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https://www.readbyqxmd.com/read/28451764/mdct-of-the-liver-in-obese-patients-evaluation-of-a-different-method-to-optimize-iodine-dose
#1
Marco Rengo, Davide Bellini, Rita Businaro, Damiano Caruso, Gabriella Azzara, Domenico De Santis, Simona Picchia, Tommaso Biondi, Marwen Eid, Dario Boschiero, Andrea Laghi
PURPOSE: To prospectively compare two different approaches for estimating the amount of intravenous contrast media (CM) needed for multiphasic MDCT of the liver in obese patients. MATERIALS AND METHODS: This single-center, HIPAA-compliant prospective study was approved by our Institutional Review Board. Ninety-six patients (55 men, 41 women), with a total of 42 hypovascular liver lesions, underwent MDCT of the liver. The amount of contrast medium injected was computed according to the patient's lean body weight which was estimated using either a bioimpedance device (Group A) or the James formula (Group B)...
April 27, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28363512/diffusion-weighted-magnetic-resonance-imaging-in-locally-advanced-rectal-cancer-treated-with-neoadjuvant-chemoradiotherapy
#2
F De Felice, A L Magnante, D Musio, M Ciolina, C N De Cecco, M Rengo, A Laghi, V Tombolini
PURPOSE: To analyze diffusion-weighted magnetic resonance imaging (DW-MRI) for treatment response assessment in locally advanced rectal cancer (LARC). PATIENTS AND METHODS: Patients with histologically proven rectal adenocarcinoma, stage II-III disease, were enrolled and underwent surgery following neoadjuvant chemoradiotherapy (nCRT). All patients were referred for a DW-MRI protocol on a 3 Tesla MR-system, consisting of axial T2-weighted and DWI sequences prior (I), during (II) and after (III) nCRT...
March 23, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28361808/appropriateness-and-efficacy-of-spa-therapy-for-musculoskeletal-disorders-a-delphi-method-consensus-initiative-among-experts-in-italy
#3
Marco Paoloni, Andrea Bernetti, Ovidio Brignoli, Daniela Coclite, Antonio Fraioli, Stefano Masiero, Antonello Napoletano, Nicola Quirino, Franco Rengo, Carlo Ruosi, Ugo Viora, Marco Vitale, Valter Santilli
OBJECTIVE: The aim of the study was to identify the main aspects concerning appropriateness and efficacy of Spa therapy for musculoskeletal pathologies. METHODS: A committee of 8 experts from Italian universities, public hospitals, territorial services, research institutes and patient associations was set up. Clinicians from Italian medical centers specialized in rheumatology, rehabilitation and thermal medicine took part in a Delphi process aimed at obtaining consensus statements among the participants...
January 2017: Annali Dell'Istituto Superiore di Sanità
https://www.readbyqxmd.com/read/28331525/the-anti-ageing-molecule-sirt1-mediates-beneficial-effects-of-cardiac-rehabilitation
#4
Giusy Russomanno, Graziamaria Corbi, Valentina Manzo, Nicola Ferrara, Giuseppe Rengo, Annibale A Puca, Salvatore Latte, Albino Carrizzo, Maria Consiglia Calabrese, Ramaroson Andriantsitohaina, Walter Filippelli, Carmine Vecchione, Amelia Filippelli, Valeria Conti
BACKGROUND: An exercise-based Cardiac Rehabilitation Programme (CRP) is established as adjuvant therapy in heart failure (HF), nevertheless it is underutilized, especially in the elderly. While the functional and hemodynamic effects of CRP are well known, its underlying molecular mechanisms have not been fully clarified. The present study aims to evaluate the effects of a well-structured 4-week CRP in patients with stable HF from a molecular point of view. RESULTS: A prospective longitudinal observational study was conducted on patients consecutively admitted to cardiac rehabilitation...
2017: Immunity & Ageing: I & A
https://www.readbyqxmd.com/read/28306687/directly-measured-physical-function-in-cardiac-rehabilitation
#5
Jason L Rengo, Patrick D Savage, Joan C Shaw, Philip A Ades
PURPOSE: The Short Physical Performance Battery (SPPB) is a strong predictor for risk of physical disability in older adults. Roughly half of individuals participating in phase II cardiac rehabilitation (CR) are 65 years or older, many presenting with low aerobic capacities and may be at increased risk for physical disability. METHODS: The cohort consisted of 196 consecutive patients (136 men), aged 65 years or older, entering CR who were prospectively evaluated by the SPPB...
May 2017: Journal of Cardiopulmonary Rehabilitation and Prevention
https://www.readbyqxmd.com/read/28258739/analysis-of-ct-features-and-quantitative-texture-analysis-in-patients-with-lung-adenocarcinoma-a-correlation-with-egfr-mutations-and-survival-rates
#6
B Sacconi, M Anzidei, A Leonardi, F Boni, L Saba, R Scipione, M Anile, M Rengo, F Longo, M Bezzi, F Venuta, A Napoli, A Laghi, C Catalano
AIM: To investigate the correlation between conventional computed tomography (CT) features, quantitative texture analysis (QTA), epidermal growth factor receptor (EGFR) mutations, and survival rates in patients with lung adenocarcinoma. MATERIALS AND METHODS: Sixty-eight patients were evaluated for conventional CT features and QTA in this retrospective study. A multiple logistic regression analysis and receiver operating characteristics (ROC) curve analysis versus death and EGFR status was performed for CT features and QTA in order to assess correlation between CT features, QTA, EGFR mutations, and survival rates...
February 28, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/28224475/chronic-obstructive-pulmonary-disease-and-long-term-mortality-in-elderly-subjects-with-chronic-heart-failure
#7
Gianluca Testa, Francesco Cacciatore, Andrea Bianco, David Della-Morte, Francesca Mazzella, Gianluigi Galizia, Gaetano Gargiulo, Francesco Curcio, Ilaria Liguori, Alexandra Sabusco, Franco Rengo, Domenico Bonaduce, Pasquale Abete
BACKGROUND: Chronic heart failure (CHF) and chronic obstructive pulmonary disease (COPD) are associated with high rates of mortality in elderly subjects. Concurrent CHF and COPD frequently occur, especially in with advancing age. This study examines long-term mortality in community-dwelling elderly subjects affected by CHF alone, COPD alone, and coexistent CHF and COPD. METHODS: The study evaluated 12-years mortality in 1288 subjects stratified for the presence or absence of CHF or COPD alone, and for coexistence of CHF and COPD...
February 21, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28049968/polyacrylic-resins-regulate-transcriptional-control-of-interleukin-6-gp80-and-gp130-genes-in-human-gingival-fibroblasts
#8
Bruna Borelli, Fernando Zarone, Virginia Rivieccio, Francesco Riccitiello, Michele Simeone, Roberto Sorrentino, Sandro Rengo, Gianrico Spagnuolo, Alfredo Procino
Studies have failed to identify the molecular mechanisms that regulate the genotoxic and cytotoxic effects of methacrylate resins, which are important in the biocompatibility of dental materials. Interleukin (IL)-6 has a crucial role in the control of acute-phase protein response during inflammation. In humans, the synthesis and release of two major acute-phase proteins, C-reactive protein and serum amyloid A, are regulated by IL-6. This study focused on IL-6 and activation of its receptors gp80 and gp130 in human gingival fibroblasts in order to assess the effects of the commercial acid resins Jet Kit, Unifast, and Duralay on control of inflammation...
March 31, 2017: Journal of Oral Science
https://www.readbyqxmd.com/read/28033166/patient-characteristics-predictive-of-cardiac-rehabilitation-adherence
#9
Diann E Gaalema, Patrick D Savage, Jason L Rengo, Alex Y Cutler, Rebecca J Elliott, Jeffrey S Priest, Stephen T Higgins, Philip A Ades
PURPOSE: Cardiac rehabilitation (CR) is a program of structured exercise and interventions for coronary risk factor reduction that reduces morbidity and mortality rates following a major cardiac event. Although a dose-response relationship between the number of CR sessions completed and health outcomes has been demonstrated, adherence with CR is not high. In this study, we examined associations between the number of sessions completed within CR and patient demographics, clinical characteristics, smoking status, and socioeconomic status (SES)...
March 2017: Journal of Cardiopulmonary Rehabilitation and Prevention
https://www.readbyqxmd.com/read/27647163/diagnostic-performance-of-computed-tomography-and-magnetic-resonance-imaging-for-detecting-peritoneal-metastases-systematic-review-and-meta-analysis
#10
REVIEW
Andrea Laghi, Davide Bellini, Marco Rengo, Fabio Accarpio, Damiano Caruso, Daniele Biacchi, Angelo Di Giorgio, Paolo Sammartino
PURPOSE: Primary end point was to assess diagnostic accuracy of computed tomography (CT) and magnetic resonance imaging (MRI) in detecting peritoneal metastases (PM). Secondary end points were determining the diagnostic sensitivity and specificity of CT in detecting PM according to the peritoneal cancer index (PCI), investigating correlations between radiological and surgical PCI, and comparing diagnostic yield of CT versus positron emission tomography (PET)/CT. MATERIALS AND METHODS: We searched MEDLINE, Cochrane Library, Embase and Web of Science databases...
January 2017: La Radiologia Medica
https://www.readbyqxmd.com/read/27631105/erratum-to-comparative-assessment-of-image-quality-for-coronary-ct-angiography-with-iobitridol-and-two-contrast-agents-with-higher-iodine-concentrations-iopromide-and-iomeprol-a-multicentre-randomized-double-blind-trial
#11
Stephan Achenbach, Jean-François Paul, François Laurent, Hans-Christoph Becker, Marco Rengo, Jerome Caudron, Sebastian Leschka, Olivier Vignaux, Gesine Knobloch, Giorgio Benea, Thomas Schlosser, Jordi Andreu, Beatriz Cabeza, Alexis Jacquier, Miguel Souto, Didier Revel, Salah Dine Qanadli, Filippo Cademartiri
No abstract text is available yet for this article.
February 2017: European Radiology
https://www.readbyqxmd.com/read/27340199/sleep-disordered-breathing-impaired-cardiac-adrenergic-innervation-and-prognosis-in-heart-failure
#12
Oriana Scala, Stefania Paolillo, Roberto Formisano, Teresa Pellegrino, Giuseppe Rengo, Paola Gargiulo, Fausto De Michele, Antonio Starace, Antonio Rapacciuolo, Valentina Parisi, Maria Prastaro, Valentina Piscopo, Santo Dellegrottaglie, Dario Bruzzese, Fabiana De Martino, Antonio Parente, Dario Leosco, Bruno Trimarco, Alberto Cuocolo, Pasquale Perrone-Filardi
OBJECTIVE: Unfavourable effects of sleep-disordered breathing (SDB) in heart failure (HF) are mainly mediated by impaired sympathetic activity. Few data are available on SDB and cardiac adrenergic impairment evaluated at myocardial level. The aim of the study was to assess the relationship between SDB, cardiac sympathetic innervation assessed by (123)I-metaiodobenzylguanidine ((123)I-MIBG) imaging and prognosis in HF. METHODS: Observational, prospective study enrolling patients with HF and reduced systolic function...
June 23, 2016: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/27271922/comparative-assessment-of-image-quality-for-coronary-ct-angiography-with-iobitridol-and-two-contrast-agents-with-higher-iodine-concentrations-iopromide-and-iomeprol-a-multicentre-randomized-double-blind-trial
#13
RANDOMIZED CONTROLLED TRIAL
Stephan Achenbach, Jean-François Paul, François Laurent, Hans-Christoph Becker, Marco Rengo, Jerome Caudron, Sebastian Leschka, Olivier Vignaux, Gesine Knobloch, Giorgio Benea, Thomas Schlosser, Jordi Andreu, Beatriz Cabeza, Alexis Jacquier, Miguel Souto, Didier Revel, Salah Dine Qanadli, Filippo Cademartiri
OBJECTIVES: To demonstrate non-inferiority of iobitridol 350 for coronary CT angiography (CTA) compared to higher iodine content contrast media regarding rate of patients evaluable for the presence of coronary artery stenoses. METHODS: In this multicentre trial, 452 patients were randomized to receive iobitridol 350, iopromide 370 or iomeprol 400 and underwent coronary CTA using CT systems with 64-detector rows or more. Two core lab readers assessed 18 coronary segments per patient regarding image quality (score 0 = non diagnostic to 4 = excellent quality), vascular attenuation, signal and contrast to noise ratio (SNR, CNR)...
February 2017: European Radiology
https://www.readbyqxmd.com/read/27254395/effect-of-photon-induced-photoacoustic-streaming-pips-on-bond-strength-to-dentine-of-two-root-canal-filling-materials
#14
Ivana Miletić, Nicoletta Chieffi, Carlo Rengo, Marco Ferrari, Dan Nathanson, Anja Baraba
OBJECTIVES: The aim of this study was to evaluate the effect of photon induced photoacoustic streaming (PIPS) technique in combination with EDTA on bond strength of gutta-percha/AH Plus and Resilon/RealSeal SE root canal fillings to root dentine. MATERIALS AND METHODS: Forty freshly extracted human maxillary anterior teeth with intact straight roots, were instrumented endodontically with rotating ProTaper instruments and randomly divided into two experimental groups...
December 2016: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/27224230/computed-tomography-perfusion-of-prostate-cancer-diagnostic-value-of-quantitative-analysis
#15
Marcello Osimani, Davide Bellini, Antonio Pastore, Giovanni Palleschi, Claudio Di Cristofano, Marco Rengo, Natale Porta, Genoveva Ionela Boboc, Carlo Della Rocca, Antonio Carbone, Vincenzo Petrozza, Andrea Laghi
OBJECTIVE: The aim of the study was to assess the diagnostic value of computed tomography perfusion (CTp) of prostate in distinguishing between normal tissue and malignant lesion by using quantitative threshold values of CTp parameters. MATERIALS AND METHODS: Sixty-one consecutive men with indication for radical prostatectomy were prospectively enrolled. All patients were intravenously injected with 80-mL bolus of nonionic iodinated contrast medium during cine-mode acquisition protocol...
September 2016: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/27189470/adrenergic-drugs-blockers-or-enhancers-for-cognitive-decline-what-to-choose-for-alzheimer-s-disease-patients
#16
Grazia D Femminella, Dario Leosco, Nicola Ferrara, Giuseppe Rengo
The adrenergic system has an important role in normal central nervous system function as well as in brain disease. The locus coeruleus, the main source of norepinephrine in brain, is involved in the regulation of learning and memory, reinforcement of sleep-wake cycle and synaptic plasticity. In Alzheimer's disease, locus coeruleus degeneration is observed early in the course of the disease, years before the onset of clinical cognitive signs, with neurofibrillary detected at the stage of mild cognitive impairment, preceding amyloid deposition...
2016: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/27173155/cognitive-function-and-heart-failure-the-role-of-the-adrenergic-system
#17
Grazia D Femminella, Ciro Candido, Maddalena Conte, Sandra Provenzano, Carlo Rengo, Enrico Coscioni, Nicola Ferrara
BACKGROUND: Heart Failure (HF) and cognitive impairment (CI) represent two high incident diseases worldwide, with extremely elevated mortality and morbidity rates. Their prevalence is expected to further increase in the next years due to the aging population, thus they pose enormous clinical, social and economic challenges. Sympathetic nervous system hyperactivity is known to play a pivotal role in HF pathophysiology and progression. In fact, increased cardiac and circulating catecholamine levels are responsible for several molecular and structural abnormalities with detrimental effects on the failing heart...
2016: Recent Patents on Endocrine, Metabolic & Immune Drug Discovery
https://www.readbyqxmd.com/read/27069636/structure-activity-relationship-study-of-angiotensin-ii-analogs-in-terms-of-%C3%AE-arrestin-dependent-signaling-to-aldosterone-production
#18
Thairy Reyes Valero, Emmanuel Sturchler, Malika Jafferjee, Giuseppe Rengo, Vassiliki Magafa, Paul Cordopatis, Patricia McDonald, Walter J Koch, Anastasios Lymperopoulos
The known angiotensin II (AngII) physiological effect of aldosterone synthesis and secretion induction, a steroid hormone that contributes to the pathology of postmyocardial infarction (MI) heart failure (HF), is mediated by both Gq/11 proteins and β-arrestins, both of which couple to the AngII type 1 receptors (AT1Rs) of adrenocortical zona glomerulosa (AZG) cells. Over the past several years, AngII analogs with increased selectivity ("bias") toward β-arrestin-dependent signaling at the AT1R have been designed and described, starting with SII, the gold-standard β-arrestin-"biased" AngII analog...
April 2016: Pharmacology Research & Perspectives
https://www.readbyqxmd.com/read/27056748/performance-of-diffusion-weighted-imaging-perfusion-imaging-and-texture-analysis-in-predicting-tumoral-response-to-neoadjuvant-chemoradiotherapy-in-rectal-cancer-patients-studied-with-3t-mr-initial-experience
#19
Carlo N De Cecco, Maria Ciolina, Damiano Caruso, Marco Rengo, Balaji Ganeshan, Felix G Meinel, Daniela Musio, Francesca De Felice, Vincenzo Tombolini, Andrea Laghi
PURPOSE: To determine the performance of texture analysis (TA), diffusion-weighted imaging, and perfusion MR (pMRI) in predicting tumoral response in patients treated with neoadjuvant chemoradiotherapy (CRT). METHODS: 12 consecutive patients (8 females, 4 males, 63.2 ± 13.4 years) with rectal cancer were prospectively enrolled, and underwent pre-treatment 3T MRI. Treatment protocol consisted of neoadjuvant CRT with oxaliplatin and 5-fluorouracile. Unenhanced T2-weighted images TA (kurtosis), apparent diffusion coefficient (ADC), and pMRI parameters (Ktrans, Kep, Ve, IAUGC) were quantified by manually delineating a region of interest around the tumor outline...
September 2016: Abdominal Radiology
https://www.readbyqxmd.com/read/26932512/myocardial-pathology-induced-by-aldosterone-is-dependent-on-non-canonical-activities-of-g-protein-coupled-receptor-kinases
#20
Alessandro Cannavo, Daniela Liccardo, Akito Eguchi, Katherine J Elliott, Christopher J Traynham, Jessica Ibetti, Satoru Eguchi, Dario Leosco, Nicola Ferrara, Giuseppe Rengo, Walter J Koch
Hyper-aldosteronism is associated with myocardial dysfunction including induction of cardiac fibrosis and maladaptive hypertrophy. Mechanisms of these cardiotoxicities are not fully understood. Here we show that mineralocorticoid receptor (MR) activation by aldosterone leads to pathological myocardial signalling mediated by mitochondrial G protein-coupled receptor kinase 2 (GRK2) pro-death activity and GRK5 pro-hypertrophic action. Moreover, these MR-dependent GRK2 and GRK5 non-canonical activities appear to involve cross-talk with the angiotensin II type-1 receptor (AT1R)...
March 2, 2016: Nature Communications
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