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https://www.readbyqxmd.com/read/30333735/impaired-performance-of-the-q175-mouse-model-of-huntington-s-disease-in-the-touch-screen-paired-associates-learning-task
#1
Tuukka O Piiponniemi, Teija Parkkari, Taneli Heikkinen, Jukka Puoliväli, Larry C Park, Roger Cachope, Maksym V Kopanitsa
Cognitive disturbances often predate characteristic motor dysfunction in individuals with Huntington's disease (HD) and place an increasing burden on the HD patients and caregivers with the progression of the disorder. Therefore, application of maximally translational cognitive tests to animal models of HD is imperative for the development of treatments that could alleviate cognitive decline in human patients. Here, we examined the performance of the Q175 mouse knock-in model of HD in the touch screen version of the paired associates learning (PAL) task...
2018: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/30326151/differential-effects-of-d1-and-d2-dopamine-agonists-on-memory-motivation-learning-and-response-time-in-non-human-primates
#2
Robert A Marino, Ron Levy
Dopamine (DA) plays a critical role in cognition, motivation and information processing. DA action has been shown to both improve and/or impair cognition across different receptor types, species, subjects, and tasks. This complex relationship has been described as an inverted U-shaped function and may be due to the differential effects of DA receptor activation in the striatum and prefrontal cortex. We have investigated the effects of selective DA agonists on cognitive performance in healthy monkeys using a touch screen running tasks from the CAmbridge Neuropsychological Test Automated Battery (CANTAB)...
October 16, 2018: European Journal of Neuroscience
https://www.readbyqxmd.com/read/30325716/a-field-evaluation-of-a-single-sampler-for-respirable-and-inhalable-indium-and-dust-measurements-at-an-indium-tin-oxide-manufacturing-facility
#3
Brie Hawley, Jenna L Gibbs, Kristin Cummings, Aleksandr B Stefaniak, Ji Young Park, Marcia Stanton, M Abbas Virji
Indium-tin oxide production has increased greatly in the last twenty years subsequent to increased global demand for touch screens and photovoltaics. Previous studies used measurements of indium in blood as an indicator of indium exposure and observed associations with adverse respiratory outcomes. However, correlations between measurements of blood indium and airborne respirable indium are inconsistent, in part because of the long half-life of indium in blood, but also because respirable indium measurements do not incorporate inhalable indium that can contribute to the observed biological burden...
October 16, 2018: Journal of Occupational and Environmental Hygiene
https://www.readbyqxmd.com/read/30306809/a-tablet-based-program-to-enable-people-with-intellectual-and-other-disabilities-to-access-leisure-activities-and-video-calls
#4
Giulio E Lancioni, Nirbhay N Singh, Mark F O'Reilly, Jeff Sigafoos, Gloria Alberti, Viviana Perilli, Valeria Chiariello, Giovanna Grillo, Cosimo Turi
PURPOSE: This study evaluated a tablet-based program to help eight participants with moderate intellectual disability, sensory and/or motor impairments, and lack of expressive or expressive and receptive verbal skills to select and access leisure activities and video calls independently. METHODS: The program relied on the use of a tablet (i.e., Samsung Galaxy Tab S2 LTE) with 8-inch screen, Android 6.0 Operating System, front camera, proximity sensor and multimedia player...
October 11, 2018: Disability and Rehabilitation. Assistive Technology
https://www.readbyqxmd.com/read/30298715/characterization-of-mechanical-degradation-in-perfluoropolyether-film-for-its-application-to-anti-fingerprint-coatings
#5
Kyoungmin Min, Jungim Han, Byungha Park, Eunseog Cho
Enhancing the mechanical durability of anti-fingerprint films is critical for its industrial application on touch-screen devices to withstand friction damage from repeated rubbing in daily usage. Using reactive molecular dynamics simulations, we herein implement adhesion, mechanical, and deposition tests to investigate two durability-determining factors: intrachain and interchain strength, which affect the structural stability of the anti-fingerprint film (perfluoropolyether) on silica. From the intrachain perspective, it is found that the Si-C bond in the polymer chain is the weakest, and therefore prone to dissociation and potentially forming a C-O bond...
October 9, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/30280006/a-smartphone-based-tool-for-rapid-portable-and-automated-wide-field-retinal-imaging
#6
Tyson N Kim, Frank Myers, Clay Reber, P J Loury, Panagiota Loumou, Doug Webster, Chris Echanique, Patrick Li, Jose R Davila, Robi N Maamari, Neil A Switz, Jeremy Keenan, Maria A Woodward, Yannis M Paulus, Todd Margolis, Daniel A Fletcher
Purpose: High-quality, wide-field retinal imaging is a valuable method for screening preventable, vision-threatening diseases of the retina. Smartphone-based retinal cameras hold promise for increasing access to retinal imaging, but variable image quality and restricted field of view can limit their utility. We developed and clinically tested a smartphone-based system that addresses these challenges with automation-assisted imaging. Methods: The system was designed to improve smartphone retinal imaging by combining automated fixation guidance, photomontage, and multicolored illumination with optimized optics, user-tested ergonomics, and touch-screen interface...
September 2018: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/30279387/integration-of-a-2d-touch-sensor-with-an-electroluminescent-display-by-using-a-screen-printing-technology-on-textile-substrate
#7
Josue Ferri, Clara Perez Fuster, Raúl Llinares Llopis, Jorge Moreno, Eduardo Garcia-Breijo
Many types of solutions have been studied and developed in order to give the user feedback when using touchpads, buttons, or keyboards in textile industry. Their application on textiles could allow a wide range of applications in the field of medicine, sports or the automotive industry. In this work, we introduce a novel solution that combines a 2D touchpad with an electroluminescent display (ELD). This approach physically has two circuits over a flexible textile substrate using the screen-printing technique for wearable electronics applications...
October 2, 2018: Sensors
https://www.readbyqxmd.com/read/30275298/two-are-better-than-one-infant-language-learning-from-video-improves-in-the-presence-of-peers
#8
REVIEW
Sarah Roseberry Lytle, Adrian Garcia-Sierra, Patricia K Kuhl
Studies show that young children learn new phonemes and words from humans significantly better than from machines. However, it is not clear why learning from video is ineffective or what might be done to improve learning from a screen. The present study, conducted with 9-month-old infants, utilized a manipulation-touch screen video-which allowed infants to control presentations of foreign-language video clips. We tested the hypothesis that infant learning from a screen would be enhanced in the presence of a peer, as opposed to learning alone...
October 2, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/30273130/thunderpunch-a-bare-hand-gesture-based-large-interactive-display-interface-with-upper-body-part-detection-in-a-top-view
#9
Daehwan Kim, Hye-Mi Kim, Hang-Kee Kim, Su-Ran Park, Ki-Suk Lee, Ki-Hong Kim
We present a new bare-hand gesture interface for large-screen interaction in which multiple users can participate simultaneously and interact with virtual content directly. To better reflect the intent of our new interface, we have created a new type of hardware system with a large hybrid display, named ThunderPunch. Unlike the conventional method, which involves positioning the camera in front, the cameras are mounted on the ceiling so that they avoid covering the large screen. To achieve bare-hand interaction in this hardware structure, we propose real-time algorithms that detect multiple body poses and recognize punching and touching gestures from top-view depth images...
September 2018: IEEE Computer Graphics and Applications
https://www.readbyqxmd.com/read/30271134/development-and-assessment-of-a-web-based-intervention-for-educating-older-people-on-strategies-promoting-healthy-cognition
#10
Divya Vanoh, Intan Hafizah Ishak, Suzana Shahar, Zahara Abdul Manaf, Nazlena Mohamad Ali, Shahrul Azman Mohd Noah
Background: The increase in the population of aging people has increased the occurrence of cognitive decline leading to predemented stage of dementia, ie, mild cognitive impairment (MCI). The cognitive tools that are web-based have been proven to be useful in decreasing the risk of MCI. Thus, in the present study, an education tool that is web-based, called WESIHAT 2.0© , had been created to educate elderly people about precautionary strategies against MCI. Methodology: WESIHAT 2...
2018: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/30256769/a-dual-method-approach-to-identifying-intimate-partner-violence-within-a-level-1-trauma-center
#11
Susan DiVietro, Rebecca Beebe, Damion Grasso, Christa Green, D'Andrea Joseph, Garry D Lapidus
BACKGROUND: Intimate partner violence (IPV) is a serious public health problem leading many health care organizations to recommend universal screening as part of standard health care practice. Prior work shows that most IPV victims and perpetrators are unidentified by health care staff. We sought to enhance the capacity of an urban trauma center to identify IPV using a dual-method screening tool, and to establish prevalence of IPV victimization and perpetration among this population. METHODS: Patients aged 18 and older were recruited from a Level 1 trauma center from May 2015 to July 2017...
October 2018: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/30249318/evolution-of-a-pre-exposure-prophylaxis-prep-service-in-a-community-located-sexual-health-clinic-concise-report-of-the-prepxpress
#12
Nicolo Girometti, Sheena McCormack, Emma Devitt, Keerti Gedela, Nneka Nwokolo, Sheel Patel, Tara Suchak, Alan McOwan, Gary Whitlock
Screening and treatment of sexually transmissible infections, including HIV, are free in the UK nations; pre-exposure prophylaxis (PrEP) became free in England in October 2017 through the PrEP Impact trial. Doctor-led PrEP clinics started at 56 Dean Street in September 2015, with the drug purchased privately at full price. The service was expanded to other staff to support initiation and monitoring of increasing numbers of attendees purchasing PrEP from online pharmacies. Nonetheless, when the clinic was given a target of 1700 for the PrEP Impact trial, it was clear this could not be achieved in a timely manner through 56 Dean Street alone...
September 25, 2018: Sexual Health
https://www.readbyqxmd.com/read/30226754/flexible-and-highly-sensitive-resistive-pressure-sensor-based-on-carbonized-crepe-paper-with-corrugated-structure
#13
Sheng Chen, Yijia Song, Feng Xu
Recently, cellulose paper based materials have emerged for applications in wearable "green" electronics due to their earth abundance, low cost, light weight, flexibility, and sustainability. Herein, for the first time, we develop an almost all cellulose paper based pressure sensor through a facile, cost-effective, scalable, and environment-friendly approach. The screen-printed interdigital electrodes on the flat printing paper and the carbonized crepe paper (CCP) with good conductivity are integrated into a flexible pressure sensor as substrates and active materials, respectively...
October 10, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/30215711/bi-allelic-mutations-in-myl1-cause-a-severe-congenital-myopathy
#14
Gianina Ravenscroft, Irina Zaharieva, Carlo A Bortolotti, Matteo Lambrughi, Marcello Pignataro, Marco Borsari, Caroline A Sewry, Rahul Phadke, Goknur Haliloglu, Royston Ong, Hayley Goullée, Tamieka Whyte, Adnan Manzur, Beril Talim, Ulkuhan Kaya, Daniel Ps Osborn, Alistair Forrest, Nigel G Laing, Francesco Muntoni
OBJECTIVE: Congenital myopathies are typically characterised by early onset hypotonia, weakness and hallmark features on biopsy. Despite the rapid pace of gene discovery, approximately 50% of patients with a congenital myopathy remain without a genetic diagnosis following screening of known disease genes. METHODS: We performed exome sequencing on two consanguineous probands diagnosed with a congenital myopathy and muscle biopsy showing selective atrophy/hypotrophy or absence of type II myofibres...
September 12, 2018: Human Molecular Genetics
https://www.readbyqxmd.com/read/30197977/application-of-a-nanotechnology-based-point-of-care-diagnostic-device-in-diabetic-kidney-disease
#15
Vinay Kumar, Suraj Hebbar, Ananthram Bhat, Sachin Panwar, Madhumati Vaishnav, Kavitha Muniraj, Vasanthi Nath, Reshma Banaki Vijay, Sapna Manjunath, Babithadevi Thyagaraj, Chandraprabha Siddalingappa, Muralidharakrishna Chikkamoga Siddaiah, Indranil Dasgupta, Urmila Anandh, Thummala Kamala, S S Srikanta, P R Krishnaswamy, Navakanta Bhat
Introduction: Early detection of diabetes mellitus (DM) and diabetic kidney disease (DKD) is important for preventing end-stage renal failure and reducing cardiovascular complications. Availability of a validated point-of-care (PoC) device that can measure various DKD markers would be useful in this respect, especially in resource-poor parts of the world. Methods: We validated a novel nanotechnology-based multianalyte PoC device (minimally invasive and does not require trained medical personnel) against laboratory gold standard tests for the detection of 5 biomarkers related to management of DM and DKD...
September 2018: KI Reports
https://www.readbyqxmd.com/read/30195152/visualising-latent-dna-on-swabs
#16
P Kanokwongnuwut, P Kirkbride, A Linacre
Collection for touch DNA either at scenes or on items submitted to a forensic laboratory is based on assumptions as to where a person made direct contact. In many instances a swab may be applied to an area where no contact has been made. Many swabs may therefore be submitted for DNA profiling on which no DNA is present, resulting in the loss of both time and resources by analysing such swabs. This study has developed a simple, fast, DNA-staining and fluorescence microscopy-based screening method for swabs to indicate if there is any DNA from which to generate a profile...
August 25, 2018: Forensic Science International
https://www.readbyqxmd.com/read/30185636/camouflage-strategies-interfere-differently-with-observer-search-images
#17
Jolyon Troscianko, John Skelhorn, Martin Stevens
Numerous animals rely on camouflage for defence. Substantial past work has identified the presence of multiple strategies for concealment, and tested the mechanisms underpinning how they work. These include background matching, D-RUP coloration to destroy target edges, and distractive markings that may divert attention from key target features. Despite considerable progress, work has focused on how camouflage types prevent initial detection by naive observers. However, predators will often encounter multiple targets over time, providing the opportunity to learn or focus attention through search images...
September 5, 2018: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/30170509/reiki-for-pain-during-hemodialysis-a-feasibility-and-instrument-evaluation-study
#18
Savannah Zins, Mary Catherine Hooke, Cynthia R Gross
PURPOSE: Pain is a problem for individuals undergoing hemodialysis. Renal disease, comorbidities, concurrent symptoms, and dialysis procedures pose barriers to adequate pain management. The purpose of this study was to evaluate feasibility, examine construct validity of The Patient-Reported Outcomes Measurement Information System (PROMIS) computerized adaptive testing (CAT) instruments, and explore pain benefits of Reiki sessions conducted during hemodialysis. DESIGN: A one group, repeated-measures design was used...
August 31, 2018: Journal of Holistic Nursing: Official Journal of the American Holistic Nurses' Association
https://www.readbyqxmd.com/read/30166276/recognition-of-emotions-conveyed-by-touch-through-force-sensitive-screens-observational-study-of-humans-and-machine-learning-techniques
#19
Alicia Heraz, Manfred Clynes
BACKGROUND: Emotions affect our mental health: they influence our perception, alter our physical strength, and interfere with our reason. Emotions modulate our face, voice, and movements. When emotions are expressed through the voice or face, they are difficult to measure because cameras and microphones are not often used in real life in the same laboratory conditions where emotion detection algorithms perform well. With the increasing use of smartphones, the fact that we touch our phones, on average, thousands of times a day, and that emotions modulate our movements, we have an opportunity to explore emotional patterns in passive expressive touches and detect emotions, enabling us to empower smartphone apps with emotional intelligence...
August 30, 2018: JMIR Mental Health
https://www.readbyqxmd.com/read/30160504/more-than-skin-deep-integration-of-skin-based-and-musculoskeletal-reference-frames-in-localization-of-touch
#20
Renata Sadibolova, Luigi Tamè, Matthew R Longo
The skin of the forearm is, in one sense, a flat 2-dimensional (2D) sheet, but in another sense approximately cylindrical, mirroring the 3-dimensional (3D) volumetric shape of the arm. The role of frames of reference based on the skin as a 2D sheet versus based on the musculoskeletal structure of the arm remains unclear. When we rotate the forearm from a pronated to a supinated posture, the skin on its surface is displaced. Thus, a marked location will slide with the skin across the underlying flesh, and the touch perceived at this location should follow this displacement if it is localized within a skin-based reference frame...
August 30, 2018: Journal of Experimental Psychology. Human Perception and Performance
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