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Choroid And Quantitative

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https://www.readbyqxmd.com/read/30550530/quantification-of-choroidal-vasculature-by-high-quality-structure-en-face-swept-source-optical-coherence-tomography-images-in-eyes-with-central-serous-chorioretinopathy
#1
Yuki Ogawa, Ichiro Maruko, Hideki Koizumi, Tomohiro Iida
PURPOSE: To determine the density of the choroidal vasculature by high-quality structure en face optical coherence tomography (OCT) scanned at the same time as OCT angiography in eyes with central serous chorioretinopathy (CSC). METHODS: Thirty-five eyes of 30 patients with CSC (20 men and 10 women; average age, 48.4 years) were studied. Volume scans (12 × 12 mm-square) were obtained at the same time as OCT angiographic scans (Plex Elite 9000; Swept-Source OCT, Zeiss)...
December 13, 2018: Retina
https://www.readbyqxmd.com/read/30541290/pachychoroid-disease-of-the-macula
#2
A Stepanov, J Studnička, M Středová, N Jirásková
Progress in optical coherent tomography (OCT) has recently provided new insights into variety of chorioretinal disorders. The use of EDI (Enhanced Depth Imaging) during OCT examinations and as well as OCT angiography provides a more accurate analysis of the choroid both quantitatively and qualitatively. "Pachychoroid" (greek pachy- [παχύ] - thick) is defined as an abnormal and sustained increase in choroidal thickness 300 μm, which is mainly due to dilated choroidal vessels in the Hallers layer and other structural changes in physiological choroidal architecture...
2018: Ceská a Slovenská Oftalmologie
https://www.readbyqxmd.com/read/30533267/combination-of-the-tubular-retractor-and-brain-spatulas-provides-an-adequate-operative-field-in-surgery-for-deep-seated-lesions-case-series-and-technical-note
#3
Yoshihiro Otani, Kazuhiko Kurozumi, Joji Ishida, Masafumi Hiramatsu, Masahiro Kameda, Tomotsugu Ichikawa, Isao Date
Background: Surgeries for deep-seated lesions are challenging because making a corridor and observing the interface between lesions and normal brain tissue are difficult. The ViewSite Brain Access System, which is a clear plastic tubular retractor system, is used for resection of deep-seated lesions. However, the tapered shape of this system may result in limitation of the surgical field and cause brain injury to observe the interface between lesions and normal tissue. In this study, we evaluated the usefulness of the combination of ViewSite and brain spatulas...
2018: Surgical Neurology International
https://www.readbyqxmd.com/read/30496750/choroidal-imaging-biomarkers
#4
REVIEW
Sumit Randhir Singh, Kiran Kumar Vupparaboina, Abhilash Goud, Kunal K Dansingani, Jay Chhablani
The choroid is the vascular coat of the eye,and its role has been studied in multiple chorioretinal disorders. The recent advancements in choroidal imaging techniques including enhanced depth imaging optical coherence tomography (EDI-OCT), swept source (SS-OCT), enface OCT and OCT angiography have facilitated an in-depth analysis of choroid. The gradual shift from manual to automated segmentation and binarization methods have led to precise and reproducible measurements of choroidal parameters. These qualitative and quantitative parameters, called choroidal imaging biomarkers, have evolved over the past decade from a simple linear subfoveal choroidal thickness to more complex 3 dimensional (3-D) choroidal reconstruction thus widening the spectrum encompassing multiple parameters...
November 26, 2018: Survey of Ophthalmology
https://www.readbyqxmd.com/read/30479712/comparison-of-retinal-and-choroidal-involvement-in-sarcoidosis-related-chorioretinitis-using-fluorescein-and-indocyanine-green-angiography
#5
Ala'a El Ameen, Carl P Herbort
Purpose: To compare the involvement of the retina with that of the choroid in ocular sarcoidosis (OS) using dual fluorescein angiography (FA)/indocyanine green angiography (ICGA). Methods: A retrospective study of 23 patients with the diagnosis of OS was performed. Angiographic signs were quantified following the established FA/ICGA scoring system for uveitis. Results: The choroid was predominantly involved in 19 (82.6%) patients or 87% (40/46) of the eyes, and the retina in 2 (8...
October 2018: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/30460869/optical-coherence-tomography-angiography-octa-flow-speed-mapping-technology-for-retinal-diseases
#6
Malvika Arya, Ramy Rashad, Osama Sorour, Eric M Moult, James G Fujimoto, Nadia K Waheed
Optical coherence tomography angiography (OCTA) is a noninvasive imaging modality for depth-resolved visualization of retinal vasculature. Angiographic data couples with structural data to generate a cube scan, from which en-face images of vasculature can be obtained at various axial positions. OCTA has expanded understanding of retinal vascular disorders and has primarily been used for qualitative analysis. Areas Covered: Recent studies have explored the quantitative properties of OCTA, which would allow for objective assessment and follow-up of retinal pathologies...
November 21, 2018: Expert Review of Medical Devices
https://www.readbyqxmd.com/read/30338161/non-mydriatic-chorioretinal-imaging-in-a-transmission-geometry-and-application-to-retinal-oximetry
#7
Timothy D Weber, Jerome Mertz
The human retina is typically imaged in a reflection geometry, where light is delivered through the pupil and images are formed from the light reflected back from the retina. In this configuration, artifacts caused by retinal surface reflex are often encountered, which complicate quantitative interpretation of the reflection images. We present an alternative illumination method, which avoids these artifacts. The method uses deeply penetrating near-infrared (NIR) light delivered transcranially from the side of the head, and exploits multiple scattering to redirect a portion of the light towards the posterior eye...
August 1, 2018: Biomedical Optics Express
https://www.readbyqxmd.com/read/30308340/quantitative-endoscopic-comparison-of-contralateral-interhemispheric-transprecuneus-and-transtentorial-transcollateral-sulcus-approaches-to-the-atrium
#8
Xiaochun Zhao, Leandro Borba Moreira, Claudio Cavallo, Evgenii Belykh, Sirin Gandhi, Mohamed A Labib, Ali Tayebi Meybodi, Celene B Mulholland, Brandon D Liebelt, Michaela Lee, Peter Nakaji, Mark C Preul
OBJECTIVE: The contralateral interhemispheric transprecuneus approach (CITP) and the supracerebellar transtentorial transcollateral sulcus approach (STTC) are two novel approaches to access the atrium of the lateral ventricle. The authors quantitatively compared the two approaches. METHODS: Both approaches were performed in 6 sides of fixed and color-injected cadaver heads. We predefined 6 targets in the atrium for measurement and standardization of the approaches...
October 8, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/30300393/quantitative-optical-coherence-tomography-angiography-biomarkers-for-neovascular-age-related-macular-degeneration-in-remission
#9
Florence Coscas, Diogo Cabral, Telmo Pereira, Carlos Geraldes, Hemaxi Narotamo, Alexandra Miere, Marco Lupidi, Alexandre Sellam, Ana Papoila, Gabriel Coscas, Eric Souied
PURPOSE: To characterize quantitative optical coherence tomography angiography (OCT-A) parameters in active neovascular age-related macular degeneration (nAMD) patients under treatment and remission nAMD patients. DESIGN: Retrospective, cross-sectional study. PARTICIPANTS: One hundred and four patients of whom 72 were in Group 1 (active nAMD) and 32 in Group 2 (remission nAMD) based on SD-OCT (Spectral Domain OCT) qualitative morphology. METHODS: This study was conducted at the Centre Ophtalmologique de l'Odeon between June 2016 and December 2017...
2018: PloS One
https://www.readbyqxmd.com/read/30259090/morphologic-features-of-large-choroidal-vessel-layer-age-related-macular-degeneration-polypoidal-choroidal-vasculopathy-and-central-serous-chorioretinopathy
#10
REVIEW
Jiwon Baek, Jae Hyung Lee, Byung Joo Jung, Lee Kook, Won Ki Lee
PURPOSE: To compare choroidal vascular characteristics of age-related macular degeneration (AMD), polypoidal choroidal vasculopathy (PCV), and central serous chorioretinopathy (CSC) by qualitative and quantitative analyses using swept-source en face optical coherence tomographic (OCT) images. METHODS: Eyes with non-neovascular AMD (n = 32), neovascular AMD (n = 30), thick and thin choroid PCV (n = 33 and 27), and CSC (n = 34) were enrolled. Subfoveal choroidal thickness (SFCT) and the presence and patterns of pachyvessels were assessed...
December 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/30259004/changes-in-blood-flow-velocity-and-thickness-of-the-choroid-in-a-patient-with-leukemic-retinopathy
#11
Akari Takita, Yuki Hashimoto, Wataru Saito, Satoru Kase, Susumu Ishida
Purpose: Choroidal circulation hemodynamics in eyes with leukemia has not been quantitatively examined yet. We quantitatively examined changes in choroidal blood flow velocity and choroidal thickness at the macula by using laser speckle flowgraphy (LSFG) and enhanced depth imaging optical coherence tomography (EDI-OCT) in a patient with leukemic retinopathy. Observations: A 15-year-old boy presented with sudden central vision loss of his right eye. The patient's best-corrected visual acuity was 0...
December 2018: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/30252997/repeatability-of-arterial-spin-labeling-mri-in-measuring-blood-perfusion-in-the-human-eye
#12
Safal Khanal, Philip R K Turnbull, Ehsan Vaghefi, John R Phillips
BACKGROUND: Quantifying blood perfusion in ocular tissues is challenging, partly because the majority of the blood is carried by the choroid, which is difficult to visualize because it is located between the retina and sclera. PURPOSE/HYPOTHESIS: To evaluate the intra- and interday repeatability of MRI measures of chorio-retinal blood perfusion. STUDY TYPE: Prospective, cross-sectional, observational study. POPULATION: Twenty young healthy adults (six male, age: 25 ± 5 years) scanned twice within a single session repeated at the same time of day on 2 days...
September 25, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/30238069/quantitative-evaluation-of-choroidal-neovascularization-under-pro-re-nata-anti-vascular-endothelial-growth-factor-therapy-with-oct-angiography
#13
Scott M McClintic, Simon Gao, Jie Wang, Ahmed Hagag, Andreas K Lauer, Christina J Flaxel, Kavita Bhavsar, Thomas S Hwang, David Huang, Yali Jia, Steven T Bailey
Purpose: To use optical coherence tomography angiography (OCTA) derived quantitative metrics to assess the response of choroidal neovascularization to pro-re-nata (PRN) anti-endothelial growth factor (anti-VEGF) treatment in neovascular age-related macular degeneration (AMD). Design: Prospective longitudinal cohort study. Participants: Fourteen eyes from 14 study participants with treatment-naïve neovascular AMD were enrolled. Methods: Subjects were evaluated monthly and treated with intravitreal anti-VEGF agents under a PRN protocol for one year...
September 2018: Ophthalmology Retina
https://www.readbyqxmd.com/read/30230411/volumetric-voxelwise-apparent-diffusion-coefficient-histogram-analysis-for-differentiation-of-the-fourth-ventricular-tumors
#14
Seyedmehdi Payabvash, Tarik Tihan, Soonmee Cha
PURPOSE: We applied voxelwise apparent diffusion coefficient (ADC) histogram analysis in addition to structural magnetic resonance imaging (MRI) findings and patients' age for differentiation of intraaxial posterior fossa tumors involving the fourth ventricle. PARTICIPANTS AND METHODS: Pretreatment MRIs of 74 patients with intraaxial brain neoplasm involving the fourth ventricle, from January 1, 2004 to December 31, 2015, were reviewed. The tumor solid components were segmented and voxelwise ADC histogram variables were determined...
December 2018: Neuroradiology Journal
https://www.readbyqxmd.com/read/30221697/streptozotocin%C3%A2-induced-diabetic-mice-exhibit-reduced-experimental-choroidal-neovascularization-but-not-corneal-neovascularization
#15
Gaoqin Liu, Lei Chen, Qinhua Cai, Hongya Wu, Zhigang Chen, Xueguang Zhang, Peirong Lu
The present study aimed to investigate the effects of diabetes mellitus (DM) on the generation of experimental corneal neovascularization (CrNV) and choroidal neovascularization (ChNV). Diabetes was induced in mice by intraperitoneal injection of streptozotocin (STZ). Experimental CrNV and ChNV were induced by alkali injury and laser photocoagulation, respectively. CrNV and ChNV were compared between the STZ‑induced diabetic mice and control mice two weeks after injury. Relative expression of angiogenic factors was quantified by reverse transcription‑quantitative polymerase chain reaction, and progenitor cell or macrophage accumulation in the early phase following injury was examined by flow cytometric analysis...
September 3, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/30177829/quantitative-progression-of-retinitis-pigmentosa-by-optical-coherence-tomography-angiography
#16
Ruben Jauregui, Karen Sophia Park, Jimmy K Duong, Vinit B Mahajan, Stephen H Tsang
Optical coherence tomography angiography (OCT-A) is a non-invasive alternative to fluorescein angiography that allows for the study of the retinal and choroidal vasculatures. In this retrospective cohort study of 28 patients with retinitis pigmentosa (RP), we used OCT-A to quantify changes in perfusion density, foveal avascular zone (FAZ) area, and choriocapillaris blood flow over time and correlated these variables with ellipsoid zone (EZ) line width and best-corrected visual acuity (BCVA). Perfusion density decreased by 2...
September 3, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30148243/swept-source-oct-angiography-of-serpiginous-choroiditis
#17
Kaivon Pakzad-Vaezi, Kosar Khaksari, Zhongdi Chu, Russell N Van Gelder, Ruikang K Wang, Kathryn L Pepple
Purpose: To examine and quantify choriocapillaris lesions in active and quiescent serpiginous choroiditis (SC) using swept-source optical coherence tomography angiography (SS-OCTA) and en-face image analysis. Design: Prospective observational case series. Participants: Patients with a clinical diagnosis of SC. Methods: A SS-OCTA prototype was used to image active and quiescent serpiginous lesions longitudinally before and after anti-inflammatory treatment...
July 2018: Ophthalmology Retina
https://www.readbyqxmd.com/read/30140905/choroidal-flow-signal-in-late-onset-stargardt-disease-and-age-related-macular-degeneration-an-oct-angiography-study
#18
COMPARATIVE STUDY
Philipp L Müller, Maximilian Pfau, Philipp T Möller, Jennifer Nadal, Matthias Schmid, Moritz Lindner, Luis de Sisternes, Heidi Stöhr, Bernhard H F Weber, Christine Neuhaus, Philipp Herrmann, Steffen Schmitz-Valckenberg, Frank G Holz, Monika Fleckenstein
Purpose: To investigate the choroidal blood flow in areas within and adjacent to retinal pigment epithelium (RPE) atrophy secondary to late-onset Stargardt disease (STGD1) and age-related macular degeneration (AMD). Methods: A total of 43 eyes (23 STGD1 and 20 AMD) of patients with RPE atrophy and 25 eyes of healthy controls without ocular pathology underwent multimodal imaging including optical coherence tomography angiography (OCT-A; PLEX Elite 9000 Swept-Source OCT)...
March 20, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/30114413/lipid-derived-and-other-oxidative-modifications-of-retinal-proteins-in-a-rat-model-of-smith-lemli-opitz-syndrome
#19
Rebecca J Kapphahn, Michael J Richards, Deborah A Ferrington, Steven J Fliesler
Oxidative modification of proteins can perturb their structure and function, often compromising cellular viability. Such modifications include lipid-derived adducts (e.g., 4-hydroxynonenal (HNE) and carboxyethylpyrrole (CEP)) as well as nitrotyrosine (NTyr). We compared the retinal proteome and levels of such modifications in the AY9944-treated rat model of Smith-Lemli-Opitz syndrome (SLOS), in comparison to age-matched controls. Retinas harvested at 3 months of age were either subjected to proteomic analysis or to immuno-slot blot analysis, the latter probing blots with antibodies raised against HNE, CEP, and NTyr, followed by quantitative densitometry...
August 14, 2018: Experimental Eye Research
https://www.readbyqxmd.com/read/30108264/quantitative-analysis-of-retinal-and-choroidal-microvascular-changes-in-patients-with-diabetes
#20
Mirinae Kim, Seung Yong Choi, Young-Hoon Park
The relationship between choroidal and retinal microvascular changes has not yet been well described, and there were limited data on diagnostic ability of optical coherence tomography (OCT)-derived vascular parameters for determining diabetic retinopathy (DR) progression. We quantitatively analyzed OCT-derived vascular parameters at superficial (SCP) and deep retinal capillary plexus (DCP), and choroid. We assessed foveal avascular zone (FAZ), vessel density, vessel length density, and choroidal vascularity index in conjunction with DR stage...
August 14, 2018: Scientific Reports
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