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Lindsay D Oliver, John D Haltigan, James M Gold, George Foussias, Pamela DeRosse, Robert W Buchanan, Anil K Malhotra, Aristotle N Voineskos
Background: Schizophrenia spectrum disorders (SSDs) often feature social cognitive deficits. However, little work has focused on the factor structure of social cognition, and results have been inconsistent in schizophrenia. This study aimed to elucidate the factor structure of social cognition across people with SSDs and healthy controls. It was hypothesized that a 2-factor model, including lower-level "simulation" and higher-level "mentalizing" factors, would demonstrate the best fit across participants...
August 10, 2018: Schizophrenia Bulletin
Lindsay Horton, Jeffrey L Bennett
The current management of acute optic neuritis (ON) is focused on expediting visual recovery through the use of high-dose intravenous corticosteroids. The recent identification of specific autoantibodies associated with central nervous system inflammatory disorders has provided novel insights into immune targets and mechanisms that impact the prognosis, treatment, and recurrence of ON. Therefore, neurologists and ophthalmologists need to be aware of clinical, laboratory, and imaging findings that may provide important clues to the etiology of ON and the potential need for aggressive management...
September 2018: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
Alfred B Tiono, Alphonse Ouédraogo, Daouda Ouattara, Edith C Bougouma, Sam Coulibaly, Amidou Diarra, Brian Faragher, Moussa W Guelbeogo, Nelson Grisales, Issa N Ouédraogo, Zininwindé Amidou Ouédraogo, Margaret Pinder, Souleymane Sanon, Tom Smith, Fiona Vanobberghen, N'Fale Sagnon, Hilary Ranson, Steve W Lindsay
BACKGROUND: Substantial reductions in malaria incidence in sub-Saharan Africa have been achieved with massive deployment of long-lasting insecticidal nets (LLINs), but pyrethroid resistance threatens control. Burkina Faso is an area with intense malaria transmission and highly pyrethroid-resistant vectors. We assessed the effectiveness of bednets containing permethrin, a pyrethroid, and pyriproxyfen, an insect growth regulator, versus permethrin-only (standard) LLINs against clinical malaria in children younger than 5 years in Banfora, Burkina Faso...
August 10, 2018: Lancet
Roy Chung, Oussama Wazni, Thomas Dresing, Mina Chung, Walid Saliba, Bruce Lindsay, Patrick Tchou
BACKGROUND: Narrow QRS tachycardia or premature beats (PB) with bystander atrial activation or ventricular-atrial (VA) dissociation is an unusual arrhythmia that can present diagnostic and therapeutic challenges. When VA conduction is robust, these arrhythmias can be difficult to distinguish from atrioventricular nodal reentry. OBJECTIVE: To describe the electrophysiology characteristics, diagnostic maneuvers, and treatment of these types arrhythmias in a series of 7 cases...
August 10, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
Lindsay Johnston, Taylor Sawyer, Akira Nishisaki, Travis Whtifill, Anne Ades, Heather French, Kristen Glass, Rita Dadiz, Christie Bruno, Orly Levit, Sandeep Gangadharan, Daniel Scherzer, Ahmed Moussa, Marc Auerbach
BACKGROUND: Neonatal tracheal intubation (NTI) is an important clinical skill. Suboptimal performance is associated with patient harm. Simulation training can improve NTI performance. Improving performance requires an objective assessment of competency. Competency assessment tools need strong evidence of validity. We hypothesized that a NTI competency assessment tool with multi-source validity evidence could be developed, and could be used for formative and summative assessment during simulation-based training...
August 10, 2018: Academic Pediatrics
Nicole A Guitar, Denise M Connelly, Lindsay S Nagamatsu, Joseph B Orange, Susan W Muir-Hunter
Executive function deficit is an indicator of Alzheimer's-type dementia and manifests as disruptions of attentional control, memory, cognitive flexibility, planning, and reasoning, among other cognitive problems. Physical exercise is suggested to have a protective effect on global cognition with aging. However, whether it influences executive function in people living with Alzheimer's-type dementia specifically is unknown. The current systematic review examined the efficacy of physical exercise on executive function performance in community-dwelling older adults living with Alzheimer's-type dementia...
August 10, 2018: Ageing Research Reviews
Rebecca Levin, Josephine Misun Jung, Lindsay Forrey, Jill Glick
Vitamin K refusal and associated sequelae of vitamin K deficiency bleed (VKDB) in the newborn period is becoming a more common occurrence. We present six recent cases from a 4-month period in 2017 of parent refusal of vitamin K and describe the reasons for refusal and the clinical outcomes of these infants. There have been a number of case reports citing the rising incidence of VKDB and the reasons why parents refuse. However, there is a gap in the literature and clinical practice guidelines describing how a physician should approach a refusal in the hospital and in the office, and the need to report a refusal to child welfare...
August 1, 2018: Pediatric Annals
Sridevi Krishnan, Sean H Adams, Lindsay H Allen, Kevin D Laugero, John W Newman, Charles B Stephensen, Dustin J Burnett, Megan Witbracht, Lucas C Welch, Excel S Que, Nancy L Keim
Background: The 2010 Dietary Guidelines for Americans (DGA) recommend nutrient needs be met by increasing fruit, vegetable, and whole-grain intake with the use of low-fat or fat-free dairy products and by reducing sodium, solid fats, and added sugars. However, the DGA, as a dietary pattern, have not been tested in an intervention trial. Objective: The aim of this study was to evaluate the impact of a DGA-based diet compared with a representative typical American diet (TAD) on glucose homeostasis and fasting lipids in individuals at risk of cardiometabolic disease...
August 1, 2018: American Journal of Clinical Nutrition
Tarak Agrebi Moumni Chouari, Karen Lindsay, Ellen Bradshaw, Simon Parson, Lucy Watson, Jamil Ahmed, Alain Curnier
Background: Performing microsurgery requires a breadth and depth of experience that has arguably been reduced as result of diminishing operating exposure. Fresh frozen cadavers provide similar tissue handling to real-time operating; however, the bloodless condition restricts the realism of the simulation. We describe a model to enhance flap surgery simulation, in conjunction with qualitative assessment. Methods: The fresh frozen cadaveric limbs used in this study were acquired by the University...
2018: European Journal of Plastic Surgery
Jean-Charles Doucet, Kathleen A Russell, John Daskalogiannakis, Ana M Mercado, Nicholas Emanuele, Lindsay James, Ronald R Hathaway, Ross E Long
OBJECTIVE: To investigate the effect that alveolar bone grafting (ABG) around 6 years of age has on facial growth by assessing craniofacial growth outcomes. DESIGN: Retrospective cohort study. SETTING: North American cleft centers. PARTICIPANTS: A total of 33 children with complete unilateral cleft lip and palate who were consecutively treated with secondary ABG around 6 years of age were compared to 148 participants from 4 centers with late secondary ABG...
August 13, 2018: Cleft Palate-craniofacial Journal
James C Cripe, Kathryn A Mills, Lindsay K Kuroki, Leping Wan, Andrea R Hagemann, Katherine C Fuh, David G Mutch, Matthew A Powell, Premal H Thaker
OBJECTIVES: Gynecologic oncologists frequently care for patients at the end of life with the aid of palliative care (PC) specialists. Our primary objectives were to identify perceived barriers to integrating specialty PC into gynecologic cancer care. MATERIALS AND METHODS: Members of the Society of Gynecologic Oncology (SGO) were invited to participate in an anonymous online survey. A Likert scale captured perceptions regarding primary and specialty PC, frequent barriers to use of PC, and potential interventions...
August 10, 2018: Gynecologic and Obstetric Investigation
Victor Albert Brugman, Jolyon M Medlock, James G Logan, Anthony J Wilson, Steve W Lindsay, Anthony R Fooks, Peter P C Mertens, Nicholas Johnson, Simon T Carpenter
No abstract text is available yet for this article.
August 11, 2018: Veterinary Record
Jonathon A Ditlev, Lindsay B Case, Michael K Rosen
Biomolecular condensates are two- and three-dimensional compartments in eukaryotic cells that concentrate specific collections of molecules without an encapsulating membrane. Many condensates behave as dynamic liquids and appear to form through liquid-liquid phase separation driven by weak, multivalent interactions between macromolecules. In this review, we discuss current models and data regarding the control of condensate composition and we describe our current understanding of the composition of representative condensates including PML nuclear bodies, P-bodies, stress granules, the nucleolus, and two-dimensional membrane localized LAT and nephrin clusters...
August 9, 2018: Journal of Molecular Biology
Kai Lee Yap, Amy E Knight Johnson, David Fischer, Priscilla Kandikatla, Jacea Deml, Viswateja Nelakuditi, Sara Halbach, George S Jeha, Lindsay C Burrage, Olaf Bodamer, Valeria C Benavides, Andrea M Lewis, Sian Ellard, Pratik Shah, Declan Cody, Alejandro Diaz, Aishwarya Devarajan, Lisa Truong, Siri Atma W Greeley, Diva D De Leon, Andrew C Edmondson, Soma Das, Paul Thornton, Darrel Waggoner, Daniela Del Gaudio
The author Diva D. De Leon was incorrectly listed as instead of Diva D. De Leó-Critchlow in the original version of this paper.
August 11, 2018: Genetics in Medicine: Official Journal of the American College of Medical Genetics
Lindsay Atherton Edwards, Henri Justino, Shaine A Morris, Jack Rychik, Chris Feudtner, John D Lantos
A 20-week-old fetus was diagnosed with critical pulmonary valve stenosis. Given the ultrasound findings, the outcome was difficult to predict. The fetal cardiologists discussed the possibility of a pulmonary valvuloplasty (an experimental procedure) with the parents, wherein the fetal right ventricle would be punctured with a long 18G needle, and through it, a wire advanced across the pulmonary valve, allowing for balloon dilation of the valve. The experimental procedure had been performed at a handful of centers...
August 10, 2018: Pediatrics
Lindsay R Gabbert, Justin D Smith, John G Neilan, Geoffrey S Ferman, Max V Rasmussen
Validated procedures for decontamination of laboratory surfaces and equipment are essential to biosafety and biorisk programs at high-containment laboratories. Each high-containment laboratory contains a unique combination of surfaces, procedures, and biological agents that require decontamination methods tailored to specific facility practices. The Plum Island Animal Disease Center (PIADC) is a high-containment laboratory operating multiple biosafety level (BSL)-3, ABSL-3, and BSL-3 Ag spaces. The PIADC facility requires the use of federally issued smart cards, called personal identity verification (PIV) cards, to access information technology (IT) networks both outside and within the high-containment laboratory...
August 10, 2018: Health Security
Lindsay Lief, David A Berlin, Renee C Maciejewski, Li Westman, Amanda Su, Zara R Cooper, Daniel J Ouyang, Geraldine Epping, Heather Derry, David Russell, Eliza Gentzler, Paul K Maciejewski, Holly G Prigerson
RATIONALE: Caring for patients at the end of life is emotionally taxing and may contribute to burnout. Nevertheless, little is known about the factors associated with emotional distress in ICU nurses. OBJECTIVE: To identify patient and family factors associated with nurses' emotional distress in caring for dying patients in the intensive care unit (ICU). METHODS: One hundred nurses who cared for 200 deceased ICU patients at two large, academic medical centers in the Northeast United States were interviewed about patients' psychological and physical symptoms, their reactions to those patient experiences (e...
August 10, 2018: Annals of the American Thoracic Society
Lindsay D Lozeau, Sina Youssefian, Nima Rahbar, Terri A Camesano, Marsha W Rolle
Antimicrobial peptides (AMPs) such as LL37 are promising alternatives to antibiotics to treat wound infections due to their broad activity, immunomodulatory functions, and low likelihood of antimicrobial resistance. To deliver LL37 to chronic wounds, we developed two chimeric LL37 peptides with C-terminal collagen binding domains (CBD) derived from collagenase (cCBD-LL37) and fibronectin (fCBD-LL37), as a strategy for noncovalent tethering of LL37 onto collagen-based, commercially available wound dressings...
August 10, 2018: Biomacromolecules
Eloisa Llata, Jim Braxton, Lenore Asbel, Joan Chow, Lindsay Jenkins, Ryan Murphy, Preeti Pathela, Christina Schumacher, Elizabeth Torrone
OBJECTIVE: To examine the prevalence and treatment of rectal Chlamydia trachomatis and Neisseria gonorrhoeae infections among women reporting receptive anal intercourse in a network of sexually transmitted disease or sexual health clinics and estimate the proportion of missed infections if women were tested at the genital site only. METHODS: We conducted a cross-sectional analysis of C trachomatis and N gonorrhoeae test results from female patients reporting receptive anal intercourse in the preceding 3 months during visits to 24 sexually transmitted disease clinics from 2015 to 2016...
August 6, 2018: Obstetrics and Gynecology
Alexandra R Tabachnick, Emilio A Valadez, Erin N Palmwood, Lindsay Zajac, Robert F Simons, Mary Dozier
Early adversity such as maltreatment is associated with increased risk for psychopathology and atypical neurological development in children. The present study examined associations between depressive symptoms and error-related brain activity (the error-related negativity, or ERN) among children involved with Child Protective Services (CPS) and among comparison children. Results indicate that the relation between depressive symptoms and ERN amplitude depends on CPS involvement, such that depressive symptoms were associated with blunted ERNs only for CPS-referred children...
August 10, 2018: Psychophysiology
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