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Choroid And Quantitative

Xiaochun Zhao, Leandro Borba Moreira, Claudio Cavallo, Evgenii Belykh, Sirin Gandhi, Mohamed A Labib, Ali Tayebi Meybodi, Celene B Mulholland, Brandon D Liebelt, Michaela Lee, Peter Nakaji, Mark C Preul
OBJECTIVE: The contralateral interhemispheric transprecuneus approach (CITP) and the supracerebellar transtentorial transcollateral sulcus approach (STTC) are two novel approaches to access the atrium of the lateral ventricle. The authors quantitatively compared the two approaches. METHODS: Both approaches were performed in 6 sides of fixed and color-injected cadaver heads. We predefined 6 targets in the atrium for measurement and standardization of the approaches...
October 8, 2018: World Neurosurgery
Florence Coscas, Diogo Cabral, Telmo Pereira, Carlos Geraldes, Hemaxi Narotamo, Alexandra Miere, Marco Lupidi, Alexandre Sellam, Ana Papoila, Gabriel Coscas, Eric Souied
PURPOSE: To characterize quantitative optical coherence tomography angiography (OCT-A) parameters in active neovascular age-related macular degeneration (nAMD) patients under treatment and remission nAMD patients. DESIGN: Retrospective, cross-sectional study. PARTICIPANTS: One hundred and four patients of whom 72 were in Group 1 (active nAMD) and 32 in Group 2 (remission nAMD) based on SD-OCT (Spectral Domain OCT) qualitative morphology. METHODS: This study was conducted at the Centre Ophtalmologique de l'Odeon between June 2016 and December 2017...
2018: PloS One
Jiwon Baek, Jae Hyung Lee, Byung Joo Jung, Lee Kook, Won Ki Lee
PURPOSE: To compare choroidal vascular characteristics of age-related macular degeneration (AMD), polypoidal choroidal vasculopathy (PCV), and central serous chorioretinopathy (CSC) by qualitative and quantitative analyses using swept-source en face optical coherence tomographic (OCT) images. METHODS: Eyes with non-neovascular AMD (n = 32), neovascular AMD (n = 30), thick and thin choroid PCV (n = 33 and 27), and CSC (n = 34) were enrolled. Subfoveal choroidal thickness (SFCT) and the presence and patterns of pachyvessels were assessed...
September 27, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
Akari Takita, Yuki Hashimoto, Wataru Saito, Satoru Kase, Susumu Ishida
Purpose: Choroidal circulation hemodynamics in eyes with leukemia has not been quantitatively examined yet. We quantitatively examined changes in choroidal blood flow velocity and choroidal thickness at the macula by using laser speckle flowgraphy (LSFG) and enhanced depth imaging optical coherence tomography (EDI-OCT) in a patient with leukemic retinopathy. Observations: A 15-year-old boy presented with sudden central vision loss of his right eye. The patient's best-corrected visual acuity was 0...
December 2018: American Journal of Ophthalmology Case Reports
Safal Khanal, Philip R K Turnbull, Ehsan Vaghefi, John R Phillips
BACKGROUND: Quantifying blood perfusion in ocular tissues is challenging, partly because the majority of the blood is carried by the choroid, which is difficult to visualize because it is located between the retina and sclera. PURPOSE/HYPOTHESIS: To evaluate the intra- and interday repeatability of MRI measures of chorio-retinal blood perfusion. STUDY TYPE: Prospective, cross-sectional, observational study. POPULATION: Twenty young healthy adults (six male, age: 25 ± 5 years) scanned twice within a single session repeated at the same time of day on 2 days...
September 25, 2018: Journal of Magnetic Resonance Imaging: JMRI
Scott M McClintic, Simon Gao, Jie Wang, Ahmed Hagag, Andreas K Lauer, Christina J Flaxel, Kavita Bhavsar, Thomas S Hwang, David Huang, Yali Jia, Steven T Bailey
Purpose: To use optical coherence tomography angiography (OCTA) derived quantitative metrics to assess the response of choroidal neovascularization to pro-re-nata (PRN) anti-endothelial growth factor (anti-VEGF) treatment in neovascular age-related macular degeneration (AMD). Design: Prospective longitudinal cohort study. Participants: Fourteen eyes from 14 study participants with treatment-naïve neovascular AMD were enrolled. Methods: Subjects were evaluated monthly and treated with intravitreal anti-VEGF agents under a PRN protocol for one year...
September 2018: Ophthalmology Retina
Seyedmehdi Payabvash, Tarik Tihan, Soonmee Cha
Purpose We applied voxelwise apparent diffusion coefficient (ADC) histogram analysis in addition to structural magnetic resonance imaging (MRI) findings and patients' age for differentiation of intraaxial posterior fossa tumors involving the fourth ventricle. Participants and methods Pretreatment MRIs of 74 patients with intraaxial brain neoplasm involving the fourth ventricle, from January 1, 2004 to December 31, 2015, were reviewed. The tumor solid components were segmented and voxelwise ADC histogram variables were determined...
September 19, 2018: Neuroradiology Journal
Gaoqin Liu, Lei Chen, Qinhua Cai, Hongya Wu, Zhigang Chen, Xueguang Zhang, Peirong Lu
The present study aimed to investigate the effects of diabetes mellitus (DM) on the generation of experimental corneal neovascularization (CrNV) and choroidal neovascularization (ChNV). Diabetes was induced in mice by intraperitoneal injection of streptozotocin (STZ). Experimental CrNV and ChNV were induced by alkali injury and laser photocoagulation, respectively. CrNV and ChNV were compared between the STZ‑induced diabetic mice and control mice two weeks after injury. Relative expression of angiogenic factors was quantified by reverse transcription‑quantitative polymerase chain reaction, and progenitor cell or macrophage accumulation in the early phase following injury was examined by flow cytometric analysis...
September 3, 2018: Molecular Medicine Reports
Ruben Jauregui, Karen Sophia Park, Jimmy K Duong, Vinit B Mahajan, Stephen H Tsang
Optical coherence tomography angiography (OCT-A) is a non-invasive alternative to fluorescein angiography that allows for the study of the retinal and choroidal vasculatures. In this retrospective cohort study of 28 patients with retinitis pigmentosa (RP), we used OCT-A to quantify changes in perfusion density, foveal avascular zone (FAZ) area, and choriocapillaris blood flow over time and correlated these variables with ellipsoid zone (EZ) line width and best-corrected visual acuity (BCVA). Perfusion density decreased by 2...
September 3, 2018: Scientific Reports
Kaivon Pakzad-Vaezi, Kosar Khaksari, Zhongdi Chu, Russell N Van Gelder, Ruikang K Wang, Kathryn L Pepple
Purpose: To examine and quantify choriocapillaris lesions in active and quiescent serpiginous choroiditis (SC) using swept-source optical coherence tomography angiography (SS-OCTA) and en-face image analysis. Design: Prospective observational case series. Participants: Patients with a clinical diagnosis of SC. Methods: A SS-OCTA prototype was used to image active and quiescent serpiginous lesions longitudinally before and after anti-inflammatory treatment...
July 2018: Ophthalmology Retina
Philipp L Müller, Maximilian Pfau, Philipp T Möller, Jennifer Nadal, Matthias Schmid, Moritz Lindner, Luis de Sisternes, Heidi Stöhr, Bernhard H F Weber, Christine Neuhaus, Philipp Herrmann, Steffen Schmitz-Valckenberg, Frank G Holz, Monika Fleckenstein
Purpose: To investigate the choroidal blood flow in areas within and adjacent to retinal pigment epithelium (RPE) atrophy secondary to late-onset Stargardt disease (STGD1) and age-related macular degeneration (AMD). Methods: A total of 43 eyes (23 STGD1 and 20 AMD) of patients with RPE atrophy and 25 eyes of healthy controls without ocular pathology underwent multimodal imaging including optical coherence tomography angiography (OCT-A; PLEX Elite 9000 Swept-Source OCT)...
March 20, 2018: Investigative Ophthalmology & Visual Science
Rebecca J Kapphahn, Michael J Richards, Deborah A Ferrington, Steven J Fliesler
Oxidative modification of proteins can perturb their structure and function, often compromising cellular viability. Such modifications include lipid-derived adducts (e.g., 4-hydroxynonenal (HNE) and carboxyethylpyrrole (CEP)) as well as nitrotyrosine (NTyr). We compared the retinal proteome and levels of such modifications in the AY9944-treated rat model of Smith-Lemli-Opitz syndrome (SLOS), in comparison to age-matched controls. Retinas harvested at 3 months of age were either subjected to proteomic analysis or to immuno-slot blot analysis, the latter probing blots with antibodies raised against HNE, CEP, and NTyr, followed by quantitative densitometry...
August 14, 2018: Experimental Eye Research
Mirinae Kim, Seung Yong Choi, Young-Hoon Park
The relationship between choroidal and retinal microvascular changes has not yet been well described, and there were limited data on diagnostic ability of optical coherence tomography (OCT)-derived vascular parameters for determining diabetic retinopathy (DR) progression. We quantitatively analyzed OCT-derived vascular parameters at superficial (SCP) and deep retinal capillary plexus (DCP), and choroid. We assessed foveal avascular zone (FAZ), vessel density, vessel length density, and choroidal vascularity index in conjunction with DR stage...
August 14, 2018: Scientific Reports
Manas R Biswal, Howard M Prentice, George W Smith, Ping Zhu, Yao Tong, C Kathleen Dorey, Alfred S Lewin, Janet C Blanks
Aberrant growth of blood vessels in the choroid layer of the eye, termed choroidal neovascularization (CNV), is the pathological hallmark of exudative age-related macular degeneration (AMD), causing irreversible blindness among the elderly. Co-localization of proangiogenic factors and hypoxia inducible factors (HIF) in neovascular membranes from AMD eyes suggests the role of hypoxia in pathogenesis of CNV. In order to utilize hypoxic conditions in RPE for therapeutic purposes, we developed an optimized hypoxia regulated, RPE cell-specific gene therapy to inhibit choroidal neovascularization...
October 2018: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
Alessandro Arrigo, Emanuela Aragona, Luigi Capone, Luisa Pierro, Francesco Romano, Francesco Bandello, Maurizio Battaglia Parodi
PURPOSE: To analyze optical coherence tomography angiography (OCTA) quantitative features in patients affected by new-onset choroidal neovascularization (CNV) in one eye and early/intermediate age-related macular degeneration (AMD) in the fellow eye. DESIGN: Case-control study. SETTINGS: Clinical Practice. STUDY POPULATION: Thirty patients and thirty age-matched controls. OBSERVATION PROCEDURES: Both cohorts underwent complete ophthalmologic examination, including best corrected visual acuity (BCVA) measurement, biomicroscopy, fluorescein angiography (FA) and indocyanine green angiography (ICGA) examination (Spectralis HRA; Heidelberg Engineering, Germany), OCT and OCTA scans (DRI OCT Triton; Topcon Corporation, Japan)...
August 8, 2018: American Journal of Ophthalmology
Yongjoo Kim, Hye Kyoung Hong, Jang Ryul Park, WooJhon Choi, Se Joon Woo, Kyu Hyung Park, Wang-Yuhl Oh
Purpose: The purpose of this study was to assess the retinal and choroidal vasculatures of an oxygen-induced retinopathy (OIR) rat model using optical coherence tomography angiography (OCTA) as well as to verify the performance of OCTA for visualizing in vivo vascular alterations, longitudinally and quantitatively. Methods: To induce OIR, Sprague Dawley rat pups were incubated in an 80% oxygen chamber from postnatal day 1 (P1) to P11 and returned to room air. OCTA imaging was performed in six eyes at P15, P18, P21, and P24...
August 1, 2018: Investigative Ophthalmology & Visual Science
Patrick Vancura, Erika Csicsely, Annalisa Leiser, P Michael Iuvone, Rainer Spessert
Purpose: The aim of the present study was to identify candidate genes for mediating daily adjustment of vision. Methods: Genes important for vision and genetically associated with severe retinal diseases were tested for 24-hour rhythms in transcript levels in neuronal retina, microdissected photoreceptors, photoreceptor-related pinealocytes, and retinal pigment epithelium-choroid (RPE-choroid) complex by using quantitative PCR. Results: Photoreceptors of wildtype mice display circadian clock-dependent regulation of visual arrestins (Arr1, Arr4) and the visual cycle gene Rdh12, whereas cells of the RPE-choroid exhibit light-dependent regulation of the visual cycle key genes Lrat, Rpe65, and Rdh5...
August 1, 2018: Investigative Ophthalmology & Visual Science
Juha Song, Kihwang Lee, Sung Wook Park, Hyewon Chung, Daun Jung, Yi Rang Na, Hailian Quan, Chang Sik Cho, Jeong-Hwan Che, Jeong Hun Kim, Jae-Hak Park, Seung Hyeok Seok
Purpose: Lactic acid, the end product of glycolysis, has emerged as an immune-modulating metabolite in various diseases. In this study, we aimed to examine whether lactic acid contributes to the disease pathogenesis of choroidal neovascularization (CNV) and to investigate the role of macrophages in CNV pathogenesis. Methods: CNV was induced by laser photocoagulation in C57BL/6J mice. Lactic acid concentration was measured in the RPE-choroid region. Macrophage infiltration and VEGF were quantified by flow cytometry...
July 2, 2018: Investigative Ophthalmology & Visual Science
Brijesh Takkar, Nripen Gaur, Hameed Obedulla, Ramesh Chand Chauhan, Shreyas Temkar, Pradeep Venkatesh, Rohan Chawla, Atul Kumar
Purpose: To evaluate the interobserver variation in the assessment of retinal length to choroidal length ratio (RCR) as a marker for proliferative vitreoretinopathy (PVR) in cases of rhegmatogenous retinal detachment (RRD). Methods: This was a double-masked, prospective study at a tertiary center. Ultrasound was used to calculate RCR in 50 eyes with total RRD by two observers. Both observers were trained after the first round of calculations, and all the calculations were repeated as before...
August 2018: Indian Journal of Ophthalmology
Marco Nassisi, Wenying Fan, Yue Shi, Jianqin Lei, Enrico Borrelli, Michael Ip, Srinivas R Sadda
Purpose: The purpose of this study was to evaluate the correlation between quantity of intraretinal hyperreflective foci (HRF) in the eye with intermediate AMD and progression to late AMD. Methods: Volume optical coherence tomography (OCT) scans from 114 eyes of 114 patients were retrospectively reviewed. HRF were assessed both qualitatively and quantitatively. Five sequential en face slabs from midretina were thresholded to isolate the HRF. These five slabs were recombined, and HRF area was measured in the whole 6 × 6-mm image (HRFTOT) and within the central 3-mm (HRF3mm) and 5-mm (HRF5mm) regions...
July 2, 2018: Investigative Ophthalmology & Visual Science
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