keyword
https://read.qxmd.com/read/38533080/the-effect-of-12-week-core-strength-training-on-dynamic-balance-agility-and-dribbling-skill-in-adolescent-basketball-players
#21
JOURNAL ARTICLE
Weiwei Feng, Feng Wang, Yan Han, Gui Li
PURPOSE: The purpose of the study was to examine the impact of core strength training on the dynamic balance, agility, and dribbling ability of adolescent basketball players. METHODS: A randomized controlled between-subjects design was employed. Forty-four male adolescent basketball players (aged 14.41 ± 3.22 years) were randomly divided into two groups: the core strength training (CST) group and the conventional training (CT) group. The CST program included 1-h sessions, three times/week for 12 weeks...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38533049/secretion-of-ifn-%C3%AE-by-specific-t-cells-in-hcmv-infection
#22
JOURNAL ARTICLE
Hanying Liang, Shengnan Gong, Genyong Gui, Huiqi Wang, Lili Jiang, Xuejie Li, Jun Fan
One major risk for recipients undergoing allogeneic hematopoietic stem cell transplants (allo-HSCTs) is infection with the human cytomegalovirus (HCMV). For HCMV treatment, it is especially crucial to be able to differentiate between recipients who are at high risk of reactivation and those who are not. In this study, HCMV-DNA was collected from 60 HLA-A*02 allo-HSCT recipients before and after transplantation. After transplantation, the release of interferon (IFN)-γ by T cells specific to HCMV was assessed using the enzyme-linked immunospot assay (ELISPOT)...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38531563/association-between-body-mass-index-and-delirium-incidence-in-critically-ill-patients-a-retrospective-cohort-study-based-on-the-mimic-iv-database
#23
JOURNAL ARTICLE
Jianlei Fu, Xuepeng Zhang, Geng Zhang, Canzheng Wei, Qinyi Fu, Xiying Gui, Yi Ji, Siyuan Chen
OBJECTIVES: Delirium is a form of brain dysfunction with high incidence and is associated with many negative outcomes in the intensive care unit. However, few studies have been large enough to reliably examine the associations between body mass index (BMI) and delirium, especially in critically ill patients. The objective of this study was to investigate the association between BMI and delirium incidence in critically ill patients. DESIGN: A retrospective cohort study...
March 25, 2024: BMJ Open
https://read.qxmd.com/read/38529960/correction-for-huang-et-al-chemotherapeutic-drugs-induce-different-gut-microbiota-disorder-pattern-and-nod-rip2-nf-%C3%AE%C2%BAb-signaling-pathway-activation-that-lead-to-different-degrees-of-intestinal-injury
#24
JOURNAL ARTICLE
Bin Huang, Mengxuan Gui, Zhuona Ni, Yanbin He, Jinyan Zhao, Jun Peng, Jiumao Lin
No abstract text is available yet for this article.
March 26, 2024: Microbiology Spectrum
https://read.qxmd.com/read/38529682/photogenerated-chlorine-radicals-activate-c-sp3-h-bonds-of-alkylbenzenes-to-access-quinazolinones
#25
JOURNAL ARTICLE
Xin-Yao Pan, Gui-Xia Sun, Fang-Ping Huang, Wen-Jian Qin, Qing-Hu Teng, Kai Wang
An Fe-catalyzed visible-light induced condensation of alkylbenzenes with anthranilamides has been developed. Upon irradiation, the trivalent iron complex could generate chlorine radicals, which successfully abstracted the hydrogen of benzylic C-H bonds to form benzyl radicals. And these benzyl radicals were converted into oxygenated products under air conditions, which subsequently reacted with anthranilamides for the synthesis of quinazolinones.
March 26, 2024: Organic & Biomolecular Chemistry
https://read.qxmd.com/read/38529653/the-relationship-between-quantitative-parameters-of-dual-energy-ct-and-hif-1%C3%AE-expression-in-non-small-cell-lung-cancer
#26
JOURNAL ARTICLE
Xi-Wen Meng, Ya-Wen Pi, Guang-Li Wang, Shu-Na Qi, Gui-Hui Zhang, Yu-Xia Cheng
OBJECTIVE: This study aimed to investigate whether there is a correlation between quantitative parameters of dual-energy computed tomography (DECT) and the relative expression of HIF-1α in patients with non-small cell lung cancer (NSCLC) to preliminarily explore the value of DECT in evaluating the hypoxia of tumor microenvironment and tumor biological behavior and provide more information for the treatment of NSCLC. METHODS: This retrospective research included 36 patients with pathologically confirmed NSCLC who underwent dual-energy enhanced CT scans...
March 19, 2024: Current medical imaging
https://read.qxmd.com/read/38528280/combined-brain-topological-metrics-with-machine-learning-to-distinguish-essential-tremor-and-tremor-dominant-parkinson-s-disease
#27
JOURNAL ARTICLE
Pan Xiao, Qin Li, Honge Gui, Bintao Xu, Xiaole Zhao, Hongyu Wang, Li Tao, Huiyue Chen, Hansheng Wang, Fajin Lv, Tianyou Luo, Oumei Cheng, Jin Luo, Yun Man, Zheng Xiao, Weidong Fang
BACKGROUND: Essential tremor (ET) and Parkinson's disease (PD) are the two most prevalent movement disorders, sharing several overlapping tremor clinical features. Although growing evidence pointed out that changes in similar brain network nodes are associated with these two diseases, the brain network topological properties are still not very clear. OBJECTIVE: The combination of graph theory analysis with machine learning (ML) algorithms provides a promising way to reveal the topological pathogenesis in ET and tremor-dominant PD (tPD)...
March 25, 2024: Neurological Sciences
https://read.qxmd.com/read/38527960/atropisomeric-carboxylic-acids-synthesis-via-nickel-catalyzed-enantioconvergent-carboxylation-of-aza-biaryl-triflates-with-co2
#28
JOURNAL ARTICLE
Xiao-Wang Chen, Chao Li, Yong-Yuan Gui, Jun-Ping Yue, Qi Zhou, Li-Li Liao, Jing-Wei Yang, Jian-Heng Ye, Da-Gang Yu
Upgrading CO2 to value-added chiral molecules via catalytic asymmetric C-C bond formation is a highly important yet challenging task. Although great progress on the formation of centrally chiral carboxylic acids has been achieved, catalytic construction of axially chiral carboxylic acids with CO2 has never been reported to date. Herein, we report the first catalytic asymmetric synthesis of axially chiral carboxylic acids with CO2, which is enabled by nickel-catalyzed dynamic kinetic asymmetric reductive carboxylation of racemic aza-biaryl triflates...
March 25, 2024: Angewandte Chemie
https://read.qxmd.com/read/38527657/microrna-30e-3p-regulates-the-inflammatory-response-by-targeting-the-gimap8-gene-in-ctenopharyngodon-idella-kidney-cik-cells
#29
JOURNAL ARTICLE
Lingli Xie, Biao Du, Hongyan Yu, Lang Gui, Junqiang Qiu, Li Yuan, Yubang Shen, Xiaoyan Xu, Jiale Li
Recent studies have increasingly linked miRNAs with the modulation of inflammatory responses and immunosuppressive activities. This investigation reveals that mir-30e-3p selectively binds to and modulates gimap8, as demonstrated by luciferase reporter assays and qPCR analyses. Upon LPS stimulation of CIK cells, mir-30e-3p expression was notably elevated, inversely correlating with a decrease in gimap8 mRNA levels. Overexpression of mir-30e-3p attenuated the mRNA levels of pro-inflammatory cytokines beyond the effect of LPS alone, suggesting a regulatory role of mir-30e-3p in inflammation mediated by the gimap8 gene...
March 23, 2024: Fish & Shellfish Immunology
https://read.qxmd.com/read/38527072/assessing-malnutrition-in-patients-with-nasopharyngeal-carcinoma-diagnostic-protocol-for-the-development-and-validation-of-a-new-nutritional-assessment-tool
#30
JOURNAL ARTICLE
Pengpeng Wang, Kim Lam Soh, Salimah Binti Japar, Huzwah Binti Khazaai, Jinlian Liao, Yanping Ying, Chuanyi Ning, Li Xue, Xiao Pan
INTRODUCTION: There is currently no gold standard or specific nutritional assessment tool to assess malnutrition in patients with nasopharyngeal carcinoma (NPC). Our study aims to develop a new nutritional assessment tool for NPC patients. METHODS AND ANALYSIS: NPC patients will be required to complete a risk factor questionnaire after obtaining their informed consent. The risk factor questionnaire will be used to collect potential risk factors for malnutrition...
2024: PloS One
https://read.qxmd.com/read/38526435/manganese-pentacarbonyl-bromide-as-regeneration-catalyst-enabled-biomimetic-asymmetric-reduction
#31
JOURNAL ARTICLE
Zheng Liu, Yan-Jiang Yu, Yu-Qing Bai, Mu-Wang Chen, Yong-Gui Zhou
Using readily available manganese pentacarbonyl bromide as a regeneration catalyst, biomimetic asymmetric reduction of imines including quinoxalinones, benzoxazinones, and benzoxazine has been successfully developed in the presence of transfer catalyst chiral phosphoric acids, providing the chiral amines with high yields and enantioselectivities.
March 25, 2024: Organic Letters
https://read.qxmd.com/read/38525789/emerging-ferroelectric-materials-scaln-applications-and-prospects-in-memristors
#32
REVIEW
Dong-Ping Yang, Xin-Gui Tang, Qi-Jun Sun, Jia-Ying Chen, Yan-Ping Jiang, Dan Zhang, Hua-Feng Dong
The research found that after doping with rare earth elements, a large number of electrons and holes will be produced on the surface of AlN, which makes the material have the characteristics of spontaneous polarization. A new type of ferroelectric material has made a new breakthrough in the application of nitride-materials in the field of integrated devices. In this paper, the application prospects and development trends of ferroelectric material ScAlN in memristors are reviewed. Firstly, various fabrication processes and structures of the current ScAlN thin films are described in detail to explore the implementation of their applications in synaptic devices...
March 25, 2024: Materials Horizons
https://read.qxmd.com/read/38525011/targeted-ultrasound-nanobubbles-therapy-for-prostate-cancer-via-immuno-sonodynamic-effect
#33
JOURNAL ARTICLE
Xin Huang, Yueying Chen, Fanglu Zhong, Bin Gui, Yugang Hu, Yuxin Guo, Qing Deng, Qing Zhou
BACKGROUND: Prostate cancer (PCa) poses a significant global health threaten. Immunotherapy has emerged as a novel strategy to augment the inhibition of tumor proliferation. However, the sole use of anti-PD-L1 Ab for PCa has not yielded improvements, mirroring outcomes observed in other tumor types. METHODS: This study employed the thin film hydration method to develop lipid nanobubbles (NBs) encapsulating chlorin e6 (Ce6) and anti-PD-L1 Ab (Ce6@aPD-L1 NBs). Our experimental approach included cellular assays and mouse immunization, providing a comprehensive evaluation of Ce6@aPD-L1 NBs' impact...
2024: International Journal of Nanomedicine
https://read.qxmd.com/read/38524450/molecular-dynamics-of-outer-membrane-embedded-polysaccharide-secretion-porins-reveals-closed-resting-state-surface-gates-targetable-by-virtual-fragment-screening-for-drug-hotspot-identification
#34
JOURNAL ARTICLE
Tanos C C França, Fares Saïdi, Alain Ajamian, Salim T Islam, Steven R LaPlante
Recent advances in iterative neural network analyses (e.g., AlphaFold2 and RoseTTA fold) have been revolutionary for protein 3D structure prediction, especially for difficult-to-manipulate α-helical/β-barrel integral membrane proteins. These model structures are calculated based on the coevolution of amino acids within the protein of interest and similarities to existing protein structures; the local effects of the membrane on folding and stability of the calculated model structures are not considered...
March 19, 2024: ACS Omega
https://read.qxmd.com/read/38523790/high-paternal-homocysteine-causes-ventricular-septal-defects-in-mouse-offspring
#35
JOURNAL ARTICLE
Lian Liu, Xuan Zhang, Hao-Ran Geng, Ya-Nan Qiao, Yong-Hao Gui, Jian-Yuan Zhao
Maternal hyperhomocysteinemia is widely considered as an independent risk of congenital heart disease (CHD). However, whether high paternal homocysteine causes CHD remains unknown. Here, we showed that increased homocysteine levels of male mice caused decreased sperm count, sperm motility defect and ventricular septal defect of the offspring. Moreover, high levels of paternal homocysteine decrease sperm DNMT3A/3B, accompanied with changes in DNA methylation levels in the promoter regions of CHD-related genes...
April 19, 2024: IScience
https://read.qxmd.com/read/38522955/effect-of-angiotensin-converting-enzyme-inhibitors-versus-that-of-angiotensin-receptor-blockers-on-survival-in-patients-undergoing-hemodialysis-a-nationwide-observational-cohort-study
#36
JOURNAL ARTICLE
Seok Hui Kang, Gui Ok Kim, Bo Yeon Kim, Eun Jung Son, Jun Young Do
BACKGROUND: This study aimed to evaluate the patient survival rates based on the use of angiotensin-converting enzyme inhibitor (ACEI) or angiotensin II receptor blocker (ARB) in a large cohort of patients undergoing maintenance hemodialysis (HD). METHODS: Data from a national HD quality assessment program were used in this retrospective study. The patients were classified into four groups based on the use of renin-angiotensin system blockers (RASBs) as follows: No group, patients without a prescription of any anti-hypertensive drugs including RASBs; Other group, patients with a prescription of anti-hypertensive drugs excluding RASBs; ACEI group, patients with a prescription of an ACEI; and ARB group, patients with a prescription of an ARB...
December 2024: Renal Failure
https://read.qxmd.com/read/38521771/ripk1-inhibitor-ameliorates-pulmonary-injury-by-modulating-the-function-of-neutrophils-and-vascular-endothelial-cells
#37
JOURNAL ARTICLE
Tao Yang, Cai-Gui Xiang, Xiao-Han Wang, Qing-Qing Li, Shu-Yue Lei, Kai-Rong Zhang, Jing Ren, Hui-Min Lu, Chun-Lan Feng, Wei Tang
Acute lung injury (ALI) is an acute and progressive hypoxic respiratory failure that could progress to acute respiratory distress syndrome (ARDS) with a high mortality rate, thus immediate medical attention and supportive care are necessary. The pathophysiology of ALI is characterized by the disruption of the alveolar-capillary barrier and activation of neutrophils, leading to lung tissue damage. The receptor-interacting protein kinase 1 (RIPK1) has emerged as a promising target for the treatment of multiple inflammatory diseases, but the role of RIPK1 in the ALI remains poorly understood...
March 23, 2024: Cell Death Discovery
https://read.qxmd.com/read/38521737/favorable-outcomes-of-liver-transplantation-for-hepatopulmonary-syndrome
#38
JOURNAL ARTICLE
Hao-Su Zhan, Lin Wei, Jing-Yi Liu, Hao-Feng Xiong, Wei Qu, Zhi-Gui Zeng, Fei Hou, Liang Zhang, Zhi-Jun Zhu, Li-Ying Sun
BACKGROUND: Hepatopulmonary syndrome (HPS) is a pulmonary vascular complication of chronic liver disease, which develops insidiously as a result of chronic liver disease. The prognosis for untreated patients with HPS is extremely poor, and liver transplantation (LT) serves as the only effective means for treating this condition. Here, we performed a retrospective analysis to evaluate the efficacy of LT on the survival and long-term prognosis of patients with HPS. METHODS: Clinical data, including survival and postoperative efficacy, from patients with HPS from records as obtained over the period from January 1 to December 31, 2022...
March 22, 2024: Transplantation Proceedings
https://read.qxmd.com/read/38521148/edi-oct-as-an-auxiliary-examination-for-the-differential-diagnosis-of-bullous-csc-and-vogt-koyanagi-harada-a-case-report
#39
Yuanyuan Zhang, Chenwei Gui, Tianyu Wang, Jianhao Bai, Zhongqi Wan, Lei Gao, Qing Peng
A 46-year-old male patient visited our clinic with a complaint of blurred vision in the right eye accompanied by headache and insomnia. The fundus examination showed three bullous retinal detachments in the right eye. Considering the prodromal symptoms and other fundus characteristics such as vitreous cells in the posterior pole and multifocal fluorescence leakages on fundus fluorescein angiography (FFA), initial diagnosis was considered as Vogt-Koyanagi-Harada (VKH). However, oral glucocorticoids didn't improve patient's vision...
March 21, 2024: Photodiagnosis and Photodynamic Therapy
https://read.qxmd.com/read/38520934/a-numerical-study-on-the-siphonic-effect-of-enhanced-external-counterpulsation-at-lower-extremities-with-a-coupled-0d-1d-closed-loop-personalized-hemodynamics-model
#40
JOURNAL ARTICLE
Qi Zhang, Ya-Hui Zhang, Li-Ling Hao, Xuan-Hao Xu, Gui-Fu Wu, Ling Lin, Xiu-Li Xu, Lin Qi, Shuai Tian
Enhanced external counterpulsation (EECP) is a treatment and rehabilitation approach for ischemic diseases, including coronary artery disease. Its therapeutic benefits are primarily attributed to the improved blood circulation achieved through sequential mechanical compression of the lower extremities. However, despite the crucial role that hemodynamic effects in the lower extremity arteries play in determining the effectiveness of EECP treatment, most studies have focused on the diastole phase and ignored the systolic phase...
March 19, 2024: Journal of Biomechanics
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