Junghee Jenny Shin, Jennefer Par-Young, Serhan Unlu, Andrew McNamara, Hong-Jai Park, Min Sun Shin, Renelle J Gee, Hester Doyle, Yuliya Afinogenova, Elena Zidan, Jason Kwah, Armand Russo, Mark Mamula, Florence Ida Hsu, Jason Catanzaro, Michael Racke, Richard Bucala, Craig Wilen, Insoo Kang
Immune responses to coronavirus disease 2019 (COVID-19) mRNA vaccines in primary antibody deficiencies (PADs) are largely unknown. We investigated antibody and CD4+ T-cell responses specific for SARS-CoV-2 spike protein (S) before and after vaccination and associations between vaccine response and patients' clinical and immunological characteristics in PADs. The PAD cohort consisted of common variable immune deficiency (CVID) and other PADs, not meeting the criteria for CVID diagnosis (oPADs). Anti-S IgG, IgA, and IgG subclasses 1 and 3 increased after vaccination and correlated with neutralization activity in HCs and patients with oPADs...
June 17, 2022: Journal of Clinical Immunology