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https://www.readbyqxmd.com/read/30105738/in-situ-gel-forming-system-for-dual-bmp-2-and-17%C3%AE-estradiol-controlled-release-for-bone-regeneration-in-osteoporotic-rats
#1
Elisabet Segredo-Morales, Ricardo Reyes, María Rosa Arnau, Araceli Delgado, Carmen Évora
The aim of this study was to evaluate the bone regeneration capacity of a Pluronic® F127 (P)-Tetronic®1307 (T) and α-cyclodextrin (CD) supramolecular gel (P-T-CD) in a 11/7/7 ratio containing BMP-2 and 17β-estradiol pre-encapsulated in poly-lactide-co-glycolide (PLGA) and poly-lactic acid (PLA-S) microspheres, respectively. Ovariectomy combined with dexamethasone treatment was used to induce an osteoporotic (OP) animal model of calvaria critical size defect in female rats to test the system. The two active substances showed a biphasic in vitro release profile characterized by an initial fast phase followed by a slow and prolonged release...
August 13, 2018: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/30089587/eortc-qlq-c30-summary-score-reliably-detects-changes-in-qol-three-months-after-anatomic-lung-resection-for-non-small-cell-lung-cancer-nsclc
#2
Cecilia Pompili, Michael Koller, Galina Velikova, Kevin Franks, Kate Absolom, Matthew Callister, Jonathan Robson, Andrea Imperatori, Alessandro Brunelli
INTRODUCTION: We tested the European Organization for Research and Treatment of Cancer Quality of Life (EORTC QLQ-C30) summary score (SumSC) to detect changes in the HRQOL after Non-small-cell lung cancer (NSCLC) surgery and compared its performance to the traditional scales. METHOD: EORTC QLQ-C30 data was obtained from 326 consecutive pre-operative patients submitted for anatomical lung resections for NSCLC.66 patients completed post-operative assessments 3 months after surgery...
September 2018: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/30062524/observed-changes-in-brown-white-hepatic-and-pancreatic-fat-after-bariatric-surgery-evaluation-with-mri
#3
Steve C N Hui, Simon K H Wong, Qiyong Ai, David K W Yeung, Enders K W Ng, Winnie C W Chu
OBJECTIVES: To study the change in brown and white adipose tissue (BAT and WAT), as well as fat content in the liver and pancreas, in patients with morbid obesity before and after bariatric surgery. METHODS: Twelve patients with morbid obesity (F=8, M=4, age: 45.4 years (38.4-51.2), BMI: 35.2 kg/m2 (32.5-38.6)) underwent pre-op MRI at baseline and two post-op scans at 6-month and 12-month intervals after bariatric surgery. Co-registered water, fat, fat-fraction and T2* image series were acquired...
July 30, 2018: European Radiology
https://www.readbyqxmd.com/read/30060788/combined-intravitreal-triamcenolone-acetonide-and-bevacizumab-for-refractory-diabetic-macular-edema
#4
Muhammad Aamir Arain, Waqar Muzaffar, Omer Farooq, Muhammad Naeem Azhar
OBJECTIVE: To evaluate the effectiveness of combined Intravitreal triamcinolone acetonide (IVTA) and Intravitreal Bevacizumab (IVB) for treatment of refractory diabetic macular edema. STUDY DESIGN: Quasi-experimental study. PLACE AND DURATION OF STUDY: Armed Forces Institute of Ophthalmology (AFIO), Rawalpindi, from January to December 2017. METHODOLOGY: Pseudophakic diabetic patients with macular edema refractory to prior treatment were included...
August 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/30045343/opioid-utilization-following-lumbar-arthrodesis-trends-and-factors-associated-with-long-term-use
#5
Piyush Kalakoti, Nathan R Hendrickson, Nicholas A Bedard, Andrew J Pugely
STUDY DESIGN: A retrospective, observational cohort study. OBJECTIVE: In patients undergoing lumbar spine arthrodesis, we sought to establish perioperative trends in chronic versus naive opioid users (OUs) and identify modifiable risk factors associated with prolonged consumption. SUMMARY OF BACKGROUND DATA: The morbidity associated with excessive opioid use for chronic conditions continues to climb and has been identified as a national epidemic...
September 1, 2018: Spine
https://www.readbyqxmd.com/read/30035265/post-tonsillectomy-taste-dysfunction-myth-or-reality
#6
REVIEW
Liuba Soldatova, Richard L Doty
Lingual branches of the glossopharyngeal nerve (CN Ⅸ) are at risk of injury during tonsillectomy due to their proximity to the muscle layer of the palatine tonsillar bed. However, it is unclear how often this common surgery leads to taste disturbances. We conducted a literature search using PubMed, Embase, Cochrane Library, Google Scholar, PsychInfo, and Ovid Medline to evaluate the available literature on post-tonsillectomy taste disorders. Studies denoting self-reported dysfunction, as well as those employing quantitative testing, i...
March 2018: World Journal of Otorhinolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/30007267/link-between-estrogen-deficiency-osteoporosis-and-susceptibility-to-bone-metastases-a-way-towards-precision-medicine-in-cancer-patients
#7
REVIEW
F Salamanna, V Borsari, D Contartese, N Nicoli Aldini, M Fini
Different fields of cancer management consider bone health to be of increasing clinical importance for patients: 1) presence of bone metastases in many solid tumors, 2) use of bone-targeted treatments in the reduction of bone metastasis, 3) effects of cancer treatment on reproductive hormones, critical for normal bone remodeling maintenance. Additionally, bone microenvironment is further complicated by the decline of ovarian sex steroid production and by the related increase in inflammatory factors linked to menopause, which result in accelerated bone loss and increased risk of osteoporosis (OP)...
June 22, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29997897/delayed-cord-clamping-during-elective-cesarean-deliveries-results-of-a-pilot-safety-trial
#8
Caroline J Chantry, Aubrey Blanton, Véronique Taché, Laurel Finta, Daniel Tancredi
Background: Delayed cord clamping (DCC) results in decreased iron deficiency in infancy. The American College of Obstetrics and Gynecology has called for research on the optimal time to clamp the cord during cesarean deliveries (CD). Our objective was to conduct a pilot trial examining the safety of delayed cord clamping (DCC) for maternal-infant dyads during elective cesarean delivery (CD). Methods: We enrolled 39 dyads [23 at 90 s, 16 at 120 s; (DCC Pilot)] between 10/2013 and 9/2014...
2018: Maternal Health, Neonatology and Perinatology
https://www.readbyqxmd.com/read/29989926/learning-based-segmentation-of-ct-brain-images-application-to-postoperative-hydrocephalic-scans
#9
Venkateswararao Cherukuri, Peter Ssenyonga, Benjamin C Warf, Abhaya V Kulkarni, Vishal Monga, Steven J Schiff
OBJECTIVE: Hydrocephalus is a medical condition in which there is an abnormal accumulation of cerebrospinal fluid (CSF) in the brain. Segmentation of brain imagery into brain tissue and CSF [before and after surgery, i.e., preoperative (pre-op) versus postoperative (post-op)] plays a crucial role in evaluating surgical treatment. Segmentation of pre-op images is often a relatively straightforward problem and has been well researched. However, segmenting post-op computational tomographic (CT) scans becomes more challenging due to distorted anatomy and subdural hematoma collections pressing on the brain...
August 2018: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/29987980/mr-imaging-and-ct-features-of-oncocytic-papilloma-of-the-sinonasal-tract-with-comparison-to-inverted-papilloma
#10
Bentao Yang, Jing Li, Jiyong Dong
OBJECTIVE: To evaluate and compare the imaging feature of sinonasal oncocytic papilloma (OP) with inverted papilloma (IP). METHODS: The CT and MR imaging manifestations of 17 pathology proven sinonasal OPs were reviewed and compared with seventeen IPs randomly selected as a control group over the same period. RESULTS: Seventeen sinonasal OPs had unilateral occurrence and 16 of them (94.1%) had a lobulated configuration.The distribution of original sites differed significantly between OPs and IPs(P< 0...
July 10, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29951319/closed-reduction-in-a-hyperextended-supine-position-with-percutaneous-transsacral-transiliac-and-iliosacral-screw-fixation-for-denis-zone-iii-sacral-fractures
#11
Hideto Irifune, Suguru Hirayama, Nobuyuki Takahashi, Mitsumasa Chiba, Toshihiko Yamashita
Background: Herein, we demonstrate the clinical results of closed reduction in a hyperextended supine position with transsacral-transiliac (TSTI) and iliosacral (IS) screw fixations for Denis zone III sacral fractures. Patients and Methods: Sixteen consecutive patients with Denis zone III sacral fractures who were treated between January 2009 and September 2016 were evaluated. All patients were treated using percutaneous TSTI/IS screw fixation during closed reduction performed with patients placed in a hyperextended supine position with body manipulation...
2018: Advances in Orthopedics
https://www.readbyqxmd.com/read/29937939/technical-feasibility-of-tissue-microarray-tma-analysis-of-tumor-associated-immune-response-in-prostate-cancer
#12
Timothy J Wallace, Junqi Qian, Itzhak Avital, Curt Bay, Yan-Gao Man, Laurie L Wellman, Chris Moskaluk, Dean Troyer, Dharam Ramnani, Alexander Stojadinovic
Introduction : The androgen receptor (AR) regulates immune-related epithelial-to-mesenchymal transition (EMT), and prostate cancer (PCa) metastasis. Primary tumor-infiltrating lymphocytes (TILs) [CD3+ , CD4+ , and CD8+ TILs] are potential prognostic indicators in PCa, and variations may contribute to racial disparities in tumor biology and PCa outcomes. Aim : To assess the technical feasibility of tumor microarray (TMA)-based methods to perform multi-marker TIL profiling in primary resected PCa. Methods : Paraffin-embedded tissue cores of histopathologically-confirmed primary PCa ( n = 40; 1 TMA tissue specimen loss) were arrayed in triplicate on TMAs...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29913175/implementation-of-an-urogynecology-specific-enhanced-recovery-after-surgery-eras-pathway
#13
Charelle M Carter-Brooks, Angela L Du, Kristine M Ruppert, Anna L Romanova, Halina M Zyczynski
OBJECTIVES: ERAS protocols were developed for colorectal surgery to hasten post-op recovery. Variations of the protocol are being adopted for gynecologic procedures despite limited population and procedure-specific outcome data. Our objective was to evaluate if implementation of an ERAS pathway would facilitate reduced length of admission in an urogynecology population. MATERIALS AND METHODS: In this retrospective analysis of patients undergoing pelvic floor reconstructive surgery by 7 female pelvic medicine and reconstructive surgeons we compared same day discharge, length of admission and post-op complications before and after implementation of an ERAS pathway at a tertiary-care hospital...
June 15, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29909510/impact-on-dyslipidemia-after-laparoscopic-sleeve-gastrectomy
#14
Agustina Vigilante, Franco Signorini, Marcos Marani, Virginia Paganini, Germán Viscido, Luciano Navarro, Lucio Obeide, Federico Moser
BACKGROUND: Improvement of dyslipidemia is an important benefit of bariatric surgery. The benefits of laparoscopic sleeve gastrectomy (LSG) among dyslipidemia are still a matter of debate. METHODS: We conducted a retrospective descriptive study between 2010 and 2013. Obese patients undergoing LSG, with recorded dyslipidemia at admission and a follow-up for at least 1 year, were included for analysis. Demographic characteristics, medication in use, and a complete lipid profile were collected before surgery...
June 16, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29909229/functional-evaluation-of-bilateral-subtalar-arthroereisis-for-the-correction-of-flexible-flatfoot-in-children-1-year-follow-up
#15
Paolo Caravaggi, Giada Lullini, Lisa Berti, Sandro Giannini, Alberto Leardini
BACKGROUND: Flexible flatfoot (FFF) is a common alteration of the foot diagnosed in the pediatric population causing pain and decreased quality of life. Surgical treatment via arthroereisis of the subtalar joint can be recommended when non-invasive options do not result in sufficient pain relief. While clinical outcome of subtalar joint arthroereisis is generally positive, no functional evaluation has thus far been reported following surgery. RESEARCH QUESTION: The aim of this study was to assess the effects of two arthroereisis implants for the correction of bilateral FFF on foot and lower limb biomechanics during gait...
July 2018: Gait & Posture
https://www.readbyqxmd.com/read/29872643/three-dimensional-map-of-isoprognostic-zones-in-glottic-cancer-treated-by-transoral-laser-microsurgery-as-a-unimodal-treatment-strategy
#16
Cesare Piazza, Marta Filauro, Alberto Paderno, Filippo Marchi, Pietro Perotti, Riccardo Morello, Stefano Taboni, Giampiero Parrinello, Fabiola Incandela, Andrea Iandelli, Francesco Missale, Giorgio Peretti
Introduction: The Union for International Cancer Control-American Joint Committee on Cancer TNM staging system for glottic squamous cell carcinoma (SCC) includes different types of lesions defined by the involvement of specific subsites in each T category. Our study aims to identify different subcategories according to tumor local extension and determine oncologic outcomes after treatment by transoral laser microsurgery (TLM) alone. Methods: We retrospectively evaluated 410 patients affected by previously untreated pT1-pT3 glottic SCC treated by TLM alone from January 2005 to December 2015 at the Departments of Otorhinolaryngology-Head and Neck Surgery, Universities of Genoa and Brescia, Italy...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29808374/ficus-deltoidea-prevented-bone-loss-in-preclinical-osteoporosis-osteoarthritis-model-by-suppressing-inflammation
#17
Nur Adeelah Che Ahmad Tantowi, Seng Fong Lau, Suhaila Mohamed
Osteoporosis (OP) and osteoarthritis (OA) are debilitating musculoskeletal diseases of the elderly. Ficus deltoidea (FD) or mistletoe fig, a medicinal plant, was pre-clinically evaluated against OP- and OA-related bone alterations, in postmenopausal OA rat model. Thirty twelfth-week-old female rats were divided into groups (n = 6). Four groups were bilateral ovariectomized (OVX) and OA-induced by intra-articular monosodium iodoacetate (MIA) injection into the right knee joints. The Sham control and OVX-OA non-treated groups were given deionized water...
May 28, 2018: Calcified Tissue International
https://www.readbyqxmd.com/read/29777672/valvectomy-versus-replacement-for-the-surgical-treatment-of-tricuspid-endocarditis
#18
Adam N Protos, Jaimin R Trivedi, William M Whited, Michael P Rogers, Ugochukwu Owolabi, Kendra J Grubb, Kristen Sell-Dottin, Mark S Slaughter
BACKGROUND: Optimal surgical treatment of infective tricuspid endocarditis is debatable, especially in the setting of inherent social and pathologic concerns. This study seeks to compare tricuspid valve repair, replacement, and excision for the treatment of infective endocarditis METHODS: A single center cardiac surgery database was queried between 2012 and 2016 to identify patients >18 years who underwent tricuspid valve surgery for infective endocarditis. Patients were divided into 3 groups based on the type of tricuspid valve surgery: valvectomy, repair, or replacement and evaluated to identify differences between the pre-op factors and outcomes including mortality, length of stay, and complications...
May 16, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29774412/hybrid-constructs-pedicle-screw-with-apical-sublaminar-bands-versus-pedicle-screws-only-for-surgical-correction-of-adolescent-idiopathic-scoliosis
#19
Matteo Palmisani, Eugenio Dema, Stefano Cervellati, Rosa Palmisani
PURPOSE: To compare the 2-year minimum postoperative results of posterior correction and spinal arthrodesis using translational correction with hybrid (sublaminar bands on concave side and pedicle screw) constructs versus correction with intermediate density pedicle screw-only constructs in the treatment of AIS (Lenke 1). METHODS: A total of 37 patients with AIS at single institutions who underwent posterior spinal arthrodesis pedicle screw with sublaminar bands at the apex (19 patients) (Group A) or pedicle screw-only (18) constructs (Group B) were selected and matched according to similar age at surgery 13...
June 2018: European Spine Journal
https://www.readbyqxmd.com/read/29761422/computational-pre-surgical-planning-of-arterial-patch-reconstruction-parametric-limits-and-in-vitro-validation
#20
S Samaneh Lashkarinia, Senol Piskin, Tijen A Bozkaya, Ece Salihoglu, Can Yerebakan, Kerem Pekkan
Surgical treatment of congenital heart disease (CHD) involves complex vascular reconstructions utilizing artificial and native surgical materials. A successful surgical reconstruction achieves an optimal hemodynamic profile through the graft in spite of the complex post-operative vessel growth pattern and the altered pressure loading. This paper proposes a new in silico patient-specific pre-surgical planning framework for patch reconstruction and investigates its computational feasibility. The proposed protocol is applied to the patch repair of main pulmonary artery (MPA) stenosis in the Tetralogy of Fallot CHD template...
May 14, 2018: Annals of Biomedical Engineering
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