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Ke Yang, Zhi-Yong Gao, Tie-Qiu Li, Wei Song, Wei Xiao, Jue Zheng, Hao Chen, Gui-Heng Chen, Hao-Yu Zou
In this study, a homogeneous polysaccharide (GTP), with a molecular weight of 7.0 × 104  Da, was isolated from Green tea, which was only composed of glucose. The antitumor effects of GTP on prostate cancer (PC) cell line along with the possible mechanism was examined. First, we investigate the potential role of microRNA-93 (miR-93) in PC progression. Our results showed that miR-93 was significantly upregulated in human PC tissues and several PC cell lines, and its overexpression was correlated with poor survival in PC patients...
October 17, 2018: International Journal of Biological Macromolecules
Alexey K Shaytan, Hua Xiao, Grigoriy A Armeev, Daria A Gaykalova, Galina A Komarova, Carl Wu, Vasily M Studitsky, David Landsman, Anna R Panchenko
Hydroxyl-radical footprinting (HRF) is a powerful method for probing structures of nucleic acid-protein complexes with single-nucleotide resolution in solution. To tap the full quantitative potential of HRF, we describe a protocol, hydroxyl-radical footprinting interpretation for DNA (HYDROID), to quantify HRF data and integrate them with atomistic structural models. The stages of the HYDROID protocol are extraction of the lane profiles from gel images, quantification of the DNA cleavage frequency at each nucleotide and theoretical estimation of the DNA cleavage frequency from atomistic structural models, followed by comparison of experimental and theoretical results...
October 19, 2018: Nature Protocols
Yang Zhang, Kun Ling Ma, Yu Xiang Gong, Gui Hua Wang, Ze Bo Hu, Liang Liu, Jian Lu, Pei Pei Chen, Chen Chen Lu, Xiong Zhong Ruan, Bi Cheng Liu
BACKGROUND: Glomerular endothelium dysfunction, which plays a crucial role in the pathogenesis of early diabetic nephropathy, might be caused by circulating metabolic abnormalities. Platelet microparticles, extracellular vesicles released from activated platelets, have recently emerged as a novel regulator of vascular dysfunction. METHODS: We studied the effects of platelet microparticles on glomerular endothelial injury in early diabetic nephropathy in rats with streptozotocin-induced diabetes and primary rat glomerular endothelial cells...
October 19, 2018: Journal of the American Society of Nephrology: JASN
Lei Dou, Yahong Zheng, Lu Li, Xiaowei Gui, Yajuan Chen, Meng Yu, Yi Guo
BACKGROUND: Polycystic ovary syndrome (PCOS) is the most prevalent cause of anovulatory infertility and hyperandrogenism. Evidence favors insulin resistance and compensatory hyperinsulinemia as the predominant, perhaps primary, defects in PCOS. The use of insulin-sensitizing drugs has been shown to improve both the reproductive and the metabolic aspects of PCOS. Cinnamon has been found to have insulin sensitizing effect and improve menstrual cyclicity in women with PCOS. The aim of this study was to determine the effect and mechanism of cinnamon on PCOS using a dehydroepiandrosterone (DHEA) induced PCOS mouse model...
October 19, 2018: Reproductive Biology and Endocrinology: RB&E
Huan Jiang, Gui-Jie Zhang, Hai-Bing Liao, Dong Liang
Two new cadinane sesquiterpene glucosides (1, 2), two new phenylpropanoid glycosides (3, 4), and two new diterpenoid glucosides (5, 6), as well as 6 known compounds were isolated from the stems of Tinospora sinensis. The structures of these compounds were elucidated by extensive spectroscopic analysis and chemical methods. The absolute configuration of compound 1 was determined by timedependent density functional theory (TDDFT) electronic circular dichroism (ECD) calculations and in situ dimolybdenum CD method...
October 16, 2018: Fitoterapia
Gui-Shi Liu, Yuwang Xu, Yifei Kong, Li Wang, Ji Wang, Xi Xie, Yunhan Luo, Bo-Ru Yang
Instability of silver nanowire (AgNW) has been regarded as a major obstacle to its practical applications in optoelectrical devices as transparent electrodes. Physical barrier layers such as polymer, metal, and graphene have been generally employed to improve the stability of AgNW in previous study. Herein, we first report self-assembled organothiols as an inhibitor for AgNW to achieve an overall enhancement in antioxidation, antisulfidation, thermal stability, and anti-electromigration. The self-assembled monolayers (SAMs) of phenyl azoles, methoxy silane, and methyl alkane were formed on the surface of AgNW via Ag-S covalent bond as barrier layers which provided protective effects against corrosives (e...
October 19, 2018: ACS Applied Materials & Interfaces
Jine Zhang, Xiaobing Chen, Qinghua Zhang, Furong Han, Jing Zhang, Hui Zhang, Hongrui Zhang, Hailin Huang, Shaojin Qi, Xi Yan, Lin Gu, Yuansha Chen, FengXia Hu, Shi-Shen Yan, Bang-Gui Liu, Baogen Shen, JiRong Sun
Interface engineering is an important approach leading to multifunctional artificial materials. While most of the previous works focused on the effects of the rotation/tilting of interfacial oxygen octahedron on perovskite multilayers, here we report on a new kind of lattice distortion characterized by an off-center shift of the Mn ions within the MnO6 oxygen octahedra at the interfaces of La1-x Srx CoO3 /La2/3 Sr1/3 MnO3 /La1-x Srx CoO3 /LaAlO3 trilayers (x=0-1/3), which drives the initially perpendicularly aligned magnetic axis of the La2/3 Sr1/3 MnO3 (LSMO) film towards in-plane direction though the film is in strongly compressive state...
October 19, 2018: ACS Applied Materials & Interfaces
Gui-Yan Liao, Shuai Zhao, Ting Zhang, Cheng-Xi Li, Lu-Sheng Liao, Feng-Fei Zhang, Xue-Mei Luo, Jia-Xun Feng
Background: Perfect and low cost of fungal amylolytic and cellulolytic enzymes are prerequisite for the industrialization of plant biomass biorefinergy to biofuels. Genetic engineering of fungal strains based on regulatory network of transcriptional factors (TFs) and their targets is an efficient strategy to achieve the above described aim. Talaromyces pinophilus produces integrative amylolytic and cellulolytic enzymes; however, the regulatory mechanism associated with the expression of amylase and cellulase genes in T...
2018: Biotechnology for Biofuels
Thomas Funck, Kevin Larcher, Paule-Joanne Toussaint, Alan C Evans, Alexander Thiel
APPIAN is an automated pipeline for user-friendly and reproducible analysis of positron emission tomography (PET) images with the aim of automating all processing steps up to the statistical analysis of measures derived from the final output images. The three primary processing steps are coregistration of PET images to T1-weighted magnetic resonance (MR) images, partial-volume correction (PVC), and quantification with tracer kinetic modeling. While there are alternate open-source PET pipelines, none offers all of the features necessary for making automated PET analysis as reliably, flexibly and easily extendible as possible...
2018: Frontiers in Neuroinformatics
Wellington Muchero, Kelsey L Sondreli, Jin-Gui Chen, Breeanna R Urbanowicz, Jin Zhang, Vasanth Singan, Yongil Yang, Robert S Brueggeman, Juan Franco-Coronado, Nivi Abraham, Jeong-Yeh Yang, Kelley W Moremen, Alexandra J Weisberg, Jeff H Chang, Erika Lindquist, Kerrie Barry, Priya Ranjan, Sara Jawdy, Jeremy Schmutz, Gerald A Tuskan, Jared M LeBoldus
Invasive microbes causing diseases such as sudden oak death negatively affect ecosystems and economies around the world. The deployment of resistant genotypes for combating introduced diseases typically relies on breeding programs that can take decades to complete. To demonstrate how this process can be accelerated, we employed a genome-wide association mapping of ca 1,000 resequenced Populus trichocarpa trees individually challenged with Sphaerulina musiva , an invasive fungal pathogen. Among significant associations, three loci associated with resistance were identified and predicted to encode one putative membrane-bound L-type receptor-like kinase and two receptor-like proteins...
October 18, 2018: Proceedings of the National Academy of Sciences of the United States of America
Ya-Wei Niu, Hua Liu, Guang-Hui Wang, Gui-Ying Yan
The last few decades have verified the vital roles of microRNAs in the development of human diseases and witnessed the increasing interest in the prediction of potential disease-miRNA associations. Owning to the open access of many miRNA-related databases, up until recently, kinds of feasible in silico models have been proposed. In this work, we developed a computational model of Maximal Entropy Random Walk on heterogenous network for MiRNA-disease Association prediction (MERWMDA). MERWMDA integrated known disease-miRNA association, pair-wise functional relation of miRNAs and pair-wise semantic relation of diseases into a heterogenous network comprised of disease and miRNA nodes full of information...
October 15, 2018: Mathematical Biosciences
Mi Deng, Xun Gui, Jaehyup Kim, Li Xie, Weina Chen, Zunling Li, Licai He, Yuanzhi Chen, Heyu Chen, Weiguang Luo, Zhigang Lu, Jingjing Xie, Hywyn Churchill, Yixiang Xu, Zhan Zhou, Guojin Wu, Chenyi Yu, Samuel John, Kouyuki Hirayasu, Nam Nguyen, Xiaoye Liu, Fangfang Huang, Leike Li, Hui Deng, Haidong Tang, Ali H Sadek, Lingbo Zhang, Tao Huang, Yizhou Zou, Benjamin Chen, Hong Zhu, Hisashi Arase, Ningshao Xia, Youxing Jiang, Robert Collins, M James You, Jade Homsi, Nisha Unni, Cheryl Lewis, Guo-Qiang Chen, Yang-Xin Fu, X Charlene Liao, Zhiqiang An, Junke Zheng, Ningyan Zhang, Cheng Cheng Zhang
Immune checkpoint blockade therapy has been successful in treating some types of cancer but has not shown clinical benefits for treating leukaemia1 . This result suggests that leukaemia uses unique mechanisms to evade this therapy. Certain immune inhibitory receptors that are expressed by normal immune cells are also present on leukaemia cells. Whether these receptors can initiate immune-related primary signalling in tumour cells remains unknown. Here we use mouse models and human cells to show that LILRB4, an immunoreceptor tyrosine-based inhibition motif-containing receptor and a marker of monocytic leukaemia, supports tumour cell infiltration into tissues and suppresses T cell activity via a signalling pathway that involves APOE, LILRB4, SHP-2, uPAR and ARG1 in acute myeloid leukaemia (AML) cells...
October 17, 2018: Nature
Hiroki Yoshioka, Tsunemasa Nonogaki, Hiroyuki Ohnishi, Nobuyuki Fukuishi, Masae Yoshikawa, Ming-Yu Gui, Yong-Ri Jin, Xu-Wen Li, Yoshiyuki Adachi, Naohito Ohno, Koichi Takeya, Yukio Hitotsuyanagi, Nobuhiko Miura, Yutaka Aoyagi
The present study aimed to investigate the protective effects of kamebakaurin (KA) and 1O, 20O-diacetyl kamebakaurin (Ac2 KA) on acetaminophen (APAP)-induced hepatotoxicity and compare the hepatoprotective mechanisms of the two chemicals. Seven-week-old male C57BL/6J mice were orally administered KA, Ac2 KA, or an ethanol/olive oil emulsion once per day for 7-days. Twenty-four hours after the final administration, the mice were fasted and then intraperitoneally injected with 450 mg/kg APAP or saline. At 16 h after injection, the mice were euthanized and blood samples were collected for plasma analysis...
2018: Biomedical Research
Ye Feng, Yan Liang, Xingwen Zhu, Mingjie Wang, Yuan Gui, Qingmiao Lu, Mengru Gu, Xian Xue, Xiaoli Sun, Weichun He, Junwei Yang, Randy L Johnson, Chunsun Dai
M2 macrophage polarization is known to underlie kidney fibrosis. We previously reported that most of the members of the Wnt family of signaling proteins are induced in fibrotic kidneys. Dysregulation of the signaling protein Wnt5a is associated with fibrosis, but little is known about the role of Wnt5a in regulating M2 macrophage activation that results in kidney fibrosis. Here, using murine Raw 264.7 cells and bone marrow-derived macrophages, we found that Wnt5a enhanced transforming growth factor β1 (TGFβ1)-induced macrophage M2 polarization as well as expression of the transcriptional regulators Yes-associated protein (Yap)/transcriptional coactivator with PDZ-binding motif (TAZ)...
October 17, 2018: Journal of Biological Chemistry
Li-Jie Zhou, Chun-Ling Zhang, Rui-Fen Zhang, Gui-Luan Wang, Yuan-Yuan Li, Yu-Jin Hao
SIZ1-mediated SUMO modification of target proteins is important for various biological processes related to abiotic stress resistance in plants; however, little is known about its role in resistance toward iron (Fe) deficiency. Here, the SUMO E3 ligase MdSIZ1 was shown to be involved in the plasma membrane (PM) H+-ATPase-mediated response to Fe deficiency. Subsequently, a basic helix-loop-helix (bHLH) transcription factor (TF), MdbHLH104, which acts as a key component in regulating PM H+-ATPase-mediated rhizosphere acidification and Fe uptake in apples (Malus domestica), was identified as a direct target of MdSIZ1...
October 17, 2018: Plant Physiology
Yong-Zhi Yang, Fan Liu, De-Bao Zhang, Gui-Shan Gu
No abstract text is available yet for this article.
September 25, 2018: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
Yingang Gui, Xiaoxing Zhang, Peigeng Lv, Shan Wang, Chao Tang, Qu Zhou
SF₆ decomposition components detection is a key technology to evaluate and diagnose the insulation status of SF₆-insulated equipment online, especially when insulation defects-induced discharge occurs in equipment. In order to detect the type and concentration of SF₆ decomposition components, a Ni-modified carbon nanotube (Ni-CNT) gas sensor has been prepared to analyze its gas sensitivity and selectivity to SF₆ decomposition components based on an experimental and density functional theory (DFT) theoretical study...
October 16, 2018: Sensors
Kurt Mills, Gui Wang, David StJohn, Matthew Dargusch
This study evaluated the effect of UltraSonic Treatment (UST) on a range of Al⁻Mg alloys. Previous research was carried out on single magnesium compositions. However, the amount and type of the alloy addition are known to affect the grain size even under UST, and the aim of this study was to determine whether or not alloy composition plays a similar role in the case of Al⁻Mg alloys. By testing binary Al⁻Mg alloys cast under regular casting conditions and under the presence of an ultrasonic field, it was found that while the addition of Mg solute is important, the amount of solute has little effect when UST is applied...
October 16, 2018: Materials
Qiuyue Gui, Jian Jiang, Yuanyuan Li, Jinping Liu
A one-pot route for coaxial growth of crystallized Co(OH)2 nanowire arrays on flexible carbon cloth (Co(OH)2/CC) has been developed for high-performance bendable pseudocapacitive electrodes. The hydrothermal process is found to result in in situ generation of hydrophilic groups on CC (in situ functionalized), changing its wettability and simultaneously helping the nucleation of Co(OH)2. Electrochemical tests evidence that the Co(OH)2/CC can function as a high-performance electrode with a high areal capacitance up to ∼1...
October 17, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
Cheng-Yong Jiang, Xiao-Yan Qin, Mi-Mi Yuan, Gui-Jiang Lu, Yong Cheng
Major depressive disorder (MDD) is a chronic mental disease that adversely affects human mood and cognition. Many first-line antidepressant drugs have high rates of partial responsiveness or nonresponsiveness with side effects, and finding more effective drugs for the treatment of depression is therefore urgently needed. THSG, a main active compound of the traditional Chinese herb Polygonum multiflorum , reportedly acts as a neuroprotective agent. This study aimed to illustrate whether THSG prevents depressive-like behaviors induced by chronic restraint stress (CRS) in an MDD mouse model...
2018: Oxidative Medicine and Cellular Longevity
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