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https://www.readbyqxmd.com/read/30343377/defecatory-dysfunction-and-other-clinical-variables-are-predictors-of-pessary-discontinuation
#1
Erin G Dengler, Louisa A Mounsey, Francesca Gines, Manahil Agha, Terri Long, Elizabeth J Geller
INTRODUCTION AND HYPOTHESIS: Pessaries provide first-line therapy for women with pelvic organ prolapse (POP) and stress urinary incontinence (SUI). The primary hypothesis was that defecatory dysfunction was associated with pessary discontinuation. METHODS: This was a retrospective cohort study of all women undergoing first pessary placement at one academic center from April 2014 to January 2017. Defecatory dysfunction was defined as the presence of constipation, rectal straining, rectal splinting, and/or incomplete defecation...
October 20, 2018: International Urogynecology Journal
https://www.readbyqxmd.com/read/30340574/the-leaves-of-crataeva-nurvala-buch-ham-modulate-locomotor-and-anxiety-behaviors-possibly-through-gabaergic-system
#2
Md Moniruzzaman, Md Abdul Mannan, Md Farhad Hossen Khan, Ariful Basher Abir, Mirola Afroze
BACKGROUND: Crataeva nurvala Buch-Hum is an indigenous herb, extensively used in traditional medicines of the South Asian countries to treat inflammation, rheumatic fever, gastric irritation, and constipation. Despite this wide range of uses, very little information is known regarding its effects on the central nervous system (CNS). Therefore, this study evaluated the neuropharmacological properties of methanolic extract of Crataeva nurvala leaves (MECN) using a number of behavioral models in animals...
October 19, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/30337759/-exogenous-lipid-pneumonia-with-hyperpyrexia-a-case-report
#3
X J Wu, M Li, Q Y Zhan
Lipoid pneumonia (LP) is an uncommon form of pneumonia that is characterized by the presence of intra-alveolar lipid and lipid-laden macrophages on microscopy. It categorized as exogenous lipoid pneumonia (ExLP) and endogenous lipoid pneumonia (EnLP). Exogenous lipoid pneumonia caused by inhalation of liposuction substances (animal fat, vegetable oil, or mineral oil), mostly, in adult cases, they were medicines for constipation or rhinopharyngitis. Most of these patients showed mild clinical manifestations, and chronic medical condition...
October 18, 2018: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/30337036/constipation-beyond-the-old-paradigms
#4
REVIEW
Peter L Lu, Hayat M Mousa
Constipation is a common problem in children. Although most children respond to conventional treatment, symptoms persist in a minority. For children with refractory constipation, anorectal and colonic manometry testing can identify a rectal evacuation disorder or colonic motility disorder and guide subsequent management. Novel medications used in adults with constipation are beginning to be used in children, with promising results. Biofeedback therapy and anal sphincter botulinum toxin injection can be considered for children with a rectal evacuation disorder...
December 2018: Gastroenterology Clinics of North America
https://www.readbyqxmd.com/read/30336596/aquaporins-alteration-profiles-revealed-different-actions-of-senna-sennosides-and-sennoside-a-in-diarrhea-rats
#5
Yixin Cao, Ying He, Cong Wei, Jing Li, Lejing Qu, Huiqin Zhang, Ying Cheng, Boling Qiao
Senna and its main components sennosides are well-known effective laxative drugs and are used in the treatment of intestinal constipation in the world. Their potential side effects have attracted more attention in clinics but have little scientific justification. In this study, senna extract (SE), sennosides (SS), and sennoside A (SA) were prepared and used to generate diarrhea rats. The diarrhea rats were investigated with behaviors, clinical signs, organ index, pathological examination, and gene expression on multiple aquaporins ( Aqps ) including Aqp1 , Aqp2 , Aqp3 , Aqp4 , Aqp5 , Aqp6 , Aqp7 , Aqp8 , Aqp9 , and Aqp11 ...
October 17, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/30333269/efficacy-of-additional-solifenacin-succinate-therapy-for-storage-symptoms-in-females-with-uncomplicated-lower-urinary-tract-infection-the-solution-randomized-controlled-trial
#6
Harrina Erlianti Rahardjo, Firtantyo Adi Syahputra, Putri Iradita Islianti, Faisal Abdi Matondang
BACKGROUND: urinary tract infection (UTI) is often treated in daily practice as overactive bladder (OAB) by giving anticholinergic, the recommended treatment options of OAB. However, anticholinergic application for UTI symptoms relief has never been investigated. To our knowledge, this study was the first randomized trial which investigate anticholinergic use for UTI treatment. This study aimed to evaluate whether additional anticholinergic is beneficial alongside an empiric antibiotic therapy in reducing symptoms and tolerable for females with uncomplicated UTI...
July 2018: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/30324554/declining-rates-of-referral-for-irritable-bowel-syndrome-without-constipation-at-a-tertiary-care-center
#7
Sun Jung Oh, Vartan C Tashjian, James Mirocha, Menachem Nagar, Ruchi Mathur, Eugenia Lin, Kathleen Shari Chua, Ali Rezaie, Mark Pimentel, Nipaporn Pichetshote
BACKGROUND: Irritable bowel syndrome (IBS) is a common chronic disorder of the gastrointestinal tract. Several treatments have been developed, including rifaximin for the treatment of IBS without constipation (non-IBS-C), but no studies have evaluated the effect of these therapies on patient referral rates to tertiary care gastroenterology clinics. AIM: To assess referral patterns for IBS patients at a tertiary motility clinic over a 10-year period. METHODS: Data from consecutive patients referred to the clinic during 2006-2016 were analyzed...
October 15, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/30322606/ethnopharmacology-phytochemistry-and-pharmacology-of-sterculia-lychnophora-hance-pangdahai
#8
Mahmood Brobbey Oppong, Yang Li, Prince Osei Banahene, Shi-Ming Fang, Feng Qiu
The matured, ripen, and dried seeds of Scaphium affine (Mast.) Pierre, known as Pangdahai (PDH) in Chinese and recorded as Sterculia lychnophora Hance (scientific synonym) in the 2015 edition of the Chinese Pharmacopeia, have been widely used in traditional Chinese medicine, Japanese folk medicine, Vietnamese traditional medicine, traditional Thai medicine and Indian traditional medicine. The decoctions of the seeds are used as a remedy for pharyngitis, laryngitis, constipation, cough, menorrhagia, and pain management...
October 2018: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/30321826/intestinal-obstruction-caused-by-a-laxative-drug-psyllium-a-case-report-and-review-of-the-literature
#9
Ashraf F Hefny, Adel Z Ayad, Nikolay Matev, Masoud O Bashir
INTRODUCTION: Psyllium in granular dosage form is used as an over - the counter safe laxative drug. It has a considerable hygroscopic propriety which allows it to retain water and expands rapidly to become many times of its original size. PRESENTATION OF THE CASE: 21-year-old man presented to the Emergency Department complaining of lower abdominal pain and constipation for five days. He was discharged home on Psyllium for treatment of the constipation. Two days later, he returned to the Emergency Department complaining of increased abdominal distension without passing any stools...
October 8, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/30318190/comparison-and-assessment-of-flixweed-and-fig-effects-on-irritable-bowel-syndrome-with-predominant-constipation-a-single-blind-randomized-clinical-trial
#10
Makan Pourmasoumi, Reza Ghiasvand, Leila Darvishi, Amir Hadi, Nimah Bahreini, Ziyaaddin Keshavarzpour
BACKGROUND: Irritable bowel syndrome with predominant constipation (IBS-C) is a common digestive disorder. The current therapy is inadequate and evidence regarding the effect of herbal therapies on the relief of affected individuals is insufficient. The aim of this study was to investigate the beneficial effects of flixweed and fig consumption on IBS-C symptoms. METHODS: 150 patients with IBS-C were enrolled in this randomized, controlled trial. All patients were randomly assigned to three groups and received an intervention for four months...
September 11, 2018: Explore: the Journal of Science and Healing
https://www.readbyqxmd.com/read/30317589/chronic-kidney-disease-after-5-6-nephrectomy-disturbs-the-intestinal-microbiota-and-alters-intestinal-motility
#11
Kazuhiro Nishiyama, Kimiya Aono, Yasuyuki Fujimoto, Mitsuru Kuwamura, Toshiya Okada, Hayato Tokumoto, Takeshi Izawa, Ryoichi Okano, Hidemitsu Nakajima, Tadayoshi Takeuchi, Yasu-Taka Azuma
Organ-organ crosstalk is involved in homeostasis. Gastrointestinal symptoms are common in patients with renal failure. The aim of this study was to elucidate the relationship between gastrointestinal motility and gastrointestinal symptoms in chronic kidney disease. We performed studies in C57BL/6 mice with chronic kidney disease after 5/6 nephrectomy. Gastrointestinal motility was evaluated by assessing the ex vivo responses of ileum and distal colon strips to electrical field stimulation. Feces were collected from mice, and the composition of the gut microbiota was analyzed using 16S ribosomal RNA sequencing...
October 14, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/30304311/evaluation-of-body-image-quality-of-life-tactile-sensitivity-and-pain-in-women-with-breast-cancer-submitted-to-surgical-intervention
#12
Juliana Nishimura Bueno, Cinira Assad Simão Haddad, Samantha Karlla Lopes De Almeida Rizzi, Patricia Santolia Giron, Gil Facina, Afonso Celso Pinto Nazário
OBJECTIVE: Breast cancer is one of the most common types of tumor in the world and the most common among women. There are several treatments for breast cancer; however, the condition often can be accompanied by severe complications in a woman's life. To evaluate and compare body image perception, quality of life, tenderness, and pain in women with breast cancer during preoperative and postoperative periods of 30, 60 and 90 days. MATERIALS AND METHODS: We conducted a prospective longitudinal study...
June 2018: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/30302125/uk-clinical-experience-up-to-52-weeks-with-linaclotide-for-irritable-bowel-syndrome-with-constipation
#13
Yan Yiannakou, Anu Agrawal, Patrick B Allen, Naila Arebi, Steven R Brown, Maria P Eugenicos, Adam D Farmer, Su McLain-Smith, John McLaughlin, David S Sanders, Dominic Lawrance, Anton Emmanuel
Background: Linaclotide, a guanylate cyclase C agonist, has been shown in clinical trials to improve symptoms of irritable bowel syndrome with constipation (IBS-C). Here we report data from a real-world study of linaclotide in the UK. Methods: This 1-year, multicentre, prospective, observational study in the UK enrolled patients aged 18 years and over initiating linaclotide for IBS-C. The primary assessment was change from baseline in IBS Symptom Severity Scale (IBS-SSS) score at 12 weeks, assessed in patients with paired baseline and 12-week data...
2018: Therapeutic Advances in Gastroenterology
https://www.readbyqxmd.com/read/30301605/functional-constipation-in-children-is-there-a-place-for-surgical-treatment
#14
Michael D Levin
No abstract text is available yet for this article.
September 30, 2018: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/30301467/infant-progressive-colonic-stenosis-caused-by-antibiotic-related-clostridium-difficile-colitis-a-case-report-and-literature-review
#15
Xiaolong Xie, Bo Xiang, Yang Wu, Yiyang Zhao, Qi Wang, Xiaoping Jiang
BACKGROUND: Colonic stenosis is a rare cause of pediatric intestinal obstruction. The root cause underlying colonic stenosis is unclear and there is no fixed operation. CASE PRESENTATION: We reported on a male infant with progressive colonic stenosis caused by antibiotic-related colitis. The infant was admitted to our hospital with pneumonia but developed progressive abdominal distension and diarrhea following antibiotic treatment with meropenem. Initial testing of stool culture showed a Clostridium difficile infection...
October 9, 2018: BMC Pediatrics
https://www.readbyqxmd.com/read/30301200/engineering-of-an-anti-inflammatory-peptide-based-on-the-disulfide-rich-linaclotide-scaffold
#16
Claudia Cobos, Paramjit S Bansal, Linda Jones, Phurpa Wangchuk, David Wilson, Alex Loukas, Norelle L Daly
Inflammatory bowel diseases are a set of complex and debilitating diseases, for which there is no satisfactory treatment. Peptides as small as three amino acids have been shown to have anti-inflammatory activity in mouse models of colitis, but they are likely to be unstable, limiting their development as drug leads. Here, we have grafted a tripeptide from the annexin A1 protein into linaclotide, a 14-amino-acid peptide with three disulfide bonds, which is currently in clinical use for patients with chronic constipation or irritable bowel syndrome...
October 6, 2018: Biomedicines
https://www.readbyqxmd.com/read/30297131/colon-constipation-in-horses-after-sustained-release-buprenorphine-administration
#17
Olivier L Levionnois, Claudia Graubner, Claudia Spadavecchia
OBJECTIVE: To investigate the pharmacological profile and side effects of buprenorphine administered as a sustained-release formulation in horses. STUDY DESIGN: Pilot trial. ANIMALS: A total of four experimental horses, aged 18-27 years and weighing 508-578 kg. METHODS: Buprenorphine (0.1 mg kg-1 ) was mixed as a freshly prepared sterile solution with a sustained-release drug carrier. It was administered by the subcutaneous (n = 2) or intramuscular (n = 2) route...
September 11, 2018: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/30294999/tips-for-managing-treatment-resistant-enuresis
#18
Patrina Hy Caldwell
Enuresis (bedwetting) is common in school-aged children and can impact health, psychosocial well-being and quality of life. Although effective treatment is available, treatment resistance is encountered in about 50%. This paper discusses the management of treatment-resistant enuresis from a multidisciplinary perspective. Causes of treatment resistance include lower urinary tract problems, constipation, incorrect alarm training techniques, sleep disorders including sleep apnoea and psychological comorbidities...
October 2018: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/30294989/children-who-soil-a-review-of-the-assessment-and-management-of-faecal-incontinence
#19
REVIEW
Misel Trajanovska, Sebastian K King, Susan Gibb, Sharon Goldfeld
Soiling is a common and distressing condition affecting children. In the vast majority of patients, it is associated with constipation. Most constipation is functional and is best thought of as difficulty achieving adequate bowel emptying. In a small minority of patients, there is no associated constipation, so-called non-retentive faecal incontinence. The aetiology of this latter condition in children remains unclear. The mainstay of management in all cases is a regular toileting programme, together with laxatives as required...
October 2018: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/30294848/use-of-gastrografin-in-the-management-of-faecal-impaction-in-patients-with-severe-chronic-constipation-a-randomized-clinical-trial
#20
Lili Gu, Chao Ding, Hongliang Tian, Bo Yang, Xuelei Zhang, Yue Hua, Jianfeng Gong, Ning Li
BACKGROUND/AIM: Faecal impaction (FI) is a common cause of lower gastrointestinal tract obstruction. Gastrografin is a water-soluble radiologic contrast agent that may be orally or rectally administered, with proved therapeutic benefits in adhesive small bowel obstruction. Enemas have long been advocated as the best treatment for FI. The purpose of this study was to demonstrate that enteral administration of gastrografin might be more effective than enema in FI treatment inducing intestinal obstruction...
October 8, 2018: ANZ Journal of Surgery
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