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Andrea Laghi, Davide Bellini, Marco Rengo, Fabio Accarpio, Damiano Caruso, Daniele Biacchi, Angelo Di Giorgio, Paolo Sammartino
PURPOSE: Primary end point was to assess diagnostic accuracy of computed tomography (CT) and magnetic resonance imaging (MRI) in detecting peritoneal metastases (PM). Secondary end points were determining the diagnostic sensitivity and specificity of CT in detecting PM according to the peritoneal cancer index (PCI), investigating correlations between radiological and surgical PCI, and comparing diagnostic yield of CT versus positron emission tomography (PET)/CT. MATERIALS AND METHODS: We searched MEDLINE, Cochrane Library, Embase and Web of Science databases...
September 19, 2016: La Radiologia Medica
Stephan Achenbach, Jean-François Paul, François Laurent, Hans-Christoph Becker, Marco Rengo, Jerome Caudron, Sebastian Leschka, Olivier Vignaux, Gesine Knobloch, Giorgio Benea, Thomas Schlosser, Jordi Andreu, Beatriz Cabeza, Alexis Jacquier, Miguel Souto, Didier Revel, Salah Dine Qanadli, Filippo Cademartiri
No abstract text is available yet for this article.
September 8, 2016: European Radiology
Oriana Scala, Stefania Paolillo, Roberto Formisano, Teresa Pellegrino, Giuseppe Rengo, Paola Gargiulo, Fausto De Michele, Antonio Starace, Antonio Rapacciuolo, Valentina Parisi, Maria Prastaro, Valentina Piscopo, Santo Dellegrottaglie, Dario Bruzzese, Fabiana De Martino, Antonio Parente, Dario Leosco, Bruno Trimarco, Alberto Cuocolo, Pasquale Perrone-Filardi
OBJECTIVE: Unfavourable effects of sleep-disordered breathing (SDB) in heart failure (HF) are mainly mediated by impaired sympathetic activity. Few data are available on SDB and cardiac adrenergic impairment evaluated at myocardial level. The aim of the study was to assess the relationship between SDB, cardiac sympathetic innervation assessed by (123)I-metaiodobenzylguanidine ((123)I-MIBG) imaging and prognosis in HF. METHODS: Observational, prospective study enrolling patients with HF and reduced systolic function...
June 23, 2016: Heart: Official Journal of the British Cardiac Society
Stephan Achenbach, Jan-François Paul, François Laurent, Hans-Christoph Becker, Marco Rengo, Jerome Caudron, Sebastian Leschka, Olivier Vignaux, Gesine Knobloch, Giorgio Benea, Thomas Schlosser, Jordi Andreu, Beatriz Cabeza, Alexis Jacquier, Miguel Souto, Didier Revel, Salah Dine Qanadli, Filippo Cademartiri
OBJECTIVES: To demonstrate non-inferiority of iobitridol 350 for coronary CT angiography (CTA) compared to higher iodine content contrast media regarding rate of patients evaluable for the presence of coronary artery stenoses. METHODS: In this multicentre trial, 452 patients were randomized to receive iobitridol 350, iopromide 370 or iomeprol 400 and underwent coronary CTA using CT systems with 64-detector rows or more. Two core lab readers assessed 18 coronary segments per patient regarding image quality (score 0 = non diagnostic to 4 = excellent quality), vascular attenuation, signal and contrast to noise ratio (SNR, CNR)...
June 7, 2016: European Radiology
Ivana Miletić, Nicoletta Chieffi, Carlo Rengo, Marco Ferrari, Dan Nathanson, Anja Baraba
OBJECTIVES: The aim of this study was to evaluate the effect of photon induced photoacoustic streaming (PIPS) technique in combination with EDTA on bond strength of gutta-percha/AH Plus and Resilon/RealSeal SE root canal fillings to root dentine. MATERIALS AND METHODS: Forty freshly extracted human maxillary anterior teeth with intact straight roots, were instrumented endodontically with rotating ProTaper instruments and randomly divided into two experimental groups...
June 2, 2016: Lasers in Surgery and Medicine
Marcello Osimani, Davide Bellini, Antonio Pastore, Giovanni Palleschi, Claudio Di Cristofano, Marco Rengo, Natale Porta, Genoveva Ionela Boboc, Carlo Della Rocca, Antonio Carbone, Vincenzo Petrozza, Andrea Laghi
OBJECTIVE: The aim of the study was to assess the diagnostic value of computed tomography perfusion (CTp) of prostate in distinguishing between normal tissue and malignant lesion by using quantitative threshold values of CTp parameters. MATERIALS AND METHODS: Sixty-one consecutive men with indication for radical prostatectomy were prospectively enrolled. All patients were intravenously injected with 80-mL bolus of nonionic iodinated contrast medium during cine-mode acquisition protocol...
September 2016: Journal of Computer Assisted Tomography
Grazia D Femminella, Dario Leosco, Nicola Ferrara, Giuseppe Rengo
The adrenergic system has an important role in normal central nervous system function as well as in brain disease. The locus coeruleus, the main source of norepinephrine in brain, is involved in the regulation of learning and memory, reinforcement of sleep-wake cycle and synaptic plasticity. In Alzheimer's disease, locus coeruleus degeneration is observed early in the course of the disease, years before the onset of clinical cognitive signs, with neurofibrillary detected at the stage of mild cognitive impairment, preceding amyloid deposition...
2016: CNS & Neurological Disorders Drug Targets
Grazia Daniela Femminella, Ciro Candido, Maddalena Conte, Sandra Provenzano, Carlo Rengo, Enrico Coscioni, Nicola Ferrara
BACKGROUND: Heart Failure (HF) and cognitive impairment (CI) represent two high incident diseases worldwide, with extremely elevated mortality and morbidity rates. Their prevalence is expected to further increase in the next years due to the aging population, thus they pose enormous clinical, social and economic challenges. Sympathetic nervous system hyperactivity is known to play a pivotal role in HF pathophysiology and progression. In fact, increased cardiac and circulating catecholamine levels are responsible of several molecular and structural abnormalities with detrimental effects on the failing heart...
May 13, 2016: Recent Patents on Endocrine, Metabolic & Immune Drug Discovery
Thairy Reyes Valero, Emmanuel Sturchler, Malika Jafferjee, Giuseppe Rengo, Vassiliki Magafa, Paul Cordopatis, Patricia McDonald, Walter J Koch, Anastasios Lymperopoulos
The known angiotensin II (AngII) physiological effect of aldosterone synthesis and secretion induction, a steroid hormone that contributes to the pathology of postmyocardial infarction (MI) heart failure (HF), is mediated by both Gq/11 proteins and β-arrestins, both of which couple to the AngII type 1 receptors (AT1Rs) of adrenocortical zona glomerulosa (AZG) cells. Over the past several years, AngII analogs with increased selectivity ("bias") toward β-arrestin-dependent signaling at the AT1R have been designed and described, starting with SII, the gold-standard β-arrestin-"biased" AngII analog...
April 2016: Pharmacology Research & Perspectives
Carlo N De Cecco, Maria Ciolina, Damiano Caruso, Marco Rengo, Balaji Ganeshan, Felix G Meinel, Daniela Musio, Francesca De Felice, Vincenzo Tombolini, Andrea Laghi
PURPOSE: To determine the performance of texture analysis (TA), diffusion-weighted imaging, and perfusion MR (pMRI) in predicting tumoral response in patients treated with neoadjuvant chemoradiotherapy (CRT). METHODS: 12 consecutive patients (8 females, 4 males, 63.2 ± 13.4 years) with rectal cancer were prospectively enrolled, and underwent pre-treatment 3T MRI. Treatment protocol consisted of neoadjuvant CRT with oxaliplatin and 5-fluorouracile. Unenhanced T2-weighted images TA (kurtosis), apparent diffusion coefficient (ADC), and pMRI parameters (Ktrans, Kep, Ve, IAUGC) were quantified by manually delineating a region of interest around the tumor outline...
September 2016: Abdominal Radiology
Alessandro Cannavo, Daniela Liccardo, Akito Eguchi, Katherine J Elliott, Christopher J Traynham, Jessica Ibetti, Satoru Eguchi, Dario Leosco, Nicola Ferrara, Giuseppe Rengo, Walter J Koch
Hyper-aldosteronism is associated with myocardial dysfunction including induction of cardiac fibrosis and maladaptive hypertrophy. Mechanisms of these cardiotoxicities are not fully understood. Here we show that mineralocorticoid receptor (MR) activation by aldosterone leads to pathological myocardial signalling mediated by mitochondrial G protein-coupled receptor kinase 2 (GRK2) pro-death activity and GRK5 pro-hypertrophic action. Moreover, these MR-dependent GRK2 and GRK5 non-canonical activities appear to involve cross-talk with the angiotensin II type-1 receptor (AT1R)...
March 2, 2016: Nature Communications
Valentina Parisi, Giuseppe Rengo, Pasquale Perrone-Filardi, Gennaro Pagano, Grazia Daniela Femminella, Stefania Paolillo, Laura Petraglia, Giuseppina Gambino, Aurelio Caruso, Maria Gabriella Grimaldi, Francesco Baldascino, Maria Nolano, Andrea Elia, Alessandro Cannavo, Antonio De Bellis, Enrico Coscioni, Teresa Pellegrino, Alberto Cuocolo, Nicola Ferrara, Dario Leosco
RATIONALE: It has been reported that epicardial adipose tissue (EAT) may affect myocardial autonomic function. OBJECTIVE: The aim of this study was to explore the relationship between EAT and cardiac sympathetic nerve activity in patients with heart failure. METHODS AND RESULTS: In 110 patients with systolic heart failure, we evaluated the correlation between echocardiographic EAT thickness and cardiac adrenergic nerve activity assessed by (123)I-metaiodobenzylguanidine ((123)I-MIBG)...
April 15, 2016: Circulation Research
Diann E Gaalema, Patrick D Savage, Jason L Rengo, Alexander Y Cutler, Stephen T Higgins, Philip A Ades
PURPOSE: Cardiac rehabilitation (CR) improves medical outcomes after myocardial infarction or coronary revascularization. Lower socioeconomic status (SES) patients are less likely to participate in and complete CR. The aim of this study was to test whether financial incentives may increase participation and adherence to CR among lower-SES patients. METHODS: Patients eligible to participate in CR with Medicaid insurance coverage were approached for inclusion. Patients were placed on an escalating incentive schedule of financial incentives contingent upon CR attendance...
February 15, 2016: Preventive Medicine
Giuseppe Rengo, Gennaro Pagano, Pasquale Perrone Filardi, Grazia Daniela Femminella, Valentina Parisi, Alessandro Cannavo, Daniela Liccardo, Klara Komici, Giuseppina Gambino, Maria Loreta D'Amico, Claudio de Lucia, Stefania Paolillo, Bruno Trimarco, Dino Franco Vitale, Nicola Ferrara, Walter J Koch, Dario Leosco
RATIONALE: Sympathetic nervous system hyperactivity is associated with poor prognosis in patients with heart failure (HF), yet routine assessment of sympathetic nervous system activation is not recommended for clinical practice. Myocardial G protein-coupled receptor kinase-2 (GRK2) is upregulated in HF patients, causing dysfunctional β-adrenergic receptor signaling. Importantly, myocardial GRK2 levels correlate with levels found in peripheral lymphocytes of HF patients. OBJECTIVE: The independent prognostic value of blood GRK2 measurements in HF patients has never been investigated; thus, the purpose of this study was to evaluate whether lymphocyte GRK2 levels predict clinical outcome in HF patients...
April 1, 2016: Circulation Research
Alberto Pilotto, Daniele Sancarlo, Fabio Pellegrini, Franco Rengo, Niccolò Marchionni, Stefano Volpato, Luigi Ferrucci
BACKGROUND: prediction of length of stay (LOS) may be useful to optimise care plans to reduce the negative outcomes related to hospitalisation. OBJECTIVE: to evaluate whether the Multidimensional Prognostic Index (MPI), based on a Comprehensive Geriatric Assessment (CGA), may predict LOS in hospitalised older patients. DESIGN: prospective multicentre cohort study. SETTING: twenty Geriatrics Units. PARTICIPANTS: patients aged 65 and older consecutively admitted to Geriatrics Units...
January 2016: Age and Ageing
Pasquale Paolantonio, Marco Rengo, Riccardo Ferrari, Andrea Laghi
Multidetector CT (MDCT) is an imaging technique that provides otherwise unobtainable information in the diagnostic work-up of patients presenting with acute abdominal pain. A correct working diagnosis depends essentially on understanding the individual patient's clinical data and laboratory findings. In haemodynamically stable patients with acute severe and generalized abdominal pain, MDCT is now the preferred imaging test and gives invaluable diagnostic information, also in unstable patients after stabilization...
2016: British Journal of Radiology
Alessandro Cannavo, Daniela Liccardo, Anastasios Lymperopoulos, Giuseppina Gambino, Maria Loreta D'Amico, Franco Rengo, Walter J Koch, Dario Leosco, Nicola Ferrara, Giuseppe Rengo
After hindlimb ischemia (HI), increased catecholamine levels within the ischemic muscle can cause dysregulation of β2-adrenergic receptor (β2AR) signaling, leading to reduced revascularization. Indeed, in vivo β2AR overexpression via gene therapy enhances angiogenesis in a rat model of HI. G protein-coupled receptor kinase 2 (GRK2) is a key regulator of βAR signaling, and β adrenergic receptor kinase C-terminal peptide (βARKct), a peptide inhibitor of GRK2, has been shown to prevent βAR down-regulation and to protect cardiac myocytes and stem cells from ischemic injury through restoration of β2AR protective signaling (i...
February 2016: Journal of Pharmacology and Experimental Therapeutics
Francesca Pugliese, M G M Hunink, Willem B Meijboom, Katarzyna Gruszczynsnka, Marco Rengo, Lu Zou, Ian Baron, Marcel L Dijkshoorn, Gabriel P Krestin, Pim J de Feyter
To estimate the probability of ≥ 50% coronary stenoses based on computed tomography (CT) segmental calcium score (SCS) and clinical factors. The Institutional Review Board approved the study. A training sample of 201 patients underwent CT calcium scoring and conventional coronary angiography (CCA). All patients consented to undergo CT before CCA after being informed of the additional radiation dose. SCS and calcification morphology were assessed in individual coronary segments. We explored the predictive value of patient's symptoms, clinical history, SCS and calcification morphology...
December 2015: International Journal of Cardiovascular Imaging
Giuseppe Pasqualetti, Gennaro Pagano, Giuseppe Rengo, Nicola Ferrara, Fabio Monzani
BACKGROUND: The association between subclinical hypothyroidism (sHT) and cognitive impairment or risk of dementia is not well-defined, especially in the elderly, where the assessment of central nervous system function is challenging. The aim of this systematic review and meta-analysis was to evaluate the possible effect of sHT on cognitive decline and the risk of dementia. METHODS: Cognitive function was the primary outcome, evaluated as composite endpoint of incidence or prevalence of dementia or difference of Mini Mental State Examination, Wechsler Adult Intelligence Scale, and Wechsler Memory Scale-Revised scores...
November 2015: Journal of Clinical Endocrinology and Metabolism
Lucas L Geyer, U Joseph Schoepf, Felix G Meinel, John W Nance, Gorka Bastarrika, Jonathon A Leipsic, Narinder S Paul, Marco Rengo, Andrea Laghi, Carlo N De Cecco
Owing to recent advances in computing power, iterative reconstruction (IR) algorithms have become a clinically viable option in computed tomographic (CT) imaging. Substantial evidence is accumulating about the advantages of IR algorithms over established analytical methods, such as filtered back projection. IR improves image quality through cyclic image processing. Although all available solutions share the common mechanism of artifact reduction and/or potential for radiation dose savings, chiefly due to image noise suppression, the magnitude of these effects depends on the specific IR algorithm...
August 2015: Radiology
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