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Choroid And Quantitative

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https://www.readbyqxmd.com/read/30098346/advanced-optical-coherence-tomography-angiography-analysis-of-age-related-macular-degeneration-complicated-by-onset-of-unilateral-choroidal-neovascularization
#1
Alessandro Arrigo, Emanuela Aragona, Luigi Capone, Luisa Pierro, Francesco Romano, Francesco Bandello, Maurizio Battaglia Parodi
PURPOSE: To analyze optical coherence tomography angiography (OCTA) quantitative features in patients affected by new-onset choroidal neovascularization (CNV) in one eye and early/intermediate age-related macular degeneration (AMD) in the fellow eye. DESIGN: Case-control study. SETTINGS: Clinical Practice. STUDY POPULATION: Thirty patients and thirty age-matched controls. OBSERVATION PROCEDURES: Both cohorts underwent complete ophthalmologic examination, including best corrected visual acuity (BCVA) measurement, biomicroscopy, fluorescein angiography (FA) and indocyanine green angiography (ICGA) examination (Spectralis HRA; Heidelberg Engineering, Germany), OCT and OCTA scans (DRI OCT Triton; Topcon Corporation, Japan)...
August 8, 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/30073364/oxygen-induced-retinopathy-and-choroidopathy-in-vivo-longitudinal-observation-of-vascular-changes-using-octa
#2
Yongjoo Kim, Hye Kyoung Hong, Jang Ryul Park, WooJhon Choi, Se Joon Woo, Kyu Hyung Park, Wang-Yuhl Oh
Purpose: The purpose of this study was to assess the retinal and choroidal vasculatures of an oxygen-induced retinopathy (OIR) rat model using optical coherence tomography angiography (OCTA) as well as to verify the performance of OCTA for visualizing in vivo vascular alterations, longitudinally and quantitatively. Methods: To induce OIR, Sprague Dawley rat pups were incubated in an 80% oxygen chamber from postnatal day 1 (P1) to P11 and returned to room air. OCTA imaging was performed in six eyes at P15, P18, P21, and P24...
August 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/30073352/rhythmic-regulation-of-photoreceptor-and-rpe-genes-important-for-vision-and-genetically-associated-with-severe-retinal-diseases
#3
Patrick Vancura, Erika Csicsely, Annalisa Leiser, P Michael Iuvone, Rainer Spessert
Purpose: The aim of the present study was to identify candidate genes for mediating daily adjustment of vision. Methods: Genes important for vision and genetically associated with severe retinal diseases were tested for 24-hour rhythms in transcript levels in neuronal retina, microdissected photoreceptors, photoreceptor-related pinealocytes, and retinal pigment epithelium-choroid (RPE-choroid) complex by using quantitative PCR. Results: Photoreceptors of wildtype mice display circadian clock-dependent regulation of visual arrestins (Arr1, Arr4) and the visual cycle gene Rdh12, whereas cells of the RPE-choroid exhibit light-dependent regulation of the visual cycle key genes Lrat, Rpe65, and Rdh5...
August 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/30046816/lactic-acid-upregulates-vegf-expression-in-macrophages-and-facilitates-choroidal-neovascularization
#4
Juha Song, Kihwang Lee, Sung Wook Park, Hyewon Chung, Daun Jung, Yi Rang Na, Hailian Quan, Chang Sik Cho, Jeong-Hwan Che, Jeong Hun Kim, Jae-Hak Park, Seung Hyeok Seok
Purpose: Lactic acid, the end product of glycolysis, has emerged as an immune-modulating metabolite in various diseases. In this study, we aimed to examine whether lactic acid contributes to the disease pathogenesis of choroidal neovascularization (CNV) and to investigate the role of macrophages in CNV pathogenesis. Methods: CNV was induced by laser photocoagulation in C57BL/6J mice. Lactic acid concentration was measured in the RPE-choroid region. Macrophage infiltration and VEGF were quantified by flow cytometry...
July 2, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/30038154/observer-variation-in-quantitative-assessment-of-retinal-shortening-with-ultrasound-in-patients-of-total-rhegmatogenous-retinal-detachment
#5
Brijesh Takkar, Nripen Gaur, Hameed Obedulla, Ramesh Chand Chauhan, Shreyas Temkar, Pradeep Venkatesh, Rohan Chawla, Atul Kumar
Purpose: To evaluate the interobserver variation in the assessment of retinal length to choroidal length ratio (RCR) as a marker for proliferative vitreoretinopathy (PVR) in cases of rhegmatogenous retinal detachment (RRD). Methods: This was a double-masked, prospective study at a tertiary center. Ultrasound was used to calculate RCR in 50 eyes with total RRD by two observers. Both observers were trained after the first round of calculations, and all the calculations were repeated as before...
August 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/30025092/quantity-of-intraretinal-hyperreflective-foci-in-patients-with-intermediate-age-related-macular-degeneration-correlates-with-1-year-progression
#6
Marco Nassisi, Wenying Fan, Yue Shi, Jianqin Lei, Enrico Borrelli, Michael Ip, Srinivas R Sadda
Purpose: The purpose of this study was to evaluate the correlation between quantity of intraretinal hyperreflective foci (HRF) in the eye with intermediate AMD and progression to late AMD. Methods: Volume optical coherence tomography (OCT) scans from 114 eyes of 114 patients were retrospectively reviewed. HRF were assessed both qualitatively and quantitatively. Five sequential en face slabs from midretina were thresholded to isolate the HRF. These five slabs were recombined, and HRF area was measured in the whole 6 × 6-mm image (HRFTOT) and within the central 3-mm (HRF3mm) and 5-mm (HRF5mm) regions...
July 2, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/30025088/ascorbate-suppresses-vegf-expression-in-retinal-pigment-epithelial-cells
#7
David W Sant, Vladimir Camarena, Sushmita Mustafi, Yiwen Li, Zachary Wilkes, Derek Van Booven, Rong Wen, Gaofeng Wang
Purpose: To investigate the impact of ascorbate, via DNA hydroxymethylation, on VEGF expression in retinal pigment epithelial (RPE) cells. Methods: Dot-blot and hydroxymethylated DNA immunoprecipitation sequencing were applied to evaluate the impact of ascorbate on DNA hydroxymethylation in ARPE-19 cells. RNA sequencing (RNA-seq) was carried out to analyze the transcriptome. Quantitative RT-PCR and ELISA were conducted to examine the transcription and secretion of VEGF from cultured cells...
July 2, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29977804/protective-effects-of-a-novel-drug-rc28-e-blocking-both-vegf-and-fgf2-on-early-diabetic-rat-retina
#8
Qian-Hui Yang, Yan Zhang, Jing Jiang, Mian-Mian Wu, Qian Han, Qi-Yu Bo, Guang-Wei Yu, Yu-Sha Ru, Xun Liu, Min Huang, Ling Wang, Xiao-Min Zhang, Jian-Min Fang, Xiao-Rong Li
AIM: To investigate protective effects of a novel recombinant decoy receptor drug RC28-E on retinal damage in early diabetic rats. METHODS: The streptozotocin (STZ)-induced diabetic rats were randomly divided into 6 groups: diabetes mellitus (DM) group (saline, 3 µL/eye); RC28-E at low (0.33 µg/µL, 3 µL), medium (1 µg/µL, 3 µL), and high (3 µg/µL, 3 µL) dose groups; vascular endothelial growth factor (VEGF) Trap group (1 µg/µL, 3 µL); fibroblast growth factor (FGF) Trap group (1 µg/µL, 3 µL)...
2018: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/29971444/prediction-of-individual-disease-conversion-in-early-amd-using-artificial-intelligence
#9
Ursula Schmidt-Erfurth, Sebastian M Waldstein, Sophie Klimscha, Amir Sadeghipour, Xiaofeng Hu, Bianca S Gerendas, Aaron Osborne, Hrvoje Bogunovic
Purpose: While millions of individuals show early age-related macular degeneration (AMD) signs, yet have excellent vision, the risk of progression to advanced AMD with legal blindness is highly variable. We suggest means of artificial intelligence to individually predict AMD progression. Methods: In eyes with intermediate AMD, progression to the neovascular type with choroidal neovascularization (CNV) or the dry type with geographic atrophy (GA) was diagnosed based on standardized monthly optical coherence tomography (OCT) images by independent graders...
July 2, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29946830/assessment-of-measurement-methods-of-posterior-inflammation-in-stromal-choroiditis-the-value-of-quantitative-outcome-measures-versus-the-presently-qualitatively-based-paradigm
#10
K Gillmann, A El Ameen, R Massy, F Fabro, A Gasc, C P Herbort
PURPOSE: To assess posterior inflammation using a fluorescein (FA)/indocyanine-green angiography (ICGA) scoring system, and compare them to the presently recommended outcome measure, the standardization of uveitis nomenclature vitreous haze score (SUN-VH) in stromal choroiditis. METHODS: This was a retrospective study on patients with a diagnosis of ocular sarcoidosis(OS), ocular tuberculosis(OT), Birdshot retinochoroiditis(BRC) and Vogt-Koyanagi-Harada disease(VKH) seen in the Centre for Ophthalmic Specialized Care, Lausanne, Switzerland...
June 26, 2018: International Ophthalmology
https://www.readbyqxmd.com/read/29880905/author-correction-quantitative-shadow-compensated-optical-coherence-tomography-of-choroidal-vasculature
#11
Kiran Kumar Vupparaboina, Kunal K Dansingani, Abhilash Goud, Mohammed Abdul Rasheed, Fayez Jawed, Soumya Jana, Ashutosh Richhariya, K Bailey Freund, Jay Chhablani
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
June 7, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29847659/neurofibromin-deficiency-induces-endothelial-cell-proliferation-and-retinal-neovascularization
#12
Hanfang Zhang, Farlyn Z Hudson, Zhimin Xu, Rebekah Tritz, Modesto Rojas, Chintan Patel, Stephen B Haigh, Zsuzsanna Bordán, David A Ingram, David J Fulton, Neal L Weintraub, Ruth B Caldwell, Brian K Stansfield
Purpose: Neurofibromatosis type 1 (NF1) is the result of inherited mutations in the NF1 tumor suppressor gene, which encodes the protein neurofibromin. Eye manifestations are common in NF1 with recent reports describing a vascular dysplasia in the retina and choroid. Common features of NF1 retinopathy include tortuous and dilated feeder vessels that terminate in capillary tufts, increased endothelial permeability, and neovascularization. Given the retinal vascular phenotype observed in persons with NF1, we hypothesize that preserving neurofibromin may be a novel strategy to control pathologic retinal neovascularization...
May 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29847645/comparison-of-sd-optical-coherence-tomography-angiography-and-indocyanine-green-angiography-in-type-1-and-2-neovascular-age-related-macular-degeneration
#13
Reinhard Told, Stefan Sacu, Alexander Hecht, Magdalena Baratsits, Katharina Eibenberger, Maria E Kroh, Sandra Rezar-Dreindl, Ferdinand G Schlanitz, Guenther Weigert, Andreas Pollreisz, Ursula Schmidt-Erfurth
Purpose: The purpose of this study is to compare the ability of spectral domain optical coherence tomography angiography (SD-OCTA) and indocyanine green angiography (ICGA) to detect and measure lesion area in patients with type 1 and 2 choroidal neovascularization (CNV). Methods: Types 1 and 2 neovascular AMD (nAMD) were included in this prospective and observational case series. ETDRS best-corrected visual acuity (BCVA), ophthalmic examination with funduscopy, OCTA (AngioVue), fluorescein angiography (FA), ICGA, and OCT (Spectralis) were performed...
May 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29844084/acute-macular-neuroretinopathy-pathogenetic-insights-from-optical-coherence-tomography-angiography
#14
Giuseppe Casalino, Alessandro Arrigo, Francesco Romano, Marion R Munk, Francesco Bandello, Maurizio Battaglia Parodi
AIM: To describe the optical coherence tomography angiography (OCT-A) features of patients affected by acute macular neuroretinopathy (AMN). METHODS: This is a prospective, observational, cross-sectional study. Multimodal imaging, including spectral domain OCT (Spectralis HRA+OCT; Heidelberg Engineering, Heidelberg, Germany) and 6×6 mm swept source OCT-A (ZEISS PLEX Elite 9000; ZEISS, Dublin, California), was performed on all patients. The primary outcome measure was assessment of the vascular alterations of the superficial (SCP) and deep (DCP) capillary plexuses and choriocapillaris (CC)...
May 29, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29794471/optical-coherence-tomography-angiography-in-glaucoma-a-review
#15
Lukas Van Melkebeke, João Barbosa-Breda, Marc Huygens, Ingeborg Stalmans
BACKGROUND: Glaucoma is the leading cause of irreversible blindness worldwide. Several techniques exist for the diagnosis and follow-up of patients. Optical coherence tomography (OCT) angiography (OCTA) is a recently developed technique that provides a quantitative assessment of the microcirculation of the retina and choroid in a fast, noninvasive way. Despite it being a novel technique, several publications have already been done in the glaucoma field. However, a summary of findings is currently lacking...
May 24, 2018: Ophthalmic Research
https://www.readbyqxmd.com/read/29792846/adenosine-receptor-distribution-in-rhesus-monkey-ocular-tissue
#16
Krista M Beach, Li-Fang Hung, Baskar Arumugam, Earl L Smith, Lisa A Ostrin
Adenosine receptor (ADOR) antagonists, such as 7-methylxanthine (7-MX), have been shown to slow myopia progression in humans and animal models. Adenosine receptors are found throughout the body, and regulate the release of neurotransmitters such as dopamine and glutamate. However, the role of adenosine in eye growth is unclear. Evidence suggests that 7-MX increases scleral collagen fibril diameter, hence preventing axial elongation. This study used immunohistochemistry (IHC) and reverse-transcription quantitative polymerase chain reaction (RT-qPCR) to examine the distribution of the four ADORs in the normal monkey eye to help elucidate potential mechanisms of action...
May 21, 2018: Experimental Eye Research
https://www.readbyqxmd.com/read/29763612/topographic-correspondence-of-macular-atrophy-with-choroidal-neovascularization-in-ranibizumab-treated-eyes-of-the-trex-amd-trial
#17
Nizar Saleh Abdelfattah, Amirhossein Hariri, Mayss Al-Sheikh, Sean Pitetta, Adel Ebraheem, Charles C Wykoff, SriniVas R Sadda
PURPOSE: To quantify the extent of topographic correspondence between baseline (BSL) CNV and macular atrophy (MA) at follow-up in eyes with NVAMD. DESIGN: Post hoc analysis of randomized, controlled clinical trial data. METHODS: Sixty treatment-naïve neovascular age-related macular degeneration (NVAMD) patients from TREX-AMD trial were followed for 18-months. Regions of month-18 macular atrophy (MA) were graded on fundus autofluorescence (FAF) with guidance of spectral domain optical coherence tomography (SD-OCT)...
May 12, 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29746411/reduced-choriocapillaris-flow-in-eyes-with-type-3-neovascularization-and-age-related-macular-degeneration
#18
Enrico Borrelli, Eric H Souied, K Bailey Freund, Giuseppe Querques, Alexandra Miere, Orly Gal-Or, Riccardo Sacconi, SriniVas R Sadda, David Sarraf
PURPOSE: To study choriocapillaris (CC) flow in eyes with Type 3 neovascularization (NV) and age-related macular degeneration, using optical coherence tomography angiography analysis. METHODS: In this multicenter, retrospective, observational study, we collected data from 21 patients with unilateral Type 3 NV and age-related macular degeneration, based on clinical examination, structural optical coherence tomography, and fluorescein angiography when available. An additional group of 20 nonneovascular age-related macular degeneration eyes with unilateral Type 1 or Type 2 NV due to age-related macular degeneration was included for comparison...
April 30, 2018: Retina
https://www.readbyqxmd.com/read/29698675/human-choroidal-melanocytes-express-functional-toll-like-receptors-tlrs
#19
Adrian V Cioanca, Peter J McCluskey, Steven S Eamegdool, Michele C Madigan
Toll-like receptors (TLRs) are a class of pattern recognition receptors that sense highly conserved pathogen associated antigenic determinants, triggering an innate immune response and subsequently instructing the adaptive immune system so that together, the pathogen can be eliminated. TLRs are widely distributed in human ocular tissues and cell types, and are active players in ocular inflammation. To date, the presence and function of TLRs on human choroidal melanocytes (HCMs), the most abundant choroidal cell type, have not been characterized...
August 2018: Experimental Eye Research
https://www.readbyqxmd.com/read/29691426/quantitative-shadow-compensated-optical-coherence-tomography-of-choroidal-vasculature
#20
Kiran Kumar Vupparaboina, Kunal K Dansingani, Abhilash Goud, Mohammed Abdul Rasheed, Fayez Jawed, Soumya Jana, Ashutosh Richhariya, K Bailey Freund, Jay Chhablani
Conventionally rendered optical coherence tomography (OCT) images of the posterior segment contain shadows which influence the visualization of deep structures such as the choroid. The purpose of this study was to determine whether OCT shadow compensation (SC) alters the appearance of the choroid and the apparent choroidal vascularity index (CVI), an OCT-derived estimated ratio of luminal to total choroidal volume. All scans were shadow compensated using a previously published algorithm, binarized using a novel validated algorithm and extracted binarized choroid to estimate CVI...
April 24, 2018: Scientific Reports
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