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https://www.readbyqxmd.com/read/30515416/a-comparative-study-on-efficacy-and-safety-of-propofol-versus-dexmedetomidine-in-sleep-apnea-patients-undergoing-drug-induced-sleep-endoscopy-a-consort-prospective-randomized-controlled-clinical-trial
#1
L L Zhao, H Liu, Y Y Zhang, J Q Wei, Y Han, L Han, J P Yang
The aim of this study is to compare the efficacy and safety of propofol with dexmedetomidine in patients with obstructive sleep apnea hypopnea syndrome (SAHS) undergoing drug-induced sleep endoscopy (DISE). The 88 patients diagnosed with SAHS in the Affiliated Hospital of Xuzhou Medical University were randomly allocated into 2 groups (n = 44). Patients in the group dexmedetomidine (group D) received continuous intravenous infusion of dexmedetomidine 1 μ g/kg over 15 minutes before the endoscopy, and propofol 2 mg/kg was intravenously administrated in the group propofol (group P)...
2018: BioMed Research International
https://www.readbyqxmd.com/read/30514238/use-of-over-the-counter-products-in-older-cardiovascular-patients-admitted-to-a-tertiary-care-center-in-usa
#2
Marwan Sheikh-Taha, Hani Dimassi
BACKGROUND: In recent years there has been a substantial increase in the use of over-the-counter (OTC) products around the world. While they are assumed to be safe by consumers, they can potentially lead to adverse effects and drug interactions particularly in older adults. METHODS: We assessed the patterns of OTC products used by older adults admitted to the cardiology service in a tertiary care medical center in the USA over a three month period. We conducted a retrospective chart review where older adults with cardiovascular diseases (CVD) who were taking at least one OTC product at home were included...
December 4, 2018: BMC Geriatrics
https://www.readbyqxmd.com/read/30509211/-if-i-do-10-15-normal-deliveries-in-a-month-i-hardly-ever-sleep-at-home-a-qualitative-study-of-health-providers-reasons-for-high-rates-of-caesarean-deliveries-in-private-sector-maternity-care-in-delhi-india
#3
Alison Peel, Abhishek Bhartia, Neil Spicer, Meenakshi Gautham
BACKGROUND: Although the overall rate of caesarean deliveries in India remains low, rates are higher in private than in public facilities. In a household survey in Delhi, for instance, more than half of women delivering in private facilities reported a caesarean section. Evidence suggests that not all caesarean sections are clinically necessary and may even increase morbidity. We present providers' perspectives of the reasons behind the high rates of caesarean births in private facilities, and possible solutions to counter the trend...
December 3, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/30477064/efficacy-and-safety-of-levocloperastine-in-the-treatment-of-dry-cough-a-prospective-observational-study
#4
K Satish, Deepa Sholapuri, Vinit Niranjane, Sandeep Garg
Purpose/Aim: To evaluate effectiveness and safety of Levocloperastine in the treatment of dry cough in adult Indian patients. Methods: In this prospective, observational study, patients aged 18-60 years, presenting with dry cough and prescribed with Levocloperastine at baseline or a day prior to enrolment, as per standard clinical practice, were recruited from 3 centers in India. The scores of cough severity (100 mm VAS), cough frequency since last 24 h (7-point Likert scale), sleep disruption due to night-time awakenings (10 cm VAS), quality of life (QoL) (Leicester Cough Questionnaire [LCQ]), and number of days for achieving minimal important difference (MID) in cough severity (17 mm improvement on VAS) were assessed from baseline to Day 14...
May 2018: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/30473152/response-to-a-national-issue-moving-beyond-back-to-sleep-at-three-hospitals
#5
Martha Rider Sleutel, Barbara True, Heidi Gustus, Kathy Baldwin, Brandi Early
PURPOSE: To measure changes in registered nurse (RN) knowledge/beliefs and practices, parents' recall of infant safe sleep (ISS) teaching, and inpatient infant sleep environments and safety after implementing an ISS initiative. DESIGN AND METHODS: This longitudinal quasi-experimental study took place in three hospitals in the United States. An existing infant safe sleep tool was revised and updated to align with current recommendations on sleep environments. A bundled intervention included educating nurses, changing unit processes and implementing crib cards and room signs...
November 2018: Journal of Pediatric Nursing
https://www.readbyqxmd.com/read/30467707/revisional-roux-en-y-gastric-bypass-a-safe-surgical-opportunity-results-of-a-case-matched-study
#6
Antoine Vallois, Benjamin Menahem, Yannick Le Roux, Adrien Lee Bion, Hugo Meunier, Thomas Gautier, Nicolas Contival, Andrea Mulliri, Jean Lubrano, Jean-Jacques Parienti, A Alves
OBJECTIVE: To evaluate the safety and efficacy of revisional Roux-en-Y gastric bypass (RYGB) after adjustable gastric banding (AGB) or sleeve gastrectomy (SG) compared with primary RYGB, in regard to early and late morbidity, weight, and resolution of obesity-related comorbidities. METHODS: The group of patients undergoing revisional RYGB was matched in a 1:1 ratio with control patient who underwent a primary RYGB, based on age, gender, American Society of Anesthesiologist (ASA) score, preoperative body mass index (BMI), and diabetes mellitus...
November 22, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/30467472/herbal-medicine-formulas-for-parkinson-s-disease-a-systematic-review-and-meta-analysis-of-randomized-double-blind-placebo-controlled-clinical-trials
#7
Chun-Shuo Shan, Hong-Feng Zhang, Qing-Qing Xu, Yi-Hua Shi, Yong Wang, Yan Li, Yan Lin, Guo-Qing Zheng
Background: Parkinson's disease (PD) is a debitlitating, chronic, progressive neurodegenerative disorder without modifying therapy. Here, we aimed to evaluate the available evidence of herbal medicine (HM) formulas for patients with PD according to randomized double-blind placebo-controlled clinical trials. Methods: HM formulas for PD were searched in eight main databases from their inception to February 2018. The methodological quality was assessed using Cochrane Collaboration risk of bias tool. Meta-analysis was performed using RevMan 5...
2018: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/30467307/efficacy-and-safety-of-treatment-with-transcutaneous-vagus-nerve-stimulation-in-17-patients-with-refractory-epilepsy-evaluated-by-electroencephalogram-seizure-frequency-and-quality-of-life
#8
Aihua Liu, Peijing Rong, Li Gong, Lu Song, Xian Wang, Liping Li, Yuping Wang
BACKGROUND This study aimed to investigate the efficacy and safety of treatment with transcutaneous vagus nerve stimulation (tVNS) for patients with refractory epilepsy by evaluation of the frequency of seizures, electroencephalogram (EEG) changes, and quality of life on follow-up at three months and six months. MATERIAL AND METHODS EEG evaluation followed baseline evaluation with EEG at three months and six months following tVNS treatment. The frequency of seizures was recorded during the six-month study period...
November 23, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/30466131/-alginate-on-demand-as-add-on-for-patients-with-gastro-oesophageal-reflux-disease-and-insufficient-ppi-effect
#9
Matthias Müller, Gisela Labenz, Daniela-P Borkenstein, Joachim Labenz
BACKGROUND:  Chronic reflux patients with long-term PPI therapy frequently have persistent symptoms. A critical source of the persistent acid reflux is the acid pocket, which can be treated effectively by the non-systemic reflux suppressing action of alginates. METHODS:  GERD patients with at least one year of PPI long-term therapy, who were dissatisfied with their therapy, were treated over a period of 14 days with alginate as add-on and when required (up to 4 times daily) in a prospective, multi-centre, non-randomised, non-interventional and uncontrolled study in GP practices...
November 22, 2018: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/30461485/infant-safe-sleep-practices-in-the-united-states
#10
Jennifer M Bombard, Katherine Kortsmit, Carri Cottengim, Emily O Johnston
Risk of sleep-related infant deaths can be reduced by improving safe sleep practices.
December 2018: American Journal of Nursing
https://www.readbyqxmd.com/read/30454601/thermoregulation-and-the-ultradian-basic-rest-activity-cycle
#11
William W Blessing
Daily life involves interactions with the external environment. In rats these apparently spontaneous interactions, often associated with the search for food, alternate with periods of rest in both the dark and light periods of the 24-hour day. Kleitman, in whose laboratory rapid eye movement sleep was discovered, referred to the temporal pattern as "the basic rest-activity cycle." The active periods of the basic rest-activity cycle occur approximately every 1-2 hours in an irregular stochastic pattern that has been described (perhaps unhelpfully) as ultradian rhythmicity...
2018: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/30445937/the-impact-of-attending-day-care-designed-for-home-dwelling-people-with-dementia-on-nursing-home-admission-a-24-month-controlled-study
#12
Anne Marie Mork Rokstad, Knut Engedal, Øyvind Kirkevold, Jūratė Šaltytė Benth, Geir Selbæk
BACKGROUND: Day care services offer meaningful activities, a safe environment for attendees and respite for family caregivers while being expected to delay the need for nursing home (NH) admission. However, previous research has shown inconsistent results regarding postponement of NH admission. The objective of the study was to explore the influence of a day care programme designed for home-dwelling people with dementia on NH admission. METHOD: A quasi-experimental trial explored the proportion of patients permanently admitted to nursing homes after 24 months as the main outcome by comparing a group of day care attendees (DG) and a group of participants without day care (CG)...
November 16, 2018: BMC Health Services Research
https://www.readbyqxmd.com/read/30431712/a-cadaveric-model-for-measuring-sinonasal-continuous-positive-airway-pressure-a-proof-of-concept-study
#13
Ryan A Rimmer, Chandala Chitguppi, Hermes G Garcia, Ian J Koszewski, Gurston G Nyquist, Marc R Rosen, Colin Huntley, James J Evans, Mindy R Rabinowitz
BACKGROUND: Obstructive sleep apnea is a common respiratory disorder that can have negative effects on health and quality of life. Positive pressure therapy (CPAP) is the primary treatment. There is a lack of consensus on the risk of postoperative CPAP after endoscopic sinus or skull base surgery. We present a proof-of-concept cadaver model for measuring sinonasal pressure delivered by CPAP. METHODS: Three fresh cadaver heads were prepared by removing the calvaria and brain...
November 15, 2018: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/30430382/tailored-one-anastomosis-gastric-bypass-3-year-outcomes-of-94-patients
#14
Theodoropoulos Charalampos, Natoudi Maria, Vrakopoulou Gavriella Zoi Vrakopoulou, Triantafyllou Tania, Dimitrios Raptis, Zografos George, Leandros Emmanouil, Albanopoulos Konstantinos
BACKGROUND: One anastomosis gastric bypass (OAGB) claims its place among bariatric operations, proving itself a safe and effective procedure. METHODS: This is a retrospective analysis of prospectively collected data regarding 94 patients who underwent surgery in a single surgical unit. Tailoring of the biliopancreatic limb length decided upon preoperative BMI was applied. Patients' excess weight loss and resolution of comorbidities were evaluated. Data on patients' nutritional status is also presented...
November 14, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/30427651/endocrine-conditions-in-older-adults-anti-aging-therapies
#15
Sarah Bradford, Anita Ramsetty, Scott Bragg, Jennifer Bain
Interest in slowing or reversing the process of aging continues to grow and has encouraged the growth of an entire anti-aging industry. However, there is a dearth of data based on randomized trials in humans to support proposed therapies to address the various complex processes involved in aging. Hormonal therapies, in particular, have little data to support safe use and are associated with some degree of risk. Experimental data in animal models suggest possible molecular targets but their use in clinical medicine is far in the future...
November 2018: FP Essentials
https://www.readbyqxmd.com/read/30404691/-effectiveness-of-laparoscopic-sleeve-gastrectomy-in-treating-obesity-and-its-co-morbidities
#16
Zi Jian Li, Jian Chun Yu, Wei Ming Kang, Zhi Qiang Ma, Xin Ye, Hui Juan Zhu, Kang Yu, Wei Chen, Yan Ping Liu, Tao Li, Yi Xiao, Jin Mei Luo, Shu Yang Zhang
Objective To analyze the effectiveness and safety of laparoscopic sleeve gastrectomy (LSG) in treating obesity and its co-morbidities.Methods The clinical data of obese patients undergoing LSG in Peking Union Medical College Hospital from August 2012 to August 2017 were retrospectively analyzed. Medium-term outcome measures included excess weight loss (%EWL),co-morbidity improvement,and complications.Results Seventy-five obese patients comprising 28 men[ body mass index(BMI):(47.3±7.5)kg/m 2 ) ] and 47 women [BMI (41...
October 30, 2018: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://www.readbyqxmd.com/read/30402294/effects-of-bright-light-with-reduced-blue-light-on-sleepiness-on-rising-a-small-exploratory-study
#17
Jun Miura, Tomonori Yuasa, Yasunori Sugai, Kana Yamagami, Yoshihisa Aizu
Bright light therapy is a treatment modality for seasonal affective disorder and circadian rhythm disorders in which artificial light of 2,500 lux or higher at the eye is effective. Although short-wavelength visible light is more effective than long-wavelength visible light, it may be hazardous to the retina. Recently, light-emitting diodes (LEDs) have been used as the light source in bright light therapy apparatuses. We developed goggles for bright light therapy equipped with LEDs as the light source. The aim of this study was to examine the efficacy and safety of our goggles when emitting 10,000-lux light with its short-wavelength light content reduced by 30% or 50% (denoted as 30%-cut and 50%-cut light, respectively, henceforth)...
2018: Sleep Disorders
https://www.readbyqxmd.com/read/30400977/safety-and-efficacy-of-applying-sufficient-analgesia-combined-with-a-minimal-sedation-program-as-an-early-antihypertensive-treatment-for-spontaneous-intracerebral-hemorrhage-a-randomized-controlled-trial
#18
Rui Dong, Fen Li, Ying Xu, Pingyan Chen, Marc Maegele, Hong Yang, Wenjin Chen
BACKGROUND: Spontaneous intracerebral hemorrhage (ICH) is a serious threat to human health. Although early blood pressure (BP) elevation is closely associated with a poor prognosis, the optimal antihypertensive regimen for acute-phase ICH remains controversial. In ICH, pain, sleep deprivation, and stress are usually the main causes of dramatic BP increases. While traditional antihypertensive treatment resolves the increased BP, it does not address the root cause of the disease. Remifentanil relieves pain and, when combined with dexmedetomidine's antisympathetic action, can restore elevated BP to normal levels...
November 6, 2018: Trials
https://www.readbyqxmd.com/read/30388037/prospective-open-trial-of-adjunctive-triple-chronotherapy-for-the-acute-treatment-of-depression-in-adolescent-inpatients
#19
Diane Hurd, Mariela Herrera, Jeannine M Brant, Nicholas C Coombs, Eric Arzubi
OBJECTIVE: The aim of this pilot study was to explore the feasibility and proof of concept of triple chronotherapy (TCT) as a nonpharmacological adjunctive treatment in the acute management of depression in the adolescent population. METHODS: Thirty-one adolescents with nonpsychotic moderate-to-severe depression were included in the study. The 4-day TCT intervention comprised one night of sleep deprivation followed by 3 days of sleep phase advancement and daily bright light therapy...
November 2, 2018: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/30386488/impact-of-volume-and-type-of-overnight-pages-on-resident-sleep-during-home-call
#20
Adam E Ludvigson, Stephen T Ryan, Christina R Gentile, Gregory J Mills, Graham T VerLee, Moritz H Hansen
Background : Little research exists regarding factors that contribute to resident fatigue during home call. Objective : We objectively tracked the number and type of pages received, as well as residents' sleep time, during home call. We then examined the relationship between paging volume, resident sleep, and resident fatigue. Methods : A total of 4 of 4 urology residents (100%) at a single institution wore a FitBit Charge HR device from July 2015 to July 2016 to track sleep...
October 2018: Journal of Graduate Medical Education
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