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Acute chorioamnionitis

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https://www.readbyqxmd.com/read/30334666/spectrum-of-changes-seen-with-placental-intravascular-organisms
#1
Pawel T Schubert, Deidre Mason, Roosacelis Martines, Marlene Deleon-Carnes, Sherif R Zaki, Drucilla J Roberts
Fetal bacterial infections are a common cause of fetal/neonatal morbidity and mortality. The pathologic correlates of congenital bacterial infection include acute chorioamnionitis, acute villitis, and acute intervillositis. The strength of the association of congenital bacterial infection differs among these pathologies. Acute chorioamnionitis results usually from an ascending infection, and damage to the fetus is thought to be cytokine driven rather than damage secondary to bacteremia. Acute villitis is strongly associated with fetal sepsis due to congenital infections...
October 18, 2018: Pediatric and Developmental Pathology
https://www.readbyqxmd.com/read/30314768/prenatal-intra-amniotic-endotoxin-induces-fetal-gut-and-lung-immune-responses-and-postnatal-systemic-inflammation-in-preterm-pigs
#2
Duc Ninh Nguyen, Thomas Thymann, Sandra K Goericke-Pesch, Shuqiang Ren, Wei Wei, Kerstin Skovgaard, Peter Damborg, Anders Brunse, Charlotte van Gorp, Boris W Kramer, Tim G Wolfs, Per T Sangild
Prenatal inflammation is a major risk for preterm birth and neonatal morbidity, but its effects on postnatal immunity and organ functions remain unclear. Using preterm pigs as a model for preterm infants, we investigated whether prenatal intra-amniotic (IA) inflammation modulates postnatal systemic immune status and organ functions. Preterm pigs exposed to IA lipopolysaccharide (LPS) for 3 days were compared with controls at birth and postnatal day 5 after formula feeding. IA LPS induced mild chorioamnionitis but extensive intra-amniotic inflammation...
October 4, 2018: American Journal of Pathology
https://www.readbyqxmd.com/read/30141444/efficacy-and-safety-of-intravaginal-misoprostol-for-mid-trimester-medical-termination-of-pregnancy
#3
S Yousuf, N Akhter, S Arzoo, B Ferdous
Misoprostol has been widely used in Obstetrics and Gynecology for cervical priming, medical abortion and induction of labour. The purpose of the present study was to evaluate the efficacy and safety of intravaginal misoprostol in mid-trimester medical termination of pregnancy. This non-randomized clinical trial was carried out in the Department of Obstetrics and Gynecology at Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh from July 2007 to June 2008 for a period of one year. Primi- or multigravid women with 13 to 28 weeks of singleton pregnancy, fetal congenital malformation and missed abortion who were selected for medical termination of pregnancy were included in this study...
July 2018: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/30128872/maternal-murine-cytomegalovirus-infection-during-pregnancy-up-regulates-the-gene-expression-of-toll-like-receptor-2-and-4-in-placenta
#4
Yi Liao, Ya-Nan Zhang, Xing-Lou Liu, Yuan-Yuan Lu, Lin-Lin Zhang, Ting Xi, Sai-Nan Shu, Feng Fang
Increasing evidence has revealed that maternal cytomegalovirus (CMV) infection may be associated with neurodevelopmental disorders in offspring. Potential relevance between the placental inflammation and CMV-related autism has been reported by clinical observation. Meanwhile, abnormal expression of Toll-like receptor 2 (TLR2) and TLR4 in placenta of patients with chorioamnionitis was observed in multiple studies. IL-6 and IL-10 are two important maternal inflammatory mediators involved in neurodevelopmental disorders...
August 2018: Current medical science
https://www.readbyqxmd.com/read/30021565/impact-of-obesity-and-other-risk-factors-on-labor-dystocia-in-term-primiparous-women-a-case-control-study
#5
Tuija Hautakangas, Outi Palomäki, Karoliina Eidstø, Heini Huhtala, Jukka Uotila
BACKGROUND: Purpose of this study was to investigate differences between primiparous term pregnancies, one leading to vaginal delivery (VD) and the other to acute cesarean section (CS) due to labor dystocia in the first stage of labor. We particularly wanted to assess the influence of body mass index (BMI) on CS risk. METHODS: A retrospective case-control study in a tertiary delivery unit with 5200 deliveries annually. Cases were 296 term primiparous women whose intended vaginal labor ended in acute CS because of dystocia...
July 18, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29908375/the-change-of-fetal-heart-rate-short-term-variability-during-the-course-of-histological-chorioamnionitis-in-fetal-sheep
#6
Hyo Kyozuka, Syun Yasuda, Tsuyoshi Hiraiwa, Yasuhisa Nomura, Keiya Fujimori
OBJECTIVE: Histological chorioamnionitis (CAM) is related to neonatal mortality and morbidity. However, identifying intrauterine inflammation before delivery is challenging. The aim of this study was to investigate the changes in fetal heart rate (FHR) short-term variability (STV) during the course of histological CAM. STUDY DESIGN: Changes in STV were measured in 7 chronically instrumented fetal sheep at 111-120 days of gestation. Lipopolysaccharide (LPS) was infused into the amniotic cavity for 2 days following the 4th postoperative day to develop histological CAM...
September 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29880186/successful-treatment-of-maternal-listeria-monocytogenes-bacteremia-in-the-first-trimester-of-pregnancy-a-case-report-and-literature-review
#7
Lai-Man Chan, Ho-Hsiung Lin, Sheng-Mou Hsiao
OBJECTIVE: To report detailed clinical history and management of maternal listeria infection in the first trimester. CASE REPORT: A 34-year-old woman at 11 gestational weeks was infected by Listeria monocytogenes with clinical symptoms of acute onset of a fever with subsequent headache and neck stiffness, and was treated with intravenous ampicillin at 2 g every 4 h for 3 weeks. A healthy, unaffected male baby was delivered at term. Histopathologic examination of the placenta did not reveal any chorioamnionitis, granulomas, microabscesses or vasculitis...
June 2018: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29804839/persistent-methicillin-resistant-staphylococcus-aureus-bacteremia-owing-to-placental-abscess
#8
Naomi Maeda, Hideharu Hagiya, Tsuyoshi Takiuchi, Shinsuke Kusakabe, Tetsuo Maeda, Keigo Kimura, Sayuri Iwai, Keisuke Kawasaki, Yumiko Hori, Eiichi Morii, Yuzuru Kanakura, Tadashi Kimura, Kazunori Tomono
Staphylococcus aureus as a pathogen in human gestational membranes, a rather rare phenomenon, has recently been the focus of several researches. S. aureus forms biofilms on these membranes and potentially causes chorioamnionitis in pregnant women. We report a case of persistent methicillin-resistant S. aureus (MRSA) bacteremia owing to placental infection, causing chorioamnionitis and preterm birth. A 29-year-old Japanese woman at the 27th gestational week was diagnosed with acute promyelocytic leukemia and underwent all-trans retinoic acid therapy...
May 24, 2018: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/29453682/persistent-pulmonary-hypertension-and-histologic-chorioamnionitis-in-preterm-infants-controlled-study
#9
N Katz, Y Bar-Or, A Raucher-Sterrnfeld, A Tamir, D Kohelet
Persistent pulmonary hypertension (PPHN) of the newborn is one of the most challenging acute disorders of postnatal transition with substantial morbidity and mortality. The aim of the study was to find if there is an association between persistent pulmonary hypertension and histologic chorioamnionitis in preterm infants. 27 preterm infants with echocardiographic evidence of PPHN within the first 3 days of life were eligible for the study. A matched control group of 27 patients was chosen according to gestational age, date of birth, and gender...
April 2018: Pediatric Cardiology
https://www.readbyqxmd.com/read/29381706/ocular-and-uteroplacental-pathology-in-a-macaque-pregnancy-with-congenital-zika-virus-infection
#10
Emma L Mohr, Lindsey N Block, Christina M Newman, Laurel M Stewart, Michelle Koenig, Matthew Semler, Meghan E Breitbach, Leandro B C Teixeira, Xiankun Zeng, Andrea M Weiler, Gabrielle L Barry, Troy H Thoong, Gregory J Wiepz, Dawn M Dudley, Heather A Simmons, Andres Mejia, Terry K Morgan, M Shahriar Salamat, Sarah Kohn, Kathleen M Antony, Matthew T Aliota, Mariel S Mohns, Jennifer M Hayes, Nancy Schultz-Darken, Michele L Schotzko, Eric Peterson, Saverio Capuano, Jorge E Osorio, Shelby L O'Connor, Thomas C Friedrich, David H O'Connor, Thaddeus G Golos
Congenital Zika virus (ZIKV) infection impacts fetal development and pregnancy outcomes. We infected a pregnant rhesus macaque with a Puerto Rican ZIKV isolate in the first trimester. The pregnancy was complicated by preterm premature rupture of membranes (PPROM), intraamniotic bacterial infection and fetal demise 49 days post infection (gestational day 95). Significant pathology at the maternal-fetal interface included acute chorioamnionitis, placental infarcts, and leukocytoclastic vasculitis of the myometrial radial arteries...
2018: PloS One
https://www.readbyqxmd.com/read/29328041/von-willebrand-factor-immunohistochemical-staining-quantitative-optical-density-parameters-in-the-endothelium-and-fibrinoid-of-the-placenta-during-secundines-inflammation-and-concomitant-iron-deficiency-anemia-in-gravidas
#11
V Ilika, I Davydenko
The aim of the research was to set the optical density quantitative parameters of the von Willebrand factor immunohistochemical staining (vWF) in the endothelium and fibrinoid of the placenta during the secundines inflammation concomitant with iron deficiency anemia in gravidas. The total number of 198 placentas was studied. The immunohistochemical technique was performed using the visualization of the primary antibodies to vWF with a diaminobenzidine dye polymer system. The optical density of the histochemical staining was measured by means of computer microdensitometry after the digital copies of the images had been obtained...
December 2017: Georgian Medical News
https://www.readbyqxmd.com/read/29193660/preterm-birth-with-placental-evidence-of-malperfusion-is-associated-with-cardiovascular-risk-factors-after-pregnancy-a-prospective-cohort-study
#12
J M Catov, M F Muldoon, S E Reis, R B Ness, L N Nguyen, J-M Yamal, H Hwang, W T Parks
OBJECTIVE: Preterm birth (PTB) is associated with excess maternal cardiovascular disease risk. We considered that women with PTB and placental evidence of maternal malperfusion would be particularly affected. DESIGN: Pregnancy cohort study. SETTING: Pittsburgh, PA, USA. POPULATION: Women with PTB (n = 115) and term births (n = 210) evaluated 4-12 years after pregnancy. METHODS: Cardiometabolic risk markers were compared in women with prior PTB versus term births; pre-eclampsia and growth restriction cases were excluded...
July 2018: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29155162/chorioamnionitis-due-to-leptotrichia-trevisanii
#13
Dionisia Fontanals, Carlos García-Miralles, Rosa Ballester, Belen Cochs, Ruth Orellana, Sílvia Capilla
Very long fusiform gram-negative bacilli were observed after Gram staining of amniotic fluid from a 36-year-old multigravida woman. At 24 hours, pure, abundant growth of smooth, gray, only slightly convex catalase-positive and oxidase-negative colonies measuring about 2 mm were observed. Growth was greater in anaerobic than in aerobic conditions. The bacterium was identified as Leptotrichia trevisanii by matrix-assisted laser desorption ionization time of flight mass spectrometry. Ampicillin and gentamicin were prescribed for chorioamnionitis, and vaginal prostaglandins were administered to terminate the pregnancy...
February 2018: Anaerobe
https://www.readbyqxmd.com/read/29138035/defining-failed-induction-of-labor
#14
MULTICENTER STUDY
William A Grobman, Jennifer Bailit, Yinglei Lai, Uma M Reddy, Ronald J Wapner, Michael W Varner, John M Thorp, Kenneth J Leveno, Steve N Caritis, Mona Prasad, Alan T N Tita, George Saade, Yoram Sorokin, Dwight J Rouse, Sean C Blackwell, Jorge E Tolosa
BACKGROUND: While there are well-accepted standards for the diagnosis of arrested active-phase labor, the definition of a "failed" induction of labor remains less certain. One approach to diagnosing a failed induction is based on the duration of the latent phase. However, a standard for the minimum duration that the latent phase of a labor induction should continue, absent acute maternal or fetal indications for cesarean delivery, remains lacking. OBJECTIVE: The objective of this study was to determine the frequency of adverse maternal and perinatal outcomes as a function of the duration of the latent phase among nulliparous women undergoing labor induction...
January 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29113335/maternal-and-fetal-outcomes-of-pregnant-women-with-type-1-diabetes-a-national-population-study
#15
Shu-Fu Lin, Chang-Fu Kuo, Meng-Jiun Chiou, Shang-Hung Chang
Pregnancy in women with type 1 diabetes is associated with poor maternal and neonatal outcomes. However, the risk of these outcomes has never been evaluated in an Asian national population. In this work, we report the maternal and fetal outcomes of pregnant women with type 1 diabetes in Taiwan. A total of 2,350,339 pregnancy records created between 2001 and 2012 were obtained from the National Health Insurance database and analyzed. Here, 630 pregnancy records were identified in women having type 1 diabetes...
October 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/29083107/increased-mir-223-expression-in-foetal-organs-is-a-signature-of-acute-chorioamnionitis-with-systemic-consequences
#16
JoonHo Lee, Chong Jai Kim, Jung-Sun Kim, Deug-Chan Lee, Sejin Ahn, Bo Hyun Yoon
Acute chorioamnionitis, frequently observed in preterm placentas, is a major risk factor for the development of infection and non-infection-related adverse perinatal outcomes. MicroRNAs play important roles in immune cell development and function as well as in the development of cancers and neurologic diseases. We sought to investigate the changes in microRNA-223 (miR-223) expression and the functional significance of the changes in miR-223 expression in foetal organs in the presence of acute chorioamnionitis...
February 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29060962/-clinical-analysis-of-19-pregnancies-complicated-listeriosis
#17
L H Kuang, Y H Gong, M Su, Y M Jiang
Objective: To analyze the clinical characteristics and perinatal outcomes of listeriosis during pregnancy. Methods: From July 2010 to April 2017, 70 131 women delivered in West China Second University Hospital. Nineteen cases were confirmed as listeriosis. The clinical symptoms, laboratory results, pathogens, placenta pathology and perinatal outcomes were analyzed retrospectively. Results: The median age of the 19 cases was 29.7 (19.0-42.0) years old. The median time before diagnosis was 4.8(0.5-19.0) days...
October 25, 2017: Zhonghua Fu Chan Ke za Zhi
https://www.readbyqxmd.com/read/28971254/placental-pathology-varies-in-hypertensive-conditions-of-pregnancy
#18
Jerzy Stanek
This study was a comprehensive analysis of placental phenotypes in hypertensive conditions of pregnancy, including recently described placental hypoxic lesions and lesions of shallow placentation. To this end, consecutive placentas from > 21 weeks pregnancies that were signed out by the author at 4 tertiary care centers on 3 continents were included. Twenty-four clinical and 50 placental phenotypes were studied in 6 groups and statistically compared: 91 cases of gestational hypertension, 187 cases of mild preeclampsia, 211 cases of severe preeclampsia, 84 cases of HELLP or eclampsia, 127 cases of chronic hypertension, and 55 cases of preeclampsia superimposed on chronic hypertension...
March 2018: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28950234/effects-of-the-early-administration-of-sivelestat-sodium-on-bronchopulmonary-dysplasia-in-infants-a-retrospective-cohort-study
#19
Ryo Ogawa, Rintaro Mori, Koichi Iida, Yumiko Uchida, Makoto Oshiro, Misao Kageyama, Yuichi Kato, Taihei Tanaka, Yusei Nakata, Yutaka Nishimura, Isamu Hokuto, Motoki Bonno, Naoko Matsumoto, Masato Ito, Noriko Takahashi, Fumihiko Namba
BACKGROUND: Chorioamnionitis, or infiltration of the chorioamnion by neutrophils, is a risk factor associated with the development of bronchopulmonary dysplasia. Increased neutrophil elastase levels are observed in the tracheal aspirates of these patients. AIMS: To examine the effects of early administration of the selective neutrophil elastase inhibitor sivelestat, which is used to treat acute lung injury in adults, on bronchopulmonary dysplasia in extremely premature infants...
December 2017: Early Human Development
https://www.readbyqxmd.com/read/28847437/preterm-labor-in-the-absence-of-acute-histologic-chorioamnionitis-is-characterized-by-cellular-senescence-of-the-chorioamniotic-membranes
#20
Nardhy Gomez-Lopez, Roberto Romero, Olesya Plazyo, George Schwenkel, Valeria Garcia-Flores, Ronald Unkel, Yi Xu, Yaozhu Leng, Sonia S Hassan, Bogdan Panaitescu, Jeeyeon Cha, Sudhansu K Dey
BACKGROUND: Decidual senescence has been considered a mechanism of disease for spontaneous preterm labor in the absence of severe acute inflammation. Yet, signs of cellular senescence have also been observed in the chorioamniotic membranes from women who underwent the physiological process of labor at term. OBJECTIVE: We aimed to investigate whether, in the absence of acute histologic chorioamnionitis, the chorioamniotic membranes from women who underwent spontaneous preterm labor or labor at term exhibit signs of cellular senescence...
November 2017: American Journal of Obstetrics and Gynecology
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