Read by QxMD icon Read


Susan P Knowler, Gabriel L Galea, Clare Rusbridge
Chiari-like Malformation (CM) and secondary syringomyelia (SM), as well as their analogous human conditions, is a complex developmental condition associated with pain and accompanying welfare concerns. CM/SM is diagnosed ever more frequently, thanks in part to the increased availability of magnetic resonance imaging in veterinary medicine. Research over the last two decades has focused primarily on its pathophysiology relating to overcrowding of the cranial caudal fossa. More recent characterizations of CM/SM include brachycephaly with osseous reduction and neural parenchymal displacement involving the entire brain and craniocervical junction to include rostral flattening, olfactory bulb rotation, increased height of the cranium, reduced cranial base with spheno-occipital synchondrosis angulation, reduced supraoccipital and interparietal crest and rostral displacement of the axis and atlas with increased odontoid angulation...
2018: Frontiers in Veterinary Science
Alan Marionneaux, Joshua Walters, Helena Guo, Jeremy Mercuri
Focal chondral and osteochondral defects create significant pain and disability for working-aged adults. Current osteochondral repair grafts are limited in availability and often fail due to insufficient osseous support and integration. Thus, a need exists for an off-the-shelf osteochondral construct with the propensity to overcome these shortcomings. Herein, a scalable process was used to develop a multi-layered osteochondral graft with a subchondral bone (ScB) phase tailored to support bone healing and integration...
August 9, 2018: Acta Biomaterialia
João Augusto Vianna Goulart-Filho, Victor Angelo Martins Montalli, Fabrício Passador-Santos, Andresa Borges Soares, Ney Soares de Araújo, Vera Cavalcanti de Araújo
Considered as an aggressive counterpart of central ossifying fibroma (OF), juvenile ossifying fibroma (JOF) is a benign fibro-osseous neoplasm characterized by an unpredictable destructive behavior, elevated morbidity, mutilating treatment and high potential for local recurrences. The aim of this study is to compare the analysis for cell proliferation and vascular markers between JOF and OF. Cell proliferation index was measured by Ki-67 and Mcm-2 expression and microvessel density (MVD) was obtained by the immunoexpression of CD34/CD105...
August 4, 2018: Annals of Diagnostic Pathology
Brendan M Lawson, Shilpa G Reddy, Nicole M Jody
No abstract text is available yet for this article.
August 1, 2018: JAMA Ophthalmology
Thomas Mittlmeier, Stefan Rammelt
Subtalar joint stability is ensured by the osseous geometry of the talocalcaneal joint and the complex array of the ligaments at the medial and lateral aspect of the ankle joint, the sinus and canalis tarsi, and the talocalcaneonavicular joint, respectively. There is still a substantial lack of knowledge about the interaction of the ankle and subtalar joint complex. Subtalar joint instability appears to be more frequent than is generally assumed. The diagnosis of chronic subtalar joint instability makes the application of a comprehensive algorithm necessary...
September 2018: Foot and Ankle Clinics
Rocío Fuente, Helena Gil-Peña, Débora Claramunt-Taberner, Olaya Hernández-Frías, Ángela Fernández-Iglesias, Francisco Hermida-Prado, Gonzalo Anes-González, Isabel Rubio-Aliaga, Jose Manuel Lopez, Fernando Santos
Mechanisms underlying growth impairment and bone deformities in X-linked hypophosphatemia are not fully understood. We here describe marked alterations in the structure, dynamics and maturation of growth plate in growth-retarded young Hyp mice, in comparison with wild type mice. Hyp mice exhibited reduced proliferation and apoptosis rates of chondrocytes as well as severe disturbance in the process of chondrocyte hypertrophy disclosed by abnormal expression of proteins likely involved in cell enlargement, irregular chondro-osseous junction and disordered bone trabecular pattern and vascular invasion in the primary spongiosa...
August 7, 2018: Bone
Ivan H Wong, John Paul King, Gordon Boyd, Michael Mitchell, Catherine Coady
BACKGROUND: The Latarjet procedure for autograft transposition of the coracoid to the anterior rim of the glenoid remains the most common procedure for reconstruction of the glenoid after shoulder instability. The anatomic glenoid reconstruction using distal tibial allograft has gained popularity and is suggested to better match the normal glenoid size and shape. However, concerns about decreased healing and increased resorption arise when an allograft bone is used. PURPOSE: To use radiological findings to evaluate the arthroscopic reconstruction of the glenoid with respect to the size, shape, healing, and resorption of coracoid autograft versus distal tibial allograft...
August 10, 2018: American Journal of Sports Medicine
Hiroki Ushirozako, Tomohiko Hasegawa, Shigeto Ebata, Hiroki Oba, Tetsuro Ohba, Keijiro Mukaiyama, Yukihiro Isogai, Eisaku Okada, Toshiyuki Ojima, Jun Takahashi, Hirotaka Haro, Yukihiro Matsuyama
STUDY DESIGN: A multicenter case control study. OBJECTIVE: To investigate the independent predictors of osseous union after posterior lumbar interbody fusion (PLIF). SUMMARY OF BACKGROUND DATA: PLIF is usually performed to treat lumbar degenerative diseases in elderly patients. Some patients exhibit intervertebral pseudoarthrosis. METHODS: We analyzed 66 elderly patients with osteoporosis who underwent PLIF from 2011 to 2014 (all women, mean age 71 years, follow-up period ≥6 months)...
August 7, 2018: Spine
Jonathan G Eastman, Milton L Chip Routt
The superior ramus is an irregularly shaped, undulating, and curvilinear osseous structure that can provide an osseous conduit for intramedullary screws. A wide spectrum of variability between the curve and obliquity of the superior ramus osseous fixation pathway (OFP) exists in both the anteroposterior and the coronal planes. A detailed understanding of the osseous topography and how it correlates with fluoroscopic imaging is mandatory. Obtaining the correct intraoperative inlet and combined obturator oblique-outlet fluoroscopic views specific to each patient's anatomy is necessary for safe implant insertion...
September 2018: Journal of Orthopaedic Trauma
L L E Whitehouse, C E L Smith, J A Poulter, C J Brown, A Patel, T Lamb, L R Brown, E A O'Sullivan, R E Mitchell, I R Berry, R Charlton, C F Inglehearn, A J Mighell
OBJECTIVES: Variants in DLX3 cause Tricho-dento-osseous syndrome (TDO, MIM #190320); a, systemic condition with hair, nail and bony changes, taurodontism and amelogenesis imperfecta (AI), inherited in an autosomal-dominant fashion. Different variants found within this gene are associated with different phenotypic presentations. To date, 6 different DLX3 variants have been reported in TDO. The aim of this paper is to explore and discuss three recently uncovered new variants in DLX3. SUBJECTS AND METHODS: Whole exome sequencing identified a new DLX3 variant in one family, recruited as part of an on-going study of genetic variants associated with AI...
August 10, 2018: Oral Diseases
Daniel Talmaceanu, Lavinia Manuela Lenghel, Nicolae Bolog, Mihaela Hedesiu, Smaranda Buduru, Horatiu Rotar, Mihaela Baciut, Grigore Baciut
The diagnosis and management of temporomandibular disorders (TMD) require both clinical and imaging examinations of the temporomandibular joint (TMJ). A variety of modalities can be used to image the TMJ, including magnetic resonance imaging (MRI), computed tomography (CT), cone beam CT, ultrasonography, conventional radiography. The present review outlines the indications of the most frequently used imaging techniques in TMD diagnosis. Because of the anatomic complexity of the TMJ, imaging can be difficult...
July 2018: Clujul Medical (1957)
Sabreen Mkalaluh, Marcin Szczechowicz, Saeed Torabi, Anton Sabashnikov, Ahmed Mashhour, Matthias Karck, Alexander Weymann
BACKGROUND:  Cardiac metastases are more common than primary malignant tumors of the heart and are usually treated surgically as a palliative approach. In this study, we reviewed our experience with the surgical treatment of patients with cardiac metastases of various types of malignant tumors. METHODS:  Between 2003 and 2016, 10 patients underwent surgery for cardiac metastases at our institution. RESULTS:  The mean age was 53.5 ± 19 years...
August 9, 2018: Thoracic and Cardiovascular Surgeon
Hang Feng, Haoxi Li, Zhaoyu Ba, Zhaoxiong Chen, Xinhua Li, Desheng Wu
PURPOSE: Accurate and comprehensive data on cervical endplates is essential for developing and improving cervical devices. However, current literature on vertebral disc geometry is scarce or not suitable. The aim of this study was to obtain quantitative parameters of cervical endplates and provide morphometric references for designing cervical devices. METHODS: In this study, 19 human cervical spine cadaveric specimens were considered. Employing a reverse engineering system, the surface information of each endplate was recorded in digital cloud and then 3D reconstructed...
August 9, 2018: International Orthopaedics
Alexander Ritz Mait, Jason Lee Forman, Bingbing Nie, John Paul Donlon, Adwait Mane, Ali Reza Forghani, Robert B Anderson, M Truitt Cooper, Richard W Kent
Background: Forced external rotation of the foot is a mechanism of ankle injuries. Clinical observations include combinations of ligament and osseous injuries, with unclear links between causation and injury patterns. By observing the propagation sequence of ankle injuries during controlled experiments, insight necessary to understand risk factors and potential mitigation measures may be gained. Hypothesis: Ankle flexion will alter the propagation sequence of ankle injuries during forced external rotation of the foot...
June 2018: Orthopaedic Journal of Sports Medicine
Sachin C Sarode, Gargi S Sarode, Yashwant Ingale, Manjusha Ingale, Barnali Majumdar, Nilesh Patil, Shankargouda Patil
Juvenile ossifying fibroma is a benign fibro-osseous lesion commonly affecting the extra-gnathic craniofacial skeleton of the young individuals. The psammomatoid and trabecular variants are its two histopathological subtypes having distinctive clinico-pathological characteristics. Secondary aneurysmal bone cysts are frequently reported to arise in the pre-existing fibro-osseous lesions but rarely reported in the psammmomatoid variant of the juvenile ossifying fibroma. Such hybrid lesions, especially massive in size, tend to exhibit a greater aggressive growth potential and higher recurrence rate and mandate complete surgical removal of the lesion along with a long-term follow-up...
July 10, 2018: Clinics and Practice
Bipasha Mukherjee, Uma Devi
Ossifying fibroma (OF) is a benign fibro-osseous neoplasm which may be mistaken for other similar lesions due to overlapping clinical and radiological features. We report a 5-year-old male child with recurrent benign OF of the orbit. The child had two episodes of recurrence in a span of 18 months. Computed tomography (CT) of orbit showed a large, lobulated expansile fibro-osseous lesion involving the greater wing of sphenoid and orbital roof without intracranial extension. An excisional biopsy was done though an orbital approach...
August 8, 2018: Orbit
Alberto Consolaro, Sergio Rafael Baggio Paschoal, Jose Burgos Ponce, Dario A Oliveira Miranda
Florid cemento-osseous dysplasia is a sclerosing disease that affects the mandible, especially the alveolar process, and that is, in most cases, bilateral; however, in some cases it affects up to three or even four quadrants. During the disease, normal bone is replaced with a thinly formed, irregularly distributed tissue peppered with radiolucent areas of soft tissue. Newly formed bone does not seem to invade periodontal space, but, in several images, it is confused with the roots, without, however, compromising pulp vitality or tooth position in the dental arch...
May 2018: Dental Press Journal of Orthodontics
Cyrus Ayubcha, Mahdi Zirakchian Zadeh, Mette J Stochkendahl, Abdullah Al-Zagha, Jan Hartvigsen, Chamith S Rajapakse, William Raynor, Thomas Werner, Anders Thomassen, Hongming Zhuang, Poul F Høilund-Carlsen, Abass Alavi
OBJECTIVE: The aim of this study was to describe osseous metabolic activity with respect to age and weight in the spine as expressed through fluorine-18-sodium fluoride (F-NaF) uptake in a healthy male population. PARTICIPANTS AND METHODS: Whole-body F-NaF PET/CT scans of healthy male participants (22-71 years, 50-145 kg, n=47) were analysed using a global assessment methodology to derive the mean standardized uptake values (SUVmean). Individual regions of the spine (cervical, thoracic and lumbar) along with the aggregate whole spine were assessed and compared as potential functions of age and body weight...
August 6, 2018: Nuclear Medicine Communications
Ritesh Panda, Mahesh Mangal, Sasidhar Reddy, Anubhav Gupta, Swaroop Singh Gambhir, Bheem Singh Nanda
We describe a case of intramuscular vascular malformation with extensive ossification within the posterior compartment muscles of leg which grossly mimicked long bone leading to equinus deformity of foot. Phleboliths and calcifications are characteristic of vascular malformations, while massive ossification is rare. To our knowledge, no extensive ossified vascular malformation within the leg muscle has been reported. Intramuscular vascular lesions occur with an incidence of 0.8%, most frequent in upper and lower extremities...
May 2018: World Journal of Plastic Surgery
Christian Fischer, Tabea Haug, Marc-Andre Weber, Hans-Ulrich Kauczor, Thomas Bruckner, Gerhard Schmidmaier
PURPOSE:  To assess the value of CEUS in the evaluation of tibial fracture perfusion and its ability to differentiate between physiologic and abnormal fracture healing. MATERIALS AND METHODS:  From 2014 to 2017, 107 patients with tibial fractures or tibial non-unions underwent CEUS examination. CEUS was performed at the regular follow-up examination 26 weeks after osteosynthesis or before non-union surgery. Time-intensity curves (TICs) of the contrast enhancement in the fracture gap were generated, and volume parameters such as wash-in rate (WiR), peak enhancement (PE) and wash-in perfusion index (WiPI) were quantified...
August 6, 2018: Ultraschall in der Medizin
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"