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https://www.readbyqxmd.com/read/30537285/il-37-alleviates-house-dust-mite-induced-chronic-allergic-asthma-by-targeting-tslp-through-the-nf-%C3%AE%C2%BAb-erk1-2-signaling-pathways
#1
Ping Meng, Zhuang-Gui Chen, Tian-Tuo Zhang, Zhuo-Zheng Liang, Xiao-Ling Zou, Hai-Ling Yang, Hong-Tao Li
Interleukin (IL)-37 has been described as a negative regulator of immune responses and is critical for asthma pathogenesis, but the mechanisms behind the protective role of IL-37 against allergic asthma are less well understood. We show here that IL-37 administered intranasally (i.n.) inhibited house dust mite (HDM)-induced chronic airway eosinophilic inflammation, goblet cell hyperplasia, peribronchial collagen deposition and airway hyperresponsiveness (AHR) to methacholine. In contrast to a weakened Th2 response in the lung that was characterized by the downregulation of Th2-associated cytokines and chemokines in IL-37-treated mice, IL-37 has no effect on relevant markers of systemic Th2 immune including serum immunoglobulins expression and in vitro production of Th2-associated cytokines by splenocytes on HDM recall...
December 11, 2018: Immunology and Cell Biology
https://www.readbyqxmd.com/read/30537038/downregulation-of-microrna-23b-protects-against-ischemia-reperfusion-injury-via-p53-signaling-pathway-by-upregulating-mdm4-in-rats
#2
Zhi Zhao, Jian-Zhong Guan, Min Wu, Gui-Hua Lai, Zhong-Lian Zhu
Total knee arthroplasty is a commonly performed safe procedure and typically executed in severe knee arthritis, but it also triggers ischemia-reperfusion injury (IRI). More recently, microRNAs (miRs) have been reported to play a contributory role in IRI through the key signaling pathway. Hence, the current study aimed to investigate the effect and specific mechanism of microRNA-23b (miR-23b), murine double minute 4 (MDM4), and the p53 signaling pathway in IRI rat models. First, the IRI model was established, and the expression pattern of miR-23b, MDM4, and the p53 signaling pathway-related genes was characterized in cartilaginous tissues...
December 9, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/30535477/cryptotanshinone-induces-reactive-oxygen-species%C3%A2-mediated-apoptosis-in-human-rheumatoid-arthritis-fibroblast%C3%A2-like-synoviocytes
#3
Hu-Nan Sun, Ying-Hua Luo, Ling-Qi Meng, Xian-Ji Piao, Yue Wang, Jia-Ru Wang, Hao Wang, Yi Zhang, Jin-Qian Li, Wan-Ting Xu, Yang Liu, Yu Zhang, Tong Zhang, Ying-Hao Han, Mei-Hua Jin, Gui-Nan Shen, Yan-Qing Zang, Long-Kui Cao, Dong-Jie Zhang, Cheng-Hao Jin
The present study investigated the mechanisms of apoptosis induced by cryptotanshinone (CT) in human rheumatoid arthritis fibroblast‑like synoviocytes (RA‑FLSs). Cell Counting kit‑8 assay was performed to determine the cytotoxic effects of CT in human RA‑FLSs, including primary RA‑FLS, HFLS‑RA and MH7A cells, and in HFLS cells derived from normal synovial tissue. Annexin V‑FITC/PI staining was used to detect the apoptotic effects of CT in HFLS‑RA and MH7A cells. Flow cytometry was performed to detect the apoptotic and reactive oxygen species (ROS) levels induced by CT in HFLS‑RA cells...
December 3, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/30535447/%C3%AE-%C3%A2-lipoic-acid-protects-against-carbon-tetrachloride%C3%A2-induced-liver-cirrhosis-through-the-suppression-of-the-tgf%C3%A2-%C3%AE-smad3-pathway-and-autophagy
#4
Guangwei Liu, Jiangkai Liu, Linping Pian, Songlin Gui, Baoping Lu
α‑lipoic acid (ALA) is a naturally occurring antioxidant with protective effects against various hepatic injuries. The aim of the present study was to investigate the mechanisms by which ALA protects the liver from carbon tetrachloride (CCl4)‑induced liver cirrhosis. The widely used liver cirrhosis rat model was established via an intraperitoneal injection of 2 mg/kg 50% CCl4, three times/week for 8 weeks. Simultaneously, 50 or 100 mg/kg ALA was orally administrated to the rats every day for 8 weeks...
December 4, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/30535429/overexpressed-plagl2-transcriptionally-activates-wnt6-and-promotes-cancer-development-in-colorectal-cancer
#5
Nanpeng Li, Daojiang Li, Yuheng Du, Chen Su, Chunxing Yang, Changwei Lin, Xiaorong Li, Gui Hu
Researchers hold the view that PLAGL2 is overexpressed in many malignancies and that it can promote tumor proliferation, migration, invasion and self‑renewal; however, there is no evidence revealing a relationship between PLAGL2 and colorectal cancer (CRC). In the present study, genes that are overexpressed in CRC were screened using the COSMIC database and GEPIA database and the expression of PLAGL2 in carcinoma tissues and pericarcinomatous tissues was detected by RT‑qPCR and western blot assays. A Cell Counting Kit‑8 assay, a cell cycle analysis experiment and a xenograft model were used to explore the influence of PLAGL2 on CRC after knocking down PLAGL2 expression in HCT116 and SW480 cells...
December 7, 2018: Oncology Reports
https://www.readbyqxmd.com/read/30533552/effects-of-deformation-twinning-on-the-mechanical-properties-of-biodegradable-zn-mg-alloys
#6
Shiyang Liu, Damon Kent, Nghiem Doan, Matthew Dargusch, Gui Wang
To satisfy the property requirements for biodegradable medical implants, Zn alloyed with low levels of Mg (≤0.8 wt%) has attracted increased research interest. In the present study, deformation twinning was observed in tensile tests and twinning appears to have an adverse impact on ductility. The profuse twinning in the as-cast Zn-Mg alloys accelerated crack growth in tension due to twinning impingement which caused local stress concentrations and initiates cracking. As-rolled Zn-Mg alloys have better ductility than their as-cast counterparts due to the inhibition of twinning by the refined Mg2 Zn11 intermetallic phase and the finer grain size...
March 2019: Bioactive Materials
https://www.readbyqxmd.com/read/30532543/activation-of-erk-creb-bdnf-pathway-involved-in-abnormal-behavior-of-neonatally-borna-virus-infected-rats
#7
Chenmeng Li, Xiaoyan Xu, Xiong Zhang, Ke Cheng, Yujie Guo, Jie Jie, Hua Guo, Yong He, Chanjuan Zhou, Siwen Gui, Xiaogang Zhong, Haiyang Wang, Peng Xie
Background: Neuropsychiatric disorders are devastating illnesses worldwide; however, the potential involvement of viruses in the pathophysiological mechanisms of psychiatric diseases have not been clearly elucidated. Borna disease virus (BDV) is a neurotropic, noncytopathic RNA virus. Materials and methods: In this study, we infected neonatal rats intracranially with BDV Hu-H1 and Strain V within 24 hours of birth. Psychological phenotypes were assessed using sucrose preference test, open field test, elevated plus maze test, and forced swim test...
2018: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/30531681/abnormal-dna-methylation-in-thoracic-spinal-cord-tissue-following-transection-injury
#8
Gui-Dong Shi, Xiao-Lei Zhang, Xin Cheng, Xu Wang, Bao-You Fan, Shen Liu, Yan Hao, Zhi-Jian Wei, Xian-Hu Zhou, Shi-Qing Feng
BACKGROUND Spinal cord injury (SCI) is a serious disease with high disability and mortality rates, with no effective therapeutic strategies available. In SCI, abnormal DNA methylation is considered to be associated with axonal regeneration and cell proliferation. However, the roles of key genes in potential molecular mechanisms of SCI are not clear. MATERIAL AND METHODS Subacute spinal cord injury models were established in Wistar rats. Histological observations and motor function assessments were performed separately...
December 8, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/30530426/severity-evaluation-and-prognostic-factors-in-erythrodermic-psoriasis
#9
Fenghui Ye, Xinyu Gui, Chao Wu, Xiaoling Yu, Hongzhong Jin
No abstract text is available yet for this article.
December 10, 2018: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/30530308/self-scanned-hifu-ablation-of-moving-tissue-using-real-time-hybrid-us-mr-imaging
#10
Orane Lorton, Pauline Guillemin, Nadia Mori, Lindsey Alexandra Crowe, Sana Boudabbous, Sylvain Terraz, Christoph Becker, Philippe C Cattin, Rares Salomir, Laura Gui
OBJECTIVE: High Intensity Focused Ultrasound (HIFU) treatment in the abdominal cavity is challenging due to the respiratory motion. In the self-scanning HIFU ablation method the focal spot is kept static and the heating pattern is obtained through natural tissue motion. This paper describes a novel approach for modulating the HIFU power during self-scanning in order to compensate for the effect of tissue motion on thermal build-up. METHODS: The therapy, using hybrid ultrasound (US) / magnetic resonance (MR) imaging, consists of detecting and tracking speckle on US images in order to predict the next tissue position, and modulating the HIFU power according to the tissue speed in order to obtain a rectilinear pattern of uniform temperature elevation...
December 5, 2018: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/30530135/high-risk-of-anxiety-and-depression-in-caregivers-of-adult-patients-with-epilepsy-and-its-negative-impact-on-patients-quality-of-life
#11
Xue-Rui Zhu, Ting Zhao, Hao Gu, Ya-Juan Gao, Na Wang, Pan Zhao, Ya-Nan Chen, Xiong Han, Gui-Nv He, Ming-Min Li, Bing-Qian Ma, Shi-Jun Yang
OBJECTIVE: The objective of this study was to assess the anxiety and depression of caregivers of adult patients with epilepsy (PWE) and evaluate its effect on patient quality of life (QOL). METHOD: One hundred sixty pairs of adult PWE and their caregivers were enrolled in our study. Quality of life in adult PWE was evaluated with the Quality of Life in Epilepsy Inventory-31 scale (QOLIE-31). Symptoms of anxiety and depression in caregivers were assessed with the Hamilton Anxiety Rating Scale (HAM-A) and the Hamilton Depression Rating Scale (HAM-D) respectively...
December 7, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/30529847/artemisianins-a-d-new-stereoisomers-of-seco-guaianolide-involved-heterodimeric-4-2-adducts-from-artemisia-argyi-induce-apoptosis-via-enhancement-of-endoplasmic-reticulum-stress
#12
Gui-Min Xue, Dong-Rong Zhu, Chao Han, Xiao-Bing Wang, Jian-Guang Luo, Ling-Yi Kong
Artemisianins A-D (1-4), four stereoisomers of sesquiterpenoid dimers, forming via [4+2] cycloaddition from a 1, 10-seco-guaianolide dienophile and a guaianolide diene, along with two biosynthetically related precurors 5 and 6, were isolated from the famous traditional Chinese medicine Artemisia argyi. The structures of 1-4, including their absolute configurations, were elucidated by extensive spectroscopic data and ECD/TDDFT calculation analysis. Compounds 1-4 exhibited cytotoxicity with IC50 values ranging from 7...
December 1, 2018: Bioorganic Chemistry
https://www.readbyqxmd.com/read/30529719/detection-and-genetic-characterization-of-kobuvirus-in-cats-the-first-molecular-evidence-from-northeast-china
#13
Ting-Jiang Niu, Shuai-Shu Yi, Xin Wang, Lei-Hua Wang, Bing-Yan Guo, Li-Yan Zhao, Shuang Zhang, Hao Dong, Kai Wang, Xue-Gui Hu
Feline kobuvirus (FeKoV), a novel picornavirus of the genus kobuvirus, was initially identified in the feces of cats with diarrhea in South Korea in 2013. To date, there is only one report of the circulation of kobuvirus in cats in southern China. To investigate the presence and genetic variability of FeKoV in northeast China, 197 fecal samples were collected from 105 cats with obvious diarrhea and 92 asymptomatic cats in Shenyang, Jinzhou, Changchun, Jilin and Harbin regions, Northeast China, and viruses were detected by RT-PCR with universal primers targeting all kobuviruses...
December 6, 2018: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/30529406/effects-of-adjuvant-chemotherapy-in-t1n0m0-triple-negative-breast-cancer
#14
Yi-Xing Ren, Shuang Hao, Xi Jin, Fu-Gui Ye, Yue Gong, Yi-Zhou Jiang, Zhi-Ming Shao
OBJECTIVES: Patients with T1N0M0 breast cancers are considered to have an excellent prognosis, even in triple-negative breast cancer (TNBC), which is often associated with diminished recurrence-free survival (RFS) and overall survival. Chemotherapy remains the only adjuvant treatment for TNBC, but evidence that adjuvant chemotherapy is beneficial for stage T1N0M0 TNBC patients is limited. In this study, we aimed to evaluate the effect of adjuvant chemotherapy and the benefit of taxanes in T1N0M0 TNBC patients...
November 28, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/30529065/lactone-ring-opening-seco-guaianolide-involved-heterodimers-linked-via-an-ester-bond-from-artemisia-argyi-with-no-inhibitory-activity
#15
Gui-Min Xue, Dong-Rong Zhu, Tian-Yu Zhu, Xiao-Bing Wang, Jian-Guang Luo, Ling-Yi Kong
Investigation into the chemical diversity of Artemisia argyi led to the discovery of four new (1-4) and one known (5) guaianolide sesquitenpenoid dimers linked via ester bond, and five other known mono-sesquiterpenoids (6-10). Their structures were determined via extensive spectroscopic data, and the absolute configurations of these compounds were elucidated by calculated ECD analysis and chemical method. The dimeric sesquiterpenoids exhibited NO production inhibitory activity with IC50 values ranging from 7...
December 4, 2018: Fitoterapia
https://www.readbyqxmd.com/read/30528569/pvax1-a20-alleviates-colitis-in-mice-by-promoting-regulatory-t-cells
#16
Tianyong Hu, Wenhui Hu, Li Ma, Xianhai Zeng, Jiangqi Liu, Baohui Cheng, Pingchang Yang, Shuqi Qiu, Gui Yang, Donghui Chen, Zhiqiang Liu
AIM: To investigate whether the intrarectal administration of the ubiquitin E3 ligase A20 (A20) attenuates intestinal inflammation and influences regulatory T cells in experimental colitis. METHODS: A dextran sulfate sodium induced chronic colitis mouse model was established. The symptoms and manifestations of colitis and the severity of colonic mucosal inflammation were evaluated. The protective role of A20 expression in the intestine was analyzed after the administration of a pVAX1-A20 recombinant eukaryotic vector, which was encapsulated into poly(L-lactide-co-glycolide) as a nanoparticle...
November 17, 2018: Digestive and Liver Disease
https://www.readbyqxmd.com/read/30527681/microrna-6807-3p-promotes-the-tumorigenesis-of-glioma-by-targeting-downstream-dach1
#17
Gui-Feng Lu, Fei Geng, Zhi Xiao, Yuan-Shou Chen, Yong Han, Chun-Yue You, Nan-Ling Gong, Ze-Mei Xie, Min Pan
Accumulated evidence reveals that microRNAs play vital roles in various tumors, including gliomas. MiRNAs have been shown to participate in multiple cellular functions, including cell proliferation, migration and apoptosis. Here, we investigate the potential role of a novel miRNA, miR-6807-3p, in glioma. A quantitative reverse transcription-polymerase chain reaction (RT-qPCR) and western blot were applied to detect the expression of miR-6807-3p and its target molecule in glioma specimens and cultured cells...
December 5, 2018: Brain Research
https://www.readbyqxmd.com/read/30526821/seroprevalence-of-toxoplasma-gondii-infection-and-variables-associated-with-seropositivity-in-donkeys-in-eastern-china
#18
Qing-Feng Meng, Dan Li, Gui-Zhe Yao, Yang Zou, Wei Cong, Xiao-Feng Shan
Donkeys (Equus asinus) are widely distributed throughout China; they are used for their meat, as food, and certain donkey-derived items are also important for traditional Chinese medicinal purposes. However, only limited information is available on Toxoplasma gondii infection in donkeys in China, especially the eastern region, which is one of the largest production areas. Thus, the present study was conducted to detect specific anti-T. gondii antibodies using a commercially available indirect hemagglutination test (IHA) kit and to evaluate the risk factors that are associated with seroprevalence in the Shandong province of eastern China...
2018: Parasite: Journal de la Société Française de Parasitologie
https://www.readbyqxmd.com/read/30526708/suicidal-behaviours-among-chinese-adolescents-exposed-to-suicide-attempt-or-death
#19
Zhen-Zhen Liu, Ze-Ying Wang, Qi-Gui Bo, Zhen-Biao Qi, Ru-Juan Xu, Cun-Xian Jia, Xianchen Liu
AimsSuicidal behaviours in adolescents are prevalent and multifactorial. This study was conducted to examine the associations between exposure to suicide attempt (ESA) or suicide death (ESD) and suicidal behaviours in a large sample of Chinese adolescents. METHODS: Participants included for the analysis were 11 831 adolescent students who participated in the baseline survey of the Shandong Adolescent Behavior and Health Cohort (SABHC). Participants were sampled from five middle and three high schools in three counties of Shandong province, China...
December 11, 2018: Epidemiology and Psychiatric Sciences
https://www.readbyqxmd.com/read/30526651/basal-position-of-two-new-complete-mitochondrial-genomes-of-parasitic-cymothoida-crustacea-isopoda-challenges-the-monophyly-of-the-suborder-and-phylogeny-of-the-entire-order
#20
Cong J Hua, Wen X Li, Dong Zhang, Hong Zou, Ming Li, Ivan Jakovlić, Shan G Wu, Gui T Wang
BACKGROUND: Isopoda is a highly diverse order of crustaceans with more than 10,300 species, many of which are parasitic. Taxonomy and phylogeny within the order, especially those of the suborder Cymothoida Wägele, 1989, are still debated. Mitochondrial (mt) genomes are a useful tool for phylogenetic studies, but their availability for isopods is very limited. To explore these phylogenetic controversies on the mt genomic level and study the mt genome evolution in Isopoda, we sequenced mt genomes of two parasitic isopods, Tachaea chinensis Thielemann, 1910 and Ichthyoxenos japonensis Richardson, 1913, belonging to the suborder Cymothoida, and conducted comparative and phylogenetic mt genomic analyses across Isopoda...
December 10, 2018: Parasites & Vectors
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