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Seung Woo Chung, Gui Chul Kim, Seho Kweon, Hanul Lee, Jeong Uk Choi, Foyez Mahmud, Hyo Won Chang, Ji Won Kim, Woo-Chan Son, Sang Yoon Kim, Youngro Byun
Metronomic chemotherapy, which is defined as a low-dose and frequent administration of cytotoxic drugs without drug-free breaks, has been recently emerged as an alternative to traditional MTD therapy and has shown therapeutic benefit in breast cancer patients in numbers of clinical studies. Unlike MTD, metronomic chemotherapy acts by multiple mechanisms including antiangiogenic effect and immunomodulation, but the direct cytotoxic effect only playing a minor role due to the lowered dose. In this light, within the limits of p53-deficient breast cancer, we demonstrate the enhanced anticancer effect of metronomic chemotherapy using doxorubicin when combined with Chk1 inhibitor MK-8776 by specifically augmenting the direct cytotoxic effect on cancer cells...
August 7, 2018: Biomaterials
Wenfei Song, Miao Gui, Xinquan Wang, Ye Xiang
The trimeric SARS coronavirus (SARS-CoV) surface spike (S) glycoprotein consisting of three S1-S2 heterodimers binds the cellular receptor angiotensin-converting enzyme 2 (ACE2) and mediates fusion of the viral and cellular membranes through a pre- to postfusion conformation transition. Here, we report the structure of the SARS-CoV S glycoprotein in complex with its host cell receptor ACE2 revealed by cryo-electron microscopy (cryo-EM). The complex structure shows that only one receptor-binding domain of the trimeric S glycoprotein binds ACE2 and adopts a protruding "up" conformation...
August 13, 2018: PLoS Pathogens
Fei Qi, Wei-Hu Wang, Xiao-Hui He, Bo Chen, Lin Gui, Hui Fang, Peng Liu, Shu-Lian Wang, Jian-Liang Yang, Yong-Wen Song, Sheng Yang, Shu-Nan Qi, Sheng-Yu Zhou, Ye-Xiong Li, Mei Dong
PURPOSE: To investigate the efficacy and toxicity profile of sequential intensity modulated radiation therapy (IMRT) followed by gemcitabine, dexamethasone, and cisplatin (GDP) on previously untreated high-risk, early stage upper aerodigestive tract natural killer/T-cell lymphoma (UADT-NKTCL). METHODS AND MATERIALS: A phase 2 study was designed, and 40 high-risk patients with stage I(E)/II(E) UADT-NKTCL were enrolled between June 2010 and June 2014. High-risk patients were defined as those with at least 1 predefined risk factor: age >60 years, elevated serum lactate dehydrogenase, regional lymph node involvement, B symptoms, and primary tumor invasion...
September 1, 2018: International Journal of Radiation Oncology, Biology, Physics
Li-Fang Huang, Si-Jie Gui, Yan-Ping Wan, Fang-Hua Gong, Dian Wang, Wen-Jing Yan, Ru-Lei Ding, Li Zhou, Gu-Qing Zeng
BACKGROUND Symptom distress is very common in patients with nasopharyngeal carcinoma (NPC) during radiotherapy, seriously affecting their quality of life and impeding the process of rehabilitation. Resourcefulness training can enhance the level of resourcefulness and benefit-finding, palliate symptom distress, and promote disease rehabilitation. However, the effects of resourcefulness training on local complications and benefit-finding in NPC patients during radiotherapy remains poorly understood. MATERIAL AND METHODS Questionnaires and resourcefulness training intervention were used in this study...
August 13, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Miao Wei, Meng Feng, Yue Guan, Ce Guo, Hang Zhou, Yongfeng Fu, Hiroshi Tachibana, Xunjia Cheng
Entamoeba nuttalli infection is prevalent in captive and wild macaques. Recent studies have suggested that genotypes of E. nuttalli isolates are correlated with the geographical distribution of host macaques. Correlation of amoebic genotypes with genetic diversity of host macaques was analyzed in present study. Sixty fresh stool samples were obtained from wild Tibetan macaques living in Mount Huang (HS) of the An-hui Province in China. PCR analysis revealed that the most prevalent Entamoeba species was E. chattoni (E...
August 10, 2018: Bioscience Trends
Wei Luo, Yong He, Fei Ding, Xin Nie, Xiao-Ling Li, Hao-Lan Song, Gui-Xing Li
BACKGROUND: The main risk factors for atherosclerosis patients are not fully explicated. The aim of this study was to analyze the levels of blood lipid and glycosylated lipoprotein in patients with coronary artery atherosclerosis and healthy individuals and to study the relationship between the glycosylated lipoprotein and atherosclerosis. METHODS: The study involved 200 patients diagnosed with myocardial infarction caused by coronary atherosclerosis as case group and 230 healthy individuals as control group...
August 12, 2018: Journal of Clinical Laboratory Analysis
Lijuan Gui, Zhenwei Yuan, Habtamu Kassaye, Jinrong Zheng, Yuxin Yao, Fei Wang, Qing He, Yuanzhi Shen, Li Liang, Haiyan Chen
A glucosamine modified near-infrared cyanine dye CyT sensitive to pH was synthesized. Due to the different pH values of mitochondria and autolysosomes, the probe can simultaneously investigate mitochondria and autolysosomes in living cells. Moreover, due to the introduction of glucosamine groups, this fluorescent probe can be applied for tumor targeted imaging.
August 13, 2018: Chemical Communications: Chem Comm
Gui-Li Yang, Lu-Yuan Li
Vascular hyperpermeability occurs in angiogenesis and several pathobiological conditions, producing elevated interstitial fluid pressure and lymphangiogenesis. How these closely related events are modulated is a fundamentally important question regarding the maintenance of vascular homeostasis and treatment of disease conditions such as cancer, stroke, and myocardial infarction. Signals mediated by vascular endothelial growth factor receptors, noticeably VEGFR-1, -2, and -3, are centrally involved in the promotion of both blood vessel and lymphatic vessel growth...
2018: Signal Transduction and Targeted Therapy
Yu Wang, Ying Zhou, Pei-Jun Li, Xi-Xi Wang, Ke-Zhou Cai, Cong-Gui Chen
The combined effect of calcium chloride (CaCl2 ) (20-100 mM) and high pressure processing (HPP, 200 MPa) on the solubility of myofibrillar proteins (MP) was investigated under sodium-reduced conditions (0.3 M sodium chloride). The results revealed that HPP combined with low concentrations (<40 mM) of CaCl2 synergistically increased the solubility of MP, but an antagonistic effect occurred when a high concentration (100 mM) of CaCl2 was present. This synergistic effect could be attributed to a mildly destabilized conformation of myosin, an increased surface hydrophobicity and the decreased total sulfhydryl group content of MP...
December 15, 2018: Food Chemistry
Jia-Wei Xu, Li Zheng, Li-Juan Li, Yu-Fei Yao, He Hua, Shi-Zhen Yang, Yi-Fan Wen, Cheng-Chuang Song, Xiu-Kai Cao, Kun-Peng Liu, Gui-Min Zhang, Jia-Meng Yang, Dan Hao, Rui-Hua Dang, Xian-Yong Lan, Chu-Zhao Lei, Xing-Lei Qi, Hong Chen, Yong-Zhen Huang
Copy number variation (CNV) related to complex traits, such as disease and quantitative phenotype, is considered an important and wealthy source of genetic and phenotypic diversity. It suggests that the copy number variation of function gene maybe leads to the phenotypic changes. Kupple like factor 3 (KLF3) gene is a vital transcription factor associated with the growth and development of muscle and adipose tissue. It has been mapped in a CNV region by animal genome re-sequencing. In this study, we detected the distribution diversity of KLF3 gene copy numbers in six Chinese cattle breeds (QC, NY, XN, PN, QDM and JX) and associated the phenotypic traits with it...
August 9, 2018: Gene
Orane Lorton, Jean-Noël Hyacinthe, Stéphane Desgranges, Laura Gui, Antoine Klauser, Zarko Celicanin, Lindsey A Crowe, François Lazeyras, Eric Allémann, Nicolas Taulier, Christiane Contino-Pépin, Rares Salomir
OBJECTIVE: Perfluorocarbon nano- and micron-sized emulsions are a new field of investigation in cancer treatment due to their ability to be used as imaging contrast agents, or as delivery vectors for pharmaceuticals. They also demonstrated capability to enhance the efficiency of high intensity focused ultrasound thermo-therapy. In the context of new biomedical applications we investigated perfluorooctyl bromide (PFOB) theranostic droplets using 19 F NMR. Each droplet contains biocompatible fluorinated surfactants composed of a polar Tris(hydroxymethyl)aminomethane head unit and hydrophobic perfluorinated tail (abbreviated as F-TAC)...
August 2, 2018: Journal of Magnetic Resonance
Yu-Te Yang, Jia-Hong Meng, Bin Hu, Chi-Yuan Ma, Chen-Chen Zhao, Wang-Si-Yuan Teng, Jian-Qiao Hong, Si-Hao Li, Guang-Yao Jiang, Cong Wang, Chen-He Zhou, Shi-Gui Yan
AIMS: Postmenopausal osteoporosis is a bone metabolism disease that is caused by an imbalance between bone-resorbing osteoclast and bone-forming osteoblast actions. Herein, we describe the role of troxerutin (TRX), a trihydroxyethylated derivative of rutin, in ovariectomy (OVX)-induced osteoporosis and its effects on the regulation of osteoclasts and osteoblasts. MAIN METHODS: In vivo, OVX female mice were intraperitoneally injected with either saline, 50 mg/kg TRX, or 150 mg/kg TRX for 6 weeks and then sacrificed for micro-computed tomography analyses, histological analyses, and biomechanical testing...
August 7, 2018: Life Sciences
Gabriel Famulari, Marc-André Renaud, Christopher M Poole, Michael D C Evans, Jan Seuntjens, Shirin A Enger
Despite being considered the gold standard for brachytherapy dosimetry, Monte Carlo (MC) has yet to be implemented into a software for brachytherapy treatment planning. The purpose of this work is to present RapidBrachyMCTPS, a novel treatment planning system (TPS) for brachytherapy applications equipped with a graphical user interface (GUI), optimization tools and a Geant4-based MC dose calculation engine, RapidBrachyMC. Brachytherapy sources and applicators were implemented in RapidBrachyMC and made available to the user via a source and applicator library in the GUI...
August 10, 2018: Physics in Medicine and Biology
Mehmet H Kural, Guohao Dai, Laura E Niklason, Liqiong Gui
OBJECTIVE: Invasive coronary interventions can fail due to intimal hyperplasia and restenosis. Endothelial cell (EC) seeding to the vessel lumen, accelerating re-endothelialization, or local release of mTOR pathway inhibitors have helped reduce intimal hyperplasia after vessel injury. While animal models are powerful tools, they are complex and expensive, and not always reflective of human physiology. Therefore, we developed an in vitro 3D vascular model validating previous in vivo animal models and utilizing isolated human arteries to study vascular remodeling after injury...
August 10, 2018: Cell Transplantation
Hui-Yan Liu, Jie Liu, Gui-Mei Gao, Hai-Ying Wang
Solvothermal reaction of 3,5-di(pyridin-4-yl) benzoic acid (HDPB) with Co(II) leads to a novel metal-organic framework, [Co2 O(DPB)2 (DMF)2 ]· xS (1), which represents a rare reo-type net with trigonal prismatic cobalt dimer, [Co2 O(CO2 )2 N4 ], as building blocks to construct a 3D framework containing three different types of nanoscale M12 L12 and M24 L12 polyhedron cages. More interestingly, under the same condition, the assembly of 4-methyl-3,5-di(pyridin-4-yl) benzoic acid (HMDPB) with Co(II) facilitates the formation of a cationic framework, [Co2 (MDPB)3 (DMF)](NO3 )· xS (2), with cobalt dimer, [Co2 (CO2 )3 N4 ], as building blocks...
August 10, 2018: Inorganic Chemistry
Zeng-Chun Wang, Qiang Chen, Hua Cao, Gui-Can Zhang, Liang-Wan Chen, Ling-Li Yu, Zeng-Rong Luo
No abstract text is available yet for this article.
July 9, 2018: Journal of Cardiothoracic and Vascular Anesthesia
You-Can Pan, Neng-Gui Xu, Wei Yi, Jun-Heng Shi, Xiao-Yan Zheng
OBJECTIVE: To observe the effect of electroacupuncture (EA) on changes of learning-memory ability, psychomotor coordination and anxiety-like behavior of cerebral hypoxic-ischemia (CHI) young rats, so as to explore its protective effect on neurons under hypoxic-ischemic conditions. METHODS: SD rats (aged 7 days) were randomly divided into sham operation (sham, n =12), model ( n =11), and EA groups ( n =12). In addition, 6 young rats in each group were used for observing the number of dendritic spines after Golgi staining...
June 25, 2018: Zhen Ci Yan Jiu, Acupuncture Research
Shuai Li, Jie Tan, Hong Zhang, Gui-Lan Huang, Duo-Xi Deng, Kui-Kui Guo, Jia-Qing Liu, Tong-Yan Liu, Yun-Yun Wu
OBJECTIVE: To observe the effect of catgut embedment at "Baihui" (GV 20), "Dazhui" (GV 14), etc. on learning-memory ability, expression of hippocampal protein kinase C interacting protein 1 (PICK 1) and glutamate receptor 2 (GluR 2) proteins and level of calcium ions, so as to explore its mechanism underlying improvement of vascular cognitive impairment. METHODS: A total of 56 male SD rats were randomly divided into sham operation, model, catgut embedment and medication groups ( n =14 in each)...
June 25, 2018: Zhen Ci Yan Jiu, Acupuncture Research
Xiao-Jun Li, Yun-Mei Mu, Qiu-Fang Qin, Zi-Xuan Zeng, Yu-Sang Li, Wei Kevin Zhang, He-Bin Tang, Gui-Hua Tian, Hong-Cai Shang
In the present study, intestinal tight junctions (TJs) and Kupffer cell polarization were investigated in an alcoholic steatohepatitis (ASH) mouse model to uncover the potential side effects of overexposure to fish oil or omega-3 fatty acids. The mice were fed ad libitum with a liquid diet containing ethanol and fish oil. In the meantime, ethanol was given every 5-7 days by gavage to simulate binge drinking. After the 7th binge, steatosis, necrosis, inflammatory infiltration, and bridging fibrosis were observed in the liver by histological staining...
September 1, 2017: Toxicology Research
Yang Li, Dan-Yun Ruan, Chang-Chang Jia, Jun Zheng, Guo-Ying Wang, Hui Zhao, Qing Yang, Wei Liu, Shu-Hong Yi, Hua Li, Gen-Shu Wang, Yang Yang, Gui-Hua Chen, Qi Zhang
Hepatic ischemia-reperfusion (I/R) injury fundamentally influences the performance of aged liver grafts. The significance of mitophagy in the age dependence of sensitivity to I/R injury remains poorly understood. Here, we show that aging aggravated hepatic I/R injury with decreased mitophagy in mice. The enhancement of mitophagy resulted in significant protection against hepatic I/R injury. Parkin, an E3 ubiquitin ligase, was found depleted by I/R in aged livers. In oxygen-glucose deprivation reperfusion (OGD-Rep...
August 8, 2018: Aging
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