Jing Li, Zi-Yue Ma, Yun-Feng Cui, Ying-Tao Cui, Xian-Hui Dong, Yong-Zhen Wang, Yu-Yang Fu, Ya-Dong Xue, Ting-Ting Tong, Ying-Zi Ding, Ya-Mei Zhu, Hai-Jun Huang, Ling Zhao, Hong-Zhao Lv, Ling-Zhao Xiong, Kai Zhang, Yu-Xuan Han, Tao Ban, Rong Huo
Malignant ventricular arrhythmia (VA) after myocardial infarction (MI) is mainly caused by myocardial electrophysiological remodeling. Brahma-related gene 1 (BRG1) is an ATPase catalytic subunit that belongs to a family of chromatin remodeling complexes called Switch/Sucrose Non-Fermentable Chromatin (SWI/SNF). BRG1 has been reported as a molecular chaperone, interacting with various transcription factors or proteins to regulate transcription in cardiac diseases. In this study, we investigated the potential role of BRG1 in ion channel remodeling and VA after ischemic infarction...
October 25, 2023: Acta Pharmacologica Sinica