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adult-onset diabetes

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https://www.readbyqxmd.com/read/30102631/gastric-bypass-surgery-reduces-de-novo-cases-of-type-2-diabetes-to-population-levels-a-nationwide-cohort-study-from-sweden
#1
Olof Backman, Gustaf Bruze, Ingmar Näslund, Johan Ottosson, Richard Marsk, Martin Neovius, Erik Näslund
OBJECTIVE: The aim of this study was to determine long-term changes in pharmacological treatment of type 2 diabetes after primary Roux-en-Y gastric bypass (RYGB) surgery, in patients with and without pharmacological treatment of diabetes preoperatively. SUMMARY OF BACKGROUND DATA: Several studies have shown that gastric bypass has good effect on diabetes, at least in the short-term. This study is a nationwide cohort study using Swedish registers, with basically no patients lost to follow-up during up to 7 years after surgery...
August 10, 2018: Annals of Surgery
https://www.readbyqxmd.com/read/30090730/prevalence-of-pediatric-metabolic-syndrome-and-associated-risk-factors-among-school-age-children-of-10-16-years-living-in-district-shimla-himachal-pradesh-india
#2
Anmol Gupta, Amit Sachdeva, Narender Mahajan, Aakriti Gupta, Neha Sareen, Ravindra Mohan Pandey, Lakshmy Ramakrishnan, Hem Chandra Sati, Brij Sharma, Neetu Sharma, Umesh Kapil
Introduction: Recently, an increasing trend in the prevalence of pediatric metabolic syndrome (PMS) among school-age children has been documented in different parts of India. There is lack of data on the prevalence of PMS and its associated risk factors among school-age children living in district Shimla, Himachal Pradesh. Hence, to fill in the gap in the existing knowledge, the present study was conducted. Methodology: A cross-sectional study was conducted during 2015-2016...
May 2018: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/30079149/new-onset-diabetes-after-kidney-transplantation-incidence-and-associated-factors
#3
Vânia Gomes, Florbela Ferreira, José Guerra, Maria João Bugalho
AIM: To determine the incidence and associated factors of new-onset diabetes after transplantation (NODAT) in a Portuguese central hospital. METHODS: This single-center retrospective study involved consecutive adult nondiabetic transplant recipients, who had undergone kidney transplantation between January 2012 and March 2016. NODAT was diagnosed according to the criteria of the American Diabetes Association. Data were collected from an institutional database of the Nephrology and Kidney Transplantation Department (Santa Maria Hospital, Lisbon, Portugal) and augmented with data of laboratorial parameters collected from the corresponding patient electronic medical records...
July 15, 2018: World Journal of Diabetes
https://www.readbyqxmd.com/read/30075179/platelet-count-and-8-year-incidence-of-diabetes-the-korean-genome-and-epidemiology-study
#4
Jin-Young Hwang, Yu-Jin Kwon, Won-Jun Choi, Dong-Hyuk Jung
AIMS: The aim of this study is to investigate the effect of platelet count on the incidence of type 2 diabetes mellitus (DM) in the overall Korean adults and in participants with impaired glucose tolerance (IGT) at baseline. METHODS: A total of 7,502 participants (3,528 men and 3,974 women) aged 40 to 69 years were enrolled in this study. The study population was divided into tertiles (T) of serum platelet counts. We used Cox regression to analyse the relationship between baseline platelet count and new-onset type 2 DM...
July 31, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/30074090/implementation-of-effective-transition-from-pediatric-to-adult-diabetes-care-epidemiological-and-clinical-characteristics-a-pioneering-experience-in-north-africa
#5
Leïla Essaddam, Wafa Kallali, Manel Jemel, Hager Kandara, Inès Kammoun, Mohamed Hsairi, Leïla Ben Salem, Saayda Ben Becher
AIMS: Type 1 diabetes is increasing in children leading more T1D young adults to adult healthcare settings. This change is experienced as a tear and results in a disengagement from specialist services. This study reports on an implementation of an effective and pioneering program of transition in North Africa. METHODS: A total of 65 teenagers with T1D were recruited for a structured program of transition. They attend transitional meetings involving both pediatric and adult team and were, when ready, welcomed in specialized consultations for adolescents with a special « passport »...
August 3, 2018: Acta Diabetologica
https://www.readbyqxmd.com/read/30073765/persistent-elevations-in-circulating-ins-dna-among-subjects-with-longstanding-type-1-diabetes
#6
Anna Neyman, Jennifer Nelson, Sarah Tersey, Raghavendra G Mirmira, Carmella Evans-Molina, Emily K Sims
AIMS: DNA release by dying β cells leads to increased circulating levels of unmethylated preproinsulin (INS) DNA. Consistent with large-scale β cell destruction, this biomarker is elevated before and at the time of type 1 diabetes (T1D) onset. We measured serum INS DNA to evaluate whether β cells continue to undergo death in later stages of T1D. MATERIALS AND METHODS: We analyzed fasting banked sera from a cross-section of 90 participants in the T1D Exchange Registry with long standing T1D (median duration of 9 years)...
August 2, 2018: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/30072401/trajectory-of-disability-in-older-adults-with-newly-diagnosed-diabetes-role-of-elevated-depressive-symptoms
#7
Chao-Yi Wu, Lauren Terhorst, Jordan F Karp, Elizabeth R Skidmore, Juleen Rodakowski
OBJECTIVE: We examined whether the trajectory of disability differed between older adults with and without elevated depressive symptoms before and after the onset of diabetes mellitus (DM) over 10 years (2004-2014) and explored difficulties in basic and instrumental activities of daily living between the two groups. RESEARCH DESIGN AND METHODS: A generalized linear mixed-model analysis was conducted using five waves (8th-12th) of Health and Retirement Study (HRS) data...
August 2, 2018: Diabetes Care
https://www.readbyqxmd.com/read/30071743/sleep-lifestyle-behaviors-and-cardiometabolic-health-markers-in-overweight-obese-young-adults-a-pilot-study-using-the-sensewear%C3%A2-armband
#8
EunSeok Cha, Molly Sarah Talman, Ann H Massey, Fengxia Yan, Ann E Rogers
AIM: This pilot study examined associations between sleep quality and metabolic risk profiles, underlying hormones, inflammatory markers, and behaviors in overweight and obese young adults, aged 18-29 years. DESIGN: Cross-sectional, descriptive, correlational study design. METHOD: A partial sample ( n = 29) was re-recruited from a parent study on screening for risk of early-onset diabetes. BodyMedia's SenseWear® armband was used to assess sleep quality...
August 2, 2018: Biological Research for Nursing
https://www.readbyqxmd.com/read/30064602/subcutaneous-granuloma-annulare
#9
Tatiana Ţăranu, Mirela Grigorovici, Magda Constantin, Mihaela Paula Toader
Dear Editor, Subcutaneous granuloma annulare (SGA) is considered a rare clinical variant of granuloma annulare, a common self-healing chronic inflammatory disorder that may appear in childhood as well as in adult age (1-3). A 29-year-old female patient reported the onset of several small subcutaneous nodules on the dorsal aspect of the second interphalangeal joint of the left medius finger and the left elbow, accompanied by vague joint pain, had occurred 13 years ago. Specific markers for rheumatoid arthritis were negative, leading to a diagnosis of sero-negative rheumatoid arthritis, for which treatment with methotrexate was initiated...
December 2017: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/30058495/type-1-diabetes-related-autoantibodies-in-different-forms-of-diabetes
#10
Elin Pettersen Sorgjerd
Autoantibodies against Glutamic Acid Decarboxylase (GADA), insulinoma antigen-2 (IA-2A), insulin (IAA) and the most recently Zinc transporter 8 (ZnT8A) are one of the most reliable biomarkers for autoimmune diabetes in both children and adults. They are today the only biomarkers that can distinguish Latent autoimmune diabetes in adults (LADA) from phenotypically type 2 diabetes. As the frequency of autoantibodies at diagnosis in childhood type 1 diabetes depends on age, GADA is by far the most common in adult onset autoimmune diabetes, especially LADA...
July 29, 2018: Current Diabetes Reviews
https://www.readbyqxmd.com/read/30057913/risk-factors-for-microvascular-complications-of-diabetes-in-a-high-risk-middle-east-population
#11
Sohaila Cheema, Patrick Maisonneuve, Mahmoud Zirie, Amin Jayyousi, Hekmat Alrouh, Amit Abraham, Sura Al-Samraye, Ziyad Mahfoud, Ibrahim Mohammed Al-Janahi, Buthaina Ibrahim, Albert B Lowenfels, Ravinder Mamtani
Aims: Much of the diabetes burden is caused by its complications. This cross-sectional study aimed to determine the prevalence and risk factors for diabetic microvascular complications (retinopathy, nephropathy, and neuropathy) in a high-risk population. Methods: We collected information via a structured questionnaire and directly from the patient's record on 1034 adult type 2 diabetic patients who were attending outpatient clinics in Qatar. Results: The mean age of the patients was 55 ± 10 years, and the mean duration of diabetes was 12...
2018: Journal of Diabetes Research
https://www.readbyqxmd.com/read/30055905/risk-factors-for-decline-in-renal-function-among-young-adults-with-type-1-diabetes
#12
Anke Schwandt, Dominik Bergis, Michael Denkinger, Katja S C Gollisch, Dirk Sandig, Harald Stingl, Stefan Zimny, Reinhard W Holl
AIMS: To investigate risk factors for declining renal function among subjects with type-1-diabetes. METHODS: Observational study based on data from the diabetes registry DPV. 4424 type-1-diabetes subjects aged ≥18 years, age at onset <18 years were identified. Modification of Diet in Renal Disease (MDRD) equation was used to estimate glomerular filtration rate (eGFR). Annual rate of renal decline was estimated for each patient using hierarchic linear regression models...
July 19, 2018: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/30042730/poor-sleep-and-obesity-concurrent-epidemics-in-adolescent-youth
#13
REVIEW
Anisha Gohil, Tamara S Hannon
Poor sleep and obesity are both extraordinarily common in the US adolescent population and often occur simultaneously. This review explores the links between obesity and sleep, outlining what is known about the relationships between sleep characteristics, obesity, and cardiometabolic risk factors in youth. Sleep duration is less than optimal in teens, and decreases as age increases. This is detrimental to overall well-being and is associated with obesity in children, adolescents, and young adults. Accordingly, inadequate sleep duration is associated with poor diet quality, decreased insulin sensitivity, hyperglycemia, and prevalent cardiometabolic risk factors...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/30036974/visits-to-pediatric-clinics-by-adult-patients-a-nationwide-survey-in-taiwan
#14
Kang-Lung Lee, An-Min Lynn, Tzeng-Ji Chen, Ling-Yu Yang, Shu-Chiung Chiang
Pediatricians are trained to provide non-surgical medical care to children. Improvements in medical treatments and surgical techniques have extended the survival of children with congenital diseases and chronic illnesses. Consequently, pediatricians may provide continuous medical service to their patients into adulthood. Meanwhile, as Taiwan's birth rate has fallen to one of the lowest in the world, pediatricians are encountering growing competition. As a source of continued revenue, pediatricians could also provide medical care to adults with common diseases and patients with adult-onset chronic diseases...
July 20, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/30029154/substance-use-among-older-adults-with-bipolar-disorder-varies-according-to-age-at-first-treatment-contact
#15
Osvaldo P Almeida, Graeme J Hankey, Bu B Yeap, Jonathan Golledge, Leon Flicker
BACKGROUND: The use of alcohol and drugs is common among people with bipolar disorder, but it is unclear if age of onset modifies this association. AIMS: To determine the cross-sectional and longitudinal association between age of onset of bipolar disorder (BD) and disorders associated with the use of alcohol or other substances in later life, as well as their impact on mortality. METHODS: Cohort study of a community-representative sample of 38,173 men aged 65-85 years at the start of the follow up period of 18 years...
July 17, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/30022421/early-onset-of-obesity-and-adult-onset-of-obesity-as-factors-affecting-patient-characteristics-prior-to-bariatric-surgery
#16
Małgorzata Wrzosek, Klaudia Wiśniewska, Ada Sawicka, Marek Tałałaj, Grażyna Nowicka
BACKGROUND: Patients who are slated for bariatric surgery vary in terms of their age at onset of obesity, duration of obesity, and their health complications. Therefore, we aimed to explore a relationship between the age at onset of obesity, metabolic parameters, and health problems in bariatric surgery candidates. METHODS: A total of 469 unrelated adults with obesity prior to bariatric surgery were included in this study. The study group consisted of 246 individuals who became obese < 20 years of age, and 223 individuals who became obese ≥ 20 years...
July 18, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/30018100/qualitative-study-of-barriers-to-clinical-trial-retention-in-adults-with-recently-diagnosed-type-1-diabetes
#17
Catherine Henshall, Parth Narendran, Robert C Andrews, Amanda Daley, Keith A Stokes, Amy Kennedy, Sheila Greenfield
OBJECTIVES: Regular physical exercise may preserve β cell function in newly diagnosed adults with type 1 diabetes (T1D). However, clinical trials to test this theory require the recruitment and retention of adults with new-onset T1D, which can be challenging. We sought to determine the overall experiences of newly diagnosed adults with T1D in an exercise study, to understand issues that influence the retention of trial participants in such studies. DESIGN: Qualitative methodology using individual face-to-face (n=6) and telephone interviews (n=14)...
July 17, 2018: BMJ Open
https://www.readbyqxmd.com/read/30015397/older-men-with-bipolar-disorder-clinical-associations-with-early-and-late-onset-illness
#18
Osvaldo P Almeida, Graeme J Hankey, Bu B Yeap, Jonathan Golledge, Leon Flicker
OBJECTIVES: Older adults living with bipolar disorder (BD) include people with early and late onset of symptoms. This study aimed to clarify the cross-sectional and longitudinal clinical associations of BD with early and late onset. METHODS: Cohort study of 38 173 men aged 65-85 years followed for up to 17.6 years. We used the Western Australian Data Linkage System to establish the presence of BD, as well as diabetes, cardiovascular and renal diseases, cancer, respiratory and gastrointestinal diseases, alcohol use disorder, dementia, and mortality...
July 17, 2018: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/30012268/exposure-to-improved-nutrition-from-conception-to-age-2-years-and-adult-cardiometabolic-disease-risk-a-modelling-study
#19
Nicole D Ford, Jere R Behrman, John F Hoddinott, John A Maluccio, Reynaldo Martorell, Manuel Ramirez-Zea, Aryeh D Stein
BACKGROUND: Low-income and middle-income countries with populations that are chronically undernourished in early life are undergoing a nutrition transition and are experiencing an epidemic of cardiometabolic disease. These dual burdens are thought to be causally related; therefore, the extent to which improvements in early-life nutrition can offset adult-onset disease is important. The aim of this study was to examine whether improvement of protein-energy nutrition from conception to age 2 years can attenuate the risk of cardiometabolic disease...
August 2018: Lancet Global Health
https://www.readbyqxmd.com/read/30007277/functional-characteristics-of-novel-pancreatic-pax6-regulatory-elements
#20
Adam Buckle, Ryu-Suke Nozawa, Dirk A Kleinjan, Nick Gilbert
Complex diseases, such as diabetes, are influenced by comprehensive transcriptional networks. Genome-wide association studies have revealed that variants located in regulatory elements for pancreatic transcription factors are linked to diabetes, including those functionally linked to the paired box transcription factor, Pax6. Pax6 deletions in adult mice cause rapid onset of classic diabetes, but the full spectrum of pancreatic Pax6 regulators is unknown. Using a regulatory element discovery approach we identified two novel Pax6 pancreatic cis-regulatory elements in a poorly characterised regulatory desert...
July 11, 2018: Human Molecular Genetics
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