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https://www.readbyqxmd.com/read/29412514/effects-of-parent-implemented-early-start-denver-model-intervention-on-chinese-toddlers-with-autism-spectrum-disorder-a-non-randomized-controlled-trial
#1
Bingrui Zhou, Qiong Xu, Huiping Li, Ying Zhang, Yi Wang, Sally J Rogers, Xiu Xu
To evaluate the effects of a 26-week, high-intensity, parent-implemented Early Start Denver Model (P-ESDM) intervention on developmental outcomes, severity of autism spectrum disorder (ASD), and parental stress of ASD toddlers in China. Subjects in P-ESDM group (n = 23) were recruited from 1.5- to 2.5-year-old toddlers who were screened positive in Xuhui and Minhang Districts and were diagnosed with ASD. A community (comparison) group of age-matched toddlers with ASD (n = 20) was recruited from other areas...
April 2018: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/28838582/cost-offset-associated-with-early-start-denver-model-for-children-with-autism
#2
RANDOMIZED CONTROLLED TRIAL
Zuleyha Cidav, Jeff Munson, Annette Estes, Geraldine Dawson, Sally Rogers, David Mandell
OBJECTIVE: To determine the effect of the Early Start Denver Model (ESDM) for treatment of young children with autism on health care service use and costs. METHOD: We used data from a randomized trial that tested the efficacy of the ESDM, which is based on developmental and applied behavioral analytic principles and delivered by trained therapists and parents, for 2 years. Parents were interviewed about their children's service use every 6 months from the onset of the intervention to follow-up (age 6 years)...
September 2017: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/28685407/evaluating-the-social-validity-of-the-early-start-denver-model-a-convergent-mixed-methods-study
#3
Emily Ogilvie, Matthew T McCrudden
An intervention has social validity to the extent that it is socially acceptable to participants and stakeholders. This pilot convergent mixed methods study evaluated parents' perceptions of the social validity of the Early Start Denver Model (ESDM), a naturalistic behavioral intervention for children with autism. It focused on whether the parents viewed (a) the ESDM goals as appropriate for their children, (b) the intervention procedures as acceptable and appropriate, and (c) whether changes in their children's behavior was practically significant...
September 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28574476/parameters-for-fabricating-nano-au-colloids-through-the-electric-spark-discharge-method-with-micro-electrical-discharge-machining
#4
Kuo-Hsiung Tseng, Meng-Yun Chung, Chaur-Yang Chang
In this study, the Electric Spark Discharge Method (ESDM) was employed with micro-electrical discharge machining (m-EDM) to create an electric arc that melted two electrodes in deionized water (DW) and fabricated nano-Au colloids through pulse discharges with a controlled on-off duration (TON-TOFF) and a total fabrication time of 1 min. A total of six on-off settings were tested under normal experimental conditions and without the addition of any chemical substances. Ultraviolet-visible spectroscopy (UV-Vis), Zetasizer Nano measurements, and scanning electron microscopy-energy dispersive X-ray (SEM-EDX) analyses suggested that the nano-Au colloid fabricated at 10-10 µs (10 µs on, 10 µs off) had higher concentration and suspension stability than products made at other TON-TOFF settings...
June 2, 2017: Nanomaterials
https://www.readbyqxmd.com/read/28348195/impact-of-the-early-start-denver-model-on-the-cognitive-level-of-children-with-autism-spectrum-disorder-study-protocol-for-a-randomised-controlled-trial-using-a-two-stage-zelen-design
#5
RANDOMIZED CONTROLLED TRIAL
Sandrine Touzet, Pauline Occelli, Carmen Schröder, Sabine Manificat, Ludovic Gicquel, Razvana Stanciu, Marie Schaer, Marie-Joelle Oreve, Mario Speranza, Angelique Denis, Amelie Zelmar, Bruno Falissard, Nicolas Georgieff, Stephane Bahrami, Marie-Maude Geoffray
INTRODUCTION: Early intervention for autism spectrum disorder (ASD) in the European French-speaking countries is heterogeneous and poorly evaluated to date. Early intervention units applying the Early Start Denver Model (ESDM) for toddlers and young children with ASD have been created in France and Belgium to improve this situation. It is essential to evaluate this intervention for the political decision-making process regarding ASD interventions in European French-speaking countries...
March 27, 2017: BMJ Open
https://www.readbyqxmd.com/read/28344643/goliah-gaming-open-library-for-intervention-in-autism-at-home-a-6-month-single-blind-matched-controlled-exploratory-study
#6
Anne-Lise Jouen, Antonio Narzisi, Jean Xavier, Elodie Tilmont, Nicolas Bodeau, Valentina Bono, Nabila Ketem-Premel, Salvatore Anzalone, Koushik Maharatna, Mohamed Chetouani, Filippo Muratori, David Cohen
BACKGROUND: To meet the required hours of intensive intervention for treating children with autism spectrum disorder (ASD), we developed an automated serious gaming platform (11 games) to deliver intervention at home (GOLIAH) by mapping the imitation and joint attention (JA) subset of age-adapted stimuli from the Early Start Denver Model (ESDM) intervention. Here, we report the results of a 6-month matched controlled exploratory study. METHODS: From two specialized clinics, we included 14 children (age range 5-8 years) with ASD and 10 controls matched for gender, age, sites, and treatment as usual (TAU)...
2017: Child and Adolescent Psychiatry and Mental Health
https://www.readbyqxmd.com/read/27366069/early-diagnosis-and-early-start-denver-model-intervention-in-autism-spectrum-disorders-delivered-in-an-italian-public-health-system-service
#7
Raffaella Devescovi, Lorenzo Monasta, Alice Mancini, Maura Bin, Valerio Vellante, Marco Carrozzi, Costanza Colombi
BACKGROUND: Early diagnosis combined with an early intervention program, such as the Early Start Denver Model (ESDM), can positively influence the early natural history of autism spectrum disorders. This study evaluated the effectiveness of an early ESDM-inspired intervention, in a small group of toddlers, delivered at low intensity by the Italian Public Health System. METHODS: Twenty-one toddlers at risk for autism spectrum disorders, aged 20-36 months, received 3 hours/wk of one-to-one ESDM-inspired intervention by trained therapists, combined with parents' and teachers' active engagement in ecological implementation of treatment...
2016: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/27117066/methamphetamine-alters-microglial-immune-function-through-p2x7r-signaling
#8
Nicole C Fernandes, Uma Sriram, Larisa Gofman, Jonathan M Cenna, Servio H Ramirez, Raghava Potula
BACKGROUND: Purinoceptors have emerged as mediators of chronic inflammation and neurodegenerative processes. The ionotropic purinoceptor P2X7 (P2X7R) is known to modulate proinflammatory signaling and integrate neuronal-glial circuits. Evidence of P2X7R involvement in neurodegeneration, chronic pain, and chronic inflammation suggests that purinergic signaling plays a major role in microglial activation during neuroinflammation. In this study, we investigated the effects of methamphetamine (METH) on microglial P2X7R...
April 26, 2016: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/27020055/outcome-for-children-receiving-the-early-start-denver-model-before-and-after-48-months
#9
COMPARATIVE STUDY
Giacomo Vivanti, Cheryl Dissanayake
The Early Start Denver Model (ESDM) is an intervention program recommended for pre-schoolers with autism ages 12-48 months. The rationale for this recommendation is the potential for intervention to affect developmental trajectories during early sensitive periods. We investigated outcomes of 32 children aged 18-48 months and 28 children aged 48-62 months receiving the ESDM for one year (approximately 20 h per week). Younger children achieved superior verbal DQ gains compared to their older counterparts...
July 2016: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/26959607/characterization-of-inflammatory-markers-and-transcriptome-profiles-of-differentially-activated-embryonic-stem-cell-derived-microglia
#10
Eva Beins, Thomas Ulas, Svenja Ternes, Harald Neumann, Joachim L Schultze, Andreas Zimmer
Microglia, the immune cells of the CNS, are highly adaptive cells that can acquire different pro- and anti-inflammatory activation states with distinct functions in CNS homeostasis and pathologies. To study microglial function in vitro, primary microglia or immortalized cell lines are commonly used. An alternative to these cells are embryonic stem cell-derived microglia (ESdM). ESdM have previously been shown to be very similar to primary microglia in terms of expression profiles and surface molecules. In this study, ESdM and primary microglia were treated with different inflammatory stimulants to analyze their ability to adopt different activation states...
June 2016: Glia
https://www.readbyqxmd.com/read/26946194/relative-role-of-akt-erk-and-creb-in-alcohol-induced-microglia-p2x4r-receptor-expression
#11
Larisa Gofman, Nicole C Fernandes, Raghava Potula
AIMS: Previously we have demonstrated altered microglia P2X4R expression in response to alcohol and pharmacological blockade with a selective P2X4R antagonist can reverse the action, suggesting that P2X4R play a role in mediating alcohol-induced effects on microglia. In the present study, we investigated the underlying signaling mediators, which may play a role in modulating P2X4R expression in microglia cells in response to alcohol. METHODS: Embryonic stem cell-derived microglia (ESdM) cells were used to investigate the potential mechanisms involved in the regulation of P2X4R in response to alcohol...
November 2016: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
https://www.readbyqxmd.com/read/26511434/evidence-for-the-implementation-of-the-early-start-denver-model-for-young-children-with-autism-spectrum-disorder
#12
REVIEW
Kayce H Ryberg
BACKGROUND: The Early Start Denver Model (ESDM) is a manualized comprehensive therapy for toddlers with autism spectrum disorder. It emphasizes interpersonal engagement through synchrony, rhythms, and reciprocity to decrease symptom severity and accelerate cognitive, social-emotional, and language development. OBJECTIVE: To systematically review evidence regarding the use of the ESDM as an intervention for young children with autism spectrum disorder. DESIGN: PubMed, Scopus, Web of Science, Embase, and CINAHL were searched from 2010-2015 using predetermined inclusion criteria...
September 2015: Journal of the American Psychiatric Nurses Association
https://www.readbyqxmd.com/read/26088663/long-term-outcomes-of-early-intervention-in-6-year-old-children-with-autism-spectrum-disorder
#13
RANDOMIZED CONTROLLED TRIAL
Annette Estes, Jeffrey Munson, Sally J Rogers, Jessica Greenson, Jamie Winter, Geraldine Dawson
OBJECTIVE: We prospectively examined evidence for the sustained effects of early intervention based on a follow-up study of 39 children with ASD who began participation in a randomized clinical trial testing the effectiveness of the Early Start Denver Model (ESDM) at age 18 to 30 months. The intervention, conducted at a high level of intensity in-home for 2 years, showed evidence of efficacy immediately posttreatment. METHOD: This group of children was assessed at age 6 years, 2 years after the intervention ended, across multiple domains of functioning by clinicians naive to previous intervention group status...
July 2015: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/25936527/cost-effectiveness-analysis-comparing-pre-diagnosis-autism-spectrum-disorder-asd-targeted-intervention-with-ontario-s-autism-intervention-program
#14
COMPARATIVE STUDY
Melanie Penner, Meera Rayar, Naazish Bashir, S Wendy Roberts, Rebecca L Hancock-Howard, Peter C Coyte
Novel management strategies for autism spectrum disorder (ASD) propose providing interventions before diagnosis. We performed a cost-effectiveness analysis comparing the costs and dependency-free life years (DFLYs) generated by pre-diagnosis intensive Early Start Denver Model (ESDM-I); pre-diagnosis parent-delivered ESDM (ESDM-PD); and the Ontario Status Quo (SQ). The analyses took government and societal perspectives to age 65. We assigned probabilities of Independent, Semi-dependent or Dependent living based on projected IQ...
September 2015: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/25928566/activated-microglia-macrophage-whey-acidic-protein-amwap-inhibits-nf%C3%AE%C2%BAb-signaling-and-induces-a-neuroprotective-phenotype-in-microglia
#15
Alexander Aslanidis, Marcus Karlstetter, Rebecca Scholz, Sascha Fauser, Harald Neumann, Cora Fried, Markus Pietsch, Thomas Langmann
BACKGROUND: Microglia reactivity is a hallmark of neurodegenerative diseases. We have previously identified activated microglia/macrophage whey acidic protein (AMWAP) as a counter-regulator of pro-inflammatory response. Here, we studied its mechanisms of action with a focus on toll-like receptor (TLR) and nuclear factor κB (NFκB) signaling. METHODS: Recombinant AMWAP was produced in Escherichia coli and HEK293 EBNA cells and purified by affinity chromatography...
2015: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/25135400/p2x4-receptor-regulates-alcohol-induced-responses-in-microglia
#16
Larisa Gofman, Jonathan M Cenna, Raghava Potula
Mounting evidence indicates that alcohol-induced neuropathology may result from multicellular responses in which microglia cells play a prominent role. Purinergic receptor signaling plays a key role in regulating microglial function and, more importantly, mediates alcohol-induced effects. Our findings demonstrate that alcohol increases expression of P2X4 receptor (P2X4R), which alters the function of microglia, including calcium mobilization, migration and phagocytosis. Our results show a significant up-regulation of P2X4 gene expression as analyzed by real-time qPCR (***p < 0...
December 2014: Journal of Neuroimmune Pharmacology: the Official Journal of the Society on NeuroImmune Pharmacology
https://www.readbyqxmd.com/read/24999471/new-experimental-treatments-for-core-social-domain-in-autism-spectrum-disorders
#17
REVIEW
Roberto Canitano
Current therapeutics in autism spectrum disorders (ASD) only treat the associated symptoms, without addressing core social dysfunctions. A paradigm shift in research of the pathogenesis of ASD, its synaptic abnormalities and altered signaling in multiple dynamic systems, have led to new experimental treatments for treating the core social abnormalities of ASD. NMDA antagonists, especially memantine, have been introduced in clinical trials addressing glutamatergic transmission in children and adolescents with ASD...
2014: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/24974255/effectiveness-and-feasibility-of-the-early-start-denver-model-implemented-in-a-group-based-community-childcare-setting
#18
COMPARATIVE STUDY
Giacomo Vivanti, Jessica Paynter, Ed Duncan, Hannah Fothergill, Cheryl Dissanayake, Sally J Rogers
A recent study documented the efficacy of the Early Start Denver Model (ESDM) delivered in a 1:1 fashion. In the current study we investigated the effectiveness and feasibility of the ESDM in the context of a long-day care community service, with a child-staff ratio of 1:3. Outcomes of 27 preschoolers with ASD undergoing 15-25 h per week of ESDM over 12 months were compared to those of 30 peers with ASD undergoing a different intervention program delivered in a similar community long-day care service. Children in both groups made gains in cognitive, adaptive and social skills...
December 2014: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/24847474/reducing-maladaptive-behaviors-in-preschool-aged-children-with-autism-spectrum-disorder-using-the-early-start-denver-model
#19
Elizabeth Fulton, Valsamma Eapen, Rudi Crnčec, Amelia Walter, Sally Rogers
The presence of maladaptive behaviors in young people with autism spectrum disorder (ASD) can significantly limit engagement in treatment programs, as well as compromise future educational and vocational opportunities. This study aimed to explore whether the Early Start Denver Model (ESDM) treatment approach reduced maladaptive behaviors in preschool-aged children with ASD in a community-based long day care setting. The level of maladaptive behavior of 38 children with ASD was rated using an observation-based measure on three occasions during the intervention: on entry, 12 weeks post-entry, and on exit (post-intervention) over an average treatment duration of 11...
2014: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/23838727/the-impact-of-parent-delivered-intervention-on-parents-of-very-young-children-with-autism
#20
RANDOMIZED CONTROLLED TRIAL
Annette Estes, Laurie Vismara, Carla Mercado, Annette Fitzpatrick, Lauren Elder, Jessica Greenson, Catherine Lord, Jeffrey Munson, Jamie Winter, Gregory Young, Geraldine Dawson, Sally Rogers
This study investigated the impact of a parent-coaching intervention based on the Early Start Denver Model (P-ESDM) on parenting-related stress and sense of competence. This was part of a multisite, randomized trial comparing P-ESDM (n = 49) with community intervention (n = 49) for children aged 12 and 24 months. The P-ESDM group reported no increase in parenting stress, whereas the Community group experienced an increase over the same 3-month period. Parental sense of competence did not differ. Number of negative life events was a significant predictor of parenting stress and sense of competence across both groups...
February 2014: Journal of Autism and Developmental Disorders
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