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https://www.readbyqxmd.com/read/30288691/surgical-management-of-gastroesophageal-reflux-disease-in-patients-with-severe-esophageal-dysmotility
#1
Priscila R Armijo, Dietric Hennings, Melissa Leon, Akshay Pratap, Austin Wheeler, Dmitry Oleynikov
BACKGROUND: Gastroesophageal reflux disease (GERD) and esophageal dysmotility are often disqualifying criteria for fundoplication due to dysphagia complications. A tailored partial fundoplication may improve GERD in patients with severe esophageal motility disorders. We evaluate this approach on GERD improvement in non-achalasia esophageal dysmotility patients. METHODS: A single-institution prospective database was reviewed (2007-2016), with inclusion criteria of GERD, previous diagnosis of non-achalasia esophageal motility disorder, and laparoscopic partial fundoplication...
October 4, 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/30269170/modern-tka-implants-are-equivalent-to-traditional-tka-implants-in-functional-and-patellofemoral-joint-related-outcomes
#2
Jia Long Chua, Graham Seow-Hng Goh, Ming Han Lincoln Liow, Darren Keng-Jin Tay, Ngai-Nung Lo, Seng-Jin Yeo
PURPOSE: To compare patient-reported outcomes measures, health-related quality of life and satisfaction rates between a new Modern TKA system (M-TKA) and an existing Traditional TKA system (T-TKA). METHODS: Prospectively collected registry data of 65 patients who underwent T-TKA and 65 patients who underwent M-TKA at a single institution from 2014 to 2015 was reviewed. The range of motion, Knee Society Knee Score (KSKS), Function Score (KSFS), Oxford Knee Score (OKS), SF-36, satisfaction and expectation fulfilment were compared at Pre-op, 6 months and 2 years...
September 29, 2018: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/30261330/longitudinal-evaluation-of-quality-of-life-in-laryngeal-cancer-patients-treated-with-surgery
#3
Anh The Bui, Keven Seung Yong Ji, Canh Tuan Pham, Ky Minh Le, Thang Xuan Tong, Walter Tsong Lee
BACKGROUND: There is insufficient prospective data on quality of life outcomes for laryngeal cancer patients undergoing surgery, especially in low- and middle-income countries. This limits clinical and patient decision-making, and survivorship expectations. This research aimed to define longitudinal changes in quality of life in patients with laryngeal cancer from the pre-operative to post-operative period. MATERIALS AND METHODS: A prospective cohort with primary laryngeal cancer treated with standard-of-care surgery who have completed a minimum follow-up of 1 year were evaluated...
October 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/30220556/benefits-and-risks-of-unilateral-and-bilateral-ventral-intermediate-nucleus-deep-brain-stimulation-for-axial-essential-tremor-symptoms
#4
Kyle T Mitchell, Paul Larson, Philip A Starr, Michael S Okun, Robert E Wharen, Ryan J Uitti, Barton L Guthrie, DeLea Peichel, Rajesh Pahwa, Harrison C Walker, Kelly Foote, Frederick J Marshall, Joseph Jankovic, Richard Simpson, Fenna Phibbs, Joseph S Neimat, R Malcolm Stewart, Khashayar Dashtipour, Jill L Ostrem
INTRODUCTION: Many experts assume bilateral deep brain stimulation (DBS) is necessary to improve axial tremor in essential tremor (ET). In the largest clinical trial of DBS for ET to date evaluating a non-directional, constant current device, we studied the effects of unilateral and staged bilateral DBS on axial tremor. METHODS: We included all participants from the original trial with unilateral ventral intermediate nucleus (VIM) DBS and 90-day follow up at minimum...
September 6, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/30218251/optimal-surgical-intervention-for-achalasia-laparoscopic-or-robotic-approach
#5
Samuel S Kim, Jose Guillen-Rodriguez, Alex G Little
Laparoscopic esophageal myotomy is the standard surgical intervention for achalasia. Compared to standard laparoscopic techniques, use of the robot has theoretical advantages of improved visualization and dexterity. We evaluated the University of Arizona's experience with the two alternatives to compare outcomes. Patients who underwent either laparoscopic or robot-assisted myotomy were identified from a retrospective database from 1/1/2006 to 12/31/2015. Patient demographics, prior treatment, intra-operative complications, operative time, post-operative length of stay and complications, and long-term results were compared between the two groups...
September 14, 2018: Journal of Robotic Surgery
https://www.readbyqxmd.com/read/30217846/poisoning-with-soman-an-organophosphorus-nerve-agent-alters-fecal-bacterial-biota-and-urine-metabolites-a-case-for-novel-signatures-for-asymptomatic-nerve-agent-exposure
#6
Derese Getnet, Aarti Gautam, Raina Kumar, Allison Hoke, Amrita K Cheema, Franco Rossetti, Caroline R Schultz, Rasha Hammamieh, Lucille A Lumley, Marti Jett
The experimental pathophysiology of organophosphorus (OP) chemical exposure has been extensively reported. Here, we describe an altered fecal bacterial biota and urine metabolome that follows intoxication with soman, a lipophilic G class chemical warfare nerve agent. Non-anaesthetized Sprague-Dawley male rats were subcutaneously administered soman at 0.8 (sub-seizurogenic) or 1.0 (seizurogenic) of the median lethal dose (LD50 ) and evaluated for signs of toxicity. Animals were stratified based on seizing activity to evaluate effects of soman exposure on fecal bacterial biota and urine metabolites...
September 14, 2018: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/30217708/outcomes-following-lower-extremity-revascularization-for-treatment-of-critical-limb-ischemia-with-tissue-loss-in-patients-with-chronic-immune-mediated-inflammatory-disease
#7
Monica S O'Brien-Irr, Maciej L Dryjski, H Hasan Dosluoglu, Sherif Shalaby, Gregory Cherr, Mariel Rivero, Dimitrios Kuoduomas, Linda M Harris
OBJECTIVE: To evaluate outcomes following lower extremity revascularization for critical limb ischemia with tissue loss in patients with chronic immune mediated inflammatory disease. METHODS: A retrospective medical record review of all lower extremity revascularization for critical limb ischemia with tissue loss at a University affiliated hospital over a 3 year period was completed for demographics, co-morbidities, lower extremity revascularization indication, angiogram results, complications, mortality, limb salvage and re-intervention...
September 11, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/30199502/a-polymer-based-extended-release-system-for-stable-long-term-intracochlear-drug-delivery
#8
Erik Pierstorff, Shanshan Chen, Maria Paola Chaparro, John M Cortez, Yen-Jung Chen, Su Young Ryu, Sherry M Tsai, Marc M Baum, Wan Wan Yang, Federico Kalinec, Thomas Smith, Stacey Ludwig, William H Slattery
OBJECTIVE: Investigate a new polymer-based drug coating suitability for safe intracochlear delivery and ability to maintain long-term physiologically active levels of the corticosteroid fluticasone propionate. STUDY DESIGN: In vitro dissolution study to evaluate release profiles of polymer-coated drug particles and in vivo studies using a guinea pig model to measure perilymph drug concentrations at specific time points after implantation with polymer-coated drug particles and evaluate their effect on hearing function...
October 2018: Otology & Neurotology
https://www.readbyqxmd.com/read/30198925/elevated-presepsin-is-associated-with-perioperative-major-adverse-cardiovascular-and-cerebrovascular-complications-in-elevated-risk-patients-undergoing-noncardiac-surgery-the-leukocytes-and-cardiovascular-perioperative-events-study
#9
Jessica Handke, Anna S Scholz, Hans-Jörg Gillmann, Henrike Janssen, Sarah Dehne, Christoph Arens, Laura Kummer, Florian Uhle, Markus A Weigand, Johann Motsch, Jan Larmann
BACKGROUND: Perioperative major adverse cardiovascular and cerebrovascular events (MACCEs) are incompletely understood, and risk prediction is imprecise. Atherogenic leukocytes are crucial in cardiovascular events. However, it is unclear if surgical interventions affect leukocyte counts or activation status. Therefore, we investigated whether noncardiac surgery in patients with elevated cardiovascular risk is associated with changes in atherogenic leukocyte subsets and if these changes are related to perioperative MACCEs...
September 5, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/30197714/treatment-of-type-two-slap-lesion-with-anatomic-suture-anchor-repair-without-biceps-tenotomy-or-tenodesis
#10
Chadwick C Prodromos, Susan Finkle, Alexander Dawes, Ji Young Baik
Background: Poor results after repair of type 2 SLAP tears are relatively common and some have reported better results after biceps tenodesis or tenotomy than repair. In addition, some believe that the long head of the biceps is expendable. Therefore, many now favor biceps tenotomy or tenodesis over biceps anchor repair either in all patients or in older patients, reserving SLAP lesion repair only for young athletes. Hypothesis: We hypothesized that repair of the biceps anchor of the labrum would be effective in all patients regardless of age provided that care was taken not to overtighten the labrum and that rotator cuff pain as the primary pain generator had been ruled out...
2018: Open Orthopaedics Journal
https://www.readbyqxmd.com/read/30179259/radioembolization-lung-shunt-estimation-based-on-a-90-y-pretreatment-procedure-a-phantom-study
#11
Britt Kunnen, Sandra van der Velden, Remco Bastiaannet, Marnix G E H Lam, Max A Viergever, Hugo W A M de Jong
PURPOSE: Prior to 90 Y radioembolization, a pretreatment procedure is performed, in which 99m Tc-macroaggerated albumin (99m Tc-MAA) is administered to estimate the amount of activity shunting to the lungs. A high lung shunt fraction (LSF) may impose lower prescribed treatment activity or even impede treatment. Accurate LSF measurement is therefore important, but is hampered by the use of MAA particles, which differ from 90 Y microspheres. Ideally, 90 Y microspheres would also be used for the pretreatment procedure, but this would require the activity to be lower than an estimated safety threshold of about 100 MBq to avoid unintended radiation damage...
September 4, 2018: Medical Physics
https://www.readbyqxmd.com/read/30105738/in-situ-gel-forming-system-for-dual-bmp-2-and-17%C3%AE-estradiol-controlled-release-for-bone-regeneration-in-osteoporotic-rats
#12
Elisabet Segredo-Morales, Ricardo Reyes, María Rosa Arnau, Araceli Delgado, Carmen Évora
The aim of this study was to evaluate the bone regeneration capacity of a Pluronic® F127 (P)-Tetronic®1307 (T) and α-cyclodextrin (CD) supramolecular gel (P-T-CD) in a 11/7/7 ratio containing BMP-2 and 17β-estradiol pre-encapsulated in poly-lactide-co-glycolide (PLGA) and poly-lactic acid (PLA-S) microspheres, respectively. Ovariectomy combined with dexamethasone treatment was used to induce an osteoporotic (OP) animal model of calvaria critical size defect in female rats to test the system. The two active substances showed a biphasic in vitro release profile characterized by an initial fast phase followed by a slow and prolonged release...
October 2018: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/30089587/eortc-qlq-c30-summary-score-reliably-detects-changes-in-qol-three-months-after-anatomic-lung-resection-for-non-small-cell-lung-cancer-nsclc
#13
Cecilia Pompili, Michael Koller, Galina Velikova, Kevin Franks, Kate Absolom, Matthew Callister, Jonathan Robson, Andrea Imperatori, Alessandro Brunelli
INTRODUCTION: We tested the European Organization for Research and Treatment of Cancer Quality of Life (EORTC QLQ-C30) summary score (SumSC) to detect changes in the HRQOL after Non-small-cell lung cancer (NSCLC) surgery and compared its performance to the traditional scales. METHOD: EORTC QLQ-C30 data was obtained from 326 consecutive pre-operative patients submitted for anatomical lung resections for NSCLC.66 patients completed post-operative assessments 3 months after surgery...
September 2018: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/30062524/observed-changes-in-brown-white-hepatic-and-pancreatic-fat-after-bariatric-surgery-evaluation-with-mri
#14
Steve C N Hui, Simon K H Wong, Qiyong Ai, David K W Yeung, Enders K W Ng, Winnie C W Chu
OBJECTIVES: To study the change in brown and white adipose tissue (BAT and WAT), as well as fat content in the liver and pancreas, in patients with morbid obesity before and after bariatric surgery. METHODS: Twelve patients with morbid obesity (F=8, M=4, age: 45.4 years (38.4-51.2), BMI: 35.2 kg/m2 (32.5-38.6)) underwent pre-op MRI at baseline and two post-op scans at 6-month and 12-month intervals after bariatric surgery. Co-registered water, fat, fat-fraction and T2* image series were acquired...
July 30, 2018: European Radiology
https://www.readbyqxmd.com/read/30060788/combined-intravitreal-triamcenolone-acetonide-and-bevacizumab-for-refractory-diabetic-macular-edema
#15
Muhammad Aamir Arain, Waqar Muzaffar, Omer Farooq, Muhammad Naeem Azhar
OBJECTIVE: To evaluate the effectiveness of combined Intravitreal triamcinolone acetonide (IVTA) and Intravitreal Bevacizumab (IVB) for treatment of refractory diabetic macular edema. STUDY DESIGN: Quasi-experimental study. PLACE AND DURATION OF STUDY: Armed Forces Institute of Ophthalmology (AFIO), Rawalpindi, from January to December 2017. METHODOLOGY: Pseudophakic diabetic patients with macular edema refractory to prior treatment were included...
August 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/30045343/opioid-utilization-following-lumbar-arthrodesis-trends-and-factors-associated-with-long-term-use
#16
Piyush Kalakoti, Nathan R Hendrickson, Nicholas A Bedard, Andrew J Pugely
STUDY DESIGN: A retrospective, observational cohort study. OBJECTIVE: In patients undergoing lumbar spine arthrodesis, we sought to establish perioperative trends in chronic versus naive opioid users (OUs) and identify modifiable risk factors associated with prolonged consumption. SUMMARY OF BACKGROUND DATA: The morbidity associated with excessive opioid use for chronic conditions continues to climb and has been identified as a national epidemic...
September 1, 2018: Spine
https://www.readbyqxmd.com/read/30035265/post-tonsillectomy-taste-dysfunction-myth-or-reality
#17
REVIEW
Liuba Soldatova, Richard L Doty
Lingual branches of the glossopharyngeal nerve (CN Ⅸ) are at risk of injury during tonsillectomy due to their proximity to the muscle layer of the palatine tonsillar bed. However, it is unclear how often this common surgery leads to taste disturbances. We conducted a literature search using PubMed, Embase, Cochrane Library, Google Scholar, PsychInfo, and Ovid Medline to evaluate the available literature on post-tonsillectomy taste disorders. Studies denoting self-reported dysfunction, as well as those employing quantitative testing, i...
March 2018: World Journal of Otorhinolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/30007267/link-between-estrogen-deficiency-osteoporosis-and-susceptibility-to-bone-metastases-a-way-towards-precision-medicine-in-cancer-patients
#18
REVIEW
F Salamanna, V Borsari, D Contartese, N Nicoli Aldini, M Fini
Different fields of cancer management consider bone health to be of increasing clinical importance for patients: 1) presence of bone metastases in many solid tumors, 2) use of bone-targeted treatments in the reduction of bone metastasis, 3) effects of cancer treatment on reproductive hormones, critical for normal bone remodeling maintenance. Additionally, bone microenvironment is further complicated by the decline of ovarian sex steroid production and by the related increase in inflammatory factors linked to menopause, which result in accelerated bone loss and increased risk of osteoporosis (OP)...
October 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29997897/delayed-cord-clamping-during-elective-cesarean-deliveries-results-of-a-pilot-safety-trial
#19
Caroline J Chantry, Aubrey Blanton, Véronique Taché, Laurel Finta, Daniel Tancredi
Background: Delayed cord clamping (DCC) results in decreased iron deficiency in infancy. The American College of Obstetrics and Gynecology has called for research on the optimal time to clamp the cord during cesarean deliveries (CD). Our objective was to conduct a pilot trial examining the safety of delayed cord clamping (DCC) for maternal-infant dyads during elective cesarean delivery (CD). Methods: We enrolled 39 dyads [23 at 90 s, 16 at 120 s; (DCC Pilot)] between 10/2013 and 9/2014...
2018: Maternal Health, Neonatology and Perinatology
https://www.readbyqxmd.com/read/29989926/learning-based-segmentation-of-ct-brain-images-application-to-postoperative-hydrocephalic-scans
#20
Venkateswararao Cherukuri, Peter Ssenyonga, Benjamin C Warf, Abhaya V Kulkarni, Vishal Monga, Steven J Schiff
OBJECTIVE: Hydrocephalus is a medical condition in which there is an abnormal accumulation of cerebrospinal fluid (CSF) in the brain. Segmentation of brain imagery into brain tissue and CSF [before and after surgery, i.e., preoperative (pre-op) versus postoperative (post-op)] plays a crucial role in evaluating surgical treatment. Segmentation of pre-op images is often a relatively straightforward problem and has been well researched. However, segmenting post-op computational tomographic (CT) scans becomes more challenging due to distorted anatomy and subdural hematoma collections pressing on the brain...
August 2018: IEEE Transactions on Bio-medical Engineering
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