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https://www.readbyqxmd.com/read/30107547/maternal-nutrient-restriction-alters-uterine-artery-hemodynamics-and-placentome-vascular-density-in-bos-indicus-and-bos-taurus
#1
Caleb O Lemley, Caitlin G Hart, Racheal L Lemire, E Heath King, Richard M Hopper, Seong B Park, Brian J Rude, Derris D Burnett
The objective was to examine uterine artery blood flow (UBF) as well as macroscopic and microscopic placentome vascular density in nutrient restricted Angus and Brahman heifers. Angus (n = 6) and Brahman (n = 6) heifers were bred to a single sire and pregnancy confirmed at 30 days post-breeding. Heifers were randomly assigned to one of two dietary treatments consisting of 100% (control fed; CON; n = 6) or 60% (total nutrient restricted; RES; n = 6) based from net energy requirements for gestating heifers. Nutritional treatments were imposed from day 50 to 180 of gestation...
August 13, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/30106447/long-non%C3%A2-coding-rnas-in-small-cell-lung-cancer-a-potential-opening-to-combat-the-disease-review
#2
Tian-Tian Li, Rong-Quan He, Jie Ma, Zu-Yun Li, Xiao-Hua Hu, Gang Chen
Lung cancer is the top cause of cancer‑associated mortality in men and women worldwide. Small cell lung cancer (SCLC) is a subtype that constitutes ~15% of all lung cancer cases. Long non‑coding RNAs (lncRNAs), possessing no or limited protein‑coding ability, have gained extensive attention as a potentially promising avenue by which to investigate the biological regulation of human cancer. lncRNAs can modulate gene expression at the transcriptional, post‑transcriptional and epigenetic levels. The current review highlights the developing clinical implications and functional roles of lncRNAs in SCLC, and provides directions for their future utilization in the diagnosis and treatment of SCLC...
August 7, 2018: Oncology Reports
https://www.readbyqxmd.com/read/30106440/set7-9-promotes-hepatocellular-carcinoma-progression-through-regulation-of-e2f1
#3
Ye Gu, Xinling Wang, Hong Liu, Guimei Li, Weiping Yu, Qing Ma
Hepatocellular carcinoma (HCC) is one of the most prevalent malignancies worldwide. Histone‑lysine N‑methyltransferase SET7/9 is a protein lysine monomethylase that methylates histone H3K4 as well as various non‑histone proteins. Deregulation of SET7/9 is frequently detected in human cancers. However, the role of SET7/9 in HCC development remains unclear. In the present study, upregulation of SET7/9 and E2F transcription factor 1 (E2F1) expression was detected in 68 samples of HCC tissues compared with these levels noted in the paired healthy liver samples...
August 2, 2018: Oncology Reports
https://www.readbyqxmd.com/read/30106353/dissecting-candida-pathobiology-post-translational-modifications-on-the-candida-tropicalis-proteome
#4
Arun H Patil, Keshava K Datta, Santosh Kumar Behera, Sandeep Kasaragod, Sneha M Pinto, Shashanka G Koyangana, Premendu P Mathur, Harsha Gowda, Akhilesh Pandey, Thottethodi Subrahmanya Keshava Prasad
Candida tropicalis belongs to the non-albicans group of Candida, and causes epidermal, mucosal, or systemic candidiasis in immunocompromised individuals. Although the prevalence of candidiasis has increased worldwide and non-albicans Candida (NAC) are becoming more significant, there are very few studies that focus on the NAC biology. Proteins and their post-translational modifications (PTMs) are an integral aspect in the pathobiology of such medically important fungi. Previously, we had reported the largest proteomic catalog of C...
August 2018: Omics: a Journal of Integrative Biology
https://www.readbyqxmd.com/read/30106054/-xuefu-zhuyu-decoction-improves-neurological-dysfunction-by-increasing-synapsin-expression-after-traumatic-brain-injury
#5
Lin Zhu, Tao Tang, Rong Fan, Jie-Kun Luo, Han-Jin Cui, Chun-Hu Zhang, Wei-Jun Peng, Peng Sun, Xin-Gui Xiong, Yang Wang
Xuefu Zhuyu decoction has been used for treating traumatic brain injury and improving post-traumatic dysfunction, but its mechanism of action needs further investigation. This study established rat models of traumatic brain injury by controlled cortical impact. Rat models were intragastrically administered 9 and 18 g/kg Xuefu Zhuyu decoction once a day for 14 or 21 days. Changes in neurological function were assessed by modified neurological severity scores and the Morris water maze. Immunohistochemistry, western blot assay, and reverse-transcription polymerase chain reaction were used to analyze synapsin protein and mRNA expression at the injury site of rats...
August 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/30105952/integration-of-omics-techniques-dronedarone-affects-cardiac-remodeling-in-the-infarction-border-zone
#6
Ravi K Chilukoti, Josefine Lendeckel, Katrin Darm, Alicja Bukowska, Andreas Goette, Marc Sühling, Kirsten Utpatel, Barbara Peters, Georg Homuth, Uwe Völker, Carmen Wolke, Christian Scharf, Uwe Lendeckel
Dronedarone improves microvascular flow during atrial fibrillation and reduces the infarct size in acute models of myocardial infarction. However, dronedarone might be harmful in patients with recent decompensated heart failure and increases mortality in patients with permanent atrial fibrillation. A pathophysiological explanation for these discrepant data is lacking. This study investigated the effects of dronedarone on gene and protein expression in the infarcted area and border zone in pigs subjected to anterior ischemia/reperfusion myocardial infarction...
July 2018: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/30105802/proteomics-clinical-and-research-applications-in-respiratory-diseases
#7
REVIEW
Katy C Norman, Bethany B Moore, Kelly B Arnold, David N O'Dwyer
The proteome is the study of the protein content of a definable component of an organism in biology. However, the tissue-specific expression of proteins and the varied post-translational modifications, splice variants and protein-protein complexes that may form, make the study of protein a challenging yet vital tool in answering many of the unanswered questions in medicine and biology to date. Indeed, the spatial, temporal and functional composition of proteins in the human body has proven difficult to elucidate for many years...
August 13, 2018: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/30105735/the-expression-levels-of-il-4-il-13-stat6-signaling-pathway-genes-and-socs3-could-help-to-differentiate-the-histopathological-subtypes-of-non-small-cell-lung-carcinoma
#8
Dorota Pastuszak-Lewandoska, Daria Domańska-Senderowska, Adam Antczak, Jacek Kordiak, Paweł Górski, Karolina H Czarnecka, Monika Migdalska-Sęk, Ewa Nawrot, Justyna M Kiszałkiewicz, Ewa Brzeziańska-Lasota
BACKGROUND: The interleukin (IL)-4/IL-13/signal transducer and activator of transcription (STAT) 6 signaling pathway and the SOCS3 gene, one of its main regulators, constitute an important link between the inflammation process in the epithelial cells and inflammatory-related tumorigenesis. The present study is the first to evaluate IL-4, IL-13, STAT6, and SOCS3 mRNA expression in non-small cell lung carcinoma (NSCLC) histopathological subtypes. METHODS: Gene expression levels were assessed using TaqMan® probes by quantitative reverse transcription PCR (qRT-PCR) in lung tumor samples and unchanged lung tissue samples...
August 13, 2018: Molecular Diagnosis & Therapy
https://www.readbyqxmd.com/read/30105226/molecular-basis-of-human-sperm-capacitation
#9
REVIEW
Lis C Puga Molina, Guillermina M Luque, Paula A Balestrini, Clara I Marín-Briggiler, Ana Romarowski, Mariano G Buffone
In the early 1950s, Austin and Chang independently described the changes that are required for the sperm to fertilize oocytes in vivo . These changes were originally grouped under name of "capacitation" and were the first step in the development of in vitro fertilization (IVF) in humans. Following these initial and fundamental findings, a remarkable number of observations led to characterization of the molecular steps behind this process. The discovery of certain sperm-specific molecules and the possibility to record ion currents through patch-clamp approaches helped to integrate the initial biochemical observation with the activity of ion channels...
2018: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/30104667/the-landscape-of-the-a-to-i-rna-editome-from-462-human-genomes
#10
Zhangyi Ouyang, Chao Ren, Feng Liu, Gaole An, Xiaochen Bo, Wenjie Shu
A-to-I editing, as a post-transcriptional modification process mediated by ADAR, plays a crucial role in many biological processes in metazoans. However, how and to what extent A-to-I editing diversifies and shapes population diversity at the RNA level are largely unknown. Here, we used 462 mRNA-sequencing samples from five populations of the Geuvadis Project and identified 16,518 A-to-I editing sites, with false detection rate of 1.03%. These sites form the landscape of the RNA editome of the human genome...
August 13, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30104286/cdk12-an-emerging-therapeutic-target-for-cancer
#11
Goldie Y L Lui, Carla Grandori, Christopher J Kemp
Cyclin-dependent kinase 12 (CDK12) belongs to the cyclin-dependent kinase (CDK) family of serine/threonine protein kinases that regulate transcriptional and post-transcriptional processes, thereby modulating multiple cellular functions. Early studies characterised CDK12 as a transcriptional CDK that complexes with cyclin K to mediate gene transcription by phosphorylating RNA polymerase II. CDK12 has been demonstrated to specifically upregulate the expression of genes involved in response to DNA damage, stress and heat shock...
August 13, 2018: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/30103742/altered-mirna-profile-in-testis-of-post-cryptorchidopexy-patients-with-non-obstructive-azoospermia
#12
Dongdong Tang, Zhenyu Huang, Xiaojin He, Huan Wu, Dangwei Peng, Li Zhang, Xiansheng Zhang
BACKGROUND: Cryptorchidism is one of the most common causes of non-obstructive azoospermia (NOA) leading to male infertility. Despite various medical approaches been utilised, many patients still suffer from infertility. MicroRNAs (miRNAs) play vital roles in the progress of spermatogenesis; however, little is known about the miRNA expression profile in the testes. Therefore, the miRNA profile was assessed in the testis of post-cryptorchidopexy patients. METHODS: Three post-cryptorchidopexy testicular tissue samples from patients aged 23, 26 and 28 years old and three testis tissues from patients with obstructive azoospermia (controls) aged 24, 25 and 36 years old were used in this study...
August 13, 2018: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/30103673/identification-and-characterization-of-ncrna-associated-cerna-networks-in-arabidopsis-leaf-development
#13
Xianwen Meng, Peijing Zhang, Qi Chen, Jingjing Wang, Ming Chen
BACKGROUND: Leaf development is a complex biological process that is accompanied by wide transcriptional changes. Many protein-coding genes have been characterized in plant leaves, but little attention has been given to noncoding RNAs (ncRNAs). Moreover, increasing evidence indicates that an intricate interplay among RNA species, including protein-coding RNAs and ncRNAs, exists in eukaryotic transcriptomes, however, it remains elusive in plant leaves. RESULTS: We detected novel ncRNAs, such as circular RNAs (circRNAs) and long noncoding RNAs (lncRNAs), and further constructed and analyzed their associated competitive endogenous RNA (ceRNA) networks in Arabidopsis leaves...
August 13, 2018: BMC Genomics
https://www.readbyqxmd.com/read/30103495/micrornas-in-cardiac-autophagy-small-molecules-and-big-role
#14
REVIEW
Teng Sun, Meng-Yang Li, Pei-Feng Li, Ji-Min Cao
Autophagy, which is an evolutionarily conserved process according to the lysosomal degradation of cellular components, plays a critical role in maintaining cell homeostasis. Autophagy and mitochondria autophagy (mitophagy) contribute to the preservation of cardiac homeostasis in physiological settings. However, impaired or excessive autophagy is related to a variety of diseases. Recently, a close link between autophagy and cardiac disorders, including myocardial infarction, cardiac hypertrophy, cardiomyopathy, cardiac fibrosis, and heart failure, has been demonstrated...
August 11, 2018: Cells
https://www.readbyqxmd.com/read/30103412/the-methylation-status-of-the-epigenome-its-emerging-role-in-the-regulation-of-tumor-angiogenesis-and-tumor-growth-and-potential-for-drug-targeting
#15
REVIEW
Luciano Pirola, Oskar Ciesielski, Aneta Balcerczyk
Approximately 50 years ago, Judah Folkman raised the concept of inhibiting tumor angiogenesis for treating solid tumors. The development of anti-angiogenic drugs would decrease or even arrest tumor growth by restricting the delivery of oxygen and nutrient supplies, while at the same time display minimal toxic side effects to healthy tissues. Bevacizumab (Avastin)-a humanized monoclonal anti VEGF-A antibody-is now used as anti-angiogenic drug in several forms of cancers, yet with variable results. Recent years brought significant progresses in our understanding of the role of chromatin remodeling and epigenetic mechanisms in the regulation of angiogenesis and tumorigenesis...
August 10, 2018: Cancers
https://www.readbyqxmd.com/read/30102938/genetic-association-between-hla-g-14-bp-polymorphism-and-diseases-a-systematic-review-and-meta-analysis
#16
Bibiana Sgorla de Almeida, Yara Costa Netto Muniz, Alice Heidrich Prompt, Erick C Castelli, Celso Teixeira Mendes-Junior, Eduardo Antonio Donadi
BACKGROUND: HLA-G is an immune checkpoint molecule. Since a differential molecule expression has been reported even for healthy individuals, many studies have focused on polymorphisms at HLA-G regulatory regions, particularly the 3' untranslated region (3'UTR). The presence/absence of a 14-bp sequence was the first polymorphism described and it is the most studied in association between HLA-G and disorders. METHODS: In this study, we performed a systematic review and meta-analysis of all association studies published regarding the HLA-G 14-bp...
August 10, 2018: Human Immunology
https://www.readbyqxmd.com/read/30102929/microrna-in-lung-cancer-role-mechanisms-pathways-and-therapeutic-relevance
#17
REVIEW
Mohammad Askandar Iqbal, Shweta Arora, Gopinath Prakasam, George A Calin, Mansoor Ali Syed
Lung cancer is the cardinal cause of cancer-related deaths with restricted recourse of therapy throughout the world. Clinical success of therapies is not very promising due to - late diagnosis, limited therapeutic tools, relapse and the development of drug resistance. Recently, small ∼20-24 nucleotides molecules called microRNAs (miRNAs) have come into the limelight as they play outstanding role in the process of tumorigenesis by regulating cell cycle, metastasis, angiogenesis, metabolism and apoptosis. miRNAs essentially regulate gene expression via post-transcriptional regulation of mRNA...
August 10, 2018: Molecular Aspects of Medicine
https://www.readbyqxmd.com/read/30102779/spinalization-and-locomotor-training-differentially-affect-muscarinic-acetylcholine-receptor-type-2-abutting-on-%C3%AE-motoneurons-innervating-the-ankle-extensor-and-flexor-muscles
#18
Angelika Więckowska, Olga Gajewska-Woźniak, Anna Głowacka, Benjun Ji, Kamil Grycz, Julita Czarkowska-Bauch, Małgorzata Skup
Complete thoracic spinal cord transection (SCT) impairs excitatory cholinergic inputs to ankle extensor (Soleus; Sol) but not to flexor (Tibialis Anterior; TA) α-motoneurons (MNs) modifiable by locomotor training applied post-transection. The purpose of this study was to investigate whether Sol and TA MNs adapt to changes in cholinergic environment by differential regulation of their muscarinic receptors M2 (M2R). We examined Chrm2 (M2R gene) transcript level, high-affinity [3 H]QNB ligand binding, distribution and density of M2R immunolabeling in lumbar (L) segments in intact and SCT rats, with or without inclusion of 5-week treadmill locomotor training...
August 13, 2018: Journal of Neurochemistry
https://www.readbyqxmd.com/read/30102404/a-pirna-utilizes-hili-and-hiwi2-mediated-pathway-to-down-regulate-ferritin-heavy-chain-1-mrna-in-human-somatic-cells
#19
Sumirtha Balaratnam, Nicole West, Soumitra Basu
The piwi interacting RNAs (piRNAs) are small non-coding RNAs that specifically bind to the PIWI proteins, a functional requirement. The piRNAs regulate germline development, transposons control, and gene expression. However, piRNA-mediated post-transcriptional gene regulation in human somatic cells is not well understood. We discovered a human piRNA (piR-FTH1) which has a complementary sequence in the ferritin heavy chain 1 (Fth1) mRNA. We demonstrated that expression of piR-FTH1 and Fth1 are inversely correlated in the tested tumor cell lines...
August 9, 2018: Nucleic Acids Research
https://www.readbyqxmd.com/read/30102398/facer-comprehensive-molecular-and-functional-characterization-of-epigenetic-chromatin-regulators
#20
Jianping Lu, Juan Xu, Junyi Li, Tao Pan, Jing Bai, Liqiang Wang, Xiyun Jin, Xiaoyu Lin, Yunpeng Zhang, Yongsheng Li, Nidhi Sahni, Xia Li
Epigenetic alterations, a well-recognized cancer hallmark, are driven by chromatin regulators (CRs). However, little is known about the extent of CR deregulation in cancer, and less is known about their common and specialized roles across various cancers. Here, we performed genome-wide analyses and constructed molecular signatures and network profiles of functional CRs in over 10 000 tumors across 33 cancer types. By integration of DNA mutation, genome-wide methylation, transcriptional/post-transcriptional regulation, and protein interaction networks with clinical outcomes, we identified CRs associated with cancer subtypes and clinical prognosis as potential oncogenic drivers...
August 8, 2018: Nucleic Acids Research
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