Norman van Rhijn, Can Zhao, Narjes Al-Furaji, Isabelle Storer, Clara Valero, Sara Gago, Harry Chown, Clara Baldin, Rachael Fortune-Grant, Hajer Bin Shuraym, Lia Ivanova, Olaf Kniemeyer, Thomas Krüger, Elaine Bignell, Gustavo Goldman, Jorge Amich, Daniela Delneri, Paul Bowyer, Axel Brakhage, Hubertus Haas, Michael Bromley
More than 10 million people suffer from lung diseases caused by the pathogenic fungus Aspergillus fumigatus . The azole class of antifungals represent first line therapeutics for most of these infections however resistance is rising. Identification of novel antifungal targets that, when inhibited, synergise with the azoles will aid the development of agents that can improve therapeutic outcomes and supress the emergence of resistance. As part of the A. fumigatus genome-wide knockout program (COFUN), we have completed the generation of a library that consists of 120 genetically barcoded null mutants in genes that encode the protein kinase cohort of A...
May 30, 2023: Research Square