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Namra Asghar, Aamna Hassan
Bone metastases in HCC are uncommon with an incidence of 3% to 20%. Screening for bone metastasis is not a routine practice. Diagnosis is often delayed, and usually made once symptoms develop.
September 2018: JPMA. the Journal of the Pakistan Medical Association
Ramesh Sethy, Radhakrishnan Rakesh, Ketki Patne, Vijendra Arya, Tapan Sharma, Dominic Thangminlen Haokip, Reshma Kumari, Rohini Muthuswami
The G2/M checkpoint is activated on DNA damage by the ATM and ATR kinases that are regulated by post-translational modifications. In this paper, the transcriptional co-regulation of ATM and ATR by SMARCAL1 and BRG1, both members of the ATP-dependent chromatin remodeling protein family, is described. SMARCAL1 and BRG1 co-localize on the promoters of ATM and ATR; downregulation of SMARCAL1 and BRG1 results in transcriptional repression of ATM/ATR and overriding of the G2/M checkpoint leading to mitotic abnormalities...
October 11, 2018: Biochimica et biophysica acta. Gene regulatory mechanisms
Eric Shi, Ryan Carter, Glenn M Weinraub
Foot and ankle surgeons continue to explore bone graft alternatives that will be comparable to the reference standard of autologous bone. The purpose of the present study was to consider the outcomes of hindfoot arthrodesis supplemented with bioactive glass in patients at risk of delayed union and nonunion. We performed a retrospective radiographic review of 29 consecutive patients (48 joints) who had undergone arthrodesis of ≥1 joint of the hindfoot (ankle, subtalar, talonavicular, calcaneocuboid). All patients included in the present study had a minimum of 1 documented risk factor for osseous nonunion (history of previous nonunion, trauma, smoking, diabetes, Charcot arthropathy, obesity, age >65 years at surgery)...
October 10, 2018: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
Lee Daffin, Max C Stuelcken, Mark G L Sayers
BACKGROUND: Recent research highlighted that non-lordotic subtypes are common within an asymptomatic population of young adults. The potential mechanisms responsible for the decreased postural control witnessed in healthy participants exhibiting non-lordotic cervical alignment are unclear. RESEARCH QUESTION: Therefore, the aim of this study is to compare and contrast asymptomatic radiographically derived sagittal cervical alignment subtypes with Center of Pressure (CoP) parameters...
October 1, 2018: Gait & Posture
Florian B Imhoff, Matthias Cotic, Franz Liska, Felix G E Dyrna, Knut Beitzel, Andreas B Imhoff, Elmar Herbst
PURPOSE: Increased femoral antetorsion influences patellofemoral joint kinematics. The aim of this study was to retrospectively evaluate the clinical outcome after derotational osteotomies and combined procedures in patients with patellofemoral instability. METHODS: All patients with derotational osteotomies and combined procedures in patients with patellofemoral instability and increased femoral antetorsion performed between 2007 and 2016 were retrospectively analyzed...
October 13, 2018: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
Yang-Quan Hao, Hao Guo, Tian Zhu, Zhao-Chen Xu, Han-Deng Qi, Chao Lu, Pu-Wei Yuan
The aim of this study was to evaluate the clinical effect of core decompression (CD), lesion clearance, and bone graft in combination with Tongluo Shenggu decoction for the treatment of osteonecrosis of the femoral head (ONFH).A total of 75 patients (92 hips), with ONFH at Association Research Circulation Osseous (ARCO) stages II to IIIA, were studied and divided into treatment group and control group. In control group, patients were treated with the CD in combination with autologous or artificial ceramic bone graft...
October 2018: Medicine (Baltimore)
Dayana P Rosa, Paula R Camargo, John D Borstad
OBJECTIVES: To assess the influence of posterior capsule tightness and humeral retroversion on shoulder motion measurements. DESIGN: Cross-Sectional study. SETTING: Controlled university laboratory. PARTICIPANTS: 75 asymptomatic individuals were assigned to one of 4 groups: control (n = 28); posterior capsule tightness only (n = 17); humeral retroversion only (n = 15); and combined posterior capsule tightness and retroversion (n = 15)...
October 4, 2018: Physical Therapy in Sport
Tariq Jawadi, Feras AlShomer, Muhammed Al-Motairi, Abdullah Al-Qahtani, Mohammad Alfowzan, Obaid Almeshal
Background: Fibro-osseous pseudotumor (FOPD) of the digit is a rare benign lesion of subcutaneous tissue characterized by fibroblastic proliferation and osteoid formation. Herein, we present a case of massive FOPD lesion in the base of ring finger with extensive involvement of the neurovascular bundles with challenging surgical approach. Case description: A 27-year old female patient, presented with 7-months history of a progressively enlarging mass on her left hand...
November 2018: Annals of Medicine and Surgery
Omar M Albtoush, Marius Horger, Fabian Springer, Jan Fritz
The Segond fracture is a tibial avulsion injury of the insertion of the middle third of the lateral capsular ligament that is typically associated with anterior cruciate ligament and meniscal tears. The classically assigned mechanism of injury is a combination of internal rotation and varus stress. We report two cases of Segond fractures that presented with a variant pattern including osseous avulsion injuries of the medial collateral ligament at the femoral origin, anterior cruciate ligament tear, and pivot shift-type osseous contusion pattern, suggesting an alternative mechanism of injury that includes dominant valgus stress and external rotation components...
September 11, 2018: Clinical Imaging
Mona Hamdy, Niveen Salama, Ghada Maher, Amira Elrefaee
Lower levels of vitamin D have been documented in many patients with sickle cell disease (SCD), but data are still inconclusive regarding the association between vitamin D deficiency (VDD) and the occurrence or the severity of various SCD complications. Our study aimed to detect the prevalence of vitamin D deficiency among Egyptian patients with SCD and to associate it with the clinical course of the disease. We measured the level of 25-hydroxy vitamin D in 140 children (age from 4.3 to 15.5years), 80 patients with SCD and 60 controls using enzyme-linked immunosorbent assay...
2018: Advances in Hematology
Patrick Haubruck, Anja Solte, Raban Heller, Volker Daniel, Michael Tanner, Arash Moghaddam, Gerhard Schmidmaier, Christian Fischer
BACKGROUND: Despite the regenerative capability of skeletal tissue fracture, non-union is common. Treatment of non-unions remains challenging, and early determination of the outcome is impossible. Chemokines play an important role in promoting the formation of new bone and remodeling existing bone. Despite their importance regarding the regulation of bone biology, the potential of chemokines as biological markers reflecting osseous regeneration is unknown. The purpose of this study was to determine (1) if serum chemokine expression levels correlate with the outcome of non-union surgery and (2) if chemokine expression analysis can be used to identify patients at risk for treatment failure...
October 10, 2018: Journal of Orthopaedic Surgery and Research
Kate E Elzinga, John R Lien
CASE: A 31-year-old Caucasian man presented with a greater arc perilunate variant injury after falling from a friend's shoulders onto an outstretched hand. Imaging revealed a minimally displaced scaphoid waist fracture and a nondisplaced transverse fracture through a previously unrecognized lunotriquetral coalition. A volar intercalated segmental instability (VISI) deformity was present. Open reduction with osseous fixation (a headless compression screw for the scaphoid waist fracture and 3 Kirschner wires across the midcarpal joint) and repair of the torn volar ligaments partially restored the carpal alignment...
October 10, 2018: Journal of Bone and Joint Surgery. American Volume
Maria Pilar Aparisi Gómez, Francisco Aparisi, Alberto Bazzocchi
62-year-old male, consulting for ongoing pain in the right shoulder, noticeable on performance of daily tasks. Physical examination demonstrates generalized pain with mobilization, more marked with external rotation, and limited abduction, with a mechanical block at 60 degrees. Oblique-Sagittal Short-TI inversion recovery (STIR) (figure 1) demonstrates a low signal intensity structure at the footprint of the infraspinatus (white arrow). This has an extra and an intraosseous component, resembling an hourglass...
October 10, 2018: Arthritis & Rheumatology
Francesco Gaudio, Pasquale Pedote, Artor Niccoli Asabella, Giuseppe Ingravallo, Paola Sindaco, Vito Alberotanza, Tommasina Perrone, Fiomena Emanuela Laddaga, Giuseppe Rubini, Amato Antonio Stabile Ianora, Giorgina Specchia
Hodgkin's lymphoma (HL) is now a highly curable disease, with an improving 5-year survival rate that has now reached 86%. At the time of presentation, HL is usually almost entirely confined to the lymph nodes. We performed a retrospective single-institution study of 384 cases with a median follow-up of 44 months, with the aim of identifying clinical and radiological characteristics and outcomes of patients with bone HL; 32 patients (8%) had primary bone involvement, always with concurrent nodal disease. These included 22 men (69%) and 10 women (31%) with the median age as 41 years...
October 9, 2018: Acta Haematologica
Sebastian Hoberück, Enrico Michler, Danilo Seppelt, Jörg Kotzerke, Claudia Brogsitter
A 68-year-old woman who underwent a thyroidectomy for bilateral goiter 20 years ago was referred to our department. The examination revealed a newly occurred thyroid nodule in the right central lobe. Unexpectedly the Tc-pertechnetate scan revealed several extrathyroidal foci right-sided supraclavicular, beside a cold thyroid nodule in the right lower lobe. Consecutive surgery and histology confirmed the suspected diagnosis of follicular thyroid cancer with multiple bone metastases. Whole-body scintigraphy performed after the following radioiodine therapy indicated disseminated osseous metastases...
October 8, 2018: Clinical Nuclear Medicine
Paul S Petrungaro, Gregori M Kurtzman, Santiago Gonzales, Carlos Villegas
Treatment of severely resorbed partially or completely edentulous maxillae can include the utilization of the zygomatic process for immediate implant fixation and stabilization with immediate function. This approach may alleviate the need for significant grafting to enable implant placement in the posterior maxilla and allow implants to be placed into denser, more stable bone. Zygomatic implants, which have been used clinically for the past 20 years in the treatment of the severely resorbed maxilla, allow implant placement to support fixed prosthetics...
October 2018: Compendium of Continuing Education in Dentistry
Yi-Chou Hou, Chien-Lin Lu, Kuo-Cheng Lu
As the GFR loss aggravates, the disturbed mineral metabolism worsens the bone microstructure and remodelling - scenario, which is known as CKD-mineral bone disease (MBD). CKD-MBD is characterized by : (i) abnormal metabolism of calcium, phosphorus, parathyroid hormone (PTH), or vitamin D; (ii) abnormalities in bone turnover, mineralization, volume linear growth or strength; (iii) soft-tissue calcifications, either vascular or extra-osseous. Uremic vascular calcification and osteoporosis are the most common complications related to CKD-MBD...
October 2018: Nephrology
Anne Marie E Snoddy, Hallie R Buckley, Gail E Elliott, Vivien G Standen, Bernardo T Arriaza, Siân E Halcrow
The past two decades have seen a proliferation in bioarchaeological literature on the identification of scurvy, a disease caused by chronic vitamin C deficiency, in ancient human remains. This condition is one of the few nutritional deficiencies that can result in diagnostic osseous lesions. Scurvy is associated with low dietary diversity and its identification in human skeletal remains can provide important contextual information on subsistence strategy, resource allocation, and human-environmental interactions in past populations...
October 9, 2018: American Journal of Physical Anthropology
Farzaneh Aghajani, Somaieh Kazemnejad, Tabassom Hooshmand, Zahra Ghaempanah, Amir-Hassan Zarnani
OBJECTIVES: Despite the increased interest in stem cells isolated from remnant pulp of deciduous teeth, no specific marker has been yet established for them. The present study aimed to investigate whether SSEA-4 (stage-specific embryonic antigen) would be a suitable marker to isolate stem cells from Human Exfoliated Deciduous teeth (SHEDs) in order to increase its differentiation potential toward osseous tissue. DESIGN: The SHEDs were isolated and the expression patterns of mesenchymal, hematopoietic and embryonic stem cell markers were assessed...
September 26, 2018: Archives of Oral Biology
B Gülenç, E Kuyucu, S Yalçin, A Çakir, A M Bülbül
PURPOSE OF THE STUDY Non-osseous giant cell tumors are locally aggressive tumors arising around joints. They are commonly located around synovial joints such as wrist and knee and occasionally cause mechanical symptoms. MATERIAL AND METHODS This retrospective case series includes 7 patients operated due to intraarticular lesion. The mean age of the patients was 28.7 (range 22-37) years. Mean follow-up period was 12 months. RESULTS All patients underwent arthroscopic debridement. They were followed monthly with clinical examination and magnetic resonance imaging (MRI) was obtained at third month for all patients...
2018: Acta Chirurgiae Orthopaedicae et Traumatologiae Cechoslovaca
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