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adult-onset diabetes

Anna R Kahkoska, Scott Isom, Jasmin Divers, Elizabeth J Mayer-Davis, Lawrence Dolan, Amy S Shah, Maryam Afkarian, David J Pettitt, Jean M Lawrence, Santica Marcovina, Sharon H Saydah, Dana Dabelea, David M Maahs, Amy K Mottl
AIMS: To determine among adolescents and young adults with youth-onset type 1 diabetes and type 2 diabetes the rates and risk factors for albuminuria regression and progression. METHODS: Data from SEARCH, a longitudinal observational study of youth-onset type 1 diabetes (N = 1316) and type 2 diabetes (N = 143) were analyzed. Urine albumin:creatinine ratio (UACR) was measured from random urine specimens at baseline and follow-up visits (mean 7 years later)...
October 4, 2018: Journal of Diabetes and its Complications
Adelina Martín Salvador, Rafael Fernández Castillo, Inmaculada García García, María José Aguilar Cordero, Juan Bravo Soto
INTRODUCTION: the appearance of metabolic syndrome (MS) among renal recipients is one of the greatest post-transplant complications and is associated with an increased risk of graft failure and high rates of obesity and new onset diabetes. OBJECTIVE: the objective of this work is to identify the relationship between the glomerular filtration rate measured by two different methods and the components of the metabolic syndrome and their combinations in kidney transplant patients according to gender...
October 5, 2018: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
Lindsay Fernández-Rhodes, Annie Green Howard, Mariaelisa Graff, Carmen R Isasi, Heather M Highland, Kristin L Young, Esteban Parra, Jennifer E Below, Qibin Qi, Robert C Kaplan, Anne E Justice, George Papanicolaou, Cathy C Laurie, Struan F A Grant, Christopher Haiman, Ruth J F Loos, Kari E North
Background: Genome-wide association studies have implicated the transcription factor 7-like 2 ( TCF7L2 ) gene in type 2 diabetes risk, and more recently, in decreased body mass index. Given the contrary direction of genetic effects on these two traits, it has been suggested that the observed association with body mass index may reflect either selection bias or a complex underlying biology at TCF7L2 . Methods: Using 9031 Hispanic/Latino adults (21-76 years) with complete weight history and genetic data from the community-based Hispanic Community Health Study/Study of Latinos (HCHS/SOL, Baseline 2008-2011), we estimated the multivariable association between the additive number of type 2 diabetes increasing-alleles at TCF7L2 (rs7903146-T) and body mass index...
2018: BMC Obesity
Michael P Bancks, Mercedes R Carnethon, David R Jacobs, Lenore J Launer, Jared P Reis, Pamela J Schreiner, Ravi V Shah, Stephen Sidney, Kristine Yaffe, Yuichiro Yano, Norrina B Allen
OBJECTIVE: To determine whether intraindividual variability in fasting glucose (FG) below the threshold of diabetes is associated with cognitive function in middle adulthood beyond increasing FG. RESEARCH DESIGN AND METHODS: We studied 3,307 CARDIA (Coronary Artery Risk Development Study in Young Adults) participants (age range 18-30 years; 1985-1986) at baseline and calculated two measures of long-term glucose variability: the coefficient of variation about the mean FG (CV-FG) and the absolute difference between successive FG measurements [average real variability (ARV-FG)] before the onset of diabetes over 25 and 30 years of follow-up...
October 10, 2018: Diabetes Care
Kelly M Kenzik, Amitkumar Mehta, Joshua S Richman, Meredith Kilgore, Smita Bhatia
BACKGROUND: To the authors' knowledge, there is limited information regarding the long-term risk of congestive heart failure (CHF) among patients with follicular lymphoma, a prevalent non-Hodgkin lymphoma diagnosis among those aged >65 years, especially within the context of therapeutic exposures and preexisting comorbidities. METHODS: Using Surveillance, Epidemiology, and End Results-Medicare data from 1999 through 2013, the authors identified 6109 patients with follicular lymphoma who were diagnosed at age ≥66 years between January 1, 2000 and December 31, 2011, and a frequency-matched Medicare noncancer sample...
October 10, 2018: Cancer
Adriana Rusu, Dana Ciobanu, Cornelia Bala, Anca Cerghizan, Gabriela Roman
BACKGROUND: Social jetlag (SJL) is a small recurrent circadian rhythm disruption and the most frequent form of circadian rhythm misalignment. The main objective of this study was to investigate in real-life settings the effect of SJL on glycemic control, as assessed by glycated hemoglobin (HbA1c). METHODS: 115 consecutive patients with type 1 diabetes were analyzed cross-sectionally. Data on bedtime, sleep-onset latency, and wake-up time on weekdays and weekends during the previous month were collected from all participants and were used to calculate SJL, chronotype, and sleep duration...
October 10, 2018: Journal of Diabetes
Camille Vatier, Marie-Christine Vantyghem, Caroline Storey, Isabelle Jéru, Sophie Christin-Maitre, Bruno Fève, Olivier Lascols, Jacques Beltrand, Jean-Claude Carel, Corinne Vigouroux, Elise Bismuth
Lipodystrophic syndromes are rare diseases of genetic or acquired origin characterized by partial or generalized lack of body fat. Early detection and diagnosis are crucial to prevent and manage associated metabolic dysfunctions, i.e. insulin resistance, dyslipidemia, fatty liver and diabetes, and to provide appropriate genetic counselling. By means of several representative case studies, this article illustrates the diagnostic and management challenges of lipodystrophic syndromes. Berardinelli-Seip congenital lipodystrophy (BSCL) is typically diagnosed at birth, or soon thereafter, with generalized lipoatrophy and hepatomegaly secondary to hepatic steatosis...
October 8, 2018: Current Medical Research and Opinion
Dulaney A Wilson, Braxton B Wannamaker, Angela M Malek, Anbesaw W Selassie
INTRODUCTION: Cardiovascular comorbidities of epilepsy such as hypertension, hyperlipidemia, and diabetes are associated with myocardial infarction (MI). Little data on the development of subsequent cardiovascular disease (CVD) in persons with epilepsy (PWE) are available, with inconsistent findings regarding the association between epilepsy and subsequent MI. A higher risk of MI among adults (without prior MI) following epilepsy diagnosis compared with that among controls was hypothesized...
October 3, 2018: Epilepsy & Behavior: E&B
Miia Kivipelto, Francesca Mangialasche, Tiia Ngandu
Research into dementia prevention is of paramount importance if the dementia epidemic is to be halted. Observational studies have identified several potentially modifiable risk factors for dementia, including hypertension, dyslipidaemia and obesity at midlife, diabetes mellitus, smoking, physical inactivity, depression and low levels of education. Randomized clinical trials are needed that investigate whether interventions targeting these risk factors can reduce the risk of cognitive decline and dementia in elderly adults, but such trials are methodologically challenging...
October 5, 2018: Nature Reviews. Neurology
Kota Katanoda, Mitsuhiko Noda, Atsushi Goto, Hideki Mizunuma, Jung Su Lee, Kunihiko Hayashi
AIMS: To examine the association between adult-onset diabetes and life-course body weight changes. METHODS: In a cross-sectional study, 17,398 Japanese female nurses aged ≥30 completed a self-administered questionnaire in 2001-2007. Body weight indices were calculated for three life stages: birth weight (adjusted for gestational age), body mass index (BMI) at age 18, and current BMI. Odds ratios for being diagnosed with adult-onset diabetes were calculated according to the combined body weight categories of two life stages: at birth and age 18; and at age 18 and the survey (current)...
October 5, 2018: Journal of Diabetes Investigation
Deirdre Hahn, Elisabeth M Hodson, Denis Fouque
BACKGROUND: Chronic kidney disease (CKD) is defined as reduced function of the kidneys present for 3 months or longer with adverse implications for health and survival. For several decades low protein diets have been proposed for participants with CKD with the aim of slowing the progression to end-stage kidney disease (ESKD) and delaying the onset of renal replacement therapy. However the relative benefits and harms of dietary protein restriction for preventing progression of CKD have not been resolved...
October 4, 2018: Cochrane Database of Systematic Reviews
Stephen Linder, Dritana Marko, Ye Tian, Tami Wisniewski
Of the 382 million people worldwide with diabetes, and if current trends continue, nearly half a billion people worldwide will have diabetes by 2035. Two-thirds of current diabetics are living in urban centers and the urban concentration of individuals with diabetes is on the rise. The problem is that in the absence of widespread clinical testing, there is no reliable way to predict which segments of the population are the most vulnerable to the onset of diabetes. Knowing who the most vulnerable are, and where they live, can guide the efficient allocation of prevention resources...
October 2, 2018: International Journal of Environmental Research and Public Health
Frederick J Raal, G Kees Hovingh, Alberico L Catapano
Familial hypercholesterolemia (FH) is a genetic disorder resulting from mutations in genes encoding proteins involved in the metabolism of low density lipoproteins (LDL) and characterized by premature cardiovascular disease due to the exposure to high levels of LDL-cholesterol (LDL-C) from birth. Thus, the early identification of FH subjects, followed by appropriate treatment is essential to prevent or at least delay the onset of cardiovascular events. However, FH is largely underdiagnosed; in addition, FH patients are frequently not adequately treated, despite the availability of several pharmacological therapies to significantly reduce LDL-C levels...
October 2018: Atherosclerosis
Xiaoyu Chen, Junhui Guo, Peipei Han, Liyuan Fu, Liye Jia, Hairui Yu, Xing Yu, Lin Hou, Lu Wang, Wen Zhang, Kaijun Niu, Qi Guo
OBJECTIVE: The objective of this study was to examine the incidence of new onset depressive symptoms and associated factors over a 1-year period in an older Chinese suburban population. DESIGN: Prospective cohort study. SETTING AND PARTICIPANTS: The sample comprised 691 Chinese community-dwelling participants (304 men; mean age 67.5 ± 5.7 years) without depressive symptoms at baseline, recruited from Chadian of Tianjin, China. MEASURES: We had documented detailed information regarding sociodemographics, behavioral characteristics, and medical conditions...
September 26, 2018: Journal of the American Medical Directors Association
A Elenkov, Y Al-Jebari, A Giwercman
Register-based studies have indicated that men with impaired fertility are at higher risk for developing various adult-onset diseases than fertile men. The majority of men undergoing ICSI treatment are sub-fertile and since they are in contact with the health care system, these men are well suited as target for preventive measures. Our study included all men (N = 459 766) who had fathered children in Sweden between 2006 and 2016. Swedish registry data was used for obtaining information regarding conception method and defining three groups of fathers - ICSI -treated, IVF - treated and non IVF/ICSI...
September 28, 2018: Scientific Reports
Mohammed E Al-Sofiani, Lisa R Yanek, Nauder Faraday, Brian G Kral, Rasika Mathias, Lewis C Becker, Diane M Becker, Dhananjay Vaidya, Rita R Kalyani
Context: Previous studies have suggested less cardioprotective benefit of aspirin in adults with diabetes, raising concerns about "aspirin resistance" and potentially reduced effectiveness for prevention of cardiovascular disease(CVD). Objective: To examine differences in platelet response to aspirin by diabetes status. Design, Setting, Participants: We examined platelet response before and after aspirin (81 mg/day for 14 days) in 2,113 adults(175 with diabetes, 1,938 without diabetes), in the Genetic Study of Aspirin Responsiveness(GeneSTAR) cohort, who had family history of early-onset CVD...
September 27, 2018: Journal of Clinical Endocrinology and Metabolism
Pia Leete, Roberto Mallone, Sarah J Richardson, Jay M Sosenko, Maria J Redondo, Carmella Evans-Molina
PURPOSE OF REVIEW: To explore the impact of age on type 1 diabetes (T1D) pathogenesis. RECENT FINDINGS: Children progress more rapidly from autoantibody positivity to T1D and have lower C-peptide levels compared to adults. In histological analysis of post-mortem pancreata, younger age of diagnosis is associated with reduced numbers of insulin containing islets and a hyper-immune CD20hi infiltrate. Moreover compared to adults, children exhibit decreased immune regulatory function and increased engagement and trafficking of autoreactive CD8+ T cells, and age-related differences in β cell vulnerability may also contribute to the more aggressive immune phenotype observed in children...
September 26, 2018: Current Diabetes Reports
Diana L Cousminer, Emma Ahlqvist, Rajashree Mishra, Mette K Andersen, Alessandra Chesi, Mohammad I Hawa, Asa Davis, Kenyaita M Hodge, Jonathan P Bradfield, Kaixin Zhou, Vanessa C Guy, Mikael Åkerlund, Mette Wod, Lars G Fritsche, Henrik Vestergaard, James Snyder, Kurt Højlund, Allan Linneberg, Annemari Käräjämäki, Ivan Brandslund, Cecilia E Kim, Daniel Witte, Elin Pettersen Sørgjerd, David J Brillon, Oluf Pedersen, Henning Beck-Nielsen, Niels Grarup, Richard E Pratley, Michael R Rickels, Adrian Vella, Fernando Ovalle, Olle Melander, Ronald I Harris, Stephen Varvel, Valdemar E R Grill, Hakon Hakonarson, Philippe Froguel, John T Lonsdale, Didac Mauricio, Nanette C Schloot, Kamlesh Khunti, Carla J Greenbaum, Bjørn Olav Åsvold, Knud B Yderstræde, Ewan R Pearson, Stanley Schwartz, Benjamin F Voight, Torben Hansen, Tiinamaija Tuomi, Bernhard O Boehm, Leif Groop, R David Leslie, Struan F A Grant
OBJECTIVE: Latent autoimmune diabetes in adults (LADA) shares clinical features with both type 1 and type 2 diabetes; however, there is ongoing debate regarding the precise definition of LADA. Understanding its genetic basis is one potential strategy to gain insight into appropriate classification of this diabetes subtype. RESEARCH DESIGN AND METHODS: We performed the first genome-wide association study of LADA in case subjects of European ancestry versus population control subjects ( n = 2,634 vs...
September 25, 2018: Diabetes Care
Hannah A Blair
The adhesive capsaicin dermal patch (Qutenza® ) delivers a high concentration (8% w/w) of synthetic capsaicin, a highly selective agonist of transient receptor potential vanilloid-1 (TRPV-1), directly to the site of pain. The capsaicin 8% dermal patch is indicated in the EU for the treatment of peripheral neuropathic pain (PNP) in adults, either alone or in combination with other medicinal products for pain. In patients with painful diabetic peripheral neuropathy, a single 30-min application of the capsaicin 8% dermal patch provided 12 weeks of pain relief and improved sleep quality compared with placebo...
September 2018: Drugs
Yumin Ma, Xueyao Han, Xianghai Zhou, Yufeng Li, Siqian Gong, Simin Zhang, Xiaoling Cai, Lingli Zhou, Yingying Luo, Meng Li, Wei Liu, Xiuying Zhang, Qian Ren, Linong Ji
PURPOSE: To estimate the prevalence of glucokinase variant-induced diabetes (GCK-DM) in a general population and to establish a clinical strategy for identifying GCK-DM from type 2 diabetes (T2DM). METHODS: A population-based study of diabetes in a rural region of Beijing, China, was conducted using two-stage stratified random cluster sampling. The glucokinase exons were sequenced in patients with diabetes. RESULTS: A total of 3345 subjects, including 545 patients with diabetes, participated in this study...
September 24, 2018: Genetics in Medicine: Official Journal of the American College of Medical Genetics
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