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https://www.readbyqxmd.com/read/30545313/ultrasound-point-shear-wave-elastography-of-the-pancreas-comparison-of-patients-with-type-1-diabetes-and-healthy-volunteers-results-from-a-pilot-study
#1
Sophie Püttmann, Janina Koch, Jochen Paul Steinacker, Stefan Andreas Schmidt, Thomas Seufferlein, Wolfgang Kratzer, Julian Schmidberger, Burkhard Manfras
BACKGROUND: The aims of this study were to establish shear wave elastography of the pancreas by comparing measurements in patients with type 1 diabetes (T1D) and healthy volunteers and to consider whether this method could contribute to the screening or prevention of T1D. METHODS: This pilot study included 15 patients with T1D (10 men, 5 women) and 15 healthy volunteers (10 men, 5 women) as controls. Measurements were performed with a Siemens Acuson S3000 (Siemens Healthcare, Erlangen, Germany) using a 6C1 convex transducer and the Virtual Touch™ tissue quantification (VTQ) method...
December 13, 2018: BMC Medical Imaging
https://www.readbyqxmd.com/read/30543021/efficacy-and-safety-of-massage-for-osteoarthritis-of-the-knee-a-randomized-clinical-trial
#2
Adam Perlman, Susan Gould Fogerite, Oliver Glass, Elizabeth Bechard, Ather Ali, Valentine Y Njike, Carl Pieper, Natalia O Dmitrieva, Alison Luciano, Lisa Rosenberger, Teresa Keever, Carl Milak, Eric A Finkelstein, Gwendolyn Mahon, Giovanni Campanile, Ann Cotter, David L Katz
BACKGROUND: Current treatment options for knee osteoarthritis have limited effectiveness and potentially adverse side effects. Massage may offer a safe and effective complement to the management of knee osteoarthritis. OBJECTIVE: Examine effects of whole-body massage on knee osteoarthritis, compared to active control (light-touch) and usual care. DESIGN: Multisite RCT assessing the efficacy of massage compared to light-touch and usual care in adults with knee osteoarthritis, with assessments at baseline and weeks 8, 16, 24, 36, and 52...
December 12, 2018: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/30521851/genetic-inactivation-of-hypoxia-inducible-factor-1-alpha-hif-1%C3%AE-in-adult-hippocampal-progenitors-impairs-neurogenesis-and-pattern-discrimination-learning
#3
Lauren Carrica, Lu Li, Jessie Newville, Johnny Kenton, Kymberly Gustus, Jonathan Brigman, Lee Anna Cunningham
HIF-1α is a hypoxia-inducible protein that regulates many cellular processes, including neural stem cell maintenance. Previous work demonstrated constitutive stabilization of HIF-1α in neural stem cells (NSCs) of the adult mouse subventricular zone (SVZ) and hippocampal subgranular zone (SGZ). Genetic inactivation of NSC-encoded HIF-1α in the adult SVZ results in gradual loss of NSCs, but whether HIF-1α is required for the maintenance of SGZ hippocampal progenitors and adult hippocampal neurogenesis has not been determined...
December 3, 2018: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/30511843/an-open-source-plate-reader
#4
Karol P Szymula, Michael S Magaraci, Michael Patterson, Andrew Clark, Sevile G Mannickarottu, Brian Y Chow
Microplate readers are foundational instruments in ex-perimental biology and bioengineering that enable mul-tiplexed spectrophotometric measurements. To enhance their accessibility, we here report the design, construc-tion, validation, and benchmarking of an open-source microplate reader. The system features full-spectrum absorbance and fluorescence emission detection, in situ optogenetic stimulation, and stand-alone touch screen programming of automated assay protocols. The total system costs <$3500, a fraction of the cost of commer-cial plate readers, and can detect the fluorescence of common dyes down to ~10 nanomolar concentration...
December 4, 2018: Biochemistry
https://www.readbyqxmd.com/read/30487772/effect-of-age-and-dietary-intervention-on-discrimination-learning-in-pet-dogs
#5
Durga Chapagain, Zsófia Virányi, Ludwig Huber, Jessica Serra, Julia Schoesswender, Friederike Range
Aging is associated with a decline in cognitive functions such as learning, memory, attention, cognitive flexibility, and executive functions. Recent evidence indicates that interventions such as exercise, diet and cognitive training can be used to reduce the rate of age-dependent cognitive decline. In this study, we examined the changes in discrimination learning in older pet dogs, tested whether a dietary intervention counteracts a potential decline in learning and evaluated the influence of lifelong training on learning speed and cognitive flexibility...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/30485317/exploring-attentional-bias-towards-threatening-faces-in-chimpanzees-using-the-dot-probe-task
#6
Duncan A Wilson, Masaki Tomonaga
Primates have evolved to rapidly detect and respond to danger in their environment. However, the mechanisms involved in attending to threatening stimuli are not fully understood. The dot-probe task is one of the most widely used experimental paradigms to investigate these mechanisms in humans. However, to date, few studies have been conducted in non-human primates. The aim of this study was to investigate whether the dot-probe task can measure attentional biases towards threatening faces in chimpanzees. Eight adult chimpanzees participated in a series of touch screen dot-probe tasks...
2018: PloS One
https://www.readbyqxmd.com/read/30485289/basic-color-categories-and-mandarin-chinese-color-terms
#7
Vincent C Sun, Chien-Chung Chen
Basic color terms used in Mandarin Chinese have been controversial since first discussed by Berlin and Kay in 1969. Previous studies showed much inconsistency on what should be considered as basic color terms in Mandarin Chinese. In the present study, we investigated categories of color rather than merely the color terms used by Taiwanese native Mandarin speakers. Using samples conforming to the Berlin and Kay survey, various colors were chosen from a collection of Natural Color System (NCS) colored papers and mounted on a piece of neutral gray card...
2018: PloS One
https://www.readbyqxmd.com/read/30475010/slow-and-steady-training-induced-improvements-to-response-time-consistency-are-due-to-overall-slowing-and-minimized-extremely-slow-responses
#8
Brandon P Vasquez, Nicole D Anderson
Previous studies on response time intraindividual variability (RT IIV) have focused on differences between groups, ignoring the potential for modification. The current study provides a detailed analysis of RT IIV training effects across three age groups. Healthy adults (40 young [aged 18-30], 40 young-old [aged 65-74], and 41 old-old [aged 75-85]) were assigned to feedback or no feedback (standard) conditions during a touch-screen feature integration task. In the feedback condition, participants were shown their performance on the previous block of trials and encouraged to improve going forward...
November 26, 2018: Psychology and Aging
https://www.readbyqxmd.com/read/30474783/feasibility-of-a-novel-technique-using-3-dimensional-modeling-and-augmented-reality-for-access-during-percutaneous-nephrolithotomy-in-two-different-ex-vivo-models
#9
Murat Akand, Levent Civcik, Ahmet Buyukaslan, Emre Altintas, Erdinc Kocer, Mustafa Koplay, Tibet Erdogru
PURPOSE: We describe a novel technique that uses mathematical calculation software, 3-dimensional (3D) modeling and augmented reality (AR) technology for access during percutaneous nephrolithotomy (PCNL) and report our first preliminary results in two different ex-vivo models. METHODS: Novel software was created in order to calculate access point and angle by using pre-operative computed tomography (CT) obtained in 50 patients. Two scans, 27 s and 10 min after injection of contrast agent, were taken in prone PCNL position...
November 24, 2018: International Urology and Nephrology
https://www.readbyqxmd.com/read/30468150/theory-for-the-negative-longitudinal-magnetoresistance-in-the-quantum-limit-of-kramers-weyl-semimetals
#10
Bo Wan, Frank Schindler, Ke Wang, Kai Wu, Xiangang Wan, Titus Neupert, Hai-Zhou Lu
Negative magnetoresistance is rare in non-magnetic materials. Recently, negative magnetoresistance has been observed in the quantum limit of β-Ag2 Se, where only one band of Landau levels is occupied in a strong magnetic field parallel to the applied current. β-Ag2 Se is a material that hosts a Kramers Weyl cone with band degeneracy near the Fermi energy. Kramers Weyl cones exist at time-reversal invariant momenta in all symmorphic chiral crystals, and at a subset of these momenta, including the Γ point, in non-symmorphic chiral crystals...
November 23, 2018: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/30462076/fast-numerical-fourier-analysis-of-moir%C3%A3-pattern-induced-by-a-periodic-metallic-array-on-top-of-the-microscopically-patterned-red-green-blue-light-sources
#11
M Pournoury, A Zamiri, T Y Kim, V Yurlov, K Oh
An accurate and fast moiré pattern analysis algorithm is proposed for a periodic metallic array placed adjacent to a patterned red-green-blue (RGB) light source with a microscopic gap utilizing Fourier transform along with the human eye contrast sensitivity function. We analyzed how the moiré pattern evolved varying tilt angles and metal array periodicities placed on the top of RGB light sources, which have their own spatial periodicities. Based on multiplicative model, moiré patterns were numerically generated and the influences of 70 tilt angles and 60 periodicities on the moiré standard deviation were thoroughly analyzed to minimize moiré visibility...
September 20, 2018: Applied Optics
https://www.readbyqxmd.com/read/30461290/prevalence-of-diabetic-neuropathy-in-young-adults-with-type-1-diabetes-and-the-association-with-insulin-pump-therapy
#12
Marie Mathilde Bjerg Christensen, Eva Elisabeth Hommel, Marit Eika Jørgensen, Bernt Johan von Scholten, Jesper Fleischer, Christian Stevns Hansen
AIMS: The aim was to investigate the prevalence of diabetic sensorimotor polyneuropathy (DSPN) and cardiovascular autonomic neuropathy (CAN) in a Danish population of young adults with type 1 diabetes (T1D) using both established and novel measuring modalities. Furthermore, to investigate the association between continuous subcutaneous insulin infusion (CSII) treatment and these complications. MATERIALS AND METHODS: CAN was assessed by cardiovascular autonomic reflex tests...
November 21, 2018: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/30444168/comparing-patient-reported-outcomes-entered-at-home-versus-at-hospital-and-testing-touch-screens-for-initial-recruitment-to-scientific-trials-in-arthritis-patients
#13
A E Secher, B Glintborg, H Gudbergsen, N S Krogh, I J Sørensen, D V Jensen, R Christensen, M Skougaard, P L Pedersen, M L Hetland
OBJECTIVES: Touch screens for entering patient-reported outcomes (PROs) are available at all Danish departments of rheumatology reporting to the nationwide DANBIO registry. This project comprises two substudies in patients with rheumatoid arthritis (RA) or axial spondyloarthritis (AxSpA), aiming to (A) investigate the feasibility of first line patient recruitment for research via touch screens, and (B) compare PROs collected at hospital versus at home, including patient preferences. METHOD: Substudy A: using a touch screen, patients answered whether we could contact them about a clinical research project (yes/no)...
November 16, 2018: Scandinavian Journal of Rheumatology
https://www.readbyqxmd.com/read/30441102/a-gaze-based-virtual-keyboard-using-a-mouth-switch-for-command-selection
#14
S Soundarajan, H Cecotti
Portable eye-trackers provide an efficient way to access the point of gaze from a user on a computer screen. Thanks to eyetracking, gaze-based virtual keyboard can be developed by taking into account constraints related to the gaze detection accuracy. In this paper, we propose a new gaze-based virtual keyboard where all the letters can be accessed directly through a single command. In addition, we propose a USB mouth switch that is directly connected through a computer mouse, with the mouse switch replacing the left click button...
July 2018: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/30440300/design-and-evaluation-of-a-portable-smart-phone-based-peripheral-neuropathy-test-platform
#15
Peter G Jacobs, Peter Hanaway, Joseph Leitschuh, John Condon, Uma Rajhbeharrysingh, Clara Mosquera-Lopez, Carolyn Guidarelli, Kerri Winters-Stone
In this paper, we describe a novel portable test platform that can be used to test peripheral neuropathy either within a clinic or at home. The system, called the PeriVib, is comprised of (1) a small, custom vibration motor designed to apply a vibration stimulus to the toe with constant pressure to test sensation threshold, and (2) a custom smart-phone app that enables a patient to run a series of functional gait and balance tests. Vibration is applied by PeriVib in two separate modes. The first mode, ramp-up, starts at zero amplitude and increases to a maximum level while the patient indicates when they start feeling the pressure by lifting their finger off the touch-screen on the phone...
July 2018: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/30423105/protein-pocket-detection-via-convex-hull-surface-evolution-and-associated-reeb-graph
#16
Rundong Zhao, Zixuan Cang, Yiying Tong, Guo-Wei Wei
Motivation: Protein pocket information is invaluable for drug target identification, agonist design, virtual screening and receptor-ligand binding analysis. A recent study indicates that about half holoproteins can simultaneously bind multiple interacting ligands in a large pocket containing structured sub-pockets. Although this hierarchical pocket and sub-pocket structure has a significant impact to multi-ligand synergistic interactions in the protein binding site, there is no method available for this analysis...
September 1, 2018: Bioinformatics
https://www.readbyqxmd.com/read/30418301/differences-in-performance-on-developmental-tasks-in-young-children-across-digital-and-paper-based-modalities-a-feasibility-trial
#17
Allison G Dempsey, Amy K Barton, Andrea F Duncan
OBJECTIVE: To determine whether use of digital-based screening is a feasible approach to monitoring child development, it is necessary to assess young children's abilities to interface with touch screen technology. The primary objectives of this exploratory feasibility study with a randomized experimental design were to determine (1) whether young children respond differently to developmental tasks on paper versus tablet device and (2) whether responses to items presented digitally differed according to hours of weekly exposure to touch screen technology in the home...
November 9, 2018: Journal of Developmental and Behavioral Pediatrics: JDBP
https://www.readbyqxmd.com/read/30391909/key-periods-of-cognitive-decline-in-a-nonhuman-primate-model-of-cognitive-aging-the-common-marmoset-callithrix-jacchus
#18
Amirouche Sadoun, Maxime Rosito, Caroline Fonta, Pascal Girard
It is well established that human life expectancy increases considerably with an ever-growing number of people suffering from age-related cognitive decline and degenerative brain diseases. This necessitates the development of animal models to counteract or stop the progression of the decline early enough. Presently, primate models are few, and many studies argue for the marmoset as an interesting primate model presenting a short life span and being easily available in research laboratories. In this article, we propose the marmoset as a valid model for cognitive decline...
October 11, 2018: Neurobiology of Aging
https://www.readbyqxmd.com/read/30386266/impulsive-action-and-impulsive-choice-are-differentially-expressed-in-rats-depending-on-the-age-at-exposure-to-a-gambling-task
#19
Bo Ram Cho, Myung Ji Kwak, Wha Young Kim, Jeong-Hoon Kim
Impulsivity is considered an important feature associated with the development of numerous psychiatric disorders, including addictions. In the behavioral approach, impulsivity can be broadly divided into two distinct subtypes: impulsive action and choice. In the present study, we used a rodent version of the gambling task (rGT) to examine how impulsive action and impulsive choice are differentially influenced by difference in age at exposure (i.e., late adolescents/young adults vs. mature adults) to rGT. Rats were trained in a touch-screen chamber to learn the relationships between 4 light signals on the window of the screen and accompanying reward outcomes or punishments associated with different magnitudes and probabilities...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/30380974/development-of-a-touch-down-multiplex-pcr-method-for-simultaneously-rapidly-detecting-three-novel-insertion-deletions-indels-within-one-gene-an-example-for-goat-ghr-gene
#20
Qing Yang, Shaoli Zhang, Jie Li, Xinyu Wang, Kun Peng, Xianyong Lan, Chuanying Pan
The multiplex polymerase chain reaction (PCR) method is fast and accuracy for screening several polymorphism loci in a single reaction in large samples. Therefore, this study aimed to identify three novel insertion/deletion (indel) loci in goat growth hormone receptor (GHR) gene by using multiplex PCR method and the genotypes in three indel loci are identified in 918 individuals from three Chinese goat breeds, as well as to evaluate its associations with growth traits. After validating the accuracy by taking the conventional PCR method, the concordance between these two methods was 100%...
October 31, 2018: Animal Biotechnology
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