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brain natriuretic factor

Maciej Liczek, Iga Panek, Piotr Damiański, Olga Jęczeń, Jędrzej Jaźwiec, Piotr Kuna, Michał Panek
The aim of the study was to find out scientific evidence on the possible use of the combined angiotensin II receptor antagonist and neprilysin inhibitors (ARNI) in patients with right heart failure (RHF) in the course of chronic obstructive pulmonary disease (COPD). It has been proven that a lack of neprilysin or its reduced expression in hypoxia leads to exacerbation of pulmonary arterial remodelling (PAR) or pulmonary hypertension (PH) in the mechanism related to the platelet-derived growth factor (PDGF) resulting in the proliferation and migration of pulmonary artery smooth muscle cells and endothelial-to-mesenchymal transition...
August 15, 2018: Advances in Respiratory Medicine
Sadia Shah, Md Sayeed Akhtar, Md Quamrul Hassan, Mohd Akhtar, Yam Nath Paudel, Abul Kalam Najmi
AIM: Epidermal growth factor receptor (EGFR) related reactive oxygen species (ROS) generation results in myocardial damage. We aimed to investigate the role of gefitinib (EGFR-tyrosine kinase inhibitor) in diabetic cardiomyopathy (DbCM). METHOD: DbCM was induced by injecting streptozotocin (55 mg/kg for 5 consecutive days) to C57/BL6 mice intraperitoneally. Diabetic C57/BL6 mice (fasting blood glucose level ≥ 250 mg/dl) were allocated into four study groups and treated with two doses of gefitinib (30 mg/kg and 350 mg/kg per day) as well as ramipril (3 mg/kg/day) for four weeks...
August 11, 2018: Life Sciences
Dorota Sikorska, Anna Olewicz-Gawlik, Ewa Baum, Krzysztof Pawlaczyk, Andrzej Oko
BACKGROUND: High mortality in peritoneal dialysis (PD) patients is associated with the presence of nontraditional cardiovascular risk factors, such as malnutrition. However, hypoalbuminemia in patients undergoing PD may have gender-dependent consequences. OBJECTIVES: The aim of the study was to evaluate the relationship between hypoalbuminemia, overhydration (OH), inflammation, and cardiovascular risk, depending on gender. MATERIAL AND METHODS: The group studied consisted of 54 PD patients: 26 male (mean age: 59 ±19 years) and 28 female (mean age: 52 ±15 years) patients...
August 14, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
Masahide Harada, Masayuki Koshikawa, Yuji Motoike, Tomohide Ichikawa, Kunihiko Sugimoto, Eiichi Watanabe, Yukio Ozaki
BACKGROUND: In atrial fibrillation (AF) patients, the effect of direct oral anticoagulant (DOACs) therapy on the incidence of left atrial appendage thrombus (LAT) remains poorly investigated. This study examined the prevalence and risk factors of LAT in AF patients on DOACs undergoing catheter ablation, and sought an anticoagulation strategy for LAT.Methods and Results:In 407 AF patients on DOACs, transesophageal echocardiography (TEE) was performed 1 day before ablation. If patients had LAT, initial DOACs were switched to dabigatran (300 mg) or warfarin based on their renal function; TEE was repeated after treatment for ≥4 weeks...
August 11, 2018: Circulation Journal: Official Journal of the Japanese Circulation Society
Yong-Zeng Chen, Fan Wang, Hai-Jun Wang, Hong-Bin Liu
Objective: To investigate the role of sphingosine-1-phosphate (S1P) and its receptors in cardiomyocyte autophagy, cardiomyocyte hypertrophy and cardiac function. Methods: Cardiomyocytes were isolated from neonatal Vista rats. Autophagy and hypertrophy of cardiomyocytes were induced via starvation culture and phenylephrine (PE), respectively, and S1P was used to treat the cardiomyocytes. The effect of S1P on cardiomyocyte autophagy was evaluated by the number of autophagosomes, the expression of autophagy-related proteins and autophagic marker genes in cardiomyocytes...
May 2018: Journal of Geriatric Cardiology: JGC
Alexander Riad, Stefan Gross, Jeannine Witte, Rico Feldtmann, Katharina B Wagner, Yvonne Reinke, Kerstin Weitmann, Klaus Empen, Daniel Beug, Dirk Westermann, Diana Lindner, Karin Klingel, Marcus Dörr, Wolfgang Hoffmann, Stephan B Felix
BACKGROUND: Myeloid differentiation factor-2 (MD-2) has been shown to be an important modulator of the innate immune system, but its role in cardiac diseases is unknown. We investigated whether MD-2 plays a role as risk predictor and contributor in dilated cardiomyopathy (DCM). METHODS AND RESULTS: We included 174 patients with reduced left ventricular (LV) ejection fraction (LVEF <45%) due to DCM. Coronary artery disease and severe valvular diseases were excluded in all patients by angiography or echocardiography...
June 13, 2018: International Journal of Cardiology
Lea Winau, Rocio Hinojar Baydes, Axel Braner, Ulrich Drott, Harald Burkhardt, Shirish Sangle, David P D'Cruz, Gerry Carr-White, Mike Marber, Katrin Schnoes, Christophe Arendt, Karin Klingel, Thomas J Vogl, Andreas M Zeiher, Eike Nagel, Valentina O Puntmann
BACKGROUND: Cardiovascular (CV) involvement in patients with systemic lupus erythematosus (SLE) is presumably subclinical for the major part of its evolution. We evaluated the associations between high-sensitive troponin T (hs-TropT), a sensitive marker of myocardial injury, and CV involvement using cardiac magnetic resonance (CMR). METHODS AND RESULTS: This is a two-centre (London and Frankfurt) CMR imaging study at 3.0 Tesla of consecutive 92 patients with SLE free of cardiac symptoms, undergoing screening for cardiac involvement...
August 4, 2018: Annals of the Rheumatic Diseases
Xiuhong Zhou, Xinping Du, Kuan Wang, Guoxing Zuo, Sheng Hu, Jinhong Xue, Dandan Yuan, Jiaojiao Du
OBJECTIVE: To investigate the clinical application and effect evaluation of failure mode and effect analysis (FMEA) in the optimization of vascular recanalization in patients with ST-segment elevation myocardial infarction (STEMI). METHODS: A total of 389 STEMI patients admitted to the emergency department of the Fifth Central Hospital in Tianjin from January 2014 to January 2015 were served as the control group, and 398 STEMI patients admitted to the chest pain center of the Fifth Central Hospital in Tianjin from January 2016 to October 2017 were served as the experimental group...
July 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
Tetsuya Takahashi, Tetsuro Shishido, Ken Watanabe, Takayuki Sugai, Taku Toshima, Daisuke Kinoshita, Miyuki Yokoyama, Harutoshi Tamura, Satoshi Nishiyama, Hiroki Takahashi, Takanori Arimoto, Takuya Miyamoto, Tetsu Watanabe, Yoko Shibata, Tsuneo Konta, Yoshiyuki Ueno, Takeo Kato, Takamasa Kayama, Isao Kubota, Masafumi Watanabe
Pulse pressure (PP) is a risk factor for cardiovascular diseases and is associated with increased afterload and myocardial oxygen demand. Brain natriuretic peptide (BNP) and heart-type fatty acid-binding protein (H-FABP) are known as biomarkers indicating ventricular wall stress and silent myocardial damage. However, the association between PP and ventricular wall stress and silent myocardial damage in the general population is unclear. The authors enrolled 3504 patients who participated in a community-based annual health check...
July 23, 2018: Journal of Clinical Hypertension
L Zhu, T Qian, X-W Zhang, W Huang, W-H Li
OBJECTIVE: We explored the possibility of using the variations in the pro-brain natriuretic peptide (NT-proBNP) of serum amino-terminal and norepinephrine (NE) levels as prognostic as well as diagnostic factors in children suffering from severe hand-foot-and-mouth disease (HFMD). PATIENTS AND METHODS: From February 2014 to February 2015, 102 HFMD patients were enrolled in this study. They were divided into the common group (n=55) and the severe group (n=47). During the same period, 30 healthy children were enrolled in the control group...
July 2018: European Review for Medical and Pharmacological Sciences
Yusuke Oba, Satoshi Hoshide, Tomoyuki Kabutoya, Kazuomi Kario
BACKGROUND: Heart rate (HR) assessed by electrocardiogram (ECG-HR) and pulse rate (PR) measured in a physician's office (office-PR) are taken with subjects in different body positions-i.e., supine vs. sitting. Although analysis of HR differences according to body position could provide new practical insights, there have been few studies on the subject. We herein investigated whether the difference between office-PR and ECG-HR (delta HR) was associated with brain natriuretic peptide (BNP) levels and left ventricular mass (LVM)...
July 17, 2018: American Journal of Hypertension
Maren Leifheit-Nestler, Beatrice Richter, Melis Basaran, Julia Nespor, Isabel Vogt, Ioana Alesutan, Jakob Voelkl, Florian Lang, Joerg Heineke, Stefanie Krick, Dieter Haffner
Clinical and experimental studies indicate a possible link between high serum levels of fibroblast growth factor 23 (FGF23), phosphate, and parathyroid hormone (PTH), deficiency of active vitamin D (1,25D) and klotho with the development of pathological cardiac remodeling, i.e., left ventricular hypertrophy and myocardial fibrosis, but a causal link has not been established so far. Here, we investigated the cardiac phenotype in klotho hypomorphic ( kl/kl ) mice and Hyp mice, two mouse models of elevated FGF23 levels and klotho deficiency, but differing in parameters of mineral metabolism, by using histology, quantitative real-time PCR, immunoblot analysis, and serum and urine biochemistry...
2018: Frontiers in Endocrinology
Ali Kemal Kalkan, Huseyin Altug Cakmak, Mehmet Erturk, Kübra Erol Kalkan, Fatih Uzun, Omer Tasbulak, Vesile Ornek Diker, Suleyman Aydin, Ahmet Celik
BACKGROUND: Cardiac cachexia is an important predictive factor of the reduction in survival of patients with heart failure with reduced ejection fraction. OBJECTIVES: The aims of the present study were to evaluate adropin and irisin levels in cachectic and non-cachectic subjects and the relationships between the levels of these proteins and clinical and laboratory parameters in patients with HFrEF. METHODS: The clinical records of patients who were admitted to the cardiology outpatient clinic for heart failure with reduced ejection fraction were screened...
July 2, 2018: Arquivos Brasileiros de Cardiologia
E Gómez-Guzmán, M D Cañete, R Valle-Martos, R Cañete, M Valle, L Jiménez-Reina, J Caballero-Villarraso
Background: Our study was designed to assess the effects of GHD on nutritional and metabolic parameters, brain natriuretic peptide (BNP) levels, and left ventricular mass (LVM) in prepubertal children and after short-term GH replacement therapy. Materials and Methods: This prospective study enrolled 81 children. We compared 40 GHD children (16 males and 24 females) to 41 healthy children (control group) (18 males and 23 females). All subjects were at Tanner Stage I (aged 7-11 years). At the baseline, a blood sample was drawn and echocardiographic images were obtained...
2018: Frontiers in Pediatrics
Balazs Odler, Vasile Foris, Anna Gungl, Veronika Müller, Paul M Hassoun, Grazyna Kwapiszewska, Horst Olschewski, Gabor Kovacs
Pulmonary arterial hypertension (PAH) is a severe complication of systemic sclerosis (SSc) associated with high morbidity and mortality. There are several biomarkers of SSc-PAH, reflecting endothelial physiology, inflammation, immune activation, extracellular matrix, metabolic changes, or cardiac involvement. Biomarkers associated with diagnosis, disease severity and progression have been identified, however, very few have been tested in a prospective setting. Some antinuclear antibodies such as nucleosome antibodies (NUC), anti-centromere antibodies (CENP-A/B) and anti-U3-ribonucleoprotein (anti-U3-RNP) are associated with PAH while anti-U1-ribonucleoprotein (anti-U1-RNP) is associated with a reduced PAH risk...
2018: Frontiers in Physiology
Sheila K Patel, Elena Velkoska, Daniel Gayed, Jay Ramchand, Jessica Lesmana, Louise M Burrell
BACKGROUND: Left ventricular hypertrophy (LVH) increases the risk of death in chronic kidney disease (CKD). The transcription factor Kruppel-like factor 15 (KLF15) is expressed in the heart and regulates cardiac remodelling through inhibition of hypertrophy and fibrosis. It is unknown if KLF15 expression is changed in CKD induced LVH, or whether expression is modulated by blood pressure reduction using angiotensin converting enzyme (ACE) inhibition. METHODS: CKD was induced in Sprague-Dawley rats by subtotal nephrectomy (STNx), and rats received vehicle (n = 10) or ACE inhibition (ramipril, 1 mg/kg/day, n = 10) for 4 weeks...
July 3, 2018: BMC Nephrology
Małgorzata Mitkiewicz, Bernadeta Bac, Marianna Kuropatwa, Ewa Kurowska, Janusz Matuszyk, Jakub Siednienko
Cyclic guanosine monophosphate (cGMP) is synthesized by two types of enzymes: particulate (membrane-bound) guanylyl cyclases (pGCs) and soluble (cytosolic) guanylyl cyclases (sGCs). sGCs are primarily activated by binding of nitric oxide to their prosthetic heme group while pGCs are activated by binding of peptide ligands to their extracellular domains. One of them, pGC type A (GC-A) is activated by atrial and brain natriuretic peptides (ANP and BNP, respectively). Human monocytes isolated from peripheral blood mononuclear cells have been found to display sGC expression without concomitant expression of GC-A...
June 30, 2018: Acta Biochimica Polonica
Dandan Song, Xuelei Liu, Yugang Diao, Yingjie Sun, Guangjie Gao, Tiezheng Zhang, Keyan Chen, Ling Pei
Myocardial ischemia, hypoxia and reperfusion injury are induced by aortic occlusion, cardiac arrest and resuscitation during cardiopulmonary bypass (CPB), which can severely affect cardiac function. The aim of the present study was to investigate the effects of hydrogen‑rich solution (HRS) and aquaporin (AQP) on cardiopulmonary bypass (CPB)‑induced myocardial injury, and determine the mechanism of the phosphatidylinositol 3‑kinase (PI3K)/protein kinase B (Akt) signaling pathway. Sprague Dawley rats were divided into a sham operation group, a CPB surgery group and a HRS group...
August 2018: Molecular Medicine Reports
Marja G J Veugen, Ronald M A Henry, Hans-Peter Brunner-La Rocca, Pieter C Dagnelie, Miranda T Schram, Marnix J M van Agtmaal, Carla J H van der Kallen, Simone J S Sep, Martin P J van Boxtel, Otto Bekers, Steven J R Meex, Jacobus F A Jansen, Abraham A Kroon, Coen D A Stehouwer
OBJECTIVE: NT-proBNP (N-terminal pro-B-type natriuretic peptide) and cardiac troponin T (cTNT) are associated with cognitive performance. Whether this extends to individuals <60 years of age is unclear. We investigated whether age modified the associations between NT-proBNP and cTNT and cognitive performance and structural brain changes. APPROACH AND RESULTS: In 3011 individuals (60±8 years; 49% women), NT-proBNP and cTNT, memory, information processing speed and executive functioning, grey matter (GM) and white matter, and white matter hyperintensity (WMH) volumes were determined...
June 28, 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
Serdar Kula, Fatma Canbeyli, Vildan Atasayan, Fatma Sedef Tunaoğlu, Ayşe Deniz Oğuz
OBJECTIVE: The aim of this study was to evaluate children with pulmonary arterial hypertension (PAH) regarding epidemiological characteristics, clinical status with respect to the WHO functional class (WHO-FC), prognostic factors, and efficacy of medical treatment. METHODS: A retrospective evaluation of 41 patients with PAH was made in the Pediatric Cardiology Unit, Gazi University Medical Faculty, between February 2006 and October 2015. RESULTS: Of the 41 patients included in this study, 51...
July 2018: Anatolian Journal of Cardiology
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