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https://www.readbyqxmd.com/read/30325834/gene-expression-of-neurotrophins-and-their-receptors-in-keloids
#1
Rafael de Moraes Petecof, Alfredo Gragnani, Felipe Contoli Isoldi, Gibrán Elias Harcha Munoz, Samuel Marcos Ribeiro de Noronha, Silvana Aparecida Alves Corrêa, Lydia Masako Ferreira
The aim of this study was to assess gene expression of neurotrophins and their receptors in keloids. Skin samples of normal skin and keloids were obtained from patients in the control (n = 12) and keloid (n = 12) groups, respectively. Ribonucleic acid was extracted from the skin specimens, purified, evaluated by spectrophotometry, and used to synthesize complementary DNA. Real-time quantitative polymerase chain reaction analysis of 84 human neurotrophin genes and their receptors was performed. Twelve genes, including heat shock 27-kDa protein 1, gastrin-releasing peptide receptor, corticotropin-releasing hormone receptor 2, neuropeptide Y Y2 receptor, interleukin 6 signal transducer, nerve growth factor, metallothionein 3, B-cell chronic lymphocytic leukemia/lymphoma 2, cholecystokinin A receptor, persephin, galanin receptor 2, and fibroblast growth factor receptor 3, were down-regulated in keloid tissue compared with normal skin...
October 15, 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/30325771/reconstitution-of-hiv-1-reservoir-following-high-dose-chemotherapy-autologous-stem-cell-transplantation-for-lymphoma
#2
Héloïse M Delagreverie, Laurence Gerard, Antoine Chaillon, Marie Roelens, Lounes Djerroudi, Maud Salmona, Jérôme Larghero, Lionel Galicier, François Simon, Eric Oksenhendler, Hélène Moins-Teisserenc, Constance Delaugerre
OBJECTIVES: autologous stem cell transplantation following high-dose chemotherapy (HDC/ASCT) is the prime model to study the impact of HDC in HIV-1-infected participants. We analyzed the impact of HDC/ASCT on the resurgent reservoir composition and origin. DESIGN: We included retrospectively a homogenous group of HIV-1-infected patients treated for high-risk lymphoma in a reference center with consistent chemotherapy regimen. METHODS: Thirteen participants treated with HDC/ASCT from 2012 to 2015 were included...
October 15, 2018: AIDS
https://www.readbyqxmd.com/read/30324115/a-survey-on-the-role-of-interleukin-10-in-breast-cancer-a-narrative
#3
Elnaz Sheikhpour, Parisa Noorbakhsh, Elnaz Foroughi, Soudabeh Farahnak, Rezvan Nasiri, Hossein Neamatzadeh
Interleukin (IL)-10, a multifunctional immune-regulatory cytokine with both immunosuppressive and anti-angiogenic functions, is produced by immune cells including macrophages, T lymphocytes, and natural killer cells. Among other effects, IL-10 promotes tumor cell proliferation and metastasis via immunosuppression. Interleukin-10-mediated immunosuppression is aided by synthesis of tumor necrosis factor, IL-1, IL-12, and chemokines, and down regulation of the surface co-stimulatory molecules CD80 and CD86 on tumors...
October 2018: Reports of Biochemistry & Molecular Biology
https://www.readbyqxmd.com/read/30323237/focal-rosai-dorfman-disease-coexisting-with-lymphoma-in-the-same-anatomic-site-a-localized-histiocytic-proliferation-associated-with-mapk-erk-pathway-activation
#4
Sofia Garces, C Cameron Yin, Keyur P Patel, Joseph D Khoury, John T Manning, Shaoying Li, Jie Xu, Sergio Pina-Oviedo, Malisha R Johnson, Sergio González, Montserrat Molgó, Roberto Ruiz-Cordero, L Jeffrey Medeiros
Rosai-Dorfman disease is a rare histiocytic disorder shown to have gene mutations that activate the MAPK/ERK pathway in at least one-third of cases. Most patients with Rosai-Dorfman disease present with bulky lymphadenopathy or extranodal disease, but rarely Rosai-Dorfman disease is detected concomitantly with lymphoma in the same biopsy specimen. The underlying molecular mechanisms of focal Rosai-Dorfman disease occurring in the setting of lymphoma have not been investigated. We report 12 cases of Rosai-Dorfman disease and lymphoma involving the same anatomic site...
October 15, 2018: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/30321260/lymphoepithelioma-like-carcinoma-of-the-uterine-cervix-a-pathologic-study-of-eight-cases-with-emphasis-on-the-association-with-human-papillomavirus
#5
Andre Pinto, Marilyn Huang, Mehrdad Nadji
Objectives: Lymphoepithelioma-like carcinoma (LELC) of the uterine cervix is a rare tumor. The goal of this study was to evaluate a series of cases of cervical LELC and to investigate possible association with human papillomavirus (HPV) and/or Epstein-Barr virus (EBV). Methods: Immunohistochemistry for p63, p16, human leukocyte antigen-D related (HLA-DR), and B-cell lymphoma 2 (BCL-2); in situ hybridization (ISH) for EBV and HPV; and polymerase chain reaction (PCR) genotyping were performed...
October 15, 2018: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/30320990/-malignant-or-benign-hyperleukocytosis
#6
C Spilleboudt, Ph Thibaut, E Varlet, D Bron
Leukocytosis or an increase of white blood cells in the peripheral blood is a frequent anomaly. It is important to immediately distinguish if it is a benign or malignant leukocytosis and the analysis of the blood formula is the first step. The presence of abnormal cells such as blast cells is an alarm which must immediately consider the diagnosis of leukemia, and medullogram has to be performed. The presence of lymphoma cells will lead to the conclusion of lymphoproliferative disorder and the presence of myeloid precursors to a myeloproliferative disorder...
2018: Revue Médicale de Bruxelles
https://www.readbyqxmd.com/read/30320878/during-acute-graft-versus-host-disease-cd28-deletion-in-donor-cd8-but-not-cd4-t-cells-maintains-anti-leukemia-responses-in-mice
#7
Anna Uri, Fred Lühder, Thomas Kerkau, Niklas Beyersdorf
Donor lymphocyte infusions (DLI) together with allogeneic hematopoietic stem cell transplantation (allo-HSCT) are routinely used as second-line treatment for hematological malignancies. Mature T cells in the graft crucially mediate a Graft versus Leukemia (GvL) response, but also attack healthy tissues in the recipient leading to potentially life-threatening acute Graft versus Host Disease (aGvHD). Using inducible CD28 knock-out C57BL/6 mice as T cell donors we have now assessed whether CD28 costimulation of donor CD4+ and/ or CD8+ T cells is required for an efficient GvL effect after allogeneic T cell transplantation into BALB/c recipients...
October 15, 2018: European Journal of Immunology
https://www.readbyqxmd.com/read/30320530/igg4-related-intracranial-disease
#8
Shahine Goulam-Houssein, Jeffrey L Grenville, Katerina Mastrocostas, David G Munoz, Amy Lin, Aditya Bharatha, Paraskevi A Vlachou
IgG4-related disease (IgG4-RD) is a multi-organ chronic inflammatory process caused by infiltration of IgG4-positive plasma cells in one or more organs. Intracranial involvement has only recently become better recognized. Our case series adds to the growing literature on the varying presentations of intracranial IgG4 by describing the clinical and imaging findings of three patients who presented to our institution with intracranial involvement. Our first patient presented with a mass-forming IgG4 pachymeningitis mimicking a sphenoid wing meningioma, which is to our knowledge the largest mass-forming pachymeningitis published in the literature...
October 15, 2018: Neuroradiology Journal
https://www.readbyqxmd.com/read/30320374/in-vitro-analysis-of-microrna-26a-in-chronic-lymphocytic-leukemia-cells
#9
Jing Li, Chang-Kui Sun
microRNA (miRNA)‑26a‑loaded liposomes were prepared in the present study for effective treatment of leukemia. The results demonstrated that miRNA‑26a reduced the viability of chronic lymphocytic leukemia (CLL) cells in a concentration‑dependent manner. Cells treated with miRNA‑26a‑loaded liposomes exhibited increased rates of apoptosis, as determined by flow cytometry and Hoechst 33342 staining. Western blot analysis revealed an increased apoptotic effect of miRNA‑26a‑loaded liposomes compared with control...
October 10, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/30316403/living-kidney-donor-with-small-lymphocytic-lymphoma-at-the-time-of-donation-a-case-report
#10
S Tatarano, H Enokida, Y Yamada, H Nishimura, M Nakagawa
Living kidney donor guidelines recommend that donors in whom a malignancy is diagnosed should be excluded. Although preoperative screening for malignancies was performed, we experienced a case of living donor with small lymphocytic lymphoma (SLL) at the time of donation. A 53-year-old woman was referred to our hospital for a kidney donation to her son. She had no past medical history of malignancy. We screened the patient using medical examinations, but there was no obvious presence of malignancy. Although preoperative computed tomography showed a small lymph node swelling at the left renal hilum, we diagnosed it as an insignificant lymph node...
October 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/30315937/peroxiredoxin-interaction-with-the-cytoskeletal-regulatory-protein-crmp2-investigation-of-a-putative-redox-relay
#11
Paul E Pace, Alexander V Peskin, Andreas Konigstorfer, Christine J Jasoni, Christine C Winterbourn, Mark B Hampton
Hydrogen peroxide (H2 O2 ) acts as a signaling molecule in cells by oxidising cysteine residues in regulatory proteins such as phosphatases, kinases and transcription factors. It is unclear exactly how many of these proteins are specifically targeted by H2 O2 because they appear too unreactive to be directly oxidised. One proposal is that peroxiredoxins (Prxs) initially react with H2 O2 and then oxidise adjacent proteins via a thiol relay mechanism. The aim of this study was to identify constitutive interaction partners of Prx2 in Jurkat T-lymphoma cells, in which thiol protein oxidation occurs at low micromolar concentrations of H2 O2 ...
October 10, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/30315239/updated-results-from-the-phase-3-helios-study-of-ibrutinib-bendamustine-and-rituximab-in-relapsed-chronic-lymphocytic-leukemia-small-lymphocytic-lymphoma
#12
G Fraser, P Cramer, F Demirkan, R Santucci Silva, S Grosicki, A Pristupa, A Janssens, J Mayer, N L Bartlett, M-S Dilhuydy, H Pylypenko, J Loscertales, A Avigdor, S Rule, D Villa, O Samoilova, P Panagiotidis, A Goy, M A Pavlovsky, C Karlsson, M Hallek, M Mahler, M Salman, S Sun, C Phelps, S Balasubramanian, A Howes, A Chanan-Khan
We report follow-up results from the randomized, placebo-controlled, phase 3 HELIOS trial of ibrutinib+bendamustine and rituximab (BR) for previously treated chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL) without deletion 17p. Overall, 578 patients were randomized 1:1 to either ibrutinib (420 mg daily) or placebo, in combination with 6 cycles of BR, followed by ibrutinib or placebo alone. Median follow-up was 34.8 months (range: 0.1-45.8). Investigator-assessed median progression-free survival (PFS) was not reached for ibrutinib+BR, versus 14...
October 12, 2018: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/30313065/richter-s-syndrome-of-the-central-nervous-system-diagnosed-concurrently-with-chronic-lymphocytic-leukaemia-a-case-report-and-literature-review
#13
Liye Xu, Jin Cheng Song, Xiu Hua Sun, Zi Fen Gao, Li Lv, Jie Zhu
RATIONALE: Central nervous system (CNS) infiltration of Richter's syndrome (RS) is rare and only a few cases were discussed. Of these published cases, either they were accompanied with lymph node involvement or with a history of chronic lymphocytic leukemia (CLL). To our knowledge, this is the first published case of RS of the brain and meninges diagnosed concurrently with CLL in the absence of any evidence of lymphoma outside of the CNS. PATIENT CONCERNS: A 67-year-old female presented with slurred speech, headache, and left-sided hemiparesis...
October 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/30309853/ccr5-antagonism-by-maraviroc-inhibits-hodgkin-lymphoma-microenvironment-interactions-and-xenograft-growth
#14
Naike Casagrande, Cinzia Borghese, Lydia Visser, Maurizio Mongiat, Alfonso Colombatti, Donatella Aldinucci
Classic Hodgkin lymphoma tumor cells express a functional CCR5 receptor, and tumor tissues express high CCL5 levels, suggesting that CCL5-CCR5 signaling is involved in tumor-microenvironment formation and tumor growth. Using the CCR5 antagonist maraviroc and a neutralizing anti-CCL5 antibody, we found that CCL5 secreted by Classic Hodgkin lymphoma cells recruited Mesenchymal-stromal cells and monocytes. Education of Mesenchymal-stromal cells by tumor cell conditioned medium enhanced Mesenchymal-stromal cells proliferation and CCL5 secretion...
October 11, 2018: Haematologica
https://www.readbyqxmd.com/read/30306871/proteolysis-targeting-chimera-protac-a-paradigm-shifting-approach-in-small-molecule-drug-discovery
#15
Pingyuan Wang, Jia Zhou
Great success has been achieved in small molecule drug discovery programs, making extraordinary contributions for human health, especially in targeted therapy. Taking anticancer drug discovery as an example, small molecules traditionally inhibit the target protein enzyme activities and induce cancer cell apoptosis through the target binding. However, the target protein within tumor cells often recovers its activities, leading to acquired drug-resistance through the overexpression of the target protein or the generation of new mutations in the target protein [1]...
October 9, 2018: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/30305106/feline-low-grade-alimentary-lymphoma-an-emerging-entity-and-a-potential-animal-model-for-human-disease
#16
Mathieu V Paulin, Lucile Couronné, Jérémy Beguin, Sophie Le Poder, Maxence Delverdier, Marie-Odile Semin, Julie Bruneau, Nadine Cerf-Bensussan, Georgia Malamut, Christophe Cellier, Ghita Benchekroun, Laurent Tiret, Alexander J German, Olivier Hermine, Valérie Freiche
BACKGROUND: Low-grade alimentary lymphoma (LGAL) is characterised by the infiltration of neoplastic T-lymphocytes, typically in the small intestine. The incidence of LGAL has increased over the last ten years and it is now the most frequent digestive neoplasia in cats and comprises 60 to 75% of gastrointestinal lymphoma cases. Given that LGAL shares common clinical, paraclinical and ultrasonographic features with inflammatory bowel diseases, establishing a diagnosis is challenging. A review was designed to summarise current knowledge of the pathogenesis, diagnosis, prognosis and treatment of feline LGAL...
October 11, 2018: BMC Veterinary Research
https://www.readbyqxmd.com/read/30302434/perforation-of-the-small-intestine-caused-by-enteropathy-associated-t-cell-lymphoma
#17
Selva Kabul, Nesrin Uğraş, Ömer Yerci, Ersin Öztürk
Enteropathy-associated T cell lymphoma is a rare lymphoma specific to the gastrointestinal system, arising from intraepithelial T lymphocytes, that is often associated with celiac disease. We report a 53-year-old female patient with no previous disease who presented with severe abdominal pain. Physical examination revealed diffuse abdominal tenderness and abdominal guarding and the patient underwent emergency surgery with a diagnosis of acute abdomen. During the operation, a 20-cm mass was found located on Treitz ligament, invading the duodenum and pancreatic head and perforating the jejunum...
2018: Turkish Journal of Surgery
https://www.readbyqxmd.com/read/30301728/two-distinct-histological-richter-s-transformations-23-years-apart-in-a-patient-with-chronic-lymphocytic-leukaemia
#18
Umera Thebo, Ralph Linwood Millett, Jacob Elkon, Faysal Haroun
A 53-year-old man with a 1-year history of chronic lymphocytic leukaemia (CLL) presented with a left bicep mass. Biopsy and staging workup revealed Richter's transformation (RT) Ann Arbor stage 1E diffuse large B-cell lymphoma in the bicep. The patient was treated with combination chemotherapy with cyclophosphamide, doxorubicin, Vincristine and prednisone followed by site radiation and did well thereafter. His CLL progressed and required treatment on two more occasions 11 and 18 years after his initial diagnosis with fludarabine, Cytoxan and Rituxan and then with bendamustine and rituximab...
October 8, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/30300581/enhanced-anti-lymphoma-activity-of-car19-inkt-cells-underpinned-by-dual-cd19-and-cd1d-targeting
#19
Antonia Rotolo, Valentina S Caputo, Monika Holubova, Nicoleta Baxan, Olivier Dubois, Mohammed Suhail Chaudhry, Xiaolin Xiao, Katerina Goudevenou, David S Pitcher, Kyriaki Petevi, Carolina Kachramanoglou, Sandra Iles, Kikkeri Naresh, John Maher, Anastasios Karadimitris
Chimeric antigen receptor anti-CD19 (CAR19)-T cell immunotherapy-induced clinical remissions in CD19+ B cell lymphomas are often short lived. We tested whether CAR19-engineering of the CD1d-restricted invariant natural killer T (iNKT) cells would result in enhanced anti-lymphoma activity. CAR19-iNKT cells co-operatively activated by CD1d- and CAR19-CD19-dependent interactions are more effective than CAR19-T cells against CD1d-expressing lymphomas in vitro and in vivo. The swifter in vivo anti-lymphoma activity of CAR19-iNKT cells and their enhanced ability to eradicate brain lymphomas underpinned an improved tumor-free and overall survival...
October 8, 2018: Cancer Cell
https://www.readbyqxmd.com/read/30291474/macaca-arctoides-gammaherpesvirus-1-strain-herpesvirus-macaca-arctoides-virus-sequence-phylogeny-and-characterisation-of-virus-transformed-macaque-and-rabbit-cell-lines
#20
Andi Krumbholz, Janine Roempke, Thomas Liehr, Marco Groth, Astrid Meerbach, Michael Schacke, Gregor Maschkowitz, Helmut Fickenscher, Wolfram Klapper, Andreas Sauerbrei, Peter Wutzler, Roland Zell
Herpesvirus Macaca arctoides (HVMA) has the propensity to transform macaque lymphocytes to lymphoblastoid cells (MAL-1). Inoculation of rabbits with cell-free virus-containing supernatant resulted in the development of malignant lymphomas and allowed isolation of immortalised HVMA-transformed rabbit lymphocytes (HTRL). In this study, the HVMA genome sequence (approx. 167 kbp), its organisation, and novel aspects of virus latency are presented. Ninety-one open reading frames were identified, of which 86 were non-repetitive...
October 5, 2018: Medical Microbiology and Immunology
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