit, and patient satisfaction. Until the broken elements are well understood, effective policy solutions will remain elusive...
October 10, 2018: Preventive Medicine
https://www.readbyqxmd.com/read/30298012/a-computational-framework-to-benchmark-basket-catheter-guided-ablation-in-atrial-fibrillation
#2
Martino Alessandrini, Maddalena Valinoti, Laura Unger, Tobias Oesterlein, Olaf Dössel, Cristiana Corsi, Axel Loewe, Stefano Severi
Catheter ablation is a curative therapeutic approach for atrial fibrillation (AF). Ablation of rotational sources based on basket catheter measurements has been proposed as a promising approach in patients with persistent AF to complement pulmonary vein isolation. However, clinically reported success rates are equivocal calling for a mechanistic investigation under controlled conditions. We present a computational framework to benchmark ablation strategies considering the whole cycle from excitation propagation to electrogram acquisition and processing to virtual therapy...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/30293711/supporting-supportive-care-in-cancer-the-ethical-importance-of-promoting-a-holistic-conception-of-quality-of-life
#3
REVIEW
D Carrieri, F A Peccatori, G Boniolo
Advances in anticancer therapies and increasing attention towards patient quality of life make Supportive Care in Cancer (SCC) a key aspect of excellence in oncological care. SCC promotes a holistic conception of quality of life encompassing clinical, ethical/existential, and spiritual dimensions. Despite the calls of international oncology societies empirical evidence shows that SCC has not yet been implemented. More efforts are needed given the clinical and ethical value of SCC not only for patients, but also for clinicians and hospitals...
November 2018: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/30283708/orthogonal-stimulus-response-as-a-tool-to-formulate-traditional-chinese-medicinal-herbal-combination-new-scientific-based-tcm-herbal-formulating-method
#4
Yean Chun Loh, Chu Shan Tan, Mun Fei Yam, Chuan Wei Oo, Wan Maznah Wan Omar
Objectives: There is an increasing number of complex diseases that are progressively more difficult to be controlled using the conventional "single compound, single target" approach as demonstrated in our current modern drug development. TCM might be the new cornerstone of treatment alternative when the current treatment option is no longer as effective or that we have exhausted it as an option. Orthogonal stimulus-response compatibility group study is one of the most frequently employed formulas to produce optimal herbal combination for treatment of multi-syndromic diseases...
September 2018: Journal of Pharmacopuncture
https://www.readbyqxmd.com/read/30283608/-treat-patient-not-just-the-disease-holistic-needs-assessment-for-haematological-cancer-patients
#5
Md Serajul Islam
Haematological malignancies can have devastating effects on the patients' physical, emotional, psycho-sexual, educational and economic health. With the improvement of therapies patients with these malignancies are living longer, however significant proportion these patient show poor quality of life (QoL) due to various physical and psychological consequences of the disease and the treatments. Health-related QoL (HRQoL) is multi-dimensional and temporal, relating to a state of functional, physical, psychological and social/family well-being...
July 4, 2018: Oncology Reviews
https://www.readbyqxmd.com/read/30281752/-between-doctors-and-healers-managing-meanings-and-practices-of-the-health-disease-care-process-in-an-argentine-catholic-charismatic-movement
#6
Ana Lucía Olmos Álvarez
This work describes and analyzes the trajectories and strategies in the search for healing among participants of a charismatic Catholic healing movement in Argentina. Using ethnographic research carried out between July 2009 and April 2015, the article focuses on conceptions, practices and experiences surrounding health-disease-care processes. It is highlighted that disease management requires both a cognitive and a practical response, in this case involving two primary therapeutic resources: biomedicine and religious therapies...
April 2018: Salud Colectiva
https://www.readbyqxmd.com/read/30276835/antiviral-compound-screening-peptide-designing-and-protein-network-construction-of-influenza-a-virus-strain-a-puerto-rico-8-1934-h1n1
#7
Surovi Saikia, Manobjyoti Bordoloi, Rajeev Sarmah, Bhaskor Kolita
Hit, Lead & Candidate Discovery Plant-based antiviral therapy is the current need for holistic health care management, which can be achieved through screening of phytochemicals and designing of antiviral peptides. There exist certain host's factors which are directly involved for rapid viral replication causing worldwide pandemic. A total of 177 phytochemicals from Ocimum sanctum (L.), Tinospora cordifolia (Thunb.) Miers, Cinnamomum camphora (L.) J. Presl., Allium sativum (L.), Curcuma longa (L.), and Aloe vera (L...
October 1, 2018: Drug Development Research
https://www.readbyqxmd.com/read/30270628/the-in-depth-venome-of-the-brazilian-rattlesnake-crotalus-durissus-terrificus-an-integrative-approach-combining-its-venom-gland-transcriptome-and-venom-proteome
#8
Gisele Adriano Wiezel, Priscila Yumi Tanaka Shibao, Camila Takeno Cologna, Romualdo Morandi Filho, Carlos Ueira-Vieira, Edwin De Pauw, Loïc Quinton, Eliane C Arantes
Snake venoms are complex mixtures mainly composed of proteins and small peptides. Crotoxin is one of the most studied components from Crotalus venoms, but many other components are less known due to their low abundance. The venome of Crotalus durissus terrificus, the most lethal Brazilian snake, was investigated combining its venom gland transcriptome and proteome to create a holistic database of venom compounds unraveling novel toxins. We constructed a cDNA library from C. d. terrificus venom gland using the Illumina platform and investigated its venom proteome through high resolution LC-MS/MS...
October 1, 2018: Journal of Proteome Research
https://www.readbyqxmd.com/read/30248242/female-type-of-adult-acne-physiological-and-psychological-considerations-and-management
#9
REVIEW
Brigitte Dreno, Edileia Bagatin, Ulrike Blume-Peytavi, Marco Rocha, Harald Gollnick
Today we see more cases of acne after adolescence, with a greater prevalence in females than males. Adult female acne has a distinct clinical presentation and is associated with a number of specific pathophysiological features and gender-specific triggers. The psychological impact of acne is generally significant and largely underestimated; stress during professional and private life, anxiety and sleep quality, in particular, have a reciprocal relationship with disease susceptibility and severity. It is essential to compare with males...
October 2018: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/30244777/a-qualitative-assessment-of-health-behaviors-and-experiences-during-menopause-a-cross-sectional-observational-study
#10
Kara L Marlatt, Robbie A Beyl, Leanne M Redman
OBJECTIVES: A qualitative research study was performed to assess the health and lifestyle behaviors of middle-aged women during the menopause transition, as well as to inform the development of interventions designed to combat menopause symptoms and improve quality of life during and after menopause. STUDY DESIGN: Data were collected from 1611 women via a 21-item questionnaire distributed electronically. Only women who self-reported age ≥40 years and who were either peri-menopausal or post-menopausal were included in the analyses...
October 2018: Maturitas
https://www.readbyqxmd.com/read/30233109/multimodal-therapy-holistic-approach
#11
EDITORIAL
T M Srinivasan
No abstract text is available yet for this article.
September 2018: International Journal of Yoga
https://www.readbyqxmd.com/read/30225779/development-and-characterization-of-novel-medicated-nanofiber-for-the-treatment-of-periodontitis
#12
Amar Deepak, Amit K Goyal, Goutam Rath
Periodontitis is a common microbial infection that involves pocket formation due to the destruction of periodontal ligament. The present work is oriented to provide a holistic approach for the treatment of periodontitis comprising localized delivery of nanometric hydroxyapatite as a reinforcing filler and silver-metronidazole as periodontal pocket disinfectant adjunct to current periodontal therapy because of its broad-spectrum antimicrobial activity and low systemic toxicity. In the present work, electrospinning technique was used to prepare medicated nanofiber enriched with antibacterial-hydroxyapatite layers for dental application...
September 17, 2018: AAPS PharmSciTech
https://www.readbyqxmd.com/read/30225635/what-can-we-learn-from-unaccompanied-refugee-adolescents-perspectives-on-mental-health-care-in-exile
#13
Frederikke Jarlby, Simone Goosen, Ilse Derluyn, Kathrine Vitus, Signe Smith Jervelund
Unaccompanied refugee adolescents who have fled war and persecution often have poor mental health. Yet, little is known about their own perspectives on what can relieve their mental health problems. The aim was to explore unaccompanied refugee adolescents' perspectives on healing and the mental healthcare offered to them when resettled. The study was based on methodical triangulation of participant observation in a Danish municipal institution for unaccompanied refugee minors, semi-structured individual interviews with experts, social workers and male refugee minors and a focus group interview with refugee minors...
September 17, 2018: European Journal of Pediatrics
https://www.readbyqxmd.com/read/30225572/establishing-an-integrative-oncology-service-in-the-australian-healthcare-setting-the-chris-o-brien-lifehouse-hospital-experience
#14
Suzanne J Grant, Michael Marthick, Judith Lacey
Comprehensive cancer centres are on the rise as patients seek a more holistic approach to maintaining their wellbeing when living with a cancer diagnosis. Many cancer centres worldwide now incorporate a selection of evidence-based complementary therapies and qualified therapists into their offerings. The Chris O'Brien Lifehouse, a comprehensive cancer centre in Sydney, Australia, provides integrative oncology services including acupuncture, massage, reflexology, dietetics and exercise physiology for individual patients, along with group programmes, and an integrative and supportive care medical specialist...
September 17, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/30219468/differences-between-vegetarian-and-omnivorous-yoga-practitioners-results-of-a-nationally-representative-survey-of-us-adult-yoga-practitioners
#15
Holger Cramer, Tobias Sundberg, Dania Schumann, Matthew J Leach, Romy Lauche
BACKGROUND: To examine the prevalence of vegetarianism among yoga practitioners, and to explore differences and similarities between yoga practitioners who also use vegetarian diet and those who do not. DESIGN AND SETTING: Using cross-sectional data from the 2012 National Health Interview Survey (NHIS) (N = 34,525), weighted frequencies for 12-month prevalence of vegetarian diet use among yoga practitioners were analyzed. Logistic regression analyses were used to analyze sociodemographic and clinical predictors of vegetarian diet use...
October 2018: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/30215719/examination-of-an-integrative-health-care-model-for-social-work-practice
#16
Michelle D DiLauro
Social work professionals would benefit by including integrative medicine programs and practices in their framework of practice and service delivery to clients. In our rapidly changing health care environment, using a model that provides a more comprehensive and empowering approach to addressing the medical and psychological needs of our clients is warranted. Discussion of holistic social work practice and implications for social work education and training will be examined through a review of the research and clinical application of a mind-body program titled the Relaxation Response Resiliency Program (3RP)...
September 12, 2018: Health & Social Work
https://www.readbyqxmd.com/read/30194834/development-and-preliminary-assessment-of-interprofessional-education-focused-on-vulnerable-populations
#17
Celia Pechak, Connie Summers, Barbara Schoen, Margie Padilla, Patricia Lara, Joanna Velasco, Stephanie Capshaw
With the current state of the U.S. healthcare system, interprofessional collaborative practice (IPCP) has never been more important. Health professions educators are increasingly incorporating interprofessional education (IPE) in their curricula in order to prepare students for IPCP. The Health- Focused IPE Community of Practice (representing nursing, occupational therapy, pharmacy, physical therapy, rehabilitation counseling, social work, and speech-language pathology) at the University of Texas at El Paso has created a unique IPE model centered on vulnerable populations...
2018: Journal of Allied Health
https://www.readbyqxmd.com/read/30193961/an-integrated-study-on-tfs-and-mirnas-in-colorectal-cancer-metastasis-and-evaluation-of-three-co-regulated-candidate-genes-as-prognostic-markers
#18
Elaheh Eskandari, Frouzandeh Mahjoubi, Jamshid Motalebzadeh
Molecular alterations that occur in cancer have the potential to be considered as either cancer biomarkers or targeted therapies or even both. In the presented study, we aimed to elucidate the gene regulatory network of metastatic colorectal cancer using data acquired from microarrays to reach the most common DEGs in colorectal cancer metastasis and find their possible regulatory mechanism by DETFs and DEmiRs. In this regards, seven microarray datasets were employed to assess the most important DEGs, DETFs and DEmiRs in colorectal cancer metastasis...
September 4, 2018: Gene
https://www.readbyqxmd.com/read/30191184/reaching-a-consensus-on-research-priorities-for-supporting-women-with-autoimmune-rheumatic-diseases-during-pre-conception-pregnancy-and-early-parenting-a-nominal-group-technique-exercise-with-lay-and-professional-stakeholders
#19
Rhiannon Phillips, Denitza Williams, Daniel Bowen, Delyth Morris, Aimee Grant, Bethan Pell, Julia Sanders, Ann Taylor, Ernest Choy, Adrian Edwards
Background: Women with autoimmune rheumatic diseases (ARDs) find it difficult to get information and support with family planning, pregnancy, and early parenting. A systematic approach to prioritising research is required to accelerate development and evaluation of interventions to meet the complex needs of this population.  Methods: A Nominal Group Technique (NGT) exercise was carried out with lay and professional stakeholders (n=29). Stakeholders were prepared for debate through presentation of available evidence...
2018: Wellcome Open Research
https://www.readbyqxmd.com/read/30186274/metabolic-reprogramming-of-clostridioides-difficile-during-the-stationary-phase-with-the-induction-of-toxin-production
#20
Julia D Hofmann, Andreas Otto, Mareike Berges, Rebekka Biedendieck, Annika-Marisa Michel, Dörte Becher, Dieter Jahn, Meina Neumann-Schaal
The obligate anaerobe, spore forming bacterium Clostridioides difficile (formerly Clostridium difficile ) causes nosocomial and community acquired diarrhea often associated with antibiotic therapy. Major virulence factors of the bacterium are the two large clostridial toxins TcdA and TcdB. The production of both toxins was found strongly connected to the metabolism and the nutritional status of the growth environment. Here, we systematically investigated the changes of the gene regulatory, proteomic and metabolic networks of C...
2018: Frontiers in Microbiology
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