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https://www.readbyqxmd.com/read/28878674/sphingosine-kinases-and-sphingosine-1-phosphate-receptors-signaling-and-actions-in-the-cardiovascular-system
#1
REVIEW
Alessandro Cannavo, Daniela Liccardo, Klara Komici, Graziamaria Corbi, Claudio de Lucia, Grazia D Femminella, Andrea Elia, Leonardo Bencivenga, Nicola Ferrara, Walter J Koch, Nazareno Paolocci, Giuseppe Rengo
The sphingosine kinases 1 and 2 (SphK1 and 2) catalyze the phosphorylation of the lipid, sphingosine, generating the signal transmitter, sphingosine 1-phosphate (S1P). The activation of such kinases and the subsequent S1P generation and secretion in the blood serum of mammals represent a major checkpoint in many cellular signaling cascades. In fact, activating the SphK/S1P system is critical for cell motility and proliferation, cytoskeletal organization, cell growth, survival, and response to stress. In the cardiovascular system, the physiological effects of S1P intervene through the binding and activation of a family of five highly selective G protein-coupled receptors, called S1PR1-5...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28812132/bowel-preparation-in-ct-colonography-is-diet-restriction-necessary-a-randomised-trial-dietsan
#2
Davide Bellini, Domenico De Santis, Damiano Caruso, Marco Rengo, Riccardo Ferrari, Tommaso Biondi, Andrea Laghi
OBJECTIVES: To investigate whether diet restriction affects quality of colon cleansing and patient tolerance during reduced bowel preparation for CT colonography (CTC). METHODS: Asymptomatic and symptomatic patients were enrolled in this pragmatic, single-centre, randomised trial. All patients were randomly assigned (1:1 ratio, blocks of ten) to receive a reduced bowel preparation and faecal tagging with (Diet-Restriction-Group [DR]) or without (No-Diet-Restriction-Group [NDR]) dietary restriction...
August 10, 2017: European Radiology
https://www.readbyqxmd.com/read/28746147/aneurysm-of-vieussens-arterial-ring-in-a-patient-studied-with-coronary-computed-tomography
#3
Carlo N De Cecco, Marco Rengo, Giuseppe Muscogiuri, Damiano Caruso, Davide Bellini, Andrea Laghi
No abstract text is available yet for this article.
September 2017: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/28734651/chromographic-analysis-and-cytotoxic-effects-of-chlorhexidine-and-sodium-hypochlorite-reaction-mixtures
#4
Giuseppina Nocca, Hany Mohamed Aly Ahmed, Giuseppe Ettore Martorana, Cinzia Callà, Gianluca Gambarini, Sandro Rengo, Gianrico Spagnuolo
INTRODUCTION: The literature reveals controversies regarding the formation of para-chloroaniline (PCA) when chlorhexidine (CHX) is mixed with sodium hypochlorite (NaOCl). This study aimed to investigate the stability of PCA in the presence of NaOCl and to examine the in vitro cytotoxic effects of CHX/NaOCl reaction mixtures. METHODS: Different volumes of NaOCl were added to CHX (mix 1) or PCA (mix 2). Upon centrifugation, the supernatant and precipitate fractions collected from samples were analyzed using high-performance liquid chromatography...
July 19, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28683966/%C3%AE-1-blockade-prevents-post-ischemic-myocardial-decompensation-via-%C3%AE-3ar-dependent-protective-sphingosine-1-phosphate-signaling
#5
Alessandro Cannavo, Giuseppe Rengo, Daniela Liccardo, Andres Pun, Ehre Gao, Alvin J George, Giuseppina Gambino, Antonio Rapacciuolo, Dario Leosco, Borja Ibanez, Nicola Ferrara, Nazareno Paolocci, Walter J Koch
BACKGROUND: Although β-blockers increase survival in patients with heart failure (HF), the mechanisms behind this protection are not fully understood, and not all patients with HF respond favorably to them. We recently showed that, in cardiomyocytes, a reciprocal down-regulation occurs between β1-adrenergic receptors (ARs) and the cardioprotective sphingosine-1-phosphate (S1P) receptor-1 (S1PR1). OBJECTIVES: The authors hypothesized that, in addition to salutary actions due to direct β1AR-blockade, agents such as metoprolol (Meto) may improve post-myocardial infarction (MI) structural and functional outcomes via restored S1PR1 signaling, and sought to determine mechanisms accounting for this effect...
July 11, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28671938/cardiac-rehabilitation-participation-rates-and-outcomes-for-patients-with-heart-failure
#6
Jason L Rengo, Patrick D Savage, Trace Barrett, Philip A Ades
PURPOSE: Exercise training has been shown to reduce combined cardiovascular mortality and hospitalizations in patients with chronic heart failure (CHF) with reduced ejection fraction (HFrEF). Whereas there are extensive data on exercise training for individuals with HFrEF in a research setting, the experience of delivering cardiac rehabilitation (CR) services in the clinical setting has not been well described. With little knowledge regarding the number of qualifying patients with HFrEF in the United States, we described our 18-month experience recruiting hospitalized inpatients and stable outpatients into phase 2 CR...
June 30, 2017: Journal of Cardiopulmonary Rehabilitation and Prevention
https://www.readbyqxmd.com/read/28660188/microrna-in-cardiovascular-aging-and-age-related-cardiovascular-diseases
#7
REVIEW
Claudio de Lucia, Klara Komici, Giulia Borghetti, Grazia Daniela Femminella, Leonardo Bencivenga, Alessandro Cannavo, Graziamaria Corbi, Nicola Ferrara, Steven R Houser, Walter J Koch, Giuseppe Rengo
Over the last decades, life expectancy has significantly increased although several chronic diseases persist in the population, with aging as the leading risk factor. Despite improvements in diagnosis and treatment, many elderlies suffer from cardiovascular problems that are much more frequent in an older, more fragile organism. In the long term, age-related cardiovascular diseases (CVDs) contribute to the decline of quality of life and ability to perform normal activities of daily living. microRNAs (miRNAs) are a class of small non-coding RNAs that regulate gene expression at the posttranscriptional level in both physiological and pathological conditions...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/28656154/antidiabetic-drugs-in-alzheimer-s-disease-mechanisms-of-action-and-future-perspectives
#8
REVIEW
Grazia Daniela Femminella, Leonardo Bencivenga, Laura Petraglia, Lucia Visaggi, Lucia Gioia, Fabrizio Vincenzo Grieco, Claudio de Lucia, Klara Komici, Graziamaria Corbi, Paul Edison, Giuseppe Rengo, Nicola Ferrara
Diabetes mellitus (DM) and Alzheimer's disease (AD) are two highly prevalent conditions in the elderly population and major public health burden. In the past decades, a pathophysiological link between DM and AD has emerged and central nervous system insulin resistance might play a significant role as a common mechanism; however, other factors such as inflammation and oxidative stress seem to contribute to the shared pathophysiological link. Both preclinical and clinical studies have evaluated the possible neuroprotective mechanisms of different classes of antidiabetic medications in AD, with some promising results...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28451764/mdct-of-the-liver-in-obese-patients-evaluation-of-a-different-method-to-optimize-iodine-dose
#9
Marco Rengo, Davide Bellini, Rita Businaro, Damiano Caruso, Gabriella Azzara, Domenico De Santis, Simona Picchia, Tommaso Biondi, Marwen Eid, Dario Boschiero, Andrea Laghi
PURPOSE: To prospectively compare two different approaches for estimating the amount of intravenous contrast media (CM) needed for multiphasic MDCT of the liver in obese patients. MATERIALS AND METHODS: This single-center, HIPAA-compliant prospective study was approved by our Institutional Review Board. Ninety-six patients (55 men, 41 women), with a total of 42 hypovascular liver lesions, underwent MDCT of the liver. The amount of contrast medium injected was computed according to the patient's lean body weight which was estimated using either a bioimpedance device (Group A) or the James formula (Group B)...
April 27, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28363512/diffusion-weighted-magnetic-resonance-imaging-in-locally-advanced-rectal-cancer-treated-with-neoadjuvant-chemoradiotherapy
#10
F De Felice, A L Magnante, D Musio, M Ciolina, C N De Cecco, M Rengo, A Laghi, V Tombolini
PURPOSE: To analyze diffusion-weighted magnetic resonance imaging (DW-MRI) for treatment response assessment in locally advanced rectal cancer (LARC). PATIENTS AND METHODS: Patients with histologically proven rectal adenocarcinoma, stage II-III disease, were enrolled and underwent surgery following neoadjuvant chemoradiotherapy (nCRT). All patients were referred for a DW-MRI protocol on a 3 Tesla MR-system, consisting of axial T2-weighted and DWI sequences prior (I), during (II) and after (III) nCRT...
July 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28361808/appropriateness-and-efficacy-of-spa-therapy-for-musculoskeletal-disorders-a-delphi-method-consensus-initiative-among-experts-in-italy
#11
Marco Paoloni, Andrea Bernetti, Ovidio Brignoli, Daniela Coclite, Antonio Fraioli, Stefano Masiero, Antonello Napoletano, Nicola Quirino, Franco Rengo, Carlo Ruosi, Ugo Viora, Marco Vitale, Valter Santilli
OBJECTIVE: The aim of the study was to identify the main aspects concerning appropriateness and efficacy of Spa therapy for musculoskeletal pathologies. METHODS: A committee of 8 experts from Italian universities, public hospitals, territorial services, research institutes and patient associations was set up. Clinicians from Italian medical centers specialized in rheumatology, rehabilitation and thermal medicine took part in a Delphi process aimed at obtaining consensus statements among the participants...
January 2017: Annali Dell'Istituto Superiore di Sanità
https://www.readbyqxmd.com/read/28331525/the-anti-ageing-molecule-sirt1-mediates-beneficial-effects-of-cardiac-rehabilitation
#12
Giusy Russomanno, Graziamaria Corbi, Valentina Manzo, Nicola Ferrara, Giuseppe Rengo, Annibale A Puca, Salvatore Latte, Albino Carrizzo, Maria Consiglia Calabrese, Ramaroson Andriantsitohaina, Walter Filippelli, Carmine Vecchione, Amelia Filippelli, Valeria Conti
BACKGROUND: An exercise-based Cardiac Rehabilitation Programme (CRP) is established as adjuvant therapy in heart failure (HF), nevertheless it is underutilized, especially in the elderly. While the functional and hemodynamic effects of CRP are well known, its underlying molecular mechanisms have not been fully clarified. The present study aims to evaluate the effects of a well-structured 4-week CRP in patients with stable HF from a molecular point of view. RESULTS: A prospective longitudinal observational study was conducted on patients consecutively admitted to cardiac rehabilitation...
2017: Immunity & Ageing: I & A
https://www.readbyqxmd.com/read/28306687/directly-measured-physical-function-in-cardiac-rehabilitation
#13
Jason L Rengo, Patrick D Savage, Joan C Shaw, Philip A Ades
PURPOSE: The Short Physical Performance Battery (SPPB) is a strong predictor for risk of physical disability in older adults. Roughly half of individuals participating in phase II cardiac rehabilitation (CR) are 65 years or older, many presenting with low aerobic capacities and may be at increased risk for physical disability. METHODS: The cohort consisted of 196 consecutive patients (136 men), aged 65 years or older, entering CR who were prospectively evaluated by the SPPB...
May 2017: Journal of Cardiopulmonary Rehabilitation and Prevention
https://www.readbyqxmd.com/read/28258739/analysis-of-ct-features-and-quantitative-texture-analysis-in-patients-with-lung-adenocarcinoma-a-correlation-with-egfr-mutations-and-survival-rates
#14
B Sacconi, M Anzidei, A Leonardi, F Boni, L Saba, R Scipione, M Anile, M Rengo, F Longo, M Bezzi, F Venuta, A Napoli, A Laghi, C Catalano
AIM: To investigate the correlation between conventional computed tomography (CT) features, quantitative texture analysis (QTA), epidermal growth factor receptor (EGFR) mutations, and survival rates in patients with lung adenocarcinoma. MATERIALS AND METHODS: Sixty-eight patients were evaluated for conventional CT features and QTA in this retrospective study. A multiple logistic regression analysis and receiver operating characteristics (ROC) curve analysis versus death and EGFR status was performed for CT features and QTA in order to assess correlation between CT features, QTA, EGFR mutations, and survival rates...
June 2017: Clinical Radiology
https://www.readbyqxmd.com/read/28224475/chronic-obstructive-pulmonary-disease-and-long-term-mortality-in-elderly-subjects-with-chronic-heart-failure
#15
Gianluca Testa, Francesco Cacciatore, Andrea Bianco, David Della-Morte, Francesca Mazzella, Gianluigi Galizia, Gaetano Gargiulo, Francesco Curcio, Ilaria Liguori, Alexandra Sabusco, Franco Rengo, Domenico Bonaduce, Pasquale Abete
BACKGROUND: Chronic heart failure (CHF) and chronic obstructive pulmonary disease (COPD) are associated with high rates of mortality in elderly subjects. Concurrent CHF and COPD frequently occur, especially in with advancing age. This study examines long-term mortality in community-dwelling elderly subjects affected by CHF alone, COPD alone, and coexistent CHF and COPD. METHODS: The study evaluated 12-years mortality in 1288 subjects stratified for the presence or absence of CHF or COPD alone, and for coexistence of CHF and COPD...
February 21, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28049968/polyacrylic-resins-regulate-transcriptional-control-of-interleukin-6-gp80-and-gp130-genes-in-human-gingival-fibroblasts
#16
Bruna Borelli, Fernando Zarone, Virginia Rivieccio, Francesco Riccitiello, Michele Simeone, Roberto Sorrentino, Sandro Rengo, Gianrico Spagnuolo, Alfredo Procino
Studies have failed to identify the molecular mechanisms that regulate the genotoxic and cytotoxic effects of methacrylate resins, which are important in the biocompatibility of dental materials. Interleukin (IL)-6 has a crucial role in the control of acute-phase protein response during inflammation. In humans, the synthesis and release of two major acute-phase proteins, C-reactive protein and serum amyloid A, are regulated by IL-6. This study focused on IL-6 and activation of its receptors gp80 and gp130 in human gingival fibroblasts in order to assess the effects of the commercial acid resins Jet Kit, Unifast, and Duralay on control of inflammation...
March 31, 2017: Journal of Oral Science
https://www.readbyqxmd.com/read/28033166/patient-characteristics-predictive-of-cardiac-rehabilitation-adherence
#17
Diann E Gaalema, Patrick D Savage, Jason L Rengo, Alex Y Cutler, Rebecca J Elliott, Jeffrey S Priest, Stephen T Higgins, Philip A Ades
PURPOSE: Cardiac rehabilitation (CR) is a program of structured exercise and interventions for coronary risk factor reduction that reduces morbidity and mortality rates following a major cardiac event. Although a dose-response relationship between the number of CR sessions completed and health outcomes has been demonstrated, adherence with CR is not high. In this study, we examined associations between the number of sessions completed within CR and patient demographics, clinical characteristics, smoking status, and socioeconomic status (SES)...
March 2017: Journal of Cardiopulmonary Rehabilitation and Prevention
https://www.readbyqxmd.com/read/27647163/diagnostic-performance-of-computed-tomography-and-magnetic-resonance-imaging-for-detecting-peritoneal-metastases-systematic-review-and-meta-analysis
#18
REVIEW
Andrea Laghi, Davide Bellini, Marco Rengo, Fabio Accarpio, Damiano Caruso, Daniele Biacchi, Angelo Di Giorgio, Paolo Sammartino
PURPOSE: Primary end point was to assess diagnostic accuracy of computed tomography (CT) and magnetic resonance imaging (MRI) in detecting peritoneal metastases (PM). Secondary end points were determining the diagnostic sensitivity and specificity of CT in detecting PM according to the peritoneal cancer index (PCI), investigating correlations between radiological and surgical PCI, and comparing diagnostic yield of CT versus positron emission tomography (PET)/CT. MATERIALS AND METHODS: We searched MEDLINE, Cochrane Library, Embase and Web of Science databases...
January 2017: La Radiologia Medica
https://www.readbyqxmd.com/read/27631105/erratum-to-comparative-assessment-of-image-quality-for-coronary-ct-angiography-with-iobitridol-and-two-contrast-agents-with-higher-iodine-concentrations-iopromide-and-iomeprol-a-multicentre-randomized-double-blind-trial
#19
Stephan Achenbach, Jean-François Paul, François Laurent, Hans-Christoph Becker, Marco Rengo, Jerome Caudron, Sebastian Leschka, Olivier Vignaux, Gesine Knobloch, Giorgio Benea, Thomas Schlosser, Jordi Andreu, Beatriz Cabeza, Alexis Jacquier, Miguel Souto, Didier Revel, Salah Dine Qanadli, Filippo Cademartiri
No abstract text is available yet for this article.
February 2017: European Radiology
https://www.readbyqxmd.com/read/27340199/sleep-disordered-breathing-impaired-cardiac-adrenergic-innervation-and-prognosis-in-heart-failure
#20
Oriana Scala, Stefania Paolillo, Roberto Formisano, Teresa Pellegrino, Giuseppe Rengo, Paola Gargiulo, Fausto De Michele, Antonio Starace, Antonio Rapacciuolo, Valentina Parisi, Maria Prastaro, Valentina Piscopo, Santo Dellegrottaglie, Dario Bruzzese, Fabiana De Martino, Antonio Parente, Dario Leosco, Bruno Trimarco, Alberto Cuocolo, Pasquale Perrone-Filardi
OBJECTIVE: Unfavourable effects of sleep-disordered breathing (SDB) in heart failure (HF) are mainly mediated by impaired sympathetic activity. Few data are available on SDB and cardiac adrenergic impairment evaluated at myocardial level. The aim of the study was to assess the relationship between SDB, cardiac sympathetic innervation assessed by (123)I-metaiodobenzylguanidine ((123)I-MIBG) imaging and prognosis in HF. METHODS: Observational, prospective study enrolling patients with HF and reduced systolic function...
June 23, 2016: Heart: Official Journal of the British Cardiac Society
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