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Metastasis head neck cancer

Ying-Ju Lai, Wan-Nien Yu, Sheng-Chu Kuo, Chi-Tang Ho, Chao-Ming Hung, Tzong-Der Way, Chiung-Tong Chen
Head and neck squamous cell carcinoma (HNSCC) is one of the leading causes of cancer deaths worldwide, especially in male. With poor prognosis, significant portions of patients with HNSCC die due to cancer recurrence and tumor metastasis after chemotherapy and targeted therapies. The HNSCC FaDu cell ectopic expression of Twist, a key transcriptional factor of epithelial-mesenchymal transition (EMT), which triggers EMT and results in the acquisition of a mesenchymal phenotype, was used as the cell model. Our results demonstrated that treatment with newly synthesized 2-(3-hydroxyphenyl)-5-methylnaphthyridin-4-one (CSC-3436), a flavonoid derivative, elicited changes in its cell morphology, upregulated E-cadherin messenger RNA and protein expression, downregulated N-cadherin, vimentin, and CD133 (a marker associated with tumor-initiating cells) in FaDu-pCDH-Twist cells...
October 20, 2018: Journal of Cellular Physiology
Chun-Wen Su, Mu-Kuan Chen, Wei-Chen Hung, Shun-Fa Yang, Chun-Yi Chuang, Chiao-Wen Lin
OBJECTIVES: Oral cancer is the most common head and neck malignancy, and it is associated with a high recurrence rate and lymph node metastasis potential. YKL-40, also known as chitinase-3-like protein 1 (CHI3L1), is a secreted glycoprotein that serves as a biomarker in several diseases. It also plays a crucial role in regulating many characteristics of cancer, such as cell growth, migration, anti-apoptosis, and angiogenesis. Accumulating evidence supports the link between single-nucleotide polymorphisms (SNPs) and oral cancer, but no report on the association between CHI3L1 polymorphisms and oral cancer is available...
October 19, 2018: Clinical Oral Investigations
Wei Gao, Chunming Zhang, Wenqi Li, Huizheng Li, Jiangwei Sang, Qinli Zhao, Yunfeng Bo, Hongjie Luo, Xiwang Zheng, Yan Lu, Yong Shi, Dongli Yang, Ruiping Zhang, Zhenyu Li, Jiajia Cui, Yuliang Zhang, Min Niu, Jun Li, Zhongqiang Wu, Huina Guo, Caixia Xiang, Juan Wang, Juan Hou, Lu Zhang, Rick F Thorne, Yongping Cui, Yongyan Wu, Shuxin Wen, Binquan Wang
Laryngeal squamous cell carcinoma (LSCC) is a common form of head and neck cancer with poor prognosis. However, the mechanism underlying the pathogenesis of LSCC remains unclear. Here, we demonstrated increased expression of fascin actin-bundling protein 1 (FSCN1) and decreased expression of microRNA-145-5p (miR-145-5p) in a clinical cohort of LSCC. Luciferase assay revealed that miR-145-5p is a negative regulator of FSCN1. Importantly, low miR-145-5p expression was correlated with TNM (tumor, node, metastasis) status and metastasis...
September 27, 2018: Molecular Therapy: the Journal of the American Society of Gene Therapy
Ling Gao, Hua Cao, Xiulian Cheng
Laryngeal squamous cell carcinoma (LSCC) is the second highest incidence among the head and neck malignancies. Long noncoding RNA (lncRNA) small nucleolar RNA host gene 1 (SNHG1) functions as an oncogene in various human cancers. However, the biological functions and molecular mechanisms of SNHG1 in LSCC have not been reported. In this study, we found that lncRNA SNHG1 is significantly upregulated in LSCC and associated with prognosis of LSCC patients. Knockdown of SNHG1 inhibited cell proliferation, migration and invasion and induced cell apoptosis...
2018: American Journal of Cancer Research
Hassan Nasser, Maie St John
Head and neck squamous cell carcinoma (HNSCC) is an immunosuppressive disease with multiple mechanisms to impair immune-mediated recognition and control of tumor cell proliferation and metastasis. Based on successes experienced with cancer immunotherapy in the treatment of other solid tumors, considerable efforts are underway to develop immunotherapeutics that can enhance the host antitumor response to HNSCC. Promising results in preclinical studies and early clinical trials have been reported, prompting the FDA to approve the use of the immune checkpoint PD-1 receptor antagonist pembrolizumab for the treatment of platinum-refractory recurrent or metastatic HNSCC in 2016...
2018: Critical Reviews in Oncogenesis
Changyun Yu, Yunyun Wang, Guo Li, Li She, Diekuo Zhang, Xiyu Chen, Xin Zhang, Zhaobing Qin, Hua Cao, Yong Liu
Long non-coding RNAs (lncRNAs) are potentially critical regulators of cancer malignant behaviours. Aberrant expression and dysfunction of lncRNA PVT1 have been reported in multiple human cancers. However, its role in squamous cell carcinoma of the head and neck (SCCHN) remains largely unknown. Our current study demonstrated that PVT1 expression was increased in SCCHN. High PVT1 expression was positively correlated with SCCHN clinical parameters including T classification, clinical stages and cervical lymph node metastasis...
2018: Journal of Cancer
Eric Adjei Boakye, Kenton J Johnston, Thiago A Moulin, Paula M Buchanan, Leslie Hinyard, Betelihem B Tobo, Sean T Massa, Nosayaba Osazuwa-Peters
OBJECTIVES: The aim of the study was to estimate hospitalization cost, and factors associated with hospitalization costs and length of stay (LOS) of patients treated for head and neck cancer in the United States. METHODS: Data on 71,440 weighted hospital admissions from the 2014 National Inpatient Sample with a diagnosis of head and neck cancer were examined. Multivariable linear regression models estimated factors associated with hospitalization costs, and negative binomial regression models were used to identify factors associated with hospital LOS...
October 8, 2018: American Journal of Clinical Oncology
David H Chafey, Valerae O Lewis, Robert L Satcher, Bryan S Moon, Patrick P Lin
BACKGROUND: Although cephalomedullary nail fixation is often used for metastatic peritrochanteric lesions of the femur, there is concern regarding the durability of the implant in comparison to endoprosthetic reconstruction. Previous studies have reported the proportion of patients who undergo reoperation for loss of stability, but the adequacy of the construct has not been critically evaluated in a competing risk analysis that incorporates death of the patient in the calculation. QUESTIONS/PURPOSES: (1) What is the cumulative incidence of reoperation of cephalomedullary nails with death as a competing risk for metastatic lesions of the proximal femur? (2) What is the survival of patients with metastases to the proximal femur after cephalomedullary nailing? (3) What clinical factors are associated with implant stability in these patients? METHODS: Between 1990 and 2009, 11 surgeons at one center treated 217 patients with cephalomedullary nails for metastatic proximal femoral lesions...
October 2, 2018: Clinical Orthopaedics and related Research
Daniel P Noij, Roland M Martens, Ben Zwezerijnen, Thomas Koopman, Remco de Bree, Otto S Hoekstra, Pim de Graaf, Jonas A Castelijns
BACKGROUND AND PURPOSE: Head and neck squamous cell carcinoma (HNSCC) may present with cervical metastases without an apparent primary tumor. Detecting the primary tumor results in more targeted treatment. Acquisition of DWI is improving with less artifacts and image distortion. We assessed the diagnostic value of DWI and 18 F-FDG-PET/CT for detecting primary tumors in patients presenting with nodal metastasis of an unknown primary HNSCC. MATERIALS AND METHODS: For this retrospective study we included 31 patients (male/female ratio = 23/8, median age = 66 years, age range = 40-80 years) who presented with a pathologically proven cervical nodal metastasis from HNSCC without overt primary tumor location between January 2013 and November 2016 and underwent both DWI and 18 F-FDG-PET/CT...
October 2018: European Journal of Radiology
Christiane Matuschek, Jan Haussmann, Edwin Bölke, Stephan Gripp, Patrick J Schuler, Bálint Tamaskovics, Peter Arne Gerber, Freddy-Joel Djiepmo-Njanang, Kai Kammers, Christian Plettenberg, Bahar Anooshahr, Klaus Orth, Wilfried Budach
BACKGROUND: Adjuvant radiotherapy in advanced head and neck squamous cell cancer (HNSCC) reduces the risk of local-regional failure and most likely increases the survival rate. Patients at high risk for tumor recurrence may benefit from more aggressive altered fractionation schedules in order to reduce the overall time from surgery to completion of radiotherapy. Here, we reviewed the results of six randomized trials addressing the above hypothesis. METHODS: In the six trials of interest, a total of 988 patients with locally advanced HNSCC were randomly assigned to receive either accelerated or conventionally fractionated adjuvant radiotherapy...
October 4, 2018: Radiation Oncology
Guomiao Zhao, Yaru Fu, Zhifang Su, Rongling Wu
BACKGROUND/AIMS: Long non-coding RNAs (lncRNAs) act as competing endogenous RNAs (ceRNAs) to compete for microRNAs (miRNAs) in cancer metastasis. Head and neck squamous cell carcinoma (HNSCC) is one of the most common human cancers and rare biomarkers could predict the clinical prognosis of this disease and its therapeutic effect. METHODS: Weighted gene co-expression network analysis (WGCNA) was performed to identify differentially expressed mRNAs (DEmRNAs) that might be key genes...
October 3, 2018: Cellular Physiology and Biochemistry
Tianzhu Lu, Hongjing Liu, Ganhua You
Oral squamous cell carcinoma (OSCC) is a major cancer type in the head and neck region. Recent studies have reported a marked rise in the incidence of OSCC. The present study was performed to better understand the roles that long non‑coding RNAs (lncRNAs) serve in OSCC carcinogenesis. The levels of the lncRNA C5orf66 antisense RNA 1 (C5orf66‑AS1) and of cytochrome c1 (CYC1) in OSCC tissues and cells were measured through reverse transcription‑quantitative polymerase chain reaction. In addition, the levels of associated proteins were analyzed by western blotting, while MTT assay was used to detect the cell proliferation ability...
October 2, 2018: International Journal of Molecular Medicine
Liang Dong, Xiaoming Lyu, Oluwasijibomi Damola Faleti, Ming-Liang He
The T-box factors belong to an ancient protein family, which comprises a cluster of evolutionarily-conserved transcription factors that regulate gene expression and that are crucial to embryonic development. T-box transcription factor 3 (Tbx3) is a member of this family, is expressed in some tissues, and is a key regulator in many critical organs, including the heart, mammary gland, and limbs. Overexpression of Tbx3 is associated with a number of cancers, including head and neck squamous cell carcinoma, gastric, breast, ovary, cervical, pancreatic, bladder and liver cancers, as well as melanoma...
September 27, 2018: Seminars in Cancer Biology
Yuanyuan Kang, Ying Zhang, Yan Sun, Yan Wen, Fuli Sun
Introduction: Oral cancer is the sixth most prevalent form of cancer, with oral squamous cell carcinomas (OSCCs) exhibiting the highest morbidity of all head and neck cancers. However, the specific metastatic mechanism is not yet clear. MicroR-300 (miR-300) has been identified as a critical regulator in tumor development. In this study, we focused on the roles of miR-300 in regulating epithelial-mesenchymal transition (EMT) in OSCC. Methods: The surgical specimens from cases of OSCC (N=120) were collected, and the miR-300 expression was tested and the results were analyzed for possible correlations with clinical characteristics, and the prognostic significance was assessed by Kaplan-Meier analysis and Cox proportional hazards regression in OSCC patients...
2018: OncoTargets and Therapy
Xin Pang, Ya-Ling Tang, Xin-Hua Liang
Head and neck squamous cell carcinoma (HNSCC) arises in the oral cavity, salivary glands, larynx, pharynx, nasal cavity and paranasal sinuses, and is characterized by high morbidity and metastasis rates. Transforming growth factor-β (TGF-β) is a homodimeric protein known to be a multifunctional regulator in target cells and to serve a pivotal role in numerous types of cancer, including HNSCC. The role of TGF-β signaling in carcinogenesis can change from tumor-suppressing to tumor-promoting. In addition, TGF-β induces epithelial-mesenchymal transition and restrains immune surveillance on malignant cells...
October 2018: Oncology Letters
Takayuki Imai, Shigemi Ito, Tomoyuki Oikawa, Yukinori Asada, Ko Matsumoto, Takefumi Miyazaki, Tomoko Yamazaki, Ikuro Satoh, Tetsuya Noguchi, Kazuto Matsuura
OBJECTIVE: Hypopharyngeal cancer is a head and neck cancer with a poor prognosis, and most cases show metastases on diagnosis. Cervical lymph node (LN) metastasis is a poor prognostic factor in hypopharyngeal cancer patients. The identification of risk factors for LN metastasis can help guide surgical treatment strategies for these patients. METHODS: This retrospective study included 93 superficial hypopharyngeal cancer patients with 109 histopathologically examined lesions treated by endoscopic resection between January 2007 and December 2017...
September 21, 2018: Auris, Nasus, Larynx
Jose P Zevallos, Angela L Mazul, Vonn Walter, David Neil Hayes
OBJECTIVES/HYPOTHESIS: Gene expression analyses of head and neck cancer have revealed four molecular subtypes: basal (BA), mesenchymal (MS), atypical (AT), and classical (CL). We evaluate whether gene expression subtypes in oral cavity squamous cell carcinoma (OCSCC) and laryngeal squamous cell carcinoma (LSCC) can be used to predict nodal metastasis and prognosticate survival. STUDY DESIGN: Retrospective cohort study and genomic analysis. METHODS: OCSCC and LSCC cases were identified from the The Cancer Genome Atlas (TCGA) head and neck cancer cohort...
September 24, 2018: Laryngoscope
Carolin Götz, Oliver Bissinger, Christopher Nobis, Klaus Dietrich Wolff, Enken Drecoll, Andreas Kolk
Long-term survival in cases of head and neck squamous cell carcinoma, particularly oral squamous cell carcinoma (OSCC), remains a rare achievement in the field of clinical oncology. In recent years, the theory of cancer stem cells (CSCs) has emerged and been used to offer explanations for tumour recurrence and metastasis. The present aim was to investigate the role of aldehyde dehydrogenase 1 (ALDH1) as a CSC-marker for OSCC and to determine the role of p16ink4a , which is also a surrogate marker of human papilloma virus (HPV), in the expression of ALDH1...
October 2018: Biomedical Reports
Lingqiong Zhao, Jie Liu, Shu Chen, Chun Fang, Xianquan Zhang, Zhibin Luo
Purpose: NANOG is a tumor marker and indicates poor prognosis in various neoplasms; however, the evidence is controversial. This meta-analysis investigated the association of NANOG expression and clinicopathological features, and it impact on survival of patients with malignant tumors. Methods: Studies published through May 31, 2018 were retrieved from PubMed, Web of Science, Embase, and the China National Knowledge Infrastructure. Two researchers independently screened the content and quality of studies and extracted data...
2018: OncoTargets and Therapy
Benjamin H Kann, Sanjay Aneja, Gokoulakrichenane V Loganadane, Jacqueline R Kelly, Stephen M Smith, Roy H Decker, James B Yu, Henry S Park, Wendell G Yarbrough, Ajay Malhotra, Barbara A Burtness, Zain A Husain
Identification of nodal metastasis and tumor extranodal extension (ENE) is crucial for head and neck cancer management, but currently only can be diagnosed via postoperative pathology. Pretreatment, radiographic identification of ENE, in particular, has proven extremely difficult for clinicians, but would be greatly influential in guiding patient management. Here, we show that a deep learning convolutional neural network can be trained to identify nodal metastasis and ENE with excellent performance that surpasses what human clinicians have historically achieved...
September 19, 2018: Scientific Reports
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