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https://www.readbyqxmd.com/read/30516353/renal-resistive-index-predicts-post-bariatric-surgery-renal-outcome-in-nondiabetic-individuals-with-severe-obesity
#1
Anna Solini, Marta Seghieri, Eleonora Santini, Livia Giannini, Edoardo Biancalana, Stefano Taddei, Duccio Volterrani, Rosa Maria Bruno
OBJECTIVE: Bariatric surgery may ameliorate renal function through vascular mechanisms. This study tested surgery's ability to improve measured glomerular filtration rate (mGFR) and identified clinical, renal, and systemic vascular predictors of such improvement. METHODS: Twenty-five nondiabetic subjects with severe obesity were studied before and 1 year after Roux-en-Y gastric bypass, evaluating mGFR and renal plasma flow, basal renal resistive index (RI) and dynamic renal RI, renal visceral fat, and systemic vascular parameters, including flow-mediated dilation, aortic pulse wave velocity, and carotid intima media thickness and stiffness...
December 5, 2018: Obesity
https://www.readbyqxmd.com/read/30515432/serum-albumin-is-associated-with-higher-inflammation-and-carotid-atherosclerosis-in-treated-human-immunodeficiency-virus-infection
#2
Sahera Dirajlal-Fargo, Manjusha Kulkarni, Emily Bowman, Lingpeng Shan, Abdus Sattar, Nicholas Funderburg, Grace A McComsey
Background: This study was conducted to explore the associations between serum albumin and markers of inflammation and cardiovascular disease in treated human immunodeficiency virus (HIV)-infected adults. Methods: We conducted a nested study within in the SATURN-HIV trial in which 147 HIV+ adults on stable antiretroviral therapy were (1) virally suppressed, (2) had a low-density lipoprotein (LDL)-cholesterol level <130 mg/dL, and (3) were randomized to 10 mg daily rosuvastatin or placebo...
November 2018: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/30509371/submaximal-exercise-blood-pressure-and-cardiovascular-structure-in-adolescence
#3
Martin G Schultz, Chloe Park, Abigail Fraser, Laura D Howe, Siana Jones, Alicja Rapala, George Davey Smith, James E Sharman, Deborah A Lawlor, Nish Chaturvedi, John Deanfield, Alun D Hughes
PURPOSE: Dynamic exercise results in increased systolic blood pressure (BP). Irrespective of resting BP, some individuals may experience exaggerated rise in systolic BP with exercise, which in adulthood is associated with risk of hypertension, and cardiovascular (CV) disease. It is unknown if exercise BP is associated with markers of CV structure during adolescence. We examined this question in a large adolescent cohort taking account of the possible confounding effect of body composition and BP status...
January 15, 2019: International Journal of Cardiology
https://www.readbyqxmd.com/read/30509325/carotid-artery-volumetric-measures-associate-with-clinical-ten-year-cardiovascular-cv-risk-scores-and-individual-traditional-cv-risk-factors-in-rheumatoid-arthritis-a-carotid-mri-feasibility-study
#4
Lesley-Anne Bissell, Bara Erhayiem, Graham Fent, Elizabeth M A Hensor, Agata Burska, Helena Donica, Sven Plein, Maya H Buch, John P Greenwood, Jacqueline Andrews
BACKGROUND: Common carotid artery intima-media thickness (CIMT), as measured by ultrasound, has utility in stratification of the accelerated cardiovascular risk seen in rheumatoid arthritis (RA); however, the technique has limitations. Carotid magnetic resonance imaging (MRI) is emerging as a useful research tool in the general population, but has yet to be applied in RA populations. Our objectives were to describe the utility of carotid artery MRI (carotid-MRI) in patients with RA in comparison to healthy controls and to describe the association with RA disease phenotype...
December 3, 2018: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/30502348/induced-trf2-deletion-leads-to-aging-vascular-phenotype-in-mice-associated-with-arterial-telomere-uncapping-senescence-signaling-and-oxidative-stress
#5
R Garrett Morgan, Ashley E Walker, Daniel W Trott, Daniel R Machin, Grant D Henson, Kelly D Reihl, Richard M Cawthon, Eros L Denchi, Yu Liu, Samuel I Bloom, Tam T Phuong, Russell S Richardson, Lisa A Lesniewski, Anthony J Donato
Age-related vascular dysfunction in large elastic and resistance arteries is associated with reductions in microvascular perfusion and elevations in blood pressure. Recent evidence indicates that telomere uncapping-induced senescence in vascular cells may be an important source of oxidative stress and vascular dysfunction in aging, but the causal relationship between these processes has yet to be elucidated. To test this important unexplored hypothesis, we measured arterial senescence signaling and oxidative stress, carotid and mesenteric artery endothelium-dependent vasodilatory capacity, markers of mesenteric microvascular perfusion and endothelial glycocalyx deterioration, and blood pressure in a novel mouse model of Cre-inducible whole body Trf2 deletion and telomere uncapping...
November 28, 2018: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/30498994/the-carotid-body-a-physiologically-relevant-germinal-niche-in-the-adult-peripheral-nervous-system
#6
REVIEW
Verónica Sobrino, Valentina Annese, Elena Navarro-Guerrero, Aida Platero-Luengo, Ricardo Pardal
Oxygen constitutes a vital element for the survival of every single cell in multicellular aerobic organisms like mammals. A complex homeostatic oxygen-sensing system has evolved in these organisms, including detectors and effectors, to guarantee a proper supply of the element to every cell. The carotid body represents the most important peripheral arterial chemoreceptor organ in mammals and informs about hypoxemic situations to the effectors at the brainstem cardiorespiratory centers. To optimize organismal adaptation to maintained hypoxemic situations, the carotid body has evolved containing a niche of adult tissue-specific stem cells with the capacity to differentiate into both neuronal and vascular cell types in response to hypoxia...
November 29, 2018: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/30488418/-nursing-care-of-patients-with-carotid-artery-stenosis-who-receive-carotid-artery-stent
#7
Shu-Fen Su, Hsuan-Yin Su, Meng-Shan Wu
Atherosclerosis, a major cause of carotid artery stenosis, has a high correlation to stroke, which may induce transient ischemic attack (TIA) and/or permanent brain damage. The main treatment of carotid artery stenosis includes medication, carotid endarterectomy (CEA), and carotid artery stenting (CAS). However, when artery stenosis becomes severe, CEA or CAS is the most-often recommended intervention. CAS, a type of revascularization, is considered less invasive than CEA and is associated with a higher successful rate...
December 2018: Hu Li za Zhi the Journal of Nursing
https://www.readbyqxmd.com/read/30484866/sdhx-gene-detection-and-clinical-phenotypic-analysis-of-multiple-paraganglioma-in-the-head-and-neck
#8
Yiming Ding, Yaru Feng, Michael Wells, Zhigang Huang, Xiaohong Chen
OBJECTIVES: The goal of this study was to detect and explore the mechanisms of the succinate dehydrogenase (SDH) complex subunit-related gene mutations in cases of multiple paraganglioma (PGL) in the head and neck. METHODS: In Beijing Tongren Hospital (Capital Medical University, Beijing, People's Republic of China) between January 2013 and February 2017, 23 cases of head and neck multiple PGL were evaluated by genetic sequencing. From these cases, four hereditary families and 10 cases with sporadic occurrences were found...
November 28, 2018: Laryngoscope
https://www.readbyqxmd.com/read/30484390/strong-stimulation-triggers-full-fusion-exocytosis-and-very-slow-endocytosis-of-the-small-dense-core-granules-in-carotid-glomus-cells
#9
Amy Tse, Andy K Lee, Noriko Takahashi, Alex Gong, Haruo Kasai, Frederick W Tse
Chemosensory glomus cells of the carotid bodies release transmitters, including ATP and dopamine mainly via the exocytosis of small dense core granules (SDCGs, vesicular diameter of ∼100 nm). Using carbon-fiber amperometry, we showed previously that with a modest uniform elevation in cytosolic Ca2+ concentration ([Ca2+ ]i of ∼0.5 µM), SDCGs of rat glomus cells predominantly underwent a "kiss-and-run" mode of exocytosis. Here, we examined whether a larger [Ca2+ ]i rise influenced the mode of exocytosis...
September 2018: Journal of Neurogenetics
https://www.readbyqxmd.com/read/30484255/resveratrol-and-1-25-dihydroxyvitamin-d-co-administration-protects-the-heart-against-d-galactose-induced-aging-in-rats-evaluation-of-serum-and-cardiac-levels-of-klotho
#10
Ali Dehghani, Zeynab Hafizibarjin, Razieh Najjari, Fatemeh Kaseb, Fatemeh Safari
The current study investigates the cooperative cardioprotective effect of calcitriol (active form of vitamin D) combined with resveratrol in a rat model of D-galactose (D.gal)-induced aging. Male Wistar rats received resveratrol (D.gal + Res), calcitriol (D.gal + Cal), or a combination of them (D.gal + Res + Cal). Intact animals served as control (Ctl). Blood pressure (BP) was recorded by cannulation of the left carotid artery. Fibrosis and cell size were assessed by Masson's trichrome and hematoxylin-eosin staining, respectively...
November 27, 2018: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/30472674/pipeline-embolization-device-treatment-of-internal-carotid-artery-terminus-aneurysms
#11
Amit Pujari, Brian Matthew Howard, Thomas P Madaelil, Susana Libhaber Skukalek, Anil K Roy, Jacques E Dion, C Michael Cawley, Jonathan A Grossberg
BACKGROUND: The pipeline embolization device (PED) is approved for the treatment of large aneurysms of the proximal internal carotid artery (ICA). Its off-label application in treating aneurysms located specifically at the ICA terminus (ICA-T) has not been studied. METHODS: We conducted a retrospective chart review of patients from 2011 to 7 treated with PEDs. Out of 365 patients, 10 patients with ICA-T aneurysms were included. Patient demographics, procedural information, follow-up imaging, and clinical assessments were recorded...
November 24, 2018: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/30471086/subclinical-atherosclerosis-in-psoriatic-disease-relation-to-endocan-tnf-%C3%AE-age-of-onset-and-body-fat
#12
Abdelaal M Elkamshoushi, Salma S Omar, Amr M El Abd, Seham Z Hassan, Eman A Sultan, Eman Abd Elkawy
BACKGROUND: Psoriasis is a common multisystem inflammatory disease with several associated comorbidities. Serological markers to detect associated subclinical atherosclerosis in psoriatic patients are needed. We aimed to study serum endocan levels in psoriasis vulgaris and its relation to severity of psoriasis, systemic inflammation, associated atherosclerosis, obesity, and the possible factors affecting its level in psoriatic patients. METHODS: This study was conducted on 30 moderate-severe psoriasis vulgaris patients and 30 healthy controls...
November 23, 2018: International Journal of Dermatology
https://www.readbyqxmd.com/read/30470212/insulin-metabolism-markers-are-predictors-of-subclinical-atherosclerosis-among-overweight-and-obese-children-and-adolescents
#13
Golaleh Asghari, Pooneh Dehghan, Parvin Mirmiran, Emad Yuzbashian, Maryam Mahdavi, Maryam Tohidi, Tirang R Neyestani, Farhad Hosseinpanah, Fereidoun Azizi
BACKGROUND: To investigate the association between markers of insulin metabolism and carotid intima-media thickness(cIMT) among overweight and obese children and adolescents. METHODS: A total of 378 children and adolescents aged from 6 to 13 years, with WHO body mass index Z-Scores ≥2 were enrolled in this study. We measured fasting serum insulin and glucose, conducted a homeostatic model assessment of insulin resistance(HOMA-IR), and calculated the quantitative insulin sensitivity check index(QUICKI)...
November 23, 2018: BMC Pediatrics
https://www.readbyqxmd.com/read/30467729/comparison-of-correlations-of-equation-derived-body-fat-percentage-and-body-mass-index-with-carotid-intima-media-thickness
#14
Manuel Fortún Landecho, Inmaculada Colina, Patricia Sunsundegui, Bruno Camarero, Jorge M Núñez-Córdoba, Óscar Beloqui
No abstract text is available yet for this article.
November 23, 2018: Acta Diabetologica
https://www.readbyqxmd.com/read/30464491/the-association-between-metabolic-syndrome-and-asymptomatic-carotid-artery-stenosis-in-menopausal-women-a-cross-sectional-study-in-a-chinese-population
#15
Bin Zhu, Lei Zhang, Xiao Ping Cheng, Lei Wang, Yue Tian, Xi Xi Li, Ying Ping Liu, Zhi Gang Zhao
Background: To examine the association of metabolic syndrome (MetS) with carotid artery stenosis (CAS), especially in menopausal women in China. Materials and methods: A cross-sectional study of menopause women aged ≥40 years were enrolled from the Jidong community of Tangshan City between 2013 and 2014 to examine the association between MetS and CAS. Logistic regression analyses were performed to analyze the association between MetS and the presence of CAS. Results: A total of 762 menopause women with mean age 59...
2018: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/30462803/is-fgf-23-an-early-indicator-of-atherosclerosis-and-cardiac-dysfunction-in-patients-with-gestational-diabetes
#16
Dilek Tuzun, Ayten Oguz, Muhammet Naci Aydin, Ergul Belge Kurutas, Onder Ercan, Murat Sahin, Velid Ünsal, Imran Ceren, Ahmet Akçay, Kamile Gul
OBJECTIVE: Fibroblast growth factor 23 (FGF-23) is a phosphorus-regulating hormone and plays a role in the pathogenesis of myocardial hypertrophy. The aim of this study was to evaluate the association of FGF-23 levels with echocardiographic parameters and insulin resistance (IR) in patients with gestational diabetes. SUBJECTS AND METHODS: Fifty-four pregnant patients with gestational diabetes mellitus (GDM) (age, 31.12 ± 5.72 years) and 33 healthy pregnant women (age, 29...
October 2018: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/30461641/a-body-shape-index-and-vascular-structure-and-function-in-spanish-adults-mark-study-a-cross-sectional-study
#17
Manuel A Gomez-Marcos, Leticia Gomez-Sanchez, Maria Carmen Patino-Alonso, Jose I Recio-Rodriguez, Marta Gomez-Sanchez, Fernando Rigo, Ruth Marti, Cristina Agudo-Conde, Rafel Ramos, Emiliano Rodriguez-Sanchez, Jose A Maderuelo-Fernandez, Luis Garcia-Ortiz
A body shape index (ABSI) has been introduced as a marker of the relationship between body composition and all-cause mortality. However, until now, the relationships between ABSI and vascular structure and function have not been evaluated. The aim of this study was to investigate the association of ABSI with vascular structure and function in Spanish adults with intermediate cardiovascular risk. This cross-sectional study analyzed the data of 2354 subjects [age, 35-74 years (median, 62.0 years [range, 56.0-67...
November 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/30459633/influence-of-exercise-mode-on-post-exercise-arterial-stiffness-and-pressure-wave-measures-in-healthy-adult-males
#18
Doris R Pierce, Kenji Doma, Hayleigh Raiff, Jonathan Golledge, Anthony S Leicht
Background: Exercise mode has been reported to be an important determinant of arterial stiffness and wave reflection changes following a brief bout of exercise with inconsistent results to date. This study examined the impact of exercise mode on arterial stiffness and pressure wave measures following acute aerobic exercise (AER), resistance exercise (RES), and a control (CON) condition with no exercise. Methods: In a randomized, cross-over, repeated measures design, 21 healthy adult males (26.7 ± 7.2 years) undertook three experimental intervention sessions: AER (30-min cycle ergometry at 70-75% maximum heart rate), RES (3 × 10 repetitions of six upper and lower body exercises at 80-90% of 10-repetition maximum) and CON (30-min seated rest)...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/30456914/evidence-for-protein-kinase-involvement-in-the-5-ht-ca-2-i-pannexin-1-signalling-pathway-in-type-ii-glial-cells-of-the-rat-carotid-body
#19
Erin M Leonard, Min Zhang, Colin A Nurse
NEW FINDINGS: What is the central question of this study? The mammalian carotid body (CB) is a peripheral chemoreceptor organ involved in O2 and CO2 /H+ homeostasis. Recent studies suggest that 5-HT, released from CB receptor cells, can stimulate adjacent glial-like type II cells, leading to a rise in intracellular Ca2+ ([ΔCa2+ i ]) and activation of ATP-permeable pannexin-1 (Panx-1) channels. The aim of this study was to elucidate the role of protein kinases in the 5-HT-[Ca2+ ]i -Panx-1 signalling pathway...
November 20, 2018: Experimental Physiology
https://www.readbyqxmd.com/read/30453117/life-course-trajectories-of-cardiovascular-risk-impact-on-atherosclerotic-and-metabolic-indicators
#20
Benjamin D Pollock, Patrick Stuchlik, Emily W Harville, Katherine T Mills, Wan Tang, Wei Chen, Lydia A Bazzano
BACKGROUND AND AIMS: In this analysis, we estimated population-level trajectory groups of life course cardiovascular risk to explore their impact on mid-life atherosclerotic and metabolic outcomes. METHODS: This prospective study followed n = 1269 Bogalusa Heart participants, each with at least 4 study visits from childhood in 1973 through adulthood in 2016. We used discrete mixture modeling to determine trajectories of cardiovascular risk percentiles from childhood to adulthood...
November 8, 2018: Atherosclerosis
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