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brain natriuretic factor

Azra Durak-Nalbantic, Alen Dzubur, Naser Nabil, Aida Hamzic-Mehmedbasic, Faris Zvizdic, Enisa Hodzic, Nerma Resic
Introduction: Heart failure (HF) has very high rate of repeat hospitalizations due to HF decompensation (HHFD), sometimes very shortly after discharge for acute HF. Aim: The aim of this paper is to investigate rate of HHFD and to identify their possible predictors. Patients and Methods: Total amount of 222 patients hospitalized at Clinic for heart and vessel disease and rheumatism in acute HF were followed for next 18 months for occurrence of HHFD...
October 2018: Medical Archives
Lesley-Anne Bissell, Bara Erhayiem, Graham Fent, Elizabeth M A Hensor, Agata Burska, Helena Donica, Sven Plein, Maya H Buch, John P Greenwood, Jacqueline Andrews
BACKGROUND: Common carotid artery intima-media thickness (CIMT), as measured by ultrasound, has utility in stratification of the accelerated cardiovascular risk seen in rheumatoid arthritis (RA); however, the technique has limitations. Carotid magnetic resonance imaging (MRI) is emerging as a useful research tool in the general population, but has yet to be applied in RA populations. Our objectives were to describe the utility of carotid artery MRI (carotid-MRI) in patients with RA in comparison to healthy controls and to describe the association with RA disease phenotype...
December 3, 2018: Arthritis Research & Therapy
Xue Yu, Zhiwei Huang, Yi Zhang, Zhihong Liu, Qin Luo, Zhihui Zhao, Qing Zhao, Liu Gao, Qi Jin, Lu Yan
Background: Due to its effects, like an exaggerated negative intrathoracic pressure, sympathetic activation, systemic inflammation, oxidative stress, and endothelial dysfunction, obstructive sleep apnea (OSA) has been involved as a cause in multiple cardiovascular diseases. These diseases include coronary artery disease, hypertension, heart failure, and pulmonary hypertension (PH). Furthermore, OSA often coexists with chronic thromboembolic pulmonary hypertension (CTEPH) in clinical practice...
October 2018: Journal of Thoracic Disease
Zheng-Jie Meng, Chao Wang, Ling-Tong Meng, Bei-Hua Bao, Jin-Hui Wu, Yi-Qiao Hu
Cardiac dysfunction, a common consequence of sepsis, is the major contribution to morbidity and mortality in patients. Sodium tanshinone IIA sulfonate (STS) is a water-soluble derivative of Tanshinone IIA (TA), a main active component of Salvia miltiorrhiza Bunge, which has been widely used in China for the treatment of cardiovascular and cerebral system diseases. In the present study, the effect of STS on sepsis-induced cardiac dysfunction was investigated and its effect on survival rate of rats with sepsis was also evaluated...
November 2018: Chinese Journal of Natural Medicines
Tobias Feldreich, Christoph Nowak, Tove Fall, Axel C Carlsson, Juan-Jesus Carrero, Jonas Ripsweden, Abdul Rashid Qureshi, Olof Heimbürger, Peter Barany, Peter Stenvinkel, Nicolas Vuilleumier, Philip A Kalra, Darren Green, Johan Ärnlöv
INTRODUCTION: Proteomic profiling of end-stage renal disease (ESRD) patients could lead to improved risk prediction and novel insights into cardiovascular disease mechanisms. Plasma levels of 92 cardiovascular disease-associated proteins were assessed by proximity extension assay (Proseek Multiplex CVD-1, Olink Bioscience, Uppsala, Sweden) in a discovery cohort of dialysis patients, the Mapping of Inflammatory Markers in Chronic Kidney disease cohort [MIMICK; n = 183, 55% women, mean age 63 years, 46 cardiovascular deaths during follow-up (mean 43 months)]...
November 29, 2018: Journal of Nephrology
Xiantao Qin, Fangyuan Chang, Zhenfeng Wang, Wenying Jiang
OBJECTIVE: This study aimed to evaluate predictive value of 14 pro-angiogenic miRNAs for cardiotoxicity induced by epirubicin/cyclophosphamide follow by docetaxel (EC-D) in breast cancer (BC) patients. METHODS: Three hundred and sixty-three BC patients receiving EC-D neoadjuvant chemotherapy were consecutively enrolled in this prospective cohort study. Peripheral blood sample was obtained from each patient, and plasma was separated. The expressions of 14 pro-angiogenic miRNAs, cardiac troponin I (cTnI) and N-terminal pro brain natriuretic peptide (NT-proBNP) were evaluated...
November 5, 2018: Cancer Biomarkers: Section A of Disease Markers
Habib Bouzina, Göran Rådegran
In pulmonary arterial hypertension (PAH), severe vasoconstriction and remodelling of small pulmonary arteries result in high mortality. Receptor tyrosine kinases and their ligands, such as transforming growth factor (TGF)-α, modulate proliferation in PAH. Although the receptor tyrosine kinase c-Kit has been shown to be overexpressed in PAH, the expression and role of its ligand stem cell factor (SCF) remain unknown. However, low plasma SCF levels are known to be linked to higher cardiovascular mortality risk...
October 2018: ERJ Open Research
Justin Lee, Ryan McMillan, Leonidas Skiadopoulos, Vinod Bansal, José Biller, Debra Hoppensteadt, Jawed Fareed
The prevalence of neurocognitive deficits remains high in patients with stage 5 chronic kidney disease (CKD5D). Major contributors to such deficits include stroke, cervical carotid artery disease (CCAD), and intracranial atherosclerotic disease (ICAD). The risk of developing these dysfunctional vascular processes is facilitated by the chronic inflammation associated with renal failure. Plasma levels of 10 circulating biomarkers in patients with CKD5D (n = 78-90) were quantified using the sandwich enzyme linked immune sorbent assay method...
November 14, 2018: Clinical and Applied Thrombosis/hemostasis
B Zhang, S S Li, J L Men, Z H Zhang
Objective: To observe the effect of long term crotonaldehyde exposure on heart damage in male rats, and to explore the possible mechanism of toxic action. Methods: 24 specific pathogen free healthy male wistar rats were randomly divided into 4 groups with 6 rats in each group. Rats were treated with with 8.5, 4.5, 2.5 and 0.0 mg/kg body weight crotonaldehyde by gavage, once a day for consecutive 150 days. After the last treatment, they were anesthetized and collected blood samples by cardiac puncture. The heart was rapidly separated after cervical dislocation...
September 20, 2018: Chinese Journal of Industrial Hygiene and Occupational Diseases
Elena Dozio, Federico Ambrogi, Massimo de Cal, Elena Vianello, Claudio Ronco, Massimiliano M Corsi Romanelli
End-stage renal disease patients on dialysis (CKD-G5D) have a high mortality rate due to cardiovascular diseases (CVD). In these patients, inflammation, oxidative stress, and uremia increase the production of glycation products (AGEs) which in turn accelerate CVD onset and progression. Recently, attention has been given to the soluble receptor for AGEs (sRAGE) as a marker of inflammation, oxidative stress, atherosclerosis, and heart failure in CKD-G5D. However, its association with patient outcomes is still under debate...
2018: Mediators of Inflammation
Tomoaki Shiba, Mao Takahashi, Tadashi Matsumoto, Yuichi Hori
PURPOSE: To determine: (1) whether variables of a pulse wave form analysis of ocular microcirculation shown by laser speckle flowgraphy (LSFG) correlate with left ventricular (LV) systolic dysfunction and (2) whether these variables correlate with LV diastolic dysfunction in subjects without LV systolic dysfunction as assessed by echocardiography. METHODS: We studied 200 consecutive subjects. LV systolic dysfunction has been determined to be present when the LV ejection fraction was < 50%...
November 8, 2018: Journal of Vascular Research
Chih-Chao Yang, Yen-Ta Chen, Christopher Glenn Wallace, Kuan-Hung Chen, Ben-Chung Cheng, Pei-Hsun Sung, Yi-Chen Li, Sheung-Fat Ko, Hsueh-Wen Chang, Hon-Kan Yip
This study tested the hypothesis that early administration of empagliflozin (Empa), an inhibitor of glucose recycling in renal tubules, could preserve heart function in cardiorenal syndrome (CRS) in rat. Chronic kidney disease (CKD) was caused by 5/6 subtotal nephrectomy and dilated cardiomyopathy (DCM) by doxorubicin (DOX) treatment. In vitro results showed that protein expressions of cleaved-caspase3 and autophagy activity at 24 h/48 h in NRK-52P cells were significantly upregulated by para-Creso treatment; these were significantly downregulated by Empa treatment...
November 4, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Mladjan Golubović, Velimir Peric, Dragana Stanojevic, Milan Lazarevic, Nenad Jovanovic, Nenad Ilic, Miodrag Djordjevic, Tomislav Kostić, Dragan J Milic
OBJECTIVE: The aim of our study was to find the best model with sufficient power to improve the risk stratification in major vascular surgery patients during the first 30 days after this procedure. The discriminatory power of 4 biomarkers [troponin I (TnI), N terminal brain natriuretic peptide (NT-ProBNP), Creatine kinase-MBenotype (CK-MB), high sensitivity C-reactive protein (hs-CRP)] was tested and 2 risk assessment models, with 13 different combinations of them. SUBJECT AND METHODS: The study included 122 patients (men - 77%, women - 23%) with an average age of 67...
November 4, 2018: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
Sukhinder K Cheema, Paramjit S Tappia, Naranjan S Dhalla
Regulation of cardiac fatty acid metabolism is central to the development of cardiac hypertrophy and heart failure. We investigated the effects of some specific fatty acids on the expression of genes involved in immediate early as well as inflammatory and hypertrophic responses in adult rat cardiomyocytes. Cardiac remodeling begins with upregulation of immediate early genes c-fos and c-jun, followed by upregulation of inflammatory genes such as NF-kB and NFAT. At later stages, genes involved in the hypertrophic responses such as atrial natriuretic peptide (ANP) and brain natriuretic factor (BNF) are upregulated...
November 2, 2018: Canadian Journal of Physiology and Pharmacology
Aleksander J Owczarek, Piotr Choręza, Habibullah Arabzada, Jerzy Chudek, Romuald Wojnicz
OBJECTIVE: The aim of this study was to assess the role of potential factors explaining variability of serum uric acid (SUA) levels in patients with chronic heart failure with reduced ejection fraction (HFrEF) not receiving xanthine oxidase inhibitors and acetylsalicylic acid, with multivariate adaptive regression splines and fuzzy c -regression models. MATERIAL AND METHODS: Between 1998 and 2010, we prospectively enrolled 294 patients (44 females, 250 males; mean age 43...
September 2018: Annals of Clinical and Laboratory Science
Bei-Lei Liu, Mian Cheng, Shan Hu, Shun Wang, Le Wang, Xin Tu, Cong-Xin Huang, Hong Jiang, Gang Wu
BACKGROUND AND PURPOSE: Our previous studies have shown that Src homology 2 (SH2) B adaptor protein 1 (SH2B1) plays an important role in cardiac hypertrophy, but the specific mechanism remains to be studied. Through bioinformatics and related research, it is found that miR-14 2-3 p is closely related to SH2B1. Exploring the relationship between miR-14 2-3 p and gene SH2B1 expression is beneficial for the treatment of cardiac hypertrophy. SH2B1 is a key factor regulating energy metabolism, mitochondria are the main organelles of energy metabolism and cardiac hypertrophy are closely related to mitochondrial dysfunction...
December 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Maarten J G Leening, Nancy R Cook, Oscar H Franco, JoAnn E Manson, Kamakshi Lakshminarayan, Michael J LaMonte, Enrique C Leira, Jennifer G Robinson, Paul M Ridker, Nina P Paynter
Background Cardiovascular risk factors have differential effects on various manifestations of cardiovascular disease, but to date direct formal comparisons are scarce, have been conducted primarily in men, and include only traditional risk factors. Methods and Results Using data from the multi-ethnic Women's Health Initiative Observational Study, we used a case-cohort design to compare 1731 women with incident cardiovascular disease during follow-up to a cohort of 1914 women. The direction of effect of all 24 risk factors (including various apolipoproteins, hemoglobin A1c , high-sensitivity C-reactive protein, N-terminal pro-brain natriuretic peptide, and tissue plasminogen activator antigen) was concordant for coronary heart disease (CHD, defined as myocardial infarction and CHD death) and ischemic stroke; however, associations were generally stronger with CHD...
October 2, 2018: Journal of the American Heart Association
De-Qiang Zhang, Hong-Wei Li, Hai-Ping Chen, Qing Ma, Hui Chen, Yun-Li Xing, Xue-Qiao Zhao
Background Cardiorenal syndrome type 1 ( CRS 1) as a complication of acute myocardial infarction can lead to adverse outcomes, and a method for early detection is needed. This study investigated the individual and integrated effectiveness of amino-terminal pro-brain natriuretic peptide (Pro-BNP), estimated glomerular filtration rate (eGFR), and high-sensitivity C-reactive protein (CRP) as predictive factors for CRS 1 in patients with acute myocardial infarction. Methods and Results In a retrospective analysis of 2094 patients with acute myocardial infarction, risk factors for CRS 1 were analyzed by logistic regression...
October 2, 2018: Journal of the American Heart Association
Simon Correa, David A Morrow, Eugene Braunwald, Richard Y Davies, Erica L Goodrich, Sabina A Murphy, Christopher P Cannon, Michelle L O'Donoghue
Background Cystatin C (Cys-C) is a marker of renal function that has shown prognostic value for cardiovascular risk stratification across different patient populations. The incremental value of Cys-C beyond established cardiac and renal biomarkers remains incompletely explored. Methods and Results SOLID - TIMI 52 (Stabilization of Plaques Using Darapladib-Thrombolysis in Myocardial Infarction 52; , NCT01000727) randomized patients ≤30 days post-acute coronary syndrome were treated with darapladib or placebo...
October 16, 2018: Journal of the American Heart Association
Sylvain Recoquillon, Jean-Louis Pépin, Bruno Vielle, Ramaroson Andriantsitohaina, Vanessa Bironneau, Frédérique Chouet-Girard, Bernard Fleury, François Goupil, Sandrine Launois, M Carmen Martinez, Nicole Meslier, Xuan-Lan Nguyen, Audrey Paris, Pascaline Priou, Renaud Tamisier, Wojciech Trzepizur, Frédéric Gagnadoux
Systemic inflammation and metabolic disorders are among the mechanisms linking obstructive sleep apnoea (OSA) and cardiovascular disease (CVD). In 109 patients with severe OSA and no overt CVD, biomarkers of inflammation (C reactive protein, interleukin-6, tumour necrosis factor-α and its receptors, adiponectin, leptin and P-selectin), glucose and lipid metabolism, and N-terminal pro-brain natriuretic peptide, were measured before and after 2 months of treatment with a mandibular advancement device (MAD) (n=55) or a sham device (n=54)...
October 26, 2018: Thorax
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