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Ronak Afshari, Ahmad Shaabani
The emergence of neoteric synthetic routes for materials functionalization is an interesting phenomenon in materials chemistry. In particular, the union of materials chemistry with multicomponent reactions (MCRs) opens a new avenue leading to the realm of highly innovative functionalized architectures with unique features. MCRs have recently been recognized as considerable part of the synthetic chemist's toolbox due to their great efficiency, inherent molecular diversity, atom and pot economy along with operational simplicity...
August 14, 2018: ACS Combinatorial Science
Diana E Ramírez-Ornelas, Rebeca Sola-Llano, Jorge Bañuelos, Iñigo López Arbeloa, José A Martínez-Álvarez, Héctor M Mora-Montes, Bernardo Franco, Eduardo Peña-Cabrera
A series of complex boronic acids were prepared through multicomponent reactions (MCRs). Both Passerini and Ugi MCRs were carried out in which one component was an arylboronic acid. The resulting highly functionalized boronic acids participated efficiently in the Liebeskind-Srogl cross-coupling reaction with meso -methylthioBODIPY derivatives to yield complex borondipyrromethene (BODIPY) dyes in good yields. The joined spectroscopic and computational study points out the deep impact of the arylated chromophoric position on the photophysical signatures...
July 31, 2018: ACS Omega
Danil P Zarezin, Olga I Shmatova, Valentine G Nenajdenko
An efficient three-step synthesis of a novel family of enantiomerically pure isocyanides derived from β3-isocyanopropionic acids was elaborated. Easily available N-formylated α-amino acids were used as starting materials towards this aim. The 3-step sequence (Arndt-Eistert reaction-Wolff rearrangement-dehydration) resulted in target isonitriles in good yields (up to 97%). As a result a new family of isocyanides bearing a fragment of β3-amino acids with different functional groups (amides, esters and short peptides) was obtained...
August 7, 2018: Organic & Biomolecular Chemistry
Mariana Panayotova-Pencheva, Vassilena Dakova, Anetka Trifonova
A nematode species from the Protostrongylidae family, unknown in the parasite fauna of Bulgaria until now, was found in the bronchi of a European brown hare (Lepus europaeus Pallas, 1778 L.) from a southwestern region of the country. At first the systematic identification of the found specimens was attributed to two possibilities-Protostrongylus terminalis Passerini (1884) Schulz, Orlow & Kutass, 1933 and Protostrongylus cuniculorum (Joyeux & Gaud, 1946) Schulz & Kadenazii, 1949. The autonomy of these two species was discussed based on data available in the literature...
August 3, 2018: Parasitology Research
Taous Saraoui, Françoise Leroi, Frédérique Chevalier, Jean-Michel Cappelier, Delphine Passerini, Marie-France Pilet
Listeria monocytogenes is a Gram-positive pathogen occurring in many refrigerated ready-to-eat foods. It is responsible for foodborne listeriosis, a rare but severe disease with a high mortality rate (20-30%). Lactococcus piscium CNCM I-4031 has the capacity to prevent the growth of L. monocytogenes in contaminated peeled and cooked shrimp and in a chemically defined medium using a cell-to-cell contact-dependent mechanism. To characterize this inhibition further, the effect of L. piscium was tested on a collection of 42 L...
2018: Frontiers in Microbiology
Aline Wolfensberger, Lauren Clack, Stefan P Kuster, Simone Passerini, Lona Mody, Vineet Chopra, Jason Mann Msa, Hugo Sax
OBJECTIVE: The transfer of pathogens may spread antimicrobial resistance and lead to healthcare-acquired infections. We performed a systematic literature review to generate estimates of pathogen transfer in relation to healthcare provider (HCP) activities. METHODS: For this systematic review and meta-analysis, Medline/Ovid, EMBASE, and the Cochrane Library were searched for studies published before July 7, 2017. We reviewed the literature, examining transfer of pathogens associated with HCP activities...
July 24, 2018: Infection Control and Hospital Epidemiology
Ivana Šagud, Debora Zanolla, Beatrice Perissutti, Nadia Passerini, Irena Škorić
Praziquantel (PZQ) is an inexpensive, low toxicity BCS II class anthelmintic drug used for the treatment of neglected tropical diseases. In earlier papers a mechanochemical activation has been used to induce physical transformations on the drug which would ameliorate its solubility and hence its bioavailability and a systematic study of the effects of varying temperature, frequency and time of milling on drug melting enthalpy and drug recovery was given. In this communication, the focus is on the degradation products that are formed during this mechanical treatment of Praziquantel...
July 5, 2018: Journal of Pharmaceutical and Biomedical Analysis
Guk-Tae Kim, Stefano Passerini, Maria Carewska, Giovanni Battista Appetecchi
Li⁺-conducting polyethylene oxide-based membranes incorporating N -butyl- N -methylpyrrolidinium bis(trifluoromethanesulfonyl)imide are used as electrolyte separators for all-solid-state lithium polymer batteries operating at medium-high temperatures. The incorporation of the ionic liquid remarkably improves the thermal, ion-transport and interfacial properties of the polymer electrolyte, which, in combination with the wide electrochemical stability even at medium-high temperatures, allows high current rates without any appreciable lithium anode degradation...
July 10, 2018: Membranes
Xinwei Dou, Ivana Hasa, Damien Saurel, Maria Jauregui, Daniel Buchholz, Teófilo Rojo, Stefano Passerini
The investigation of phosphoric acid treatment on the performance of hard carbon from a typical lignocellulosic biomass waste (peanut shell) is herein reported. A strong correlation is discovered between the treatment time and the structural properties and electrochemical performance in sodium-ion batteries. Indeed, a prolonged acid treatment enables the use of lower temperatures, that is, lower energy consumption, for the carbonization step as well as improved high-rate performance (122 mAh g-1 at 10 C)...
July 1, 2018: ChemSusChem
Ana G Neo, Carlos F Marcos
Enols are used for the first time in a condensation with aldehydes and isocyanides to selectively give three- or pseudo-four-component adducts, depending on the reaction conditions. These new transformations have proven to be a convenient alternative for the synthesis of biologically relevant pyrrolidinones containing peptidic or pseudo-peptidic groups on carbon 3. More importantly, this work attests to the utility of heterocyclic enols containing conjugated electron-withdrawing groups as useful reagents in isocyanide-based multicomponent reactions...
July 6, 2018: Organic Letters
Yuan Ma, Yanjiao Ma, Dominic Bresser, Yuanchun Ji, Dorin Geiger, Ute Kaiser, Carsten Streb, Alberto Varzi, Stefano Passerini
Transition metal sulfides are appealing electrode materials for lithium and sodium batteries owing to their high theoretical capacity. However, they are commonly characterized by rather poor cycling stability and low rate capability. Herein, we investigate CoS2 , serving as a model compound. We synthesized a porous CoS2 /C micro-polyhedron composite entangled in a carbon-nanotube-based network (CoS2 -C/CNT), starting from zeolitic imidazolate frameworks-67 as a single precursor. Following an efficient two-step synthesis strategy, the obtained CoS2 nanoparticles are uniformly embedded in porous carbonaceous micro-polyhedrons, interwoven with CNTs to ensure high electronic conductivity...
July 24, 2018: ACS Nano
Jordy M Saya, Rayan Berabez, Pim Broersen, Imme Schuringa, Art Kruithof, Romano V A Orru, Eelco Ruijter
A new Passerini-type reaction in which hexafluoroisopropanol functions as the acid component is reported. The reaction tolerates a broad range of isocyanides and aldehydes, and the formed imidates can be reduced toward β-amino alcohols under mild and metal-free conditions. In addition, the imidate products were shown to undergo an unprecedented retro-Passerini-type reaction under microwave conditions, providing valuable mechanistic information about the Passerini reaction and its variations.
July 6, 2018: Organic Letters
Bruno B Ravanello, Nalin Seixas, Oscar E D Rodrigues, Rafael S da Silva, Marcos A Villetti, Andrej Frolov, Daniel G Rivera, Bernhard Westermann
Aiming at providing an efficient and versatile method for the diversity-oriented decoration and ligation of fullerenes, we report the first C60 derivatization strategy based on isocyanide-multicomponent reactions (I-MCRs). The approach comprises the use of Passerini and Ugi reactions for assembling pseudo-peptidic scaffolds (i.e., N-alkylated and depsipeptides, peptoids) on carboxylic acid-functionalized fullerenes. The method showed wide substrate scope for the oxo and isocyanide components, albeit the Ugi reaction proved efficient only for aromatic amines...
July 11, 2018: Chemistry: a European Journal
Rocco Piazza, Vera Magistroni, Sara Redaelli, Mario Mauri, Luca Massimino, Alessandro Sessa, Marco Peronaci, Maciej Lalowski, Rabah Soliymani, Caterina Mezzatesta, Alessandra Pirola, Federica Banfi, Alicia Rubio, Delphine Rea, Fabio Stagno, Emilio Usala, Bruno Martino, Leonardo Campiotti, Michele Merli, Francesco Passamonti, Francesco Onida, Alessandro Morotti, Francesca Pavesi, Marco Bregni, Vania Broccoli, Marc Baumann, Carlo Gambacorti-Passerini
SETBP1 variants occur as somatic mutations in several hematological malignancies such as atypical chronic myeloid leukemia and as de novo germline mutations in the Schinzel-Giedion syndrome. Here we show that SETBP1 binds to gDNA in AT-rich promoter regions, causing activation of gene expression through recruitment of a HCF1/KMT2A/PHF8 epigenetic complex. Deletion of two AT-hooks abrogates the binding of SETBP1 to gDNA and impairs target gene upregulation. Genes controlled by SETBP1 such as MECOM are significantly upregulated in leukemias containing SETBP1 mutations...
June 6, 2018: Nature Communications
Stefan Oelmann, Alessandra Travanut, Dennis Barther, Manuel Romero, Steven M Howdle, Cameron Alexander, Michael A R Meier
A Passerini three-component polymerization was performed for the synthesis of amphiphilic star-shaped block copolymers with hydrophobic cores and hydrophilic coronae. The degree of polymerization of the hydrophobic core was varied from 5 to 10 repeating units, and the side chain ends were conjugated by performing a Passerini-3CR with PEG-isocyanide and PEG-aldehyde (950 g/mol). The resulting amphiphilic star-shaped block copolymers contained thioether groups, which could be oxidized to sulfones in order to further tune the polarity of the polymer chains...
June 15, 2018: Biomacromolecules
Dario Pasquale Mucciolo, Vittoria Murro, Dario Giorgio, Ilaria Passerini, Andrea Sodi, Gianni Virgili, Stanislao Rizzo
PURPOSE: To report a long-term follow-up of a CRB1-associated maculopathy. METHODS: A case report. RESULTS: A 47-year-old man was diagnosed with bilateral maculopathy. The clinical picture and the foveoschisis abnormalities present in the right eye were consistent with X-linked retinoschisis. During the follow-up we observed the spontaneous passage from a foveal schitic shape to a cystic profile and then to atrophic maculopathy. Two pathogenic CRB1 mutations were detected and he was subsequently diagnosed with CRB1-associated maculopathy...
August 2018: Ophthalmic Genetics
Eliana Alcaraz, Carlos Garcia, Mariana Papalia, Carlos Vay, Laura Friedman, Beatriz Passerini de Rossi
PURPOSE: The aim of this work was to investigate the presence of selected potential virulence factors, susceptibility and clonal relatedness among 63 Stenotrophomonas maltophilia isolates recovered from patients exposed to invasive devices in a university hospital in Argentina between January 2004 and August 2012. METHODOLOGY: Genetic relatedness was assessed by enterobacterial repetitive intergenic consensus PCR (ERIC-PCR) and pulsed-field gel electrophoresis (PFGE)...
May 25, 2018: Journal of Medical Microbiology
Carlo Gambacorti-Passerini, Jorge E Cortes, Jeff H Lipton, Hagop M Kantarjian, Dong-Wook Kim, Philippe Schafhausen, Rocco Crescenzo, Nathalie Bardy-Bouxin, Mark Shapiro, Kay Noonan, Eric Leip, Liza DeAnnuntis, Tim H Brümmendorf, H Jean Khoury
Bosutinib is a Src/Abl tyrosine kinase inhibitor indicated for adults with newly-diagnosed Philadelphia positive chronic myeloid leukemia or with resistant/intolerant disease. We report the final results of a phase I/II study of second-line bosutinib in chronic phase chronic myeloid leukemia patients after imatinib failure (n=284). Median follow up and treatment durations were 54.8 (range 0.6-96.3) and 25.6 (0.2-96.3) months, respectively. At years 2 and 5, 54% and 40% of patients, respectively, remained on bosutinib...
August 2018: Haematologica
Matteo A Manini, Gavin Whitehouse, Matthew Bruce, Matteo Passerini, Tiong Y Lim, Ivana Carey, Aisling Considine, Pietro Lampertico, Abid Suddle, Nigel Heaton, Michael Heneghan, Kosh Agarwal
BACKGROUND: Recent data suggest that oral third-generation nucleos(t)ide analogs (NA) monoprophylaxis following hepatitis B immunoglobulin (HBIg) withdrawal may be effective to prevent HBV reinfection after liver transplantation (LT). PATIENTS AND METHODS: Between 01/2010 and 03/2012, all HBV monoinfected and HBV/HDV co-infected LT patients followed in our centre withdrew HBIg ± NA and were commenced on either ETV or TDF as monotherapy. RESULTS: Seventy-seven patients were included in the study (55% TDF, 45% ETV)...
April 13, 2018: Digestive and Liver Disease
Marta Serafini, Alessia Griglio, Silvio Aprile, Fabio Seiti, Cristina Travelli, Franco Pattarino, Giorgio Grosa, Giovanni Sorba, Armando A Genazzani, Sara Gonzalez-Rodriguez, Laura Butron, Isabel Devesa, Asia Fernandez-Carvajal, Tracey Pirali, Antonio Ferrer-Montiel
Despite being an old molecule, capsaicin is still a hot topic in the scientific community, and the development of new capsaicinoids is a promising pharmacological approach in the management of skin disorders related to inflammation and pruritus. Here we report the synthesis and the evaluation of capsaicin soft drugs that undergo deactivation by the hydrolyzing activity of skin esterases. The implanting of an ester group in the lipophilic moiety of capsaicinoids by the Passerini multicomponent reaction affords both agonists and antagonists that retain transient receptor potential vanilloid 1 channel (TRPV1) modulating activity and, at the same time, are susceptible to hydrolysis...
May 24, 2018: Journal of Medicinal Chemistry
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