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https://www.readbyqxmd.com/read/28920099/fast-virtual-fractional-flow-reserve-based%C3%A2-upon-steady-state-computational-fluid-dynamics-analysis-results-from-the-virtu-fast-study
#1
Paul D Morris, Daniel Alejandro Silva Soto, Jeroen F A Feher, Dan Rafiroiu, Angela Lungu, Susheel Varma, Patricia V Lawford, D Rodney Hose, Julian P Gunn
Fractional flow reserve (FFR)-guided percutaneous intervention is superior to standard assessment but remains underused. The authors have developed a novel "pseudotransient" analysis protocol for computing virtual fractional flow reserve (vFFR) based upon angiographic images and steady-state computational fluid dynamics. This protocol generates vFFR results in 189 s (cf >24 h for transient analysis) using a desktop PC, with <1% error relative to that of full-transient computational fluid dynamics analysis...
August 2017: JACC. Basic to Translational Science
https://www.readbyqxmd.com/read/28918826/islamic-medicine-in-the-middle-ages
#2
EDITORIAL
Hawa Edriss, Brittany N Rosales, Connie Nugent, Christian Conrad, Kenneth Nugent
The Islamic culture flourished between the 9th and 13th centuries. Scholars from this era made significant contributions in mathematics, science and medicine. Caliphs and physicians built hospitals that provided universal care and the foundation for medical education. Physician-scientists made significant advances in medical care, surgery and pharmacology. Notable authorities include al-Razi (865-925 CE) who wrote the Kitab al-Hawi fi al-tibb (The Comprehensive Book on Medicine), a 23-volume textbook that provided the main medical curriculum for European schools into the 14th century...
September 2017: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/28916885/geometric-analysis-and-clinical-outcome-of-two-cemented-stems-for-primary-total-hip-replacement-with-and-without-modular-necks
#3
Marcel Haversath, Christine Wendelborn, Marcus Jäger, Boris Schmidt, Wojciech Kowalczyk, Stefan Landgraeber
INTRODUCTION: Restoration of the physiological biomechanical principles of the hip is crucial in total hip replacement. The aim of this study was to compare an arthroplasty system with different offset options (a: Exeter(®)) with a dual-modular stem (b: Profemur Xm(®)). MATERIALS AND METHODS: A local and an inertial coordinate system were used to assist the description of the components' assembly in the prosthesis. A resection line of the femoral head in standard position was added to the arthroplasties and geometric parameters were measured...
September 15, 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/28916602/validation-study-of-image-based-fractional-flow-reserve-during-coronary-angiography
#4
Mariano Pellicano, Ifat Lavi, Bernard De Bruyne, Hana Vaknin-Assa, Abid Assali, Orna Valtzer, Yonit Lotringer, Giora Weisz, Yaron Almagor, Panagiotis Xaplanteris, Ajay J Kirtane, Pablo Codner, Martin B Leon, Ran Kornowski
BACKGROUND: Fractional flow reserve (FFR), an index of the hemodynamic severity of coronary stenoses, is derived from invasive measurements and requires a pressure-monitoring guidewire and hyperemic stimulus. Angiography-derived FFR measurements (FFRangio) may have several advantages. The aim of this study is to assess the diagnostic performance and interobserver reproducibility of FFRangio in patients with stable coronary artery disease. METHODS AND RESULTS: FFRangio is a computational method based on rapid flow analysis for the assessment of FFR...
September 2017: Circulation. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28916139/online-adaptive-radiation-therapy
#5
REVIEW
Stephanie Lim-Reinders, Brian M Keller, Shahad Al-Ward, Arjun Sahgal, Anthony Kim
The current paradigm of radiation therapy has the treatment planned on a snapshot dataset of the patient's anatomy taken at the time of simulation. Throughout the course of treatment, this snapshot may vary from initial simulation. Although there is the ability to image patients within the treatment room with technologies such as cone beam computed tomography, the current state of the art is largely limited to rigid-body matching and not accounting for any geometric deformations in the patient's anatomy. A plan that was once attuned to the initial simulation can become suboptimal as the treatment progresses unless improved technologies are brought to bear...
April 24, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28913505/periorbital-facial-rejuvenation-applied-anatomy-and-pre-operative-assessment
#6
REVIEW
Mohsen Bahmani Kashkouli, Parya Abdolalizadeh, Navid Abolfathzadeh, Hamed Sianati, Maria Sharepour, Yasaman Hadi
PURPOSE: Since different subspecialties are currently performing a variety of upper facial rejuvenation procedures, and the level of knowledge on the ocular and periocular anatomy and physiology is different, this review aims to highlight the most important preoperative examinations and tests with special attention to the eye and periocular adnexal structures for general ophthalmologist and specialties other than oculo-facial surgeons in order to inform them about the fine and important points that should be considered before surgery to have both cosmetic and functional improvement...
September 2017: Journal of Current Ophthalmology
https://www.readbyqxmd.com/read/28887263/changes-in-geometry-and-cardiac-deformation-of-the-thoracic-aorta-after-thoracic-endovascular-aortic-repair-tevar
#7
Kelsey Hirotsu, Ga-Young Suh, Jason T Lee, Michael D Dake, Dominik Fleischmann, Christopher P Cheng
BACKGROUND: TEVAR has dramatically expanded treatment options for patients with thoracic aortic pathology. The interaction between endografts and the dynamic anatomy of the thoracic aorta is not well characterized for repetitive physiologic stressors and subsequent issues related to long-term durability. Through 3D modeling we sought to quantify cardiac-induced aortic deformation before and after TEVAR to assess the impact of endografts on dynamic aortic anatomy. METHODS: Eight patients with acute (n = 4) or chronic (n = 3) Type B dissections, or chronic arch aneurysm (n = 1), underwent TEVAR with a single (n = 5) or multiple (n = 3) Gore C-TAG(s)...
September 5, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28878733/clinical-approach-to-supranuclear-brainstem-saccadic-gaze-palsies
#8
REVIEW
Alexandra Lloyd-Smith Sequeira, John-Ross Rizzo, Janet C Rucker
Failure of brainstem supranuclear centers for saccadic eye movements results in the clinical presence of a brainstem-mediated supranuclear saccadic gaze palsy (SGP), which is manifested as slowing of saccades with or without range of motion limitation of eye movements and as loss of quick phases of optokinetic nystagmus. Limitation in the range of motion of eye movements is typically worse with saccades than with smooth pursuit and is overcome with vestibular-ocular reflexive eye movements. The differential diagnosis of SGPs is broad, although acute-onset SGP is most often from brainstem infarction and chronic vertical SGP is most commonly caused by the neurodegenerative condition progressive supranuclear palsy...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28874722/ameliorative-effects-of-melatonin-on-dark-induced-leaf-senescence-in-gardenia-gardenia-jasminoides-ellis-leaf-morphology-anatomy-physiology-and-transcriptome
#9
Daqiu Zhao, Rong Wang, Jiasong Meng, Zhiyuan Li, Yanqing Wu, Jun Tao
Cut gardenia (Gardenia jasminoides Ellis) foliage is widely used as a vase material or flower bouquet indoors; however, insufficient indoor light accelerates its senescence, which shortens its viewing time. In this study, applying melatonin to delay gardenia leaf senescence when exposed to extremely low light condition (darkness), and the results showed that 1.0 mM was the effective concentration. At this concentration, chlorophyll contents and chlorophyll fluorescence parameters (Fv/Fm, Fv/F0 and Y(II)) increased, while the carotenoid and flavonoid contents decreased...
September 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28873388/gastrointestinal-endocrinology-in-bariatric-surgery
#10
Martin Wabitsch
The long-lasting weight-reducing effect of bariatric surgical procedures cannot simply be explained by the malabsorption of nutrients and the subsequent energy deficit due to this malabsorption. Clinical studies have shown that the reorganization of the anatomy of the gut and the subsequent alterations of gastrointestinal physiology have a large impact on the secretion and function of gastrointestinal hormones, which regulate hunger and satiety. These changes have been named the BRAVE effect: <under>b</under>ile flow alteration, <under>r</under>eduction of gastric size, <under>a</under>natomical gut rearrangement and altered flow of nutrients, <under>v</under>agal manipulation, and <under>e</under>nteric gut modulation...
2017: Endocrine Development
https://www.readbyqxmd.com/read/28871432/comparative-physiological-and-proteomic-analyses-reveal-different-adaptive-strategies-by-cymbidium-sinense-and-c-tracyanum-to-drought
#11
Jia-Wei Li, Xiao-Dong Chen, Xiang-Yang Hu, Lan Ma, Shi-Bao Zhang
A terrestrial orchid, Cymbidium sinense appears to utilizes "remedy strategy", while an epiphytic orchid, C. tracyanum , employs a "precaution strategy" to drought stress based on morphological, physiological and proteomic analysis. Drought condition influences plant growth and productivity. Although the mechanism by which plants adapt to this abiotic stress has been studied extensively, the water-adaptive strategies of epiphytes grown in water-limited habitats remain undefined. Here, root and leaf anatomies, dynamic changes in physiological and proteomic responses during periods of drought stress and recovery studied in an epiphytic orchid (Cymbidium tracyanum) and a terrestrial orchid (C...
September 4, 2017: Planta
https://www.readbyqxmd.com/read/28871332/rem-sleep-behavior-disorder-autonomic-dysfunction-and-synuclein-related-neurodegeneration-where-do-we-stand
#12
REVIEW
Giacomo Chiaro, Giovanna Calandra-Buonaura, Annagrazia Cecere, Francesco Mignani, Luisa Sambati, Giuseppe Loddo, Pietro Cortelli, Federica Provini
INTRODUCTION: From newfound parasomnia to a marker of future synucleinopathy, since its first description in 1986, REM sleep behavior disorder (RBD) has been systematically tackled from virtually many viewpoints in basic, translational, and clinical studies. The time delay between RBD and synucleinopathy onset offers an exceptional window for observation and design of neuroprotective trials. In the last few years, research has focused on characterizing possible differences within RBD patients in order to draw potential profiles more or less susceptible to further neurodegeneration...
September 4, 2017: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
https://www.readbyqxmd.com/read/28871030/spatiochromatic-interactions-between-individual-cone-photoreceptors-in-the-human-retina
#13
William S Tuten, Wolf M Harmening, Ramkumar Sabesan, Austin Roorda, Lawrence C Sincich
A remarkable feature of human vision is that the retina and brain have evolved circuitry to extract useful spatial and spectral information from signals originating in a photoreceptor mosaic whose trichromatic constituents vary widely in their relative numbers and local spatial configurations. A critical early transformation applied to cone signals is horizontal-cell-mediated lateral inhibition, which imparts a spatially-antagonistic surround to individual cone receptive fields, a signature inherited by downstream neurons and implicated in color signaling...
September 4, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28870377/cardiac-imaging-in-the-diagnosis-of-coronary-artery-disease
#14
Ashvarya Mangla, Estefania Oliveros, Kim Allan Williams, Dinesh K Kalra
Coronary artery disease (CAD) continues to be a leading cause of morbidity and mortality worldwide. Although invasive coronary angiography has previously been the gold standard in establishing the diagnosis of CAD, there is a growing shift to more appropriately use the cardiac catheterization laboratory to perform interventional procedures once a diagnosis of CAD has been established by noninvasive imaging modalities rather than using it primarily as a diagnostic facility to confirm or refute CAD. With ongoing technological advancements, noninvasive imaging plays a pre-eminent role in not only diagnosing CAD but also informing the choice of appropriate therapies, establishing prognosis, all while containing costs and providing value-based care...
October 2017: Current Problems in Cardiology
https://www.readbyqxmd.com/read/28867655/cosmetic-genital-surgery-in-children-and-adolescents
#15
REVIEW
Paul L Wood
Clinicians are faced with increasing requests for female cosmetic genital surgery and prominent amongst these is labiaplasty. The implications of labiaplasty in adolescence are explored with emphasis on what is known about normal genital appearances, pubertal development, anatomy and physiology and the options for surgical intervention including risks and implications. Faced with what is known to date on female cosmetic genital surgery then such interventions should be avoided in adolescence in the absence of defined medical indications until at least the age of 18 years...
August 11, 2017: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/28866680/on-the-value-of-reptilian-brains-to-map-the-evolution-of-the-hippocampal-formation
#16
Sam Reiter, Hua-Peng Liaw, Tracy M Yamawaki, Robert K Naumann, Gilles Laurent
Our ability to navigate through the world depends on the function of the hippocampus. This old cortical structure plays a critical role in spatial navigation in mammals and in a variety of processes, including declarative and episodic memory and social behavior. Intense research has revealed much about hippocampal anatomy, physiology, and computation; yet, even intensely studied phenomena such as the shaping of place cell activity or the function of hippocampal firing patterns during sleep remain incompletely understood...
2017: Brain, Behavior and Evolution
https://www.readbyqxmd.com/read/28864082/effects-of-aging-on-vocal-fundamental-frequency-and-vowel-formants-in-men-and-women
#17
Julie Traub Eichhorn, Raymond D Kent, Diane Austin, Houri K Vorperian
PURPOSE: This study reports data on vocal fundamental frequency (fo) and the first four formant frequencies (F1, F2, F3, F4) for four vowels produced by speakers in three adult age cohorts, in a test of the null hypothesis that there are no age-related changes in these variables. Participants were 43 men and 53 women between the ages of 20 and 92 years. RESULTS: The most consistent age-related effect was a decrease in fo for women. Significant differences in F1, F2, and F3 were vowel-specific for both sexes...
August 29, 2017: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/28860491/influence-of-pregnancy-history-on-the-vaginal-microbiome-of-pregnant-women-in-their-first-trimester
#18
Dimitrios Nasioudis, Larry J Forney, G Maria Schneider, Karol Gliniewicz, Michael France, Allison Boester, Mio Sawai, Jessica Scholl, Steven S Witkin
Pregnancy permanently alters maternal anatomy, physiology and immunity. We evaluated if the vaginal microbiome differed between women with a first or subsequent conception. Relative abundance of bacteria in the vaginal microbiome in first trimester pregnant women, 52 with their first known conception, 26 with a prior spontaneous or induced abortion but no deliveries and 77 with at least one prior birth, was determined by classifying DNA sequences from the V1-V3 region of bacterial 16 S rRNA genes. Lactobacillus crispatus was the numerically most abundant bacterium in 76...
August 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28856135/plant-science-view-on-biohybrid-development
#19
REVIEW
Tomasz Skrzypczak, Rafał Krela, Wojciech Kwiatkowski, Shraddha Wadurkar, Aleksandra Smoczyńska, Przemysław Wojtaszek
Biohybrid consists of a living organism or cell and at least one engineered component. Designing robot-plant biohybrids is a great challenge: it requires interdisciplinary reconsideration of capabilities intimate specific to the biology of plants. Envisioned advances should improve agricultural/horticultural/social practice and could open new directions in utilization of plants by humans. Proper biohybrid cooperation depends upon effective communication. During evolution, plants developed many ways to communicate with each other, with animals, and with microorganisms...
2017: Frontiers in Bioengineering and Biotechnology
https://www.readbyqxmd.com/read/28852330/femoral-iatrogenic-subtrochanteric-fatigue-fracture-risk-is-not-increased-by-placing-drill-holes-below-the-level-of-the-lesser-trochanter
#20
Andrew G Tsai, Timothy J Ashworth, Randall Marcus, Ozan Akkus
BACKGROUND: Iatrogenic subtrochanteric fractures of the femur can occur postoperatively following placement of screws in the lateral femoral cortex. Drilling holes below the lesser trochanter is generally avoided to prevent fatigue failure; however, there is little biomechanical evidence to support this recommendation. We hypothesized that hole placement below the level of the lesser trochanter will not accelerate fatigue failure compared to holes at the level of the lesser trochanter...
2017: Iowa Orthopaedic Journal
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