Marc Fischer, Thomas Küstner, Sofia Pappa, Thoralf Niendorf, Tobias Pischon, Thomas Kröncke, Stefanie Bette, Sara Schramm, Börge Schmidt, Johannes Haubold, Felix Nensa, Tobias Nonnenmacher, Viktoria Palm, Fabian Bamberg, Lena Kiefer, Fritz Schick, Bin Yang
In this work, we propose a processing pipeline for the extraction and identification of meaningful radiomics biomarkers in skeletal muscle tissue as displayed using Dixon-weighted MRI. Diverse and robust radiomics features can be identified that may be of aid in the accurate quantification e.g. varying degrees of sarcopenia in respective muscles of large cohorts. As such, the approach comprises the texture feature extraction from raw data based on well established approaches, such as a nnU-Net neural network and the Pyradiomics toolbox, a subsequent selection according to adequate conditions for the muscle tissue of the general population, and an importance-based ranking to further narrow the amount of meaningful features with respect to auxiliary targets...
August 8, 2023: BMC Medical Imaging