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Afsaneh Amouzegar, Bimalangshu R Dey, Thomas R Spitzer
Although peripheral blood stem cells (PBSC) have worldwide become the predominant source of progenitor cells for hematopoietic stem cell transplantation (HSCT), debate about their role compared with bone marrow (BM) has recently intensified, in large part based on the results of a multicenter Clinical Trials Network study which showed lower incidence of chronic graft-versus-host disease (cGVHD) and improved quality of life in recipients of myeloablative HLA-matched unrelated BM compared with PBSC transplants...
November 12, 2018: Transfusion Medicine Reviews
Jeffrey Quek, Jing Jing Lee, Francesca Lorraine Lim, Colin Diong, Yeow Tee Goh, Sathish Gopalakrishnan, Aloysius Ho, William Hwang, Mickey Koh, Yvonne Loh, Yeh Ching Linn
BACKGROUND: Hemolysis at the time of graft infusion is one of the immediate complications in major ABO-incompatible allogeneic hematopoietic stem cell transplants (HSCTs). We conducted a retrospective analysis to evaluate the efficacy of donor-type fresh frozen plasma (FFP) in reducing isohemagglutinin titer and preventing hemolysis, as well as its effect on delayed red cell engraftment. MATERIALS AND METHODS: This is a single-center study on a series of 380 allogeneic HSCT between 2005 and 2015; of which 99 were either major (n = 74) or bidirectional (n = 25) ABO mismatched...
November 22, 2018: Transfusion
Michael A Pulsipher, Brent R Logan, Pintip Chitphakdithai, Deidre M Kiefer, Marcie L Riches, J Douglas Rizzo, Paolo Anderlini, Susan F Leitman, James W Varni, Hati Kobusingye, RaeAnne M Besser, John P Miller, Rebecca J Drexler, Aly Abdel-Mageed, Ibrahim A Ahmed, Luke P Akard, Andrew S Artz, Edward D Ball, Ruthee-Lu Bayer, Carolyn Bigelow, Brian J Bolwell, E Randolph Broun, Nancy J Bunin, David C Delgado, Katharine Duckworth, Christopher C Dvorak, Theresa E Hahn, Ann E Haight, Parameswaran N Hari, Brandon M Hayes-Lattin, David A Jacobsohn, Ann A Jakubowski, Kimberly A Kasow, Hillard M Lazarus, Jane L Liesveld, Michael Linenberger, Mark R Litzow, Walter Longo, Margarida Magalhaes-Silverman, John M McCarty, Joseph P McGuirk, Shahram Mori, Vinod K Prasad, Scott D Rowley, Witold B Rybka, Indira Sahdev, Jeffrey R Schriber, George B Selby, Paul J Shaughnessy, Shalini Shenoy, Thomas Spitzer, William T Tse, Joseph P Uberti, Madhuri Vusirikala, Edmund K Waller, Daniel J Weisdorf, Gregory A Yanik, Willis H Navarro, Mary M Horowitz, Galen E Switzer, Bronwen E Shaw, Dennis L Confer
The development of reduced intensity approaches for allogeneic hematopoietic cell transplantation has resulted in growing numbers of older related donors (RD) of PBSC. The effects of age on donation efficacy, toxicity, and long-term recovery in RD are poorly understood. To address this we analyzed hematologic variables, pain, donation-related symptoms and recovery in 1211 related PBSC donors aged 18-79 enrolled in the Related Donor Safety Study (RDSafe). RD >60 had a lower median CD34+ level pre-apheresis compared to younger RD (age >60, 59 × 106 /L; age 41-60, 81 × 106 /L; age 18-40, 121 × 106 /L; p<0...
November 10, 2018: Biology of Blood and Marrow Transplantation
Salah Ali, Sami AlThubaiti, Samuele Renzi, Joerg Krueger, K Y Chiang, Ahmed Naqvi, Tal Schechter, Angela Punnett, Muhammad Ali
EBV-related PTLD developing after HSCT is a potentially life-threatening disease. HLH is uncommon after allogeneic HSCT. Data on outcome of patients with PTLD and concomitant HLH after allogeneic HSCT are limited. In this retrospective study, we collected demographic, clinical, laboratory, and outcome data for 408 patients who underwent allogeneic HSCT from 2006 to 2015. Graft source included CB (n = 135; 33.1%), PBSCs (n = 34; 8.3%), and BM (n = 239; 58.6%). Eight out of 408 patients (2%) developed EBV-PTLD with a median age at HSCT of 5...
November 11, 2018: Pediatric Transplantation
Serife Solmaz, Selda Kahraman, Omur Gokmen Sevindik, Celal Acar, Munire Turkyilmaz, Inci Alacacioglu, Ozden Piskin, Mehmet Ali Ozcan, Hayri Guner Ozsan, Bulent Undar, Fatih Demirkan
Peripheral blood is the prefered source for hematopoietic stem cells for hematopoietic stem cell transplantation. The efficiency of peripheral blood stem cell (PBSC) collection can vary among devices. In this study we aimed to compare feasibility and effectivity of apheresis procedures of the different systems. Two apheresis systems [Com.Tec (Fresenius Healthcare) and Spectra Optia (Caridian BCT)] were used in our center for the collection of PBSCs for autologous and allogeneic transplantation. We retrospectively analysed 190 apheresis procedures performed in healthy donors and patients between June 2012 and November 2014 in Department of Hematology, Dokuz Eylul University...
October 2018: Indian Journal of Hematology & Blood Transfusion
Zonghuai Zhang, Beibei He, Liangjian Chen, Huanwen Wang, Rui Wang, Ling Zhao, Yansheng Gong
The development of efficient, robust and low-cost catalyst for water electrolysis is critically important for renewable energy conversion. Herein, we fulfil a significant improvement on electrocatalytic activity for both oxygen-evolution reaction (OER) and hydrogen-evolution reaction (HER) by constructing a novel hierarchical PrBa0.5Sr0.5Co2O5+δ (PBSC)@FeOOH hybrid catalyst. The optimized PBSC@FeOOH-20 catalyst consisted of layered perovskite PBSC nanorods and 20 nm thick amorphous FeOOH nanoflakes exhibits an excellent electrocatalytic activity for OER and HER in 0...
October 15, 2018: ACS Applied Materials & Interfaces
Ricardo Melendez-Munoz, Rachel Marchalik, Theresa Jerussi, Dimana Dimitrova, Veronique Nussenblatt, Andrea Beri, Khalid Rai, Jennifer S Wilder, A John Barrett, Minoo Battiwalla, Richard W Childs, Courtney D Fitzhugh, Daniel H Fowler, Terry J Fry, Ronald E Gress, Matthew M Hsieh, Sawa Ito, Elizabeth M Kang, Steven Z Pavletic, Nirali N Shah, John F Tisdale, Juan Gea-Banacloche, Christopher G Kanakry, Jennifer A Kanakry
Human cytomegalovirus (CMV) infection and disease remains a significant cause of morbidity and mortality for hematopoietic cell transplantation (HCT) recipients. Disruption of or weak reconstitution of virus-specific cellular immune function, such as with certain HCT approaches, poses significant risk for CMV-related complications. The incidence of and risk factors for CMV infection and the nature of CMV disease were evaluated retrospectively among 356 consecutive HCT recipients transplanted at the National Institutes of Health using all graft sources, including bone marrow, peripheral blood stem cell (PBSC), and umbilical cord blood (UCB), and a range of in vivo and ex vivo approaches for graft-versus-host disease (GVHD) prophylaxis...
October 18, 2018: Biology of Blood and Marrow Transplantation
Annette Künkele, Christopher Brown, Adam Beebe, Stephanie Mgebroff, Adam J Johnson, Agne Taraseviciute, Lisa S Rolczynski, Cindy A Chang, Olivia C Finney, Julie R Park, Michael C Jensen
Cytotoxic chemotherapy and radiation can render lymphocyte repertoires qualitatively and quantitatively defective. Thus, heavily treated patients are often poor candidates for the manufacture of autologous chimeric antigen receptor (CAR)-T cell products. In the United States and Europe, children with high-risk neuroblastoma undergo apheresis early in the course of treatment to collect peripheral blood stem cells (PBSCs) for cryopreservation in preparation for high-dose chemotherapy followed by autologous stem cell rescue...
October 10, 2018: Biology of Blood and Marrow Transplantation
Koichi Miyamura
In other countries, unrelated donor peripheral blood stem cell transplantation (PBSCT) is more prevalent than bone marrow transplantation; however, in Japan, it was introduced in 2010 after confirming the safety of donors. PBSCT does not require blood donation, general anesthesia, or frequent bone marrow aspiration of the donor. After PBSCT, numerous hematopoietic cells can prompt blood recovery and engraftment, which has enabled reduced intensity transplantation in elderly patients and patients with concurrent diseases, such as infection...
2018: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
Anna Margret Halldorsdottir, Sveinlaug Atladottir, Margret A Thorsteinsdottir, Niels A Arnason, Gudmundur Runarsson, Torbjorn Jonsson, Olafur E Sigurjonsson, Sigrun Reykdal
BACKGROUND: Prior to infusion, cryopreserved autologous peripheral blood stem cell (auto-PBSC) grafts can either be thawed at the bedside or thawed and washed at the laboratory. At our center, manual washing of grafts prior to infusion was discontinued in April 2012 and bedside thawing was implemented. METHODS: This study compares the outcomes of two patient groups who received auto-PBSC either after post-thaw washing (n = 84) or bedside thawing (n = 83). RESULTS: No life-threatening infusion-related side effects were reported in either group...
2018: Acta Haematologica
Shin-Ichi Fuchida, Kazutaka Sunami, Morio Matsumoto, Hirokazu Okumura, Tohru Murayama, Toshihiro Miyamoto, Eichi Otsuka, Naohito Fujishima, Tohru Izumi, Shigehisa Tamaki, Yasushi Hiramatsu, Yoshiaki Kuroda, Chihiro Shimazaki, Koichi Akashi, Mine Harada
The efficacy and safety of lenalidomide (LEN) consolidation therapy and subsequent LEN maintenance therapy after high-dose therapy with autologous peripheral blood stem cell transplantation (auto-PBSCT) were evaluated in patients with newly diagnosed symptomatic multiple myeloma (MM). Forty-one patients were enrolled and received high-dose dexamethasone (DEX) therapy as an initial induction. The patients who did not respond to the DEX therapy were further treated with four cycles of bortezomib plus DEX (BD) induction therapy...
October 4, 2018: International Journal of Hematology
Nicole Arlt, Remo Rothe, Susann Sielaff, Thomas Juretzek, Heidrun Peltroche, Rainer Moog
BACKGROUND: Sterility testing of peripheral blood stem cells (PBSCs) is mandatory before release. As antibiotic treatment of the PBSC donor may result in false-negative results, PBSC matrix validation must be carried out. STUDY DESIGN AND METHODS: Three spiked PBSCs and a buffy coat (BC; control matrix) were analyzed using the blood culture device BacT/ALERT 3D with the low-temperature module. Samples were spiked with Staphylococcus aureus, Bacillus subtilis, Pseudomonas aeruginosa, Candida albicans, Aspergillus brasiliensis, Clostridium sporogenes, and Propionibacterium acnes...
September 27, 2018: Transfusion
Katharina Kriegsmann, Maurizio Wack, Petra Pavel, Anita Schmitt, Mark Kriegsmann, Thomas Bruckner, Carsten Müller-Tidow, Patrick Wuchter
Many transplantation centers routinely collect 1 or more autologous peripheral blood stem cell (PBSC) grafts in patients with hemato-oncologic and autoimmune disorders. However, subsequent high-dose chemotherapy and autologous blood stem cell transplantation (ABSCT) are often not performed, for various reasons. Currently, little is known about the actual utilization rate of stored PBSCs. We retrospectively analyzed the collection, storage, and disposal practices of PBSC products from a large cohort of patients (n = 1020) with hematologic, oncologic, and autoimmune disorders at our institution over a 12-year period...
September 20, 2018: Biology of Blood and Marrow Transplantation
Sangho Kim, Kenji Hosoya, Ayumi Kobayashi, Masahiro Okumura
Peripheral blood stem cell (PBSC) transplantation following consolidation therapy is a feasible treatment option for canine hematological malignancies. In veterinary medicine, hematopoietic stem cells are generally mobilized into peripheral circulation using a granulocyte colony stimulating factor (G-CSF). This pilot study aimed to evaluate the hematopoietic stem cell mobilization effect of three different regimens for PBSC apheresis with Spectra Optia continuous mononuclear cell (CMNC) protocol in healthy dogs...
September 17, 2018: Veterinary and Comparative Oncology
Uday Kulkarni, Anup J Devasia, Anu Korula, N A Fouzia, P N Nisham, Yasir J Samoon, Kavitha M Lakshmi, Aby Abraham, Alok Srivastava, Vikram Mathews, Biju George
Autologous transplantation is the standard of care for transplant-eligible patients with multiple myeloma. Toward making this treatment accessible in developing countries, there are significant challenges like resource constraints and access to cryopreservation facilities. We performed a retrospective analysis of patients with multiple myeloma who underwent autologous transplantation using granulocyte colony-stimulating factor (G-CSF)-mobilized non-cryopreserved grafts at our institution from January 1995 to December 2014...
August 22, 2018: Biology of Blood and Marrow Transplantation
Wallace Bourgeois, Angela Ricci, Zhezhen Jin, Matt Hall, Diane George, Monica Bhatia, James Garvin, Prakash Satwani
The costs associated with allogeneic hematopoietic cell transplantation (alloHCT) are high. Differences in costs and healthcare utilization among potential donor sources for alloHCT are not well characterized in pediatric recipients of alloHCT. One potential reason for these high costs could be the donor source of hematopoietic cells. In this retrospective study, inpatient costs, outpatient costs, and markers of healthcare utilization associated with unrelated donor alloHCT for malignant and non-malignant disease were analyzed for 131 pediatric patients during the first year post-transplant, for whom the donor sources were 38% umbilical cord blood (UCB), 14% unmanipulated peripheral blood stem cell (PBSC), 26% bone marrow (BM), and 22% PBSC with CD-34 selection...
August 20, 2018: Bone Marrow Transplantation
Senem Maral, Murat Albayrak, Cigdem Pala, Abdulkerim Yildiz, Osman Sahin, Hacer Berna Ozturk
Various side effects associated with dimethyl sulfoxide (DMSO) which is used for cryopreservation of bone marrow or peripheral blood progenitor cells (PBPCs) have been reported. Among the central nervous system side effects the epileptic seizures, stroke, transient and temporary leucoencephalopathy, and global amnesia are well known. Herein we report a 52-year-old man who experienced tonic-clonic seizure within minutes after the initiation of DMSO cryopreserved autologous PBPC infusion. Unfortunately, he also developed cardiac arrest and required intubation for ventilation after the seizure...
August 11, 2018: Cell and Tissue Banking
Erica Dahl Warlick, Todd E DeFor, Nelli Bejanyan, Shernan Holtan, Margaret MacMillan, Bruce R Blazar, Kathryn Dusenbery, Mukta Arora, Veronika Bachanova, Sarah Cooley, Aleksandr Lazaryan, Philip McGlave, Jeffrey S Miller, Armin Rashidi, Arne Slungaard, Gregory Vercellotti, Celalettin Ustun, Claudio Brunsein, Daniel Weisdorf
Reduced-intensity conditioning (RIC) extends the curative potential of allogeneic hematopoietic cell transplantation (HCT) to patients with hematologic malignancies unable to withstand myeloablative conditioning. We prospectively analyzed the outcomes of 292 consecutive patients, median age 58 years (range, 19 to 75) with hematologic malignancies treated with a uniform RIC regimen of cyclophosphamide, fludarabine, and total body irradiation (200 cGy) with or without antithymocyte globulin and cyclosporine and mycophenolate mofetil graft-versus-host disease (GVHD) prophylaxis followed by allogeneic HCT at the University of Minnesota from 2002 to 6...
August 1, 2018: Biology of Blood and Marrow Transplantation
L S Liao, Z H Zheng, T N Wei, S Qu, Y Xie, Z H Wang, B Y Chen
Objective: To study the effect and safety of the DA-EPOCH chemotherapy combined with G-CSF and the MA chemotherapy combined with G-CSF on mobilizing and collecting the peripheral blood stem cells and the later hematopoietic recovery. Methods: A total of 40 patients accepted mobilization and collection of peripheral blood stem cells(PBSC) after being treated by DA-EPOCH+ G-CSF and MA+ G-CSF therapy respectively, and performed auto-transfusion. The effect of mobilization, the adverse effects and the hematopoietic recovery after autologous transplantation were analyzed retrospectively...
July 10, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
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