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https://www.readbyqxmd.com/read/29625905/myogenic-oxidative-imbalance-interferes-with-antral-motility-in-obese-subjects
#1
Annunziata Scirocco, Lucia Pallotta, Marco Rengo, Antonia Ignazzi, Marilia Carabotti, Alessia Cicenia, Rosa Vona, Piero Chirletti, Maria Antonietta Maselli, Rossella Donghia, Mariagrazia Coluzzi, Paola Matarrese, Gianfranco Silecchia, Carola Severi
BACKGROUND: Obesity is characterized by a systemic low-grade chronic inflammatory oxidative condition that affects vascular and cardiac smooth muscle relaxation. In human antrum, relaxation is mediated by vasoactive intestinal peptide (VIP) through cAMP and cGMP signaling pathways. A genome-wide association study has demonstrated an association between VIP and obesity. AIM: To evaluate smooth muscle activity in human obese antrum, both in in vitro preparations as well as in vivo...
March 14, 2018: Digestive and Liver Disease
https://www.readbyqxmd.com/read/29602461/left-ventricular-hypertrophy-as-protective-factor-after-bypass-grafting
#2
Gian Luca Iannuzzi, Mauro Maniscalco, Andrea Elia, Anna Scognamiglio, Giuseppe Furgi, Franco Rengo
Left ventricular hypertrophy (LVH) is a well established cardiovascular risk factor, accounting for an increase in cardiovascular morbid-mortality, although how much the magnitude and the kind of LVH could affect cardiovascular outcomes is in large part unknown. We speculate that mild LVH in absence of left ventricular (LV) chamber dilation, could play a protective role towards functional capacity, clinical outcome, cardiovascular and total morbi-mortality in conditions in which LV systolic function is generally reduced...
May 2018: Medical Hypotheses
https://www.readbyqxmd.com/read/29584683/mechanical-and-thermal-properties-of-dental-composites-cured-with-cad-cam-assisted-solid-state-laser
#3
Roberto De Santis, Antonio Gloria, Saverio Maietta, Massimo Martorelli, Alessandro De Luca, Gianrico Spagnuolo, Francesco Riccitiello, Sandro Rengo
Over the last three decades, it has been frequently reported that the properties of dental restorative composites cured with argon laser are similar or superior to those achieved with conventional halogen and light emitting diode (LED) curing units. Whereas laser curing is not dependent on the distance between the curing unit and the material, such distance represents a drawback for conventional curing units. However, a widespread clinical application of this kind of laser remains difficult due to cost, heavy weight, and bulky size...
March 27, 2018: Materials
https://www.readbyqxmd.com/read/29572708/klinefelter-syndrome-insulin-resistance-metabolic-syndrome-and-diabetes-review-of-literature-and-clinical-perspectives
#4
REVIEW
Andrea Salzano, Roberta D'Assante, Liam M Heaney, Federica Monaco, Giuseppe Rengo, Pietro Valente, Daniela Pasquali, Eduardo Bossone, Daniele Gianfrilli, Andrea Lenzi, Antonio Cittadini, Alberto M Marra, Raffaele Napoli
PURPOSE: Klinefelter syndrome (KS), the most frequent chromosomic abnormality in males, is associated with hypergonadotropic hypogonadism and an increased risk of cardiovascular diseases (CVD). The mechanisms involved in increasing risk of cardiovascular morbidity and mortality are not completely understood. This review summarises the current understandings of the complex relationship between KS, metabolic syndrome and cardiovascular risk in order to plan future studies and improve current strategies to reduce mortality in this high-risk population...
March 23, 2018: Endocrine
https://www.readbyqxmd.com/read/29535114/long-term-caloric-restriction-improves-cardiac-function-remodeling-adrenergic-responsiveness-and-sympathetic-innervation-in-a-model-of-postischemic-heart-failure
#5
Claudio de Lucia, Giuseppina Gambino, Laura Petraglia, Andrea Elia, Klara Komici, Grazia Daniela Femminella, Maria Loreta D'Amico, Roberto Formisano, Giulia Borghetti, Daniela Liccardo, Maria Nolano, Steven R Houser, Dario Leosco, Nicola Ferrara, Walter J Koch, Giuseppe Rengo
BACKGROUND: Caloric restriction (CR) has been described to have cardioprotective effects and improve functional outcomes in animal models and humans. Chronic ischemic heart failure (HF) is associated with reduced cardiac sympathetic innervation, dysfunctional β-adrenergic receptor signaling, and decreased cardiac inotropic reserve. We tested the effects of a long-term CR diet, started late after myocardial infarction on cardiac function, sympathetic innervation, and β-adrenergic receptor responsiveness in a rat model of postischemic HF...
March 2018: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29383117/magnetic-resonance-tumor-regression-grade-mr-trg-to-assess-pathological-complete-response-following-neoadjuvant-radiochemotherapy-in-locally-advanced-rectal-cancer
#6
Marco Rengo, Simona Picchia, Simona Marzi, Davide Bellini, Damiano Caruso, Mauro Caterino, Maria Ciolina, Domenico De Santis, Daniela Musio, Vincenzo Tombolini, Andrea Laghi
This study aims to evaluate the feasibility of a magnetic resonance (MR) automatic method for quantitative assessment of the percentage of fibrosis developed within locally advanced rectal cancers (LARC) after neoadjuvant radiochemotherapy (RCT). A total of 65 patients were enrolled in the study and MR studies were performed on 3.0 Tesla scanner; patients were followed-up for 30 months. The percentage of fibrosis was quantified on T2-weighted images, using automatic K-Means clustering algorithm. According to the percentage of fibrosis, an optimal cut-off point for separating patients into favorable and unfavorable pathologic response groups was identified by ROC analysis and tumor regression grade (MR-TRG) classes were determined and compared to histopathologic TRG...
December 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29198416/sleep-disordered-breathing-and-epicardial-adipose-tissue-in-patients-with-heart-failure
#7
V Parisi, S Paolillo, G Rengo, R Formisano, L Petraglia, F Grieco, C D'Amore, S Dellegrottaglie, C Marciano, N Ferrara, D Leosco, P P Filardi
BACKGROUND AND AIMS: Sleep-disordered breathing (SDB) is common in patients with heart failure (HF), contributes to the progression of cardiac disease, and is associated with adverse prognosis. Previous evidence indicates that epicardial adipose tissue (EAT) is independently associated with sleep apnea in obese individuals. We explored the relationship between SDB and EAT in HF patients. METHODS AND RESULTS: EAT thickness was assessed by echocardiography in 66 patients with systolic HF undergoing nocturnal cardiorespiratory monitoring...
February 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/29166798/grk2-as-a-therapeutic-target-for-heart-failure
#8
REVIEW
Alessandro Cannavo, Klara Komici, Leonardo Bencivenga, Maria Loreta D'amico, Giuseppina Gambino, Daniela Liccardo, Nicola Ferrara, Giuseppe Rengo
G protein-coupled receptor (GPCR) kinase-2 (GRK2) is a regulator of GPCRs, in particular β-adrenergic receptors (ARs), and as demonstrated by decades of investigation, it has a pivotal role in the development and progression of cardiovascular disease, like heart failure (HF). Indeed elevated levels and activity of this kinase are able to promote the dysfunction of both cardiac and adrenal α- and β-ARs and to dysregulate other protective signaling pathway, such as sphingosine 1-phospate and insulin. Moreover, recent discoveries suggest that GRK2 can signal independently from GPCRs, in a 'non-canonical' manner, via interaction with non-GPCR molecule or via its mitochondrial localization...
January 2018: Expert Opinion on Therapeutic Targets
https://www.readbyqxmd.com/read/29119525/haralick-s-texture-features-for-the-prediction-of-response-to-therapy-in-colorectal-cancer-a-preliminary-study
#9
COMPARATIVE STUDY
Damiano Caruso, Marta Zerunian, Maria Ciolina, Domenico de Santis, Marco Rengo, Mumtaz H Soomro, Gaetano Giunta, Silvia Conforto, Maurizio Schmid, Emanuele Neri, Andrea Laghi
PURPOSE: Haralick features Texture analysis is a recent oncologic imaging biomarker used to assess quantitatively the heterogeneity within a tumor. The aim of this study is to evaluate which Haralick's features are the most feasible in predicting tumor response to neoadjuvant chemoradiotherapy (CRT) in colorectal cancer. MATERIALS AND METHODS: After MRI and histological assessment, eight patients were enrolled and divided into two groups based on response to neoadjuvant CRT in complete responders (CR) and non-responders (NR)...
March 2018: La Radiologia Medica
https://www.readbyqxmd.com/read/29033559/pressure-injuries-in-elderly-with-acute-myocardial-infarction
#10
Klara Komici, Dino F Vitale, Dario Leosco, Angela Mancini, Graziamaria Corbi, Leonardo Bencivenga, Alessandro Mezzani, Bruno Trimarco, Carmine Morisco, Nicola Ferrara, Giuseppe Rengo
OBJECTIVES: To assess pressure injury (PI) incidence among patients hospitalized for acute myocardial infarction (AMI) in an intensive coronary care unit (ICCU) and to detect the impact of specific risk factors on the development of PI in this clinical setting. PATIENTS AND METHODS: Prospective cohort study in ICCU setting. Patients admitted for AMI: patients mean age 67.5±11.5 years (n=165). Norton Scale, Mini Nutritional Assessment (MNA), demographic, clinical and biochemical data collected at the time of ICCU admission have been tested in a logistic model to assess the odds ratios (ORs) of PI risk development...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29027958/adipose-tissue-as-a-strategic-source-of-mesenchymal-stem-cells-in-bone-regeneration-a-topical-review-on-the-most-promising-craniomaxillofacial-applications
#11
REVIEW
Francesco Paduano, Massimo Marrelli, Massimiliano Amantea, Carlo Rengo, Sandro Rengo, Michel Goldberg, Gianrico Spagnuolo, Marco Tatullo
Bone regeneration in craniomaxillofacial surgery represents an issue that involves both surgical and aesthetic aspects. The most recent studies on bone tissue engineering involving adipose-derived stromal/stem cells (ASCs) have clearly demonstrated that such cells can play a crucial role in the treatment of craniomaxillofacial defects, given their strong commitment towards the osteogenic phenotype. A deeper knowledge of the molecular mechanisms underlying ASCs is crucial for a correct understanding of the potentialities of ASCs-based therapies in the most complex maxillofacial applications...
October 13, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28878674/sphingosine-kinases-and-sphingosine-1-phosphate-receptors-signaling-and-actions-in-the-cardiovascular-system
#12
REVIEW
Alessandro Cannavo, Daniela Liccardo, Klara Komici, Graziamaria Corbi, Claudio de Lucia, Grazia D Femminella, Andrea Elia, Leonardo Bencivenga, Nicola Ferrara, Walter J Koch, Nazareno Paolocci, Giuseppe Rengo
The sphingosine kinases 1 and 2 (SphK1 and 2) catalyze the phosphorylation of the lipid, sphingosine, generating the signal transmitter, sphingosine 1-phosphate (S1P). The activation of such kinases and the subsequent S1P generation and secretion in the blood serum of mammals represent a major checkpoint in many cellular signaling cascades. In fact, activating the SphK/S1P system is critical for cell motility and proliferation, cytoskeletal organization, cell growth, survival, and response to stress. In the cardiovascular system, the physiological effects of S1P intervene through the binding and activation of a family of five highly selective G protein-coupled receptors, called S1PR1-5...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28812132/bowel-preparation-in-ct-colonography-is-diet-restriction-necessary-a-randomised-trial-dietsan
#13
Davide Bellini, Domenico De Santis, Damiano Caruso, Marco Rengo, Riccardo Ferrari, Tommaso Biondi, Andrea Laghi
OBJECTIVES: To investigate whether diet restriction affects quality of colon cleansing and patient tolerance during reduced bowel preparation for CT colonography (CTC). METHODS: Asymptomatic and symptomatic patients were enrolled in this pragmatic, single-centre, randomised trial. All patients were randomly assigned (1:1 ratio, blocks of ten) to receive a reduced bowel preparation and faecal tagging with (Diet-Restriction-Group [DR]) or without (No-Diet-Restriction-Group [NDR]) dietary restriction...
January 2018: European Radiology
https://www.readbyqxmd.com/read/28746147/aneurysm-of-vieussens-arterial-ring-in-a-patient-studied-with-coronary-computed-tomography
#14
Carlo N De Cecco, Marco Rengo, Giuseppe Muscogiuri, Damiano Caruso, Davide Bellini, Andrea Laghi
No abstract text is available yet for this article.
September 2017: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/28734651/chromographic-analysis-and-cytotoxic-effects-of-chlorhexidine-and-sodium-hypochlorite-reaction-mixtures
#15
Giuseppina Nocca, Hany Mohamed Aly Ahmed, Giuseppe Ettore Martorana, Cinzia Callà, Gianluca Gambarini, Sandro Rengo, Gianrico Spagnuolo
INTRODUCTION: The literature reveals controversies regarding the formation of para-chloroaniline (PCA) when chlorhexidine (CHX) is mixed with sodium hypochlorite (NaOCl). This study aimed to investigate the stability of PCA in the presence of NaOCl and to examine the in vitro cytotoxic effects of CHX/NaOCl reaction mixtures. METHODS: Different volumes of NaOCl were added to CHX (mix 1) or PCA (mix 2). Upon centrifugation, the supernatant and precipitate fractions collected from samples were analyzed using high-performance liquid chromatography...
July 19, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28683966/%C3%AE-1-blockade-prevents-post-ischemic-myocardial-decompensation-via-%C3%AE-3ar-dependent-protective-sphingosine-1-phosphate-signaling
#16
Alessandro Cannavo, Giuseppe Rengo, Daniela Liccardo, Andres Pun, Ehre Gao, Alvin J George, Giuseppina Gambino, Antonio Rapacciuolo, Dario Leosco, Borja Ibanez, Nicola Ferrara, Nazareno Paolocci, Walter J Koch
BACKGROUND: Although β-blockers increase survival in patients with heart failure (HF), the mechanisms behind this protection are not fully understood, and not all patients with HF respond favorably to them. We recently showed that, in cardiomyocytes, a reciprocal down-regulation occurs between β1-adrenergic receptors (ARs) and the cardioprotective sphingosine-1-phosphate (S1P) receptor-1 (S1PR1). OBJECTIVES: The authors hypothesized that, in addition to salutary actions due to direct β1AR-blockade, agents such as metoprolol (Meto) may improve post-myocardial infarction (MI) structural and functional outcomes via restored S1PR1 signaling, and sought to determine mechanisms accounting for this effect...
July 11, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28671938/cardiac-rehabilitation-participation-rates-and-outcomes-for-patients-with-heart-failure
#17
Jason L Rengo, Patrick D Savage, Trace Barrett, Philip A Ades
PURPOSE: Exercise training has been shown to reduce combined cardiovascular mortality and hospitalizations in patients with chronic heart failure (CHF) with reduced ejection fraction (HFrEF). Whereas there are extensive data on exercise training for individuals with HFrEF in a research setting, the experience of delivering cardiac rehabilitation (CR) services in the clinical setting has not been well described. With little knowledge regarding the number of qualifying patients with HFrEF in the United States, we described our 18-month experience recruiting hospitalized inpatients and stable outpatients into phase 2 CR...
January 2018: Journal of Cardiopulmonary Rehabilitation and Prevention
https://www.readbyqxmd.com/read/28660188/microrna-in-cardiovascular-aging-and-age-related-cardiovascular-diseases
#18
REVIEW
Claudio de Lucia, Klara Komici, Giulia Borghetti, Grazia Daniela Femminella, Leonardo Bencivenga, Alessandro Cannavo, Graziamaria Corbi, Nicola Ferrara, Steven R Houser, Walter J Koch, Giuseppe Rengo
Over the last decades, life expectancy has significantly increased although several chronic diseases persist in the population, with aging as the leading risk factor. Despite improvements in diagnosis and treatment, many elderlies suffer from cardiovascular problems that are much more frequent in an older, more fragile organism. In the long term, age-related cardiovascular diseases (CVDs) contribute to the decline of quality of life and ability to perform normal activities of daily living. microRNAs (miRNAs) are a class of small non-coding RNAs that regulate gene expression at the posttranscriptional level in both physiological and pathological conditions...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/28656154/antidiabetic-drugs-in-alzheimer-s-disease-mechanisms-of-action-and-future-perspectives
#19
REVIEW
Grazia Daniela Femminella, Leonardo Bencivenga, Laura Petraglia, Lucia Visaggi, Lucia Gioia, Fabrizio Vincenzo Grieco, Claudio de Lucia, Klara Komici, Graziamaria Corbi, Paul Edison, Giuseppe Rengo, Nicola Ferrara
Diabetes mellitus (DM) and Alzheimer's disease (AD) are two highly prevalent conditions in the elderly population and major public health burden. In the past decades, a pathophysiological link between DM and AD has emerged and central nervous system insulin resistance might play a significant role as a common mechanism; however, other factors such as inflammation and oxidative stress seem to contribute to the shared pathophysiological link. Both preclinical and clinical studies have evaluated the possible neuroprotective mechanisms of different classes of antidiabetic medications in AD, with some promising results...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28451764/mdct-of-the-liver-in-obese-patients-evaluation-of-a-different-method-to-optimize-iodine-dose
#20
Marco Rengo, Davide Bellini, Rita Businaro, Damiano Caruso, Gabriella Azzara, Domenico De Santis, Simona Picchia, Tommaso Biondi, Marwen Eid, Dario Boschiero, Andrea Laghi
PURPOSE: To prospectively compare two different approaches for estimating the amount of intravenous contrast media (CM) needed for multiphasic MDCT of the liver in obese patients. MATERIALS AND METHODS: This single-center, HIPAA-compliant prospective study was approved by our Institutional Review Board. Ninety-six patients (55 men, 41 women), with a total of 42 hypovascular liver lesions, underwent MDCT of the liver. The amount of contrast medium injected was computed according to the patient's lean body weight which was estimated using either a bioimpedance device (Group A) or the James formula (Group B)...
October 2017: Abdominal Radiology
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