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constipation treatment

Chung-Wah Cheng, Li Zhang, Chen Zhao, Linda Ld Zhong, Li-Jie Shi, Liang Dai, Rui Zheng, Jing Chen, Ge Li, Jing-Bo Zhai, Wai Kun, Ai-Ping Lu, Hong-Cai Shang, Zhao-Xiang Bian
BACKGROUND: Syndrome is one of the most important concepts in Chinese medicine (CM) theory. However, it was not well accounted in most of randomized controlled trials (RCTs). OBJECTIVE: To determine whether CM syndrome differentiation affects the treatment results, functional constipation (FC) was selected as a target disease, and MaZiRenWan (, MZRW), a classic CM formula commonly used for constipation with excessive heat syndrome, was selected for study. METHODS: It is an 18-week prospective double-blinded, doubledummy RCT, including 2-week run-in, 8-week treatment and 8-week post treatment follow-up...
August 14, 2018: Chinese Journal of Integrative Medicine
Katherine R Bellesheim, Lynn Cole, Daniel L Coury, Larry Yin, Susan E Levy, Meghan A Guinnee, Kirsten Klatka, Beth A Malow, Terry Katz, Jane Taylor, Kristin Sohl
OBJECTIVES: Constipation and insomnia are not consistently identified and treated in children with autism spectrum disorder (ASD) despite their high prevalence and deleterious impact in this population. To standardize care, a constipation practice pathway and an insomnia practice pathway were previously developed by Autism Treatment Network clinicians. Our objective was to implement and refine these practice pathways in clinical settings. METHODS: Eleven Autism Treatment Network sites participated in a Learning Collaborative (ie, multidisciplinary quality improvement team) and chose to implement either the constipation or insomnia practice pathway in the clinical setting...
August 14, 2018: Pediatrics
Yuji Uchio, Hiroyuki Enomoto, Mitsuhiro Ishida, Toshinaga Tsuji, Toshimitsu Ochiai, Shinichi Konno
Purpose: To assess long-term safety, tolerability, and efficacy of duloxetine in Japanese patients with chronic knee pain due to osteoarthritis. Methods: In this open-label extension study (NCT02335346), Japanese patients with knee osteoarthritis and pain (Brief Pain Inventory [BPI] - Severity average pain score ≥4 at start of randomized trial) who had previously received duloxetine 60 mg/day or placebo for 14 weeks in a double-blind randomized trial entered the extension and received duloxetine 60 mg/day for 48 weeks...
2018: Journal of Pain Research
Rabia Miray Kisla Ekinci, Sibel Balcı, Okkes Ozgur Mart, Gokhan Tumgor, Sibel Yavuz, Halil Celik, Dilek Dogruel, Derya Ufuk Altintas, Mustafa Yilmaz
Henoch-Schönlein purpura (HSP), the most common childhood vasculitis is characterized by non-thrombocytopenic palpable purpura, arthritis/arthralgia, abdominal pain and renal involvement. Functional gastrointestinal disorders (FGIDs) are heterogeneous disease spectrum with unclear etiology and include the most common subtypes: functional dyspepsia, irritable bowel syndrome (IBS), functional abdominal pain and functional constipation. Formerly, FGIDs were known as non-organic disorders; however, recent advances revealed that low-grade inflammation may also play a role...
August 12, 2018: Rheumatology International
Jean-Frederic Colombel, Andrea Shin, Peter R Gibson
DESCRIPTION: The purpose of this clinical practice update review is to describe key principles in the diagnosis and management of functional gastrointestinal (GI) symptoms in patients with inflammatory bowel disease (IBD). METHODS: The evidence and best practices summarized in this manuscript are based on relevant scientific publications, systematic reviews, and expert opinion where applicable. BEST PRACTICE ADVICE 1: A stepwise approach to rule-out ongoing inflammatory activity should be followed in IBD patients with persistent GI symptoms (measurement of fecal calprotectin, endoscopy with biopsy, cross-sectional imaging)...
August 9, 2018: Clinical Gastroenterology and Hepatology
H C Melissant, F Jansen, L E R Schutte, B I Lissenberg-Witte, J Buter, C R Leemans, M A Sprangers, M R Vergeer, E T M Laan, I M Verdonck-de Leeuw
INTRODUCTION: The aim of this prospective study was to investigate the course of sexual interest and enjoyment in relation to sociodemographic and clinical factors, health-related quality of life (HRQOL), and symptoms of psychological distress in head and neck cancer (HNC) patients treated with primary (chemo)radiotherapy. METHODS: HNC patients (n = 354) completed patient-reported outcome measures (PROMs) on HRQOL (EORTC QLQ-C30 and QLQ-H&N35, including the sexuality subscale covering less sexual interest and enjoyment), and psychological distress (HADS) pretreatment, at 6-week follow-up and at 3-, 6-, 12-, 18-, and 24-month follow-up (i...
August 2018: Oral Oncology
Yun Liu, Brian Tomlinson, Jiyuan Guo, Mahnaz Asgharnejad, Lars Bauer, Erwin Surmann, Xiaojuan Guo, Jan-Peer Elshoff
PURPOSE: The pharmacokinetic (PK) profile of the rotigotine transdermal patch is well characterized in Caucasian patients with Parkinson's disease (PD) but not in Chinese subjects. This article reports the PK variables, safety, and tolerability of the rotigotine transdermal patch (2 mg/24 hours and 4 mg/24 hours cold-chain PR2.1.1 formulation) in healthy Chinese subjects (SP0913; NCT01675024). A second study (PD0011; NCT02070796) evaluated the relative bioavailability of cold-chain (PR2...
July 2018: Clinical Therapeutics
Teruko Nakamura, Taisei Fujisaki, Motoaki Miyazono, Maki Yoshihara, Hiroshi Jinnouchi, Kenichi Fukunari, Yuki Awanami, Yuki Ikeda, Kohei Hashimoto, Masatora Yamasaki, Yasunori Nonaka, Makoto Fukuda, Tomoya Kishi, Yuji Ikeda
BACKGROUND: Concerns about sodium overload when using sodium polystyrene sulfonate (Na-resin) as an ion-exchange resin for the treatment of hyperkalemia led our institution to gradually shift to the use of calcium polystyrene sulfonate (Ca-resin). However, as serum potassium levels were insufficiently controlled and patients experienced constipation, we returned to using Na-resin and observed better results than previously. OBJECTIVE: As few papers have examined the potassium adsorption ability of Ca-resin compared with Na-resin, we investigated this issue within our institution...
August 10, 2018: Drugs in R&D
Niresh Thapa, Muna Maharjan, Yan Xiong, Daqiong Jiang, Thi-Phuong Nguyen, Marcia A Petrini, Hongbing Cai
We aimed to assess the quality of life (QOL) of the patients with cervical cancer after initial treatment, the factors affecting QOL and their clinical relevance. A total of 256 patients with cervical cancer who visited Zhongnan Hospital of Wuhan University from January 2017 to December 2017 were enrolled in this study. The European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core-30 item (EORTC QLQ-C30) and cervical cancer module (EORTC QLQ-CX24) was used to assess the QOL of patients...
August 10, 2018: Scientific Reports
Tae-Hun Kim, Jung Won Kang, Myeong Soo Lee
BACKGROUND: Breast cancer survivors experience various symptoms associated with their cancer interventions, and the benefits of acupuncture for these symptoms have been evaluated in clinical trials worldwide. The purpose of this review was to discuss the current status of clinical research regarding the use of acupuncture as a part of traditional Korean medicine (KM) for various symptoms associated with breast cancer therapies. METHODS: We conducted a systematic review of the literature regarding the use of acupuncture as a part of traditional KM to treat symptoms associated with breast cancer therapies...
August 2018: Medicine (Baltimore)
Jean-Marie Freymond, Roland Chautems, Vincent Della Santa, Line Wolter
Hemorrhoids affect up to 85 % of pregnant women during the last two trimesters. The maximum incidence for anal fissure is 20 %. One of the common risk factors is constipation promoted during pregnancy. The history of anal pathology, the length of delivery and the baby's birth weight also promote these two entities. The treatment includes above all hygiene and dietary measures to prevent constipation and conservative measures (local anesthetics, sitz baths). Surgical procedures should be avoided and indicated only in case of failure of conservative treatment...
August 8, 2018: Revue Médicale Suisse
Eu Gene Park, Jiwon Lee, Jeehun Lee
Background and Purpose: The modified Atkins diet is a less restrictive alternative to the ketogenic diet (KD), allowing unlimited protein, fat, calories, and fluid intake. Moreover, it can be started on an outpatient basis without requiring a fast. This study evaluated the efficacy, tolerability, and compliance of the modified Atkins diet in intractable pediatric epilepsy. Methods: We retrospectively reviewed the medical records of 26 pediatric patients (10 males and 16 females) with intractable epilepsy who were treated using the modified Atkins diet at Samsung Medical Center from January 2011 to March 2017...
June 2018: Journal of Epilepsy Research
Juan Sebastian Lasa, María Josefina Altamirano, Luis Florez Bracho, Silvina Paz, Ignacio Zubiaurre
BACKGROUND: Intestinal secretagogues have been tested for the treatment of chronic constipation and constipation-predominant irritable bowel syndrome. The class-effect of these type of drugs has not been studied. OBJECTIVE: To determine the efficacy and safety of intestinal secretagogues for the treatment of chronic constipation and constipation-predominant irritable bowel syndrome. METHODS: A computer-based search of papers from 1966 to September 2017 was performed...
August 6, 2018: Arquivos de Gastroenterologia
Shin Fukudo, Hiroto Miwa, Atsushi Nakajima, Yoshikazu Kinoshita, Masanori Kosako, Ayako Nakagawa, Hiraku Akiho, Kentaro Kuroishi, Jeffrey M Johnston, Mark Currie, Toshifumi Ohkusa
BACKGROUND: Based on the previous phase II/III studies of irritable bowel syndrome with constipation (IBS-C) in Japan that demonstrated the efficacy and safety of linaclotide 0.5 mg/d, we evaluated linaclotide at doses of 0.5 mg/d and lower in the treatment of Japanese patients with chronic constipation (CC). METHODS: This was a phase II randomized, double-blind, placebo-controlled, dose-finding study of linaclotide for Japanese patients with CC (n = 382, 64 men, 318 women, age 20-75)...
August 7, 2018: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
K C Lakshmaiah, Tamojit Chaudhuri, Govind K Babu, Dasappa Lokanatha, Linu Abraham Jacob, M C Suresh Babu, A H Rudresha, K N Lokesh, L K Rajeev
BACKGROUND: After failing oxaliplatin-based first-line chemotherapy (CT), approximately 4%-21% of patients with metastatic colorectal cancer (mCRC) respond to irinotecan-based second-line treatment. Earlier studies have demonstrated that arsenic trioxide (ATO) can significantly resensitize resistant colon cancer to 5-fluorouracil (5-FU) by downregulating thymidylate synthase (TS). We hypothesized that a combination of ATO with infusional 5-FU, leucovorin, and irinotecan (FOLFIRI) regimen in mCRC patients refractory to first-line FOLFOX/CAPOX could further improve the outcome of second-line CT...
October 2017: Indian Journal of Cancer
Yu Zhang, Ziqing Li, Fan Han
BACKGROUND: Irritable bowel syndrome (IBS) is a common functional intestinal disease characterized by chronic or recurrent abdominal pain, abdominal distension, constipation and diarrhea. Many IBS sufferers are usually present with poor quality of life for the abdominal discomfort, diarrhea, constipation, and other complaints. At present, the commonly used drug therapy for IBS in the Western clinic, such as antidiarrheal, laxative, gastrointestinal antispasmodic, often cannot get satisfying curative effect...
August 2018: Medicine (Baltimore)
Xianghai Ren, Hui Xiao, Long Li, Mei Diao, Long Chen, Ruijie Zhou, Haibo Li, Xu Li, Wei Cheng
PURPOSE: The aim of this study was to compare the safety and efficacy of single-incision laparoscopic-assisted anorectoplasty (SILAARP) to that of traditional three-port laparoscopic-assisted anorectoplasty (3-PLAARP) for persistent cloaca (PC) patients with mid to high rectal pouches in midterm follow-up. MATERIALS AND METHODS: A study comparing 13 SILAARPs and 12 3-PLAARPs performed by a single surgeon from November 2005 to May 2016 was presented (laparoscopy was performed for anorectoplasty, and urethra vaginoplasty was performed perineally)...
August 3, 2018: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
Jojanneke J G T van Summeren, Gea A Holtman, Yvonne Lisman-van Leeuwen, Lisa E A M Louer, Alice H C van Ulsen-Rust, Karin M Vermeulen, Boudewijn J Kollen, Janny H Dekker, Marjolein Y Berger
BACKGROUND: Our aim was to design a study to evaluate the effectiveness and cost-effectiveness of adding physiotherapy to conventional treatment for children with functional constipation in primary care. Physiotherapy is focusing on improving the coordination between the pelvic floor and abdominal musculature during bowel movement, while conventional treatment is mainly focusing on symptomatic relief of symptoms, therefore, we expect the effects of physiotherapy will be more sustainable than the effects of conventional treatment...
July 31, 2018: BMC Pediatrics
G Major, K Murray, G Singh, A Nowak, C L Hoad, L Marciani, A Silos-Santiago, C B Kurtz, J M Johnston, P Gowland, R Spiller
BACKGROUND: In functional gastrointestinal disorders a lack of objective biomarkers limits evaluation of underlying mechanisms. We aimed to demonstrate the utility of magnetic resonance imaging for this task using psyllium, an effective constipation treatment, in patients and controls. METHODS: Two crossover studies: (i) adults without constipation (controls, n = 9) took three treatments in randomized order for 6 days - maltodextrin (placebo), psyllium 3.5 g t...
July 30, 2018: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
Agnieszka Pastuszka, Janusz Bohosiewicz, Tomasz Koszutski
AIMS: The aim of the study was to evaluate the lower urinary tract function, frequency UTI, the degree of social urine continence, and the occurrence of constipation in children who underwent prenatal or postnatal surgery for MMC. MATERIALS AND METHODS: Seventy-two patients with MMC were assessed and divided into the prenatal group (36 patients) and the postnatal one (36 patients). All children, regardless the time of operation, received the same treatment after birth...
July 30, 2018: Neurourology and Urodynamics
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