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https://www.readbyqxmd.com/read/28745242/leber-s-heriditary-optic-neuropathy-the-shift-from-an-opthalmologic-disease-to-a-multi-systemic-paradigm
#1
Jasna Jancic, Stevan Stojanovic, Amalija Stojanovic, Ana Marija Milanovic, Blazo Nikolic, Nikola Ivancevic, Janko Samardzic
Leber's hereditary optic neuropathy is an inherited form of optic neuropathy, genetically and based on mitochondrial insufficiency causing bilateral loss of central vision mostly at a young age. Despite being one of the most common mitochondrial diseases, the explanation for its pathophysiological background and effective clinical solutions remain elusive. Widening the scope in the search for pathological findings beyond the optic system has yielded several non-ophthalmologic findings, which might imply that Leber's hereditary optic neuropathy is in fact a multi-systemic disease...
July 24, 2017: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/28653209/-early-onset-of-fingolimod-associated-macular-edema
#2
D Schelenz, I Kleiter, J Schöllhammer, J Rehrmann, M Elling, H B Dick, V Kakkassery
BACKGROUND: Fingolimod, a disease-modifying sphingosine 1‑phosphate receptor modulator, which was approved in Germany in 2011, decreases the relapse rate and reduces neuroinflammation in patients with relapsing-remitting multiple sclerosis. Macular edema is a well-known ocular side effect of fingolimod therapy. Specific intervals for ophthalmologic check-ups after starting fingolimod and definite treatment schedules for fingolimod-associated macular edema are, however, still lacking...
June 26, 2017: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/28643176/a-promising-tool-in-retina-regeneration-current-perspectives-and-challenges-when-using-mesenchymal-progenitor-stem-cells-in-veterinary-and-human-ophthalmological-applications
#3
REVIEW
Anna Cislo-Pakuluk, Krzysztof Marycz
Visual impairment is a common ailment of the current world population, with more exposure to CCD screens and fluorescent lighting, approximately 285 billion people suffer from this deficiency and 13% of those are considered clinically blind. More common causes for visual impairment include age-related macular degeneration (AMD), glaucoma and diabetic retinopathy (Zhu et al. Molecular Medicine Reports, 2015; Kolb et al. 2007; Machalińska et al. Current Eye Research, 34(9),748-760, 2009) among a few. As cases of retinal and optic nerve diseases rise, it is vital to find a treatment, which has led to investigation of the therapeutic potential of various stem cells types (Bull et al...
June 22, 2017: Stem Cell Reviews
https://www.readbyqxmd.com/read/28624248/retinopathy-diabetic-screening-by-non-mydriatic-retinography-concordance-between-primary-care-physicians-nurses-and-ophthalmologists
#4
Susana Rodríguez Villa, María Teresa Suárez Muñiz, Ricardo De Dios Del Valle, Crisanto Alonso Álvarez
AIM: To compare the evaluation of retinographies by a teleophthalmology nurse and primary care physicians (PCP) with an ophthalmologist referral hospital (gold standard). METHODS: Cross-sectional study on a random sample of 337 patients on the teleophthalmology programme from January 2010 to January 2015. We analyzed the diagnostic evaluation (whether or not it presented findings of RD) and the therapeutic assessment (whether or not referral to the opthalmology department was needed) which were conducted independently on the sample retinographies by the PCP, a nurse and an ophthalmologist (gold standard)...
June 14, 2017: Enfermería Clínica
https://www.readbyqxmd.com/read/28588003/pituitary-adenoma-apoplexy-in-an-adolescent-a-case-report-and-review-of-the-literature
#5
Hero Zijlker, Sebastian Schagen, Jan Maarten Wit, Biermasz Nienke, Wouter van Furth, Wilma Oostdijk
We present a 13-year-old boy who became progressively sleepy and experienced a sudden headache with vomiting and fever. Laboratory testing showed hypoglycemia, multiple pituitary hormonal deficiencies and elevated C-Reactive Protein (CRP). A cranial MRI showed an opaque sphenoid sinus and an intrasellar mass suspect for hemorrhage, so that we suspected a pituitary apoplexy (PA) originating from a non-functioning adenoma, although a pituitary abscess could not completely be excluded. The boy was treated with antibiotics, hydrocortisone and levothyroxine and a close follow-up to monitor the clinical course...
June 7, 2017: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/28316023/transconjunctival-versus-subciliary-approach-to-the-infraorbital-margin-for-open-reduction-of-zygomaticomaxillary-complex-fractures-a-randomized-feasibility-study
#6
Mohammad Waheed El-Anwar, Ezzeddin Elsheikh, Atef M Hussein, Adly A Tantawy, Youssef Mansour Abdelbaki
INTRODUCTION: Although some studies addressed the differences between subciliary and transconjunctival approaches, no previous prospective comparative study on displaced zygomaticomaxillary complex (ZMC) fracture that repaired by three-point internal fixation using also upper gingivolabial incision and upper eye lid incision. So, the effect of these incisions on the comparison was not investigated. PURPOSE: The purpose of this study was to compare transconjunctival and subciliary approaches for open reduction and internal rigid fixation (OR/IF) of ZMC fractures...
June 2017: Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28241867/securing-an-otl-hns-residency-how-competitive-is-it-comparing-medical-student-perceptions-to-actual-canadian-statistics
#7
E Kay-Rivest, N Varma, G M Scott, J J Manoukian, M Desrosiers, J P Vaccani, L H P Nguyen
BACKGROUND: The residency match is an important event in an aspiring physician's career. Otolaryngology - Head and Neck Surgery (OTL-HNS) is a surgical specialty that has enjoyed high numbers of applicants to its residency programs. However, recent trends in Canada show a decline in first-choice applicants to several surgical fields. Factors thought to influence a medical student's choice include role models, career opportunities and work-life balance. The notion of perceived competitiveness is a factor that has not yet been explored...
February 27, 2017: Journal of Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28187470/-indications-for-retinal-laser-therapy-revisited
#8
P Enders, F Schaub, S Fauser
Background Laser therapy is an important treatment option in retinal diseases, especially in cases of vascular involvement. Most approaches are based on coagulation of retinal structures. As there is increasing use of agents targetting vascular endothelial growth factor in the treatment of macular diseases, indications for the use of laser treatment need to be reviewed carefully, especially with respect to their significance in first line therapy. This article explains recent strategies and treatment protocols...
February 10, 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/27796155/investigation-of-the-effects-of-systemic-isotretinoin-treatment-on-retinal-nerve-fiber-layer-and-macula
#9
Uğur Yılmaz, Erkut Küçük, Çağdaş Koç, Ayşe Özköse
PURPOSE: To investigate the effects of systemic isotretinoin therapy on retina by measuring retinal nerve fiber layer (RNFL) and macular thicknesses. METHOD: This prospective, cross-sectional study was conducted in patients prescribed systemic isotretinoin therapy. Seventy-two eyes of 36 patients were included in the study. The patients were followed during three months. Detailed ophthalmologic examination including anterior and posterior segment examination, best corrected visual acuity and intraocular pressure measurement, RNFL and macular thicknesses measurement by Spectral Domain Cirrus Optical Coherence Tomography Model 400 (Carl Zeiss Meditech, Jena, Germany) were performed at baseline, first, second and third months after the beginning of systemic isotretinoin therapy in ophthalmology clinic...
June 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/27608700/systemic-lupus-erythematosus-presenting-as-neuroretinitis
#10
Gouranga Santra, Indrani Das
Neuroretinitis is the inflammation of retina and optic nerve. It is associated with optic disc edema accompanied by peripapillary or macular hard exudates. A 17 yr old female presented with headache and nausea of five days duration. She had periorbital edema and mild splenomegaly. Neurological assessment was non-contributory. She was found to have pancytopenia, albuminuria and a high ESR. Thereafter she developed blurring of vision of both eyes. Opthalmological examination showed it to be due to bilateral neuroretinitis...
October 2015: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27575526/-turner-syndrome-study-of-42-cases
#11
M Pilar Bahíllo-Curieses, Pablo Prieto-Matos, Rocío Quiroga González, Laura Regueras Santos, Amaya Blanco Barrio, Sara Rupérez Peña
BACKGROUND AND OBJECTIVE: Turner syndrome (TS) is characterized by short stature, gonadal dysgenesis, and total or partial loss of X chromosome. PATIENTS AND METHODS: A historical cohorts study of patients with TS≤18 years old followed up in public hospitals in Castilla y Leon was undertaken. RESULTS: Forty-two female patients were included (prenatal diagnosis 11.9%, neonatal diagnosis 14.3%) with current median age 11.9±4.2 years. Short stature was the reason for consultation in 87...
October 21, 2016: Medicina Clínica
https://www.readbyqxmd.com/read/27393804/retinal-blood-vessel-extraction-using-tunable-bandpass-filter-and-fuzzy-conditional-entropy
#12
Sudeshna Sil Kar, Santi P Maity
BACKGROUND AND OBJECTIVES: Extraction of blood vessels on retinal images plays a significant role for screening of different opthalmologic diseases. However, accurate extraction of the entire and individual type of vessel silhouette from the noisy images with poorly illuminated background is a complicated task. To this aim, an integrated system design platform is suggested in this work for vessel extraction using a sequential bandpass filter followed by fuzzy conditional entropy maximization on matched filter response...
September 2016: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/27293250/xanthelasma-palpebrarum-with-arcus-cornea-a-clinical-and-biochemical-study
#13
Pragya Ashok Nair, Chaitali R Patel, Jaishree D Ganjiwale, Nilofar Gulamsha Diwan, Nidhi Bhimjibhai Jivani
BACKGROUND: Xanthelasma palpebrarum (XP) is characterized by sharply demarcated yellowish flat plaques on upper and lower eyelids. It is commonly seen in women with a peak incidence at 30-50 years. It is also considered as the cutaneous marker of underlying atherosclerosis along with the disturbed lipid metabolism. XP and corneal arcus are associated with increased levels of serum cholesterol and low-density lipoprotein (LDL) cholesterol. AIMS AND OBJECTIVES: To study the clinical pattern of XP, its relationship with lipid profile and association with arcus cornea...
May 2016: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/26894082/antecedent-drug-exposure-aetiology-and-management-protocols-in-steven-johnson-syndrome-and-toxic-epidermal-necrolysis-a-hospital-based-prospective-study
#14
Samina Farhat, Muddasir Banday, Iffat Hassan
AIM: The study sought to identify the magnitude and characteristic of severe cutaneous adverse reactions (SCAR's) like Steven-Johnson syndrome (SJS) and Toxic Epidermal Necrolysis (TEN). MATERIALS AND METHODS: A prospective study was conducted by the Department of Pharmacology in association with Department of Dermatology in SMHS hospital. The study was carried out from June 2013-June 2015 on hospitalized cases of cutaneous adverse drug reaction reporting in hospital...
January 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/26842341/predictive-factors-for-ocular-complications-caused-by-anticancer-drug-s-1
#15
Rika Yamada, Chie Sotozono, Takahiro Nakamura, Akihiro Nishida, Shinya Nakanishi, Masaki Hirabatake, Akihito Tsuji, Yasuo Kurimoto
PURPOSE: To identify predictive factors for ocular complications caused by the anticancer drug S-1. METHODS: A questionnaire was administered to 39 patients who underwent S-1 chemotherapy at Kobe City Medical Center General Hospital, with the aim to determine whether these patients were aware of the ocular complications caused by S-1. Cognition rate was determined. The 26 patients who requested opthalmological examination for further evaluation studied further and classified into two groups-those who had developed corneal epithelial complications, conjunctival injection or chemosis, or lacrimal duct blockages (referred to as the positive group) and those without these findings (referred to as the negative group)...
March 2016: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/26689876/lyme-disease-associated-neuroretinitis-case-report
#16
Melinda Vanya, Imre Fejes, Maria Jako, Areta Tula, Gabriella Terhes, Marta Janaky, Gyorgy Bartfai
We describe a rare case of Lyme disease complicated by unilateral neuroretinitis in the right eye. We report a case of a 27-year-old woman with blurred vision on her right eye. Because of the suspicion of optic neuritis (multiplex sclerosis) neurological examination was ordered. Surprisingly, computer tomography of the brain revealed incomplete empty sella, which generally results not monocular, but bilateral optic nerve swelling. Opthalmological examination (ophthalmoscopy and optical coherence tomography) indicated not only monocular optic nerve, but retinal oedema next to the temporal part of the right optic disk...
December 2015: Acta Microbiologica et Immunologica Hungarica
https://www.readbyqxmd.com/read/26023269/vision-related-problems-among-the-workers-engaged-in-jewellery-manufacturing
#17
Urmi Ravindra Salve
BACKGROUND: American Optometric Association defines Computer Vision Syndrome (CVS) as "complex of eye and vision problems related to near work which are experienced during or related to computer use." This happens when visual demand of the tasks exceeds the visual ability of the users. Even though problems were initially attributed to computer-related activities subsequently similar problems are also reported while carrying any near point task. Jewellery manufacturing activities involves precision designs, setting the tiny metals and stones which requires high visual attention and mental concentration and are often near point task...
January 2015: Indian Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/25830057/repeated-intramuscular-dose-toxicity-test-of-watersoluble-carthami-flos-wcf-pharmacopuncture-in-sprague-dawley-rats
#18
Yoo-Min Choi, Da-Jung Jung, Seok-Hee Kim, Jong-Uk Kim, Tae-Han Yook
OBJECTIVES: Water-soluble carthami flos (WCF) is a new mixture of Carthami flos (CF) pharmacopuncture. We conducted a 4-week toxicity test of repeated intramuscular injections of WCF in Sprague-Dawley rats. METHODS: Forty male and 40 female rats were divided into 4 groups of 10 male and 10 female SD rats: The control group received 0.5 mL/animal/day of normal saline whereas the three experimental groups received WCF at doses of 0.125, 0.25, and 0.5 mL/animal/day, respectively...
March 2015: Journal of Pharmacopuncture
https://www.readbyqxmd.com/read/25568537/treatment-of-congenital-aniridia-associated-with-subluxated-infantile-cataract
#19
Vahid Jusufovic, Emir Cabric, Allen Popovic-Beganovic, Zlatko Musanovic, Jasmin Zvornicanin
A 5 year old boy was presented at Eye clinic University clinical center Tuzla with congenital aniridia in both eyes. Clinical examination revealed visual acuity of 0,08 without correction in right and 0.7 with -5.0 Dsph and -1.0 Dcyl Axx 109° in left eye. Opthalmologic examination showed bilateral aniridia associated with moderate cataract in the right and incipient cataract in the left eye. In the right eye, zonular weakness with incipient capsular displacement and esotropia of Δ6º, were noted. The patient underwent phacoemulsification, implantation of capsular tension ring and Artificial Iris implant in the capsular bag...
June 2014: Medical Archives
https://www.readbyqxmd.com/read/25546496/poliosis-circumscripta-unmasking-a-scalp-melanoma
#20
L Yeo, E Husain, S Rajpara
A 28-year-old man presented with a 1-year history of a localized patch of grey hair and an underlying darkly pigmented lesion on his right occipital area. Clinical appearance revealed poliosis overlying an asymmetrical plaque with variable degrees of brown pigmentation and white discolouration. Owing to the suspicious nature of the lesion, excision with a 2 mm margin was performed. Histology revealed an invasive melanoma with extensive regression and prominent involvement of multiple hair follicles. Scalp melanoma with associated poliosis is extremely rare, and has only been reported once in the literature to date...
December 2015: Clinical and Experimental Dermatology
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