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Safe sleep

Gianni Belcaro, Roberta Luzzi, Morio Hosoi, Mark Dugall, Maria Rosaria Cesarone
BACKGROUND: Post-traumatic stress disorder (PTSD) is associated to recurrent, obsessive recollection of severe traumatic events. This condition is still not completely understood. Elective treatment of PTSD is psychotherapy. Standardized supplements, used for improving chronic fatigue syndrome (i.e. Robuvit®, Horphag Research Ltd) can also be used to control some of the symptoms associated to PTSD, as well as to control the associated increased oxidative stress, present in many of these patients...
October 2018: Minerva Medica
Jacqui Wise
No abstract text is available yet for this article.
October 17, 2018: BMJ: British Medical Journal
C Capittini, A De Silvestri, M Terzaghi, V Scotti, C Rebuffi, A Pasi, R Manni, M Martinetti, C Tinelli
STUDY OBJECTIVES: we performed a meta-analysis to assess the usefulness of HLA testing for Narcolepsy diagnosis in four major ethnical groups: Asians, Afro-Americans, Amerindians and Caucasians. METHODS: PubMed, EMBASE, Web of Science, Scopus and Cochrane databases were searched for articles in English and French published before October 2017 on HLA class II alleles in Narcolepsy. We included case-control studies, cross-sectional and retrospective cohort studies with patients diagnosed following the International classifications of sleep disorders (1990-2012) and ethnically matched controls...
September 20, 2018: Sleep Medicine
Alexander C Whiting, Elizabeth F Sutton, Corey T Walker, Jakub Godzik, Joshua S Catapano, Michael Y Oh, Nestor D Tomycz, Eric Ravussin, Donald M Whiting
OBJECTIVE: Obesity has become a worldwide epidemic, with very few long-term successful treatment options for refractory disease. Deep brain stimulation (DBS) of the bilateral lateral hypothalamus (LH) in refractory obesity has been performed safely, but questions remain regarding optimal settings and its effects on metabolic rate. The goals of this experiment were to determine optimal DBS settings and then to determine the actual effect of optimal stimulation on energy expenditure. METHODS: Following bilateral LH DBS implantation, two subjects with treatment refractory obesity underwent four days of metabolic testing...
October 10, 2018: World Neurosurgery
K-U Kern, M Schwickert-Nieswandt
A 68-year-old patient suffered from postzoster neuralgia with severe pain of the left trigeminal nerve V1. Despite medication with gabapentin 1800 mg/d, oxacarbazepine 600 mg, tapentadol 500 mg/d, amitriptyline 20 mg as well as ambroxol 20% ointment and lidocaine patch topically, the pain reached an intensity of 8-10 on the numeric rating scale (NRS). Wearing a CPAP (continuous positive airway pressure) mask at night to treat a sleep apnea was impossible or the mask was leaking under lidocaine patch, only topical ambroxol 20% brought a certain pain relief...
October 10, 2018: Der Schmerz
Mazal Maged, Denise Rizzolo
Sleep-related sudden unexpected infant death (SUID), including sudden infant death syndrome, remains the leading cause of postneonatal mortality in the United States and the third leading cause of infant death overall. Despite the evidence-based risk-reduction strategies and the highly publicized campaigns for a safe sleep environment, some infants continue to sleep in unsafe sleep conditions. Clinicians need to know the current best practices to reduce the incidence of sleep-related SUID and be knowledgeable to counsel caregivers who may resist adhering to these recommendations...
October 9, 2018: JAAPA: Official Journal of the American Academy of Physician Assistants
Shu Hu, Gianni Belcaro, Andrea Ledda, Marcello Corsi, Roberto Cotellese, Beatrice Feragalli, Morio Hosoi, Mark Dugall, Patrizia Torino-Rodriguez, Maria R Cesarone
BACKGROUND: Infectious mononucleosis (IM) is a common disease of adolescents and young adults, characterized by a specific triad of symptoms represented by fever, sore throat and lymphadenopathy. IM may also affect older adults, with different, more intense signs and symptoms such as fatigue, general malaise, and diffuse body pain. The aim of this four-week-registry was to evaluate the effects of Robuvit® supplementation on the main consequences of mononucleosis, particularly fatigue, in otherwise healthy adults...
October 2018: Minerva Pediatrica
Alessandra Glover Williams, Fiona Finlay
Clinical scenario: A mother brought her infant to the hospital with bronchiolitis and incidentally asked if I would recommend the use of infant sleeping bags to protect against Sudden Infant Death Syndrome as several of her friends use them. Structured question: Can infant sleeping bags be recommended by medical professionals as protective against Sudden Infant Death Syndrome? METHODS: A literature search was performed. Trials were included if they had an English version available and the papers examined the impact that sleeping bag use had on risk of SIDS or its risk factors...
October 8, 2018: Archives of Disease in Childhood
Nicholas J Scalzitti, Kathleen M Sarber
Sleep-disordered breathing has a prevalence of 12% in the pediatric population. It represents a spectrum of disorders encompassing abnormalities of the upper airway that lead to sleep disruption, including primary snoring, obstructive sleep apnea, central sleep apnea, and sleep-related hypoventilation. Sleep-disordered breathing is the most common indication for adenotonsillectomy, one of the most common procedures performed in children. In recent years, the American Academy of Otolaryngology-Head and Neck Surgery, American Academy of Pediatrics, and the American Society of Anesthesiologists have crafted guidelines to help safely manage children with sleep-disordered breathing...
October 3, 2018: Paediatric Anaesthesia
Yaxuan Liu, Yangyang Ying, Jaffar S Pandu, Yan Wang, Shuang Dou, Yanzhong Li, Dedong Ma
OBJECTIVE: We have designed the expiratory positive airway pressure (EPAP) mask to provide a new sort of therapeutic strategies for Obstructive Sleep Apnea Hypopnea Syndrome (OSAHS). And this study aims to assess the safety, efficacy and compliance of the EPAP therapy. METHODS: 40 healthy volunteers were enrolled to measure the end-tidal carbon dioxide pressure (PETCO2 ) while being treated by EPAP mask. 40 symptomatic moderate or severe OSAHS patients (AHI≥15/h) recruited were equally divided into two groups randomly and treated with CPAP or mask for a week respectively...
September 24, 2018: Auris, Nasus, Larynx
Yang Zhou, Changbin Li, Feng Jin, Hongfang Shao, Yincheng Teng, Minfang Tao
AIM: To investigate the prevalence and predictors of sexual frequency, sexual desire in midlife partnered Chinese women. METHODS: Sexual frequency, sexual desire over the past 3 months, menopausal symptoms and other socioeconomic information were assessed for women aged 40-65 years in the Shanghai Sixth People's Hospital. RESULTS: Among 3485 eligible partnered participants, the prevalence of low sexual frequency (less than once per week) and low sexual desire (less than 5 scores) were 72...
September 27, 2018: Journal of Obstetrics and Gynaecology Research
Valentina Pinto, Ottavio Piccin
No abstract text is available yet for this article.
September 6, 2018: Plastic and Reconstructive Surgery
Sergio Susmallian, Royi Barnea, Yossi Weiss, Asnat Raziel
BACKGROUND: People are living longer than they were expected to 2 decades ago. Increased life expectancy and reduced mortality encompasses a simultaneous increase in the number of older adults with obesity that entails an increase of co-morbidities, such as diabetes, hypertension, cancer, and many other diseases. The aim of our study was to compare the outcomes of bariatric surgery in patients age ≥65 in comparison with younger patients. METHODS: This retrospective study compares bariatric surgeries performed in a private institution between the years 2013 and 2015...
August 11, 2018: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
Ryan Charles Meldrum, Dylan B Jackson, Robert Archer, Candice Ammons-Blanfort
OBJECTIVES: To examine whether perceptions of school safety and neighborhood safety are associated with insufficient sleep during adolescence. DESIGN: The Florida Youth Substance Abuse Survey (FYSAS) is a cross-sectional study of adolescents. SETTING: The state of Florida. PARTICIPANTS: Middle-school and high-school students (n = 7,958) attending public schools in 2017. MEASUREMENTS: Based on National Sleep Foundation recommendations, sleep was categorized as insufficient (less than 7 hours) or sufficient (7 or more hours) using self-reports of average sleep duration on school nights...
October 2018: Sleep Health
Doris Day, Cheryl M Burgess, Leon H Kircik
Melatonin is an endogenous hormone commonly associated with regulation of sleep. However, over the last two decades, research has elucidated a range of effects associated with the compound, including anti-inflammatory, both direct and indirect antioxidant activity, tissue regenerative benefits, and preservation of mitochondrial function. Melatonin's anti-inflammatory and antioxidant support, coupled with its mitochondrial support, make it an intriguing target for use to support skin health. Human skin and hair follicles express functional melatonin receptors...
September 1, 2018: Journal of Drugs in Dermatology: JDD
Gurpreet Kaur, Gaurav Prakash, Pankaj Malhotra, Sandhya Ghai, Sukhpal Kaur, Mahender Singh, Kulbeer Kaur
Background: Yoga is proven beneficial in improving quality of life among breast cancer survivors receiving chemotherapy, but its effectiveness in lymphoma patients needs to be explored. As chemotherapy-induced neutropenia is very common among lymphoma patients, they are much prone to infections from the environment. Furthermore, trained yoga instructors are not available in every setting, so there is a need to develop home-based yoga program modules for lymphoma patients receiving chemotherapy...
September 2018: International Journal of Yoga
Thomaz Fleury Curado, Arie Oliven, Luiz U Sennes, Vsevolod Y Polotsky, David Eisele, Alan R Schwartz
Over the past 30 years, hypoglossal nerve stimulation has moved through a development pathway to become a viable treatment modality for patients with obstructive sleep apnea. Initial pilot studies in animals and humans laid the conceptual foundation for this approach, leading to the development of fully implantable stimulating systems for therapeutic purposes. These devices were then demonstrated to be both safe and efficacious in feasibility studies. One such closed-loop stimulating device was found effective in treating a limited spectrum of apneic patients and is currently FDA-approved for this purpose...
September 14, 2018: Chest
Jennifer Joan Ryan, Douglas Allen Hanes, Jamie Corroon, Jan Taylor, Ryan D Bradley
OBJECTIVE: To prospectively examine the long-term safety of a cardiovascular health dietary supplement by assessing a comprehensive set of safety measures. DESIGN: Single-arm, open-label study. LOCATION: National University of Natural Medicine, Portland, OR. SUBJECTS: Thirty adults with screening blood pressure readings consistent with prehypertension or stage I hypertension. INTERVENTION: One caplet per day of a dietary supplement for 6 months...
September 14, 2018: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
Vivek Kumbhari, Ling Li, Klaus Piontek, Masaharu Ishida, Rongdang Fu, Bassem Khalil, Caroline M Garrett, Eleni Liapi, Anthony N Kalloo, Florin M Selaru
BACKGROUND AND AIMS: A simple, safe, targeted, and efficient in vivo DNA delivery system is necessary for clinical-grade liver-targeted gene therapy in humans. Intravascular hydrodynamic gene delivery has been investigated in large animal models, but translation to humans has been hampered by its technical challenges, invasiveness, and potential for significant cardiovascular adverse events. We posited that intrabiliary delivery of DNA plasmids via ERCP-guided hydrodynamic injection could overcome these obstacles...
October 2018: Gastrointestinal Endoscopy
Andrea Romigi, Giuseppe Vitrani, Temistocle Lo Giudice, Diego Centonze, Valentina Franco
Narcolepsy is a rare sleep disorder characterized by excessive daytime sleepiness and rapid eye movement sleep dysregulation, manifesting as cataplexy and sleep paralysis, as well as hypnagogic and hypnopompic hallucinations. Disease onset may occur at any age, although adolescents and young adults are mainly affected. Currently, the diagnosis delay ranges from 8 to 10 years and drug therapy may only attenuate symptoms. Pitolisant is a first-in-class new drug currently authorized by the European Medicines Agency to treat narcolepsy with or without cataplexy in adults and with an expanded evaluation for the treatment of neurologic diseases such as Parkinson's disease and epilepsy...
2018: Drug Design, Development and Therapy
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