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Holistic therapies

Akshya Vasudev, Susana G Torres-Platas, Karin Kerfoot, Angela Potes, Joseph Therriault, Anthony Gifuni, Marilyn Segal, Karl J Looper, Vasavan Nair, Helen Lavretsky, Soham Rej
BACKGROUND: Current pharmacological treatments and psychotherapeutic approaches often have adverse effects or ineffective in late-life cognitive and mental illnesses. Mind-body interventions offer a holistic approach and are of interest because of potential patient acceptability and scalability. OBJECTIVE: To synthesize current evidence on mind-body interventions in treating or preventing mental illnesses and cognitive disorders in older adults. SEARCH STRATEGY: A search was conducted using Ovid MEDLINE, EMBASE, and PsycINFO articles published from 1993 to 2017...
November 3, 2018: American Journal of Geriatric Psychiatry
Li Duan, Long Guo, Lei Wang, Qiang Yin, Chen-Meng Zhang, Yu-Guang Zheng, E-Hu Liu
Traditional Chinese medicines (TCM) have a long history of use because of its potential complementary therapy and fewer adverse effects. However, the toxicity and safety issues of TCM have drawn considerable attention in the past two decades. Metabolomics is an "omics" approach that aims to comprehensively analyze all metabolites in biological samples. In agreement with the holistic concept of TCM, metabolomics has shown great potential in efficacy and toxicity evaluation of TCM. Recently, a large amount of metabolomic researches have been devoted to exploring the mechanism of toxicity induced by TCM, such as hepatotoxicity, nephrotoxicity, and cardiotoxicity...
2018: Chinese Medicine
Guglielmo Gallone, Luca Baldetti, Matteo Pagnesi, Azeem Latib, Antonio Colombo, Peter Libby, Francesco Giannini
Following an acute coronary syndrome (ACS), heightened predisposition to atherothrombotic events may persist for years. Advances in understanding the pathobiology that underlies this elevated risk furnish a mechanistic basis for devising long-term secondary prevention strategies. Recent progress in ACS pathophysiology has challenged the focus on single "vulnerable plaques" and shifted toward a more holistic consideration of the "vulnerable patient," thus highlighting the primacy of medical therapy in secondary prevention...
December 11, 2018: Journal of the American College of Cardiology
Svetlana Solgaard Nielsen, Jeanette Reffstrup Christensen
Background: Worldwide obesity rates are increasing. The effectiveness of occupational therapy in overweight and obese adults has not yet been clarified. Objectives: The scoping review aimed at examining the evidence on interventions involving occupational therapists in the treatment of adults with overweight and obesity. Methods: Data on interventions involving occupational therapists and reporting on lifestyle-related outcomes in overweight and obese adults was extracted from the databases Cochrane, PubMed, CINAHL, and Embase, including hand and reference search...
2018: Occupational Therapy International
Joseph A Marsh, Matthew I Wagshol, Kyle J Boddy, Michael E O'Connell, Sam J Briend, Kyle E Lindley, Alex Caravan
Background: Weighted-baseball training programs are used at the high school, collegiate, and professional levels of baseball. The purpose of this study was to evaluate the effects of a six-week training period consisting of weighted implements, manual therapy, weightlifting, and other modalities on shoulder external rotation, elbow valgus stress, pitching velocity, and kinematics. Hypothesis: A six-week training program that includes weighted implements will increase pitching velocity along with concomitant increases in arm angular velocities, joint kinetics, and shoulder external rotation...
2018: PeerJ
Tyrone G Harrison, Helen Tam-Tham, Brenda R Hemmelgarn, Matthew T James, Aynharan Sinnarajah, Chandra M Thomas
RATIONALE & OBJECTIVE: Conservative kidney management is holistic patient-centered care for patients with kidney failure that focuses on delaying the progression of kidney disease and symptom management, without the provision of renal replacement therapy. Currently there is no consensus as to what constitutes high-quality conservative kidney management. We aimed to develop a set of quality indicators for the conservative management of kidney failure. STUDY DESIGN: Nominal group technique and Delphi survey process...
October 25, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
Wenjie Song, Shenglou Ni, Yanling Fu, Yun Wang
Maxing Ganshi Decoction (MXGSD) is used widely for asthma over thousands of years, but its underlying pharmacological mechanisms remain unclear. In this study, systematic and comprehensive network pharmacology was utilized for the first time to reveal the potential pharmacological mechanisms of MXGSD on asthma. Specifically, we collected 141 bioactive components from the 600 components in MXGSD, which shared 52 targets common to asthma-related ones. In-depth network analysis of these 52 common targets indicated that asthma might be a manifestation of systemic neuro-immuno-inflammatory dysfunction in the respiratory system, and MXGSD could treat asthma through relieving airway inflammation, improving airway remodeling, and increasing drug responsiveness...
November 26, 2018: Scientific Reports
Rashmi K Ambasta, Rohan Gupta, Dhiraj Kumar, Saurabh Bhattacharya, Aditi Sarkar, Pravir Kumar
Diabetes and colon cancer are the leading cause of mortality worldwide. According to World Health Organization, the number of patients with diabetes and cancer is going to be elevated by 50% in 2020. However, several flavonoids have been known to be useful in reducing the chance of cancer/diabetes but the hunt of a single biomolecule that can act as therapeutic and preventive molecules for future epidemic continues. In this review, we aim to perform an illustration of all researches done that target molecular signaling using luteolin in cancer/diabetes and predicted target protein using PharmMapper...
November 21, 2018: Briefings in Functional Genomics
Chieko Fujisaki
AEON-HO (Altering emotional organization-holistic operation) contains methods of Naikan therapy and mindfulness. Naikan and mindfulness are originally from Buddhism tradition, and they have a high affinity. AEON-HO was conceptualized to improve attachment issues and the growth of self-actualization, because Naikan and mindfulness are known to be effective for attachment issues but partially if they are used independently. Naikan can approach to attachment avoidance, while mindfulness can approach to attachment anxiety...
November 20, 2018: Psychological Reports
Missy Hall, Susanne M Bifano, Leigh Leibel, Linda S Golding, Shiu-Lin Tsai
Pediatric integrative therapy programs are essential to the treatment and well-being of patients. Identifying an effective integrative therapy model within conventional pediatric medical settings, however, often proves difficult. Our goal in this article is to explore varied solutions to increase access and inclusion of integrative therapies in an effort to promote best practice and holistic care. The main methods applied in this article are vignettes that illustrate how the integrative therapies in a metropolitan academic hospital successfully treat the patient by complementing conventional medicine...
November 16, 2018: Children
Mitchell Bailey, Nicole Miller
BACKGROUND: Duchenne muscular dystrophy (Duchenne) is caused by pathogenic variants in the DMD gene. Antisense oligonucleotides (AONs) are one emerging precision medicine treatment for Duchenne. DMD molecular genetic testing results guide precision-therapy molecular eligibility, requiring healthcare providers to perform analyses currently uncommon in clinical laboratory and medical practices. Clear DMD variant notation and interpretation are key components of clinical care with the availability of precision medicine...
November 18, 2018: Molecular Genetics & Genomic Medicine
Clark D Kebodeaux
OBJECTIVE: Nonprescription or over-the-counter (OTC) medications play a crucial role in a patient's ability to make choices to manage his or her own health care. Often these nonprescription choices are unknown to health care practitioners and thus are often not included as part of patients' health records. The exclusion of these therapies can pose risks to patient safety. There is a significant need to address the capture of OTC medication use in both the physician and pharmacy electronic health records (EHRs) and during the practitioner-patient medication history and reconciliation process...
November 14, 2018: Journal of the American Pharmacists Association: JAPhA
Justin Gatwood, Kenneth C Hohmeier, Ian M Brooks
OBJECTIVE: To describe opportunities for pharmacists to use mobile messaging and real-time monitoring to engage with patients taking long-term medications. SUMMARY: The proliferation of mobile phone use across the United States has been met with increased application of these devices by the medical community. However, beyond simple text messages and app-based functions, use of these devices by pharmacies and pharmacists has not been leveraged to improve patient outcomes, such as medication adherence...
November 14, 2018: Journal of the American Pharmacists Association: JAPhA
Steven Chow, Chew Swee Seow, Maria Victoria Dizon, Kiran Godse, Henry Foong, Vicheth Chan, Tran Hau Khang, Leihong Xiang, Syarief Hidayat, M Yulianto Listiawan, Danang Triwahyudi, Srie Prihianti Gondokaryono, Endang Sutedja, Inne Arline Diana, Oki Suwarsa, Hartati Purbo Dharmadji, Agnes Sri Siswati, Retno Danarti, Retno Soebaryo, Windy Keumala Budianti
Background: Atopic dermatitis (AD) is a common skin condition among Asians. Recent studies have shown that Asian AD has a unique clinical and immunologic phenotype compared with European/American AD. Objective: The Asian Academy of Dermatology and Venereology Expert Panel on Atopic Dermatitis developed this reference guide to provide a holistic and evidence-based approach in managing AD among Asians. Methods: Electronic searches were performed to retrieve relevant systematic reviews and guidelines on AD...
October 2018: Asia Pacific Allergy
Beste Turanli, Kubra Karagoz, Gizem Gulfidan, Raghu Sinha, Adil Mardinoglu, Kazim Yalcin Arga
A complex framework of interacting partners including genetic, proteomic, and metabolic networks that cooperate to mediate specific functional phenotypes drives human biological processes. Recent technological and analytical advances in "omic" sciences allow the identification and elucidation of reprogramming biological functions in response to perturbations in cells and tissues. To understand such a complex system, biological networks are generated to reduce the complexity into relatively simple models, and the integration of these molecular networks from different perspectives is implemented for a holistic interpretation of the entire system...
November 5, 2018: Current Pharmaceutical Design
Judith Lacey, Anna J Lomax, Catriona McNeil, Michael Marthick, David Levy, Steven Kao, Theresa Nielsen, Haryana M Dhillon
INTRODUCTION: Increasing numbers of metastatic melanoma (MM) patients are receiving immunotherapy treatment, including pembrolizumab, and the impact on their well-being is underexplored. OBJECTIVES: To assess the feasibility of a multimodal supportive care program to MM patients being treated with pembrolizumab. METHODS: This pre-post-test feasibility cohort study recruited MM participants treated with pembrolizumab: (i) supportive care intervention with usual care and (ii) usual care...
November 3, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
Rebecca Haberman, Lourdes M Perez-Chada, Joseph F Merola, Jose Scher, Alexis Ogdie, Soumya M Reddy
PURPOSE OF REVIEW: Despite a robust therapeutic landscape, significant gaps exist in the quality of care of psoriatic disease. Thus, an improved understanding of the challenges in providing quality care and the implementation of effective strategies to overcome them is needed. In this review, we summarize the burden of psoriatic disease, discuss the challenges in the care of psoriatic patients, and outline how combined dermatology-rheumatology clinics bridge many of these gaps. RECENT FINDINGS: Multiple challenges are faced in providing high-quality care to patients with psoriasis and psoriatic arthritis from the pre-diagnosis phase of disease to the follow-up period...
October 26, 2018: Current Rheumatology Reports
Corinne E Metzger, S Anand Narayanan, David C Zawieja, Susan M Bloomfield
Inflammatory bowel disease is a condition that leads to gut pathologies, such as abnormal lymphatic architecture, as well as systemic comorbidities such as bone loss. Furthermore, current therapies are limited to low efficacy and incur side-effects. Dietary interventions are minimally explored, but may provide a holistic treatment to improve gut outcomes and comorbidities. Indeed, plant-based soy protein has been shown to exert anti-inflammatory effects. Here we tested the impact of a moderately elevated soy protein diet in a chronic, TNBS-induced colitis model on gut and bone inflammatory-mediated pathophysiological adaptations...
October 23, 2018: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
Katie Cooke, Sharon K Millard
Purpose: The aim of this article was to identify what school-aged children who stutter consider to be the most important outcomes from therapy. Method: A Delphi approach was employed for the study. Eighteen participants aged 9-13 years completed a survey, generating 90 statements that would constitute successful therapy outcomes. After categorization and reduction, 79 statements were sent to participants in a second survey to seek consensus on their importance. Fifteen participants aged 8-14 years completed this second survey...
October 19, 2018: American Journal of Speech-language Pathology
Flavia DeSouza, Elijah Paintsil, Teisha Brown, Russell Pierre, Danya Keene, Nancy Kim, Celia Christie
Increasing access to antiretroviral therapy in resource-limited settings (RLS) has resulted in the survival of perinatally HIV-infected children into adulthood. We characterized the transition process from pediatric to adult care by conducting semi-structured interviews of HIV-infected adolescents and health care providers in Jamaica. Using an inductive content analytic approach, four themes emerged: (1) Transition should be holistic and a process; (2) Pediatric clinics were like families; (3) Rootedness in the pediatric clinic; and (4) Need for adolescent-centered services to bridge the gap between pediatric and adult-centered services...
October 20, 2018: AIDS Care
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