keyword
https://read.qxmd.com/read/38546954/perspectives-in-the-treatment-of-antibiotic-resistant-bacterial-infections-with-active-photodynamic-partners-within-the-framework-of-the-eurestop-cost-action-ca21145
#1
JOURNAL ARTICLE
Mattia Mori, Fabienne Dumoulin, M Amparo F Faustino, Kristjan Plaetzer
The European Network for diagnosis and treatment of antibiotic-resistant bacterial infections-EURESTOP COST Action CA21145 focuses on tackling the burden of antimicrobial resistance (AMR) and has gathered many members working on photodynamic approaches. This European consortium is presented here in the One Health context, to highlight the potential of antimicrobial photodynamic therapy (aPDT) in the fight against AMR.
March 28, 2024: Photochemical & Photobiological Sciences
https://read.qxmd.com/read/38546951/insights-on-the-genomic-diversity-virulence-and-resistance-profile-of-a-campylobacter-jejuni-strain-isolated-from-a-hospitalized-patient-in-brazil
#2
JOURNAL ARTICLE
Carolina Nogueira Gomes, Miliane Rodrigues Frazão, Amanda Aparecida Seribelli, Dillon Oliver Reese Barker, Emily Victoria Che, Mara Corrêa Lelles Nogueira, Eduardo Napoleon Taboada, Juliana Pfrimer Falcão
Campylobacteriosis is currently recognized as one of the major causes of foodborne bacterial diseases worldwide. In Brazil, there is insufficient data to estimate the impact of Campylobacter in public health. The aim of this present study was to characterize a C. jejuni CJ-HBSJRP strain isolated from a hospitalized patient in Brazil by its ability to invade human Caco-2 epithelial cells, to survive in U937 human macrophages, and to assess its phenotypic antimicrobial resistance profile. In addition, prophages, virulence and antimicrobial resistance genes were search using whole-genome sequencing data...
March 28, 2024: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]
https://read.qxmd.com/read/38546430/production-of-lipopeptides-from-bacillus-velezensis-bvq121-and-their-application-in-chitosan-antibacterial-coating
#3
JOURNAL ARTICLE
Rong Qian, Xinyu Ji, Xiaoqi Xu, Sha Li, Hong Xu
The extracellular substance of Bacillus has antibacterial effects inhibiting multiple foodborne pathogens and plays important roles in food production. This study found one Bacillus velezensis BVQ121 strain producing antibacterial lipopeptides (BVAL). After optimization of the fermentation conditions, the BVAL yield was the highest at 1.316 ± 0.03 g/L in reality with the initial pH 6.0, temperature 31 °C, and shaker speed 238 rpm when the optimal nitrogen and carbon sources were used in Landy medium for fermentation...
March 28, 2024: Journal of Agricultural and Food Chemistry
https://read.qxmd.com/read/38546344/pillar-n-arenes-in-the-fight-against-biofilms-current-developments-and-future-perspectives
#4
REVIEW
Sekar Jothi Nayaki, Arivazhagan Roja, Ramya Ravindhiran, Karthiga Sivarajan, Murugan Arunachalam, Kavitha Dhandapani
The global surge in bacterial infections, compounded by the alarming escalation of drug-resistant strains, has evolved into a critical public health crisis. Among the challenges posed, biofilms stand out due to their formidable resistance to conventional antibiotics. This review delves into the burgeoning potential of pillar[ n ]arenes, distinctive macrocyclic host molecules, as promising anti-biofilm agents. The review is structured into two main sections, each dedicated to exploring distinct facets of pillar[ n ]arene applications...
March 28, 2024: ACS Infectious Diseases
https://read.qxmd.com/read/38546272/botanicals-as-promising-antimicrobial-agents-for-enhancing-oral-health-a-comprehensive-review
#5
REVIEW
Ekta Narwal, Jairam Choudhary, Manoj Kumar, Ryszard Amarowicz, Sunil Kumar, Radha, Deepak Chandran, Sangram Dhumal, Surinder Singh, Marisennayya Senapathy, Sureshkumar Rajalingam, Muthamilselvan Muthukumar, Mohamed Mekhemar
The mouth houses the second largest diversity of microorganisms in the body, harboring more than 700 bacterial species colonizing the soft mucosa and hard tooth surfaces. Microbes are the cause of several health-related problems, such as dental carries, gingivitis, periodontitis, etc., in the mouth across different age groups and socioeconomic/demographic groups. Oral infections are major health problems that affect the standard of living. Compromised oral health is related to chronic conditions and systemic disorders...
March 28, 2024: Critical Reviews in Microbiology
https://read.qxmd.com/read/38546267/the-staphylococcus-aureus-regulatory-program-in-a-human-skin-like-environment
#6
JOURNAL ARTICLE
Flavia G Costa, Krista B Mills, Heidi A Crosby, Alexander R Horswill
UNLABELLED: Staphylococcus aureus is a Gram-positive pathogen responsible for the majority of skin and soft tissue infections (SSTIs). S. aureus colonizes the anterior nares of approximately 20%-30% of the population and transiently colonizes the skin, thereby increasing the risk of developing SSTIs and more serious infections. Current laboratory models that mimic the skin surface environment are expensive, require substantial infrastructure, and limit the scope of bacterial physiology studies under human skin conditions...
March 28, 2024: MBio
https://read.qxmd.com/read/38546016/prevalence-and-antimicrobial-resistance-profiles-of-mastitis-causing-bacteria-isolated-from-dairy-goats-in-mukurweini-sub-county-nyeri-county-kenya
#7
JOURNAL ARTICLE
Sarah Kabui, Josephine Kimani, Caroline Ngugi, John Kagira
BACKGROUND: Ruminant mastitis continues to be a cause of economic losses in the dairy industry and remains a major public health hazard globally. OBJECTIVES: This cross-sectional study was carried out in Mukurweini Sub-County of Nyeri County, Kenya, to investigate the prevalence of bacteria causing mastitis, risk factors associated with goat mastitis and the antibiotic resistance profiles of bacteria isolated from the goat milk. METHODS: Farm level data on risk factors for mastitis was obtained from 56 farmers using a semi structured questionnaire...
May 2024: Veterinary Medicine and Science
https://read.qxmd.com/read/38545969/-bacterial-acid-tolerance-mechanism-based-on-acid-signal-transduction-system-and-its-applications
#8
JOURNAL ARTICLE
Tong Hu, Shuang Li, Weihong Zhong
The acid signal transduction system can sense the acidic environment and translate it into signals to regulate various acid tolerance mechanisms within bacteria, helping them to cope with the stress of the acidic environment and survive the acidic environments. This review describes several major acid signal transduction systems that play important roles in acid-tolerant bacteria: EvgS/EvgA, PhoQ/PhoP, ArsS/ArsR, and CadC. The structural components of these systems and their regulation of acid-tolerant systems were used to analyze how acid-tolerant bacteria transduce signal in an acid environment to activate the corresponding acid-tolerance mechanisms and cope with the acid stress...
March 25, 2024: Sheng Wu Gong Cheng Xue Bao, Chinese Journal of Biotechnology
https://read.qxmd.com/read/38545287/overcoming-microbial-resuscitation-using-stable-ultrafine-gold-nanosystems
#9
JOURNAL ARTICLE
Anindita Thakur, Pranay Amruth Maroju, Ramakrishnan Ganesan, Jayati Ray Dutta
While ultrafine gold nanosystems (UGNs) are being extensively studied for their antimicrobial activities, hitherto, no report is available on their propensity towards mitigating bacterial resuscitation-a potential factor contributing to the antimicrobial resistance. The investigations herein with two categories of gold nanosystems-modulated for their stability and surface accessibility through glutathione capping-have provided insights into overcoming resuscitation. Additionally, the study cautions that even moderate resistance development in bacteria exposed to nanosystems can result in significant cross-resistance against conventional antibiotics...
March 26, 2024: Nanoscale advances
https://read.qxmd.com/read/38545203/untargeted-metabolomics-uncovers-prime-pathways-linked-to-antibacterial-action-of-citral-against-bacterial-vaginosis-causing-gardnerella-vaginalis-an-in-vitro-and-in-vivo-study
#10
JOURNAL ARTICLE
Ravi Jothi, Arumugam Kamaladevi, Pandiyan Muthuramalingam, Nambiraman Malligarjunan, Shunmugiah Karutha Pandian, Shanmugaraj Gowrishankar
Global increase in recurrence of bacterial vaginosis (BV) and worrisome rise in antimicrobial resistance pose an urgent call for new/novel antibacterial agents. In light of the circumstance, the present study demonstrates the in vitro and in vivo antibacterial activity of a phytochemical citral, with a particular emphasis to elucidate its mechanistic action against Gardnerella vaginalis -a potential cause of BV. Out of 21 phytochemicals screened initially against G. vaginalis , citral was envisaged to be a phenomenal antibacterial agent showing MIC and MBC at 128 μg/mL...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38545125/advances-in-single-cell-sequencing-technology-in-microbiome-research
#11
REVIEW
Yinhang Wu, Jing Zhuang, Yifei Song, Xinyi Gao, Jian Chu, Shuwen Han
With the rapid development of histological techniques and the widespread application of single-cell sequencing in eukaryotes, researchers desire to explore individual microbial genotypes and functional expression, which deepens our understanding of microorganisms. In this review, the history of the development of microbial detection technologies was revealed and the difficulties in the application of single-cell sequencing in microorganisms were dissected as well. Moreover, the characteristics of the currently emerging microbial single-cell sequencing (Microbe-seq) technology were summarized, and the prospects of the application of Microbe-seq in microorganisms were distilled based on the current development status...
July 2024: Genes & Diseases
https://read.qxmd.com/read/38544858/preventing-microbe-colonization-on-avocado-persea-nubigena-var-guatemalensis-through-metabiotic-treatment-a-promising-postharvest-safety-improvement
#12
JOURNAL ARTICLE
Gabriela N Tenea, Evelyn Angamarca, Victor Cifuentes, Jazmin Hidalgo
INTRODUCTION: Lactic acid bacteria (LAB) produce various metabolites (i.e. metabiotics) with inhibitory capacity towards harmful foodborne pathogens. METHODS: This study aimed to design several antimicrobial formulations based on metabiotics obtained from different native LAB species ( Lactobacillus pentosus UTNGt5, Lactococcus lactis UTNGt28, and Weissella cibaria UTNGt21O) and to detect the possible mode of action towards two multidrug resistant Staphylococcus spp...
2024: Frontiers in Microbiology
https://read.qxmd.com/read/38544785/pigs-lacking-the-srcr5-domain-of-cd163-protein-demonstrate-heritable-resistance-to-the-prrs-virus-and-no-changes-in-animal-performance-from-birth-to-maturity
#13
JOURNAL ARTICLE
Clint Nesbitt, Lucina Galina Pantoja, Benjamin Beaton, Ching-Yi Chen, Matt Culbertson, Perry Harms, Justin Holl, Andrzej Sosnicki, Srinu Reddy, Marisa Rotolo, Elena Rice
Porcine reproductive and respiratory syndrome (PRRS) is one of the world's most persistent viral pig diseases, with a significant economic impact on the pig industry. PRRS affects pigs of all ages, causing late-term abortions and stillbirths in sows, respiratory disease in piglets, and increased susceptibility to secondary bacterial infection with a high mortality rate. PRRS disease is caused by a positive single-stranded RNA PRRS virus (PRRSV), which has a narrow host-cell tropism limited to monocyte-macrophage lineage cells...
2024: Frontiers in genome editing
https://read.qxmd.com/read/38544616/unveiling-ureaplasma-a-case-report-of-a-rare-culprit-in-pyelonephritis
#14
Manish Shrestha, Devi Parvathy Jyothi Ramachandran Nair, Shefali Amin, Arpan Pokhrel, Salina Munankami
Ureaplasma species, typically considered commensal organisms of the human urogenital tract, have been implicated in various urinary tract infections (UTIs), including the rare and challenging presentation of pyelonephritis. This case report describes a unique instance of pyelonephritis induced by Ureaplasma , characterized by a negative routine urine culture and a lack of response to empirical antibiotic treatment, highlighting the complexities associated with diagnosing and managing infections caused by atypical pathogens...
February 2024: Curēus
https://read.qxmd.com/read/38544328/understanding-the-effects-of-sub-inhibitory-antibiotic-concentrations-on-the-development-of-%C3%AE-lactamase-resistance-based-on-quantile-regression-analysis
#15
JOURNAL ARTICLE
Portia Mira, Candace Guzman-Cole, Juan C Meza
AIMS: Quantile regression is an alternate type of regression analysis that has been shown to have numerous advantages over standard linear regression. Unlike linear regression, which uses the mean to fit a linear model, quantile regression uses a data set's quantiles (or percentiles), which leads to a more comprehensive analysis of the data. However, while relatively common in other scientific fields such as economic and environmental modeling, it is infrequently used to understand biological and microbiological systems...
March 27, 2024: Journal of Applied Microbiology
https://read.qxmd.com/read/38543843/bacteriophage-host-interactions-and-the-therapeutic-potential-of-bacteriophages
#16
REVIEW
Leon M T Dicks, Wian Vermeulen
Healthcare faces a major problem with the increased emergence of antimicrobial resistance due to over-prescribing antibiotics. Bacteriophages may provide a solution to the treatment of bacterial infections given their specificity. Enzymes such as endolysins, exolysins, endopeptidases, endosialidases, and depolymerases produced by phages interact with bacterial surfaces, cell wall components, and exopolysaccharides, and may even destroy biofilms. Enzymatic cleavage of the host cell envelope components exposes specific receptors required for phage adhesion...
March 20, 2024: Viruses
https://read.qxmd.com/read/38543808/the-medicinal-phage-regulatory-roadmap-for-phage-therapy-under-eu-pharmaceutical-legislation
#17
JOURNAL ARTICLE
Timo Faltus
Bacteriophage therapy is a promising approach to treating bacterial infections. Research and development of bacteriophage therapy is intensifying due to the increase in antibiotic resistance and the faltering development of new antibiotics. Bacteriophage therapy uses bacteriophages (phages), i.e., prokaryotic viruses, to specifically target and kill pathogenic bacteria. The legal handling of this type of therapy raises several questions. These include whether phage therapeutics belong to a specially regulated class of medicinal products, and which legal framework should be followed with regard to the various technical ways in which phage therapeutics can be manufactured and administered...
March 12, 2024: Viruses
https://read.qxmd.com/read/38543771/-xanthomonas-phage-pbr31-classifying-the-unclassifiable
#18
JOURNAL ARTICLE
Rashit I Tarakanov, Peter V Evseev, Ha T N Vo, Konstantin S Troshin, Daria I Gutnik, Aleksandr N Ignatov, Stepan V Toshchakov, Konstantin A Miroshnikov, Ibrahim H Jafarov, Fevzi S-U Dzhalilov
The ability of bacteriophages to destroy bacteria has made them the subject of extensive research. Interest in bacteriophages has recently increased due to the spread of drug-resistant bacteria, although genomic research has not kept pace with the growth of genomic data. Genomic analysis and, especially, the taxonomic description of bacteriophages are often difficult due to the peculiarities of the evolution of bacteriophages, which often includes the horizontal transfer of genes and genomic modules. The latter is particularly pronounced for temperate bacteriophages, which are capable of integration into the bacterial chromosome...
March 6, 2024: Viruses
https://read.qxmd.com/read/38543654/effect-of-the-inoculum-to-substrate-ratio-on-putative-pathogens-and-microbial-kinetics-during-the-batch-anaerobic-digestion-of-simulated-food-waste
#19
JOURNAL ARTICLE
Saanu Victoria Otite, Bhushan P Gandhi, Esther Agyabeng Fofie, Alfonso José Lag-Brotons, Lawrence I Ezemonye, Alastair D Martin, Roger W Pickup, Kirk T Semple
The effects of the inoculum (anaerobic digestion effluent) to substrate (simulated food waste) ratio (ISR) 4.00 to 0.25 on putative pathogens and microbial kinetics during batch mesophilic anaerobic digestion were investigated. Red fluorescent protein labelled (RFPAKN132) Escherichia coli JM105 was introduced as a marker species, and together with the indigenous Clostridium sp., Enterococcus sp., Escherichia coli , and total coliforms were used to monitor pathogen death kinetics. Quantitative polymerase chain reaction was also used to estimate the bacterial, fungal, and methanogenic gene copies...
March 18, 2024: Microorganisms
https://read.qxmd.com/read/38543636/exploration-of-the-vermiculite-induced-bacterial-community-and-co-network-successions-during-sludge-waste-mushroom-co-composting
#20
JOURNAL ARTICLE
Zhaojing Yu, Bin Wang, Xiaoyan Wu, Runlan Yu, Li Shen, Xueling Wu, Jiaokun Li, Yuandong Liu, Weimin Zeng
Vermiculite is a clay mineral with unique physical properties that plays a significant role in plant cultivation, soil remediation, and solid waste management. In this research, we first explored how vermiculite-to-microbe interactions evolved during sludge-waste mushroom residue co-composting. Vermiculite's addition had a substantial impact on the microbial α and β diversities, significantly changed the microbial community pattern, and strengthened the composting nutrient circulation through the formation of more specialist and generalist species...
March 15, 2024: Microorganisms
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