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Jon G Divine, Joseph F Clark, Angelo J Colosimo, John P Detherage, Michael A Donaworth, Kimberly A Hasselfeld, Aaron Himmler, Joseph T Rauch, Robert E Mangine
OBJECTIVE: This study was designed to identify changes in blood biomarkers that would indicate excessive muscle breakdown during the initial 10 days of preseason training in collegiate American football players and subsequently increase their risk of acute kidney injury (AKI). DESIGN: Prospective cohort study. SETTING: Preseason, heat acclimatization period. PARTICIPANTS: Twenty-five Division I American football players...
August 16, 2018: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
Masaru Ishida, Shigeru Miyagawa, Atsuhiro Saito, Satsuki Fukushima, Akima Harada, Emiko Ito, Fumiya Ohashi, Tadashi Watabe, Jun Hatazawa, Katsuhisa Matsuura, Yoshiki Sawa
BACKGROUND: Somatic stem cell (SC) therapy can improve cardiac performance following ischemic injury. In this study, we investigated whether induced pluripotent SC-derived cardiomyocytes (iPS-CMs) are more effective than somatic SCs, such as skeletal myoblasts (SM) and mesenchymal (M)SCs, in promoting functional recovery upon transplantation in a porcine model of myocardial infarction (MI). METHODS: Myocardial injury was induced by ameroid ring placement in immunosuppressed female mini-pigs; after 1 month, epicardial cell transplantation was performed with iPS-CMs (n = 7), SMs (n = 7), and MSCs (n = 7)...
August 17, 2018: Transplantation
Kai Xu, Chiyuan Ma, Langhai Xu, Jisheng Ran, Lifeng Jiang, Yuzhe He, Safwat Adel Abdo Moqbel, Zhan Wang, Lidong Wu
Osteoarthritis (OA) is a chronic degenerative joint disease that has been shown to be closely related to the over expression of matrix metalloproteinases (MMPs). Polygalacic acid is a triterpene isolated from the root of Polygala tenuifolia Willd. In the present study, the anti-inflammatory effect of polygalacic acid in OA was investigated as well as its in vitro and in vivo mechanism. In vitro, rat chondrocytes were induced with interleukin-1beta (IL-1β) and treated with different concentrations of polygalacic acid; real-time PCR and Western blotting were performed to evaluate the expressions of MMP-3, MMP-9, MMP-13, and COX-2...
August 13, 2018: International Immunopharmacology
Hanna Lewandowska, Tomasz M Stępkowski, Sylwia Męczyńska-Wielgosz, Katarzyna Sikorska, Jarosław Sadło, Jakub Dudek, Marcin Kruszewski
[Fe(NO)2 ] - modified nanoparticles of low-density protein (DNICLDL) can serve as conveyors of iron in the form of stable complexes with ApoB100 protein. As reported recently, in human hepatoma cells DNICLDL significantly increased the total iron content, while showing low toxicity. In the present work, we focused on the effects of internalization of DNIC-modified lipoproteins in macrophages, with special regards to cytotoxicity. DNICLDL was administered to a model macrophage cell line, RAW 264.7. Administration of DNICLDL considerably increased total iron content...
August 4, 2018: Journal of Inorganic Biochemistry
Salida Mirzoeva, Xin Tong, Bryan B Bridgeman, Michael P Plebanek, Olga V Volpert
We have previously demonstrated that apigenin promotes the expression of antiangiogenic protein thrombospondin-1 (TSP1) via a mechanism driven by mRNA-binding protein HuR. Here, we generated a novel mouse model with whole-body THBS-1 gene knockout on SKH-1 genetic background, which allows studies of UVB-induced acute skin damage and carcinogenesis and tests TSP1 involvement in apigenin's anticancer effects. Apigenin significantly inhibited UVB-induced carcinogenesis in the wild-type (WT) animals but not in TSP1 KO (TKO) mice, suggesting that TSP1 is a critical component of apigenin's chemopreventive function in UVB-induced skin cancer...
August 14, 2018: Neoplasia: An International Journal for Oncology Research
Haiying Liu, Yujie Xie, Zepeng Zhang, Pingsu Mao, Jingfan Liu, Wenbin Ma, Yong Zhao
About 15% of human cancers counteract telomere loss by alternative lengthening of telomeres (ALT), which is attributed to homologous recombination (HR)-mediated events. But how telomeric HR leads to length elongation is poorly understood. Here, we explore telomere clustering and telomeric HR induced by double-stranded breaks (DSBs). We show that telomere clustering could occur at G1 and S phase of cell cycle and that three types of telomeric HR occur based on the manner of telomeric DNA exchange: equivalent telomeric sister chromatin exchange (T-SCE), inequivalent T-SCE, and No-SCE...
August 14, 2018: Neoplasia: An International Journal for Oncology Research
Lekkala Ravindar, S N A Bukhari, K P Rakesh, H M Manukumar, H K Vivek, N Mallesha, Zhi-Zhong Xie, Hua-Li Qin
A series of aryl fluorosulfate analogues (1-37) were synthesized and tested for in vitro antibacterial and antifungal studies, and validated by docking studies. The compounds 9, 12, 14, 19, 25, 26, 35, 36 and 37 exhibited superior antibacterial potency against tested bacterial strains, while compounds 2, 4, 5, 15, 35, 36 and 37 were found to have better antifungal activity against tested fungal strains, compared to standard antibiotic gentamicin and ketoconazole respectively. Among all the synthesized 37 analogs, compounds 25, 26, 35, 36 and 37 displayed excellent anti-biofilm property against Staphylococcus aureus...
August 6, 2018: Bioorganic Chemistry
Yulei Liu, Tao Yang, Lu Wang, Zhuangsong Huang, Juan Li, Haijun Cheng, Jin Jiang, Suyan Pang, Jingyao Qi, Jun Ma
Natural organic matter (NOM) ubiquitously exists in natural waters and would adsorb onto the particle surface. Previous studies showed that NOM would alleviate the toxicity of nanomaterials, while the mechanism is seldom quantitatively interpreted. Herein, the effects of humic substances [Suwannee River fulvic acid (SRFA) and Suwannee River humic acid (SRHA)] and biomacromolecules [alginate and bovine serum albumin (BSA)] on the aggregation and antimicrobial effects of silver sulfide nanoparticles (Ag2 S-NPs) were investigated...
July 26, 2018: Water Research
Xueyuan Hu, Qianru Chi, Dongxu Wang, Xin Chi, Xiaohua Teng, Shu Li
Hydrogen sulfide (H2 S) is widely accepted to be a signaling molecule that exhibits some potentially beneficial therapeutic effects at physiological concentrations. At elevated levels, H2 S is highly toxic and has a negative effect on human health and animal welfare. Studies have shown that H2 S exposure induces an immune function in mice, but there are few studies of the effect of continuous H2 S exposure on immune organs in poultry. In this study, one-day-old broilers were selected and exposed to 4 or 20 ppm of H2 S gas for 14, 28 and 42 days of age...
August 13, 2018: Ecotoxicology and Environmental Safety
Hyejin Kim, Sung Won Kim, Kwang Hyuk Seok, Chi Woo Hwang, Jin-Chul Ahn, Jun-O Jin, Hyun Wook Kang
BACKGROUND: Hypericin (HYP) extracted from St. John's wort ( Hypericum perforatum L.) is a natural photosensitizer in clinical photodynamic therapy (PDT). The PDT is one of the powerful methods for cancer treatments because of its excellent tumoritropic characteristics and photosensitizing properties. However, limited reports on the efficacy of PDT on the anaplastic thyroid cancer (ATC) have been published. Especially HYP-associated PDT has not been investigated in vitro and in vivo. In this study, we evaluated the effect of HYP for PDT against FRO ATC cells...
August 14, 2018: Photodiagnosis and Photodynamic Therapy
Thamara Figueiredo Procópio, Leydianne Leite de Siqueira Patriota, Bárbara Rafaela da Silva Barros, Lethícia Maria de Souza Aguiar, Virgínia Maria Barros de Lorena, Patrícia Maria Guedes Paiva, Cristiane Moutinho Lagos de Melo, Thiago Henrique Napoleão
CasuL is a lectin (carbohydrate-binding protein) isolated from the leaf pinnulae of Calliandra surinamensis that is toxic against cancer cells. In this study, the effects of CasuL on the activation of immune cells were evaluated in BALB/c mice splenocytes. Assays measuring the changes in cytosolic calcium concentration ([Ca2+ ]cyt ), mitochondrial membrane potential (ΔΨm), and reactive oxygen species (ROS) levels associated with cell viability, proliferation, and cytokine and nitric oxide production were performed...
August 14, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Chandrashekhar Singh, Chandra Prakash, Kavindra Nath Tiwari, Sunil Kumar Mishra, Vijay Kumar
The present study was designed to evaluate the ameliorative effect of ethyl acetate extract of Premna integrifolia L. (EAEPI) leaves in cyclophosphamide (CP)-induced hepatic injury in mice. Mice were intoxicated with CP (200 mg/kg b. wt., i.p.) for 5 weeks or EAEPI (400 and 600 mg/kg b. wt., orally) in combination with CP. The results demonstrated that EAEPI exerts protective effect against CP induced hepatotoxicity, as evident from restoration of altered haematological parameters and alleviations of liver marker enzymes in serum...
August 14, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Yuehong Wang, Linying Wu, Yinan Yao, Guohua Lu, Liming Xu, Jianying Zhou
The prognosis of small cell lung cancer (SCLC) is poor despite its good initial response to chemotherapy. Polo-like kinase 1 (PLK1) is a crucial mitotic regulator that is overexpressed in many tumors, and its overexpression is associated with tumor aggressiveness and a poor prognosis. However, its role in SCLC is still poorly characterized. Based on immunohistochemistry findings, the PLK1 protein is expressed at higher levels in SCLC tumor samples than in normal lung tissue samples. The selective PLK1 inhibitor BI 6727 significantly induced the inhibition of proliferation and apoptosis in a dose-dependent manner in SCLC cell lines...
August 14, 2018: Cancer Letters
Aravind T Reddy, Sowmya P Lakshmi, Asoka Banno, Raju C Reddy
Cigarette smoke, a source of numerous oxidants, produces oxidative stress and exaggerated inflammatory responses that lead to irreversible lung tissue damage. It is the single, most significant risk factor for chronic obstructive pulmonary disease (COPD). Although an intrinsic defense system that includes both enzymatic and non-enzymatic players exists to protect lung tissues against oxidative stress, impairment of these protective mechanisms has been demonstrated in smokers and COPD patients. The antioxidant enzyme GSH peroxidase (GPx) is an important part of this intrinsic defense system...
August 14, 2018: Free Radical Biology & Medicine
Xingyu Duan, Aislinn Hays, Wei Zhou, Nawar Sileewa, Satya Upadhyayula, Huizhi Wang, Shuang Liang
Although pregnant women are prone to gingival inflammation, its mechanism remains unclear. Animal models are ideal for investigating immunological mechanisms in the periodontal disease. A murine model for ligature-induced periodontal disease has been modified and utilized to determine the susceptibility to periodontal inflammation and tissue damage in pregnant mice. Expression of different inflammatory mediators in the gingivae was determined by quantitative real-time PCR (qPCR). Inflammatory bone loss was determined by measuring the distance from the cementoenamel junction to the alveolar bone crest (CEJ-ABC)...
August 14, 2018: Microbial Pathogenesis
Praveen Rishi, Shania Vij, Indresh Kumar Maurya, Ujjwal Jit Kaur, Sanjay Bharati, Rupinder Tewari
Fast emerging antibiotic resistance in pathogens requires special attention for strengthening the reservoir of antimicrobial compounds. In view of this, several peptides with known antimicrobial activities have been reported to enhance the efficacy of antibiotics against multidrug resistant (MDR) pathogens. In the present study, potential of peptides having distinct mechanism of action, if any, was evaluated to improve the efficacy of conventional antibiotics against methicillin-resistant S. aureus (MRSA). After primary screening of six peptides, two peptides namely T3 and T4 showing very high minimum inhibitory concentrations (MICs) were selected to assess their role in altering the MICs of antibiotics to which the pathogen was resistant...
August 14, 2018: Microbial Pathogenesis
Mary Ângela Aranda-Souza, Virginia Maria Barros de Lorena, Maria Tereza Dos Santos Correia, Regina Célia Bressan Queiroz de Figueiredo
Leishmania amazonensis and Leishmania braziliensis are the main causative agents of American Tegumentary Leishmaniasis (ATL) in Brazil. As intracellular parasites, the infection by Leishmania species is dependent on the host immune response and the immunotherapy could be promissory for the development of new strategies to combat ATL. In this work we investigated the leishmanicidal potential of a galactose-binding lectin from the snake venom of Bothrops leucurus (BLL) during the infection with L. amazonensis and L...
August 14, 2018: International Journal of Biological Macromolecules
M S Sajid, A Kausar, A Iqbal, H Abbas, Z Iqbal, M K Jones
Ticks (Acari:Ixodoidea) are important ectoparasites infesting livestock and human populations around the globe. Ticks can cause damage directly by affecting the site of infestation, or indirectly as vectors of a wide range of protozoa, bacteria and viruses which ultimately lead to lowered productivity of livestock populations. Hyalomma is a genus of hard ticks, having more than 30 species well-adapted to hot, humid and cold climates. Habitat diversity, vector ability, and emerging problem of acaricidal resistance in enzootic regions typify this genus in various countries around the world...
August 14, 2018: Acta Tropica
Onintza Sagredo, Javier Palazuelos, Ana Gutierrez-Rodriguez, Valentina Satta, Ismael Galve-Roperh, José Martínez-Orgado
The endocannabinoid system exerts a crucial neuromodulatory role in many brain areas that is essential for proper regulation of neuronal activity. The role of cannabinoid signalling controlling neuronal activity in the adult brain is also evident when considering its contribution to adult brain insults or neurodegenerative diseases. In the context of brain genetic or acquired encephalopathies administration of cannabinoid-based molecules has demonstrated to exert symptomatic relief and hence, they are proposed as new potential therapeutic compounds...
August 14, 2018: Biochemical Pharmacology
Naomie Castor, Farid El Massioui
BACKGROUND: Traumatic brain injury and stroke often lead to cognitive, neurological and psychological disorders, which can result in many difficulties. Despite the existence of various disorders, improving cognitive capacities may be possible for these two pathologies. OBJECTIVES: The purpose of this study was to assess cognitive recovery in patients with traumatic brain injury and stroke and compare recovery between both groups. PARTICIPANTS AND METHODS: Forty-nine adults who had suffered from mild to severe traumatic brain injury and 42 from stroke were assessed third with a minimum of 2 months between assessments...
August 17, 2018: Brain Injury: [BI]
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