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Damage Controll

Zhenning Li, Cong Chen, Yusheng Ci, Guohui Zhang, Qiong Wu, Cathy Liu, Zhen Sean Qian
Traffic crashes are more likely to occur at intersections where the traffic environment is complicated. In this study, a hybrid approach combining cluster analysis and hierarchical Bayesian models is developed to examine driver injury severity patterns in intersection-related crashes based on two-year crash data in New Mexico. Three clusters are defined by K-means cluster analysis based on weather and roadway environmental conditions in order to reveal drivers' risk compensation instability under diverse external environment...
August 15, 2018: Accident; Analysis and Prevention
Cleetus Cherupanakkal, Daisy Mariya Samadanam, Krishna Raja Muthuraman, Surya Ramesh, Amrit Venkatesan, Agiesh Kumar Balakrishna Pillai, Soundravally Rajendiran
Interplay between the apoptosis, DNA damage, and oxidative stress as a host response to dengue viral infections remains unclear. Peripheral blood mononuclear cells (PBMCs) were isolated from 60 dengue infected patients, 20 patients with febrile illness other than dengue (OFI) and 10 non-febrile illness (NFI) patients. DNA damage in the PBMCs was assessed using single cell gel electrophoresis and stages of apoptosis underwent by the PBMCs were studied by Annexin-PI staining using flow cytometry. Plasma levels of malondialdehyde levels were estimated using thiobarbituric acid assay...
August 18, 2018: IUBMB Life
Ichiro Tamaki, Koichiro Hata, Yusuke Okamura, Yermek Nigmet, Hirofumi Hirao, Toyonari Kubota, Osamu Inamoto, Jiro Kusakabe, Toru Goto, Tetsuya Tajima, Junichi Yoshikawa, Hirokazu Tanaka, Tatsuaki Tsuruyama, Rene H Tolba, Shinji Uemoto
Cold storage (CS) remains the gold standard for organ preservation worldwide, though it is inevitably associated with cold-ischemia/warm-reperfusion injury (IRI). Molecular hydrogen (H2 ) is well-known to have anti-oxidative properties, however, its unfavorable features, i.e. inflammability, low solubility, and high tissue/substance permeability, have hampered its clinical application. To overcome such obstacles, we developed a novel reconditioning method for donor organs, named HyFACS (hydrogen flush after cold storage), just an end-ischemic H2 -flush directly to donor organs ex vivo, and herein report its therapeutic impact against hepatic IRI...
August 18, 2018: Liver Transplantation
Wan-Chien Cheng, Fahd Saleh, Belkais Abuaisha Karim, Francis J Hughes, Leonie S Taams
Periodontitis is a chronic inflammatory disease caused by the colonisation of teeth by the bacterial plaque biofilm and the resultant host immune responses in adjacent periodontal tissues. Disease severity can vary dramatically between patients with periodontitis, with some subjects displaying inflammation without bony destruction (gingivitis), whilst others experience chronic progressive or rapidly aggressive gingival connective tissue damage and bone loss. To determine whether peripheral immune dysregulation is associated with periodontitis, we performed extensive analysis of immune cell subsets in peripheral blood from patients with chronic or aggressive periodontitis vs...
August 18, 2018: Clinical and Experimental Immunology
Pierre Maurage, Séverine Lannoy, Valérie Dormal, Marine Blanco, Jean-Baptiste Trabut
BACKGROUND: Decision-making impairments have been repeatedly evaluated in severe alcohol use disorders (SAUD) using the Iowa Gambling Task (IGT). The IGT, capitalizing on strong theoretical background and ecological significance, allowed identifying large-scale deficits in this population and is now a standard decision-making assessment in therapeutic settings. However, the clinical usefulness of the IGT, particularly regarding its ability to predict relapse and its link with key cognitive-physiological deficits, remains to be clarified...
August 18, 2018: Alcoholism, Clinical and Experimental Research
Yue Zheng, Wen-Cheng Zhang, Ze-Yu Wu, Chuan-Xiang Fu, Ai-Ling Hui, Han Gao, Peng-Peng Chen, Biao Du, Hua-Wei Zhang
BACKGROUND: Macamides, the main active component contained in maca, have attracted increasing attention due to their various bioactivities. In this study, crude macamides extract (CME) and purified macamides extract (PME) were prepared by enzyme-assisted extraction and macroporous resin separation, and anti-fatigue effects of CME and PME were evaluated in a forced swimming model. RESULTS: The composition analysis results revealed that both CME and PME mainly contain 8 kinds of macamides...
August 17, 2018: Journal of the Science of Food and Agriculture
Gabriel Carvalho Coppo, Larissa Souza Passos, Taciana Onesorge Miranda Lopes, Tatiana Miura Pereira, Julia Merçon, Dandara Silva Cabral, Bianca Vieira Barbosa, Lívia Sperandio Caetano, Edgar Hell Kampke, Adriana Regina Chippari-Gomes
Manganese and iron were found at high concentrations (3.61 mg/L and 19.8 mg/L, respectively) in the water of the Rio Doce after the dams of Fundão and Santarém broke in Mariana/MG (Brazil). These same metals were found in fish and crustacean muscle (15 mg/kg and 8 mg/kg wet weight, respectively) in the specimens collected near the Rio Doce's outfall. Due to the variation in Mn concentration found in the lower Rio Doce, this study aimed to determine the effects of Mn in Oreochromis niloticus, at the concentrations allowed by CONAMA, and in concentrations found in the Rio Doce after the dams broke...
August 17, 2018: Ecotoxicology
Amina Metidji, Sara Omenetti, Stefania Crotta, Ying Li, Emma Nye, Ellie Ross, Vivian Li, Muralidhara R Maradana, Chris Schiering, Brigitta Stockinger
The epithelium and immune compartment in the intestine are constantly exposed to a fluctuating external environment. Defective communication between these compartments at this barrier surface underlies susceptibility to infections and chronic inflammation. Environmental factors play a significant, but mechanistically poorly understood, role in intestinal homeostasis. We found that regeneration of intestinal epithelial cells (IECs) upon injury through infection or chemical insults was profoundly influenced by the environmental sensor aryl hydrocarbon receptor (AHR)...
August 1, 2018: Immunity
Catherine Go, Youngjae J Chun, Jenna Kuhn, Yanfei Chen, Sung Kwon Cho, William C Clark, Bryan W Tillman
OBJECTIVE: Early hemorrhage control before the operating room is essential to reduce the significant mortality associated with traumatic injuries of the vena cava. Conventional approaches present logistical challenges on the battlefield or in the trauma bay. A retrievable stent graft would allow rapid hemorrhage control in the preoperative setting when endovascular expertise is not immediately available and without committing a patient to the limitations of current permanent stents. This study details a refined retrievable Rescue stent for percutaneous delivery that was examined in a porcine survival model of penetrating caval hemorrhage...
September 2018: Journal of Vascular Surgery. Venous and Lymphatic Disorders
Jessica S Poisson, Jason P Acker, Jennie G Briard, Julia E Meyer, Robert N Ben
Ice formation remains central to our understanding of the effects of low temperatures on the biological response of cells and tissues. The formation of ice inside of cells and the net increase of crystal size due to recrystallization during thawing is associated with a loss of cell viability during cryopreservation. As small molecule ice recrystallization inhibitors (IRIs) can control the growth of extracellular ice, we sought to investigate the ability of two aryl glycoside-based IRIs to permeate into cells and control intracellular ice recrystallization...
August 17, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
Aida Kahal, Rachida Allem
The importance of the present study comes from the lack of sufficient information about the reversibility of the histopathological alterations which may result from anabolic androgenic drugs abuse after some times of stop treatment, as it is one of the prior studies which explored the negative effects of Deca-Durabolin abuse in particular on the hearts, kidneys and testis structures. For this aim, study was performed on 40 male adult mices. Animals were divided into five groups of 8 animals each as follows: treated by Deca-Durabolin (nandrolone decanoate) at 30 g/kg of BW, weekly during one month (GI); two months (GII); three months (GIII); three months followed by six weeks of treatment discontinuation (GIV) and Control (C)...
July 12, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Masaru Ishida, Shigeru Miyagawa, Atsuhiro Saito, Satsuki Fukushima, Akima Harada, Emiko Ito, Fumiya Ohashi, Tadashi Watabe, Jun Hatazawa, Katsuhisa Matsuura, Yoshiki Sawa
BACKGROUND: Somatic stem cell (SC) therapy can improve cardiac performance following ischemic injury. In this study, we investigated whether induced pluripotent SC-derived cardiomyocytes (iPS-CMs) are more effective than somatic SCs, such as skeletal myoblasts (SM) and mesenchymal (M)SCs, in promoting functional recovery upon transplantation in a porcine model of myocardial infarction (MI). METHODS: Myocardial injury was induced by ameroid ring placement in immunosuppressed female mini-pigs; after 1 month, epicardial cell transplantation was performed with iPS-CMs (n = 7), SMs (n = 7), and MSCs (n = 7)...
August 17, 2018: Transplantation
Salida Mirzoeva, Xin Tong, Bryan B Bridgeman, Michael P Plebanek, Olga V Volpert
We have previously demonstrated that apigenin promotes the expression of antiangiogenic protein thrombospondin-1 (TSP1) via a mechanism driven by mRNA-binding protein HuR. Here, we generated a novel mouse model with whole-body THBS-1 gene knockout on SKH-1 genetic background, which allows studies of UVB-induced acute skin damage and carcinogenesis and tests TSP1 involvement in apigenin's anticancer effects. Apigenin significantly inhibited UVB-induced carcinogenesis in the wild-type (WT) animals but not in TSP1 KO (TKO) mice, suggesting that TSP1 is a critical component of apigenin's chemopreventive function in UVB-induced skin cancer...
August 14, 2018: Neoplasia: An International Journal for Oncology Research
M S Sajid, A Kausar, A Iqbal, H Abbas, Z Iqbal, M K Jones
Ticks (Acari:Ixodoidea) are important ectoparasites infesting livestock and human populations around the globe. Ticks can cause damage directly by affecting the site of infestation, or indirectly as vectors of a wide range of protozoa, bacteria and viruses which ultimately lead to lowered productivity of livestock populations. Hyalomma is a genus of hard ticks, having more than 30 species well-adapted to hot, humid and cold climates. Habitat diversity, vector ability, and emerging problem of acaricidal resistance in enzootic regions typify this genus in various countries around the world...
August 14, 2018: Acta Tropica
Onintza Sagredo, Javier Palazuelos, Ana Gutierrez-Rodriguez, Valentina Satta, Ismael Galve-Roperh, José Martínez-Orgado
The endocannabinoid system exerts a crucial neuromodulatory role in many brain areas that is essential for proper regulation of neuronal activity. The role of cannabinoid signalling controlling neuronal activity in the adult brain is also evident when considering its contribution to adult brain insults or neurodegenerative diseases. In the context of brain genetic or acquired encephalopathies administration of cannabinoid-based molecules has demonstrated to exert symptomatic relief and hence, they are proposed as new potential therapeutic compounds...
August 14, 2018: Biochemical Pharmacology
Maria Fernanda Ribeiro Cury, Estéfany Queiroz Olivares, Renata Correia Garcias, Giovana Queda Toledo, Natassia Alberici Anselmo, Leticia Colombo Paskakulis, Fernanda Fortuci Resende Botelho, Natiele Zanardo Carvalho, Analice Andreoli da Silva, Camila Agren, Carla Patrícia Carlos
INTRODUCTION: Ischemia and reperfusion (IR) is a process inherent to the procedures involved in the transplantation of organs that causes inflammation, cell death and cell injury, and may lead to rejection of the graft. It is possible that the anti-inflammatory properties of the Brazil nuts (BN) can mitigate the renal injury caused by IR. OBJECTIVE: To investigate whether the previous intake of BN reduces the expression of markers of inflammation, injury, and cell death after renal IR...
August 16, 2018: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
Michelle L Law, Kurt W Prins, Megan E Olander, Joseph M Metzger
Cardiomyopathy is a significant contributor to morbidity and mortality in Duchenne Muscular Dystrophy (DMD). Membrane instability, leading to intracellular calcium (Ca2+ ) mishandling and overload, causes myocyte death and subsequent fibrosis in DMD cardiomyopathy. On a cellular level, cardiac myocytes from mdx mice have dysregulated Ca2+ handling, including increased resting Ca2+ and slow Ca2+ decay, especially evident under stress conditions. Sarco(endo)plasmic reticulum Ca2+ ATPase and its regulatory protein phospholamban (PLN) are potential therapeutic targets for DMD cardiomyopathy owing to their key role in regulating intracellular Ca2+ cycling...
August 17, 2018: American Journal of Physiology. Heart and Circulatory Physiology
Mehmet Fuat Gulhan
BACKGROUND: Hypertension is described as increased blood pressure based on changed hemodynamics and associated with an increased oxidative damage to reproductive function. This work is to determine therapeutic and protective effects of apitherapy products (propolis and pollen) on reproductive functions of L-NAME-induced hypertensive male rats. METHODS: Experimental animals were indiscriminately separated into four groups of seven rats in each group: (I) Control, (II) L-NAME, (III) L-NAME+ propolis and (IV) L-NAME+ pollen...
August 17, 2018: Clinical and Experimental Hypertension: CHE
Vienna E Brunt, Karen Wiedenfeld-Needham, Lindan N Comrada, Christopher T Minson
KEYPOINTS SUMMARY: Accumulating evidence indicates that passive heat therapy (chronic use of hot tubs or saunas) has widespread physiological benefits, including enhanced resistance against novel stressors ('stress resistance'). Using a cell culture model to isolate the key stimuli that likely underlie physiological adaptation with heat therapy, we showed that both mild elevations in temperature (to 39°C) and exposure to serum from human subjects who have undergone 8 weeks of heat therapy (i...
August 17, 2018: Journal of Physiology
Xing-Hua Shen, Ping Xu, Xi Yu, Hua-Feng Song, Hui Chen, Xue-Guang Zhang, Mei-Ying Wu, Xue-Feng Wang
Accumulating evidence demonstrates that CD8+ CD28- regulatory T cells increase in chronic viral infection as well as tumorigenesis. However, it is still not clear about their characteristics in hepatitis B virus (HBV) infection. In addition, it is not understood whether this regulatory immune subset is distinct from CD4+ CD25high regulatory T cells in the aspect of impact on or relationship to the progression of HBV infection. Hence, we investigated their dynamics and compared their correlations with clinical parameters in the chronic and advanced phases of HBV infection...
August 17, 2018: Viral Immunology
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