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https://www.readbyqxmd.com/read/30341655/peroral-endoscopic-myotomy-leads-to-higher-rates-of-abnormal-esophageal-acid-exposure-than-laparoscopic-heller-myotomy-in-achalasia
#1
Madhusudhan R Sanaka, Prashanthi N Thota, Malav P Parikh, Umar Hayat, Niyati M Gupta, Scott Gabbard, Rocio Lopez, Sudish Murthy, Siva Raja
BACKGROUND AND AIMS: Peroral endoscopic myotomy (POEM) may be associated with higher rates of gastroesophageal reflux disease (GERD) than laparoscopic Heller's myotomy with fundoplication (LHM), since POEM is not combined with a fundoplication. However, peri-esophageal anti-reflux barriers are preserved in POEM, which might prevent GERD. Hence, we sought to compare the objective esophageal pH study findings in achalasia patients after POEM and LHM. METHODS: Achalasia patients undergoing POEM from 2014 to 2015 at our institution were matched 1:3 with LHM patients using propensity score matching...
October 19, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/30312588/the-prevalence-of-gastroesophageal-reflux-in-patients-with-excessive-central-airway-collapse
#2
Adnan Majid, Fayez Kheir, Daniel Alape, Michael Kent, Anthony Lembo, Vikram V Rangan, Megan Carreiro, Sidhu P Gangadharan
BACKGROUND: Gastroesophageal reflux (GER) is increasing recognized as an exacerbating or causal factor in several respiratory diseases. There is a high prevalence of GER in infants with airway malacia. However, such data is lacking in adults. METHODS: We conducted a retrospective study to determine the relationship between GER and excessive central airway collapse (ECAC). Consecutive patients with ECAC referred to the Complex Airway Center at Beth Israel Deaconess Medical Center who underwent esophageal pH testing for GER between July 2014 and June 2018 were included...
October 9, 2018: Chest
https://www.readbyqxmd.com/read/30232618/long-term-outcomes-following-poem-for-non-achalasia-motility-disorders-of-the-esophagus
#3
Filippo Filicori, Christy M Dunst, Ahmed Sharata, Walaa F Abdelmoaty, Ahmed M Zihni, Kevin M Reavis, Steven R Demeester, Lee L Swanström
BACKGROUND: Optimal treatment for symptomatic patients with non-achalasia motility disorders (NAD) such as diffuse esophageal spasm, esophagogastric junction outlet obstruction, and hypercontractile disorder is not well established. POEM has been offered to these patients since it is a less invasive and less morbid procedure but long-term outcomes remain undetermined. The aim of this study was to assess long-term outcomes of POEM for patients with NAD. METHODS: Records of 40 consecutive patients undergoing POEM for NAD from May 2011 to January 2016 at a single center were retrospectively reviewed...
September 19, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/30100404/laparoscopic-anti-reflux-surgery-for-the-treatment-of-idiopathic-pulmonary-fibrosis-wrap-ipf-a-multicentre-randomised-controlled-phase-2-trial
#4
Ganesh Raghu, Carlos A Pellegrini, Eric Yow, Kevin R Flaherty, Keith Meyer, Imre Noth, Mary Beth Scholand, John Cello, Lawrence A Ho, Sudhakar Pipavath, Joyce S Lee, Jules Lin, James Maloney, Fernando J Martinez, Ellen Morrow, Marco G Patti, Stan Rogers, Paul J Wolters, Robert Yates, Kevin J Anstrom, Harold R Collard
BACKGROUND: Abnormal acid gastro-oesophageal reflux (GER) is hypothesised to play a role in progression of idiopathic pulmonary fibrosis (IPF). We aimed to determine whether treatment of abnormal acid GER with laparoscopic anti-reflux surgery reduces the rate of disease progression. METHODS: The WRAP-IPF trial was a randomised controlled trial of laparoscopic anti-reflux surgery in patients with IPF and abnormal acid GER recruited from six academic centres in the USA...
September 2018: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/30097162/characterisation-of-laryngo-pharyngeal-reflux-disease-in-old-and-ageing-patients
#5
Francisco J Cervera-Paz, Marta Jordano-Cabrera
OBJECTIVES: To characterize laryngo-pharyngeal reflux (LPR) in patients over 60 years of age. METHODS: Retrospective review of patients over 60 years of age with symptoms suspicious of LPR, seen from 2005 to 2014 at an ENT Department of an academic hospital. Eighty-five consecutive patients (54 females, 31 males) who had completed a dual-sensor 24-hour pH-metry were included (considered "gold-standard" in LPR diagnosis). Body mass index, and reflux information and interventions were revised...
August 7, 2018: Acta Otorrinolaringológica Española
https://www.readbyqxmd.com/read/30046950/regression-of-intestinal-metaplasia-following-magnetic-sphincter-augmentation-device-placement
#6
Evan T Alicuben, James M Tatum, Nikolai Bildzukewicz, Kamran Samakar, Jamil S Samaan, Einav N Silverstein, Kulmeet Sandhu, Caitlin C Houghton, John C Lipham
BACKGROUND: Intestinal metaplasia represents an esophageal mucosal transformation due to uncontrolled gastroesophageal reflux disease. Fundoplication has been shown to lead to regression of disease. Magnetic sphincter augmentation is an alternative to fundoplication that effectively treats reflux disease. Initially, patients with intestinal metaplasia were not considered candidates for device placement, so outcomes in these patients are unknown. METHODS: A retrospective review of all patients who underwent magnetic sphincter augmentation device placement between 2007 and 2017 was performed...
July 25, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29996188/-correlation-between-severity-of-gastroesophageal-reflux-cough-and-degree-of-gastroesophageal-reflux-disease
#7
S P Tang, Y L Liu, H Gao, L Dong, D R Lin, S Chen, D Y Zhang, L L Zhang, J Pan
Objective: To explore the correlation between the severity of gastroesophageal reflux cough and degree of gastroesophageal reflux. Methods: A cross-sectional investigation was carried out. Data of 174 cases of chronic cough were collected in Children's Hospital of Fuzhou from March 2009 to December 2016. The esophageal 24 hours pH value dynamic monitoring was used to detect gastric acid reflux index. Cases with abnomal results were divided into mild, moderate and severe groups according to severity of reflux and that of day and night cough symptoms, respectively...
July 2, 2018: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/29992917/comparison-of-esophageal-function-tests-to-investigate-the-effect-of-helicobacter-pylori-infection-on-gastroesophageal-reflux-disease-gerd
#8
Lan Liu, Hongwei Gao, Hongjuan Wang, Weihua Yu, Kongxi Zhu, Yuan Zhang, Jianqiang Guo
BACKGROUND The effects of Helicobacter pylori (H. pylori) infection on gastroesophageal reflux disease (GERD) remain unclear. The aim of this study was to compare the results of clinical esophageal function tests and the effect of H. pylori infection on GERD. MATERIAL AND METHODS A prospective clinical study included 124 patients diagnosed with GERD (four grades). H. pylori infection was determined by gastroscopy and a rapid urease test (RUT) to divide patients into an HP-positive and an HP-negative group. Esophageal function tests included high-resolution manometry (HRM), peristalsis break (PB), and 24-hour pH monitoring (composite pH DeMeester score)...
July 11, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29974879/a-prospective-study-of-gastro-oesophageal-reflux-disease-symptoms-and-quality-of-life-1-year-post-laparoscopic-sleeve-gastrectomy
#9
Andrew G N Robertson, Andrew J Cameron, Brian Joyce, Phil Le Page, Bruce Tulloh, Andrew C de Beaux, Peter J Lamb
Introduction: There are concerns that laparoscopic sleeve gastrectomy (LSG) can cause severe gastro-oesophageal reflux disease (GORD). The aim of this study was to assess GORD symptoms and quality of life following LSG. Methods: A prospective study of patients undergoing LSG (2014-2016) was performed with follow-up by DeMeester Reflux/Regurgitation Score, Bariatric Quality of Life Index (BQLI) and Bariatric Analysis and Reporting Outcome System (BAROS) Score pre-operatively, 6 months and 1-year post-operatively...
June 27, 2018: Journal of Minimal Access Surgery
https://www.readbyqxmd.com/read/29923009/specific-features-of-gastroesophageal-reflux-disease-in-patients-with-overweight-basis-for-personalized-treatment
#10
S I Kseneva, E V Borodulina, N E Selivanova, I V Mareev, V V Udut
А cross-sectional study was performed on a continuous sample of patients (N=52) with the gastroesophageal reflux disease. Specific features of this disease in patients with overweight were revealed. Regurgitation predominated in the structure of complaints. Fibrogastroduodenoscopy revealed endoscopically negative form of the diseases in 38% of cases. According to 24-h pH monitoring results, alkaline reflux pH>7 took more than 25% time in supine position at high DeMeester score, which limits the usage of aggressive acid-lowering therapy...
June 2018: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/29915812/the-esophageal-manometry-with-gas-perfused-catheters
#11
Sven Höhne, Martin Arndt, Viola Hesse
Background: The well-established methods for esophageal manometry have some disadvantages: the-water-perfused catheters needs calibration by gravity and measuring in supine position, and the solid-state catheters are very expensive. Manometry using gas-perfused catheters is a suitable alternative. There have been only a few publications about this. Objectives and methods: The results for esophageal manometry in 1700 patients were retrospectively analyzed based on the clinical reports and the manometry data...
2018: Open Medicine (Warsaw, Poland)
https://www.readbyqxmd.com/read/29905881/initial-experience-of-endoscopic-radiofrequency-waves-delivery-to-the-lower-esophageal-sphincter-stretta-procedure-on-symptomatic-gastroesophageal-reflux-disease-post-sleeve-gastrectomy
#12
Nesreen Khidir, Luigi Angrisani, Jowhara Al-Qahtani, Sheraz Abayazeed, Moataz Bashah
BACKGROUND: Gastroesophageal reflux disease (GERD) occurs de novo or intensifies after sleeve gastrectomy (LSG). Endoscopic radiofrequency (Stretta) is a minimally invasive, effective tool to treat GERD. However, Stretta safety and efficacy are unknown in patients with GERD after LSG. To evaluate the safety and efficacy of Stretta treatment post-LSG GERD, quality of life, and PPI dose up to 6 months. METHODS: A retrospective review of all patients' data who underwent Stretta procedure in our center...
October 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29886654/-analysis-of-clinical-data-esophageal-motility-and-reflux-characteristics-in-patients-with-non-erosive-reflux-disease-nerd-and-reflux-esophagitis-re
#13
H F Wang, F Liu, M Wang, S Y Du, Y L Zhang
Objective: To compare the clinical data, esophageal motility and reflux characteristic in patients with non-erosive reflux disease (NERD) and reflux esophagitis (RE). Methods: A total of 167 patients of NERD were enrolled in the study[60 males, 107 females, mean age(44.1±13.4) years old], and 151 patients of RE were enrolled [74 males, 77 females, mean age(46.5±9.9) years old]. All patients were surveyed by questionnaires to investigate the clinical data. All patients accepted the esophageal highresolution manometry and 24 hours pH+ impedance monitoring to investigate the esophageal motility and reflux characteristic...
May 29, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29846541/lower-prevalence-of-gastroesophageal-reflux-disease-in-patients-with-noncardiac-chest-pain-on-opiates-a-cross-sectional-study
#14
J D G Cifuentes, P N Thota, R Lopez
Opiates can cause heartburn and spastic esophageal dysmotility but their role in noncardiac chest pain (NCCP) is not known. Our aim was to characterize opiate effects on esophageal function using esophageal pH monitoring and high-resolution manometry (HREM) in these patients.We performed a cross sectional study of opiate users with NCCP who underwent HREM and esophageal pH study from 2010 to 2017 using opiate nonusers as a comparison group. Demographic data, symptoms, opiate use, endoscopic findings, esophageal pH study parameters, and HREM data were abstracted...
May 26, 2018: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/29625507/efficacy-of-transoral-incisionless-fundoplication-for-refractory-gastroesophageal-reflux-disease-a-systematic-review-and-meta-analysis
#15
Thomas R McCarty, Michael Itidiare, Basile Njei, Tarun Rustagi
BACKGROUND:  Given poor symptomatic response rates and rising awareness of the adverse events associated with the long-term use of proton pump inhibitors (PPIs), endoscopic modalities for treatment of refractory gastroesophageal reflux disease (GERD) have become more prominent. The aim of this study was to perform a systematic review and meta-analysis to evaluate feasibility, efficacy, and tolerability of transoral incisionless fundoplication (TIF) for the treatment of refractory GERD...
July 2018: Endoscopy
https://www.readbyqxmd.com/read/29617746/thoracoabdominal-pressure-gradient-and-gastroesophageal-reflux-insights-from-lung-transplant-candidates
#16
T Masuda, S K Mittal, B Kovacs, M Smith, R Walia, J Huang, R M Bremner
Advanced lung disease is associated with gastroesophageal reflux disease (GERD). The thoracoabdominal pressure gradient (TAPG) facilitates gastroesophageal reflux, but the effects of TAPG on gastroesophageal reflux in patients with pulmonary disease have not been well defined. Patients diagnosed with end-stage lung disease are expected to have the most extreme derangement in respiratory mechanics. The aim of this study is to explore the relationship between TAPG and reflux in lung transplant (LTx) candidates...
March 31, 2018: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/29602998/clinical-feasibility-of-a-new-full-thickness-endoscopic-plication-device-gerdx%C3%A2-for-patients-with-gerd-results-of-a-prospective-trial
#17
Michael Weitzendorfer, Georg O Spaun, Stavros A Antoniou, Kai Witzel, Klaus Emmanuel, Oliver O Koch
BACKGROUND: Previous studies suggest clinical effectiveness of endoscopic full-thickness plication in selected patients with gastroesophageal reflux disease (GERD). The aim of this study was to assess the clinical safety and efficiency of the GERDx™ device by evaluating clinical parameters, reflux symptom scores, and quality of life (QoL). METHODS: Prospective one-arm trial evaluating the outcome of forty patients with GERD subjected to endoscopic plication with the GERDx™ device...
May 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29572022/early-fundoplication-is-associated-with-slower-decline-in-lung-function-after-lung-transplantation-in-patients-with-gastroesophageal-reflux-disease
#18
Sreeja Biswas Roy, Shaimaa Elnahas, Rosemarie Serrone, Cassandra Haworth, Michael T Olson, Paul Kang, Michael A Smith, Ross M Bremner, Jasmine L Huang
OBJECTIVES: Gastroesophageal reflux disease (GERD) is prevalent after lung transplantation. Fundoplication slows lung function decline in patients with GERD, but the optimal timing of fundoplication is unknown. METHODS: We retrospectively reviewed patients who underwent fundoplication after lung transplantion at our center from April 2007 to July 2014. Patients were divided into 2 groups: early fundoplication (<6 months after lung transplantation) and late fundoplication (≥6 months after lung transplantation)...
June 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29534167/simultaneous-laryngopharyngeal-ph-monitoring-restech-and-conventional-esophageal-ph-monitoring-correlation-using-a-large-patient-cohort-of-more-than-100-patients-with-suspected-gastroesophageal-reflux-disease
#19
H F Fuchs, D T Müller, F Berlth, M K Maus, C Fuchs, M Dübbers, W Schröder, C J Bruns, J M Leers
24-hour esophageal pH-metry is not designed to detect laryngopharyngeal reflux (LPR). The new laryngopharyngeal pH-monitoring system (Restech) may detect LPR better. There is no established correlation between these two techniques as only small case series exist. The aim of this study is to examine the correlation between the two techniques with a large patient cohort. All patients received a complete diagnostic workup for gastroesophageal reflux including symptom evaluation, endoscopy, 24-hour pH-metry, high resolution manometry, and Restech...
March 8, 2018: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/29531596/dynamic-mri-evaluation-of-the-gastric-fundus-and-splenic-circulation-to-assess-the-gastric-breves-dissection-during-laparoscopic-nissen-fundoplication
#20
Gökhan Akkurt, Önder Sürgit, Hakan Ataş, Mustafa Alimoğullari
AIM: We aimed to evaluate the possible effects of dissecting gastric breves (GB) during the Laparoscopic Nissen Fundoplication (LNF) on the gastric fundus and splenic circulation using dynamic Magnetic Resonance Imaging (MRI). METHODS: In total 14 patients with gastroesophageal reflux disease (GERD) that was diagnosed with esophagogastroduodenoscopy and 24 - hour PH monitorization and undergoing LNF surgery were included. All patients underwent LNF surgery between October 2006 and March 2010...
February 15, 2018: Open Access Macedonian Journal of Medical Sciences
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