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brain natriuretic factor

Rufang Zhang, Jin Gong, Shouqing Wang, Li Shen, Yewei Xie, Xiaobing Li
The aim of this study was to investigate the role of B7-H3 in prognosis of congenital heart disease (CHD) children patients. A total of 65 CHD patients within age 3-12 years who went to our hospital were included during August 2011 to December 2012. Demographic data including age, sex, weight, clinical basic information such as New York Heart Association (NYHA) class, pathological type were collected. Blood samples were collected and serum levels of B7-H3, C-reactive protein (CRP), N-Terminal Pro-Brain Natriuretic Peptide (NT-pro-BNP), and High-sensitivity Troponin T (hsTnT) were determined by enzyme-linked immunosorbent assay (ELISA)...
October 17, 2018: Pediatric Cardiology
Cheng Zheng, Jia-Feng Lin, Zhong-Hao Lin, Wei-Qian Lin, Saroj Thapa, Yuan-Zheng Lin, Hao Lian, Zhi-Rui Liu, Jia-Hui Chen, Xiao-Wei Li
With the chronic ischemia persisting after acute myocardial infarction, the accompanying low-degree inflammation and subsequent fibrosis result in progression of cardiac remodeling and heart failure. Recently, Sodium Houttuyfonate (SH), a pure compound extracted from Houttuynia cordata , has been confirmed exerting anti-inflammatory and anti-fibrotic effects under diseased situations. Here, we aimed to investigate whether SH could reverse the cardiac remodeling post-myocardial infarction by alleviating cardiac inflammation and fibrosis...
2018: Frontiers in Pharmacology
Kyu Yon G Cho, Akinobu Nakamura, Kazuno Omori, Takahiro Takase, Aika Miya, Naoki Manda, Yoshio Kurihara, Shin Aoki, Tatsuya Atsumi, Hideaki Miyoshi
The effects of dapagliflozin and pioglitazone on body weight and glycemic control were compared in patients with type 2 diabetes mellitus. Seventy-one patients on pioglitazone (PIO) were either switched to dapagliflozin (DAP, n = 36) at 5 mg per day or continued on PIO (n = 35). Primary endpoints were superiority of weight loss and non-inferiority of HbA1c level after 24 weeks with DAP. Body weight decrease was greater with DAP than with PIO (75.3 ± 14.9 to 71.3 ± 15.1 kg vs. 74.7 ± 13.8 to 75.2 ± 13.9 kg; p < 0...
October 12, 2018: Diabetes, Obesity & Metabolism
June Hong Ahn, Eun Young Choi
There are several established prognostic scoring systems for community-acquired pneumonia (CAP). The Pneumonia Severity Index (PSI) is a prediction rule consisting of 20 variables to identify low-risk patients with CAP. Although PSI had high discrimination ability, it is complex to calculate and difficult to use in busy hospital settings. The CURB-65 score is much simpler to use than is PSI, but it has lower sensitivity for predicting mortality compared with PSI. The A-DROP score is a modified version of the CURB-65 score and provides similar predictive power to that of CURB-65...
October 1, 2018: Scientific Reports
Oressia Zalucki, Lachlan Harris, Tracey J Harvey, Danyon Harkins, Jocelyn Widagdo, Sabrina Oishi, Elise Matuzelski, Xuan Ling Hilary Yong, Hannes Schmidt, Victor Anggono, Thomas H J Burne, Richard M Gronostajski, Michael Piper
Understanding the migration of newborn neurons within the brain presents a major challenge in contemporary biology. Neuronal migration is widespread within the developing brain but is also important within the adult brain. For instance, stem cells within the ventricular-subventricular zone (V-SVZ) and the subgranular zone of dentate gyrus of the adult rodent brain produce neuroblasts that migrate to the olfactory bulb and granule cell layer of the dentate gyrus, respectively, where they regulate key brain functions including innate olfactory responses, learning, and memory...
October 1, 2018: Cerebral Cortex
Jing Wang, Meng-Ling Wu, Shou-Pei Cao, Hui Cai, Zhi-Ming Zhao, Yao-Hong Song
Cycloastragenol, a naturally occurring compound in Astragali Radix, has been demonstrated to possess various pharmacological actions including anti-aging, anti-inflammation, anti-fibrosis, antibacterial, liver and endothelium protection. However, whether cycloastragenol ameliorates heart failure remains unclear. Isoproterenol administration to rats triggered classic cardiac damage, as demonstrated by objective parameters of cardiac dysfunction. The treatment of cycloastragenol improved deranged cardiac parameters in the isoproterenol-induced heart damage model in a dose-dependent manner...
November 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Simei Sun, Hae Jin Kee, Li Jin, Yuhee Ryu, Sin Young Choi, Gwi Ran Kim, Myung Ho Jeong
We previously reported that gentisic acid (2,5-dihydroxybenzoic acid) is the third most abundant phenolic component of Dendropanax morbifera branch extracts. Here, we investigated its effects on cardiac hypertrophy and fibrosis in a mouse model of pressure overload and compared them to those of the beta blocker bisoprolol and calcium channel blocker diltiazem. Cardiac hypertrophy was induced in mice by transverse aortic constriction (TAC). Beginning 2 weeks after this procedure, the mice were given daily intraperitoneal injections of gentisic acid (100 mg/kg/d), bisoprolol (5 mg/kg/d) or diltiazem (10 mg/kg/d) for 3 weeks...
September 6, 2018: Journal of Cellular and Molecular Medicine
Vasiliki Katsi, Maria Marketou, Alexios S Antonopoulos, Dimitrios Vrachatis, Fragkiskos Parthenakis, Dimitris Tousoulis
Obesity is a major risk factor for the development of chronic heart failure (CHF) and does not only pose diagnostic challenges, but also has prognostic implications for these patients. Paradoxically, obese patients with CHF have a better prognosis than thinner individuals. In recent years, it has been demonstrated that the adipose tissue, even in patients with HF, is not always detrimental, and that obesity may coexist with a phenotype of benign adiposity without systemic metabolic abnormalities. Experimental data have shown that natriuretic peptides (NPs), and in particular brain natriuretic peptide (BNP), play a major role in the communication of the heart with the adipose tissue...
September 25, 2018: Heart Failure Reviews
Bei-Lei Liu, Mian Cheng, Shan Hu, Shun Wang, Le Wang, Zheng-Qing Hu, Cong-Xin Huang, Hong Jiang, Gang Wu
Background: Shensong Yangxin Capsule (SSYX), traditional Chinese medicine, has been used to treat arrhythmias, angina, cardiac remodeling, cardiac fibrosis, and so on, but its effect on cardiac energy metabolism is still not clear. The objective of this study was to investigate the effects of SSYX on myocardium energy metabolism in angiotensin (Ang) II-induced cardiac hypertrophy. Methods: We used 2 μl (10-6 mol/L) AngII to treat neonatal rat cardiomyocytes (NRCMs) for 48 h...
October 5, 2018: Chinese Medical Journal
Bangdang Chen, Xiaocui Chen, Cheng Liu, Jihong Li, Fen Liu, Ying Huang
Mesenchymal stem cells (MSCs) transplantation has emerged as a promising therapeutic strategy for acute myocardial infarction. However, there are still limitations for this therapy, such as low survival rate and poor cardiac differentiation potential of MSCs. In this study, we genetically engineered MSCs using ex vivo adeno-associated virus (AAV) transduction to overexpress Akt1 and Wnt11, which are well-characterized genes involved in MSC proliferation and cardiac differentiation. Our results showed that infection with AAV-Akt1-Wnt11 significantly upregulated the growth and proliferation of MSCs, as compared with those infected with AAV-Akt1 or AAV-Wnt11...
September 19, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Entsar R Mokhtar, Eman M, Maha A Hassan, Hanaa A Abou-ELHassan, Mona G Alanany, Mohammed A Hasuna
Renal dysfunction is a key risk factor for all-cause mortality in patients with type 2 diabetes (T2D). Special attention has been raised regarding the role of soluble tumor necrosis factor receptor1 (sTNFR1) and brain natriuretic peptide (BNP) in diabetic nephropathy (DN) since they play a crucial role in the pathogenesis of T2D complications. Elevated concentrations of sTNFR1and BNP were found to be associated with progression to end stage renal disease (ESRD) in T2D. We determined serum levels of sTNFR1 and BNP in T2D patients and correlated them with various clinical variables especially kidney function and urinary albumin creatinine ratio (UACR)...
January 2018: Egyptian Journal of Immunology
Wilma Noia Ribeiro, Alice Tatsuko Yamada, Cesar José Grupi, Gisela Tunes da Silva, Alfredo Jose Mansur
BACKGROUND: Premature complexes are common electrocardiographic findings in daily clinical practice that require further evaluation. Investigation may sometimes be complex and expensive. The aim of our study was to analyze variables associated with premature beats identified in outpatients referred from a primary care facility. MATERIALS AND METHODS: We performed a cross-sectional study of 407 outpatients (aged 55.8±11years; 56% women) who were followed by general practitioners and were referred for resting 12-lead electrocardiograms for a routine clinical follow-up...
2018: PloS One
Shu-Chun Kuo, Yingxiao Li, Yung-Ze Cheng, Wei-Jing Lee, Juei-Tang Cheng, Kai-Chun Cheng
Cardiac hypertrophy is commonly involved in cardiac injury. Oxidative stress can induce cardiac hypertrophy with apoptosis. Potassium bromate (KBrO3) has been widely used as a food additive due to its oxidizing properties. In the present study, the rat‑derived heart cell line H9c2 was used to investigate the effect of KBrO3 on cell size. KBrO3 increased cell size at concentrations <250 µM, in a dose‑dependent manner. Additionally, KBrO3 also promoted the gene expression of two biomarkers of cardiac hypertrophy, brain/B‑type natriuretic peptides (BNP) and β‑Myosin Heavy Chain (β‑MHC)...
September 10, 2018: Molecular Medicine Reports
Guangjun Jin, Zhu Chen, Jiancheng Zhang, Jia Song, Jun Shi, Bingzhi Zhou
Objective: To examine the association between brain natriuretic peptide (BNP) gene single nucleotide polymorphisms (SNPs) and chronic obstructive pulmonary disease (COPD) and COPD with pulmonary hypertension (PH) and to analyze its mechanism. Methods: The genotypes of BNP at the rs198389, rs6668352, and rs198388 loci in 339 patients with COPD (205 in the COPD/PH- group and 134 in the COPD/PH+ group) and 125 healthy subjects were detected by PCR/Sanger sequencing. The serum levels of BNP, fibrinogen (Fbg), and Apelin were measured in all subjects by ELISA...
October 31, 2018: Bioscience Reports
Maria Härstedt, Anna Holmberg, Cecilia Rogmark, Richard Sutton, Olle Melander, Viktor Hamrefors, Artur Fedorowski
BACKGROUND: Low-energy fractures are a growing health challenge as their incidence increases with advancing age. As cardiovascular instability may be associated with higher likelihood of traumatic falls, we aimed to investigate the associations between four cardiovascular biomarkers and the risk of low-energy fractures in a middle-aged population. METHODS: A total of 5291 individuals from the prospective Malmö Diet and Cancer (MDC) study (mean age, 57 years; 59% women) with data on baseline levels of four cardiovascular biomarkers: mid-regional-fragment of pro-adrenomedullin-peptide (MR-pro-ADM), mid-regional-fragment of pro-atrial-natriuretic-peptide (MR-proANP), N-terminal pro-brain natriuretic peptide (NT-pro-BNP) and C-terminal-pro-arginine-vasopressin (CT-pro-AVP/Copeptin) were included...
2018: PloS One
Ramsha Iqbal, Md Sayeed Akhtar, Md Quamrul Hassan, Zeeba Jairajpuri, Mohd Akhtar, Abul Kalam Najmi
Pitavastatin inhibits 3 hydroxy 3 methyl glutaryl coenzyme A (HMGCoA) reductase enzyme, preventing cholesterol synthesis along with elevating high density apolipoprotein A1 (Apo-A1). The present study was designed to evaluate cardioprotective potential of pitavastatin at 1 mg/kg/day and 3 mg/kg/day dose for 14 days in low dose isoproterenol (ISO) (5 mg/kg/day for 7 consecutive days) induced myocardial damage. ISO administration induced significant reduction in endogenous antioxidant enzymes like reduced glutathione (GSH), superoxide dismutase (SOD), catalase (CAT) and raised thiobarbituric acid reactive substances (TBARS) indicating activated lipid peroxidation...
September 7, 2018: Clinical and Experimental Hypertension: CHE
Ali M Shendi, Nathan Davies, Andrew Davenport
Previous reports linked systemic endotoxemia in dialysis patients to increased markers of inflammation, cardiovascular disease, and mortality. Many peritoneal dialysis (PD) patients use acidic, hypertonic dialysates, which could potentially increase gut permeability, resulting in systemic endotoxemia. However, the results from studies measuring endotoxin in PD patients are discordant. We therefore measured systemic endotoxin in 55 PD outpatients attending for routine assessment of peritoneal membrane function; mean age 58...
September 2018: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
Lucio Cagini, Marco Andolfi, Cecilia Becattini, Maria Giovanna Ranalli, Francesco Bartolucci, Alessandra Mancuso, Jacopo Vannucci, Giancarlo Agnelli, Francesco Puma
Background: Extra vascular lung water (EVLW) following pulmonary resection increases due to fluid infusion and rises in capillary surface and permeability of the alveolar capillary membranes. EVLW increase clinically correlates to pulmonary oedema and it may generate impairments of gas exchanges and acute lung injury. An early and reliable assessment of postoperative EVLW, especially following major pulmonary resection, is useful in terms of reducing the risk of postoperative complications...
July 2018: Journal of Thoracic Disease
Weimin Wei, Yan Chen, Da Lei, Yanan Zhang, Xiuhong Weng, Yuliang Zhou, Li Zhang
Plasma brain natriuretic peptide (BNP), a diagnostic marker of cardiovascular diseases, has been previously linked to cerebrovascular diseases. Our goal was to determine whether plasma BNP level is helpful for identifying high-risk individuals who are likely to present with the 3 main subtypes of cerebral small vessel diseases (CSVDs), namely, white matter lesions, lacunar infarcts, and cerebral microbleeds, on magnetic resonance imaging (MRI) in patients with hypertension.Three hundred forty-six consecutive hypertensive patients presenting at our cardiology or neurology clinic were investigated...
August 2018: Medicine (Baltimore)
Xiaozu Liao, Zhou Cheng, Liqiang Wang, Binfei Li
BACKGROUND: Acute kidney injury (AKI) during extracorporeal membrane oxygenation (ECMO) affects the prognosis of patients. In the present study, we explored the risk factors for AKI through a retrospective analysis of relevant data of patients undergoing ECMO with AKI. MATERIALS AND METHODS: Retrospective analysis was performed on patients with AKI who were receiving ECMO. Patient data, including preoperative basic conditions, related clinical conditions during ECMO, and complications, were collected...
October 2018: Clinical Nephrology
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