keyword
https://read.qxmd.com/read/38271745/first-line-immunotherapy-for-lung-cancer-with-met-exon-14-skipping-and-the-relevance-of-tp53-mutations
#1
JOURNAL ARTICLE
Miriam Blasi, Jonas Kuon, Heike Lüders, Daniel Misch, Diego Kauffmann-Guerrero, Moritz Hilbrandt, Daniel Kazdal, Roger-Fei Falkenstern-Ge, Björn Hackanson, Sebastian Dintner, Martin Faehling, Martina Kirchner, Anna-Lena Volckmar, Hans-Georg Kopp, Michael Allgäuer, Christian Grohé, Amanda Tufman, Martin Reck, Nikolaj Frost, Albrecht Stenzinger, Michael Thomas, Petros Christopoulos
BACKGROUND: The efficacy of checkpoint inhibitors for non-small cell lung cancer (NSCLC) with MET exon 14 skipping (METΔ14ex) remains controversial. MATERIALS AND METHODS: 110 consecutive METΔ14ex NSCLC patients receiving first-line chemotherapy (CHT) and/or immunotherapy (IO) in 10 German centers between 2016-2022 were analyzed. RESULTS: Combined CHT-IO was given to 35/110 (32%) patients, IO alone to 43/110 (39%), and CHT to 32/110 (29%) upfront...
March 2024: European Journal of Cancer
https://read.qxmd.com/read/38117480/rapid-consumption-of-dihydrogen-injected-into-a-shallow-aquifer-by-ecophysiologically-different-microbes
#2
JOURNAL ARTICLE
Nina S Keller, Klas Lüders, Götz Hornbruch, Susann Birnstengel, Carsten Vogt, Markus Ebert, René Kallies, Andreas Dahmke, Hans H Richnow
The envisaged future dihydrogen (H2 ) economy requires a H2 gas grid as well as large deep underground stores. However, the consequences of an unintended spread of H2 through leaky pipes, wells, or subterranean gas migrations on groundwater resources and their ecosystems are poorly understood. Therefore, we emulated a short-term leakage incident by injecting gaseous H2 into a shallow aquifer at the TestUM test site and monitored the subsequent biogeochemical processes in the groundwater system. At elevated H2 concentrations, an increase in acetate concentrations and a decrease in microbial α-diversity with a concomitant change in microbial β-diversity were observed...
December 20, 2023: Environmental Science & Technology
https://read.qxmd.com/read/37897862/distinction-between-epileptic-and-non-epileptic-arousal-by-heart-rate-change
#3
JOURNAL ARTICLE
Takafumi Kubota, Suraj Thyagaraj, Huan Gia Huynh, Prasannakumar Kanubhai Gajera, Violet Awori, Jonathan L Zande, Hans O Lüders, Guadalupe Fernandez-Baca Vaca
OBJECTIVE: We investigated the difference in heart rate (HR) change between epileptic and non-epileptic arousals in adult patients with epilepsy (PWE). METHODS: This is a case-control study conducted at the University Hospitals of Cleveland Medical Center. Inclusion criteria are (1) adult (≥18 years old) PWE who had arousal related to a focal aware or impaired awareness automatism seizure with or without focal to bilateral tonic-clonic seizure during an Epilepsy Monitoring Unit (EMU) admission between January 2009 and January 2021 or (2) adult PWE who had a non-epileptic arousal during an EMU admission between July 2020 and January 2021...
October 26, 2023: Epilepsy & Behavior: E&B
https://read.qxmd.com/read/37283354/ictal-blinking-triggered-by-isolated-spikes-as-the-only-manifestation-of-seizures
#4
JOURNAL ARTICLE
Roohi Katyal, Shirin Jamal-Omidi, Takafumi Kubota, Naiara Garcia-Losarcos, Hans Luders
OBJECTIVE: To describe blinking as the only manifestation of seizures from isolated focal and generalized cortical spikes and investigate the relationship between blinks and epileptic discharges. METHODS: We measured the latency from the onset of spikes to the onset of blinks in two patients using electroencephalogram (EEG) and an electrooculogram (EOG), and calculated the median latency in both cases. We analyzed the latency from spike onset to the onset of additional specific eye movements, seen only in the second case...
April 2023: Epileptic Disorders: International Epilepsy Journal with Videotape
https://read.qxmd.com/read/37172444/bilateral-tonic-seizures-vs-bilateral-tonic-events-in-critically-ill-patients-differences-in-semiology
#5
JOURNAL ARTICLE
Roohi Katyal, Takafumi Kubota, Michael De Georgia, Hans O Lüders, Guadalupe Fernandez-Baca Vaca
PURPOSE: Our primary aim was to analyze bilateral epileptic tonic seizures (ETS) and bilateral non-epileptic tonic events (NTE) in critically ill patients. Our secondary aim was to analyze ETS per their epileptogenic zone. METHODS: We performed a retrospective analysis of clinical signs in patients with bilateral ETS and NTE. Two authors independently reviewed 34 videos of ETS in 34 patients and 15 videos of NTEs in 15 patients. Initial screening and review was performed in an unblinded manner...
July 2023: Seizure: the Journal of the British Epilepsy Association
https://read.qxmd.com/read/36966591/spectrum-of-motor-responses-elicited-by-electrical-stimulation-of-primary-motor-cortex-a-polygraphic-study-in-patients-with-epilepsy
#6
JOURNAL ARTICLE
Neel Fotedar, Guadalupe Fernandez-BacaVaca, Michael Rose, Jonathan P Miller, Hans O Lüders
OBJECTIVE: To study the neurophysiology of motor responses elicited by electrical stimulation of the primary motor cortex. METHODS: We studied motor responses in four patients undergoing invasive epilepsy monitoring and functional cortical mapping via electrical cortical stimulation using surface EMG electrodes. In addition, polygraphic analysis of intracranial EEG and EMG during bilateral tonic-clonic seizures, induced by cortical stimulation, was performed in two patients...
March 24, 2023: Epilepsy & Behavior: E&B
https://read.qxmd.com/read/35417829/a-descriptive-study-of-eye-and-head-movements-in-versive-seizures
#7
JOURNAL ARTICLE
Neel Fotedar, Prasannakumar Gajera, Nataliya Pyatka, Salam Nasralla, Takafumi Kubota, Guadalupe Fernandez-Baca Vaca, Aasef G Shaikh, Hans O Lüders
BACKGROUND: Versive seizures, consisting of forced, involuntary, sustained and unnatural turning of eyes and head toward one side, lateralize to the hemisphere contralateral to the direction of the eye and head turn. The characteristics of eye and head movements in version have been rarely and incompletely studied in spontaneous epileptic seizures as opposed to direct cortical stimulation studies. METHODS: We performed a single center retrospective analysis of a cohort of 28 patients with 43 seizures, who had been admitted to the adult epilepsy monitoring unit at University Hospitals Cleveland Medical Center between January 2009 and August 2020...
May 2022: Seizure: the Journal of the British Epilepsy Association
https://read.qxmd.com/read/34953285/epileptic-opsoclonus-due-to-cortical-dysplasia-of-the-left-posterior-temporal-cortex-a-simultaneous-electroencephalogram-and-electrooculogram-study
#8
JOURNAL ARTICLE
Jun Park, Guadalupe Fernandez Baca Vaca, Jonathan Miller, Hans Lüders
No abstract text is available yet for this article.
December 18, 2021: Seizure: the Journal of the British Epilepsy Association
https://read.qxmd.com/read/34519649/stereotactic-eeg-guided-radiofrequency-multiple-hippocampal-transection-seeg-guided-rf-mht-for-the-treatment-of-mesial-temporal-lobe-epilepsy-a-minimally-invasive-method-for-diagnosis-and-treatment
#9
JOURNAL ARTICLE
Naiara Garcia Losarcos, Jonathan Miller, Philip Fastenau, Shahram Amina, Christopher Bailey, Michael Deveraux, Guadalupe Fernandez-Baca Vaca, Lauren Ghanma Eyring, Nuria Lacuey, Jun Park, Michael Rose, Asim Shahid, Suraj Thyagaraj, Jonathan Zande, Hans Lüders
For the treatment of mesial temporal lobe epilepsy on the language-dominant side in patients at high risk of memory decline, we propose a minimally invasive diagnostic and treatment technique, adopting the principles of multiple hippocampal transections (MHT) using stereo-electroencephalography-guided radiofrequency (SEEG-guided-RF-MHT). This new technique allows targeting of the longitudinal fibers in the hippocampus critical for seizure spreading, while sparing the transverse circuits which are considered important for memory processing and avoiding discomfort and longer post-operatory recovery time associated with craniotomies...
October 1, 2021: Epileptic Disorders: International Epilepsy Journal with Videotape
https://read.qxmd.com/read/34049857/treatment-failure-in-giant-cell-arteritis
#10
RANDOMIZED CONTROLLED TRIAL
Sebastian H Unizony, Min Bao, Jian Han, Yves Luder, Andrey Pavlov, John H Stone
OBJECTIVE: Identify predictors of treatment failure in patients with giant cell arteritis (GCA) receiving tocilizumab in combination with glucocorticoids and in patients with GCA receiving only glucocorticoids. METHODS: Posthoc analysis of the Giant-Cell Arteritis Actemra trial including 250 patients who received tocilizumab every week plus a 26-week prednisone taper (n=100), tocilizumab every-other-week plus a 26-week prednisone taper (n=49) or placebo plus a 26-week (n=50) or 52-week (n=51) prednisone taper in the intention-to-treat population...
November 2021: Annals of the Rheumatic Diseases
https://read.qxmd.com/read/33794453/monitoring-of-the-effects-of-a-temporally-limited-heat-stress-on-microbial-communities-in-a-shallow-aquifer
#11
JOURNAL ARTICLE
Nina-Sophie Keller, Götz Hornbruch, Klas Lüders, Ulrike Werban, Carsten Vogt, René Kallies, Andreas Dahmke, Hans Hermann Richnow
Aquifer thermal energy storage (ATES) is a key concept for the use of renewable energy resources. Interest in ATES performed at high temperature (HT-ATES; > 60 °C) is increasing due to higher energetic efficiencies. HT-ATES induces temperature fluctuations that exceed the natural variability in shallow aquifers, which could lead to adverse effects in subsurface ecosystems by altering the groundwater chemistry, biodiversity, and microbial metabolic activity, resulting in changes of the groundwater quality, biogeochemical processes, and ecosystem functions...
August 10, 2021: Science of the Total Environment
https://read.qxmd.com/read/33784598/tocilizumab-vs-placebo-for-the-treatment-of-giant-cell-arteritis-with-polymyalgia-rheumatica-symptoms-cranial-symptoms-or-both-in-a-randomized-trial
#12
RANDOMIZED CONTROLLED TRIAL
Robert Spiera, Sebastian H Unizony, Min Bao, Yves Luder, Jian Han, Andrey Pavlov, John H Stone
OBJECTIVE: The randomized, placebo (PBO)-controlled GiACTA trial demonstrated the efficacy and safety of tocilizumab (TCZ) in patients with giant cell arteritis (GCA). The present study evaluated the efficacy of TCZ in patients with GCA presenting with polymyalgia rheumatica (PMR) symptoms only, cranial symptoms only or both PMR and cranial symptoms in the GiACTA trial. METHODS: In GiACTA, 250 patients with GCA received either TCZ weekly or every other week plus a 26-week prednisone taper or PBO plus a 26- or 52-week prednisone taper...
April 2021: Seminars in Arthritis and Rheumatism
https://read.qxmd.com/read/33260742/spinal-deformities-after-childhood-tumors
#13
JOURNAL ARTICLE
Anna K Hell, Ingrid Kühnle, Heiko M Lorenz, Lena Braunschweig, Katja A Lüders, Hans Christoph Bock, Christof M Kramm, Hans Christoph Ludwig, Konstantinos Tsaknakis
Childhood tumors of the central nervous system (CNS) and other entities affecting the spine are rare. Treatment options vary from surgical biopsy to partial, subtotal, and total resection, to radiation, to chemotherapy. The aim of this study is to investigate spinal deformity and subsequent surgical interventions in this patient cohort. A retrospective review at our institution identified children with CNS tumors, spinal tumors, and juxta-spinal tumors, as well as spinal deformities. Tumor entity, treatment, mobilization, and radiographic images were analyzed relative to the spinal deformity, using curve angles in two planes...
November 28, 2020: Cancers
https://read.qxmd.com/read/32198361/enigma-and-global-neuroscience-a-decade-of-large-scale-studies-of-the-brain-in-health-and-disease-across-more-than-40-countries
#14
REVIEW
Paul M Thompson, Neda Jahanshad, Christopher R K Ching, Lauren E Salminen, Sophia I Thomopoulos, Joanna Bright, Bernhard T Baune, Sara Bertolín, Janita Bralten, Willem B Bruin, Robin Bülow, Jian Chen, Yann Chye, Udo Dannlowski, Carolien G F de Kovel, Gary Donohoe, Lisa T Eyler, Stephen V Faraone, Pauline Favre, Courtney A Filippi, Thomas Frodl, Daniel Garijo, Yolanda Gil, Hans J Grabe, Katrina L Grasby, Tomas Hajek, Laura K M Han, Sean N Hatton, Kevin Hilbert, Tiffany C Ho, Laurena Holleran, Georg Homuth, Norbert Hosten, Josselin Houenou, Iliyan Ivanov, Tianye Jia, Sinead Kelly, Marieke Klein, Jun Soo Kwon, Max A Laansma, Jeanne Leerssen, Ulrike Lueken, Abraham Nunes, Joseph O' Neill, Nils Opel, Fabrizio Piras, Federica Piras, Merel C Postema, Elena Pozzi, Natalia Shatokhina, Carles Soriano-Mas, Gianfranco Spalletta, Daqiang Sun, Alexander Teumer, Amanda K Tilot, Leonardo Tozzi, Celia van der Merwe, Eus J W Van Someren, Guido A van Wingen, Henry Völzke, Esther Walton, Lei Wang, Anderson M Winkler, Katharina Wittfeld, Margaret J Wright, Je-Yeon Yun, Guohao Zhang, Yanli Zhang-James, Bhim M Adhikari, Ingrid Agartz, Moji Aghajani, André Aleman, Robert R Althoff, Andre Altmann, Ole A Andreassen, David A Baron, Brenda L Bartnik-Olson, Janna Marie Bas-Hoogendam, Arielle R Baskin-Sommers, Carrie E Bearden, Laura A Berner, Premika S W Boedhoe, Rachel M Brouwer, Jan K Buitelaar, Karen Caeyenberghs, Charlotte A M Cecil, Ronald A Cohen, James H Cole, Patricia J Conrod, Stephane A De Brito, Sonja M C de Zwarte, Emily L Dennis, Sylvane Desrivieres, Danai Dima, Stefan Ehrlich, Carrie Esopenko, Graeme Fairchild, Simon E Fisher, Jean-Paul Fouche, Clyde Francks, Sophia Frangou, Barbara Franke, Hugh P Garavan, David C Glahn, Nynke A Groenewold, Tiril P Gurholt, Boris A Gutman, Tim Hahn, Ian H Harding, Dennis Hernaus, Derrek P Hibar, Frank G Hillary, Martine Hoogman, Hilleke E Hulshoff Pol, Maria Jalbrzikowski, George A Karkashadze, Eduard T Klapwijk, Rebecca C Knickmeyer, Peter Kochunov, Inga K Koerte, Xiang-Zhen Kong, Sook-Lei Liew, Alexander P Lin, Mark W Logue, Eileen Luders, Fabio Macciardi, Scott Mackey, Andrew R Mayer, Carrie R McDonald, Agnes B McMahon, Sarah E Medland, Gemma Modinos, Rajendra A Morey, Sven C Mueller, Pratik Mukherjee, Leyla Namazova-Baranova, Talia M Nir, Alexander Olsen, Peristera Paschou, Daniel S Pine, Fabrizio Pizzagalli, Miguel E Rentería, Jonathan D Rohrer, Philipp G Sämann, Lianne Schmaal, Gunter Schumann, Mark S Shiroishi, Sanjay M Sisodiya, Dirk J A Smit, Ida E Sønderby, Dan J Stein, Jason L Stein, Masoud Tahmasian, David F Tate, Jessica A Turner, Odile A van den Heuvel, Nic J A van der Wee, Ysbrand D van der Werf, Theo G M van Erp, Neeltje E M van Haren, Daan van Rooij, Laura S van Velzen, Ilya M Veer, Dick J Veltman, Julio E Villalon-Reina, Henrik Walter, Christopher D Whelan, Elisabeth A Wilde, Mojtaba Zarei, Vladimir Zelman
This review summarizes the last decade of work by the ENIGMA (Enhancing NeuroImaging Genetics through Meta Analysis) Consortium, a global alliance of over 1400 scientists across 43 countries, studying the human brain in health and disease. Building on large-scale genetic studies that discovered the first robustly replicated genetic loci associated with brain metrics, ENIGMA has diversified into over 50 working groups (WGs), pooling worldwide data and expertise to answer fundamental questions in neuroscience, psychiatry, neurology, and genetics...
March 20, 2020: Translational Psychiatry
https://read.qxmd.com/read/32155575/could-the-2017-ilae-and-the-four-dimensional-epilepsy-classifications-be-merged-to-a-new-integrated-epilepsy-classification
#15
REVIEW
Felix Rosenow, Naoki Akamatsu, Thomas Bast, Sebastian Bauer, Christoph Baumgartner, Selim Benbadis, Adriana Bermeo-Ovalle, Stefan Beyenburg, Andrew Bleasel, Alireza Bozorgi, Milan Brázdil, Mar Carreño, Norman Delanty, Michael Devereaux, John Duncan, Guadalupe Fernandez-Baca Vaca, Stefano Francione, Naiara García Losarcos, Lauren Ghanma, Antonio Gil-Nagel, Hajo Hamer, Hans Holthausen, Shirin Jamal Omidi, Philippe Kahane, Giri Kalamangalam, Andrés Kanner, Susanne Knake, Stjepana Kovac, Karsten Krakow, Günter Krämer, Gerhard Kurlemann, Nuria Lacuey, Patrick Landazuri, Shi Hui Lim, Luisa V Londoño, Giorgio LoRusso, Hans Luders, Jayanti Mani, Riki Matsumoto, Jonathan Miller, Soheyl Noachtar, Rebecca O'Dwyer, André Palmini, Jun Park, Philipp S Reif, Jan Remi, Americo C Sakamoto, Bettina Schmitz, Susanne Schubert-Bast, Stephan Schuele, Asim Shahid, Bernhard Steinhoff, Adam Strzelczyk, C Akos Szabo, Nitin Tandon, Kiyohito Terada, Manuel Toledo, Walter van Emde Boas, Matthew Walker, Peter Widdess-Walsh
Over the last few decades the ILAE classifications for seizures and epilepsies (ILAE-EC) have been updated repeatedly to reflect the substantial progress that has been made in diagnosis and understanding of the etiology of epilepsies and seizures and to correct some of the shortcomings of the terminology used by the original taxonomy from the 1980s. However, these proposals have not been universally accepted or used in routine clinical practice. During the same period, a separate classification known as the "Four-dimensional epilepsy classification" (4D-EC) was developed which includes a seizure classification based exclusively on ictal symptomatology, which has been tested and adapted over the years...
May 2020: Seizure: the Journal of the British Epilepsy Association
https://read.qxmd.com/read/32073153/from-theory-to-practice-critical-points-in-the-2017-ilae-classification-of-epileptic-seizures-and-epilepsies
#16
COMMENT
André Palmini, Naoki Akamatsu, Thomas Bast, Sebastian Bauer, Christoph Baumgartner, Selim Benbadis, Adriana Bermeo-Ovalle, Stefan Beyenburg, Andrew Bleasel, Alireza Bozorgi, Milan Brázdil, Mar Carreño, Norman Delanty, Michael Devereaux, John S Duncan, Guadalupe Fernandez-Baca Vaca, Naiara García Losarcos, Lauren Ghanma, Antonio Gil-Nagel, Hajo Hamer, Hans Holthausen, Shirin J Omidi, Philippe Kahane, Giri Kalamangalam, Andrés Kanner, Susanne Knake, Stjepana Kovac, Guenter Kraemer, Gerhard Kurlemann, Nuria Lacuey, Patrick Landazuri, Shih Hui Lim, Giorgio LoRusso, Hans Luders, Jayanti Mani, Riki Matsumoto, Jonathan Miller, Soheyl Noachtar, Rebecca O'Dwyer, Jun Park, Philipp S Reif, Jan Rémi, Felix Rosenow, Americo Sakamoto, Susanne Schubert-Bast, Stephan Schuele, Asim Shahid, J Bernhard Steinhoff, Adam Strzelczyk, C Ákos Szabó, Nitin Tandon, Kiyohito Terada, Manuel Toledo, Walter van Emde Boas, Matthew Walker, Peter Widdess-Walsh
No abstract text is available yet for this article.
February 2020: Epilepsia
https://read.qxmd.com/read/31749151/biomarker-profile-for-prediction-of-response-to-smac-mimetic-monotherapy-in-pediatric-precursor-b-cell-acute-lymphoblastic-leukemia
#17
JOURNAL ARTICLE
Julia Zinngrebe, Ferdinand Schlichtig, Johann M Kraus, Malcolm Meyer, Elena Boldrin, Hans A Kestler, Lüder-Hinrich Meyer, Pamela Fischer-Posovszky, Klaus-Michael Debatin
SMAC mimetics (SMs) targeting inhibitor of apoptosis proteins (IAPs) activate cell death pathways, and are currently being evaluated in clinical trials. Their successful therapeutic implementation requires upfront identification of patients who could benefit from a SM-based treatment but biomarkers for SM sensitivity have not yet been described. Here, we analyzed the intrinsic activity of two monovalent (AT406 and LCL161) and two bivalent (Birinapant and BV6) SMs on unselected patient-derived pediatric precursor B-cell acute lymphoblastic leukemia (BCP-ALL) identifying a subset of patient samples to be particularly sensitive to SM-induced cell death...
November 20, 2019: International Journal of Cancer. Journal International du Cancer
https://read.qxmd.com/read/31358732/prediction-of-venetoclax-activity-in-precursor-b-all-by-functional-assessment-of-apoptosis-signaling
#18
JOURNAL ARTICLE
Felix Seyfried, Salih Demir, Rebecca Louise Hörl, Felix Uli Stirnweiß, Jeremy Ryan, Annika Scheffold, Mariana Villalobos-Ortiz, Elena Boldrin, Julia Zinngrebe, Stefanie Enzenmüller, Silvia Jenni, Yi-Chien Tsai, Beat Bornhauser, Axel Fürstberger, Johann Michael Kraus, Hans Armin Kestler, Jean-Pierre Bourquin, Stephan Stilgenbauer, Anthony Letai, Klaus-Michael Debatin, Lüder Hinrich Meyer
Deregulated cell death pathways contribute to leukemogenesis and treatment failure in B-cell precursor acute lymphoblastic leukemia (BCP-ALL). Intrinsic apoptosis signaling is regulated by different proapoptotic and antiapoptotic molecules: proapoptotic BCL-2 homology domain 3 (BH3) proteins activate prodeath molecules leading to cellular death, while antiapoptotic molecules including B-cell lymphoma 2 (BCL-2) prevent activation of prodeath proteins and counter-regulate apoptosis induction. Inhibition of these antiapoptotic regulators has become a promising strategy for anticancer treatment, but variable anticancer activities in different malignancies indicate the need for upfront identification of responsive patients...
July 29, 2019: Cell Death & Disease
https://read.qxmd.com/read/31237526/waveform-window-45-cortical-amplitude-reduction-of-somatosensory-evoked-potentials-during-epileptic-seizure
#19
JOURNAL ARTICLE
Christopher Diaczun, Hans O Lüders
No abstract text is available yet for this article.
June 25, 2019: Neurodiagnostic Journal
https://read.qxmd.com/read/30924146/critique-of-the-2017-epileptic-seizure-and-epilepsy-classifications
#20
JOURNAL ARTICLE
Hans Lüders, Naoki Akamatsu, Shahram Amina, Christoph Baumgartner, Selim Benbadis, Adriana Bermeo-Ovalle, Andrew Bleasel, Alireza Bozorgi, Mar Carreño, Michael Devereaux, Guadalupe Fernandez-Baca Vaca, Stefano Francione, Naiara García Losarcos, Hajo Hamer, Hans Holthausen, Shirin Jamal Omidi, Giridhar Kalamangalam, Andrés Kanner, Susanne Knake, Nuria Lacuey, Samden Lhatoo, Shih-Hui Lim, Jayanthi Mani, Riki Matsumoto, Jonathan Miller, Soheyl Noachtar, André Palmini, Jun Park, Felix Rosenow, Asim Shahid, Stephan Schuele, Bernhard Steinhoff, Charles Ákos Szabo, Nitin Tandon, Kiyohito Terada, Walter Van Emde Boas, Peter Widdess-Walsh, Philippe Kahane
This article critiques the International League Against Epilepsy (ILAE) 2015-2017 classifications of epilepsy, epileptic seizures, and status epilepticus. It points out the following shortcomings of the ILAE classifications: (1) they mix semiological terms with epileptogenic zone terminology; (2) simple and widely accepted terminology has been replaced by complex terminology containing less information; (3) seizure evolution cannot be described in any detail; (4) in the four-level epilepsy classification, level two (epilepsy category) overlaps almost 100% with diagnostic level one (seizure type); and (5) the design of different classifications with distinct frameworks for newborns, adults, and patients in status epilepticus is confusing...
June 2019: Epilepsia
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