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Synthesis of curcumin

Mahsa Souri, Vahid Hoseinpour, Alireza Shakeri, Nasser Ghaemi
This study concerns the optimisation of green synthesis of manganese oxide nanoparticles (MnO NPs) with Dittrichia graveolens (L.) extract via response surface methodology (RSM). Central composite design was used to evaluate the effect of pH, time, and the extract to the metal ratio on the synthesised nanoparticles (NPs). Nine runs were designed to investigate the effect of each parameter while NPs were synthesised under different conditions. Considering the p -values ( p -value < 0.05), it is indicated that the extract to the metal ratio was the most effective parameter...
September 2018: IET Nanobiotechnology
Kenneth K Laali, William J Greves, Angela T Zwarycz, Sebastian J Correa Smits, Frederick J Troendle, Gabriela L Borosky, Sharoon Akhtar, Alak Manna, Aneel Paulus, Asher Chanan-Khan, Manabu Nukaya, Gregory D Kennedy
In a continuing search for curcuminoid (CUR) compounds with antitumor activity, a novel series of heterocyclic CUR-BF2 adducts and CUR compounds based on indole, benzothiophene, and benzofuran along with their aryl pyrazoles were synthesized. Computational docking studies were performed to compare binding efficiency to target proteins involved in specific cancers, namely HER2, proteasome, VEGFR, BRAF, and Bcl-2, versus known inhibitor drugs. The majority presented very good binding affinities, similar to, and even more favorable than those of known inhibitors...
August 5, 2018: ChemMedChem
Gejo George, Suja Bhargavan Sisupal, Teenu Tomy, Alaganandam Kumaran, Prabha Vadivelu, Vemparthan Suvekbala, Swaminathan Sivaram, Lakshminarayanan Ragupathy
The success of developing graphene based biomaterials depends on its ease of synthesis, use of environmentally benign methods and low toxicity of the chemicals involved as well as biocompatibility of the final products/devices. We report, herein, a simple, scalable and safe method to produce defect free few layers graphene using naturally available phenolics i.e. curcumin/tetrahydrocurcumin/quercetin, as solid-phase exfoliating agents with a productivity of ∼45 g/batch (D/G ≤ 0.54 and D/D' ≤ 1...
July 25, 2018: Scientific Reports
Stephen Bigelsen
Despite new and exciting research and renewed optimism about future therapy, current statistics of survival from pancreatic cancer remains dismal. Patients seeking alternative or complementary treatments should be warned to avoid the hype and instead look to real science. A variety of relatively safe and inexpensive treatment options that have shown success in preclinical models and/or retrospective studies are currently available. Patients require their physicians to provide therapeutic guidance and assistance in obtaining and administrating these various therapies...
2018: Cancer Management and Research
Jie Quan Wang, Xiaobin Wang, Yang Wang, Wen Jian Tang, Jing Bo Shi, Xin Hua Liu
In this study, twenty curcumin analogue hybrids as potential anticancer agents through regulation protein of TrxR were designed and synthesized. Results of anticancer activity showed that 5,7-dimethoxy-3-(3-(2-((1E, 4E)-3-oxo-5-(pyridin-2-yl)penta-1,4-dien-1- yl)phenoxy)propoxy)-2-(3,4,5-trimethoxyphenyl)-4H-chromen-4-one (compound 7d) could induce gastric cancer cells apoptosis by arresting cell cycle, break mitochondria function and inhibit TrxR activity. Meanwhile, western blot revealed that this compound could dramatically up expression of Bax/Bcl-2 ratio and high expression of TrxR oxidation...
July 10, 2018: European Journal of Medicinal Chemistry
Puneet Khandelwal, Aftab Alam, Arpankumar Choksi, Samit Chattopadhyay, Pankaj Poddar
Gold nanoparticles (Au NPs) have been thoroughly investigated for anti-cancer therapy. However, their undesired high gold content remains a problem when injected into the body for drug delivery applications. In this report, we made an effort to conjugate the curcumin molecules on the surface of gold quantum clusters (Au QCs) by a novel in situ synthesis method which provides an alternative route to not only reduce the metallic content but also increase the water solubility of curcumin and the loading efficiency...
May 31, 2018: ACS Omega
Amanda N Abraham, Tarun K Sharma, Vipul Bansal, Ravi Shukla
The rapid formation of the protein corona on to the nanoparticle (NP) surface is the key that confers biological identity to NPs and subsequently dictates their fate both in vitro and in vivo. Despite significant efforts, the inability to control the spontaneous interaction of serum proteins with the administered NPs remains a major constraint in clinical translation of nanomedicines. The ligands present on the NP surface offer promise in controlling their biological interactions; however, their influence on the NP-protein interaction is not well-understood...
February 28, 2018: ACS Omega
Tathagata Pal, Shanid Mohiyuddin, Gopinath Packirisamy
Early detection is the critical phase in the prognostic strategy of various life-threatening maladies like infectious diseases and cancer. The mortality rate caused by these diseases could be considerably reduced if they were diagnosed in the early stages of disease development. Carbon dots (C-dots), a relatively new and promising candidate in the fluorescent nanomaterial category, possess a perceptible impact on various bioapplications. Herein, we report a one-step facile hydrothermal synthesis that yields a novel surface-passivated carbon dot (CDP) from curcumin (as a green substrate) displaying high aqueous solubility...
January 31, 2018: ACS Omega
Eneko Larrañeta, Mikel Imízcoz, Jie X Toh, Nicola J Irwin, Anastasia Ripolin, Anastasia Perminova, Juan Domínguez-Robles, Alejandro Rodríguez, Ryan F Donnelly
Lignin is the second most abundant biopolymer on the planet. It is a biocompatible, cheap, environmentally friendly and readily accessible material. It has been reported that these biomacromolecules have antimicrobial activities. Consequently, lignin (LIG) has the potential to be used for biomedical applications. In the present work, a simple method to prepare lignin-based hydrogels is described. The hydrogels were prepared by combining LIG with poly(ethylene glycol) and poly(methyl vinyl ether- co -maleic acid) through an esterification reaction...
July 2, 2018: ACS Sustainable Chemistry & Engineering
Miri Lee, Kyoung-Sook Kim, Abekura Fukushi, Dong-Hyun Kim, Cheorl-Ho Kim, Young-Choon Lee
Curcumin, a natural polyphenolic compound isolated from the plant Curcuma longa , is known to induce autophagy in various cancer cells, including lung cancer. In the present study, we also confirmed by LC3 immunofluorescence and immunoblotting analyses that curcumin triggers autophagy in the human lung adenocarcinoma A549 cell line. In parallel with autophagy induction, the gene expression of human GD3 synthase (hST8Sia I) responsible for ganglioside GD3 synthesis was markedly elevated in response to curcumin in the A549 cells...
July 2, 2018: International Journal of Molecular Sciences
Raymond E Borg, Maryam Hatamimoslehabadi, Stephanie Bellinger, Jeffrey La, Farha Mithila, Chandra Yelleswarapu, Jonathan Rochford
The synthesis, photophysical and photoacoustic characterization for a series of nine π-extended quadrupolar curcumin dyes is presented. A systematic evaluation of the π-bridging unit including the p-phenyl, naphth-4-yl, thien-2-yl and hybrid 4-naphthathien-2-yl groups is presented. Furthermore, evaluation of the strongly donating donor-π-acceptor-π-donor quadrupolar dimethylamino terminated derivatives is also included. Select dyes exhibit excited state absorption at increased laser fluence which translates to production of a nonlinear enhanced photoacoustic response...
July 10, 2018: Photochemistry and Photobiology
Bharani Meka, Suryachandra Rao Ravada, Murali Krishna Kumar Muthyala, Purna Nagasree Kurre, Trimurtulu Golakoti
A new series of diaryl heptanones (12a-q) were synthesized and their structures were confirmed by its 1 H, 13 C NMR and Mass spectral data. These analogs were evaluated for their anti-oxidant activity and potential to inhibit 5-lipoxygenase. Compounds 12k and 12o showed potent in vitro 5-lipoxygenase enzyme inhibitory activity with IC50 values of 22.2, 21.5 μM, which are comparable to curcumin (24.4 μM). Further they also have shown significant antioxidant activity. Molecular docking studies clearly showed correlation between binding energy and potency of these compounds...
October 2018: Bioorganic Chemistry
Jin-Wun Chen, Zwe-Ling Kong, Mei-Ling Tsai, Chih-Yu Lo, Chi-Tang Ho, Ching-Shu Lai
Elevated levels of free fatty acids (FFAs) in the liver, resulting from either increased lipolysis or imbalanced FFAs flux, is a key pathogenic factor of hepatic steatosis. This study was conducted to examine the therapeutic effect of tetrahydrocurcumin (THC), a naturally occurring curcuminoid and a metabolite of curcumin, on oleic acid (OA)-induced steatosis in human hepatocellular carcinoma cells and to elucidate the underlying mechanism. HepG2 cells were incubated with OA to induce steatosis, and then treated with various concentrations of THC...
July 2018: Journal of Food and Drug Analysis
Zahra Naderi, Javad Azizian
This paper presents the preparation of hydrogel with magnetic properties derived from carboxymethyl chitosan for controlled drug release performance. The magnetic Fe3 O4 and MnFe2 O4 nanoparticles with crosslinked Carboxymethyl Chitosan hydrogel were prepared by using epichlorohydrin as the cross-linker. The structure characterization performed by FT-IR. The XRD analysis was applied for evaluation of crystalline phase of MnFe2 O4 and Fe3 O4 in the hydrogels. The crystallite size of Fe3 O4 /CMCS and MnFe2 O4 /CMCS was calculated to be 30...
August 2018: Journal of Photochemistry and Photobiology. B, Biology
Manoj K Shrivash, Sonali Mishra, UpmaNarain, Jyoti Pandey, Krishna Misra
In the present work two key regulator proteins, monomeric MipZ of Caulobacter vibrioides (similar to Pseudomonas aeruginosa) and Pyruvate kinase of Staphylococcus aureus were docked with curcumin, the wonder molecule from the spice turmeric and structures of its twelve analogues were designed, synthesized and tested in-vitro for antibacterial activity. Based on the test results a comparative account of the probable mechanism has been given Two major alternative targets are possible for antibacterial activity of drug molecules...
June 27, 2018: Microbial Pathogenesis
Yueming Yu, Shaohua Zou, Kaili Wang, Rongcai Liang, Xinxin Fan, Bingjie Wang, Mengna Liu, Lei Fang, Wanhui Liu, Zimei Wu, Daquan Chen
In order to improve the anti-cancer therapy efficiency of hydrophobic drugs such as curcumin (Cur), a novel dual pH/redox sensitive marine laminarin-based nanomedicine carrier biomaterial with photo-dynamic therapy (PDT) was synthesized in this study. The new synthetic chemical structure, named as Hematin-Laminarin-Dithiodipropionic Acid-MGK (HLDM), was characterized by 1H-NMR and IR. The Cur-loaded micelles were then prepared via dialysis method. The HLDM could self-assemble into micelles in water with hydrodynamic diameter of 135±15 nm...
September 1, 2018: Journal of Biomedical Nanotechnology
Mozhgan Aghajanzadeh, Mostafa Zamani, Hamid Rashidzadeh, Kobra Rostamizadeh, Ali Sharafi, Hossein Danafar
In this project, a core-shell Polymersome based on miktoarm star-copolymer: methoxy Poly Ethylene Glycol-Lysine-(Poly Caprolactone)2 (PEG-Lys-PCL2 ) was synthesized by a new method as controlled targeted drug delivery systems for co-delivery of the chemotherapeutic methotrexate (MTX) and curcumin (CUR). Some properties of these nano carriers (NCs) such as surface morphology, structure, surface charge, stability and biocompatibility were evaluated by Proton nuclear magnetic resonance (1 HNMR), dynamic scanning colorimetry (DSC), Fourier-transform infrared spectroscopy (FT-IR), Dynamic light scattering (DLS), atomic force microscopy (AFM), Critical aggregation concentration (CAC), hemolysis test, MTT assay and lethal dose 50 (LD50)...
June 16, 2018: Journal of Biomedical Materials Research. Part A
Li Zhang, Xian Cheng, Shichen Xu, Jiandong Bao, Huixin Yu
BACKGROUND: Thyroid cancer is the most common endocrine tumor. Our previous studies have demonstrated that curcumin can induce apoptosis in human papillary thyroid carcinoma BCPAP cells. However, the underlined mechanism has not been clearly elucidated. Endoplasmic reticulum (ER) is a major organelle for synthesis, maturation, and folding proteins as well as a large store for Ca. Overcoming chronically activated ER stress by triggering pro-apoptotic pathways of the unfolded protein response (UPR) is a novel strategy for cancer therapeutics...
June 2018: Medicine (Baltimore)
Rita M Borik, Nagwa M Fawzy, Sherifa M Abu-Bakr, Magdy S Aly
Curcumin, a widely utilized flavor and coloring agent in food, has been shown to demonstrate powerful antioxidant, antitumor promoting and anti-inflammatory properties in vitro and in vivo. In the present work, synthesis of new heterocyclic derivatives based on Curcumin was studied. Compound 3 was synthesized via the reaction of furochromone carbaldehyde ( 1 ) with Curcumin ( 2 ) using pipredine as catalyst. Also, novel, 4,9-dimethoxy-5 H -furo [3, 2- g ] chromen-5-one derivatives 4a ⁻ d , 6a ⁻ d , 7 , 8a ⁻ d , 9 and 10 were synthesized by the reactions of furochromone carbaldehyde ( 1 ) with different reagents (namely: appropriate amine 3a ⁻ d , appropriate hydrazine 5a ⁻ d , hydroxylamine hydrochloride, urea/thiourea, malononitrile, malononitrile with hydrazine hydrate)...
June 8, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Wenjie Zhang, Heyuan Bai, Liqiang Han, Han Zhang, Bo Xu, Jingrong Cui, Xin Wang, Zemei Ge, Runtao Li
Curcumin is a well-known pharmacophore and some of its derivatives are shown to target 20S proteasome recently. In this report, we designed and synthesized two series of curcumin derivatives modified with different α-amino boronic acids as potent proteasome inhibitors. The synthesized compounds were evaluated for their cytotoxic activities against HCT116 cells, and the results showed that all of them exhibited excellent cell growth inhibitory activity comparing with curcumin, with the IC50 values varying from 0...
August 1, 2018: Bioorganic & Medicinal Chemistry Letters
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