Matilda A Haas, Linh Ngo, Shan Shan Li, Sibylle Schleich, Zhengdong Qu, Hannah K Vanyai, Hayley D Cullen, Aida Cardona-Alberich, Ivan E Gladwyn-Ng, Alistair T Pagnamenta, Jenny C Taylor, Helen Stewart, Usha Kini, Kent E Duncan, Aurelio A Teleman, David A Keays, Julian I-T Heng
Disruptions to neuronal mRNA translation are hypothesized to underlie human neurodevelopmental syndromes. Notably, the mRNA translation re-initiation factor DENR is a regulator of eukaryotic translation and cell growth, but its mammalian functions are unknown. Here, we report that Denr influences the migration of murine cerebral cortical neurons in vivo with its binding partner Mcts1, whereas perturbations to Denr impair the long-term positioning, dendritic arborization, and dendritic spine characteristics of postnatal projection neurons...
June 7, 2016: Cell Reports