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Andre Olivier

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https://www.readbyqxmd.com/read/30078706/dual-roles-of-poly-da-dt-tracts-in-replication-initiation-and-fork-collapse
#1
Anthony Tubbs, Sriram Sridharan, Niek van Wietmarschen, Yaakov Maman, Elsa Callen, Andre Stanlie, Wei Wu, Xia Wu, Amanda Day, Nancy Wong, Mianmian Yin, Andres Canela, Haiqing Fu, Christophe Redon, Steven C Pruitt, Yan Jaszczyszyn, Mirit I Aladjem, Peter D Aplan, Olivier Hyrien, André Nussenzweig
Replication origins, fragile sites, and rDNA have been implicated as sources of chromosomal instability. However, the defining genomic features of replication origins and fragile sites are among the least understood elements of eukaryote genomes. Here, we map sites of replication initiation and breakage in primary cells at high resolution. We find that replication initiates between transcribed genes within nucleosome-depleted structures established by long asymmetrical poly(dA:dT) tracts flanking the initiation site...
July 24, 2018: Cell
https://www.readbyqxmd.com/read/30064988/treatment-with-camu-camu-myrciaria-dubia-prevents-obesity-by-altering-the-gut-microbiota-and-increasing-energy-expenditure-in-diet-induced-obese-mice
#2
Fernando F Anhê, Renato T Nachbar, Thibault V Varin, Jocelyn Trottier, Stéphanie Dudonné, Mélanie Le Barz, Perrine Feutry, Geneviève Pilon, Olivier Barbier, Yves Desjardins, Denis Roy, André Marette
OBJECTIVE: The consumption of fruits is strongly associated with better health and higher bacterial diversity in the gut microbiota (GM). Camu camu ( Myrciaria dubia ) is an Amazonian fruit with a unique phytochemical profile, strong antioxidant potential and purported anti-inflammatory potential. DESIGN: By using metabolic tests coupled with 16S rRNA gene-based taxonomic profiling and faecal microbial transplantation (FMT), we have assessed the effect of a crude extract of camu camu (CC) on obesity and associated immunometabolic disorders in high fat/high sucrose (HFHS)-fed mice...
July 31, 2018: Gut
https://www.readbyqxmd.com/read/30046129/gut-bacterial-microbiota-and-its-resistome-rapidly-recover-to-basal-state-levels-after-short-term-amoxicillin-clavulanic-acid-treatment-in-healthy-adults
#3
Chad W MacPherson, Olivier Mathieu, Julien Tremblay, Julie Champagne, André Nantel, Stéphanie-Anne Girard, Thomas A Tompkins
Clinical effects of antimicrobials and probiotics in combination have been reported, however, little is known about their impact on gut microbiota and its resistome. In this study 16S rRNA gene amplicon, shotgun metagenomics sequencing and antibiotic resistance (ABR) microarray were used on fecal samples of 70 healthy participants, taken at four time points in probiotic (Lactobacillus rhamnosus R0011 and Lactobacillus helveticus R0052) and placebo groups to profile the gut bacterial microbiota and its resistome following administration of amoxicillin-clavulanic acid for one week...
July 25, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30042063/docetaxel-cisplatin-and-fluorouracil-chemotherapy-for-metastatic-or-unresectable-locally-recurrent-anal-squamous-cell-carcinoma-epitopes-hpv02-a-multicentre-single-arm-phase-2-study
#4
Stefano Kim, Eric François, Thierry André, Emmanuelle Samalin, Marine Jary, Farid El Hajbi, Nabil Baba-Hamed, Simon Pernot, Marie-Christine Kaminsky, Olivier Bouché, Jérôme Desrame, Mustapha Zoubir, François Ghiringhelli, Aurélie Parzy, Christelle De La Fouchardiere, Denis Smith, Mélanie Deberne, Laurie Spehner, Nicolas Badet, Olivier Adotevi, Amélie Anota, Aurélia Meurisse, Dewi Vernerey, Julien Taieb, Véronique Vendrely, Bruno Buecher, Christophe Borg
BACKGROUND: The incidence of anal squamous cell carcinoma has been increasing markedly in the past few decades. Currently, there is no validated treatment for advanced-stage anal squamous cell carcinoma. Therefore, we aimed to validate the clinical activity and safety of docetaxel, cisplatin, and fluorouracil (DCF) chemotherapy in patients with metastatic or unresectable locally recurrent anal squamous cell carcinoma. METHODS: We did a multicentre, single-arm, phase 2 study...
July 2, 2018: Lancet Oncology
https://www.readbyqxmd.com/read/30037846/toll-like-receptor-4-induced-glycolytic-burst-in-human-monocyte-derived-dendritic-cells-results-from-p38-dependent-stabilization-of-hif-1%C3%AE-and-increased-hexokinase-ii-expression
#5
Laure Perrin-Cocon, Anne Aublin-Gex, Olivier Diaz, Christophe Ramière, Francesco Peri, Patrice André, Vincent Lotteau
Cell metabolism now appears as an essential regulator of immune cells activation. In particular, TLR stimulation triggers metabolic reprogramming of dendritic cells (DCs) with an increased glycolytic flux, whereas inhibition of glycolysis alters their functional activation. The molecular mechanisms involved in the control of glycolysis upon TLR stimulation are poorly understood for human DCs. TLR4 activation of human monocyte-derived DCs (MoDCs) stimulated glycolysis with an increased glucose consumption and lactate production...
July 23, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/30026036/deep-brain-stimulation-does-not-enhance-neuroinflammation-in-multiple-system-atrophy
#6
Miguel Lopez-Cuina, Pierre-Olivier Fernagut, Marie-Hélène Canron, Anne Vital, Béatrice Lannes, André Maues De Paula, Nathalie Streichenberger, Dominique Guehl, Philippe Damier, Alexandre Eusebio, Jean-Luc Houeto, François Tison, Christine Tranchant, François Viallet, Tatiana Witjas, Stéphane Thobois, Wassilios G Meissner
Slowly progressive, levodopa-responsive multiple system atrophy (MSA) may be misdiagnosed as Parkinson's disease (PD). Deep brain stimulation (DBS) is mostly ineffective in these patients and may even worsen the clinical course. Here we assessed whether neuropathological differences between patients with MSA who were treated with DBS of the subthalamic nucleus because of a misleading clinical presentation and typical disease cases may explain the more benign disease course of the former, and also the rapid clinical decline after surgery...
July 17, 2018: Neurobiology of Disease
https://www.readbyqxmd.com/read/30018877/considerations-and-consequences-of-allowing-dna-sequence-data-as-types-of-fungal-taxa
#7
Juan Carlos Zamora, Måns Svensson, Roland Kirschner, Ibai Olariaga, Svengunnar Ryman, Luis Alberto Parra, József Geml, Anna Rosling, Slavomír Adamčík, Teuvo Ahti, M Catherine Aime, A Martyn Ainsworth, László Albert, Edgardo Albertó, Alberto Altés García, Dmitry Ageev, Reinhard Agerer, Begoña Aguirre-Hudson, Joe Ammirati, Harry Andersson, Claudio Angelini, Vladimír Antonín, Takayuki Aoki, André Aptroot, Didier Argaud, Blanca Imelda Arguello Sosa, Arne Aronsen, Ulf Arup, Bita Asgari, Boris Assyov, Violeta Atienza, Ditte Bandini, João Luís Baptista-Ferreira, Hans-Otto Baral, Tim Baroni, Robert Weingart Barreto, Henry Beker, Ann Bell, Jean-Michel Bellanger, Francesco Bellù, Martin Bemmann, Mika Bendiksby, Egil Bendiksen, Katriina Bendiksen, Lajos Benedek, Anna Bérešová-Guttová, Franz Berger, Reinhard Berndt, Annarosa Bernicchia, Alona Yu Biketova, Enrico Bizio, Curtis Bjork, Teun Boekhout, David Boertmann, Tanja Böhning, Florent Boittin, Carlos G Boluda, Menno W Boomsluiter, Jan Borovička, Tor Erik Brandrud, Uwe Braun, Irwin Brodo, Tatiana Bulyonkova, Harold H Burdsall, Bart Buyck, Ana Rosa Burgaz, Vicent Calatayud, Philippe Callac, Emanuele Campo, Massimo Candusso, Brigitte Capoen, Joaquim Carbó, Matteo Carbone, Rafael F Castañeda-Ruiz, Michael A Castellano, Jie Chen, Philippe Clerc, Giovanni Consiglio, Gilles Corriol, Régis Courtecuisse, Ana Crespo, Cathy Cripps, Pedro W Crous, Gladstone Alves da Silva, Meiriele da Silva, Marjo Dam, Nico Dam, Frank Dämmrich, Kanad Das, Linda Davies, Eske De Crop, Andre De Kesel, Ruben De Lange, Bárbara De Madrignac Bonzi, Thomas Edison E Dela Cruz, Lynn Delgat, Vincent Demoulin, Dennis E Desjardin, Paul Diederich, Bálint Dima, Maria Martha Dios, Pradeep Kumar Divakar, Clovis Douanla-Meli, Brian Douglas, Elisandro Ricardo Drechsler-Santos, Paul S Dyer, Ursula Eberhardt, Damien Ertz, Fernando Esteve-Raventós, Javier Angel Etayo Salazar, Vera Evenson, Guillaume Eyssartier, Edit Farkas, Alain Favre, Anna G Fedosova, Mario Filippa, Péter Finy, Adam Flakus, Simón Fos, Jacques Fournier, André Fraiture, Paolo Franchi, Ana Esperanza Franco Molano, Gernot Friebes, Andreas Frisch, Alan Fryday, Giuliana Furci, Ricardo Galán Márquez, Matteo Garbelotto, Joaquina María García-Martín, Mónica A García Otálora, Dania García Sánchez, Alain Gardiennet, Sigisfredo Garnica, Isaac Garrido Benavent, Genevieve Gates, Alice da Cruz Lima Gerlach, Masoomeh Ghobad-Nejhad, Tatiana B Gibertoni, Tine Grebenc, Irmgard Greilhuber, Bella Grishkan, Johannes Z Groenewald, Martin Grube, Gérald Gruhn, Cécile Gueidan, Gro Gulden, Luis Fp Gusmão, Josef Hafellner, Michel Hairaud, Marek Halama, Nils Hallenberg, Roy E Halling, Karen Hansen, Christoffer Bugge Harder, Jacob Heilmann-Clausen, Stip Helleman, Alain Henriot, Margarita Hernandez-Restrepo, Raphaël Herve, Caroline Hobart, Mascha Hoffmeister, Klaus Høiland, Jan Holec, Håkon Holien, Karen Hughes, Vit Hubka, Seppo Huhtinen, Boris Ivančević, Marian Jagers, Walter Jaklitsch, AnnaElise Jansen, Ruvishika S Jayawardena, Thomas Stjernegaard Jeppesen, Mikael Jeppson, Peter Johnston, Per Magnus Jørgensen, Ingvar Kärnefelt, Liudmila B Kalinina, Gintaras Kantvilas, Mitko Karadelev, Taiga Kasuya, Ivona Kautmanová, Richard W Kerrigan, Martin Kirchmair, Anna Kiyashko, Dániel G Knapp, Henning Knudsen, Kerry Knudsen, Tommy Knutsson, Miroslav Kolařík, Urmas Kõljalg, Alica Košuthová, Attila Koszka, Heikki Kotiranta, Vera Kotkova, Ondřej Koukol, Jiří Kout, Gábor M Kovács, Martin Kříž, Åsa Kruys, Viktor Kučera, Linas Kudzma, Francisco Kuhar, Martin Kukwa, T K Arun Kumar, Vladimír Kunca, Ivana Kušan, Thomas W Kuyper, Carlos Lado, Thomas Læssøe, Patrice Lainé, Ewald Langer, Ellen Larsson, Karl-Henrik Larsson, Gary Laursen, Christian Lechat, Serena Lee, James C Lendemer, Laura Levin, Uwe Lindemann, Håkan Lindström, Xingzhong Liu, Regulo Carlos Llarena Hernandez, Esteve Llop, Csaba Locsmándi, Deborah Jean Lodge, Michael Loizides, László Lőkös, Jennifer Luangsa-Ard, Matthias Lüderitz, Thorsten Lumbsch, Matthias Lutz, Dan Mahoney, Ekaterina Malysheva, Vera Malysheva, Patinjareveettil Manimohan, Yasmina Marin-Felix, Guilhermina Marques, Rubén Martínez-Gil, Guy Marson, Gerardo Mata, P Brandon Matheny, Geir Harald Mathiassen, Neven Matočec, Helmut Mayrhofer, Mehdi Mehrabi, Ireneia Melo, Armin Mešić, Andrew S Methven, Otto Miettinen, Ana M Millanes Romero, Andrew N Miller, James K Mitchell, Roland Moberg, Pierre-Arthur Moreau, Gabriel Moreno, Olga Morozova, Asunción Morte, Lucia Muggia, Guillermo Muñoz González, Leena Myllys, István Nagy, László G Nagy, Maria Alice Neves, Tuomo Niemelä, Pier Luigi Nimis, Nicolas Niveiro, Machiel E Noordeloos, Anders Nordin, Sara Raouia Noumeur, Yuri Novozhilov, Jorinde Nuytinck, Esteri Ohenoja, Patricia Oliveira Fiuza, Alan Orange, Alexander Ordynets, Beatriz Ortiz-Santana, Leticia Pacheco, Ferenc Pál-Fám, Melissa Palacio, Zdeněk Palice, Viktor Papp, Kadri Pärtel, Julia Pawlowska, Aurelia Paz, Ursula Peintner, Shaun Pennycook, Olinto Liparini Pereira, Pablo Pérez Daniëls, Miquel À Pérez-De-Gregorio Capella, Carlos Manuel Pérez Del Amo, Sergio Pérez Gorjón, Sergio Pérez-Ortega, Israel Pérez-Vargas, Brian A Perry, Jens H Petersen, Ronald H Petersen, Donald H Pfister, Chayanard Phukhamsakda, Marcin Piątek, Meike Piepenbring, Raquel Pino-Bodas, Juan Pablo Pinzón Esquivel, Paul Pirot, Eugene S Popov, Orlando Popoff, María Prieto Álvaro, Christian Printzen, Nadezhda Psurtseva, Witoon Purahong, Luis Quijada, Gerhard Rambold, Natalia A Ramírez, Huzefa Raja, Olivier Raspé, Tania Raymundo, Martina Réblová, Yury A Rebriev, Juan de Dios Reyes García, Miguel Ángel Ribes Ripoll, Franck Richard, Mike J Richardson, Víctor J Rico, Gerardo Lucio Robledo, Flavia Rodrigues Barbosa, Cristina Rodriguez-Caycedo, Pamela Rodriguez-Flakus, Anna Ronikier, Luis Rubio Casas, Katerina Rusevska, Günter Saar, Irja Saar, Isabel Salcedo, Sergio M Salcedo Martínez, Carlos A Salvador Montoya, Santiago Sánchez-Ramírez, J Vladimir Sandoval-Sierra, Sergi Santamaria, Josiane Santana Monteiro, Hans Josef Schroers, Barbara Schulz, Geert Schmidt-Stohn, Trond Schumacher, Beatrice Senn-Irlet, Hana Ševčíková, Oleg Shchepin, Takashi Shirouzu, Anton Shiryaev, Klaus Siepe, Esteban B Sir, Mohammad Sohrabi, Karl Soop, Viacheslav Spirin, Toby Spribille, Marc Stadler, Joost Stalpers, Soili Stenroos, Ave Suija, Stellan Sunhede, Sten Svantesson, Sigvard Svensson, Tatyana Yu Svetasheva, Krzysztof Świerkosz, Heidi Tamm, Hatira Taskin, Adrien Taudière, Jan-Olof Tedebrand, Raúl Tena Lahoz, Marina Temina, Arne Thell, Marco Thines, Göran Thor, Holger Thüs, Leif Tibell, Sanja Tibell, Einar Timdal, Zdenko Tkalčec, Tor Tønsberg, Gérard Trichies, Dagmar Triebel, Andrei Tsurykau, Rodham E Tulloss, Veera Tuovinen, Miguel Ulloa Sosa, Carlos Urcelay, François Valade, Ricardo Valenzuela Garza, Pieter van den Boom, Nicolas Van Vooren, Aida M Vasco-Palacios, Jukka Vauras, Juan Manuel Velasco Santos, Else Vellinga, Annemieke Verbeken, Per Vetlesen, Alfredo Vizzini, Hermann Voglmayr, Sergey Volobuev, Wolfgang von Brackel, Elena Voronina, Grit Walther, Roy Watling, Evi Weber, Mats Wedin, Øyvind Weholt, Martin Westberg, Eugene Yurchenko, Petr Zehnálek, Huang Zhang, Mikhail P Zhurbenko, Stefan Ekman
Nomenclatural type definitions are one of the most important concepts in biological nomenclature. Being physical objects that can be re-studied by other researchers, types permanently link taxonomy (an artificial agreement to classify biological diversity) with nomenclature (an artificial agreement to name biological diversity). Two proposals to amend the International Code of Nomenclature for algae, fungi, and plants (ICN), allowing DNA sequences alone (of any region and extent) to serve as types of taxon names for voucherless fungi (mainly putative taxa from environmental DNA sequences), have been submitted to be voted on at the 11th International Mycological Congress (Puerto Rico, July 2018)...
June 2018: IMA Fungus
https://www.readbyqxmd.com/read/30004016/hydroxychloroquine-as-a-novel-therapeutic-approach-in-mast-cell-activation-diseases
#8
Eric Espinosa, Salvatore Valitutti, Michel Laroche, Camille Laurent, Pol André Apoil, Olivier Hermine, Michel Lavit, Carle Paul, Cristina Bulai Livideanu
There is no therapeutic agent approved in cutaneous mastocytosis and mast cell activation syndrome. We report the efficacy of hydroxychloroquine in four patients with cutaneous mastocytosis (n = 2) and mast cell activation syndrome (n = 2). We show that this molecule reduces the long-term survival of primary human mast cells, interferes with lysosome function and leads to the accumulation of non-functional tryptase in the mast cell granules. Furthermore, hydroxychloroquine decreases the production of pro-inflammatory mediators...
July 10, 2018: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/29978366/impact-of-combination-chemotherapy-in-peritoneal-mesothelioma-hyperthermic-intraperitoneal-chemotherapy-hipec-the-renape-study
#9
Brice Malgras, Etienne Gayat, Olivier Aoun, Réa Lo Dico, Clarisse Eveno, Karine Pautrat, Jean-Baptiste Delhorme, Guillaume Passot, Frédéric Marchal, Olivia Sgarbura, Gwenael Ferron, Diane Goéré, Thierry Andre, Marc Pocard
BACKGROUND: The introduction of cytoreductive surgery (CRS) in combination with hyperthermic intraperitoneal chemotherapy (HIPEC) improved the prognosis of selected patients with peritoneal mesothelioma (PM). OBJECTIVE: The objective of our study was to evaluate whether different HIPEC agents were associated with different outcomes in patients with PM. METHODS: From the RENAPE database, we selected all patients with histology-proven PM who underwent CRS + HIPEC from 1989 to 2014...
July 5, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29970296/drug-administration-to-the-wrong-nursing-home-residents-reported-to-the-qu%C3%A3-bec-poison-center-a-retrospective-study
#10
Pierre-André Dubé, Jessie Portelance, Olivier Corbeil, Mélanie Tessier, Maude St-Onge
OBJECTIVE: This study examined the association between the administration of drugs to the wrong nursing home residents with a need for hospital treatment or as an indicator of mortality. DESIGN: A retrospective observational study of medical records from February 1, 2016, to January 31, 2017. SETTING: Calls made to the Quebec Poison Center. PARTICIPANTS: Nursing home residents aged ≥65 years. INTERVENTION(S): Medication administered to the wrong resident...
June 30, 2018: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/29953458/feasibility-benefit-and-risk-of-systematic-intraoperative-cholangiogram-in-patients-undergoing-emergency-cholecystectomy
#11
Pouya Iranmanesh, Olivier Tobler, Sandra De Sousa, Axel Andres, Jean-Louis Frossard, Philippe Morel, Christian Toso
BACKGROUND: The role of intraoperative cholangiogram (IOC) during cholecystectomy is debated. The aim of the present study was to evaluate the feasibility, benefit and risk of performing systematic IOC in patients undergoing cholecystectomy for acute gallstone-related disease. METHODS: Between July 2013 and January 2015, all patients admitted for an acute gallstone-related condition and undergoing same-hospital-stay cholecystectomy were prospectively followed. IOC was systematically attempted and predictors of IOC failure were analyzed...
2018: PloS One
https://www.readbyqxmd.com/read/29846707/deep-brain-stimulation-of-the-pedunculopontine-nucleus-area-in-parkinson-disease-mri-based-anatomoclinical-correlations-and-optimal-target
#12
Laurent Goetz, Manik Bhattacharjee, Murielle U Ferraye, Valérie Fraix, Carina Maineri, Daniela Nosko, Albert J Fenoy, Brigitte Piallat, Napoléon Torres, Alexandre Krainik, Eric Seigneuret, Olivier David, Martin Parent, André Parent, Pierre Pollak, Alim-Louis Benabid, Bettina Debu, Stéphan Chabardès
BACKGROUND: Experimental studies led to testing of deep brain stimulation (DBS) of the pedunculopontine nucleus (PPN) as a new therapy to treat freezing of gait (FOG) in Parkinson disease (PD). Despite promising initial results fueling a growing interest toward that approach, several clinical studies reported heterogeneity in patient responses. Variation in the position of electrode contacts within the rostral brainstem likely contributes to such heterogeneity. OBJECTIVE: To provide anatomoclinical correlations of the effect of DBS of the caudal mesencephalic reticular formation (cMRF) including the PPN to treat FOG by comparing the normalized positions of the active contacts among a series of 11 patients at 1- and 2-yr follow-up and to provide an optimal target through an open-label study...
May 25, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29846285/pericarditis-in-a-department-of-internal-medicine-causes-and-diagnostic-work-up
#13
Louis Olagne, Perrine Smets, Romain Eschalier, Lucie Cassagnes, Olivier Aumaître, Marc André
No abstract text is available yet for this article.
July 2018: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/29844208/mechanisms-of-crystalloid-versus-colloid-osmosis-across-the-peritoneal-membrane
#14
Johann Morelle, Amadou Sow, Charles-André Fustin, Catherine Fillée, Elvia Garcia-Lopez, Bengt Lindholm, Eric Goffin, Fréderic Vandemaele, Bengt Rippe, Carl M Öberg, Olivier Devuyst
Background Osmosis drives transcapillary ultrafiltration and water removal in patients treated with peritoneal dialysis. Crystalloid osmosis, typically induced by glucose, relies on dialysate tonicity and occurs through endothelial aquaporin-1 water channels and interendothelial clefts. In contrast, the mechanisms mediating water flow driven by colloidal agents, such as icodextrin, and combinations of osmotic agents have not been evaluated. Methods We used experimental models of peritoneal dialysis in mouse and biophysical studies combined with mathematical modeling to evaluate the mechanisms of colloid versus crystalloid osmosis across the peritoneal membrane and to investigate the pathways mediating water flow generated by the glucose polymer icodextrin...
July 2018: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/29763967/machine-learning-algorithms-for-outcome-prediction-in-chemo-radiotherapy-an-empirical-comparison-of-classifiers
#15
Timo M Deist, Frank J W M Dankers, Gilmer Valdes, Robin Wijsman, I-Chow Hsu, Cary Oberije, Tim Lustberg, Johan van Soest, Frank Hoebers, Arthur Jochems, Issam El Naqa, Leonard Wee, Olivier Morin, David R Raleigh, Wouter Bots, Johannes H Kaanders, José Belderbos, Margriet Kwint, Timothy Solberg, René Monshouwer, Johan Bussink, Andre Dekker, Philippe Lambin
PURPOSE: Machine learning classification algorithms (classifiers) for prediction of treatment response are becoming more popular in radiotherapy literature. General Machine learning literature provides evidence in favor of some classifier families (random forest, support vector machine, gradient boosting) in terms of classification performance. The purpose of this study is to compare such classifiers specifically for (chemo)radiotherapy datasets and to estimate their average discriminative performance for radiation treatment outcome prediction...
July 2018: Medical Physics
https://www.readbyqxmd.com/read/29760130/clinical-radiological-and-microbiological-characteristics-of-mycobacterium-simiae-infection-in-97-patients
#16
Nathalie Coolen-Allou, Thomas Touron, Olivier Belmonte, Virgile Gazaille, Michel Andre, Jérôme Allyn, Sandrine Picot, Annabelle Payet, Nicolas Veziris
Mycobacterium simiae is a rare species of slow-growing nontuberculous mycobacteria (NTM). From 2002 to 2017, we conducted a retrospective study that included all patients with NTM-positive respiratory samples detected in two university hospitals of the French overseas department of Reunion Island. We recorded the prevalence of M. simiae in this cohort, as well as the clinical, radiological, and microbiological features of patients with at least 1 sample positive for M. simiae In our cohort, 97 patients (15...
July 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29756750/validation-of-the-pmd100tm-and-its-noltm-index-to-detect-nociception-at-different-infusion-regimen-of-remifentanil-in-patients-under-general-anaesthesia
#17
Pierre-André Stöckle, Marco Julien, Rami Issa, Elizabeth Décary, Véronique Brulotte, Pierre Drolet, Margaret Henri, Madeleine Poirier, Jean-François Latulippe, Marc Dorais, Olivier Verdonck, Louis-Philippe Fortier, Philippe Richebé
BACKGROUND: The NOL index is based on multiparametric analysis of heart rate (HR), skin conductance, wave plethysmography, and their time derivative. Our objective was to evaluate the NOL to detect standardized nociceptive stimuli with various remifentanil dosages under general anaesthesia. METHODS: A prospective, observational study at a single center (NCT02602379) included 40 ASA I to III patients undergoing laparotomy under remifentanil-desflurane anaesthesia with epidural analgesia...
May 14, 2018: Minerva Anestesiologica
https://www.readbyqxmd.com/read/29741930/highly-sensitive-index-of-cardiac-autonomic-control-based-on-time-varying-respiration-derived-from-ecg
#18
Pierre Gilfriche, Laurent M Arsac, Yannick Daviaux, Jaime Diaz-Pineda, Brice Miard, Olivier Morellec, Jean-Marc André
Frequency-domain indices of Heart Rate Variability (HRV) have been used as a marker of sympathovagal balance. However, they have been shown to be degraded by inter-individual or task-dependent variability, and especially breathing frequency. The study introduces a new method for analyzing respiratory (vagally) mediated Heart Rate Variability, to better assess subtle variations in sympathovagal balance, using ECG information. We evaluated the sensitivity of our new method comparatively to classic HRV analyses with cognitive workload...
May 9, 2018: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/29739839/transcriptional-induction-of-cell-wall-remodelling-genes-is-coupled-to-microtubule-driven-growth-isotropy-at-the-shoot-apex-in-arabidopsis
#19
Alessia Armezzani, Ursula Abad, Olivier Ali, Amélie Andres Robin, Laetitia Vachez, Antoine Larrieu, Ewa J Mellerowicz, Ludivine Taconnat, Virginie Battu, Thomas Stanislas, Mengying Liu, Teva Vernoux, Jan Traas, Massimiliano Sassi
The shoot apical meristem of higher plants continuously generates new tissues and organs through complex changes in growth rates and directions of its individual cells. Cell growth, which is driven by turgor pressure, largely depends on the cell walls, which allow cell expansion through synthesis and structural changes. A previous study revealed a major contribution of wall isotropy in organ emergence, through the disorganization of cortical microtubules. We show here that this disorganization is coupled with the transcriptional control of genes involved in wall remodelling...
June 4, 2018: Development
https://www.readbyqxmd.com/read/29729943/phenotype-penetrance-and-treatment-of-133-cytotoxic-t-lymphocyte-antigen-4-insufficient-subjects
#20
Charlotte Schwab, Annemarie Gabrysch, Peter Olbrich, Virginia Patiño, Klaus Warnatz, Daniel Wolff, Akihiro Hoshino, Masao Kobayashi, Kohsuke Imai, Masatoshi Takagi, Ingunn Dybedal, Jamanda A Haddock, David M Sansom, Jose M Lucena, Maximilian Seidl, Annette Schmitt-Graeff, Veronika Reiser, Florian Emmerich, Natalie Frede, Alla Bulashevska, Ulrich Salzer, Desirée Schubert, Seiichi Hayakawa, Satoshi Okada, Maria Kanariou, Zeynep Yesim Kucuk, Hugo Chapdelaine, Lenka Petruzelkova, Zdenek Sumnik, Anna Sediva, Mary Slatter, Peter D Arkwright, Andrew Cant, Hanns-Martin Lorenz, Thomas Giese, Vassilios Lougaris, Alessandro Plebani, Christina Price, Kathleen E Sullivan, Michel Moutschen, Jiri Litzman, Tomas Freiberger, Frank L van de Veerdonk, Mike Recher, Michael H Albert, Fabian Hauck, Suranjith Seneviratne, Jana Pachlopnik Schmid, Antonios Kolios, Gary Unglik, Christian Klemann, Carsten Speckmann, Stephan Ehl, Alan Leichtner, Richard Blumberg, Andre Franke, Scott Snapper, Sebastian Zeissig, Charlotte Cunningham-Rundles, Lisa Giulino-Roth, Olivier Elemento, Gregor Dückers, Tim Niehues, Eva Fronkova, Veronika Kanderová, Craig D Platt, Janet Chou, Talal A Chatila, Raif Geha, Elizabeth McDermott, Su Bunn, Monika Kurzai, Ansgar Schulz, Laia Alsina, Ferran Casals, Angela Deyà-Martinez, Sophie Hambleton, Hirokazu Kanegane, Kjetil Taskén, Olaf Neth, Bodo Grimbacher
BACKGROUND: Cytotoxic T-lymphocyte antigen 4 (CTLA-4) is a negative immune regulator. Heterozygous CTLA4 germline mutations can cause a complex immune dysregulation syndrome in human subjects. OBJECTIVE: We sought to characterize the penetrance, clinical features, and best treatment options in 133 CTLA4 mutation carriers. METHODS: Genetics, clinical features, laboratory values, and outcomes of treatment options were assessed in a worldwide cohort of CTLA4 mutation carriers...
May 4, 2018: Journal of Allergy and Clinical Immunology
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