keyword
MENU ▼
Read by QxMD icon Read
search

haemato-oncology

keyword
https://www.readbyqxmd.com/read/30321604/the-use-of-broad-range-bacterial-pcr-in-the-diagnosis-of-infectious-diseases-a-prospective-cohort-study
#1
Jan Tkadlec, Monika Peckova, Lucie Sramkova, Vilem Rohn, David Jahoda, Dominik Raszka, Jan Berousek, Frantisek Mosna, Tomas Vymazal, Milan Kvapil, Pavel Drevinek
OBJECTIVES: Broad-range PCR has the potential to detect virtually any bacterial species via amplification and nucleotide sequencing of a DNA region common to all bacteria. We aimed to evaluate its usefulness and clinical relevance when applied to a wide variety of primary sterile materials. METHODS: A prospective study including 1370 samples (75 heart valves, 151 joint tissue samples, 230 joint aspirates, 848 whole blood samples and 66 culture negative cerebrospinal fluid samples) were studied by using a commercial PCR system for detecting 16S rDNA (Molzym)...
October 12, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/30171804/risk-factors-for-linezolid-induced-thrombocytopenia-in-patients-without-haemato-oncologic-diseases
#2
Go Wun Choi, Ju-Yeun Lee, Min Jung Chang, Young Kyung Kim, Yoonsook Cho, Yun Mi Yu, Euni Lee
This study aimed to describe the occurrence and to evaluate the predictive factors of thrombocytopenia caused by parenteral linezolid in hospitalised patients without haemato-oncologic diseases. Using electronic medical records, a retrospective safety evaluation was performed among all hospitalised adult patients who received parenteral linezolid therapy between January 2005 and June 2016. Of all identified 264 patients with an average age of 63.4 (SD 15.8) years, thrombocytopenia occurred at a rate of 29.2% after an average of 11...
September 1, 2018: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/30150885/rebound-thymic-hyperplasia-after-bone-marrow-transplantation-in-children-with-haemato-oncological-diseases
#3
Taner Arpaci, Barbaros Sahin Karagun
Aim of the study: To evaluate prevalence of rebound thymic hyperplasia (RTH) after bone marrow transplantation (BMT) in paediatric patients with haemato-oncological diseases. Material and methods: Between February 2013 and December 2017, BMT was performed in 189 paediatric patients with haemato-oncological diseases in our institution. Fifty-six patients who underwent at least two chest computed tomography (CT) exams performed before and after BMT were included in the study...
2018: Contemporary Oncology Współczesna Onkologia
https://www.readbyqxmd.com/read/30136180/local-vs-systemic-pulmonary-amyloidosis-impact-on-diagnostics-and-clinical-management
#4
Julius-Valentin Baumgart, Christiane Stuhlmann-Laeisz, Ute Hegenbart, Johanna Nattenmüller, Stefan Schönland, Sandra Krüger, Hans-Michael Behrens, Christoph Röcken
Immunoglobulin-derived light-chain (AL) amyloidosis of lungs and bronchi can appear as a systemic and a local form. While systemic AL amyloidosis may need haemato-oncological care, the localised form can be treated restrained. We re-evaluated 207 specimens of lungs and bronchi sent in for amyloid diagnostics. Amyloid was diagnosed by polarization microscopy using Congo red-stained tissue specimens and classified immunohistochemically. Histoanatomical amyloid distribution patterns were documented as well as additional histological findings...
August 22, 2018: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/29942661/empirical-antimicrobial-treatment-in-haemato-oncological-patients-with-neutropenic-sepsis
#5
REVIEW
Matthias Gerhard Vossen, Christopher Milacek, Florian Thalhammer
Neutropenic sepsis in haemato-/oncological patients is a medical emergency, as infections may show a fulminant clinical course. Early differentiation between sepsis and febrile neutropenic response often proves to be challenging. To assess the severity of the illness, different tools, which are discussed in this article, are available. Once the diagnosis has been established, the correct use of early empirical antibiotic and antifungal treatment is key in improving patient survival. Therefore, profound knowledge of local resistance patterns is mandatory and carefully designed antibiotic regimens have to be established in cooperation with local microbiologists or infectious diseases specialists...
2018: ESMO Open
https://www.readbyqxmd.com/read/29477371/venetoclax-a-new-wave-in-hematooncology
#6
REVIEW
Jana Mihalyova, Tomas Jelinek, Katerina Growkova, Matous Hrdinka, Michal Simicek, Roman Hajek
Inhibitors of antiapoptotic proteins of the BCL2 family can successfully restart the deregulated process of apoptosis in malignant cells. Whereas nonselective agents have been limited by their affinity to different BCL2 members, thus inducing excessive toxicity, the highly selective BCL2 inhibitor venetoclax (ABT-199, Venclexta™) has an acceptable safety profile. To date, it has been approved in monotherapy for the treatment of relapsed or refractory chronic lymphocytic leukemia (CLL) with 17p deletion. Extension of indications can be expected in monotherapy and in combination regimens...
May 2018: Experimental Hematology
https://www.readbyqxmd.com/read/29411124/malignancy-and-chemotherapy-induced-haemophagocytic-lymphohistiocytosis-in-children-and-adolescents-a-single-centre-experience-of-20-years
#7
COMPARATIVE STUDY
Volker Strenger, Gerald Merth, Herwig Lackner, Stephan W Aberle, Harald H Kessler, Markus G Seidel, Wolfgang Schwinger, Daniela Sperl, Petra Sovinz, Anna Karastaneva, Martin Benesch, Christian Urban
Haemophagocytic lymphohistiocytosis (HLH) is a possibly life-threatening syndrome of immune dysregulation and can be divided into primary (hereditary) and secondary forms (including malignancy-associated HLH (M-HLH)). We retrospectively analysed epidemiological, clinical, virological and laboratory data from patients with M-HLH treated at our department between 1995 and 2014. Out of 1.706 haemato-/oncologic patients treated at our department between 1995 and 2014, we identified 22 (1.29%) patients with secondary HLH (1...
June 2018: Annals of Hematology
https://www.readbyqxmd.com/read/29378728/combined-treatment-of-primary-vitreoretinal-lymphomas-significantly-prolongs-the-time-to-first-relapse
#8
Aneta Klimova, Jarmila Heissigerova, Eva Rihova, Michaela Brichova, Robert Pytlik, Ivan Spicka, Katerina Mrazova, Jana Karolova, Petra Svozilkova
BACKGROUND: Vitreoretinal lymphomas belong to the family of central nervous system (CNS) lymphomas. The optimal approach for the treatment of isolated primary vitreoretinal lymphoma is unclear because of the lack of large comparative clinical series. Combination of intravitreal and systemic chemotherapy is recommended in many reports. The aim of our retrospective study was to compare the survival rate and prognosis of patients with vitreoretinal lymphoma with and without CNS involvement...
January 29, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29363748/haematology-patients-and-the-risk-of-transfusion-transmitted-infection
#9
REVIEW
Louise I Ainley, Patricia E Hewitt
A 2014 study by NHS Blood and Transplant indicated that over one quarter of red cells were transfused to patients with haematological conditions. For platelet components, the figure is higher. Certain diagnostic groups, such as haemoglobinopathies, myelodysplastic syndromes and some haemato-oncology patients, receive multiple transfusion episodes, either over long periods, or more intensively over shorter periods. Haematology patients account for the majority of the multi-transfused population. The risk of transfusion-transmitted infection (TTI) increases with number of donor exposures, and the consequences of TTI are often more significant in immunosuppressed individuals...
February 2018: British Journal of Haematology
https://www.readbyqxmd.com/read/29344579/prognostic-significance-of-cytogenetic-heterogeneity-in-patients-with-newly-diagnosed-multiple-myeloma
#10
Maximilian Merz, Anna Jauch, Thomas Hielscher, Tilmann Bochtler, Stefan Olaf Schönland, Anja Seckinger, Dirk Hose, Uta Bertsch, Kai Neben, Marc Steffen Raab, Jens Hillengass, Hans Salwender, Igor Wolfgang Blau, Hans-Walter Lindemann, Ingo G H Schmidt-Wolf, Christof Scheid, Mathias Haenel, Katja C Weisel, Hartmut Goldschmidt
We investigated subclonal cytogenetic aberrations (CA) detected by interphase fluorescence in situ hybridization (iFISH) in patients with newly diagnosed multiple myeloma (MM) enrolled in the Haemato Oncology Foundation for Adults in the Netherlands (HOVON)-65/German-Speaking MM Group (GMMG)-HD4 phase 3 trial. Patients were either treated with 3 cycles of vincristine, Adriamycin, and dexamethasone or bortezomib, Adriamycin, and dexamethasone and then thalidomide or bortezomib maintenance after tandem autologous transplantation...
January 9, 2018: Blood Advances
https://www.readbyqxmd.com/read/29208883/tumor-lysis-syndrome-and-hyperleukocytosis-in-childhood-acute-lymphoblastic-leukemia-in-a-tertiary-care-hospital
#11
R Tasmeen, A Islam, S T Alam, M Begum
Acute lymphoblastic leukemia is the most common (77%) childhood leukemia and also the most common neoplastic disease in children. Acute lymphoblastic leukemia initially present with hyperleukocytosis (WBC count more than 50,000/mm³) in twenty percent cases. These children are particularly at risk of development of tumor lysis syndrome (TLS). Tumor lysis syndrome is a metabolic disorder consists of hyperuricaemia, hyperkalemia, hyperphosphataemia, hypocalcaemia with or without renal insufficiency. It is the most common disease related emergency encountered by physicians caring for cancer of children and adult...
October 2017: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/29207709/isolation-of-the-rare-opportunistic-yeast-saprochaete-capitata-from-clinical-samples-experience-from-a-tertiary-care-hospital-in-southern-india-and-a-brief-review-of-the-literature
#12
Umabala Pamidimukkala, Anuradha Kancharla, Sukanya Sudhaharan, Sadashivudu Gundeti, Surendra Mandarapu, Vamsi Krishna Nagalla, Sree Bhushan Raju, Sandhya Devi Karanam
Introduction: Saprochaete capitata (Teleomorph: Magnusiomyces capitatus ) is a ubiquitous yeast found in environmental sources such as soil, water, air, plants and dairy products. It is also a part of the normal microbial flora in humans. The yeast is being increasingly reported as an opportunistic pathogen, especially in patients in the haemato-oncology setting, the infection being often mistakenly diagnosed as invasive candidiasis. Aim: To review the epidemiological, clinical and microbiological features of six patients admitted in our hospital over a period of 10 years (from January 2007 to December 2016), from whom Saprochaete capitata was isolated...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29126393/genomic-characterisation-of-clinical-and-environmental-pseudomonas-putida-group-strains-and-determination-of-their-role-in-the-transfer-of-antimicrobial-resistance-genes-to-pseudomonas-aeruginosa
#13
Silke Peter, Philipp Oberhettinger, Leonard Schuele, Ariane Dinkelacker, Wichard Vogel, Daniela Dörfel, Daniela Bezdan, Stephan Ossowski, Matthias Marschal, Jan Liese, Matthias Willmann
BACKGROUND: Pseudomonas putida is a Gram-negative, non-fermenting bacterium frequently encountered in various environmental niches. P. putida rarely causes disease in humans, though serious infections and outbreaks have been reported from time to time. Some have suggested that P. putida functions as an exchange platform for antibiotic resistance genes (ARG), and thus represents a serious concern in the spread of ARGs to more pathogenic organisms within a hospital. Though poorly understood, the frequency of ARG exchange between P...
November 10, 2017: BMC Genomics
https://www.readbyqxmd.com/read/29115366/update-on-management-of-invasive-candidiasis
#14
REVIEW
F J Candel, C Pazos Pacheco, I Ruiz-Camps, E Maseda, M R Sánchez-Benito, A Montero, M Puig, F Gilsanz, J Aguilar, M Matesanz
Given the growing incidence of invasive candidiasis in critically ill and haemato-oncological patients and its poor outcomes, an early diagnosis and treatment are need for get a better prognosis. This document reviews the current ap-proaches that help in diagnosis of invasive candidiasis based on culture-independent microbiological tests. The combination of clinical prediction scores with fungal serological markers could facilitate the approach in antifungal therapy, optimiz-ing it. This article also reviews the epidemiology and primary risk factors for invasive candidiasis in these patients, updating the therapeutic approach algorithms in both clinical contexts based on the main evidence and international guidelines...
December 2017: Revista Española de Quimioterapia: Publicación Oficial de la Sociedad Española de Quimioterapia
https://www.readbyqxmd.com/read/29056247/haemato-oncology-patients-perceptions-of-health-related-quality-of-life-after-critical-illness-a-qualitative-phenomenological-study
#15
Geraldine O'Gara, Simon Tuddenham, Natalie Pattison
INTRODUCTION: Haemato-oncology patients often require critical care support due to side-effects of treatment. Discharge can mark the start of an uncertain journey due to the impact of critical illness on health-related quality of life. Qualitatively establishing needs is a priority as current evidence is limited. AIMS: To qualitatively explore perceptions of haemato-oncology patients' health-related quality of life after critical illness and explore how healthcare professionals can provide long-term support...
February 2018: Intensive & Critical Care Nursing: the Official Journal of the British Association of Critical Care Nurses
https://www.readbyqxmd.com/read/28992561/bridging-the-gap-between-the-randomised-clinical-trial-world-and-the-real-world-by-combination-of-population-based-registry-and-electronic-health-record-data-a-case-study-in-haemato-oncology
#16
REVIEW
R E Kibbelaar, B E Oortgiesen, A M van der Wal-Oost, K Boslooper, J W Coebergh, N J G M Veeger, P Joosten, H Storm, E N van Roon, M Hoogendoorn
Randomised clinical trials (RCTs) are considered the basis of evidence-based medicine. It is recognised more and more that application of RCT results in daily practice of clinical decision-making is limited because the RCT world does not correspond with the clinical real world. Recent strategies aiming at substitution of RCT databases by improved population-based registries (PBRs) or by improved electronic health record (EHR) systems to provide significant data for clinical science are discussed. A novel approach exemplified by the HemoBase haemato-oncology project is presented...
November 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28960383/agonist-induced-platelet-reactivity-correlates-with-bleeding-in-haemato-oncological-patients
#17
B Batman, E R van Bladel, M van Hamersveld, P C M Pasker-de Jong, S J A Korporaal, R T Urbanus, M Roest, L A Boven, R Fijnheer
BACKGROUND AND OBJECTIVE: Prophylactic platelet transfusions are administered to prevent bleeding in haemato-oncological patients. However, bleeding still occurs, despite these transfusions. This practice is costly and not without risk. Better predictors of bleeding are needed, and flow cytometric evaluation of platelet function might aid the clinician in identifying patients at risk of bleeding. This evaluation can be performed within the hour and is not hampered by low platelet count...
November 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/28958124/-dyadic-coping-of-patients-with-haemato-oncological-diseases-and-their-partners-discrepancy-indexes-and-association-with-social-support-and-psychological-distress
#18
Rinat Osin, Anna-Luise Pankrath, Dietger Niederwieser, Hartmut Döhner, Klaus Hönig, Martin Vogelhuber, Anja Mehnert, Gregor Weißflog, Jochen Ernst
BACKGROUND: Cancer is often associated with negative psychosocial consequences not only for patients but also for their partners. These consequences are also influenced by the applied coping strategies. OBJECTIVE: The study examines the influence of Dyadic Coping (DC) on social support and psychological distress (symptoms of depression and anxiety) in haemato-oncological patients and their partners. Of particular interest is the significance of dyadic accordance (conformity) of the assessment of DC ("discrepancy indexes")...
February 2018: Psychotherapie, Psychosomatik, Medizinische Psychologie
https://www.readbyqxmd.com/read/28939570/perceptions-of-parents-and-paediatricians-on-pain-induced-by-bone-marrow-aspiration-and-lumbar-puncture-among-children-with-acute-leukaemia-a-qualitative-study-in-china
#19
Yu Wang, Qiang Liu, Jia-Ning Yu, Hai-Xia Wang, Lu-Lu Gao, Ya-Liang Dai, Xin Jin, Feng Zuo, Juan Liu, Cai-Feng Bai, Guo-Xia Mu, Xiao-Min Chai, Yin-Juan Zhang, Yu-Xiang Li, Jian-Qiang Yu
OBJECTIVE: To obtain in-depth insight into the perceptions of parents and paediatricians in China regarding current procedural pain management on bone marrow aspirations and lumbar punctures in paediatric haemato-oncology department. DESIGN, SETTING AND PARTICIPANTS: This qualitative study was conducted in a 4500-bed university hospital in northwest China. To collect data, in-depth semistructured interviews were conducted with parents of children with acute leukaemia (n=12) and haemato-oncology paediatricians (n=11) using purposive sampling...
September 21, 2017: BMJ Open
https://www.readbyqxmd.com/read/28723704/trends-and-territorial-inequalities-of-incidence-and-survival-of-childhood-leukaemia-and-their-relations-to-socioeconomic-status-in-hungary-1971-2015
#20
Zsuzsanna Jakab, Attila Juhasz, Csilla Nagy, Dezso Schuler, Miklos Garami
The Hungarian Childhood Cancer Registry, a population-based national registry of the Hungarian Paediatric Haemato-Oncology Network founded in 1971, monitors the incidence and mortality of childhood cancer. Our aims were to carry out a longitudinal study to investigate the trends and spatial inequalities of incidence and survival of leukaemia, and the association between survival and deprivation in Hungary. All cases of childhood leukaemia and myelodysplasia were analysed (3157 cases, 1971-2015, age: 0-14 years)...
September 2017: European Journal of Cancer Prevention
keyword
keyword
161799
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"